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Michelson Diagnostics , the UK-based medical device company focused on multi-beam Optical Coherence Tomography technology, has closed the £2.5m first tranche of its “Series B” financing, led by strategic investor and medical specialist Smith & Nephew alongside new investor Kent County Council as well as existing investors. The £2.5m investment will be used to expand Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-center clinical biopsy avoidance study; and explore further applications in wound care and dentistry. VivoSight is a point-of-care tissue-imaging system that for the first time ...
We evaluate if the relationship between optical coherence tomography (OCT) of the retinal nerve fibre layer (RNFL) continued over long-term visual recovery in 107 patients undergoing pituitary decompression. Recently, it has been recognized that OCT of RNFL has prognostic value in predicting visual outcomes after surgery for chiasmal compression caused by pituitary tumours. Patients were followed up at three time points: pre-operative (visit 1), 6 –10 weeks post-operative (visit 2) and 9–15 months follow-up (visit 3). We found that patients with thin pre-operative RNFL had more severe visual field defects (mean deviation [MD] -9.22 versus -3.96 decibels ...
Gastrointestinal cancers are very difficult to diagnosis due to poor biopsy and diagnosis techniques. The invention is a device that is minimally invasive and improves biopsy technique by enabling the physician to visualize a tissue in real time prior to its biopsy. This allows for improved biopsy collection and thereby increases the diagnosis accuracy. FULL DESCRIPTION Gastrointestinal (GI) cancers cause 140,000 deaths and more than 290,000 new cases in the US in 2014. These include esophageal, colorectal cancer and many others. The current standard for early diagnosis of GI cancers is to perform histological analysis based on biopsy ...
Prostate cancer (PCa) is the most common non-cutaneous malignancy in men. Men suspected with PCa are then offered transrectal ultrasound (TRUS) guided prostate biopsies to confirm the diagnosis, which falls short of making a reliable differentiation between cancer and benign hyperplasia of the gland. Suspected cancerous lesions tend to be stiffer (or harder to feel) than benign tissue. Various elastography modalities such as Ultrasound elastography and MRI elastography are known to have poor spatial resolution, which limits their ability to differentiate small lesions and in identifying early and subtle changes. OCT is an optical imaging technique that enables high-resolution, cross-sectional ...
We report the case of a three-year-old child referred to the Neuro-ophthalmology Department with the diagnosis of benign intracranial tumor in close relation to the left optic nerve and to the optic chiasm. Visual acuity, intrinsic and extrinsic ocular motility and fundoscopy were normal and without asymmetries. Given the age of the child and the impossibility of performing perimetry, we decided to perform visual evoked potentials and Optical Coherence Tomography (OCT) of the optic nerve, with measurement of the peripapillary retinal nerve fiber layer. The result was considered normal and symmetrical. The tomographic study the optic nerve, combined with visual ...
University of North Carolina at Chapel Hill Received at 2015 NIH Grant for $142,199 for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment. The principal investigator is Amy Oldenburg. The program began in 2014 and ends in 2015. Below is as summary of the proposed work. With no available targeted therapies, basal-like breast cancers are particularly aggressive cancers with a poor prognosis. Basal-like breast cancers have unique stromal-epithelial interactions within their microenvironments. The availability of quantitative 3D tissue culture assays to measure the response of basal-like cell line models in their microenvironments may lead to new ...
We will use optical coherence tomography to detect the ex-vivo tissue image of surgical removed melanoma or other benign pigmented lesions of skin.
The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six ...
We report our preliminary results on quantification of glucose and dimethyl sulfoxide (DMSO) diffusion in normal and cancerous human bladder tissues in vitro by using a spectral domain optical coherence tomography (SD-OCT). The permeability coefficients (PCs) of a 30% aqueous solution of glucose are found to be (7.92 ± 0.81) × 10 -6 cm s -1 and (1.19 ± 0.13) × 10 -5 cm s -1 in normal and cancerous bladder tissues, respectively. The PCs of 50% DMSO are calculated to be (8.99 ± 0.93) × 10 -6 cm s -1 and (1.43 ± 0.17) × 10 -5 cm s ...
A 62-year-old man presented with a 9-month history of a bleeding lesion. Clinical evaluation showed a 5-mm red-to-black keratotic papule on the first digit of the left foot (Fig 1, A).
Background and Objective We utilize a miniature, dual-modality endoscope that combines fluorescence-based surface magnifying chromoendoscopy (SMC) and optical coherence tomography (OCT) to follow the anatomical changes that occur during adenoma development in the mouse colon. Materials and Methods Twenty-five mice were treated with the carcinogen azoxymethane (AOM) to induce tumor development in the distal colon, or were treated with saline as control, and were imaged over six months. OCT detects adenoma number with high sensitivity and specificity and can measure lesion size. In methylene blue-lavaged colons, SMC detects changes in the colonic crypts. SMC images of control mouse colons exhibit ...
This intraoperative study is a prospective study analyzing specimens from fifty subjects. Patients scheduled to undergo breast- conserving surgery will be recruited in accordance with the inclusion and exclusion criteria. The study period per subject is the time it takes to assess the ex vivo breast tissue sample using the study device. Image review will be conducted during surgery and compared to the margin status findings in the post-operative pathology report.
We present first quantitative three-dimensional (3D) data sets recorded using optical coherence elastography (OCE) for the diagnosis and detection of prostate cancer (PCa). 120 transrectal ultrasound guided prostate biopsy specimens from 10 men suspected with prostate cancer were imaged using OCE. 3D quantitative mechanical assessment of biopsy specimens obtained in kilopascals (kPa) at an interval of 40 µm was compared with histopathology. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE in comparison to histopathology. The results show OCE imaging could reliably differentiate between benign prostate tissue, acinar atypical hyperplasia, prostatic intraepithelial neoplasia and malignant PCa. The ...
Since it was first used to evaluate human genitourinary tissue in 1997, OCT has emerged as a promising modality to provide real-time, high-resolution imaging of urologic organs. In the bladder, it has demonstrated a high sensitivity in identifying regions of the bladder suspicious for CIS and between invasive and noninvasive malignancy; it has been studied as an “optical biopsy” both during the initial cystoscopic diagnosis and intraoperatively in bladder-preserving surgery. Several small, ex vivo studies have shown promising results in the ability of OCT to demonstrate histopathologic alterations to renal morphology such as in renal ischemia and malignancy. It may ...
The current diagnostic standard for grading and staging of non-muscle-invasive bladder cancer (NMIBC) is based on the histopathology obtained during transurethral resection of the bladder tumour (TURBT) or biopsies. Although considered reference standard, this technique has some limitations: First, no real-time intraoperative histological information is obtained on stage and grade. Real-time intraoperative histological information could be helpful when NMIBC is treated by electric coagulation or laser ablation. The urologist has to rely on his/her judgement of stage and grade since no tissue is harvested for histological confirmation. In addition, in many centres, patients with a history of low-grade, non-invasive ...
Background: Vulvar squamous cell carcinoma (VSCC) is treated with wide local excision. The challenge is to remove as much skin as necessary to prevent recurrence, but meanwhile preserve genital skin to diminish morbidity. Optical coherence tomography (OCT) is a noninvasive imaging tool that produces cross-sectional images. Optical coherence tomography could be helpful in determining appropriate surgical margins during excision of VSCC. Objective: This study aimed to assess the value of OCT in determining appropriate surgical margins in patients operated for VSCC. We hypothesize that benign tissue will differ qualitatively (presence of clear epidermal layers) and quantitatively (epidermal layer thickness and ...
B arrett’s esophagus (BE) is the precursor lesion to esophageal adenocarcinoma, which in an invasive stage causes significant morbidity and mortality. Surgery was the mainstay of treatment for patients with high-grade dysplasia (HGD) and adenocarcinoma associated with BE. However, surgery in itself carries substantial morbidity. There has been tremendous progress in the minimally invasive treatment of BE in the past decade. The premise to be aggressive in treating dysplastic BE and early-stage adenocarcinoma is to prevent progression to an advanced-stage cancer. Most interventional endoscopists are comfortable treating dysplasia and intramucosal esophageal cancer, although recently there have been emerging data ...
Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility ...
We report an automated classifier to detect the presence of basal cell carcinoma in images of mouse skin tissue samples acquired by polarization-sensitive optical coherence tomography (PS-OCT). The sensitivity and specificity of the classifier based on combined information of the scattering intensity and birefringence properties of the samples are significantly higher than when intensity or birefringence information are used alone. The combined information offers a sensitivity of 94.4% and specificity of 92.5%, compared to 78.2% and 82.2% for intensity-only information and 85.5% and 87.9% for birefringence-only information. These results demonstrate that analysis of the ...
Perimeter Medical Imaging Inc., a developer of real time imaging systems for in-surgery tumour margin assessment, today announced an expanded relationship with University Health Network (UHN), the largest hospital-based research program in Canada, which includes closer research ties and a unique risk-sharing partnership. Perimeter has worked closely with the Princess Margaret Cancer Centre, a UHN hospital and recognized global leader in cancer research, to test the clinical capabilities of Perimeter’s ‘OTIS’ tumour margin assessment solution. Promising clinical results from the first trial have led to this expansion of the relationship which includes both additional clinical activities and a risk-sharing ...
Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility ...
Optical coherence tomography (OCT) has become essential to the practice of ophthalmology, offering superior resolution of the retina and some of the adjacent tissues for diagnosis and treatment of eye diseases. New OCT modalities have now been assimilated into ophthalmic oncology to help track the status of ocular and periocular tumors through retinal symptoms. “ Optical coherence tomography imaging of ocular and periocular tumours ,” a review of newer OCT modalities including anterior segment (AS), ultra-high resolution (UHR), spectral domain (SD) and enhanced depth imaging (EDI), describes the current advantages and limitations of their use. Use of OCT shows mixed results The ...
2014 R&D 100 Winner There are two forms of esophageal cancer: squamous cell carcinoma and adenocarcinoma. Adenocarcinoma is increasing at a rate greater than all other cancers in the U.S. In fact, the American Cancer Society estimated that in 2013, nearly 18,000 new cases of esophageal cancer cases will be diagnosed and more than 15,000 people will die from the condition. Currently, imaging and screening practices of esophageal tissue are time consuming and costly with questionable effectiveness. For the patient, this process is also invasive. However, NinePoint Medical and Farm Design have developed a solution, the ...
