1. Articles in category: Oncology

    1-24 of 514 1 2 3 4 ... 20 21 22 »
    1. EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential

      EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential

      Cancer diagnosis relies on the long and complex histology process. During surgery, there is currently no real- time guidance at the histology level, leading to up to 40% of reoperations . Along the cancer care workflow , in particular for tumor biopsy and excision, current existing preoperative and intraoperative imaging techniques fail to perform a reliable in situ diagnosis. Moreover, the complete pathological diagnosis, often based on histology slides preparation, is usually only available after a few days. For these reasons a significant number of patients need to undergo secondary biopsy or surgery. The CAReIOCA project combined the latest advances in CMOS ...

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    2. An implant to catch metastatic cancer cells before they grow into tumors

      An implant to catch metastatic cancer cells before they grow into tumors

      There could be a way around this, though: a special imaging method under development at Northwestern University called Inverse Spectroscopic Optical Coherence Tomography (ISOCT). ISOCT detects molecular-level differences in the way cells in the body scatter light. And when we scan our implant with ISOCT, the light scatter pattern looks different when it's full of normal cells than when cancer cells are present. In fact, the difference is apparent when even as few as 15 out of the hundreds of thousands of cells in the implant are cancer cells. There's a catch – ISOCT cannot penetrate deep into tissue ...

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    3. Massachusetts General Hospital Receives NIH Grant for Octology: Histology using Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Octology: Histology using Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2016 NIH Grant for $253,600 for Octology: Histology using Optical Coherence Tomography. The principal investigator is Burce Fischl. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. While histology remains the gold standard for assessing human neuroanatomy, the procedures for sectioning and hand mounting tissue for microscopic imaging are not substantially different than they were 100 years ago. These steps introduce irremediable distortions into the tissue sections making it difficult or impossible to align sections with suffiient accuracy to create 3D histological volumes at the micron ...

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    4. Ultrathin lensed fiber-optic probe for optical coherence tomography

      Ultrathin lensed fiber-optic probe for optical coherence tomography

      We investigated and validated a novel method to develop ultrathin lensed fiber-optic (LFO) probes for optical coherence tomography (OCT) imaging. We made the LFO probe by attaching a segment of no core fiber (NCF) to the distal end of a single mode fiber (SMF) and generating a curved surface at the tip of the NCF using the electric arc of a fusion splicer. The novel fabrication approach enabled us to control the length of the NCF and the radius of the fiber lens independently. By strategically choosing these two parameters, the LFO probe could achieve a broad range of working ...

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    5. OCT variant looks good for vascular imaging

      OCT variant looks good for vascular imaging

      Researchers in New York have shown that a variation of optical coherence tomography (OCT) is able to tell melanomas apart from other skin lesions, by imaging the patterns of blood vessels that surround them. The small, early-stage study suggests that speckle-variance (sv) OCT could become a useful clinical tool for quickly identifying the most dangerous form of skin cancer, although a larger clinical trial of the technique will be needed to prove its utility first. Writing in the open access journal Dermatology Online , Orit Markowitz and colleagues looked at two pairs of malignant and benign lesions that are typically difficult ...

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    6. Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma – a prospective, consecutive, cohort study of 168 cases

      Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma – a prospective, consecutive, cohort study of 168 cases

      Non-melanoma skin cancers (NMSCs), consisting overwhelmingly of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is the most prevalent malignancy in Western populations with large populations of Caucasians. BCC forms the majority of NMSC and its incidence continues to rise in many countries; Australia has the highest incidence rate worldwide at >1000/100,000 person-years.(1-3) Although BCC is usually not life-threatening, it represents a major public health burden. In Australia, the number of treatment episodes for NMSC is more than five times that of all other cancers combined, making them the most expensive cancers to treat.(4)

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    7. Orbital Metastasis From Breast Cancer without Significant Changes in CT Scan and MRI

      Orbital Metastasis From Breast Cancer without Significant Changes in CT Scan and MRI

      Dear Editor , Orbital metastasis infrequently occurs in breast cancer ( 1 ); however breast cancer is the most common cause of orbital metastasis ( 2 - 5 ), followed by lung, prostate, gastrointestinal tract, and skin (melanoma) cancers ( 6 , 7 ). Definite diagnosis of an orbital lesion includes an orbital biopsy (either FNA or open biopsy). However, in patients with known metastatic cancer, CT scan or MRI of the orbits can frequently show the presence of a mass, which often involves the orbital fat or extraocular muscles ( 4 , 5 ). On the other hand, these techniques may not completely reflect the metastases. Optical coherence tomography (OCT) is ...

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    8. Optical coherence tomography in oral cancer: A transpiring domain

      Optical coherence tomography in oral cancer: A transpiring domain

      Identification of oral cancer at an early curable stage not only aids in controlling the mortality and morbidity rate but also improves the quality of life of the patient. Indeed, regular monitoring of such life-threatening disease has held an imperative role in cancer diagnostics. Various light-based diagnostics are currently available to the clinician for early diagnosis of oral cancer. Optical coherence tomography (OCT) is one such emerging light-based diagnostic modality that provides noninvasive, real-time images at a depth of 1.5–2 mm and can also be compared to corresponding histopathological sections, hence this procedure can also be referred as ...

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    9. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      It is known that the progression of oral cancer is accompanied by changes in both tissue biochemistry and morphology. A multimodal imaging approach combining functional and structural imaging modalities could therefore provide a more comprehensive prognosis of oral cancer. This idea forms the central theme of the current study, wherein this premise is examined in the context of a multimodal imaging system that combines fluorescence lifetime imaging (FLIM) and optical coherence tomography (OCT). Towards this end, in the first part of the present study, the diagnostic advantage obtained by using both fluorescence intensity and lifetime information is assessed. In the ...

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    10. Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Background— We previously described a strong association between fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection. Angiographic manifestations of coronary FMD aside from dissection were considered rare. However, we observed several coronary FMD angiographic abnormalities with corresponding optical coherence tomography abnormalities. Methods and Results— Baseline demographics and imaging of patients with suspected coronary FMD at Vancouver General Hospital were reviewed. Presence of multifocal (string-of-beads) extracoronary FMD was confirmed by 2 specialists. In these patients, coronary angiographic findings (excluding dissected segments) were reviewed and classified by 2 experienced angiographers for irregular stenosis, that is, stenosis with irregular borders in a focal ...

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      Mentions: Hiram G. Bezerra
    11. Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and ...

      Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and ...

      New Skin Cancer Treatment Without Surgical Biopsy Available at Mount Sinai: Optical Coherence Tomography (OCT) is a non-invasive imaging modality that can visualize skin structure, and has been proven useful in evaluating the degree of sun damage in skin and identifying pre-cancerous lesions. Through the use of non-ablative lasers, Mount Sinai’s Dr. Markowitz, is one of the only experts in the U.S. using the device. She has been able to successfully treat — without cutting — both early and even more advanced non-melanoma skin cancers using OCT technology. According to Dr. Markowitz, non-melanoma skin cancers are not as deadly as ...

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    12. Volumetric analysis of pathologies

      Volumetric analysis of pathologies

      Systems and methods are provided for volumetric analysis of pathologies. A segmentation component is configured to determine, for each of a series of images of a region of interest containing a pathological feature, a set of segmentation boundaries within the image representing a cross-section of the pathological feature. A mesh generation component is configured to link the sets of segmentation boundaries from adjacent images in the series of images to generate a polygonal mesh representing a volumetric reconstruction of the pathological feature. A volumetric measurement component is configured to calculate volumetric parameters from the volumetric reconstruction representing the pathological feature ...

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    13. Method for identifying malignancies in barrett's esophagus using white light endoscopy

      Method for identifying malignancies in barrett's esophagus using white light endoscopy

      A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T.sub.HB and oxygenation SO.sub.2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation ...

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    14. Measuring intracellular motion in cancer cell using optical coherence tomography

      Measuring intracellular motion in cancer cell using optical coherence tomography

      In this study, we demonstrate that OCT speckle decorrelation techniques can be used to probe intracellular motion in cancer cells. Spheroids and cell pellets were used as a model to probe intracellular motion. ZnCl 2 was used to inhibit mitochondrial motion within the cells. The results reveal the changes in intracellular motion during the spheroid growth phase. Moreover, to modify the motion of mitochondria, cell pellet were exposed to ZnCl 2 , and agent known to o impair cellular energy production through inhibition of mitochondrial function. The speckle decorrelation time during the growth phase of spheroids decreased by 35 ms over ...

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    15. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

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    16. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight ® , Callisto ® and Skintell ® . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness ...

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    17. Chicago startup raises $3M for probe to prevent repeat cancer surgeries

      Chicago startup raises $3M for probe to prevent repeat cancer surgeries

      A c hicago-based company has raised $3.1 million to fund a clinical trial for its high-resolution imaging probes for cancer surgeons. Diagnostic Photonics, which launched in 2011 at the University of Illinois at Urbana-Champaign, hopes its technology will prevent multiple surgeries for cancer patients. The company is focusing efforts first on breast cancer because about 25 percent of affected women undergo multiple surgeries after lumpectomy, according to a study conducted by the University of Wisconsin Carbone Cancer Center in Madison. The repeat surgeries are often spurred by the “challenges of where does the cancer stop and normal tissues start ...

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    18. Skin Cancer Biopsied by Optical Scan

      Skin Cancer Biopsied by Optical Scan

      Apollo Medical Optics Inc. (Taipei, Taiwan) aims to revolutionize skin cancer detection without the need for invasive biopsies by using a single-crystal sapphire and yttrium aluminium garnet crystalline fibers—surrounded by glass and a flexible polymer cladding—to look-through the skin and image suspicious skin anomalies non-invasively, instead of taking a skin sample and risk releasing malignant cancer cells into the bloodstream. The current prototype, using single-crystal sapphire at its core, is being integrated into a desktop unit that physicians can use in the office to identify skin cancer in a matter of minutes, determine its size and if small ...

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    19. Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Background and Objectives We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC). Methods A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports. Results The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively ...

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    20. Indo-US experts to develop solar-powered oral cancer detector

      Indo-US experts to develop solar-powered oral cancer detector

      Indian researchers along with US are working on a solar-powered device that could detect oral cancer at an early stage. It will enable faster and accurate diagnostics in rural areas through mobile technology. Designed by the Beckman Laser Institute (BLI), University of California-Irvine (UCI) and the Mazumdar Shaw Cancer Centre (MSCC) in Bengaluru, the compact screening and diagnosing system - slightly larger than a shoe box - has been specially adapted for India, which has one of the highest rates of head and neck cancers in the world and accounts for the highest rate among women. Its light-weight and user-friendly features mean ...

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    21. Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Objective : To determine the diagnostic accuracy of optical coherence tomography for basal cell carcinoma and the proportion of biopsies that could be avoided if optical coherence tomography is used to rule-in surgery. Design : Multicenter, prospective, observational study. Setting : Dermatology clinics. Participants : Consecutive patients with clinically challenging pink lesions suspicious for basal cell carcinoma. Measurements : Clinical, dermoscopic, and optical coherence tomography images were obtained for all subjects. At each stage, the clinician made a diagnosis (pathology + subtype if applicable), and assessed his/her own confidence in the diagnosis. Results : Optical coherence tomography significantly (p<0.01) improved sensitivity and specificity over ...

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    22. ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      Barrett’s esophagus (BE) is among the most common conditions encountered by the gastroenterologist. In this document, the American College of Gastroenterology updates its guidance for the best practices in caring for these patients. These guidelines continue to endorse screening of high-risk patients for BE; however, routine screening is limited to men with reflux symptoms and multiple other risk factors. Acknowledging recent data on the low risk of malignant progression in patients with nondysplastic BE, endoscopic surveillance intervals are attenuated in this population; patients with nondysplastic BE should undergo endoscopic surveillance no more frequently than every 3–5 years. Neither ...

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    23. 'Ultrasound Using Light' May Aid Tumor Removal

      'Ultrasound Using Light' May Aid Tumor Removal

      Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact—and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient's brain showing which areas are and are not cancer. A summary of the research appears in the June 17 issue of Science Translational Medicine . "As a neurosurgeon, I'm in agony when ...

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    24. Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Malignant tumor strongholds and their microscopic spies can’t hide in the thicket of flesh much longer, for surgeons have a new weapon: a device that sheds light on their location. Literally. “Any state of disease will alter the cells and molecules in our body,” said Dr. Stephen Boppart, a professor of bioengineering at the University of Illinois who invented the device. Every molecule scatters light different ways, he said, “leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave ...

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    1-24 of 514 1 2 3 4 ... 20 21 22 »
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