Oncology -Optical Coherence Tomography News

Articles in category: Oncology

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1. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
  
  Explore Optical Coherence Tomography News Nov 10 2013 Oncology , Urology
  
  Optical Coherence Tomography (OCT) has proven a powerful tool for ophthalmologists to make clinical decisions for a wide range of blinding diseases and the there are now ~20 million ophthalmic OCT patient scans per year. Significant progress is also being made in intravascular imaging where OCT is emerging as a tool for both clinical decision making and the understanding of cardiovascular disease and development of new therapeutic tools. OCT also has the potential to impact the understanding, diagnosis, and treatment of some forms of cancer. There are many leading research groups around the world that are making excellent progress in ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
2. Detection of pH-induced aggregation of "smart" gold nanoparticles with photothermal optical coherence tomography
  
  Explore opticsinfobase.org Oct 28 2013 Oncology
  
  We report the feasibility of a novel contrast agent, namely “smart” gold nanoparticles (AuNPs), in the detection of cancer cells with photothermal optical coherence tomography (PT-OCT). “Smart” AuNPs form aggregation in low pH condition, which is typical for cancer cells, and this aggregation results in a shift of their absorption spectrum. A PT-OCT system was developed to detect this pH-induced aggregation by combining an OCT light source and a laser with 660 nm in wavelength for photothermal excitation. Optical detection of pH-induced aggregation was tested with solution samples at two different pH conditions. An increase in optical path length (OPL ...
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  Mentions: Ki Hean Kim Yonsei University Chulmin Joo
3. In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis
  
  Explore Landes Bioscience Home Oct 23 2013 Oncology
  
  Identification of the early microscopic changes associated with ovarian cancer may lead to development of a diagnostic test for high-risk women. In this study we use optical coherence tomography (OCT) and multiphoton microscopy (MPM) (collecting both two photon excited fluorescence [TPEF] and second harmonic generation [SHG]) to image mouse ovaries in vivo at multiple time points. We demonstrate the feasibility of imaging mouse ovaries in vivo during a long-term survival study and identify microscopic changes associated with early tumor development. These changes include alterations in tissue microstructure, as seen by OCT, alterations in cellular fluorescence and morphology, as seen by ...
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  Mentions: Jennifer K. Barton University of Arizona Urs Utzinger
4. Choroidal Melanocytosis Evaluation with Enhanced Depth Imaging Optical Coherence Tomography
  
  Explore Ophthalmology Oct 16 2013 Oncology , Ophthalmology
  
  Objective To assess eyes with unilateral choroidal melanocytosis using enhanced depth imaging (EDI) optical coherence tomography (OCT). Design Retrospective, observational case series. Participants Fifteen patients with unilateral choroidal melanocytosis. Methods Each patient was evaluated with EDI-OCT, and comparison was made of involved versus uninvolved foveal retinal and choroidal layers. Main Outcome Measures Enhanced depth imaging OCT features of choroidal melanocytosis. Results The mean patient age was 28 years (median, 23 years; range, 5–76 years). There were 9 male and 6 female patients. Best-corrected visual acuity ranged from 20/20 to 20/30. All patients had subfoveal involvement with choroidal ...
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  Mentions: Thomas Jefferson University Jerry A. Shields University of Milan
5. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells
  
  Explore SPIE | Journal Oct 12 2013 Oncology
  
  Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with AF imaging to characterize the AF attenuation due to the epithelium. We present imaging results from three vital tissue models, each consisting of a three-dimensional tissue culture grown from one ...
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  Mentions: British Columbia Cancer Agency Stephen Lam
6. Controversial Data Show RF Ablation Beneficial for Low-Grade in Barrett's
  
  Explore General Surgery News Oct 8 2013 Gastroenterology , Oncology
  
  Radiofrequency ablation in Barrett’s esophagus patients with low-grade dysplasia provides significant protection against progression to high-grade dysplasia or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of radiofrequency ablation (RFA) relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said senior author of the study, Jacques J. Bergman, MD, PhD ...
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  Mentions: Boston Scientific University of North Carolina Olympus
7. Vascular Response to Brachytherapy Using Functional OCT
  
  Explore ClinicalTrials.gov Sep 30 2013 Oncology , Ophthalmology , Clinical Trials
  
  The purpose of this study is to learn how blood flows to tumors in patients treated with I-125 plaque brachytherapy for uveal melanoma. Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening cancer, and even eye-sparing therapy with radiation treatment often leads to significant loss of vision. Major challenges to providing care to patients with uveal melanoma include the inability to accurately predict long-term vision in an eye treated with radiation, due to a poor understanding of the nature of radiation retinopathy and optic neuropathy. Optical coherence tomography (OCT) is a commonly used ophthalmic imaging modality that ...
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  Mentions: David Huang Oregon Health & Science University
8. Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)
  
  Explore arizona.openrepository.com Sep 24 2013 Gastroenterology , Oncology , Student Theses
  
  Optical coherence tomography (OCT) is an imaging method that is considered the optical analog to ultrasound, using the technique of optical interferometry to construct two-dimensional depth-resolved images of tissue microstructure. With a resolution on the order of 10 μm and a penetration depth of 1-2 mm in highly scattering tissue, fiber optics-coupled OCT is an ideal modality for the inspection of the mouse colon with its miniaturization capabilities. In the present study, the complementary modalities laser-induced fluorescence (LIF), which offers information on the biochemical makeup of the tissue, and surface magnifying chromoendoscopy, which offers high contrast surface visualization, are combined ...
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  Mentions: University of Arizona
9. Uncovering Cancer’s Inner Workings by Capturing Live Images of Growing Tumors
  
  Explore Optical Coherence Tomography News Sep 17 2013 Oncology
  
  Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease. Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics ( FiO ), The Optical Society’s ( OSA ) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and ...
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  Mentions: Massachusetts General Hospital Harvard University
10. University of Illinois at Urbana-Champaign Receives NIH Grant for Interaoperative OCT for Determining Lymph Node Status and Staging Cancer
  
  Explore Optical Coherence Tomography News Sep 11 2013 Oncology , Funding
  
  The University of Illinois at Urbana-Champaign Received a 2013 NIH Grant for $559,530 for Interaoperative OCT for Determining Lymph Node Status and Staging Cancer. The principal investigator is Stephen Boppart. The program began in 2010 and ends in 2014. Below is a summary of the proposed work. The surgical treatment of solid tumors frequently involves the resection and post-operative histopathological assessment of sentinel and loco-regional lymph nodes to determine the extent to which the cancer may have spread. This information is also used to stage the disease. The stage of the disease determines the prognosis and dictates treatment strategies ...
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  Mentions: National Institutes of Health Stephen A. Boppart University of Illinois at Urbana-Champaign
11. Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening
  
  Explore ScienceDirect Sep 10 2013 Oncology
  
  In vitro three-dimensional models of cancer have the ability to recapitulate many features of tumors found in vivo , including cell–cell and cell–matrix interactions, microenvironments that become hypoxic and acidic, and other barriers to effective therapy. These model tumors can be large, highly complex, heterogeneous, and undergo time-dependent growth and treatment response processes that are difficult to track and quantify using standard imaging tools. Optical coherence tomography is an optical ranging technique that is ideally suited for visualizing, monitoring, and quantifying the growth and treatment response dynamics occurring in these informative model systems. By optimizing both optical coherence tomography ...
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  Mentions: Massachusetts General Hospital Harvard University
12. SKINTELL from Agfa HealthCare in the picture at the International Summer Academy (ISA) in Munich
  
  Explore Agfa HealthCare — Aug 13 2013 Dermatology , Oncology , Other Business News
  
  Thanks to Dr. Tanja Maier from the Ludwig Maximilian University (LMU) in Munich a dedicated high-quality workshop took place around Agfa HealthCare’s me first technology, called High-Definition Optical Coherence Tomography (HD-OCT), The lecture from Dr. Maier was focused on non-melanoma skin cancers. A SKINTELL demonstration was given and all kinds of images from various skin diseases were discussed. The attendees took the opportunity to use this non-invasive technology and to take images themselves. Our booth received great interest and in this regard many demonstrations were given to dermatologists and young, upcoming dermatologists. During this congress that took place from ...
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  Mentions: AGFA Healthcare AGFA SKINTELL
13. University of Arizona Receives NIH Grant for Dual Modality System for Imaging Colon Cancer in Mice
  
  Explore Optical Coherence Tomography News Aug 6 2013 Gastroenterology , Oncology , Funding
  
  University of Arizona Received a 2013 NIH grant for $285,247 for Dual Modality System for Imaging Colon Cancer in Mice. The principal investigator was Jennifer Barton. The program began in 2004 and ends in 2014. Below is a summary of the work. Mouse models of colon cancer are a critical experimental tool for determining the role of specific genes in carcinogenesis, studying tumor initiation and progression, and testing potential chemopreventive and therapeutic compounds. Typically, mouse study outcomes are determined by sacrifice and colon tissue harvesting for procedures such as tumor count, immunohistochemistry, and various assays. Since each animal can ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
14. UC Irvine Receives NIH Grant for A Low-Cost Simple Oral Cancer Screening Device For Low-Resource Settings
  
  Explore Optical Coherence Tomography News Jul 2 2013 Oncology , Otolaryngology
  
  University of California at Irvine Received a 2013 NIH Grant for $108,857 for A Low-Cost Simple Oral Cancer Screening Device For Low-Resource Settings. The principle Investigator is Petra Wilder-Smith. The program began in 2012 and ends in 2014. Below is a summary of the proposed work. Our long-term goal is to develop an inexpensive, simple, portable means of screening for oral cancer in the field by basic level healthcare workers in low-resource environments. Screening will identify whether a person needs to travel to a center with higher levels of expertise in oral cancer for further tests and potential cancer ...
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  Mentions: National Institutes of Health UC Irvine Petra E. Wilder-Smith
15. Optical detection of cancer and precancerous lesions of the upper aerodigestive tract: methods for assessment of vertical extensions
  
  Explore Conference Proceedings Jun 30 2013 Oncology , Otolaryngology
  
  Introduction: Endoscopic imaging can be used in the assessment of cancer and precancerous lesions of the upper aerodigestive tract. The objective of this presentation is to describe vertical imaging methods. Methods: The working principle and technique of optical coherence tomography (OCT) as well as endosonography (EUS) are briefly illustrated. Results: The main indications, normal and pathologic findings of each method, frequent pitfalls, and clinical results up to now are presented in detail. Conclusions: Endosonography helps in determining the exact extension of advanced carcinomas beyond 3 mm, while OCT, due to its better resolution, is superior in the assessment of precancerous ...
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16. Early Lung Cancer: Methods for Detection
  
  Explore Clinics In Chest Medicine Jun 20 2013 Oncology , Pulmonology
  
  Early detection and surgical resection are essential for the treatment of lung cancer. It would be ideal to be able to detect and treat preinvasive bronchial lesions, defined as dysplasia and carcinoma in situ before progressing to invasive cancer. Advanced airway-assessment techniques have opened an avenue for early detection and surveillance of endobronchial malignancy. This article reviews currently available advanced imaging techniques for early detection of lung cancer, including autofluorescence bronchoscopy, narrow-band imaging, high-magnification bronchovideoscopy, endobronchial ultrasonography, and optical coherence tomography. Also discussed are the more recently developed endocytoscopy system and confocal fluorescence microendoscopy, currently used only for research purposes.
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  Mentions: Ontario Cancer Institute University of Toronto
17. University of Illinois Urbana-Champaign Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins
  
  Explore Optical Coherence Tomography News Jun 18 2013 Oncology , Funding
  
  UIUC Received a 2013 NIH Grant for $362,533 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investigator is Stephen Boppart. The program started in 2012 and ends in 2017. Below is a summary of the proposed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to verify complete resection of ...
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  Mentions: National Institutes of Health Stephen A. Boppart University of Illinois at Urbana-Champaign
18. Examination of Diagnostic Features in Multiphoton Microscopy and Optical Coherence Tomography Images of Ovarian Tumorigenesis in a Mouse Model (Thesis)
  
  Explore arizona.openrepository.com Jun 11 2013 Gynecology , Oncology , Student Theses
  
  Ovarian cancer is a deadly disease owing to the non-specific symptoms and suspected rapid progression, leading to frequent late stage detection and poor prognosis. Medical imaging methods such as CT, MRI and ultrasound as well as serum testing for cancer markers have had extremely poor performance for early disease detection. Due to the poor performance of available screening methods, and the impracticality and ineffectiveness of taking tissue biopsies from the ovary, women at high risk for developing ovarian cancer are often advised to undergo prophylactic salpingo-oophorectomy. This surgery results in many side effects and is most often unnecessary since only ...
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  Mentions: University of Arizona
19. Michelson Diagnostics wins Regulatory Approval for VivoSight OCT Scanner in Australia
  
  Explore Optical Coherence Tomography News Jun 10 2013 Dermatology , Oncology , Other Business News
  
  Michelson Diagnostics Press release: Michelson Diagnostics the UK based medical device company has been given regulatory approval by the Therapeutics Goods Administration (TGA) in Australia to start selling its market leading VivoSight OCT Scanner. Australia has the highest incidence of skin cancer in the world and the number of people needing treatment continues to grow. The Australian Institute of Health and Welfare and Cancer Australia estimates there were 430,000 new cases of Non-Melanoma Skin Cancer diagnosed in 2008. This is approximately four-fold higher than the number of new cases diagnosed in the UK. In a recent position statement, the ...
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  Mentions: Michelson Diagnostics Jon Holmes Michelson Diagnostics Vivosight
20. High-Definition Optical Coherence Tomography (HD-OCT)
  
  Explore Agfa HealthCare — May 17 2013 Dermatology , Oncology
  
  Munich Germany, Priv. Doz. Dr. Gerald Messer (Munich, Germany) makes use of an AGFA SKINTELL unit for test purpose. He is quite impressed about the new technologies performance, especially in diagnosis of non-melanoma skin cancer. A first test is so promising that a second closer look will be done with associated clinics in June. “The new High-Definition Optical Coherence Tomography (HD-OCT) technology will give the opportunity to diagnose actinic keratosis and basal cell carcinoma without intervention in an early stage where non-invasive therapies are promising”. Dr. Messer reported also some success from the DDG (Deutsche Dermatologische Gesellschaft) Congress that was ...
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  Mentions: AGFA Healthcare AGFA SKINTELL
21. Subsquamous intestinal metaplasia after ablation of Barrett's esophagus: frequency and importance
  
  Explore LWW Online May 16 2013 Gastroenterology , Oncology
  
  Purpose of review: This article reviews reports on the prevalence of subsquamous intestinal metaplasia (SSIM) in patients with Barrett's esophagus, and the implications of SSIM in the neoplastic progression of Barrett's esophagus to esophageal adenocarcinoma. Recent findings: Endoscopic eradication therapy for dysplastic Barrett's esophagus has become an encouraging alternative to esophagectomy or continued endoscopic surveillance. However, the presence of SSIM before and after ablation is concerning because this tissue may have potential for malignant progression, is not visible by conventional endoscopy, and may evade detection by random esophageal biopsy sampling methods. Advances in endoscopic high-resolution three-dimensional optical ...
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  Mentions: Harvard University Hiroshi Mashimo
22. University of Arizona Receives NIH Grant for Diagnosis of Ovarian Cancer by Confocal Microendoscopy.
  
  Explore Optical Coherence Tomography News May 11 2013 Gynecology , Oncology , Funding
  
  University of Arizona Received a 2013 NIH Grant for $65,063 for Diagnosis of Ovarian Cancer by Confocal Microendoscopy. The principal investigator is Arthur Gmitro. The program started in 2005 and ends in 2014. Below is a summary of the proposed work. The objective of this research is to further develop and clinically validate a real-time multispectral confocal microendoscope for in vivo diagnosis of ovarian cancer. The confocal microendoscope is a new type of instrument for visualizing tissue at the cellular level and has shown great promise for performing optical biopsy. Confocal microendoscopy has the potential to provide a physician ...
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  Mentions: National Institutes of Health University of Arizona
23. Imaging of non-tumorous and tumorous human brain tissues with full-field optical coherence tomography
  
  Explore ScienceDirect May 9 2013 Neurology , Oncology
  
  A prospective study was performed on neurosurgical samples from 18 patients to evaluate the use of full-field optical coherence tomography (FF-OCT) in brain tumor diagnosis. FF-OCT captures en face slices of tissue samples at 1 μm resolution in 3D to a penetration depth of around 200 μm. A 1 cm 2 specimen is scanned at a single depth and processed in about 5 min. This rapid imaging process is non-invasive and requires neither contrast agent injection nor tissue preparation, which makes it particularly well suited to medical imaging applications. Temporal chronic epileptic parenchyma and brain tumors such as meningiomas, low-grade ...
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  Mentions: Claude Boccara Fabrice Harms LLTech
24. In vitro study of the effects of ultrasound-mediated glycerol on optical attenuation of human normaland cancerous esophageal tissues with optical coherence tomography
  
  Explore IOPscience May 8 2013 Gastroenterology , Oncology
  
  Previous studies from our group have demonstrated that glucose solution can induce optical clearing enhancement of esophageal tissues with optical coherence tomography (OCT). The aims of this study were to evaluate the optical clearing effects of ultrasound-mediated optical clearing agents (OCAs) and to find more effective methods to distinguish human normal esophageal tissues (NE) and cancerous esophageal tissues (CE). Here we used the OCT technique to investigate the optical attenuation of NE and CE in vitro after treatment with 30% glycerol alone and glycerol combined with ultrasound, respectively. Experimental results showed that the averaged attenuation coefficient of CE was significantly ...
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  Mentions: Fujian Normal University South China Normal University
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