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OCT Products in the News
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(11 articles) University of Illinois at Urbana-Champaign
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People in the News
(10 articles) Stephen A. Boppart
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Nanoshells for Photothermal Cancer Therapy
Explore Article SpringerLink Home (Mar 11 2010) Oncology
Cancer is a leading cause of death in the United States and contributes to yearly rising health care costs. Current methods of treating cancer involve surgical removal of easily accessible tumors, radiation therapy, and chemotherapy. These methods do not always result in full treatment of the cancer and can in many cases damage healthy cells both surrounding the tissue area and systemically. Nanoshells are optically tunable core/shell nanoparticles that can be fabricated to strongly absorb in the near-infrared (NIR) region where light transmits deeply into tissue. When injected systemically, these particles have been shown to accumulate in the tumor due ...
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Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy
Explore Article SpringerLink Home (Mar 11 2010) Oncology
Gold nanorods (GNRs) are strongly absorbing at near-infrared (NIR) frequencies and can be employed as multifunctional agents for biological imaging and theragnostics. GNRs can support nonlinear optical microscopies based on two-photon-excited luminescence and can enhance the contrast of biomedical imaging modalities such as optical coherence tomography and photoacoustic tomography. GNRs are also efficient at mediating the conversion of NIR light energy into heat and can generate localized photothermal effects. However, future clinical applications will require the rigorous removal of CTAB, a micellar surfactant used in GNR synthesis, and reliable methods of surface functionalization for cell-selective targeting and for minimizing nonspecific ...
Comment on Article Mentions: Purdue University Alexander Wei
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Potential of optical coherence tomography for early diagnosis of oral malignancies
Explore Article Expert Reviews (Mar 11 2010) Oncology
With nearly 1,500,000 new patients diagnosed every year in the USA, cancer poses a considerable challenge to healthcare today. Oral cancer is responsible for a sizeable portion of deaths due to cancer, primarily because it is diagnosed at a late stage when the prognosis is poor. Current methods for diagnosing oral cancer need to be augmented by better early detection, monitoring and screening modalities. A new approach is needed that provides real-time, accurate, noninvasive diagnosis. The results of early clinical trials using in vivo optical coherence tomography for the diagnosis of oral dysplasia and malignancy are encouraging.Comment on Article Mentions: UC Irvine Petra Wilder-Smith
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Longitudinal optical imaging of tumor metabolism and hemodynamics
Explore Article SPIE Digital Library (Mar 10 2010) Oncology
An important feature of tumor hypoxia is its temporal instability, or “cycling hypoxia.” The primary consequence of cycling hypoxia is increased tumor aggressiveness and treatment resistance beyond that of chronic hypoxia. Longitudinal imaging of tumor metabolic demand, hemoglobin oxygen saturation, and blood flow would provide valuable insight into the mechanisms and distribution of cycling hypoxia in tumors. Fluorescence imaging of metabolic demand via the optical redox ratio (fluorescence intensity of FAD/NADH), absorption microscopy of hemoglobin oxygen saturation, and Doppler optical coherence tomography of vessel morphology and blood flow are combined to noninvasively monitor changes in oxygen supply and demand in ...
Comment on Article Mentions: Joseph A. Izatt Duke University Melissa C. Skala
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Application of intravital microscopy in studies of tumor microcirculation
Explore Article SPIE Digital Library (Mar 10 2010) Oncology
To grow and progress, solid tumors develop a vascular network through co-option and angiogenesis that is characterized by multiple structural and functional abnormalities, which negatively influence therapeutic outcome through direct and indirect mechanisms. As such, the morphology and function of tumor blood vessels, plus their response to different treatments, are a vital and active area of biological research. Intravital microscopy (IVM) has played a key role in studies of tumor angiogenesis, and ongoing developments in molecular probes, imaging techniques, and postimage analysis methods have ensured its continued and widespread use. In this review we discuss some of the primary advantages ...
Comment on Article Mentions: University of Sheffield Steven J. Matcher
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Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography
Explore Article www3.interscience.wiley.com (Mar 7 2010) Oncology
Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP/NB, and 60% G/SP/BC ...
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Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT)
Explore Article SPIE Digital Library (Mar 2 2010) Oncology , Otolaryngology
Optical coherence tomography (OCT) is a promising method in the early diagnosis of oral cavity cancer. The objective of the present study is to determine normal values of epithelial thickness in the oral cavity, as no such data are to be found in the literature. In healthy test persons, epithelial thickness of the oral mucosa was determined with the help of OCT separately for each side at nine different locations. Special attention was directed to those sites having the highest incidence for the development of dysplasias and carcinomas. Depending on the location within the oral cavity, the epithelium demonstrated a ...
Comment on Article Mentions: Ludwig Maximilians Universität München
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Michelson Diagnostics Reports First Quantitative Results on Cancer Diagnosis Using Multi-beam OCT imaging
Explore Article Optical Coherence Tomography News (Mar 2 2010) Oncology , Other Business News
(Orpington, UK) March 2, 2010 -- The first quantitative results from a study on the use of multi-beam OCT imaging for oral cancer diagnosis have been announced at the 2nd Scientific Meeting of the Head and Neck Optical Diagnostics Society (HNODS), held in San Francisco, 23-24 Januar
Comment on Article Mentions: Michelson Diagnostics Jon Holmes Michelson Diagnostics EX1301
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Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia
Explore Article SPIE Digital Library (Mar 2 2010) Oncology , Urology
We consider the cross-polarization OCT (CP OCT) that is focused on comparison of images resulting from cross-polarization and co-polarization scattering simultaneously. This technique provides information about microstructural and biochemical alterations in depolarizing tissue components (collagen). We found that mature type I collagen gives a strong signal in orthogonal polarization. CP OCT images of benign inflammatory processes always feature signal in orthogonal polarization, with layers and borders persisting to be well defined. In the presence of precancerous alterations, signal in orthogonal polarization is available in the image but it is irregular, disappearing in some areas. A CP OCT image of bladder ...
Comment on Article Mentions: Nizhny Novgorod State Medical Academy Valentin M. Gelikonov Elena V. Zagaynova
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A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers
Explore Article SPIE Digital Library (Mar 2 2010) Dermatology , Oncology
Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical instrument for morphological and biochemical characterization of skin cancers with combined RS-OCT. The portable instrument utilizes independent RS and OCT system backbones, and is integrated in a common clinical probe. ...
Comment on Article Mentions: Anita Mahadevan-Jansen Ton G. van Leeuwen Academic Medical Center at the University of Amsterdam
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A dual modality fluorescence confocal and optical coherence tomography microendoscope
Explore Article SPIE Digital Library (Feb 24 2010) Endoscopy , Microscopy , Oncology
We demonstrate the implementation of a Fourier domain optical coherence tomography (OCT) imaging system incorporated into the optical train of a fluorescence confocal microendoscope. The slit-scanning confocal system has been presented previously and achieves 3µm lateral resolution and 25µm axial resolution over a field of view of 430µm. Its multi-spectral mode of operation captures images with 6nm average spectral resolution. To incorporate OCT imaging, a common-path interferometer is made with a super luminescent diode and a reference coverslip located at the distal end of the fiber bundle catheter. The infrared diode spectral width allows a theoretical OCT axial resolution of ...
Comment on Article Mentions: University of Arizona
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Clinical optical coherence tomography combined with multiphoton tomography for evaluation of several skin disorders
Explore Article SPIE Digital Library (Feb 19 2010) Dermatology , Oncology
The first clinical trial of optical coherence tomography (OCT) combined with multiphoton tomography (MPT) and dermoscopy is reported. State-of-the-art (i) OCT systems for dermatology (e.g. multibeam swept source OCT), (ii) the femtosecond laser multiphoton tomograph DermaInspectTM, and (iii) digital dermoscopes were applied to 47 patients with a diversity of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases. Dermoscopy, also called 'epiluminescent microscopy', provides two-dimensional color images of the skin surface. OCT imaging is based on the detection of optical reflections within the tissue measured interferometrically whereas nonlinear excitation ...
Comment on Article Mentions: Michelson Diagnostics Gordon Mckenzie
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Overcoming barriers in topical administration of gold nanoparticles for optical coherence tomography using multimodal delivery
Explore Article SPIE Digital Library (Feb 19 2010) Oncology , Otolaryngology
Optical coherence tomography (OCT) is a non-invasive and promising imaging modality with high resolution that is an order of magnitude higher than current diagnostic techniques. However, its use in detecting early-stage cancer is limited due to insufficient contrast level in biological tissue, which can be enhanced by harnessing contrast agents [e.g., gold nanoparticles (Au NPs)]. Enhanced penetration by creating micropassages and distribution by ultrasonic force (multimodal topical delivery) was proven to overcome two major barriers (stratum corneum and epithelial barriers) in topically administering Au NPs using an in vivo oral dysplasia hamster model (overall 150% enhanced OCT contrast). Expanded progress ...
Comment on Article Mentions: Zhongping Chen UC Irvine Petra Wilder-Smith
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Faster and More Accurate Tests Dramatically Increase Effectiveness of Cancer Treatment
Explore Article optimum-tech.com (Feb 17 2010) Oncology , Other Business News
New ways of looking for – and eliminating – cancer cells left behind after surgery to treat breast cancer could reduce the need for additional surgeries and increase a patient’s quality of life. Currently, many surgeons are simply going by what they can see during surgery, a method that leaves plenty of room for error and may encourage doctors to remove more tissue than necessary or, worse, leave some cancer behind. Dr. Nirmala Ramanujam, of the Biomedical Engineering department at Duke University, reported that as many as 40 percent of women who underwent surgery to remove a tumor still had ...Comment on Article Mentions: Optimum Technologies Inc.
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Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
Explore Article SPIE Digital Library (Feb 16 2010) Oncology , Urology
The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min. The therapeutical ...
Comment on Article Mentions: Nizhny Novgorod State Medical Academy Vladislav A. Kamensky Russian Academy of Sciences
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Great video Jim!
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Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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