1. Articles in category: Oncology

    1-24 of 452 1 2 3 4 ... 17 18 19 »
    1. Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Background and Objective We utilize a miniature, dual-modality endoscope that combines fluorescence-based surface magnifying chromoendoscopy (SMC) and optical coherence tomography (OCT) to follow the anatomical changes that occur during adenoma development in the mouse colon. Materials and Methods Twenty-five mice were treated with the carcinogen azoxymethane (AOM) to induce tumor development in the distal colon, or were treated with saline as control, and were imaged over six months. OCT detects adenoma number with high sensitivity and specificity and can measure lesion size. In methylene blue-lavaged colons, SMC detects changes in the colonic crypts. SMC images of control mouse colons exhibit ...

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    2. Computed Optical Margin Assessment for Breast Cancer Surgery, Phase I (Part B)

      Computed Optical Margin Assessment for Breast Cancer Surgery, Phase I (Part B)

      This intraoperative study is a prospective study analyzing specimens from fifty subjects. Patients scheduled to undergo breast- conserving surgery will be recruited in accordance with the inclusion and exclusion criteria. The study period per subject is the time it takes to assess the ex vivo breast tissue sample using the study device. Image review will be conducted during surgery and compared to the margin status findings in the post-operative pathology report.

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    3. Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

      Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

      We present first quantitative three-dimensional (3D) data sets recorded using optical coherence elastography (OCE) for the diagnosis and detection of prostate cancer (PCa). 120 transrectal ultrasound guided prostate biopsy specimens from 10 men suspected with prostate cancer were imaged using OCE. 3D quantitative mechanical assessment of biopsy specimens obtained in kilopascals (kPa) at an interval of 40 µm was compared with histopathology. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE in comparison to histopathology. The results show OCE imaging could reliably differentiate between benign prostate tissue, acinar atypical hyperplasia, prostatic intraepithelial neoplasia and malignant PCa. The ...

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    4. Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Since it was first used to evaluate human genitourinary tissue in 1997, OCT has emerged as a promising modality to provide real-time, high-resolution imaging of urologic organs. In the bladder, it has demonstrated a high sensitivity in identifying regions of the bladder suspicious for CIS and between invasive and noninvasive malignancy; it has been studied as an “optical biopsy” both during the initial cystoscopic diagnosis and intraoperatively in bladder-preserving surgery. Several small, ex vivo studies have shown promising results in the ability of OCT to demonstrate histopathologic alterations to renal morphology such as in renal ischemia and malignancy. It may ...

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    5. Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      The current diagnostic standard for grading and staging of non-muscle-invasive bladder cancer (NMIBC) is based on the histopathology obtained during transurethral resection of the bladder tumour (TURBT) or biopsies. Although considered reference standard, this technique has some limitations: First, no real-time intraoperative histological information is obtained on stage and grade. Real-time intraoperative histological information could be helpful when NMIBC is treated by electric coagulation or laser ablation. The urologist has to rely on his/her judgement of stage and grade since no tissue is harvested for histological confirmation. In addition, in many centres, patients with a history of low-grade, non-invasive ...

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    6. The Value of Optical Coherence Tomography in Determining Surgical Margins in Squamous Cell Carcinoma of the Vulva: A Single-Center Prospective Study.

      The Value of Optical Coherence Tomography in Determining Surgical Margins in Squamous Cell Carcinoma of the Vulva: A Single-Center Prospective Study.

      Background: Vulvar squamous cell carcinoma (VSCC) is treated with wide local excision. The challenge is to remove as much skin as necessary to prevent recurrence, but meanwhile preserve genital skin to diminish morbidity. Optical coherence tomography (OCT) is a noninvasive imaging tool that produces cross-sectional images. Optical coherence tomography could be helpful in determining appropriate surgical margins during excision of VSCC. Objective: This study aimed to assess the value of OCT in determining appropriate surgical margins in patients operated for VSCC. We hypothesize that benign tissue will differ qualitatively (presence of clear epidermal layers) and quantitatively (epidermal layer thickness and ...

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    7. Endoscopic Eradication Therapy for Barrett's Esophagus

      Endoscopic Eradication Therapy for Barrett's Esophagus

      B arrett’s esophagus (BE) is the precursor lesion to esophageal adenocarcinoma, which in an invasive stage causes significant morbidity and mortality. Surgery was the mainstay of treatment for patients with high-grade dysplasia (HGD) and adenocarcinoma associated with BE. However, surgery in itself carries substantial morbidity. There has been tremendous progress in the minimally invasive treatment of BE in the past decade. The premise to be aggressive in treating dysplastic BE and early-stage adenocarcinoma is to prevent progression to an advanced-stage cancer. Most interventional endoscopists are comfortable treating dysplasia and intramucosal esophageal cancer, although recently there have been emerging data ...

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    8. Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment

      Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment

      Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility ...

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    9. Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      We report an automated classifier to detect the presence of basal cell carcinoma in images of mouse skin tissue samples acquired by polarization-sensitive optical coherence tomography (PS-OCT). The sensitivity and specificity of the classifier based on combined information of the scattering intensity and birefringence properties of the samples are significantly higher than when intensity or birefringence information are used alone. The combined information offers a sensitivity of 94.4% and specificity of 92.5%, compared to 78.2% and 82.2% for intensity-only information and 85.5% and 87.9% for birefringence-only information. These results demonstrate that analysis of the ...

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    10. Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

      Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

      Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility ...

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    11. Importance of Optical Coherence Tomography Grows

      Importance of Optical Coherence Tomography Grows

      Optical coherence tomography (OCT) has become essential to the practice of ophthalmology, offering superior resolution of the retina and some of the adjacent tissues for diagnosis and treatment of eye diseases. New OCT modalities have now been assimilated into ophthalmic oncology to help track the status of ocular and periocular tumors through retinal symptoms. “ Optical coherence tomography imaging of ocular and periocular tumours ,” a review of newer OCT modalities including anterior segment (AS), ultra-high resolution (UHR), spectral domain (SD) and enhanced depth imaging (EDI), describes the current advantages and limitations of their use. Use of OCT shows mixed results The ...

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      Mentions: Cleveland Clinic
    12. Noninvasive Esophageal Cancer Imaging 2014 R&D 100 Winner

      Noninvasive Esophageal Cancer Imaging 2014 R&D 100 Winner

      2014 R&D 100 Winner There are two forms of esophageal cancer: squamous cell carcinoma and adenocarcinoma. Adenocarcinoma is increasing at a rate greater than all other cancers in the U.S. In fact, the American Cancer Society estimated that in 2013, nearly 18,000 new cases of esophageal cancer cases will be diagnosed and more than 15,000 people will die from the condition. Currently, imaging and screening practices of esophageal tissue are time consuming and costly with questionable effectiveness. For the patient, this process is also invasive. However, NinePoint Medical and Farm Design have developed a solution, the ...

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    13. Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Current technique for tumor resection requires biopsy of the tumor region and histological confirmation before the surgeon can be certain that the entire tumor has been resected. This confirmation process is time consuming both for the surgeon and the patient and also requires sacrifice of healthy tissue, motivating the development of novel technologies which can enable real-time detection of tumor-healthy tissue boundary for faster and more efficient surgeries. In this study, the potential of combining structural information from optical coherence tomography (OCT) and molecular information from line-scan Raman microscopy (LSRM) for such an application is presented. The results show a ...

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    14. Strategies for the prevention of oesophageal adenocarcinoma

      Strategies for the prevention of oesophageal adenocarcinoma

      The incidence of oesophageal adenocarcinoma has increased by 500% over the past 30 years [1] . Improved understanding of the mechanisms of neoplastic progression provides an opportunity to reverse this trend. A thorough review of emerging strategies aiming to prevent the formation of oesophageal malignancy is presented. These include dietary modification, chemoprevention, early endoscopic identification and treatment of premalignant disease, and the potential for a non-endoscopic screening test. Oesophageal adenocarcinoma has become a major public health problem in the West and it is essential that clinicians are fully informed of risk reduction strategies so that they can be actively promoted in ...

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    15. New imaging techniques for nonmuscle invasive bladder cancer

      New imaging techniques for nonmuscle invasive bladder cancer

      Purpose of review: Recent advances in imaging techniques provide innovative tools for the detection of bladder cancer. In patients with nonmuscle invasive cancer, there is a need for enhanced visualization of flat growing lesions and multifocal tumors. The aim of new imaging modalities is the improved detection and staging of bladder lesions, as an adjunct to conventional white light endoscopy. Recent findings: Fluorescence cystoscopy with 5-aminolevulinic acid and hexaminolevulinate has been shown to improve the detection of papillary and flat bladder lesions in comparison to conventional white light cystoscopy. Prospective phase III clinical trials have demonstrated advanced diagnostic ability, enhanced ...

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    16. Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy

      Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy

      Ovarian cancer is particularly deadly because it is usually diagnosed after it has metastasized. We have previously identified features of ovarian cancer using optical coherence tomography (OCT) and second-harmonic generation (SHG) microscopy (targeting collagen). OCT provides an image of the ovarian microstructure, while SHG provides a high-resolution map of collagen fiber bundle arrangement. Here, we investigated the diagnostic potential of dual-modality OCT and SHG imaging. We conducted a fully crossed, multireader, multicase study using seven human observers. Each observer classified 44 ex vivo mouse ovaries (16 normal and 28 abnormal) as normal or abnormal from OCT, SHG, and simultaneously viewed ...

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    17. Optical Coherence Tomography for Neurosurgery and Cancer Research (Thesis)

      Optical Coherence Tomography for Neurosurgery and Cancer Research (Thesis)

      Optical Coherence Tomography (OCT) provides non-labeling, real-time and high resolution images, which has the potential to transform the paradigm of surgical guidance and preclinical animal studies. The design and development of OCT devices for neurosurgery guidance and novel imaging algorithms for monitoring anti-cancer therapy have been pursued in this work. A forward-imaging needle-type OCT probe was developed which can fit into minimally invasive tools (I.D. ~ 1mm), detect the at-risk blood vessels, and identify tissue micro-landmarks. This promising guidance tool improves the safety and the accuracy of needle-based procedures, which are currently performed without imaging feedback. Despite the great imaging ...

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    18. Polarization Sensitive Multimodal Imaging for Detecting Breast Cancer

      Polarization Sensitive Multimodal Imaging for Detecting Breast Cancer

      Intra-operative delineation of breast cancer is a significant problem in surgical oncology. A reliable method for demarcation of malignant breast tissue during surgery would reduce the re-excision rate due to positive margins. We present a novel method of identifying breast cancer margins using combined dye-enhanced wide-field fluorescence polarization (FP) imaging for en face cancer margins and polarization sensitive (PS) optical coherence tomography (OCT) for cross-sectional evaluation. Tumor specimens were collected following breast surgery, stained with methylene blue, and imaged. Wide-field FP images were excited at 640 nm and registered between 660 and 750 nm. Standard and PS OCT images were ...

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    19. The handheld smartphone device which could spot cancer

      The handheld smartphone device which could spot cancer

      A £240 ($400) handheld device which can analyse potential tumours is being developed in Tel Aviv. The Mobile OCT device consists of a smartphone to take the images, a lens, some lights and a plastic handle. The images are assessed by the device's operator and are then uploaded for review by a professional. BBC Click's Spencer Kelly reports.

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    20. MobileOCT uses a 3D printed case to turn smartphones into cancer screening devices

      MobileOCT uses a 3D printed case to turn smartphones into cancer screening devices

      There are plenty of nifty smartphone accessories out there today, but how many of them can potentially save lives? MobileOCT is one of the latest startups to raise their hand to that question. The self-described “point-of-care diagnostics company” based in Tel Aviv, Israel, has developed a 3D printed smartphone accessory that leverages a mobile phone’s camera to detect cancer. MobileOCT (pronounced “Mobile Oh-See-Tee” – the “OCT” stands for optical coherence tomography) is starting out by pushing its mobile colposcope, which is a magnifying device used to take images of the vagina or cervix. The company’s first target is cervical ...

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    21. Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)

      Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)

      Ovarian cancer is the fifth most common cancer among women and has the highest mortality rate of all gynecologic cancers. Current clinical imaging modalities are limited by poor sensitivity and specificity. Therefore, there is an urgent need to develop effective tools to detect ovarian cancer. In this dissertation, two imaging modalities, optical coherence tomography (OCT) and photoacoustic imaging have been investigated for ovarian cancer detection and characterization. In the first modality, optical scattering coefficient, phase retardation and phase retardation rate were quantitatively extracted from polarization-sensitive OCT (PS-OCT) images. A highly positive correlation was found between those three parameters and collagen ...

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    22. Full field optical coherence tomography (FFOCT) of prostate biopsies: A step towards pre-histological diagnosis?

      Full field optical coherence tomography (FFOCT) of prostate biopsies: A step towards pre-histological diagnosis?

      Full-field optical coherence tomography (FFOCT) may be a potential additional tool in the strategy of prostate cancer detection. If the technique can be performed safely during transrectal ultrasound (TRUS) biopsy, and without adding significant time to the procedure, the information provided by FFOCT imaging during biopsy would increase the performance level of cancer detection. FFOCT imaging would allow immediate additional sampling in an area suspicious of cancer involvement, thus optimizing its characterization. In cases where there’s an absence of suspicious FFOCT image results in other areas, sampling could be limited to one core, thus decreasing the total number of ...

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    23. OCT Developments Address Skin

      OCT Developments Address Skin

      Recent developments in optical coherence tomography (OCT) address skin cancer diagnosis. MedLumics (Madrid, Spain) has launched a three-year initiative to translate research into new clinical applications—with help from $4.9 million (€3.6 million) in Series A funding from EU joint investors. Called the BiopsyPen Project, the initiative is led by MedLumics and the Medical University of Vienna (Austria), along with European members including VTT Finland (Espoo, Finland), Delft University of Technology in The Netherlands, Exalos (Schlieren, Switzerland), the Polytechnic University of Madrid, and Optocap (Livingston, Scotland). The organizations are working to develop a handheld system for point-of-care diagnosis ...

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    1-24 of 452 1 2 3 4 ... 17 18 19 »
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