1. Articles in category: Oncology

    1-24 of 644 1 2 3 4 ... 25 26 27 »
    1. PROSCOPE project aims for early-stage bowel cancer detection

      PROSCOPE project aims for early-stage bowel cancer detection

      Multimodal platform should allow cellular-level colon imaging in real-time. Improving diagnosis: PROSCOPE A project funded by the EU's Horizon 2020 program is on course to develop a new imaging system for the diagnosis of bowel cancer. PROSCOPE , officially titled "Point-of-care instrument for diagnosis and image-guided intervention of colorectal cancer," was launched in 2020 and backed by €6 million of EU funding. The project has now carried out an 18-month formal review, confirming that its research program is on target to help reduce the 160,000 deaths and €9 billion in healthcare costs associated with the disease. "Currently, only 14 ...

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    2. New imaging system to detect bowel cancer at the earliest stages using photonics

      New imaging system to detect bowel cancer at the earliest stages using photonics

      Early intervention could prevent many of the 160,000 deaths from colon cancer in Europe each year. Colonoscopies, the gold standard for spotting bowel cancer early, can still miss up to 20% of precancerous cells. But now, thanks to a pan-European health consortium, a new concept that uses photonics to help doctors spot bowel cancer could soon prevent up to half of these deaths and save €9 billion in reduced healthcare costs. No tools exist that can look inside the colon at the cellular level in real-time to give an immediate diagnosis. But now, this European research team based across ...

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    3. Identification of oral precancerous and cancerous tissue by swept source optical coherence tomography

      Identification of oral precancerous and cancerous tissue by swept source optical coherence tomography

      Background and objectives: Distinguishing cancer from precancerous lesions is critical and challenging in oral medicine. As a noninvasive method, optical coherence tomography (OCT) has the advantages of real-time, in vivo, and large-depth imaging. Texture information hidden in OCT images can provide an important auxiliary effect for improving diagnostic accuracy. The aim of this study is to explore a reliable and accurate OCT-based method for the screening and diagnosis of human oral diseases, especially oral cancer. Materials and methods: Fresh ex vivo oral tissues including normal mucosa, leukoplakia with epithelial hyperplasia (LEH), and oral squamous cell carcinoma (OSCC) were imaged intraoperatively ...

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    4. Validation of a Point-of-Care Optical Coherence Tomography Device with Machine Learning Algorithm for Detection of Oral Potentially Malignant and Malignant Lesions

      Validation of a Point-of-Care Optical Coherence Tomography Device with Machine Learning Algorithm for Detection of Oral Potentially Malignant and Malignant Lesions

      Non-invasive strategies that can identify oral malignant and dysplastic oral potentially-malignant lesions (OPML) are necessary in cancer screening and long-term surveillance. Optical coherence tomography (OCT) can be a rapid, real time and non-invasive imaging method for frequent patient surveillance. Here, we report the validation of a portable, robust OCT device in 232 patients (lesions: 347) in different clinical settings. The device deployed with algorithm-based automated diagnosis, showed efficacy in delineation of oral benign and normal ( n = 151), OPML ( n = 121), and malignant lesions ( n = 75) in community and tertiary care settings. This study showed that OCT images analyzed by automated ...

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    5. Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives a 2021 NIH Grant for $742,473 for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftima. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as ...

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    6. Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, current methods for capturing these microscopy images require resource intensive tissue preparation that may delay diagnosis for days or weeks. To streamline this process, clinicians are limited to assessing small macroscopically representative subsets of tissues. Here, a combined photoacoustic remote sensing (PARS) microscope and swept source optical coherence tomography system designed to circumvent these diagnostic limitations is presented. The proposed multimodal microscope provides label-free three-dimensional depth resolved virtual histology visualizations, capturing nuclear and extranuclear tissue morphology directly on thick unprocessed specimens. The capabilities of the proposed method are ...

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    7. Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography

      Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography

      The three-dimensional (3D) tumor spheroid model is a critical tool for high-throughput ovarian cancer research and anticancer drug development in vitro . However, the 3D structure prevents high-resolution imaging of the inner side of the spheroids. We aim to visualize and characterize 3D morphological and physiological information of the contact multicellular ovarian tumor spheroids growing over time. We intend to further evaluate the distinctive evolutions of the tumor spheroid and necrotic tissue volumes in different cell numbers and determine the most appropriate mathematical model for fitting the growth of tumor spheroids and necrotic tissues. A label-free and noninvasive swept-source optical coherence ...

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    8. Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography

      Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography

      Patient-derived cancer organoids (PCOs) are in vitro organotypic models that reflect in vivo drug response, thus PCOs are an accessible model for cancer drug screening in a clinically relevant timeframe. However, current methods to assess the response of PCOs are limited. Here, a custom swept-source optical coherence tomography (OCT) system was used to rapidly evaluate volumetric growth and drug response in PCOs. This system was optimized for an inverted imaging geometry to enable high-throughput imaging of PCOs. An automated image analysis framework was developed to perform 3D single-organoid tracking of PCOs across multiple time points over 48 hours. Metabolic inhibitors ...

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    9. A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.

      A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.

      This is a data collection study involving the gathering of clinical data and OCT ( optical coherence tomography ) scans from 350 patients. The purpose of this study is to gather data to help develop an AI algorithm to detect eye abnormalities specifically those related to certain cancer treatments. At the end of the study interviews will be held with expert ophthalmologists to assess the acceptability of implementing AI into clinical practice.

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    10. Immediate preoperative FD-OCT used to measure ocular surface squamous neoplasia

      Immediate preoperative FD-OCT used to measure ocular surface squamous neoplasia

      Ocular surface squamous neoplasia encompasses the spectrum of pathological lesions ranging from preinvasive dysplasia to invasive squamous cell carcinoma. Recent advances in the evaluation and management of ocular surface squamous neoplasia (OSSN) have changed the trends in treatment protocols. There have been newer modalities of management such as immunotherapy and chemotherapy, but the gold standard is still surgical removal. However, there have always been setbacks due to unexplained recurrences.

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    11. Clinical significance of intracoronary optical coherence tomography examination in the fields of onco-cardiology/cardio-oncology

      Clinical significance of intracoronary optical coherence tomography examination in the fields of onco-cardiology/cardio-oncology

      Onco-cardiology or cardio-oncology is critically required to understand the optimal care of patients with cancer [ 1 , 2 , 3 ]. In this era of an aging society, the morbidity of cancer and coronary artery disease (CAD) is increasing, and both become the major causes of death. Significant links between cancer diseased and CAD have been reported [ [1] , [2] ]. CAD is identified as a risk factor in the prognosis of cancer survivors [ [3] ], while cancer is an independent predictor of poor CAD outcomes [ [4] ]. These findings might be attributed to the fact that advanced diagnosis and treatment could achieve good long-term outcomes in ...

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    12. Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images

      Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images

      In this study, we performed dual-modality optical coherence tomography (OCT) characterization (volumetric OCT imaging and quantitative optical coherence elastography) on human breast tissue specimens. We trained and validated a U-Net for automatic image segmentation. Our results demonstrated that U-Net segmentation can be used to assist clinical diagnosis for breast cancer, and is a powerful enabling tool to advance our understanding of the characteristics for breast tissue. Based on the results obtained from U-Net segmentation of 3D OCT images, we demonstrated significant morphological heterogeneity in small breast specimens acquired through diagnostic biopsy. We also found that breast specimens affected by different ...

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    13. Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model

      Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model

      Background: There is an urgent need to develop a non-invasive imaging technique for detecting colorectal dysplasia and cancer. Technology for early and real-time microscopic assessments to select the most representative biopsy sites would also be of clinical value. In this study, we explored the sensitivity of optical coherence tomography (OCT) in detecting local lesions to demonstrate its potential for the early detection of colorectal dysplasia and cancer. Methods: An azoxymethane/dextran sodium sulfate mouse model of colorectal carcinogenesis was utilized. Mice were imaged by OCT, and colorectal tissue sections were observed with hematoxylin and eosin staining. The results of the ...

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      Mentions: Fudan University
    14. Optical Technologies for the Improvement of Skin Cancer Diagnosis: A Review

      Optical Technologies for the Improvement of Skin Cancer Diagnosis: A Review

      The worldwide incidence of skin cancer has risen rapidly in the last decades, becoming one in three cancers nowadays. Currently, a person has a 4% chance of developing melanoma, the most aggressive form of skin cancer, which causes the greatest number of deaths. In the context of increasing incidence and mortality, skin cancer bears a heavy health and economic burden. Nevertheless, the 5-year survival rate for people with skin cancer significantly improves if the disease is detected and treated early. Accordingly, large research efforts have been devoted to achieve early detection and better understanding of the disease, with the aim ...

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    15. Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats

      Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats

      Optical coherence tomography (OCT) of the ex vivo rat and human brain tissue samples is performed. The set of samples comprises intact white and gray matter, as well as human brain gliomas of the World Health Organization (WHO) Grades I-IV and glioma model 101.8 from rats. Analysis of OCT signals is aimed at comparing the physically reasonable properties of tissues, and determining the attenuation coefficient, parameter related to effective refractive index, and their standard deviations. Data analysis is based on the linear discriminant analysis and estimation of their dispersion in a four-dimensional principal component space. The results demonstrate the ...

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    16. Diagnostic Accuracy of Cross-Polarization OCT and OCT-Elastography for Differentiation of Breast Cancer Subtypes: Comparative Study

      Diagnostic Accuracy of Cross-Polarization OCT and OCT-Elastography for Differentiation of Breast Cancer Subtypes: Comparative Study

      The possibility to assess molecular-biological and morphological features of particular breast cancer types can improve the precision of resection margin detection and enable accurate determining of the tumor aggressiveness, which is important for treatment selection. To enable reliable differentiation of breast-cancer subtypes and evaluation of resection margin, without performing conventional histological procedures, here we apply cross-polarization optical coherence tomography (CP-OCT) and compare it with a novel variant of compressional optical coherence elastography (C-OCE) in terms of the diagnostic accuracy (Ac) with histological verification. The study used 70 excised breast cancer specimens with different morphological structure and molecular status (Luminal A ...

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    17. Statistical evaluation of reader variability in assessing the diagnostic performance of optical coherence tomography

      Statistical evaluation of reader variability in assessing the diagnostic performance of optical coherence tomography

      Significance: Optical coherence tomography (OCT) is widely used as a potential diagnostic tool for a variety of diseases including various types of cancer. However, sensitivity and specificity analyses of OCT in different cancers yield results varying from 11% to 100%. Hence, there is a need for more detailed statistical analysis of blinded reader studies. Aim: Extensive statistical analysis is performed on results from a blinded study involving OCT of breast tumor margins to assess the impact of reader variability on sensitivity and specificity. Approach: Five readers with varying levels of experience reading OCT images assessed 50 OCT images of breast ...

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    18. Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

      Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

      The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT). Another key question is whether subclinical OCT detected skin damage correlates with acute and late clinical toxicity.

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    19. Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

      Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

      Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs) are incorporated into cysteine-based poly-(disulfide amide) (Cys-PDSA) to form stable and biodegradable nanoagent. The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles (NPs) as a novel contrast agent for high-resolution ...

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    20. The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors

      The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors

      Histopathologic surgical margin assessment in veterinary patients is an imprecise science with assessment limited to a small proportion of the surgical margin due to time and finances. Incomplete excision of canine mast cell tumors (MCTs) alters treatment recommendations and prognosis. Optical coherence tomography (OCT) is a novel imaging modality that has been reported in a single veterinary study for surgical margin assessment. Twenty‐five dogs with 34 MCTs were enrolled in a prospective pilot‐study to assess the imaging characteristics of canine MCTs with OCT and to evaluate the feasibility and utility of OCT‐guided histopathology. All dogs underwent routine ...

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    21. Automated full-field polarization-sensitive optical coherence tomography diagnostic systems for breast cancer

      Automated full-field polarization-sensitive optical coherence tomography diagnostic systems for breast cancer

      Intraoperative delineation of breast cancer is a major challenge. An effective breast tissue screening technique may reduce the risk of re-excision during surgery by specifically identifying positive margins. In this study, a high-resolution automated full-field polarization-sensitive optical coherence tomography (FF-PS-OCT) system was developed to classify healthy and malignant human breast tissue from quantitative phase retardation information of the tissues in ex vivo . Twelve breast tissue samples [four healthy, eight malignant (cancerous)] were imaged with the FF-PS-OCT system and the different phase features were extracted from the acquired OCT images (106), based on the differences in the optical signatures of the ...

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    22. Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography

      Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography

      Detection of oral dysplastic and early-stage cancerous lesions is difficult with the current tools. Half of oral cancers are diagnosed in a late stage. Detection of early stromal change to predict malignant transformation is a new direction in the diagnosis of early-stage oral cancer. The application of new optical tools to image stroma in vivo is under investigation, and polarization-sensitive optical coherence tomography (PS-OCT) is potentially one of those tools. This is a preliminary study to sequentially image oral stromal changes from normal, hyperplasia, and dysplasia to early-stage cancer by PS-OCT in vivo. We used 4-Nitroquinoline-1-oxide drinking water to induce ...

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    23. Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery

      Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery

      Background Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full‐field optical coherence tomography (FFOCT) and dynamic cell imaging (DCI) are novel optical imaging techniques offering rapid histologic approximations that are unfettered by requisite handling steps. This study was conducted to determine the feasibility and diagnostic utility of FFOCT and DCI in examining breast and lymph node specimens during breast cancer surgery. Methods FFOCT and DCI were applied to normal and cancerous breast tissue, benign breast lesions, and resected axillary ...

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      Mentions: Aquyre Biosences
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