Oncology -Optical Coherence Tomography News

Articles in category: Oncology

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1. Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination
  
  Explore Conference Proceedings Mar 8 2014 Gastroenterology , Oncology
  
  Optical spectroscopy and imaging methods have proved to have potential to discriminate between normal and abnormal tissue types through minimally invasive procedures. Raman spectroscopy and Optical Coherence Tomography (OCT) provides chemical and morphological information of tissues respectively, which are complementary to each other. When used individually they might not be able to obtain high enough sensitivity and specificity that is clinically relevant. In this study we combined Raman spectroscopy information with information obtained from OCT to enhance the sensitivity and specificity in discriminating between Colonic Adenocarcinoma from Normal Colon. OCT being an imaging technique, the information from this technique is ...
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  Mentions: Praveen Cheriyan Ashok University of St. Andrews Bavishna B. Praveen
2. Optical coherence tomography imaging of ocular and periocular tumours
  
  Explore BJO Online Mar 5 2014 Oncology , Ophthalmology
  
  Optical coherence tomography (OCT) has become pivotal in the practice of ophthalmology. Similar to other ophthalmic subspecialties, ophthalmic oncology has also incorporated OCT into practice. Anterior segment OCT (AS-OCT), ultra-high resolution OCT (UHR-OCT), spectral domain OCT (SD-OCT) and enhanced depth imaging OCT (EDI-OCT), have all been described to be helpful in the diagnosis, treatment planning and monitoring response of ocular and periocular tumours. Herein we discuss the role of OCT including the advantages and limitations of its use in the setting of common intraocular and adnexal tumours.
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  Mentions: Cleveland Clinic
3. Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key
  
  Explore Gastroenterology & Endoscopy News Feb 24 2014 Gastroenterology , Oncology
  
  Radiofrequency ablation (RFA) in Barrett’s esophagus (BE) patients with low-grade dysplasia (LGD) provides significant protection against progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of RFA relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said the senior author of the study, Jacques J ...
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  Mentions: Boston Scientific University of North Carolina Olympus
4. Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.
  
  Explore Home (World Scientific) Feb 18 2014 Oncology
  
  Pre-operative X-ray mammography and intraoperative X-ray specimen radiography are routinely used to identify breast cancer pathology. Recent advances in optical coherence tomography (OCT) have enabled its use for the intraoperative assessment of surgical margins during breast cancer surgery. While each modality offers distinct contrast of normal and pathological features, there is an essential need to correlate image -based features between the two modalities to take advantage of the diagnostic capabilities of each technique. We compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-time intraoperative OCT imaging . X-ray ...
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  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney
5. Fast diagnostic cancer imaging technique displayed at Photonics West 2014
  
  Explore Vision Systems Design Feb 6 2014 Oncology , Other Business News
  
  One of the numerous technologies and applications being highlighted at Photonics West 2014 was a non-invasive optical imaging system used to quickly obtain images at the cellular level to assist in diagnoses and biopsies. CAReIOCA began in 2012 as a collaborative project funded by the European Commission’s Seventh Framework Programme. The project saw the development of an imaging system with the purpose of providing a medical tool for better localization and analysis of cancer biopsies in the operating room in order to "reduce failure and reoperation rates in pre-operative diagnosis." CAReIOCA’s technical partners, LLTech , CMOSIS, and Adimec collaborated ...
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  Mentions: LLTech
6. Intraoperative assessment of margins in breast conserving therapy: A systematic review
  
  Explore The Breast Jan 29 2014 Oncology
  
  Approximately one quarter of patients undergoing breast conserving therapy for breast cancer will require a second operation to achieve adequate clearance of the margins. A number of techniques to assess margins intraoperatively have been reported. This systematic review examines current intraoperative methods for assessing margin status. The final pathology status, statistical measures including accuracy of tumour margin assessment, average time impact on the procedure and second operation rate, were used as criteria for comparison between studies. Although pathological methods, such as frozen section and imprint cytology performed well, they added on average 20–30 min to operation times. An ultrasound ...
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7. Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis
  
  Explore BioOptics World Jan 22 2014 Gastroenterology , Oncology
  
  Angle-resolved low coherence interferometry (a/LCI) directly measures diagnostically relevant sub-cellular features in epithelial tissues up to 500 μm below the surface. Unlike optical coherence tomography (OCT), which requires image interpretation, a/LCI performs analysis of tissue and delivers to the physician direct confirmation of precancerous disease. Because it offers the greatest opportunity for successful intervention and therapy, a key weapon in the fight against cancer is early detection. If disease can be found in the precancerous stage, before abnormal cells have had the chance to spread throughout the body, the efficacy of treatment can be quite high. The clinical ...
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  Mentions: Adam Wax FDA Oncoscope
8. Imaging of noncarious cervical lesions by means of a fast swept source optical coherence tomography system
  
  Explore Conference Proceedings Jan 15 2014 Dentistry , Oncology , Otolaryngology
  
  Non-carious cervical lesions (NCCL) are defined as the loss of tooth substance at the cemento-enamel junction and are caused by abrasion, erosion and/or occlusal overload. In this paper we proved that our fast swept source OCT system is a valuable tool to track the evolution of NCCL lesions in time. On several extracted bicuspids, four levels of NCCL were artificially created. After every level of induced lesion, OCT scanning was performed. B scans were acquired and 3D reconstructions were generated. The swept source OCT instrument used in this study has a central wavelength of 1050 nm, a sweeping range ...
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  Mentions: Adrian G. Podoleanu University of Kent Cosmin Sinescu
9. Imaging of oral pathological tissue using optical coherence tomography
  
  Explore Conference Proceedings Jan 15 2014 Oncology , Otolaryngology
  
  Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images ...
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  Mentions: Adrian G. Podoleanu University of Kent Cosmin Sinescu
10. Surgical margins in breast conservation
  
  Explore ScienceDirect Jan 4 2014 Oncology
  
  Breast cancer is the most common tumor affecting women worldwide. Breast-conserving therapy (BCT) followed by irradiation nowadays is the treatment of choice for early-stage disease; there is no difference in long-term survival between mastectomy and BCT combined with external radiotherapy. A positive margin is associated with increased risk of local recurrences after BCT for invasive breast cancer and ductal carcinoma in situ. The exact definition of an adequate surgical margin after breast cancer resection has long been debated among physicians and represents an area of considerable variation in clinical practice. There is a lack of standardization in the pathology methods ...
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11. Full field optical coherence tomography of prostate biopsies: A step towards pre-histological diagnosis?
  
  Explore ScienceDirect Dec 31 2013 Oncology , Urology
  
  Objectives To evaluate the value of full field optical coherence tomography (FFOCT) for cancer detection on prostate biopsies Patients and methods Eight consecutive patients who underwent prostate biopsies for an elevated PSA or suspicious DRE findings were included in the study. For each patient, one to three biopsy cores were imaged with FFOCT immediately after sampling. Images obtained were analyzed by a pathologist blinded to the pathological results, and classified into three categories: non-cancerous tissue, suspicion of malignancy and prostate carcinoma. A pathological correlation analysis was further performed. Results Sixteen biopsy cores were analyzed. The median FFOCT procedure time was ...
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12. Picturing Cervical Cancer
  
  Explore clinchem.org Dec 31 2013 Gynecology , Oncology
  
  The Pap smear has been used to test women for cervical cancer since its invention in 1928. With a simple swipe and smear, doctors have been able to use microscopic observation to detect cancerous activity. Because cervical cancer is one of the most preventable forms of cancer, the Pap smear revolutionized how we deal with the disease. Yet, worldwide, 275 000 women ( 1 ) still die from cervical cancer each year. That's because although the Pap is an efficient test, it requires elements such as facilities, follow-up visits, and trained cytology technicians, making it difficult to use in low- to ...
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  Mentions: David Levitz MobileOCT
13. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
  
  Explore Optical Coherence Tomography News Nov 10 2013 Oncology , Urology
  
  Optical Coherence Tomography (OCT) has proven a powerful tool for ophthalmologists to make clinical decisions for a wide range of blinding diseases and the there are now ~20 million ophthalmic OCT patient scans per year. Significant progress is also being made in intravascular imaging where OCT is emerging as a tool for both clinical decision making and the understanding of cardiovascular disease and development of new therapeutic tools. OCT also has the potential to impact the understanding, diagnosis, and treatment of some forms of cancer. There are many leading research groups around the world that are making excellent progress in ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
14. Detection of pH-induced aggregation of "smart" gold nanoparticles with photothermal optical coherence tomography
  
  Explore opticsinfobase.org Oct 28 2013 Oncology
  
  We report the feasibility of a novel contrast agent, namely “smart” gold nanoparticles (AuNPs), in the detection of cancer cells with photothermal optical coherence tomography (PT-OCT). “Smart” AuNPs form aggregation in low pH condition, which is typical for cancer cells, and this aggregation results in a shift of their absorption spectrum. A PT-OCT system was developed to detect this pH-induced aggregation by combining an OCT light source and a laser with 660 nm in wavelength for photothermal excitation. Optical detection of pH-induced aggregation was tested with solution samples at two different pH conditions. An increase in optical path length (OPL ...
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  Mentions: Ki Hean Kim Yonsei University Chulmin Joo
15. In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis
  
  Explore Landes Bioscience Home Oct 23 2013 Oncology
  
  Identification of the early microscopic changes associated with ovarian cancer may lead to development of a diagnostic test for high-risk women. In this study we use optical coherence tomography (OCT) and multiphoton microscopy (MPM) (collecting both two photon excited fluorescence [TPEF] and second harmonic generation [SHG]) to image mouse ovaries in vivo at multiple time points. We demonstrate the feasibility of imaging mouse ovaries in vivo during a long-term survival study and identify microscopic changes associated with early tumor development. These changes include alterations in tissue microstructure, as seen by OCT, alterations in cellular fluorescence and morphology, as seen by ...
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  Mentions: Jennifer K. Barton University of Arizona Urs Utzinger
16. Choroidal Melanocytosis Evaluation with Enhanced Depth Imaging Optical Coherence Tomography
  
  Explore Ophthalmology Oct 16 2013 Oncology , Ophthalmology
  
  Objective To assess eyes with unilateral choroidal melanocytosis using enhanced depth imaging (EDI) optical coherence tomography (OCT). Design Retrospective, observational case series. Participants Fifteen patients with unilateral choroidal melanocytosis. Methods Each patient was evaluated with EDI-OCT, and comparison was made of involved versus uninvolved foveal retinal and choroidal layers. Main Outcome Measures Enhanced depth imaging OCT features of choroidal melanocytosis. Results The mean patient age was 28 years (median, 23 years; range, 5–76 years). There were 9 male and 6 female patients. Best-corrected visual acuity ranged from 20/20 to 20/30. All patients had subfoveal involvement with choroidal ...
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  Mentions: Thomas Jefferson University Jerry A. Shields University of Milan
17. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells
  
  Explore SPIE | Journal Oct 12 2013 Oncology
  
  Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with AF imaging to characterize the AF attenuation due to the epithelium. We present imaging results from three vital tissue models, each consisting of a three-dimensional tissue culture grown from one ...
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  Mentions: British Columbia Cancer Agency Stephen Lam
18. Vascular Response to Brachytherapy Using Functional OCT
  
  Explore ClinicalTrials.gov Sep 30 2013 Oncology , Ophthalmology , Clinical Trials
  
  The purpose of this study is to learn how blood flows to tumors in patients treated with I-125 plaque brachytherapy for uveal melanoma. Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening cancer, and even eye-sparing therapy with radiation treatment often leads to significant loss of vision. Major challenges to providing care to patients with uveal melanoma include the inability to accurately predict long-term vision in an eye treated with radiation, due to a poor understanding of the nature of radiation retinopathy and optic neuropathy. Optical coherence tomography (OCT) is a commonly used ophthalmic imaging modality that ...
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  Mentions: David Huang Oregon Health & Science University
19. Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)
  
  Explore arizona.openrepository.com Sep 24 2013 Gastroenterology , Oncology , Student Theses
  
  Optical coherence tomography (OCT) is an imaging method that is considered the optical analog to ultrasound, using the technique of optical interferometry to construct two-dimensional depth-resolved images of tissue microstructure. With a resolution on the order of 10 μm and a penetration depth of 1-2 mm in highly scattering tissue, fiber optics-coupled OCT is an ideal modality for the inspection of the mouse colon with its miniaturization capabilities. In the present study, the complementary modalities laser-induced fluorescence (LIF), which offers information on the biochemical makeup of the tissue, and surface magnifying chromoendoscopy, which offers high contrast surface visualization, are combined ...
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  Mentions: University of Arizona
20. Uncovering Cancer’s Inner Workings by Capturing Live Images of Growing Tumors
  
  Explore Optical Coherence Tomography News Sep 17 2013 Oncology
  
  Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease. Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics ( FiO ), The Optical Society’s ( OSA ) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and ...
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  Mentions: Massachusetts General Hospital Harvard University
21. University of Illinois at Urbana-Champaign Receives NIH Grant for Interaoperative OCT for Determining Lymph Node Status and Staging Cancer
  
  Explore Optical Coherence Tomography News Sep 11 2013 Oncology , Funding
  
  The University of Illinois at Urbana-Champaign Received a 2013 NIH Grant for $559,530 for Interaoperative OCT for Determining Lymph Node Status and Staging Cancer. The principal investigator is Stephen Boppart. The program began in 2010 and ends in 2014. Below is a summary of the proposed work. The surgical treatment of solid tumors frequently involves the resection and post-operative histopathological assessment of sentinel and loco-regional lymph nodes to determine the extent to which the cancer may have spread. This information is also used to stage the disease. The stage of the disease determines the prognosis and dictates treatment strategies ...
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  Mentions: National Institutes of Health Stephen A. Boppart University of Illinois at Urbana-Champaign
22. Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening
  
  Explore ScienceDirect Sep 10 2013 Oncology
  
  In vitro three-dimensional models of cancer have the ability to recapitulate many features of tumors found in vivo , including cell–cell and cell–matrix interactions, microenvironments that become hypoxic and acidic, and other barriers to effective therapy. These model tumors can be large, highly complex, heterogeneous, and undergo time-dependent growth and treatment response processes that are difficult to track and quantify using standard imaging tools. Optical coherence tomography is an optical ranging technique that is ideally suited for visualizing, monitoring, and quantifying the growth and treatment response dynamics occurring in these informative model systems. By optimizing both optical coherence tomography ...
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  Mentions: Massachusetts General Hospital Harvard University
23. SKINTELL from Agfa HealthCare in the picture at the International Summer Academy (ISA) in Munich
  
  Explore Agfa HealthCare — Aug 13 2013 Dermatology , Oncology , Other Business News
  
  Thanks to Dr. Tanja Maier from the Ludwig Maximilian University (LMU) in Munich a dedicated high-quality workshop took place around Agfa HealthCare’s me first technology, called High-Definition Optical Coherence Tomography (HD-OCT), The lecture from Dr. Maier was focused on non-melanoma skin cancers. A SKINTELL demonstration was given and all kinds of images from various skin diseases were discussed. The attendees took the opportunity to use this non-invasive technology and to take images themselves. Our booth received great interest and in this regard many demonstrations were given to dermatologists and young, upcoming dermatologists. During this congress that took place from ...
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  Mentions: AGFA Healthcare AGFA SKINTELL
24. University of Arizona Receives NIH Grant for Dual Modality System for Imaging Colon Cancer in Mice
  
  Explore Optical Coherence Tomography News Aug 6 2013 Gastroenterology , Oncology , Funding
  
  University of Arizona Received a 2013 NIH grant for $285,247 for Dual Modality System for Imaging Colon Cancer in Mice. The principal investigator was Jennifer Barton. The program began in 2004 and ends in 2014. Below is a summary of the work. Mouse models of colon cancer are a critical experimental tool for determining the role of specific genes in carcinogenesis, studying tumor initiation and progression, and testing potential chemopreventive and therapeutic compounds. Typically, mouse study outcomes are determined by sacrifice and colon tissue harvesting for procedures such as tumor count, immunohistochemistry, and various assays. Since each animal can ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
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