Popular Articles
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Organizations in the News
(13 articles) University of Illinois at Urbana-Champaign
(9 articles) University of Arizona
(9 articles) University College Hospital
(6 articles) University of Copenhagen
(6 articles) UK National Physical Laboratory
(6 articles) University of Toronto
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People in the News
(11 articles) Stephen A. Boppart
(7 articles) Jennifer K. Barton
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Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry
Explore Article opticsinfobase.org (Aug 25 2010)
Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated ...
Comment on Article Mentions: Francisco E. Robles Yizheng Zhu Duke University
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Changes and Current State of Diagnosis of Lung Cancer After Development of the Flexible Bronchofiberscope
Explore Article Oxford Journals (Aug 24 2010)
The flexible bronchofiberscope developed by Ikeda et al. has brought about revolutionary changes in the diagnosis and treatment of lung cancer. Advances in this device are continuing to emerge and lesions even smaller than those visible to the naked eye can now be visualized. In addition, the use of ultrasound now enables diagnosis of extramural bronchial lesions. Bronchoscopy is also used for the treatment of early hilar lung cancer, and in patients with airway stenosis due to advanced cancer, laser therapy, brachytherapy, and stenting can be performed. The bronchofiberscope is also very useful for tissue sampling from the lung periphery. ...
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Parametric imaging of cancer with optical coherence tomography
Explore Article SPIE Digital Library (Aug 19 2010)
We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images.
Comment on Article Mentions: University of Western Australia Steven L. Jacques Loretta Scolaro
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Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography
Explore Article The Journal of Urology (Aug 17 2010)
Purpose: We examined the usefulness of 3-dimensional optical coherence tomography to enhance the diagnosis of urothelial carcinoma in situ.Materials and Methods: By expressing SV40T antigen with uroplakin II promoter, carcinoma in situ readily develops in SV40T transgenic mice at about ages 8 to 20 weeks and then frank high grade papillary carcinoma develops in bladder epithelium. We examined 10 control and 40 SV40T mice during weeks 8 to 20 after birth by parallel en face white light imaging and 3-dimensional optical coherence tomography, and compared results with histology findings. We applied quantitative analysis of computer aided detection to 3-dimensional tomography ...
Comment on Article Mentions: SUNY at Stony Brook Yingtian Pan
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Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)
Explore Article IEEE Xplore (Aug 9 2010)
Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.
Comment on Article Mentions: University of Maryland Johns Hopkins University Yu Chen
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Conference Report: Eighth Annual AACR International Conference on Frontiers in Cancer Prevention Research
Explore Article Cancer Prevention Research (Aug 5 2010)
The Eighth Annual Frontiers in Cancer Prevention Research meeting was held in Houston, Texas, in November 2009. This report highlights significant presentations that advance the fields of chemoprevention, clinical trial recruitment and retention, cancer screening including optical imaging, energy balance, and nutritional epidemiology, and health communications and decision making. In findings from the randomized Reduction by Dutasteride of Prostate Cancer Events trial, dutasteride reduced the risk of biopsy-detectable prostate cancer in high-risk men by 23% compared with placebo. Important clues about the dosing and window of susceptibility for supplementation with choline, vitamin D, and folate were revealed from epigenetic research ...
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The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs
Explore Article CA: A Cancer Journal for Clinicians (Jul 30 2010)
Early detection of malignant melanoma remains the key factor in lowering mortality from this cancer. Recognizing the importance of this issue 25 years ago, our group at New York University published in CA: A Cancer Journal for Clinicians the mnemonic "ABCD" to facilitate the early diagnosis of melanoma. Studies have demonstrated the usefulness of this paradigm in enhancing early melanoma diagnosis as a part of clinical examinations, mass screenings, and public education programs. Approaches to melanoma diagnosis have dynamically evolved during the ensuing quarter century. In the 1990s, dermoscopy enabled the recognition of new subsurface features to differentiate between malignant ...
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Jennifer Barton is one women who wears many hats at University of Arizona
Explore Article azbiz.com (Jul 30 2010)
The University of Arizona’s Jennifer Barton is the assistant director and No. 3 person at Bio5 Institute, she is the department head of the newly established Department of Biomedical Engineering, chair of the Biomedical Engineering Graduate Interdisciplinary Program, and she is a researcher and teaches classes within optics, electrical and computer engineering and biomedical engineering. “Most faculty members end up teaching, doing research and some sort of service,” said Barton, who is also a Arizona Cancer Center member. “My service just happens to be more administrative. It seems like a lot but althugh I wear a lot of different hats, ...
Comment on Article Mentions: Jennifer K. Barton University of Texas at Austin University of Arizona
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Endoscopically guided spectral-domain OCT with double-balloon catheters
Explore Article opticsinfobase.org (Jul 30 2010)
Fourier-domain optical coherence tomography (OCT) and balloon-based catheters have furthered the potential of OCT as a real-time surveillance tool for Barrett’s esophagus (BE). However, a balloon catheter, which expands the esophagus and centers the catheter, applies direct pressure on the esophagus. This may affect the tissue appearance and the ability to detect dysplasia in BE. To study this effect, we propose a double-balloon catheter to allow imaging with and without balloon-tissue contact. A system design based on a spectral-domain OCT platform is reported and validated by acquisition of high quality, volumetric images of swine esophagus in vivo.
Comment on Article Mentions: Hui Wang Michael W. Jenkins Andrew M. Rollins
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Visualization: Imaging and Cancer Treatment
Explore Article YouTube (Jun 24 2010)
Dr. Utkarsh Sharma and Dr. Steven Adie, both of the University of Illinois' Beckman Institute for Advanced Science and Technology, discuss imaging and cancer treatment at Innovators Improv on April 29, 2010 at Radio Maria in Champaign, IL. The Champaign-Urbana culture inspires innovation and creativity. The Innovators Improv™ is a mechanism to engage innovative and creative individuals within the community to express and develop their ideas and concepts and to stimulate synergistic networks.
Comment on Article Mentions: University of Illinois at Urbana-Champaign Steven G. Adie Utkarsh Sharma
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The origins of urothelial carcinoma
Explore Article Expert Reviews (Jun 17 2010)
Expert Review of Anticancer Therapy , June 2010, Vol. 10, No. 6, PaIt is now widely believed that there are two major pathways for urothelial carcinogenesis. One pathway usually involves mutation of FGF receptor 3 and gives rise to low-grade papillary tumors that frequently recur but seldom invade. By contrast, high-grade urothelial malignancies, including high-grade papillary urothelial carcinoma and urothelial carcinoma in situ (CIS) usually exhibit deletions or mutations of TP53. Urothelial CIS is the most likely precursor of high-grade invasive bladder cancer. It is a ‘flat lesion’ that may be relatively inconspicuous at cystoscopy, or even endoscopically undetectable. The ...
Comment on Article Mentions: Case Western Reserve University Indiana University
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Spectral-domain optical coherence tomography of conjunctival mucosa-associated lymphoid tissue lymphoma with presumed choroidal involvement
Explore Article SpringerLink Home (Jun 7 2010)
Background Conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma has been well-described, but rarely do these lesions demonstrate intraocular involvement. We report a case of conjunctival MALT lymphoma with intraocular involvement and novel spectral-domain ocular coherence tomography (SD-OCT) findings. Patient and methods A 75-year-old woman with biopsy-proven MALT lymphoma of the conjunctiva presented with ipsilateral yellowish diffuse choroidal infiltrates on fundoscopic examination. Choroidal involvement was documented clinically, on ultrasonography, on fluorescein angiography, and by SD-OCT. Treatment consisted of 3 weeks of oral doxycycline and six cycles of systemic chemotherapy with cyclophosphamide, vincristine, prednisone, and rituximab. Results There was no evidence of progression ...
Comment on Article Mentions: Carl Zeiss Meditec David Geffen School of Medicine Zeiss Cirrus HD-OCT
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Imaging of periocular basal cell carcinoma using en face optical coherence tomography: a pilot study
Explore Article BJO Online (Jun 1 2010)
Aim To use en face optical coherence tomographic (OCT) imaging to identify features of tumour tissue and their correlation with histopathologic findings and to assess the effect of different wavelengths and resolutions of OCT in identifying tumour boundaries and features. Methods Excision specimens of consecutive biopsy-proven periocular basal cell carcinomas (BCCs) (n=8) were assessed by OCT, performing in vitro cross-section and en face scans of the tissues. Images were collected from three different machines: systems 1 and 2 had a wavelength of 1300 nm, and system 3 had a wavelength of 840 nm. System 2 used high numerical aperture interface ...
Comment on Article Mentions: University of Kent Adrian G. Podoleanu
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Utilization of Optical Coherence Tomography (OCT) in the Diagnosis of an Iris Tapioca Tumor
Explore Article Optometry (May 31 2010)
Background: Tapioca-like tumors represent rare vascularized lesions of the iris. The tumors may be benign (tapioca nevus) or malignant (tapioca melanoma). Histopathologic studies have demonstrated epithelial and spindle cellular composition. Clinically, the lesions are characterized as multinodular, lightly pigmented lesions. Progressive growth may result in secondary glaucoma. Additionally, malignant lesions have demonstrated metastasis. Prompt clinical recognition facilitates determination of lesion malignancy via needle biopsy for histological/immune-histological assessment. Optical Coherence Tomography (OCT) represents a noninvasive imaging device which may facilitate diagnosis of a tapioca tumor. OCT, in conjunction with Ultrasound Biomicroscopy (UBM), provides serial qualitative and quantitative characterization of the lesion ...
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Michelson Diagnostic’s Multi Beam OCT technology to Provide Significant Cost Savings for Treating Non-Melanoma Skin Cancer
Explore Article Optical Coherence Tomography News (Apr 29 2010)
(Orpington, UK) April 29, 2010 – At a time where non-melanoma skin cancer is reaching epidemic proportions in the U.S, accounting for 4.5% of all Medicare cancer costs; there is a new breakthrough in skin imaging that is predicted to provide significant cost savings. Michelson Diagnostics, a leading innovator in Multi-Beam Optical Coherence Tomography (OCT) products, has developed the VivoSight scanner, which has shown great potential in pre-operation delineation of tumor margins in skin cancer patients. The scanner, which received 510 FDA Clearance in January, is able to provide extraordinarily high resolution images of tumors in real-time, to improve excision ...
Comment on Article Mentions: Michelson Diagnostics Jon Holmes Michelson Diagnostics Vivosight
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Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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