Oncology -Optical Coherence Tomography News

Articles in category: Oncology

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1. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins
  
  Explore OSA | OSA Publishing Sep 20 2016 Oncology
  
  Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a ...
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  Mentions: David D. Sampson University of Western Australia Brendan F. Kennedy
2. Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer
  
  Explore Optical Coherence Tomography News Sep 20 2016 Oncology
  
  Combining wide-field micro-elastography with Optical Coherence Tomography (OCT), an Australian research team have developed a new imaging tool to detect malignant tissue during surgery that offers the potential to dramatically reduce the number of reoperations for patients with breast cancer Every year, an estimated 1.6 million women are diagnosed with breast cancer worldwide. It is one of the most common forms of cancer to affect women, second only to skin cancer. It is also deadly, killing an estimated 522,000 women annually. The development of mammography technologies has aided in the detection of earlier stage breast cancers. As a ...
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  Mentions: Christoph K. Hitzenberger Medical University of Vienna David D. Sampson
3. Jennifer Barton a Leader in Cancer research, Imaging Honored with 2016 SPIE President’s and Directors’ Awards
  
  Explore prweb.com Sep 15 2016 Gynecology , Oncology
  
  Jennifer Barton is the recipient of this year’s SPIE President’s Award and Majid Rabbani of the SPIE Directors’ award, Robert Lieberman, 2016 President of SPIE the international society for optics and photonics, announced at an awards banquet during SPIE Optics + Photonics 2016 in San Diego, California, on 31 August. Barton is interim director of the BIO5 Institute at the University of Arizona, which works to solve complex biology-based problems affecting humanity. She is also professor of biomedical engineering, electrical and computer engineering, optical sciences, and agricultural and bio-systems engineering at UA. Barton is known for her innovative use ...
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  Mentions: Jennifer K. Barton University of Arizona
4. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography
  
  Explore IOPscience Sep 13 2016 Oncology
  
  In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are scant. We present the novel application of an imaging technique, Inverse Spectroscopic Optical Coherence Tomography, for the non-destructive measurement of in vitro biological samples during matrix remodeling. Our findings indicate ...
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  Mentions: Northwestern University Vadim Backman University of Minnesota
5. Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography
  
  Explore Wiley Online Library Sep 12 2016 Oncology
  
  Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may prove challenging. Observations of breast cancer on multiple length scales, by OCE, ultrasound elastography, and atomic force microscopy, have shown an increase in the mechanical heterogeneity of malignant breast tumors ...
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  Mentions: David D. Sampson University of Western Australia Brendan F. Kennedy
6. Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma
  
  Explore OSA | OSA Publishing Sep 6 2016 Dermatology , Oncology
  
  Optical coherence tomography (OCT) is fast emerging as an additional non-interventional modality for skin tumor detection and diagnosis. A master/slave flying spot OCT configuration was assembled to detect periocular basal cell carcinomas (BCC). A swept source at 1300 nm and sweeping speed of 50 kHz were used. A three-step process was involved. First, 384 channeled spectra using a mirror were stored for 384 optical path differences at the master stage. Then, the stored channeled spectra (masks) were correlated with the channeled spectrum from the BCC tissue to produce 384 en face OCT images ( 200 × 200 pixels) for the optical ...
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  Mentions: Adrian G. Podoleanu University of Kent Adrian Bradu
7. Optical Coherence Tomography for Skin Cancer
  
  Explore LWW Online Sep 1 2016 Dermatology , Microscopy , Oncology
  
  Skin cancer is the most common malignancy worldwide, and non-melanoma skin cancers (NMSC) in particular, including basal cell carcinomas (BCC) and squamous cell carcinomas, constitute around 80 percent of all skin cancers. It is estimated that approximately 3.5 million new cases of NMSC occur every year in the U.S., exceeding that of all other cancers combined. Despite the high prevalence of NMSC, they can be effectively treated and cured with low recurrence when detected at an early stage. BCCs are known to be slow growing and rarely metastasize to other parts of the body; however, if left untreated ...
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  Mentions: Michelson Diagnostics Orit Markowitz
8. Morphologic features of basal cell carcinoma using the en-face mode in frequency domain optical coherence tomography
  
  Explore Wiley Online Library Sep 1 2016 Dermatology , Oncology
  
  Background Optical coherence tomography (OCT) has become a valuable non-invasive tool in the in vivo diagnosis of non-melanoma skin cancer, especially of basal cell carcinoma (BCC). Due to an updated software-supported algorithm, a new en-face mode – similar to the horizontal en-face mode in high-definition OCT and reflectance confocal microscopy – surface-parallel imaging is possible which, in combination with the established slice mode of frequency domain (FD-)OCT, may offer additional information in the diagnosis of BCC. Objectives To define characteristic morphologic features of BCC using the new en-face mode in addition to the conventional cross-sectional imaging mode for three-dimensional imaging of ...
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9. In vivo endoscopic Doppler optical coherence tomography imaging of the colon
  
  Explore Wiley Online Library Aug 22 2016 Gastroenterology , Oncology
  
  Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler OCT ...
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  Mentions: Jennifer K. Barton University of Arizona
10. Study of Imaging Characteristics OCT of Skin Lesions Requiring Biopsy / Resection (OCTSKIN)
  
  Explore Home - ClinicalTrials.gov Jul 28 2016 Dermatology , Oncology , Clinical Trials
  
  The diagnosis of cutaneous lesions often involves the use of surgical and invasive procedures such as biopsy or excision in order to analyze the structure and appearance of the fabric pathologists. With recent advances in optical and electronic fields, considerable efforts were produced to build high-performance optical instruments, able to transcribe the internal structure of the skin with varying degrees of depth and variable resolution. The imagery is now an area of great interest for medical diagnosis: non-invasive, quick, and in real time. This area is booming and new optical instruments are created to eventually be able to offer a ...
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11. Drs. Campbell, Hariri, and Lehman Receive 2016 LUNGevity Career Development Awards
  
  Explore cbs8.com Jul 18 2016 Oncology , Pulmonology , Funding
  
  Lida Hariri , MD, Massachusetts General Hospital, who will use a novel high-resolution imaging technique called Optical Coherence Tomography to perform virtual optical biopsies to determine its value in complementing tissue biopsies in the determination of early-stage lung cancer
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  Mentions: Vanderbilt University Massachusetts General Hospital Harvard University
12. Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour
  
  Explore Nature Publishing Group Jul 2 2016 Oncology , Probes
  
  Identifying tumour margins during breast-conserving surgeries is a persistent challenge. We have previously developed miniature needle probes that could enable intraoperative volume imaging with optical coherence tomography. In many situations, however, scattering contrast alone is insufficient to clearly identify and delineate malignant regions. Additional polarization-sensitive measurements provide the means to assess birefringence, which is elevated in oriented collagen fibres and may offer an intrinsic biomarker to differentiate tumour from benign tissue. Here, we performed polarization-sensitive optical coherence tomography through miniature imaging needles and developed an algorithm to efficiently reconstruct images of the depth-resolved tissue birefringence free of artefacts. First ex ...
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  Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University
13. OCT Technology Improves Diagnosis of Skin Cancer
  
  Explore MedicalResearch.com Jun 21 2016 Dermatology , Oncology
  
  As part of an ongoing series of occasional article on cancer prevention, Dr. Markowitz from The Mount Sinai Hospital discusses skin cancer and the use Optical Coherence Tomography in skin cancer diagnosis and treatment. MedicalResearch.com: How common is the problem of non-melanoma skin cancer? Are they difficult to detect and treat? Dr. Markowitz: Skin cancer is the most commonly diagnosed cancer in the United States. Non melanoma skin cancers, including basal cell carcinomas and squamous cell carcinomas, are the most common malignancies of the skin, constituting around 80 percent of all skin cancers. The annual cost of treating skin ...
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  Mentions: Orit Markowitz
14. A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high-definition optical coherence tomography
  
  Explore Wiley Online Library Jun 17 2016 Dermatology , Oncology
  
  Background High-definition optical coherence tomography (HD-OCT) features of actinic keratosis (AK) may aid in its diagnosis and therapeutic strategy. A diagnostic algorithm permitting discrimination of AK from squamous cell carcinoma (SCC) and normal skin has been proposed. However, diagnostic accuracy strongly depends on the experience of physicians. In two recent studies, it was demonstrated that HD-OCT permits to quantify in vivo optical properties such as light attenuation in intrinsic ageing skin, in melanocytic lesions and in basal cell carcinoma. This approach seems to permit a semiautomated classification of lesions easier to handle by non-experts. Objectives The aim of this paper ...
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  Mentions: University of Copenhagen Gregor B. E. Jemec
15. High efficiency for prostate biopsy qualification with full-field OCT after training
  
  Explore Conference Proceedings Jun 13 2016 Oncology , Urology
  
  Full-field optical coherence tomography (FFOCT) offers a fast and non-destructive method of obtaining images of biological tissues at ultrahigh resolution, approaching traditional histological sections. In the context of prostate cancer diagnosis involving multiple biopsies, FFOCT could be used to validate the cores just after they are obtained in order to guide the number of biopsies to be performed. The aim of the study was to define and test a training protocol for efficient FFOCT prostate biopsy assessment. Three readers (a pathologist with previous experience with FFOCT, a pathologist new to FFOCT, and a urologist new to FFOCT) were trained to ...
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  Mentions: UCLA LLTech Eugénie Dalimier
16. Kif14 overexpression accelerates murine retinoblastoma development
  
  Explore Wiley Online Library Jun 9 2016 Oncology
  
  The mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis. Genomic gain and/or overexpression of KIF14 has been documented in retinoblastoma and a number of other cancers, such as breast, lung and ovarian carcinomas, strongly suggesting its role as an oncogene. Despite evidence of oncogenic properties in vitro and in xenografts, Kif14's role in tumor progression has not previously been studied in a transgenic cancer model. Using a novel Kif14 overexpressing, simian virus 40 large T-antigen retinoblastoma (TAg-RB) double transgenic mouse model, we aimed to determine Kif14 's ...
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  Mentions: University of Ulster Indiana University Kobe University Graduate School of Medicine
17. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.
  
  Explore Optical Coherence Tomography News Jun 7 2016 Oncology , Funding
  
  University of Illionois at Urbana-Champaign Receives a 2016 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investiagator is Stephen Boppart. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...
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  Mentions: National Institutes of Health Stephen A. Boppart University of Illinois at Urbana-Champaign
18. Optical coherence tomography of basal cell carcinoma: density and signal attenuation
  
  Explore Wiley Online Library Jun 6 2016 Dermatology , Oncology
  
  Background Basal cell carcinoma (BCC) is the most prevalent malignancy in Caucasians. Optical coherence tomography (OCT) is a non-invasive optical imaging technology using the principle of interferometry. OCT has shown a great potential in diagnosing, monitoring, and follow-up of BCC. So far most OCT studies on the subject of BCC have had a qualitative focus, i.e. on morphological analysis of the OCT images. The aim of this study was to explore the use of quantitative OCT measurements, density, and attenuation coefficient in BCC lesions as a way to improve the OCT evaluation of BCC. Methods The study was based ...
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  Mentions: Gregor B. E. Jemec Lotte Themstrup
19. Longitudinal, label-free, quantitative tracking of cell death and viability in a 3D tumor model with OCT
  
  Explore Nature Publishing Group Jun 2 2016 Oncology
  
  Three-dimensional in vitro tumor models are highly useful tools for studying tumor growth and treatment response of malignancies such as ovarian cancer. Existing viability and treatment assessment assays, however, face shortcomings when applied to these large, complex, and heterogeneous culture systems. Optical coherence tomography (OCT) is a noninvasive, label-free, optical imaging technique that can visualize live cells and tissues over time with subcellular resolution and millimeters of optical penetration depth. Here, we show that OCT is capable of carrying out high-content, longitudinal assays of 3D culture treatment response. We demonstrate the usage and capability of OCT for the dynamic monitoring ...
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  Mentions: Massachusetts General Hospital Harvard University
20. UA engineers zero in on early detection of ovarian cancer
  
  Explore EurekAlert! May 31 2016 Gynecology , Oncology
  
  University of Arizona researcher Jennifer Barton is leading a two-year, $1 million project funded by the National Cancer Institute to identify imaging biomarkers of ovarian cancer, the most deadly gynecological cancer in the United States. This work may enable the first effective screening system for ovarian cancer. "Located deep in the body, with few early symptoms and no effective screening techniques, ovarian cancer has remained stubbornly difficult to understand, much less effectively combat," said Barton, professor of biomedical engineering, electrical and computer engineering, optical sciences, and agricultural and biosystems engineering, and interim director of the UA BIO5 Institute.
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  Mentions: National Cancer Institute Jennifer K. Barton University of Arizona
21. EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential
  
  Explore investor.biospace.com May 20 2016 Oncology , Funding
  
  Cancer diagnosis relies on the long and complex histology process. During surgery, there is currently no real- time guidance at the histology level, leading to up to 40% of reoperations . Along the cancer care workflow , in particular for tumor biopsy and excision, current existing preoperative and intraoperative imaging techniques fail to perform a reliable in situ diagnosis. Moreover, the complete pathological diagnosis, often based on histology slides preparation, is usually only available after a few days. For these reasons a significant number of patients need to undergo secondary biopsy or surgery. The CAReIOCA project combined the latest advances in CMOS ...
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  Mentions: Leiden University LLTech
22. An implant to catch metastatic cancer cells before they grow into tumors
  
  Explore Medical Xpress May 20 2016 Oncology , Funding
  
  There could be a way around this, though: a special imaging method under development at Northwestern University called Inverse Spectroscopic Optical Coherence Tomography (ISOCT). ISOCT detects molecular-level differences in the way cells in the body scatter light. And when we scan our implant with ISOCT, the light scatter pattern looks different when it's full of normal cells than when cancer cells are present. In fact, the difference is apparent when even as few as 15 out of the hundreds of thousands of cells in the implant are cancer cells. There's a catch – ISOCT cannot penetrate deep into tissue ...
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  Mentions: University of Michigan Northwestern University Rice University
23. Massachusetts General Hospital Receives NIH Grant for Octology: Histology using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News May 15 2016 Oncology , Funding
  
  Massachusetts General Hospital Receives a 2016 NIH Grant for $253,600 for Octology: Histology using Optical Coherence Tomography. The principal investigator is Burce Fischl. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. While histology remains the gold standard for assessing human neuroanatomy, the procedures for sectioning and hand mounting tissue for microscopic imaging are not substantially different than they were 100 years ago. These steps introduce irremediable distortions into the tissue sections making it difficult or impossible to align sections with suffiient accuracy to create 3D histological volumes at the micron ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
24. Ultrathin lensed fiber-optic probe for optical coherence tomography
  
  Explore OSA | OSA Publishing May 10 2016 Oncology
  
  We investigated and validated a novel method to develop ultrathin lensed fiber-optic (LFO) probes for optical coherence tomography (OCT) imaging. We made the LFO probe by attaching a segment of no core fiber (NCF) to the distal end of a single mode fiber (SMF) and generating a curved surface at the tip of the NCF using the electric arc of a fusion splicer. The novel fabrication approach enabled us to control the length of the NCF and the radius of the fiber lens independently. By strategically choosing these two parameters, the LFO probe could achieve a broad range of working ...
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