1. Articles in category: Oncology

    1-24 of 601 1 2 3 4 ... 23 24 25 »
    1. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the cell line HCT116. The spheroid RIs are compared to study the effect of growth time. To improve confocal microscopy imaging protocols, two immersion media (glycerol and ScaleView-A2) matching the spheroid ...

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    2. Toward an All-Optical Biopsy

      Toward an All-Optical Biopsy

      Combining multiple photonic imaging techniques could allow for new, noninvasive approaches to tumor detection and assessment, meeting clinical challenges at a time of rising global cancer incidence. [Getty Images] A compact experimental setup for multimodal nonlinear microscopy in clinical settings. [Leibniz-IPHT, S. Döring] Aging populations, exposure to environmental contamination in developing countries, and other factors are driving significant increases in cancer worldwide. The World Health Organization estimates that globally, the number of cancer cases will reach 21.6 million by 2030, nearly double the 14 million patients in 2012. In Germany alone, malignant tumors are responsible for a quarter ...

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    3. Melanoma Blood Vessel Changes Detected with OCT Imaging

      Melanoma Blood Vessel Changes Detected with OCT Imaging

      An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...

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    4. Optical probe at surgeon's fingertips for breast cancer removal

      Optical probe at surgeon's fingertips for breast cancer removal

      A finger-mounted probe is under development at the University of Western Australia to improve the surgical removal of breast cancer. This approach could be of value in scenarios where the use of a relatively bulky handheld probe is not convenient, such as when assessing if residual tumor is present in small cavities following excision of the main tumor mass in breast-conserving surgery. The device might also prove useful for brain and liver surgery and other types of cancer. A fiber probe incorporated into a wearable thimble uses quantitative micro-elastography (QME) to translate the The finger-mounted probe is placed perpendicular to ...

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    5. Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium

      Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium

      Congenital hypertrophy of retinal pigment epithelium (CHRPE) is a benign, pigmented, flat lesion arising from the retinal pigment epithelium (RPE). In this study, we describe optical coherence tomography angiography (OCTA) features of two eyes with solitary CHRPE. We found that the retinal vasculature over CHRPE was normal in both cases. We observed that in solitary CHRPE, segmentation artifacts can interfere in the interpretation of retinal vasculature due to thinning of the outer retina. Visualization of the underlying choroidal vasculature was obscured to some extent by masking effect of the hyperpigmented RPE. The choroidal vasculature was better appreciated on en face ...

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    6. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...

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    7. Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      The current gold standard for the clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients which can add an additional burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT), with its high-resolution and intermediate penetration depth, can potentially provide required diagnostic information noninvasively. Here we present an image analysis algorithm, 'optical properties extraction (OPE)', that improves the specificity and sensitivity of OCT by identifying unique ...

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    8. Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts

      Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts

      A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...

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    9. Volumetric analysis of breast cancer tissues using machine learning and swept-source optical coherence tomography

      Volumetric analysis of breast cancer tissues using machine learning and swept-source optical coherence tomography

      In breast cancer, 20%–30% of cases require a second surgery because of incomplete excision of malignant tissues. Therefore, to avoid the risk of recurrence, accurate detection of the cancer margin by the clinician or surgeons needs some assistance. In this paper, an automated volumetric analysis of normal and breast cancer tissue is done by a machine learning algorithm to separate them into two classes. The proposed method is based on a support-vector-machine-based classifier by dissociating 10 features extracted from the A-line, texture, and phase map by the swept-source optical coherence tomographic intensity and phase images. A set of 88 ...

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    10. Light-CT in the Diagnosis of Breast Tumor and Lymph Node

      Light-CT in the Diagnosis of Breast Tumor and Lymph Node

      Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability information of cells/tissue, which could be more important in cancer diagnosis. This study was to evaluate the feasibility and diagnostic value of FF-OCT and DCI in breast lesions and ...

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    11. OCT links blood vessels to melanoma type

      OCT links blood vessels to melanoma type

      A clinical study of malignant melanoma suggests that optical imaging of the most aggressive form of skin cancer could yield a faster assessment of particularly dangerous tumors. According to the UK-based optical coherence tomography (OCT) hardware developer Michelson Diagnostics , whose equipment was used in the study by four European dermatology research groups, the technique could offer a “short-cut” to identifying advanced cancers that have begun to spread. That might provide patients with a more aggressive or advanced tumor access to appropriate treatment more quickly, while those with less virulent melanomas could be spared invasive and expensive sentinel lymph-node biopsies that ...

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    12. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder wall for suspicious lesions with the ability to discriminate malignant tissue from healthy urothelium. Upon identification of degenerated tissue via OCT, RS was implemented to determine the molecular characteristics via ...

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    13. Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      It has been demonstrated that optical coherence micro-elastography (OCME) provides additional contrast of tumor compared to optical coherence tomography (OCT) alone. Previous studies, however, have predominantly been performed on mastectomy specimens. Such specimens typically differ substantially in composition and geometry from the more clinically relevant wide-local excision (WLE) specimens excised during breast-conserving surgery. As a result, it remains unclear if the mechanical contrast observed is maintained in WLE specimens. In this manuscript, we begin to address this issue by performing a feasibility study of OCME on 17 freshly excised, intact WLE specimens. In addition, we present two developments required to ...

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    14. Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. Ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.

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    15. Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      The benchmark method for the evaluation of breast cancers involves microscopic testing of a hematoxylin and eosin (H&E) stained tissue biopsy. Resurgery is required in 20‐30% of cases because of incomplete excision of malignant tissues. Therefore, a more accurate method is required to detect the cancer margin to avoid the risk of recurrence. In the recent years, convolutional neural networks (CNNs) has achieved excellent performance in the field of medical images diagnosis. It automatically extracts the features from the images and classifies them. In the proposed study, we apply a pre‐trained Inception‐v3 CNN with reverse active ...

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      Mentions: UCLA
    16. Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Purpose . Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Methods . Mastectomy and breast-conserving surgery specimens from 26 women were imaged with a handheld OCT probe. During standard pathology specimen dissection, representative 1-cm × 1-cm tissue regions were grossly identified, assessed with OCT, inked for orientation and ...

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    17. New Testing for Ovarian Cancer

      New Testing for Ovarian Cancer

      Optical coherence tomography (OCT) and multispectral fluorescence imaging (MFI) have demonstrated promising results in the early detection of ovarian cancer, as detailed in an abstract presented at the 12th Biennial Ovarian Cancer Research Symposium, held September 13–15 in Seattle. “There appear to be unique markers in the blood of ovarian cancer patients, months and years prior to diagnosis, and optical imaging techniques can distinguish [between] normal, cancer, and benign abnormalities [in] ovarian and fallopian tube tissue,” said presenter Jennifer K. Barton, PhD, professor of biomedical engineering at the University of Arizona in Tucson. Barton and colleagues are developing a ...

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    18. The utility of optical coherence tomography for diagnosis of basal cell carcinoma: A quantitative review

      The utility of optical coherence tomography for diagnosis of basal cell carcinoma: A quantitative review

      Background Optical coherence tomography (OCT) is a non‐invasive near‐infrared light imaging technology that can be utilized to diagnose basal cell carcinomas (BCCs) based on specific morphologic features. Objectives To conduct a quantitative review using tumor level data from published studies to assess i) in‐vivo diagnostic accuracy of different OCT systems; ii) correlation between OCT features and histopathological diagnosis; and iii) factors that impact accuracy of tumor depth estimation. Methods Primary tumor‐level data were extracted from published studies on use of time‐domain (TD‐OCT), frequency‐domain (FD‐OCT) or high‐definition (HD‐OCT) systems for diagnosis ...

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    19. Optical palpation for the visualization of tumor in human breast tissue

      Optical palpation for the visualization of tumor in human breast tissue

      Accurate and effective removal of tumor in one operation is an important goal of breast‐conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low‐resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In ...

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    20. OCT image atlas of healthy skin on sun‐exposed areas - O'Leary - - Skin Research and Technology - Wiley Online Library

      OCT image atlas of healthy skin on sun‐exposed areas - O'Leary - - Skin Research and Technology - Wiley Online Library

      Background Skin cancer represents the most prevalent type of cancer in the United States. Excision of these lesions can leave significant scarring, and a delay in the diagnosis of malignant melanoma could result in metastasis or death. Therefore, developing technology and criteria to accurately diagnose these cancers is of particular importance to the medical community. While biopsy can lead to scarring and infections, dermoscopy and confocal microscopy offer noninvasive imaging methods but are also limited in their ability to determine tumor depth and margins. Optical coherence tomography (OCT) is a promising imaging method that uses near‐infrared light backscattering to ...

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    21. Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model

      Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model

      Oral cancer is the 11th most common cancer worldwide, especially in a male adult. The median age of death in oral cancer was 55 years, 10-20 years earlier than other cancers. Presently, oral cancer is often found in late stage, because the lesion is often flat in early stage and is difficult to diagnose under traditional white light imaging. The only definitive method for determining cancer is an invasive biopsy and then using histology examination. How to detect precancerous lesions or early malignant lesions is an important issue for improving prognosis of oral cancer. Optical coherence tomography (OCT) is a ...

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    22. Trimodal system for in vivo skin cancer screening with combined OCT-Raman and co-localized optoacoustic measurements

      Trimodal system for in vivo skin cancer screening with combined OCT-Raman and co-localized optoacoustic measurements

      A new multimodal system for rapid, noninvasive in vivo skin cancer screening is presented, combining optical coherence tomography (OCT) and optoacoustic (OA) modalities to provide precise tumor depth determination with a Raman spectroscopic modality capable of detecting the lesion type and, thus, providing diagnostic capability. Both optoacoustic and Raman setups use wide field skin illumination to ensure the compliance with Maximum Permissible Exposure (MPE) requirements. The Raman signal is collected via the OCT scanning lens to maximize the signal-to-noise ratio (SNR) of the measured signal while keeping radiation levels below MPE limits. OCT is used to optically determine the tumor ...

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    23. Optical coherence tomography angiography in choroidal melanoma and nevus

      Optical coherence tomography angiography in choroidal melanoma and nevus

      Synopsis: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus. Objective: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography angiography (OCTA) in eyes with choroidal nevus from small malignant choroidal melanoma. Methods: In this retrospective, noninvasive, observational study, 11 patients diagnosed with small choroidal mass (five with choroidal nevus and six with malignant melanoma) who underwent dilated fundus examination, ocular ultrasonography and OCTA images were compared. Results: In choroidal nevus of all patients, OCTA demonstrated a hyporeflective mass ...

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    24. Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update

      Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update

      Actinic keratosis represents the earliest manifestation of non-melanoma skin cancer. Because of their risk of progression to invasive squamous cell carcinoma, an earlier diagnosis and treatment are mandatory. Their diagnosis sometimes could represent a challenge even for expert dermatologists. Dermoscopy, confocal laser microscopy and optical coherence tomography could help clinicians in diagnosis. .

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