1. Articles in category: Oncology

    1-24 of 608 1 2 3 4 ... 24 25 26 »
    1. Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Background The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy of optical coherence tomography in assessing cutaneous cancer margins of the face. Materials and Methods The excised tissue specimens that were examined, in this study, were acquired from 70 patients with 70 facial cancer lesions, with no nodal disease. Forty lesions were basal cell carcinomas (150 margins; 27 tumour positive) and ...

      Read Full Article
    2. Machine learning, imaging technique may boost colon cancer diagnosis

      Machine learning, imaging technique may boost colon cancer diagnosis

      Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal. Current colon cancer screening is performed by flexible colonoscopy. The procedure involves visual inspection of the mucosal lining of the colon and rectum with a camera mounted on an endoscope. Abnormal appearing areas are then biopsied for analysis. Although this is the current standard of ...

      Read Full Article
    3. Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography

      Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography

      Background Currently, positive margins at lumpectomy contribute to health care cost, patient anxiety, and treatment delay. Multiple technology solutions are being explored with the aim of lowering re‐excision rates for breast‐conserving surgery (BCS). We examined wide‐field optical coherence tomography (WF‐OCT), an innovative adjunct intraoperative imaging tool for tissue visualization of margins. Methods This IRB‐approved pilot study included women with invasive or in situ carcinoma scheduled for primary BCS. Lumpectomy specimens and any final/revised margins were imaged by optical coherence tomography immediately prior to standard histological processing. The optical coherence tomography used provided two‐dimensional ...

      Read Full Article
    4. Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques. The IHU-SPECTRA research unit, entirely dedicated to the development of fluorescence-guided surgery, was set up to test several innovations as part of a large-scale project (ELIOS: Endoscopic Luminescent Imaging for Precision Oncology Surgery), funded by the ARC Foundation for Cancer Research. The proposed research protocol is part of the ELIOS project and targets in particular colon tumours. The Holy Grail in oncology surgery is the radical removal of cancer cells in order to reduce the rate of tumour recurrences and increase ...

      Read Full Article
      Mentions: LLTech
    5. Analysis of low-scattering regions in optical coherence tomography

      Analysis of low-scattering regions in optical coherence tomography

      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering biological structures of interest. In a human tumor xenograft murine model, we show that these correspond to lymphatic vessels and nerves; extensive histopathologic validation studies are reported to unequivocally establish ...

      Read Full Article
    6. Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method

      Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method

      Background The purpose of this study was to develop a deep learning classification approach to distinguish cancerous from noncancerous regions within optical coherence tomography (OCT) images of breast tissue for potential use in an intraoperative setting for margin assessment. Methods A custom ultrahigh-resolution OCT (UHR-OCT) system with an axial resolution of 2.7 μm and a lateral resolution of 5.5 μm was used in this study. The algorithm used an A-scan-based classification scheme and the convolutional neural network (CNN) was implemented using an 11-layer architecture consisting of serial 3 × 3 convolution kernels. Four tissue types were classified, including adipose ...

      Read Full Article
    7. Corneal graphite deposit on anterior segment optical coherence tomography

      Corneal graphite deposit on anterior segment optical coherence tomography

      Retained intraocular graphite foreign bodies are uncommon and generally remain inert in the eye. A 16-year-old girl complained of a black spot on her right eye since 3 months following pencil tip trauma. Examination revealed a subconjunctival greyish-black nodular mass with a metallic sheen on the 5 O' clock limbus with involvement of the adjacent corneal stroma and endothelium [Figure 1] a. Optical coherence tomography revealed subconjunctival [ [Figure 1] b arrow], corneal stromal, and endothelial [ [Figure 1] b arrowhead] hyporeflective material with intense backshadowing. This visual impression will help differentiate pigmented conjunctivo--corneal lesion from other reported mimickers such as melanoma ...

      Read Full Article
    8. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the cell line HCT116. The spheroid RIs are compared to study the effect of growth time. To improve confocal microscopy imaging protocols, two immersion media (glycerol and ScaleView-A2) matching the spheroid ...

      Read Full Article
    9. Toward an All-Optical Biopsy

      Toward an All-Optical Biopsy

      Combining multiple photonic imaging techniques could allow for new, noninvasive approaches to tumor detection and assessment, meeting clinical challenges at a time of rising global cancer incidence. [Getty Images] A compact experimental setup for multimodal nonlinear microscopy in clinical settings. [Leibniz-IPHT, S. Döring] Aging populations, exposure to environmental contamination in developing countries, and other factors are driving significant increases in cancer worldwide. The World Health Organization estimates that globally, the number of cancer cases will reach 21.6 million by 2030, nearly double the 14 million patients in 2012. In Germany alone, malignant tumors are responsible for a quarter ...

      Read Full Article
    10. Melanoma Blood Vessel Changes Detected with OCT Imaging

      Melanoma Blood Vessel Changes Detected with OCT Imaging

      An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...

      Read Full Article
    11. Optical probe at surgeon's fingertips for breast cancer removal

      Optical probe at surgeon's fingertips for breast cancer removal

      A finger-mounted probe is under development at the University of Western Australia to improve the surgical removal of breast cancer. This approach could be of value in scenarios where the use of a relatively bulky handheld probe is not convenient, such as when assessing if residual tumor is present in small cavities following excision of the main tumor mass in breast-conserving surgery. The device might also prove useful for brain and liver surgery and other types of cancer. A fiber probe incorporated into a wearable thimble uses quantitative micro-elastography (QME) to translate the The finger-mounted probe is placed perpendicular to ...

      Read Full Article
    12. Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium

      Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium

      Congenital hypertrophy of retinal pigment epithelium (CHRPE) is a benign, pigmented, flat lesion arising from the retinal pigment epithelium (RPE). In this study, we describe optical coherence tomography angiography (OCTA) features of two eyes with solitary CHRPE. We found that the retinal vasculature over CHRPE was normal in both cases. We observed that in solitary CHRPE, segmentation artifacts can interfere in the interpretation of retinal vasculature due to thinning of the outer retina. Visualization of the underlying choroidal vasculature was obscured to some extent by masking effect of the hyperpigmented RPE. The choroidal vasculature was better appreciated on en face ...

      Read Full Article
    13. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...

      Read Full Article
    14. Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      The current gold standard for the clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients which can add an additional burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT), with its high-resolution and intermediate penetration depth, can potentially provide required diagnostic information noninvasively. Here we present an image analysis algorithm, 'optical properties extraction (OPE)', that improves the specificity and sensitivity of OCT by identifying unique ...

      Read Full Article
    15. Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts

      Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts

      A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...

      Read Full Article
    16. Volumetric analysis of breast cancer tissues using machine learning and swept-source optical coherence tomography

      Volumetric analysis of breast cancer tissues using machine learning and swept-source optical coherence tomography

      In breast cancer, 20%–30% of cases require a second surgery because of incomplete excision of malignant tissues. Therefore, to avoid the risk of recurrence, accurate detection of the cancer margin by the clinician or surgeons needs some assistance. In this paper, an automated volumetric analysis of normal and breast cancer tissue is done by a machine learning algorithm to separate them into two classes. The proposed method is based on a support-vector-machine-based classifier by dissociating 10 features extracted from the A-line, texture, and phase map by the swept-source optical coherence tomographic intensity and phase images. A set of 88 ...

      Read Full Article
    17. Light-CT in the Diagnosis of Breast Tumor and Lymph Node

      Light-CT in the Diagnosis of Breast Tumor and Lymph Node

      Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability information of cells/tissue, which could be more important in cancer diagnosis. This study was to evaluate the feasibility and diagnostic value of FF-OCT and DCI in breast lesions and ...

      Read Full Article
    18. OCT links blood vessels to melanoma type

      OCT links blood vessels to melanoma type

      A clinical study of malignant melanoma suggests that optical imaging of the most aggressive form of skin cancer could yield a faster assessment of particularly dangerous tumors. According to the UK-based optical coherence tomography (OCT) hardware developer Michelson Diagnostics , whose equipment was used in the study by four European dermatology research groups, the technique could offer a “short-cut” to identifying advanced cancers that have begun to spread. That might provide patients with a more aggressive or advanced tumor access to appropriate treatment more quickly, while those with less virulent melanomas could be spared invasive and expensive sentinel lymph-node biopsies that ...

      Read Full Article
    19. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder wall for suspicious lesions with the ability to discriminate malignant tissue from healthy urothelium. Upon identification of degenerated tissue via OCT, RS was implemented to determine the molecular characteristics via ...

      Read Full Article
    20. Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      It has been demonstrated that optical coherence micro-elastography (OCME) provides additional contrast of tumor compared to optical coherence tomography (OCT) alone. Previous studies, however, have predominantly been performed on mastectomy specimens. Such specimens typically differ substantially in composition and geometry from the more clinically relevant wide-local excision (WLE) specimens excised during breast-conserving surgery. As a result, it remains unclear if the mechanical contrast observed is maintained in WLE specimens. In this manuscript, we begin to address this issue by performing a feasibility study of OCME on 17 freshly excised, intact WLE specimens. In addition, we present two developments required to ...

      Read Full Article
    21. Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. Ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.

      Read Full Article
    22. Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      The benchmark method for the evaluation of breast cancers involves microscopic testing of a hematoxylin and eosin (H&E) stained tissue biopsy. Resurgery is required in 20‐30% of cases because of incomplete excision of malignant tissues. Therefore, a more accurate method is required to detect the cancer margin to avoid the risk of recurrence. In the recent years, convolutional neural networks (CNNs) has achieved excellent performance in the field of medical images diagnosis. It automatically extracts the features from the images and classifies them. In the proposed study, we apply a pre‐trained Inception‐v3 CNN with reverse active ...

      Read Full Article
      Mentions: UCLA
    23. Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Purpose . Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Methods . Mastectomy and breast-conserving surgery specimens from 26 women were imaged with a handheld OCT probe. During standard pathology specimen dissection, representative 1-cm × 1-cm tissue regions were grossly identified, assessed with OCT, inked for orientation and ...

      Read Full Article
    24. New Testing for Ovarian Cancer

      New Testing for Ovarian Cancer

      Optical coherence tomography (OCT) and multispectral fluorescence imaging (MFI) have demonstrated promising results in the early detection of ovarian cancer, as detailed in an abstract presented at the 12th Biennial Ovarian Cancer Research Symposium, held September 13–15 in Seattle. “There appear to be unique markers in the blood of ovarian cancer patients, months and years prior to diagnosis, and optical imaging techniques can distinguish [between] normal, cancer, and benign abnormalities [in] ovarian and fallopian tube tissue,” said presenter Jennifer K. Barton, PhD, professor of biomedical engineering at the University of Arizona in Tucson. Barton and colleagues are developing a ...

      Read Full Article
    1-24 of 608 1 2 3 4 ... 24 25 26 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) Washington University in St. Louis
    2. (1 articles) University College London
  4. People in the News

    1. (1 articles) Colin Hopper
    2. (1 articles) Quing Zhu