1. Articles in category: Oncology

    1-24 of 479 1 2 3 4 ... 18 19 20 »
    1. OCT helps identify cancerous brain tissue

      OCT helps identify cancerous brain tissue

      A brain cancer diagnosis can represent a death sentence, with remaining life measured in months to a year or so. Neurosurgery can increase the predicted survival time by up to 200%, depending upon the amount of tumour that can be resected. Distinguishing cancerous tissue from healthy brain tissue can be difficult, however, especially when it has infiltrated white matter. Current imaging detection technologies are suboptimal. Optical coherence tomography (OCT) offers the potential to identify cancerous brain tissue during surgery in an efficient and cost-effective manner. OCT can provide high-resolution volumetric imaging to a millimetre depth and deliver continuous, quantitative feedback ...

      Read Full Article
    2. Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Optical coherence tomography (OCT) is a non-invasive imaging tool used in-vivo, in real time for diagnosis, treatment delineation and monitoring of basal cell carcinomas (BCC) treatment. Features of BCC on OCT have been widely described and reviewed. However, the diagnostic accuracy of OCT in these various applications are unclear. We systematically reviewed the literature to assess the accuracy of OCT in diagnosis and management of BCC using the Embase and Medline databases. 179 unique references were identified in the initial search. 22 studies with 556 histologically-proven BCC were eligible. Assessment of quality of eligible studies was undertaken using the STROBE ...

      Read Full Article
    3. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Background A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes. Methods Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric ...

      Read Full Article
    4. Optical Coherence Tomography/Brain Surgery: OCT-based approach facilitates brain cancer surgery

      Optical Coherence Tomography/Brain Surgery: OCT-based approach facilitates brain cancer surgery

      "As a neurosurgeon, I'm in agony when I'm taking out a tumor. If I take out too little, the cancer could come back; too much, and the patient can be permanently disabled," says Alfredo Quinones-Hinojosa, MD, professor of neurosurgery, neuroscience, and oncology at the Johns Hopkins University School of Medicine. "We think optical coherence tomography has strong potential for helping surgeons know exactly where to cut," he adds. Carmen Kut, an MD/PhD student working in the biomedical engineering lab of Xingde Li, Ph.D., thought OCT might provide a solution to the problem of separating brain cancers ...

      Read Full Article
    5. Optical coherence tomography in the assessment of oral squamous cell carcinoma resection margins

      Optical coherence tomography in the assessment of oral squamous cell carcinoma resection margins

      Background Incomplete surgical removal of cancer is believed to be the main cause of local recurrence and high mortality. This study assessed the use of optical technology (namely optical coherence tomography [OCT]) in examining oral squamous cell carcinoma (OSCC) resection margins to assess if this modality could guide the surgeon during surgical resections. Materials and methods Twenty-eight T1-T2 N0M0 oral squamous cell carcinoma patients participated in this study. Nineteen patients were males and nine were females. The majority of lesions were in the ventro-lateral tongue, floor of mouth, retromolar trigone and the buccal mucosa. Following tumour resection, the specimen resection ...

      Read Full Article
    6. Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores

      Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores

      Objectives To evaluate the diagnostic accuracy (Acc) of full-field optical coherence tomography (FFOCT) for cancer detection on prostate biopsy. Materials and methods Thirty-eight consecutive patients with elevated PSA and/or suspicious digital rectal examination were prospectively included. For each patient, 1–10 cores were randomly selected and imaged with FFOCT immediately after sampling. The images obtained were de-identified and analyzed by three pathologists blinded to the results of pathological evaluation. The overall average Acc was measured, as well as sensitivity (Se), specificity (Sp), positive and negative predictive values (PPV and NPV). The Acc learning curve was assessed by multivariate logistic ...

      Read Full Article
    7. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives NIH Grant  for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      The University of Illinois Urbana-Champaign Receives a 2015 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investigator is Stephen Boppart. The program begain in 2012 and ends in 2017. Below is a summary of the proosed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...

      Read Full Article
    8. Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography

      Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography

      More complete brain cancer resection can prolong survival and delay recurrence. However, it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at the transitional, infiltrative zones. This is especially critical in eloquent regions (for example, speech and motor areas). This study tested the feasibility of label-free, quantitative optical coherence tomography (OCT) for differentiating cancer from noncancer in human brain tissues. Fresh ex vivo human brain tissues were obtained from 32 patients with grade II to IV brain cancer and 5 patients with noncancer brain pathologies. On the basis of volumetric OCT imaging data, pathologically confirmed brain cancer tissues ...

      Read Full Article
    9. Imaging of 3D Tissue-Engineered Models of Oral Cancer Using 890 and 1300 nm Optical Coherence Tomography

      Imaging of 3D Tissue-Engineered Models of Oral Cancer Using 890 and 1300 nm Optical Coherence Tomography

      Optical coherence tomography (OCT) generates its primary form of contrast from elastic backscatter. It is now the gold standard technique for retinal screening and is emerging rapidly in cardiovascular research however it remains a research goal to establish it to the same degree in epithelial cancer detection and diagnosis. In this report we compare two different OCT systems: an 890 nm spectrometer-based OCT system with 2.5 µm axial resolution and a 1300 nm swept-source OCT system with 7.5 µm axial resolution to determine the effect of these different OCT parameters on the endogenous backscatter contrast of dysplastic/malignant ...

      Read Full Article
    10. Taiwanese researchers find way to detect skin cancer early

      Taiwanese researchers find way to detect skin cancer early

      A research team at prestigious National Taiwan University (NTU) has developed a non-invasive technology that can help detect melanoma, the most deadly type of skin cancers, by up to six months earlier than usual. The team hopes its high-speed and high resolution optical coherence tomography scanner can receive medical certification by as early as 2017 so that it can put it into clinical use as soon as possible. Diagnosing cancer relies primarily on observing tissues and cells, and that is where the scanner can be useful in a timely way, said Shun Chia-tung, a doctor with National Taiwan University Hospital ...

      Read Full Article
    11. Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts

      Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts

      A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...

      Read Full Article
    12. “How Does Breast Cancer Develop?” Pilot Grants Awarded to Multidisciplinary Teams Using the Intraductal Approach to Advance Breast Cancer Prevention

      “How Does Breast Cancer Develop?” Pilot Grants Awarded to Multidisciplinary Teams Using the Intraductal Approach to Advance Breast Cancer Prevention

      Dr. Sheldon Feldman and Dr. Fatih Balci study intraductal approaches to breast cancer. They are currently investigating the effectiveness of optical coherence tomography (OCT), which is used in cardiology to look at blood vessels from the inside using light instead of sound (as an ultrasound does) to create three-dimensional images. OCT may be able to identify early changes in the breast duct before ductal carcinoma in situ (DCIS) or cancer forms. This consortium received $17,000 to study whether it is feasible to use OCT to distinguish different types of breast cells and tissues and whether OCT can show features ...

      Read Full Article
    13. Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography

      Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography

      We have estimated the micro-mechanical properties of ovarian tissue using phase-sensitive swept source optical coherence tomography. Ovary samples were mechanically excited by periodical vibration of an ultrasound transducer. The displacement and strain of the tissues were calculated during loading. Significant difference in strain was observed between the normal and malignant ovary groups, which indicates much softer and heterogeneous tissue structure for malignant ovaries. The initial results show that the phase sensitive swept source optical coherence elastography (OCE) can be an effective tool for characterization of stiffness and other micro-mechanical properties of normal and malignant ovarian tissue.

      Read Full Article
    14. Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer

      Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer

      Diagnosis of peripheral lung nodules is challenging because they are rarely visualized endobronchially. Imaging techniques such as endobronchial ultrasound (EBUS) are employed to improve tumor localization. The current EBUS probe provides limited nodule characterization and has an outer diameter of 1.4 mm that restricts access to small peripheral airways. We report a novel co-registered autofluoresence Doppler optical coherence tomography (AF/DOCT) system with a 0.9 mm diameter probe to characterize peripheral lung nodules prior to biopsy in vivo. Method: Patients referred for evaluation of peripheral lung nodules underwent bronchoscopy with examination of standard EBUS and the novel AF ...

      Read Full Article
    15. VivoSightOCT Education Centre

      VivoSightOCT Education Centre

      Welcome to the VivoSight OCT Education Centre website This is an open access facility providing information about the use of Optical Coherence Tomography in Dermatology. Please feel free to browse using the navigation guides, We hope you will find the site useful. If you would like to contribute images or just give us some feedback please contact us on info@vivosightatlas.com

      Read Full Article
    16. OCT firm Michelson Diagnostics closes £2.5m 'Series B' funding

      OCT firm Michelson Diagnostics closes £2.5m 'Series B' funding

      Michelson Diagnostics , the UK-based medical device company focused on multi-beam Optical Coherence Tomography technology, has closed the £2.5m first tranche of its “Series B” financing, led by strategic investor and medical specialist Smith & Nephew alongside new investor Kent County Council as well as existing investors. The £2.5m investment will be used to expand Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-center clinical biopsy avoidance study; and explore further applications in wound care and dentistry. VivoSight is a point-of-care tissue-imaging system that for the first time ...

      Read Full Article
    17. Optical coherence tomography predicts visual outcome for pituitary tumors

      Optical coherence tomography predicts visual outcome for pituitary tumors

      We evaluate if the relationship between optical coherence tomography (OCT) of the retinal nerve fibre layer (RNFL) continued over long-term visual recovery in 107 patients undergoing pituitary decompression. Recently, it has been recognized that OCT of RNFL has prognostic value in predicting visual outcomes after surgery for chiasmal compression caused by pituitary tumours. Patients were followed up at three time points: pre-operative (visit 1), 6 –10 weeks post-operative (visit 2) and 9–15 months follow-up (visit 3). We found that patients with thin pre-operative RNFL had more severe visual field defects (mean deviation [MD] -9.22 versus -3.96 decibels ...

      Read Full Article
    18. Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Gastrointestinal cancers are very difficult to diagnosis due to poor biopsy and diagnosis techniques. The invention is a device that is minimally invasive and improves biopsy technique by enabling the physician to visualize a tissue in real time prior to its biopsy. This allows for improved biopsy collection and thereby increases the diagnosis accuracy. FULL DESCRIPTION Gastrointestinal (GI) cancers cause 140,000 deaths and more than 290,000 new cases in the US in 2014. These include esophageal, colorectal cancer and many others. The current standard for early diagnosis of GI cancers is to perform histological analysis based on biopsy ...

      Read Full Article
    19. Feature Of The Week 01/25/15: Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer.

      Feature Of The Week 01/25/15: Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer.

      Prostate cancer (PCa) is the most common non-cutaneous malignancy in men. Men suspected with PCa are then offered transrectal ultrasound (TRUS) guided prostate biopsies to confirm the diagnosis, which falls short of making a reliable differentiation between cancer and benign hyperplasia of the gland. Suspected cancerous lesions tend to be stiffer (or harder to feel) than benign tissue. Various elastography modalities such as Ultrasound elastography and MRI elastography are known to have poor spatial resolution, which limits their ability to differentiate small lesions and in identifying early and subtle changes. OCT is an optical imaging technique that enables high-resolution, cross-sectional ...

      Read Full Article
    20. The Role of Optical Coherence Tomography in Intracranial Tumor in a Child – Case Report

      The Role of Optical Coherence Tomography in Intracranial Tumor in a Child – Case Report

      We report the case of a three-year-old child referred to the Neuro-ophthalmology Department with the diagnosis of benign intracranial tumor in close relation to the left optic nerve and to the optic chiasm. Visual acuity, intrinsic and extrinsic ocular motility and fundoscopy were normal and without asymmetries. Given the age of the child and the impossibility of performing perimetry, we decided to perform visual evoked potentials and Optical Coherence Tomography (OCT) of the optic nerve, with measurement of the peripapillary retinal nerve fiber layer. The result was considered normal and symmetrical. The tomographic study the optic nerve, combined with visual ...

      Read Full Article
    21. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.

      University of North Carolina Receives NIH Grant for  Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.

      University of North Carolina at Chapel Hill Received at 2015 NIH Grant for $142,199 for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment. The principal investigator is Amy Oldenburg. The program began in 2014 and ends in 2015. Below is as summary of the proposed work. With no available targeted therapies, basal-like breast cancers are particularly aggressive cancers with a poor prognosis. Basal-like breast cancers have unique stromal-epithelial interactions within their microenvironments. The availability of quantitative 3D tissue culture assays to measure the response of basal-like cell line models in their microenvironments may lead to new ...

      Read Full Article
    22. Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

      Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

      The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six ...

      Read Full Article
    1-24 of 479 1 2 3 4 ... 18 19 20 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) Johns Hopkins University
    2. (1 articles) University of Illinois at Urbana-Champaign
  4. People in the News

    1. (1 articles) Gordon Mckenzie
    2. (1 articles) Andrew Cittadine
    3. (1 articles) P. Scott Carney
    4. (1 articles) Xingde Li
    5. (1 articles) Stephen A. Boppart
  5. OCT Companies in the News

    1. (1 articles) Diagnostic Photonics
    2. (1 articles) Michelson Diagnostics