1. Articles in category: Oncology

    1-24 of 654 1 2 3 4 ... 26 27 28 »
    1. Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study

      Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study

      Background and Aims Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Since these alterations predate the development of dysplasia, we aimed to utilize nanoNAM to identify patients with Barrett’s esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Methods This is a nested case control study of 46 BE patients of which 21 progressed to HGD/EAC over 3.7 (± 2.37) years (cases/progressors) and 25 patients who did not progress ...

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    2. Researchers pilot 'itty bitty' device for earlier ovarian cancer detection

      Researchers pilot 'itty bitty' device for earlier ovarian cancer detection

      Due to a lack of effective screening and diagnostic tools, more than three-fourths of ovarian cancer cases are not found until the cancer is in an advanced stage. As a result, fewer than half of all women with ovarian cancer survive more than five years after diagnosis. Jennifer Barton , director of the University of Arizona BIO5 Institute and Thomas R. Brown Distinguished Chair in Biomedical Engineering , has spent years developing a device small enough to image the fallopian tubes – narrow ducts connecting the uterus to the ovaries – and search for signs of early-stage cancer. Dr. John Heusinkveld has now used ...

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    3. Perimeter Medical Imaging AI Announces Initiation of First Clinical Trial Site at West Cancer Center & Research Institute in Tennessee

      Perimeter Medical Imaging AI Announces Initiation of First Clinical Trial Site at West Cancer Center & Research Institute in Tennessee

      Perimeter Medical Imaging AI, Inc., a medical technology company driven to transform cancer surgery with ultra-high-resolution, real-time, advanced imaging tools to address high unmet medical needs, announced the initiation of a multi-center, randomized, two-arm pivotal clinical trial to evaluate its Perimeter B-Series OCT with ImgAssist AI for use during breast conservation surgery. The first patient procedures were performed by Richard E. Fine, MD and Michael Berry, MD, leading breast surgeons based out of the Margaret West Comprehensive Breast Center in Germantown, Tennessee. Dr. Richard E. Fine, Director of Education & Research, Margaret West Comprehensive Breast Center, West Cancer Center & Research Institute ...

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    4. The “Virtual Biopsy” of Cancerous Lesions in 3D: Non-Invasive Differentiation between Melanoma and Other Lesions Using Vibrational Optical Coherence Tomography

      The “Virtual Biopsy” of Cancerous Lesions in 3D: Non-Invasive Differentiation between Melanoma and Other Lesions Using Vibrational Optical Coherence Tomography

      Early detection of skin cancer is of critical importance to provide five year survival rates that approach 99%. By 2050, one out of five Americans by age 70 will develop some form of skin cancer. This will result in a projected rate of 50 million skin biopsies per year given the current rate of escalation. In addition, the ability to differentiate between pigmented lesions and melanomas has proven a diagnostic challenge. While dermoscopy and visual analysis are useful in identifying many skin lesions, additional non-invasive techniques are needed to assist in the analysis of difficult to diagnose skin tumors. To ...

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      Mentions: OptoVibronex
    5. Potential Utility of Adjunct Imaging with Wide-Field Optical Coherence Tomography for Gross and Microscopic Evaluation of Breast Specimens in Real-Time in the Operating Suite

      Potential Utility of Adjunct Imaging with Wide-Field Optical Coherence Tomography for Gross and Microscopic Evaluation of Breast Specimens in Real-Time in the Operating Suite

      One challenge in the surgical management of breast cancer is maximizing the preservation of healthy tissue while achieving acceptable negative margins. Tools capable of assessing disease-margin involvement intraoperatively and in real-time could provide clinically useful guidance regarding the adequacy of margin resection before the surgery is over. Here we report the intraoperative use of optical coherence tomography (OCT) in 3 patients with DCIS. In all 3 cases, additional lesions identified by OCT during surgery were also noted in histopathology reports 3 to 5 days post-surgery, suggesting that intraoperative use of OCT is a valuable tool for margin determination in real-time.

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    6. Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions?

      Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions?

      Early detection of skin cancer is of critical importance since the five-year survival rate for early detected skin malignancies is 99% but drops to 27% for cancer that has spread to distant lymph nodes and other organs. Over 2.5 million benign skin biopsies (55% of the total) are performed each year in the US at an alarming cost of USD ~2.5 B. Therefore there is an unmet need for novel non-invasive diagnostic approaches to better differentiate between cancerous and non-cancerous lesions, especially in cases when there is a legitimate doubt that a biopsy may be required. The purpose ...

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    7. Spotting colon cancer early with the 'Google Earth of colonoscopies'

      Spotting colon cancer early with the 'Google Earth of colonoscopies'

      A new optical imaging system in the works could revolutionize the diagnosis of colon cancer. Currently, colonoscopies only manage to detect 39 % of bowel cancer cases in the early stages. Now, the EU-funded PROSCOPE project's novel screening platform has the potential to save up to half of the 160 000 lives lost in Europe every year because of this disease. Today's colonoscopy procedures are based on white light video or optical narrow-band imaging.

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    8. High-Risk, High-Reward grants awarded to three Stanford researchers

      High-Risk, High-Reward grants awarded to three Stanford researchers

      Winetraub’s research focuses on utilizing Optical Coherence Tomography and machine learning to image cancer non-invasively at a single-cell resolution. Currently, detecting most solid cancers and confirming the boundaries – or margins – of the tumor often entails analyzing chemically stained sections of tissue that are obtained via biopsy. Winetraub and members of the de la Zerda group at Stanford have recently developed a virtual version of this process. The NIH award will support further work on this project. “This imaging modality provides real-time diagnosis of tumor margins and invasiveness by scanning a large tissue area for residual cancer cells. Such information ...

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    9. Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors

      Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors

      The incidence of skin cancer has been continuously increasing over the past decades und the number of non melanoma skin cancer is well as melanoma is still going to increase. Invasive biopsy and histological examination represents the gold standard in diagnosis of benign and malignant skin tumors. However, novel technologies such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) have been introduced in dermatology. Multiple studies have shown the applicability of both technologies for diagnosis of skin tumors as well as other skin diseases and to increase the specificity of diagnosis resulting in the reduction of unnecessary biopsies ...

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    10. Researchers use deep learning to enhance cancer diagnostic tools

      Researchers use deep learning to enhance cancer diagnostic tools

      Yi “Edwin” Sun, a Ph.D. candidate in electrical and computer engineering at the University of Illinois Urbana-Champaign and member of the Beckman Institute’s Biophotonics Imaging Laboratory headed by Stephen Boppart, explored how deep learning methods can make polarization-sensitive optical coherence tomography, or PS-OCT, more cost-effective and better equipped to diagnose cancer in biological tissues. The paper, titled “ Synthetic polarization-sensitive optical coherence tomography by deep learning ,” was published in npj Digital Medicine. OCT systems are common clinically and are used to generate high-resolution cross-sectional images of regions in the human body. Sun and his team developed a groundbreaking method ...

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    11. PROSCOPE project aims for early-stage bowel cancer detection

      PROSCOPE project aims for early-stage bowel cancer detection

      Multimodal platform should allow cellular-level colon imaging in real-time. Improving diagnosis: PROSCOPE A project funded by the EU's Horizon 2020 program is on course to develop a new imaging system for the diagnosis of bowel cancer. PROSCOPE , officially titled "Point-of-care instrument for diagnosis and image-guided intervention of colorectal cancer," was launched in 2020 and backed by €6 million of EU funding. The project has now carried out an 18-month formal review, confirming that its research program is on target to help reduce the 160,000 deaths and €9 billion in healthcare costs associated with the disease. "Currently, only 14 ...

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    12. New imaging system to detect bowel cancer at the earliest stages using photonics

      New imaging system to detect bowel cancer at the earliest stages using photonics

      Early intervention could prevent many of the 160,000 deaths from colon cancer in Europe each year. Colonoscopies, the gold standard for spotting bowel cancer early, can still miss up to 20% of precancerous cells. But now, thanks to a pan-European health consortium, a new concept that uses photonics to help doctors spot bowel cancer could soon prevent up to half of these deaths and save €9 billion in reduced healthcare costs. No tools exist that can look inside the colon at the cellular level in real-time to give an immediate diagnosis. But now, this European research team based across ...

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    13. Identification of oral precancerous and cancerous tissue by swept source optical coherence tomography

      Identification of oral precancerous and cancerous tissue by swept source optical coherence tomography

      Background and objectives: Distinguishing cancer from precancerous lesions is critical and challenging in oral medicine. As a noninvasive method, optical coherence tomography (OCT) has the advantages of real-time, in vivo, and large-depth imaging. Texture information hidden in OCT images can provide an important auxiliary effect for improving diagnostic accuracy. The aim of this study is to explore a reliable and accurate OCT-based method for the screening and diagnosis of human oral diseases, especially oral cancer. Materials and methods: Fresh ex vivo oral tissues including normal mucosa, leukoplakia with epithelial hyperplasia (LEH), and oral squamous cell carcinoma (OSCC) were imaged intraoperatively ...

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    14. Validation of a Point-of-Care Optical Coherence Tomography Device with Machine Learning Algorithm for Detection of Oral Potentially Malignant and Malignant Lesions

      Validation of a Point-of-Care Optical Coherence Tomography Device with Machine Learning Algorithm for Detection of Oral Potentially Malignant and Malignant Lesions

      Non-invasive strategies that can identify oral malignant and dysplastic oral potentially-malignant lesions (OPML) are necessary in cancer screening and long-term surveillance. Optical coherence tomography (OCT) can be a rapid, real time and non-invasive imaging method for frequent patient surveillance. Here, we report the validation of a portable, robust OCT device in 232 patients (lesions: 347) in different clinical settings. The device deployed with algorithm-based automated diagnosis, showed efficacy in delineation of oral benign and normal ( n = 151), OPML ( n = 121), and malignant lesions ( n = 75) in community and tertiary care settings. This study showed that OCT images analyzed by automated ...

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    15. Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives a 2021 NIH Grant for $742,473 for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftima. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as ...

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    16. Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, current methods for capturing these microscopy images require resource intensive tissue preparation that may delay diagnosis for days or weeks. To streamline this process, clinicians are limited to assessing small macroscopically representative subsets of tissues. Here, a combined photoacoustic remote sensing (PARS) microscope and swept source optical coherence tomography system designed to circumvent these diagnostic limitations is presented. The proposed multimodal microscope provides label-free three-dimensional depth resolved virtual histology visualizations, capturing nuclear and extranuclear tissue morphology directly on thick unprocessed specimens. The capabilities of the proposed method are ...

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    17. Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography

      Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography

      The three-dimensional (3D) tumor spheroid model is a critical tool for high-throughput ovarian cancer research and anticancer drug development in vitro . However, the 3D structure prevents high-resolution imaging of the inner side of the spheroids. We aim to visualize and characterize 3D morphological and physiological information of the contact multicellular ovarian tumor spheroids growing over time. We intend to further evaluate the distinctive evolutions of the tumor spheroid and necrotic tissue volumes in different cell numbers and determine the most appropriate mathematical model for fitting the growth of tumor spheroids and necrotic tissues. A label-free and noninvasive swept-source optical coherence ...

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    18. Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography

      Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography

      Patient-derived cancer organoids (PCOs) are in vitro organotypic models that reflect in vivo drug response, thus PCOs are an accessible model for cancer drug screening in a clinically relevant timeframe. However, current methods to assess the response of PCOs are limited. Here, a custom swept-source optical coherence tomography (OCT) system was used to rapidly evaluate volumetric growth and drug response in PCOs. This system was optimized for an inverted imaging geometry to enable high-throughput imaging of PCOs. An automated image analysis framework was developed to perform 3D single-organoid tracking of PCOs across multiple time points over 48 hours. Metabolic inhibitors ...

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    19. A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.

      A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.

      This is a data collection study involving the gathering of clinical data and OCT ( optical coherence tomography ) scans from 350 patients. The purpose of this study is to gather data to help develop an AI algorithm to detect eye abnormalities specifically those related to certain cancer treatments. At the end of the study interviews will be held with expert ophthalmologists to assess the acceptability of implementing AI into clinical practice.

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    20. Immediate preoperative FD-OCT used to measure ocular surface squamous neoplasia

      Immediate preoperative FD-OCT used to measure ocular surface squamous neoplasia

      Ocular surface squamous neoplasia encompasses the spectrum of pathological lesions ranging from preinvasive dysplasia to invasive squamous cell carcinoma. Recent advances in the evaluation and management of ocular surface squamous neoplasia (OSSN) have changed the trends in treatment protocols. There have been newer modalities of management such as immunotherapy and chemotherapy, but the gold standard is still surgical removal. However, there have always been setbacks due to unexplained recurrences.

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    21. Clinical significance of intracoronary optical coherence tomography examination in the fields of onco-cardiology/cardio-oncology

      Clinical significance of intracoronary optical coherence tomography examination in the fields of onco-cardiology/cardio-oncology

      Onco-cardiology or cardio-oncology is critically required to understand the optimal care of patients with cancer [ 1 , 2 , 3 ]. In this era of an aging society, the morbidity of cancer and coronary artery disease (CAD) is increasing, and both become the major causes of death. Significant links between cancer diseased and CAD have been reported [ [1] , [2] ]. CAD is identified as a risk factor in the prognosis of cancer survivors [ [3] ], while cancer is an independent predictor of poor CAD outcomes [ [4] ]. These findings might be attributed to the fact that advanced diagnosis and treatment could achieve good long-term outcomes in ...

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    22. Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images

      Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images

      In this study, we performed dual-modality optical coherence tomography (OCT) characterization (volumetric OCT imaging and quantitative optical coherence elastography) on human breast tissue specimens. We trained and validated a U-Net for automatic image segmentation. Our results demonstrated that U-Net segmentation can be used to assist clinical diagnosis for breast cancer, and is a powerful enabling tool to advance our understanding of the characteristics for breast tissue. Based on the results obtained from U-Net segmentation of 3D OCT images, we demonstrated significant morphological heterogeneity in small breast specimens acquired through diagnostic biopsy. We also found that breast specimens affected by different ...

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    23. Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model

      Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model

      Background: There is an urgent need to develop a non-invasive imaging technique for detecting colorectal dysplasia and cancer. Technology for early and real-time microscopic assessments to select the most representative biopsy sites would also be of clinical value. In this study, we explored the sensitivity of optical coherence tomography (OCT) in detecting local lesions to demonstrate its potential for the early detection of colorectal dysplasia and cancer. Methods: An azoxymethane/dextran sodium sulfate mouse model of colorectal carcinogenesis was utilized. Mice were imaged by OCT, and colorectal tissue sections were observed with hematoxylin and eosin staining. The results of the ...

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      Mentions: Fudan University
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