Oncology -Optical Coherence Tomography News

Articles in category: Oncology

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1. High-Definition Optical Coherence Tomography (HD-OCT)
  
  Explore Agfa HealthCare — May 17 2013 Dermatology , Oncology
  
  Munich Germany, Priv. Doz. Dr. Gerald Messer (Munich, Germany) makes use of an AGFA SKINTELL unit for test purpose. He is quite impressed about the new technologies performance, especially in diagnosis of non-melanoma skin cancer. A first test is so promising that a second closer look will be done with associated clinics in June. “The new High-Definition Optical Coherence Tomography (HD-OCT) technology will give the opportunity to diagnose actinic keratosis and basal cell carcinoma without intervention in an early stage where non-invasive therapies are promising”. Dr. Messer reported also some success from the DDG (Deutsche Dermatologische Gesellschaft) Congress that was ...
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  Mentions: AGFA Healthcare AGFA SKINTELL
2. Subsquamous intestinal metaplasia after ablation of Barrett's esophagus: frequency and importance
  
  Explore LWW Online May 16 2013 Gastroenterology , Oncology
  
  Purpose of review: This article reviews reports on the prevalence of subsquamous intestinal metaplasia (SSIM) in patients with Barrett's esophagus, and the implications of SSIM in the neoplastic progression of Barrett's esophagus to esophageal adenocarcinoma. Recent findings: Endoscopic eradication therapy for dysplastic Barrett's esophagus has become an encouraging alternative to esophagectomy or continued endoscopic surveillance. However, the presence of SSIM before and after ablation is concerning because this tissue may have potential for malignant progression, is not visible by conventional endoscopy, and may evade detection by random esophageal biopsy sampling methods. Advances in endoscopic high-resolution three-dimensional optical ...
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  Mentions: Harvard University Hiroshi Mashimo
3. University of Arizona Receives NIH Grant for Diagnosis of Ovarian Cancer by Confocal Microendoscopy.
  
  Explore Optical Coherence Tomography News May 11 2013 Gynecology , Oncology , Funding
  
  University of Arizona Received a 2013 NIH Grant for $65,063 for Diagnosis of Ovarian Cancer by Confocal Microendoscopy. The principal investigator is Arthur Gmitro. The program started in 2005 and ends in 2014. Below is a summary of the proposed work. The objective of this research is to further develop and clinically validate a real-time multispectral confocal microendoscope for in vivo diagnosis of ovarian cancer. The confocal microendoscope is a new type of instrument for visualizing tissue at the cellular level and has shown great promise for performing optical biopsy. Confocal microendoscopy has the potential to provide a physician ...
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  Mentions: National Institutes of Health University of Arizona
4. Imaging of non-tumorous and tumorous human brain tissues with full-field optical coherence tomography
  
  Explore ScienceDirect May 9 2013 Neurology , Oncology
  
  A prospective study was performed on neurosurgical samples from 18 patients to evaluate the use of full-field optical coherence tomography (FF-OCT) in brain tumor diagnosis. FF-OCT captures en face slices of tissue samples at 1 μm resolution in 3D to a penetration depth of around 200 μm. A 1 cm 2 specimen is scanned at a single depth and processed in about 5 min. This rapid imaging process is non-invasive and requires neither contrast agent injection nor tissue preparation, which makes it particularly well suited to medical imaging applications. Temporal chronic epileptic parenchyma and brain tumors such as meningiomas, low-grade ...
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  Mentions: Claude Boccara Fabrice Harms LLTech
5. In vitro study of the effects of ultrasound-mediated glycerol on optical attenuation of human normaland cancerous esophageal tissues with optical coherence tomography
  
  Explore IOPscience May 8 2013 Gastroenterology , Oncology
  
  Previous studies from our group have demonstrated that glucose solution can induce optical clearing enhancement of esophageal tissues with optical coherence tomography (OCT). The aims of this study were to evaluate the optical clearing effects of ultrasound-mediated optical clearing agents (OCAs) and to find more effective methods to distinguish human normal esophageal tissues (NE) and cancerous esophageal tissues (CE). Here we used the OCT technique to investigate the optical attenuation of NE and CE in vitro after treatment with 30% glycerol alone and glycerol combined with ultrasound, respectively. Experimental results showed that the averaged attenuation coefficient of CE was significantly ...
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  Mentions: Fujian Normal University South China Normal University
6. Feature Of The Week 4/21/13: University of Toronto Investigates Analysis of OCT Speckle to Differentiate Tissue Disease State
  
  Explore Optical Coherence Tomography News Apr 21 2013 Oncology
  
  Optical coherence tomography is playing an increasingly important role in the differentiation between normal and diseased tissue states in situ. While OCT’s resolution is typically on the micrometer scale and is generally insufficient for direct visualization of cellular organelles and cellular level changes, as these are submicrometer in size. Recently researchers at the University of Toronto, Sunnybrook Health Sciences Center, University Health Network, and National Research Council Canada published some interesting results investigating speckle which is highly correlated with the underlying scatterers’ average properties, such as size, shape, and distribution. Such an approach may give important information on sub-micrometer ...
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  Mentions: Ontario Cancer Institute University of Toronto Sunnybrook Health Sciences Centre
7. Telerobotic system designed to treat bladder cancer
  
  Explore News | Vanderbilt University Apr 6 2013 Oncology , Urology
  
  Although bladder cancer is the sixth most common form of cancer in the U.S. and the most expensive to treat, the basic method that doctors use to treat it hasn’t changed much in more than 70 years. An interdisciplinary collaboration of engineers and doctors at Vanderbilt and Columbia Universities intends to change that situation dramatically. Headed by Nabil Simaan , associate professor of mechanical engineering at Vanderbilt, the team has developed a prototype telerobotic platform designed to be inserted through natural orifices – in this case the urethra – that can provide surgeons with a much better view of bladder tumors ...
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  Mentions: Columbia University Vanderbilt University
8. Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation
  
  Explore jove.com Apr 6 2013 Oncology , Pulmonology
  
  Lung cancer is the leading cause of cancer-related deaths 1 . Squamous cell and small cell cancers typically arise in association with the conducting airways, whereas adenocarcinomas are typically more peripheral in location. Lung malignancy detection early in the disease process may be difficult due to several limitations: radiological resolution, bronchoscopic limitations in evaluating tissue underlying the airway mucosa and identifying early pathologic changes, and small sample size and/or incomplete sampling in histology biopsies. High resolution imaging modalities, such as optical frequency domain imaging (OFDI), provide non-destructive, large area 3-dimensional views of tissue microstructure to depths approaching 2 mm in ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
9. Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo
  
  Explore opticsinfobase.org Apr 3 2013 Oncology
  
  We demonstrate a method for differentiating tissue disease states using the intrinsic texture properties of speckle in optical coherence tomography (OCT) images of normal and tumor tissues obtained in vivo . This approach fits a gamma distribution function to the nonlog-compressed OCT image intensities, thus allowing differentiation of normal and tumor tissues in an ME-180 human cervical cancer mouse xenograft model. Quantitative speckle intensity distribution analysis thus shows promise for identifying tissue pathologies, with potential for early cancer detection in vivo .
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  Mentions: Ontario Cancer Institute University of Toronto Sunnybrook Health Sciences Centre
10. In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
  
  Explore Conference Proceedings Apr 1 2013 Gynecology , Oncology
  
  Our goal is to use optical coherence tomography (OCT) and multiphoton microscopy (MPM) to detect early tumor development in a mouse model of ovarian neoplasia. We hope to use information regarding early tumor development to create a diagnostic test for high-risk patients. In this study we collect in vivo images using OCT, second harmonic generation and two-photon excited fluorescence from non-vinylcyclohexene diepoxide (VCD)-dosed and VCD-dosed mice. VCD causes follicular apoptosis (simulating menopause) and leads to tumor development. Using OCT and MPM we visualized the ovarian microstructure and were able to see differences between non-VCD-dosed and VCD-dosed animals. This leads ...
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  Mentions: Jennifer K. Barton University of Arizona Robert R. Alfano
11. Optical biopsy of epithelial cancers by optical coherence tomography (OCT)
  
  Explore Home - Springer Mar 20 2013 Oncology
  
  Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study aims to summarize the principles of OCT and to discuss the current literature on the diagnostic value of OCT in the diagnosis of epithelial (pre)malignant lesions. The authors did ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
12. Measuring tissue elasticity for tumor detection
  
  Explore Home: SPIE.org Mar 15 2013 Oncology
  
  Optical coherence tomography combined with a focused air-puff system non-invasively assesses the mechanical properties of soft tissues and can be used to differentiate tumors during surgical treatment. Surgical resection is currently the most effective treatment for patients with soft-tissue tumors, which develop within connective tissues such as muscle and fat. To minimize the removal region and reduce the chance of recurrence, it is important to delineate the boundaries of the tumor prior to resection. As tumorigenesis involves a change in tissue stiffness, probing the mechanical properties (e.g. elasticity) of soft tissues could complement structural imaging (x-ray and magnetic resonance ...
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  Mentions: National Institutes of Health Kirill V. Larin University of Houston
13. Visual perception enhancement for detection of cancerous oral tissue by multi-spectral imaging
  
  Explore IOPscience Mar 7 2013 Oncology , Tunable Sources
  
  Color reproduction systems based on the multi-spectral imaging technique (MSI) for both directly estimating reflection spectra and direct visualization of oral tissues using various light sources are proposed. Images from three oral cancer patients were taken as the experimental samples, and spectral differences between pre-cancerous and normal oral mucosal tissues were calculated at three time points during 5-aminolevulinic acid photodynamic therapy (ALA-PDT) to analyze whether they were consistent with disease processes. To check the successful treatment of oral cancer with ALA-PDT, oral cavity images by swept source optical coherence tomography (SS-OCT) are demonstrated. This system can also reproduce images under ...
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  Mentions: National Taiwan University Meng-Tsan Tsai Chang Gung University
14. Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment
  
  Explore Optical Coherence Tomography News Mar 4 2013 Oncology , Funding
  
  Methodist Hospital Research Institute receives a $301,316 NIH grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment. The principal investigator is Seok-Hyun (Andy) Yun. The program is part of a multi-year program that started in 2012 and ends in 2014. Below is a summary of the work. Core 2 will provide the five projects with a number of unique advanced optical systems; collaborate with the project investigators in the design, execution, and analysis of animal experiments; and develop new instrumentation and methodology as needs arise. The Core will be established in Boston within the Wellman Center ...
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  Mentions: Seok-Hyun Yun National Institutes of Health Massachusetts General Hospital
15. Feature Of The Week 2/24/13: University of North Carolina uses OCT To Study Breast Cancer Morphology
  
  Explore Optical Coherence Tomography News Feb 24 2013 Oncology
  
  The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate morphology and size of organoids in 3D co-cultures of normal (MCF10A) or pre-malignant (MCF10DCIS.com) MEC and hTERT-immortalized fibroblasts from reduction mammoplasty (RMF). This co-culture model, based on an isogenic panel of cell lines, can yield insights to understand breast cancer progression. However, 3D cultures pose challenges for quantitative assessment and imaging, especially when the goal is to measure the same organoid structures over time. Using ...
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  Mentions: Amy L. Oldenburg University of North Carolina Raghav K. Chhetri
16. Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT
  
  Explore Wiley Online Library Feb 22 2013 Oncology
  
  The potential of OCT applied for early breast cancer detection attracted significant efforts. The permeability coefficients and the percentages of OCT signal enhancement for normal and cancerous breast tissues have been investigated from the experiments of 20% glucose, 40% glucose, and 20% mannitol in vitro. Obtained results indicate that the permeability coefficient in breast cancer tissue is prominently larger than that in normal breast tissue, while the optical clearing effect is just the reverse to that for each agent. The results suggest that OCT has the ability to distinguish cancer tissue from different aspect.
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  Mentions: Sun Yat-Sen University Tsinghua University Fujian Normal University
17. Differentiation of oral precancerous stages with optical coherence tomography based on theevaluation of optical scattering properties of oral mucosae
  
  Explore IOPscience Feb 15 2013 Oncology
  
  Optical coherence tomography (OCT) has been demonstrated to be a powerful tool for noninvasive, real-time oral cancer diagnosis. However, in previous reports, OCT has still been found to be difficult to use in the diagnosis of oral precancerous stages, including mild dysplasia and moderate dysplasia. In clinical applications, early diagnosis and treatment of oral cancer can greatly improve the survival rate. Therefore, in this study, we propose a new approach to differentiate the oral precancerous stages based on the evaluation of the optical scattering properties of the epithelial layer, which is where the dysplastic cells start to develop in the ...
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  Mentions: Chih-Chung Yang Meng-Tsan Tsai Chang Gung University
18. Optical Monitoring of Tumors in BALB/c Nude Mice Using Optical Coherence Tomography
  
  Explore opticsinfobase.org Feb 1 2013 Oncology
  
  We report a method for optical monitoring of tumors in an animal model using optical coherence tomography (OCT). In a spectral domain OCT system, a superluminescent diode light source with a full width of 66 nm at half maximum and peak wavelength of 950 nm was used to take images having an axial resolution of 6.8 μ m. Cancer cells of PC-3 were cultured and inoculated into the hypodermis of auricle tissues in BALB/c nude mice. We observed tumor formation and growth at the injection region of cancer cells in vivo and obtained the images of tumor mass center ...
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  Mentions: Thorlabs Sang-Won Lee Thorlabs OCT Imaging Systems
19. Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia
  
  Explore LWW Online Jan 27 2013 Gynecology , Oncology
  
  Objective: The study aimed to determine if the difference in cervical epithelium brightness, as measured by optical coherence tomography (OCT), has potential as a distinguishing characteristic of normal, low-grade, high-grade (cervical intraepithelial neoplasia 2+), and cancer histological findings. Materials and Methods: Information from 476 women was available for analysis. Demographic information was collected through in-person interview. All participants were human papillomavirus positive and/or had abnormal cytological finding and underwent colposcopy or unaided visual inspection and examination by OCT by quadrant. All women had a minimum of 4 OCT-matched cervical biopsies and endocervical curettage. Two sample t tests were used ...
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  Mentions: Andrew M. Rollins Imalux Case Western Reserve University
20. Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography
  
  Explore Ophthalmology Jan 21 2013 Oncology , Ophthalmology
  
  Purpose To assess the use of ultra–high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design Prospective, noncomparative, interventional case series. Participants Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention Ultra–high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures Clinical course and photographs, UHR OCT image, and histopathologic findings. Results Ultra–high-resolution OCT images of all ...
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  Mentions: Jianhua Wang University of Miami Sander R. Dubovy
21. A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy-induced oral mucositis
  
  Explore Wiley Online Library Jan 17 2013 Oncology
  
  Background and Objective Oral mucositis (OM) is a common and severe complication of many cancer therapies. Currently, prediction and early detection are not possible and objective monitoring remains problematic. Goal of this prospective study is to assess non-invasive imaging using optical coherence tomography (OCT) for early detection and evaluation of chemotherapy-induced OM in 48 patients, 12 of whom developed clinical mucositis. Study Design/Materials and Methods In 48 patients receiving neoadjuvant chemotherapy for primary breast cancer, oral mucosal health was assessed clinically, and imaged using non-invasive OCT. Images were evaluated for mucositis using an imaging-based scoring system ranging from 0 ...
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  Mentions: University of Pennsylvania UC Irvine Petra E. Wilder-Smith
22. Studies indicate that VivoSight OCT reliably predicts tumour margins
  
  Explore Optical Coherence Tomography News Jan 17 2013 Dermatology , Oncology
  
  Michelson Diagnostics Press Release - Accurate determination of tumour margins is vital to the successful treatment of skin cancer patients. This is especially the case for patients undergoing Mohs Micrographic Surgery where complete tumour removal may require repeated invasive procedures. Recent studies conducted in two US Healthcare facilities used the VivoSight OCT scanner, manufactured in the UK by Michelson Diagnostics Ltd, to prospectively refine clinically estimated tumour margins prior to Mohs Micrographic Surgery. The first 52 patient study 1 conducted by Professor Dan Seigel (Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York) concluded that: “OCT ...
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  Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight
23. Ex vivo high-definition optical coherence tomography of basal cell carcinoma compared to frozen-section histology in micrographic surgery: a pilot study
  
  Explore Wiley Online Library Jan 6 2013 Oncology
  
  Background Micrographic surgery is an established, but time-consuming operating procedure for facial basal cell carcinoma (BCC). A new high-definition (HD) optical coherence tomography (OCT) with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode allows a fast and non-invasive in vivo examination of BCC. Objectives To compare the diagnosis of BCC in excised tissue ex vivo by high-definition optical coherence tomography (HD-OCT) with the findings of frozen-section histology in micrographic surgery. Methods Twenty freshly excised BCC were examined by HD-OCT in the en-face and slice imaging mode divided into four sections each in concordance with ...
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24. Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer
  
  Explore SPIE | Journal Dec 19 2012 Dermatology , Oncology
  
  The importance of dermatological noninvasive imaging techniques has increased over the last decades, aiming at diagnosing nonmelanoma skin cancer (NMSC). Technological progress has led to the development of various analytical tools, enabling the in vivo/in vitro examination of lesional human skin with the aim to increase diagnostic accuracy and decrease morbidity and mortality. The structure of the skin layers, their chemical composition, and the distribution of their compounds permits the noninvasive photodiagnosis of skin diseases, such as skin cancers, especially for early stages of malignant tumors. An important role in the dermatological diagnosis and disease monitoring has been shown ...
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