1. Articles in category: Oncology

    1-24 of 425 1 2 3 4 ... 16 17 18 »
    1. Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography

      Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography

      Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for regular follow-up studies. Using information obtained with SS-OCT, we performed intensity-modulated radiotherapy (IMRT) for a patient with choroidal metastasis from breast cancer with more accuracy than had been previously possible. We made replanning adaptive radiotherapy (ART) three times based on the rapid tumor shrinkage detected by weekly assessments with SS-OCT. Accordingly, the planning target volume (PTV) decreased from 1.6 cm 3 to 0.61 cm 3 (38%), with 0.95 cm 3 (59%) and ...

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      Mentions: Osaka University
    2. Optical Coherence Tomography in Staging Patients With Upper Tract Urothelial Cancer

      Optical Coherence Tomography in Staging Patients With Upper Tract Urothelial Cancer

      This clinical trial studies how well optical coherence tomography works in staging patients with upper-tract urothelial carcinomas. Staging describes the severity of a person's cancer based on the size and/or extent (reach) of the original (primary) tumor and whether or not cancer has spread in the body. It also helps the doctor plan the appropriate treatment. Optical coherence tomography is a procedure that uses infrared light waves to give three-dimensional pictures of structures inside tissues and organs. The pictures are made by a computer linked to the light source. Optical coherence tomography may be effective in staging patients ...

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    3. Photoacoustics Technology Holds Promise For Advances In Cancer Research

      Photoacoustics Technology Holds Promise For Advances In Cancer Research

      Photoacoustic and thermoacoustic imaging is an emerging hybrid biomedical imaging technology based on the photoacoustic effect when non-ionizing laser pulses are delivered into biological tissues. In recognition of advances in the photoacoustics (AKA optoacoustics) and thermoacoustics field, last fall, Amsterdam-based scientific, technical and medical information products and services publisher Elsevier launched of the new open access journal eponymously called “Photoacoustics .” The goal of Photoacoustics is to publish original research and review contributions within this fast-growing scientific field, in which optically and electromagnetically excited acoustical and thermal phenomena are exploited for visualization and characterization of a variety of materials and biological ...

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    4. Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

      Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

      We describe a combination of fabrication techniques and a general process to construct a three-dimensional (3-D) phantom that mimics the size, macroscale structure, microscale surface topology, subsurface microstructure, optical properties, and functional characteristics of a cancerous bladder. The phantom also includes features that are recognizable in white light (i.e., the visual appearance of blood vessels), making it suitable to emulate the bladder for emerging white light + optical coherence tomography (OCT) cystoscopies and other endoscopic procedures of large, irregularly shaped organs. The fabrication process has broad applicability and can be generalized to OCT phantoms for other tissue types or phantoms ...

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    5. Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination

      Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination

      Optical spectroscopy and imaging methods have proved to have potential to discriminate between normal and abnormal tissue types through minimally invasive procedures. Raman spectroscopy and Optical Coherence Tomography (OCT) provides chemical and morphological information of tissues respectively, which are complementary to each other. When used individually they might not be able to obtain high enough sensitivity and specificity that is clinically relevant. In this study we combined Raman spectroscopy information with information obtained from OCT to enhance the sensitivity and specificity in discriminating between Colonic Adenocarcinoma from Normal Colon. OCT being an imaging technique, the information from this technique is ...

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    6. Optical coherence tomography imaging of ocular and periocular tumours

      Optical coherence tomography imaging of ocular and periocular tumours

      Optical coherence tomography (OCT) has become pivotal in the practice of ophthalmology. Similar to other ophthalmic subspecialties, ophthalmic oncology has also incorporated OCT into practice. Anterior segment OCT (AS-OCT), ultra-high resolution OCT (UHR-OCT), spectral domain OCT (SD-OCT) and enhanced depth imaging OCT (EDI-OCT), have all been described to be helpful in the diagnosis, treatment planning and monitoring response of ocular and periocular tumours. Herein we discuss the role of OCT including the advantages and limitations of its use in the setting of common intraocular and adnexal tumours.

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      Mentions: Cleveland Clinic
    7. Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key

      Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key

      Radiofrequency ablation (RFA) in Barrett’s esophagus (BE) patients with low-grade dysplasia (LGD) provides significant protection against progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of RFA relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said the senior author of the study, Jacques J ...

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    8. Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.

      Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.

      Pre-operative X-ray mammography and intraoperative X-ray specimen radiography are routinely used to identify breast cancer pathology. Recent advances in optical coherence tomography (OCT) have enabled its use for the intraoperative assessment of surgical margins during breast cancer surgery. While each modality offers distinct contrast of normal and pathological features, there is an essential need to correlate image -based features between the two modalities to take advantage of the diagnostic capabilities of each technique. We compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-time intraoperative OCT imaging . X-ray ...

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    9. Fast diagnostic cancer imaging technique displayed at Photonics West 2014

      Fast diagnostic cancer imaging technique displayed at Photonics West 2014

      One of the numerous technologies and applications being highlighted at Photonics West 2014 was a non-invasive optical imaging system used to quickly obtain images at the cellular level to assist in diagnoses and biopsies. CAReIOCA began in 2012 as a collaborative project funded by the European Commission’s Seventh Framework Programme. The project saw the development of an imaging system with the purpose of providing a medical tool for better localization and analysis of cancer biopsies in the operating room in order to "reduce failure and reoperation rates in pre-operative diagnosis." CAReIOCA’s technical partners, LLTech , CMOSIS, and Adimec collaborated ...

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      Mentions: LLTech
    10. Intraoperative assessment of margins in breast conserving therapy: A systematic review

      Intraoperative assessment of margins in breast conserving therapy: A systematic review

      Approximately one quarter of patients undergoing breast conserving therapy for breast cancer will require a second operation to achieve adequate clearance of the margins. A number of techniques to assess margins intraoperatively have been reported. This systematic review examines current intraoperative methods for assessing margin status. The final pathology status, statistical measures including accuracy of tumour margin assessment, average time impact on the procedure and second operation rate, were used as criteria for comparison between studies. Although pathological methods, such as frozen section and imprint cytology performed well, they added on average 20–30 min to operation times. An ultrasound ...

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    11. Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Angle-resolved low coherence interferometry (a/LCI) directly measures diagnostically relevant sub-cellular features in epithelial tissues up to 500 μm below the surface. Unlike optical coherence tomography (OCT), which requires image interpretation, a/LCI performs analysis of tissue and delivers to the physician direct confirmation of precancerous disease. Because it offers the greatest opportunity for successful intervention and therapy, a key weapon in the fight against cancer is early detection. If disease can be found in the precancerous stage, before abnormal cells have had the chance to spread throughout the body, the efficacy of treatment can be quite high. The clinical ...

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    12. Imaging of noncarious cervical lesions by means of a fast swept source optical coherence tomography system

      Imaging of noncarious cervical lesions by means of a fast swept source optical coherence tomography system

      Non-carious cervical lesions (NCCL) are defined as the loss of tooth substance at the cemento-enamel junction and are caused by abrasion, erosion and/or occlusal overload. In this paper we proved that our fast swept source OCT system is a valuable tool to track the evolution of NCCL lesions in time. On several extracted bicuspids, four levels of NCCL were artificially created. After every level of induced lesion, OCT scanning was performed. B scans were acquired and 3D reconstructions were generated. The swept source OCT instrument used in this study has a central wavelength of 1050 nm, a sweeping range ...

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    13. Imaging of oral pathological tissue using optical coherence tomography

      Imaging of oral pathological tissue using optical coherence tomography

      Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images ...

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    14. Surgical margins in breast conservation

      Surgical margins in breast conservation

      Breast cancer is the most common tumor affecting women worldwide. Breast-conserving therapy (BCT) followed by irradiation nowadays is the treatment of choice for early-stage disease; there is no difference in long-term survival between mastectomy and BCT combined with external radiotherapy. A positive margin is associated with increased risk of local recurrences after BCT for invasive breast cancer and ductal carcinoma in situ. The exact definition of an adequate surgical margin after breast cancer resection has long been debated among physicians and represents an area of considerable variation in clinical practice. There is a lack of standardization in the pathology methods ...

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    15. Full field optical coherence tomography of prostate biopsies: A step towards pre-histological diagnosis?

      Full field optical coherence tomography of prostate biopsies: A step towards pre-histological diagnosis?

      Objectives To evaluate the value of full field optical coherence tomography (FFOCT) for cancer detection on prostate biopsies Patients and methods Eight consecutive patients who underwent prostate biopsies for an elevated PSA or suspicious DRE findings were included in the study. For each patient, one to three biopsy cores were imaged with FFOCT immediately after sampling. Images obtained were analyzed by a pathologist blinded to the pathological results, and classified into three categories: non-cancerous tissue, suspicion of malignancy and prostate carcinoma. A pathological correlation analysis was further performed. Results Sixteen biopsy cores were analyzed. The median FFOCT procedure time was ...

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    16. Picturing Cervical Cancer

      Picturing Cervical Cancer

      The Pap smear has been used to test women for cervical cancer since its invention in 1928. With a simple swipe and smear, doctors have been able to use microscopic observation to detect cancerous activity. Because cervical cancer is one of the most preventable forms of cancer, the Pap smear revolutionized how we deal with the disease. Yet, worldwide, 275 000 women ( 1 ) still die from cervical cancer each year. That's because although the Pap is an efficient test, it requires elements such as facilities, follow-up visits, and trained cytology technicians, making it difficult to use in low- to ...

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    17. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Optical Coherence Tomography (OCT) has proven a powerful tool for ophthalmologists to make clinical decisions for a wide range of blinding diseases and the there are now ~20 million ophthalmic OCT patient scans per year. Significant progress is also being made in intravascular imaging where OCT is emerging as a tool for both clinical decision making and the understanding of cardiovascular disease and development of new therapeutic tools. OCT also has the potential to impact the understanding, diagnosis, and treatment of some forms of cancer. There are many leading research groups around the world that are making excellent progress in ...

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    18. Detection of pH-induced aggregation of "smart" gold nanoparticles with photothermal optical coherence tomography

      Detection of pH-induced aggregation of "smart" gold nanoparticles with photothermal optical coherence tomography

      We report the feasibility of a novel contrast agent, namely “smart” gold nanoparticles (AuNPs), in the detection of cancer cells with photothermal optical coherence tomography (PT-OCT). “Smart” AuNPs form aggregation in low pH condition, which is typical for cancer cells, and this aggregation results in a shift of their absorption spectrum. A PT-OCT system was developed to detect this pH-induced aggregation by combining an OCT light source and a laser with 660 nm in wavelength for photothermal excitation. Optical detection of pH-induced aggregation was tested with solution samples at two different pH conditions. An increase in optical path length (OPL ...

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    19. In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis

      In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis

      Identification of the early microscopic changes associated with ovarian cancer may lead to development of a diagnostic test for high-risk women. In this study we use optical coherence tomography (OCT) and multiphoton microscopy (MPM) (collecting both two photon excited fluorescence [TPEF] and second harmonic generation [SHG]) to image mouse ovaries in vivo at multiple time points. We demonstrate the feasibility of imaging mouse ovaries in vivo during a long-term survival study and identify microscopic changes associated with early tumor development. These changes include alterations in tissue microstructure, as seen by OCT, alterations in cellular fluorescence and morphology, as seen by ...

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    20. Choroidal Melanocytosis Evaluation with Enhanced Depth Imaging Optical Coherence Tomography

      Choroidal Melanocytosis Evaluation with Enhanced Depth Imaging Optical Coherence Tomography

      Objective To assess eyes with unilateral choroidal melanocytosis using enhanced depth imaging (EDI) optical coherence tomography (OCT). Design Retrospective, observational case series. Participants Fifteen patients with unilateral choroidal melanocytosis. Methods Each patient was evaluated with EDI-OCT, and comparison was made of involved versus uninvolved foveal retinal and choroidal layers. Main Outcome Measures Enhanced depth imaging OCT features of choroidal melanocytosis. Results The mean patient age was 28 years (median, 23 years; range, 5–76 years). There were 9 male and 6 female patients. Best-corrected visual acuity ranged from 20/20 to 20/30. All patients had subfoveal involvement with choroidal ...

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    21. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

      Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

      Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with AF imaging to characterize the AF attenuation due to the epithelium. We present imaging results from three vital tissue models, each consisting of a three-dimensional tissue culture grown from one ...

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    22. Vascular Response to Brachytherapy Using Functional OCT

      Vascular Response to Brachytherapy Using Functional OCT

      The purpose of this study is to learn how blood flows to tumors in patients treated with I-125 plaque brachytherapy for uveal melanoma. Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening cancer, and even eye-sparing therapy with radiation treatment often leads to significant loss of vision. Major challenges to providing care to patients with uveal melanoma include the inability to accurately predict long-term vision in an eye treated with radiation, due to a poor understanding of the nature of radiation retinopathy and optic neuropathy. Optical coherence tomography (OCT) is a commonly used ophthalmic imaging modality that ...

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    23. Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)

      Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)

      Optical coherence tomography (OCT) is an imaging method that is considered the optical analog to ultrasound, using the technique of optical interferometry to construct two-dimensional depth-resolved images of tissue microstructure. With a resolution on the order of 10 μm and a penetration depth of 1-2 mm in highly scattering tissue, fiber optics-coupled OCT is an ideal modality for the inspection of the mouse colon with its miniaturization capabilities. In the present study, the complementary modalities laser-induced fluorescence (LIF), which offers information on the biochemical makeup of the tissue, and surface magnifying chromoendoscopy, which offers high contrast surface visualization, are combined ...

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    24. Uncovering Cancer’s Inner Workings by Capturing Live Images of Growing Tumors

      Uncovering Cancer’s Inner Workings by Capturing Live Images of Growing Tumors

      Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease. Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics ( FiO ), The Optical Society’s ( OSA ) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and ...

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    1-24 of 425 1 2 3 4 ... 16 17 18 »
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