1. Articles in category: Oncology

    1-24 of 500 1 2 3 4 ... 19 20 21 »
    1. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

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    2. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight ® , Callisto ® and Skintell ® . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness ...

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    3. Chicago startup raises $3M for probe to prevent repeat cancer surgeries

      Chicago startup raises $3M for probe to prevent repeat cancer surgeries

      A c hicago-based company has raised $3.1 million to fund a clinical trial for its high-resolution imaging probes for cancer surgeons. Diagnostic Photonics, which launched in 2011 at the University of Illinois at Urbana-Champaign, hopes its technology will prevent multiple surgeries for cancer patients. The company is focusing efforts first on breast cancer because about 25 percent of affected women undergo multiple surgeries after lumpectomy, according to a study conducted by the University of Wisconsin Carbone Cancer Center in Madison. The repeat surgeries are often spurred by the “challenges of where does the cancer stop and normal tissues start ...

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    4. Skin Cancer Biopsied by Optical Scan

      Skin Cancer Biopsied by Optical Scan

      Apollo Medical Optics Inc. (Taipei, Taiwan) aims to revolutionize skin cancer detection without the need for invasive biopsies by using a single-crystal sapphire and yttrium aluminium garnet crystalline fibers—surrounded by glass and a flexible polymer cladding—to look-through the skin and image suspicious skin anomalies non-invasively, instead of taking a skin sample and risk releasing malignant cancer cells into the bloodstream. The current prototype, using single-crystal sapphire at its core, is being integrated into a desktop unit that physicians can use in the office to identify skin cancer in a matter of minutes, determine its size and if small ...

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    5. Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Background and Objectives We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC). Methods A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports. Results The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively ...

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    6. Indo-US experts to develop solar-powered oral cancer detector

      Indo-US experts to develop solar-powered oral cancer detector

      Indian researchers along with US are working on a solar-powered device that could detect oral cancer at an early stage. It will enable faster and accurate diagnostics in rural areas through mobile technology. Designed by the Beckman Laser Institute (BLI), University of California-Irvine (UCI) and the Mazumdar Shaw Cancer Centre (MSCC) in Bengaluru, the compact screening and diagnosing system - slightly larger than a shoe box - has been specially adapted for India, which has one of the highest rates of head and neck cancers in the world and accounts for the highest rate among women. Its light-weight and user-friendly features mean ...

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    7. Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Objective : To determine the diagnostic accuracy of optical coherence tomography for basal cell carcinoma and the proportion of biopsies that could be avoided if optical coherence tomography is used to rule-in surgery. Design : Multicenter, prospective, observational study. Setting : Dermatology clinics. Participants : Consecutive patients with clinically challenging pink lesions suspicious for basal cell carcinoma. Measurements : Clinical, dermoscopic, and optical coherence tomography images were obtained for all subjects. At each stage, the clinician made a diagnosis (pathology + subtype if applicable), and assessed his/her own confidence in the diagnosis. Results : Optical coherence tomography significantly (p<0.01) improved sensitivity and specificity over ...

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    8. ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      Barrett’s esophagus (BE) is among the most common conditions encountered by the gastroenterologist. In this document, the American College of Gastroenterology updates its guidance for the best practices in caring for these patients. These guidelines continue to endorse screening of high-risk patients for BE; however, routine screening is limited to men with reflux symptoms and multiple other risk factors. Acknowledging recent data on the low risk of malignant progression in patients with nondysplastic BE, endoscopic surveillance intervals are attenuated in this population; patients with nondysplastic BE should undergo endoscopic surveillance no more frequently than every 3–5 years. Neither ...

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    9. 'Ultrasound Using Light' May Aid Tumor Removal

      'Ultrasound Using Light' May Aid Tumor Removal

      Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact—and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient's brain showing which areas are and are not cancer. A summary of the research appears in the June 17 issue of Science Translational Medicine . "As a neurosurgeon, I'm in agony when ...

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    10. Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Malignant tumor strongholds and their microscopic spies can’t hide in the thicket of flesh much longer, for surgeons have a new weapon: a device that sheds light on their location. Literally. “Any state of disease will alter the cells and molecules in our body,” said Dr. Stephen Boppart, a professor of bioengineering at the University of Illinois who invented the device. Every molecule scatters light different ways, he said, “leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave ...

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    11. Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography

      Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography

      Background: Full-field optical coherence tomography (FFOCT) is a real-time imaging technique that rapidly generates images reminiscent of histology without any tissue processing, warranting its exploration for evaluation of ex vivo kidney tissue. Methods: Fresh tissue sections from tumor and adjacent nonneoplastic kidney ( n = 25 nephrectomy specimens; clear cell renal cell carcinoma (CCRCC) = 12, papillary RCC (PRCC) = 4, chromophobe RCC (ChRCC) = 4, papillary urothelial carcinoma (PUC) = 1, angiomyolipoma (AML) = 2 and cystic nephroma = 2) were imaged with a commercial FFOCT device. Sections were submitted for routine histopathological diagnosis. Results: Glomeruli, tubules, interstitium, and blood vessels were identified in nonneoplastic tissue. In ...

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    12. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual presentation for the rapid identification of suspicious airway sites, while co-registered OCT provides detailed structural information to assess the airway morphology. We demonstrate the ability of AFI to visualize vascular ...

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    13. University of California at Davis Receives NIH Grant for The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotheraputics.

      University of California at Davis Receives NIH Grant for The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotheraputics.

      University of California at Davis Receives a 2015 NIH Grant for $584,839 for The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotheraputics. The principal investigator is Kit Lam. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The rodent eye as a non-invasive window for understanding cancer nanotherapeutics Abstract: We propose to use the mouse eye as a non-surgical window for highly efficient, optical investigation of subretinal xenograft models and nanodelivery, using a state-of-the-art ocular imager, "EyePod". The EyePod employs single-cell resolution intravital confocal microscopy and optical coherence tomography ...

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    14. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study - Ulrich - 2015 - British Journal of Dermatology - Wiley Online Library

      The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study - Ulrich - 2015 - British Journal of Dermatology - Wiley Online Library

      Background The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown. Objectives To investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy end point was a diagnosis of BCC for each lesion. Secondary end points were the diagnosis of other possible conditions. Methods This was an observational, prospective, multicentre study in which consecutive patients with nonpigmented pink lesions suspicious for BCC underwent clinical assessment, dermoscopy and OCT, with the diagnosis recorded at each stage. Once all diagnoses ...

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    15. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of tissue microstructure. Previous studies have demonstrated that OCT analysis of excised tissue specimens can distinguish between normal and cancerous tissues by identifying the heterogeneous and disorganized microscopic tissue structures indicative ...

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    16. New Imaging Technique Could Make Brain Tumor Removal Safer, More Effective, Study Suggests

      New Imaging Technique Could Make Brain Tumor Removal Safer, More Effective, Study Suggests

      Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact — and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient’s brain showing which areas are and are not cancer. A summary of the research appears June 17 in Science Translational Medicine . “As a neurosurgeon, I’m in agony when I’m taking ...

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    17. Sponge-like implant that traps cancer cells may improve early detection

      Sponge-like implant that traps cancer cells may improve early detection

      Researchers can predict where cancer cells tend to spread, but figuring out how to trap them has been tricky. A new device created by engineers at the University of Michigan may help, a study published Tuesday in the journal Nature Communications suggests. A new device created by engineers at the University of Michigan may help, a study published Tuesday in the journal Nature Communications suggests. The mechanism, described as a small, sponge-like implant that captures metastatic cancer cells, could help detect the disease in healthy patients and prevent relapse in survivors, said the engineers who created the device. “We set ...

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    18. Implant catches cancer cells moving through body

      Implant catches cancer cells moving through body

      Researchers have created an implant that soaks up metastatic cancer cells like a sponge, which researchers think could be used as an early warning system to detect the spread of cancer in a patient's body. The hope is for women at high risk for breast cancer, such as those who've had a tumor removed, could be monitored for the presence of cancer cells. Not only would this tip off doctors that a patient may have a recurrence of cancer, but they could analyze the cells to find the best course of treatment. "Breast cancer is a disease that ...

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    19. Multimodal imaging using optical coherence tomography and endolaryngeal ultrasonography in a new rabbit VX2 laryngeal cancer model

      Multimodal imaging using optical coherence tomography and endolaryngeal ultrasonography in a new rabbit VX2 laryngeal cancer model

      Background and Objective Optical coherence tomography (OCT) provides ultrahigh-resolution imaging of tissues within a depth of a few millimeters, whereas ultrasonography provides good imaging further below the surface. We aimed to develop a minimally invasive rabbit model of VX2 laryngeal cancer, suitable for these two imaging modalities through a transoral approach. We also sought to study the utility of combined OCT and endolaryngeal ultrasonography (EUS) for evaluation of early and advanced laryngeal cancer, using this model. Materials and Methods VX2 tumor suspension was inoculated into the vocal folds of ten rabbits by injection through the trans-thyrohyoid membrane. The tumor model ...

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    20. The University of Arizona Receives NIH Grant for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging

      The University of Arizona Receives NIH Grant for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging

      The University of Arizona Receives 2015 NIH Grant for $572,656 for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging. The principal invetigator is Jennifer Barton. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. Despite advances in treatment strategies, ovarian cancer remains the deadliest gynecological malignancy and the 5th largest cancer killer in women. Located deep in the body, with few early symptoms and no effective screening technique, ovarian cancer has remained stubbornly difficult to understand, much less effectively combat. Ovarian cancer is almost always discovered at ...

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    21. Medical images classication for skin cancer using quantitative image features with optical coherence tomography

      Medical images classication for skin cancer using quantitative image features with optical coherence tomography

      Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractal-based features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for differences between the skin tumors. A modified p value of < 0.001 was considered statistically significant. Significant increase of mean and median of intensity and significant decrease of mean and median of absolute gradient were observed in basal cell carcinomas ...

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    22. OCT helps identify cancerous brain tissue

      OCT helps identify cancerous brain tissue

      A brain cancer diagnosis can represent a death sentence, with remaining life measured in months to a year or so. Neurosurgery can increase the predicted survival time by up to 200%, depending upon the amount of tumour that can be resected. Distinguishing cancerous tissue from healthy brain tissue can be difficult, however, especially when it has infiltrated white matter. Current imaging detection technologies are suboptimal. Optical coherence tomography (OCT) offers the potential to identify cancerous brain tissue during surgery in an efficient and cost-effective manner. OCT can provide high-resolution volumetric imaging to a millimetre depth and deliver continuous, quantitative feedback ...

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    23. Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Optical coherence tomography (OCT) is a non-invasive imaging tool used in-vivo, in real time for diagnosis, treatment delineation and monitoring of basal cell carcinomas (BCC) treatment. Features of BCC on OCT have been widely described and reviewed. However, the diagnostic accuracy of OCT in these various applications are unclear. We systematically reviewed the literature to assess the accuracy of OCT in diagnosis and management of BCC using the Embase and Medline databases. 179 unique references were identified in the initial search. 22 studies with 556 histologically-proven BCC were eligible. Assessment of quality of eligible studies was undertaken using the STROBE ...

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    24. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Background A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes. Methods Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric ...

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    1-24 of 500 1 2 3 4 ... 19 20 21 »
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