Oncology -Optical Coherence Tomography News

Articles in category: Oncology

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1. The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe?
  
  Explore MDPI Open Access Journals Platform May 21 2020 Dermatology , Oncology , Ophthalmology
  
  Purpose: To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma. Methods: Records of 615 patients treated for choroidal melanoma between January 2017 and December 2019 were reviewed. Patients were excluded if iris and/or ciliary body involvement (106 patients), inadequate fundus photography (26 patients), no images available for review (21 patients) and/or treatment was not primary (11 patients). Demographic data and AJCC TNM Stage were collected. Color fundus and autofluorescence photographs (FAF), optical coherence tomography (OCT) and B-scan ultrasounds were prospectively reviewed. MOLES scores were assigned according to five criteria ...
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2. Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery
  
  Explore Optical Coherence Tomography News Apr 26 2020 Oncology
  
  Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...
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  Mentions: University of Western Australia Andrea Curatolo Brendan F. Kennedy
3. University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk
  
  Explore Optical Coherence Tomography News Apr 21 2020 Gastroenterology , Oncology
  
  University of Pittsburg Receives a 2020 NIH Grant for $437,317 for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk. The principal investigator is Yang Liu. Below is a summary of the proposed work. The effectiveness of colorectal cancer (CRC) screening, with a concomitant increased emphasis on detection of even the smallest adenomas, has resulted in a new clinical challenge. An increased number of people are being identified as harboring an adenomatous polyp, the benign precursor to CRC. These patients are recommended to undergo surveillance, or repeated colonoscopy for monitoring for recurrence ...
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  Mentions: University of Pittsburgh National Institutes of Health
4. Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery
  
  Explore Cancer Research Apr 16 2020 Oncology
  
  Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...
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  Mentions: University of Western Australia Brendan F. Kennedy Kelsey M. Kennedy
5. High-resolution Imaging Coupled With Elastography May Accurately Detect Breast Cancer in Surgical Margins
  
  Explore aacr.org Apr 16 2020 Oncology
  
  A high-resolution, three-dimensional imaging technique, when combined with quantitative measurement of tissue elasticity, could accurately detect cancer within the resected margins of surgical specimens taken from patients undergoing breast-conserving surgery, according to a study published in Cancer Research , a journal of the American Association for Cancer Research. “Despite living in the ‘digital age,’ surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery,” said Brendan F. Kennedy, PhD , associate professor in the School of Engineering at The University of Western Australia (UWA) and laboratory head of BRITElab ...
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  Mentions: University of Western Australia Brendan F. Kennedy Kelsey M. Kennedy
6. High-res imaging with elastography may accurately detect breast cancer in surgical margins
  
  Explore EurekAlert! Apr 15 2020 Oncology
  
  Bottom Line: A high-resolution, three-dimensional imaging technique, when combined with quantitative measurement of tissue elasticity, could accurately detect cancer within the resected margins of surgical specimens taken from patients undergoing breast-conserving surgery. Journal in Which the Study was Published: Cancer Research , a journal of the American Association for Cancer Research Authors: Brendan F. Kennedy, PhD, associate professor in the School of Engineering at The University of Western Australia (UWA) and laboratory head of BRITElab at the Harry Perkins Institute of Medical Research in Perth, Western Australia; and Christobel Saunders, MBBS, professor in the School of Medicine at UWA Background: "Despite ...
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  Mentions: University of Western Australia Brendan F. Kennedy OncoRes Medical
7. Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue micro‐architecture contrast
  
  Explore Wiley Online Library Mar 12 2020 Oncology
  
  Effective intraoperative tumor margin assessment is needed to reduce re‐excision rates in breast‐conserving surgery (BCS). Mapping the attenuation coefficient in optical coherence tomography (OCT) throughout a sample to create an image (attenuation imaging) is one promising approach. For the first time, three‐dimensional OCT attenuation imaging of human breast tissue micro‐architecture using a wide‐field (up to ~45 × 45 × 3.5 mm) imaging system is demonstrated. Representative results from three mastectomy and one BCS specimen (from 31 specimens) are presented with co‐registered postoperative histology. Attenuation imaging is shown to provide substantially improved contrast over OCT, delineating ...
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  Mentions: University of Western Australia Brendan F. Kennedy
8. Beating Cancer - One Patient at a Time
  
  Explore Newswise Feb 20 2020 Gastroenterology , Oncology
  
  Like most people, John Gifford wasn't looking forward to a colonoscopy when he arrived on the UCI Medical Center campus in Orange in 2018. The Riverside man, 65, was concerned about his family history of colorectal cancer and had dutifully scheduled an appointment with UCI Health gastroenterologist Dr. William Karnes. The exam turned out to be intriguing and enlightening - a far cry from what one expects during a colonoscopy, Gifford recalls with a laugh.
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  Mentions: National Institutes of Health California Institute of Technology UC Irvine
9. Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study
  
  Explore ScienceDirect Dec 8 2019 Dermatology , Oncology
  
  Background The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy of optical coherence tomography in assessing cutaneous cancer margins of the face. Materials and Methods The excised tissue specimens that were examined, in this study, were acquired from 70 patients with 70 facial cancer lesions, with no nodal disease. Forty lesions were basal cell carcinomas (150 margins; 27 tumour positive) and ...
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  Mentions: University College London Colin Hopper
10. Machine learning, imaging technique may boost colon cancer diagnosis
  
  Explore The Source Dec 5 2019 Gastroenterology , Oncology
  
  Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal. Current colon cancer screening is performed by flexible colonoscopy. The procedure involves visual inspection of the mucosal lining of the colon and rectum with a camera mounted on an endoscope. Abnormal appearing areas are then biopsied for analysis. Although this is the current standard of ...
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  Mentions: Washington University in St. Louis Quing Zhu Chao Zhou
11. Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography
  
  Explore Wiley Online Library Oct 19 2019 Oncology
  
  Background Currently, positive margins at lumpectomy contribute to health care cost, patient anxiety, and treatment delay. Multiple technology solutions are being explored with the aim of lowering re‐excision rates for breast‐conserving surgery (BCS). We examined wide‐field optical coherence tomography (WF‐OCT), an innovative adjunct intraoperative imaging tool for tissue visualization of margins. Methods This IRB‐approved pilot study included women with invasive or in situ carcinoma scheduled for primary BCS. Lumpectomy specimens and any final/revised margins were imaged by optical coherence tomography immediately prior to standard histological processing. The optical coherence tomography used provided two‐dimensional ...
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12. Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)
  
  Explore Home - ClinicalTrials.gov Sep 24 2019 Oncology , Clinical Trials
  
  The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques. The IHU-SPECTRA research unit, entirely dedicated to the development of fluorescence-guided surgery, was set up to test several innovations as part of a large-scale project (ELIOS: Endoscopic Luminescent Imaging for Precision Oncology Surgery), funded by the ARC Foundation for Cancer Research. The proposed research protocol is part of the ELIOS project and targets in particular colon tumours. The Holy Grail in oncology surgery is the radical removal of cancer cells in order to reduce the rate of tumour recurrences and increase ...
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  Mentions: LLTech LLTech Light-CT Scanner
13. Analysis of low-scattering regions in optical coherence tomography
  
  Explore OSA | OSA Publishing Jul 26 2019 Neurology , Oncology
  
  Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering biological structures of interest. In a human tumor xenograft murine model, we show that these correspond to lymphatic vessels and nerves; extensive histopathologic validation studies are reported to unequivocally establish ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma B. Hyle Park
14. Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method
  
  Explore ScienceDirect Jul 21 2019 Oncology
  
  Background The purpose of this study was to develop a deep learning classification approach to distinguish cancerous from noncancerous regions within optical coherence tomography (OCT) images of breast tissue for potential use in an intraoperative setting for margin assessment. Methods A custom ultrahigh-resolution OCT (UHR-OCT) system with an axial resolution of 2.7 μm and a lateral resolution of 5.5 μm was used in this study. The algorithm used an A-scan-based classification scheme and the convolutional neural network (CNN) was implemented using an 11-layer architecture consisting of serial 3 × 3 convolution kernels. Four tissue types were classified, including adipose ...
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  Mentions: Columbia University UC Irvine Christine P. Hendon
15. Corneal graphite deposit on anterior segment optical coherence tomography
  
  Explore Indian Journal of Ophthalmology (IJO) Jun 1 2019 Oncology
  
  Retained intraocular graphite foreign bodies are uncommon and generally remain inert in the eye. A 16-year-old girl complained of a black spot on her right eye since 3 months following pencil tip trauma. Examination revealed a subconjunctival greyish-black nodular mass with a metallic sheen on the 5 O' clock limbus with involvement of the adjacent corneal stroma and endothelium [Figure 1] a. Optical coherence tomography revealed subconjunctival [ [Figure 1] b arrow], corneal stromal, and endothelial [ [Figure 1] b arrowhead] hyporeflective material with intense backshadowing. This visual impression will help differentiate pigmented conjunctivo--corneal lesion from other reported mimickers such as melanoma ...
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  Mentions: L V Prasad Eye Institute
16. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size
  
  Explore arxiv.org Apr 14 2019 Oncology
  
  $Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size$
  Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the cell line HCT116. The spheroid RIs are compared to study the effect of growth time. To improve confocal microscopy imaging protocols, two immersion media (glycerol and ScaleView-A2) matching the spheroid ...
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  Mentions: University of Auckland Frederique Vanholsbeeck
17. Toward an All-Optical Biopsy
  
  Explore osa-opn.org Mar 30 2019 Oncology
  
  Combining multiple photonic imaging techniques could allow for new, noninvasive approaches to tumor detection and assessment, meeting clinical challenges at a time of rising global cancer incidence. [Getty Images] A compact experimental setup for multimodal nonlinear microscopy in clinical settings. [Leibniz-IPHT, S. Döring] Aging populations, exposure to environmental contamination in developing countries, and other factors are driving significant increases in cancer worldwide. The World Health Organization estimates that globally, the number of cancer cases will reach 21.6 million by 2030, nearly double the 14 million patients in 2012. In Germany alone, malignant tumors are responsible for a quarter ...
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18. Melanoma Blood Vessel Changes Detected with OCT Imaging
  
  Explore Photonics.com Mar 25 2019 Dermatology , Oncology
  
  An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...
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19. Optical probe at surgeon's fingertips for breast cancer removal
  
  Explore electronics360.globalspec.com Mar 14 2019 Oncology , Probes
  
  A finger-mounted probe is under development at the University of Western Australia to improve the surgical removal of breast cancer. This approach could be of value in scenarios where the use of a relatively bulky handheld probe is not convenient, such as when assessing if residual tumor is present in small cavities following excision of the main tumor mass in breast-conserving surgery. The device might also prove useful for brain and liver surgery and other types of cancer. A fiber probe incorporated into a wearable thimble uses quantitative micro-elastography (QME) to translate the The finger-mounted probe is placed perpendicular to ...
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  Mentions: University of Western Australia
20. Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium
  
  Explore Indian Journal of Ophthalmology (IJO) Mar 1 2019 Oncology , Ophthalmology
  
  Congenital hypertrophy of retinal pigment epithelium (CHRPE) is a benign, pigmented, flat lesion arising from the retinal pigment epithelium (RPE). In this study, we describe optical coherence tomography angiography (OCTA) features of two eyes with solitary CHRPE. We found that the retinal vasculature over CHRPE was normal in both cases. We observed that in solitary CHRPE, segmentation artifacts can interfere in the interpretation of retinal vasculature due to thinning of the outer retina. Visualization of the underlying choroidal vasculature was obscured to some extent by masking effect of the hyperpigmented RPE. The choroidal vasculature was better appreciated on en face ...
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21. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography
  
  Explore Nature Publishing Group Feb 19 2019 Neurology , Oncology
  
  Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...
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  Mentions: Institute of Applied Physics Grigory V. Gelikonov Elena V. Zagaynova
22. Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma
  
  Explore Cancer Research Feb 18 2019 Oncology , Ophthalmology
  
  The current gold standard for the clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients which can add an additional burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT), with its high-resolution and intermediate penetration depth, can potentially provide required diagnostic information noninvasively. Here we present an image analysis algorithm, 'optical properties extraction (OPE)', that improves the specificity and sensitivity of OCT by identifying unique ...
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  Mentions: Peter E. Andersen Technical University of Denmark (DTU)
23. Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts
  
  Explore uspto.gov Jan 22 2019 Gastroenterology , Oncology , Pulmonology , Patents , Probes
  
  A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...
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  Mentions: Zhongping Chen UC Irvine Qifa Zhou
24. Volumetric analysis of breast cancer tissues using machine learning and swept-source optical coherence tomography
  
  Explore OSA | OSA Publishing Jan 3 2019 Oncology
  
  In breast cancer, 20%–30% of cases require a second surgery because of incomplete excision of malignant tissues. Therefore, to avoid the risk of recurrence, accurate detection of the cancer margin by the clinician or surgeons needs some assistance. In this paper, an automated volumetric analysis of normal and breast cancer tissue is done by a machine learning algorithm to separate them into two classes. The proposed method is based on a support-vector-machine-based classifier by dissociating 10 features extracted from the A-line, texture, and phase map by the swept-source optical coherence tomographic intensity and phase images. A set of 88 ...
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  Mentions: Dalip Singh Mehta Indian Institute of Technology at Delhi UCLA
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