1. Articles in category: Oncology

    1-24 of 507 1 2 3 4 ... 20 21 22 »
    1. Orbital Metastasis From Breast Cancer without Significant Changes in CT Scan and MRI

      Orbital Metastasis From Breast Cancer without Significant Changes in CT Scan and MRI

      Dear Editor , Orbital metastasis infrequently occurs in breast cancer ( 1 ); however breast cancer is the most common cause of orbital metastasis ( 2 - 5 ), followed by lung, prostate, gastrointestinal tract, and skin (melanoma) cancers ( 6 , 7 ). Definite diagnosis of an orbital lesion includes an orbital biopsy (either FNA or open biopsy). However, in patients with known metastatic cancer, CT scan or MRI of the orbits can frequently show the presence of a mass, which often involves the orbital fat or extraocular muscles ( 4 , 5 ). On the other hand, these techniques may not completely reflect the metastases. Optical coherence tomography (OCT) is ...

      Read Full Article
    2. Optical coherence tomography in oral cancer: A transpiring domain

      Optical coherence tomography in oral cancer: A transpiring domain

      Identification of oral cancer at an early curable stage not only aids in controlling the mortality and morbidity rate but also improves the quality of life of the patient. Indeed, regular monitoring of such life-threatening disease has held an imperative role in cancer diagnostics. Various light-based diagnostics are currently available to the clinician for early diagnosis of oral cancer. Optical coherence tomography (OCT) is one such emerging light-based diagnostic modality that provides noninvasive, real-time images at a depth of 1.5–2 mm and can also be compared to corresponding histopathological sections, hence this procedure can also be referred as ...

      Read Full Article
    3. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      It is known that the progression of oral cancer is accompanied by changes in both tissue biochemistry and morphology. A multimodal imaging approach combining functional and structural imaging modalities could therefore provide a more comprehensive prognosis of oral cancer. This idea forms the central theme of the current study, wherein this premise is examined in the context of a multimodal imaging system that combines fluorescence lifetime imaging (FLIM) and optical coherence tomography (OCT). Towards this end, in the first part of the present study, the diagnostic advantage obtained by using both fluorescence intensity and lifetime information is assessed. In the ...

      Read Full Article
    4. Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Background— We previously described a strong association between fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection. Angiographic manifestations of coronary FMD aside from dissection were considered rare. However, we observed several coronary FMD angiographic abnormalities with corresponding optical coherence tomography abnormalities. Methods and Results— Baseline demographics and imaging of patients with suspected coronary FMD at Vancouver General Hospital were reviewed. Presence of multifocal (string-of-beads) extracoronary FMD was confirmed by 2 specialists. In these patients, coronary angiographic findings (excluding dissected segments) were reviewed and classified by 2 experienced angiographers for irregular stenosis, that is, stenosis with irregular borders in a focal ...

      Read Full Article
      Mentions: Hiram G. Bezerra
    5. Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and ...

      Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and ...

      New Skin Cancer Treatment Without Surgical Biopsy Available at Mount Sinai: Optical Coherence Tomography (OCT) is a non-invasive imaging modality that can visualize skin structure, and has been proven useful in evaluating the degree of sun damage in skin and identifying pre-cancerous lesions. Through the use of non-ablative lasers, Mount Sinai’s Dr. Markowitz, is one of the only experts in the U.S. using the device. She has been able to successfully treat — without cutting — both early and even more advanced non-melanoma skin cancers using OCT technology. According to Dr. Markowitz, non-melanoma skin cancers are not as deadly as ...

      Read Full Article
    6. Volumetric analysis of pathologies

      Volumetric analysis of pathologies

      Systems and methods are provided for volumetric analysis of pathologies. A segmentation component is configured to determine, for each of a series of images of a region of interest containing a pathological feature, a set of segmentation boundaries within the image representing a cross-section of the pathological feature. A mesh generation component is configured to link the sets of segmentation boundaries from adjacent images in the series of images to generate a polygonal mesh representing a volumetric reconstruction of the pathological feature. A volumetric measurement component is configured to calculate volumetric parameters from the volumetric reconstruction representing the pathological feature ...

      Read Full Article
    7. Measuring intracellular motion in cancer cell using optical coherence tomography

      Measuring intracellular motion in cancer cell using optical coherence tomography

      In this study, we demonstrate that OCT speckle decorrelation techniques can be used to probe intracellular motion in cancer cells. Spheroids and cell pellets were used as a model to probe intracellular motion. ZnCl 2 was used to inhibit mitochondrial motion within the cells. The results reveal the changes in intracellular motion during the spheroid growth phase. Moreover, to modify the motion of mitochondria, cell pellet were exposed to ZnCl 2 , and agent known to o impair cellular energy production through inhibition of mitochondrial function. The speckle decorrelation time during the growth phase of spheroids decreased by 35 ms over ...

      Read Full Article
    8. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

      Read Full Article
    9. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight ® , Callisto ® and Skintell ® . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness ...

      Read Full Article
    10. Chicago startup raises $3M for probe to prevent repeat cancer surgeries

      Chicago startup raises $3M for probe to prevent repeat cancer surgeries

      A c hicago-based company has raised $3.1 million to fund a clinical trial for its high-resolution imaging probes for cancer surgeons. Diagnostic Photonics, which launched in 2011 at the University of Illinois at Urbana-Champaign, hopes its technology will prevent multiple surgeries for cancer patients. The company is focusing efforts first on breast cancer because about 25 percent of affected women undergo multiple surgeries after lumpectomy, according to a study conducted by the University of Wisconsin Carbone Cancer Center in Madison. The repeat surgeries are often spurred by the “challenges of where does the cancer stop and normal tissues start ...

      Read Full Article
    11. Skin Cancer Biopsied by Optical Scan

      Skin Cancer Biopsied by Optical Scan

      Apollo Medical Optics Inc. (Taipei, Taiwan) aims to revolutionize skin cancer detection without the need for invasive biopsies by using a single-crystal sapphire and yttrium aluminium garnet crystalline fibers—surrounded by glass and a flexible polymer cladding—to look-through the skin and image suspicious skin anomalies non-invasively, instead of taking a skin sample and risk releasing malignant cancer cells into the bloodstream. The current prototype, using single-crystal sapphire at its core, is being integrated into a desktop unit that physicians can use in the office to identify skin cancer in a matter of minutes, determine its size and if small ...

      Read Full Article
    12. Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Background and Objectives We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC). Methods A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports. Results The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively ...

      Read Full Article
    13. Indo-US experts to develop solar-powered oral cancer detector

      Indo-US experts to develop solar-powered oral cancer detector

      Indian researchers along with US are working on a solar-powered device that could detect oral cancer at an early stage. It will enable faster and accurate diagnostics in rural areas through mobile technology. Designed by the Beckman Laser Institute (BLI), University of California-Irvine (UCI) and the Mazumdar Shaw Cancer Centre (MSCC) in Bengaluru, the compact screening and diagnosing system - slightly larger than a shoe box - has been specially adapted for India, which has one of the highest rates of head and neck cancers in the world and accounts for the highest rate among women. Its light-weight and user-friendly features mean ...

      Read Full Article
    14. Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Objective : To determine the diagnostic accuracy of optical coherence tomography for basal cell carcinoma and the proportion of biopsies that could be avoided if optical coherence tomography is used to rule-in surgery. Design : Multicenter, prospective, observational study. Setting : Dermatology clinics. Participants : Consecutive patients with clinically challenging pink lesions suspicious for basal cell carcinoma. Measurements : Clinical, dermoscopic, and optical coherence tomography images were obtained for all subjects. At each stage, the clinician made a diagnosis (pathology + subtype if applicable), and assessed his/her own confidence in the diagnosis. Results : Optical coherence tomography significantly (p<0.01) improved sensitivity and specificity over ...

      Read Full Article
    15. ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      Barrett’s esophagus (BE) is among the most common conditions encountered by the gastroenterologist. In this document, the American College of Gastroenterology updates its guidance for the best practices in caring for these patients. These guidelines continue to endorse screening of high-risk patients for BE; however, routine screening is limited to men with reflux symptoms and multiple other risk factors. Acknowledging recent data on the low risk of malignant progression in patients with nondysplastic BE, endoscopic surveillance intervals are attenuated in this population; patients with nondysplastic BE should undergo endoscopic surveillance no more frequently than every 3–5 years. Neither ...

      Read Full Article
    16. 'Ultrasound Using Light' May Aid Tumor Removal

      'Ultrasound Using Light' May Aid Tumor Removal

      Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact—and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient's brain showing which areas are and are not cancer. A summary of the research appears in the June 17 issue of Science Translational Medicine . "As a neurosurgeon, I'm in agony when ...

      Read Full Article
    17. Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Malignant tumor strongholds and their microscopic spies can’t hide in the thicket of flesh much longer, for surgeons have a new weapon: a device that sheds light on their location. Literally. “Any state of disease will alter the cells and molecules in our body,” said Dr. Stephen Boppart, a professor of bioengineering at the University of Illinois who invented the device. Every molecule scatters light different ways, he said, “leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave ...

      Read Full Article
    18. Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography

      Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography

      Background: Full-field optical coherence tomography (FFOCT) is a real-time imaging technique that rapidly generates images reminiscent of histology without any tissue processing, warranting its exploration for evaluation of ex vivo kidney tissue. Methods: Fresh tissue sections from tumor and adjacent nonneoplastic kidney ( n = 25 nephrectomy specimens; clear cell renal cell carcinoma (CCRCC) = 12, papillary RCC (PRCC) = 4, chromophobe RCC (ChRCC) = 4, papillary urothelial carcinoma (PUC) = 1, angiomyolipoma (AML) = 2 and cystic nephroma = 2) were imaged with a commercial FFOCT device. Sections were submitted for routine histopathological diagnosis. Results: Glomeruli, tubules, interstitium, and blood vessels were identified in nonneoplastic tissue. In ...

      Read Full Article
    19. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual presentation for the rapid identification of suspicious airway sites, while co-registered OCT provides detailed structural information to assess the airway morphology. We demonstrate the ability of AFI to visualize vascular ...

      Read Full Article
    20. University of California at Davis Receives NIH Grant for The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotheraputics.

      University of California at Davis Receives NIH Grant for The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotheraputics.

      University of California at Davis Receives a 2015 NIH Grant for $584,839 for The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotheraputics. The principal investigator is Kit Lam. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The rodent eye as a non-invasive window for understanding cancer nanotherapeutics Abstract: We propose to use the mouse eye as a non-surgical window for highly efficient, optical investigation of subretinal xenograft models and nanodelivery, using a state-of-the-art ocular imager, "EyePod". The EyePod employs single-cell resolution intravital confocal microscopy and optical coherence tomography ...

      Read Full Article
    21. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study - Ulrich - 2015 - British Journal of Dermatology - Wiley Online Library

      The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study - Ulrich - 2015 - British Journal of Dermatology - Wiley Online Library

      Background The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown. Objectives To investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy end point was a diagnosis of BCC for each lesion. Secondary end points were the diagnosis of other possible conditions. Methods This was an observational, prospective, multicentre study in which consecutive patients with nonpigmented pink lesions suspicious for BCC underwent clinical assessment, dermoscopy and OCT, with the diagnosis recorded at each stage. Once all diagnoses ...

      Read Full Article
    22. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of tissue microstructure. Previous studies have demonstrated that OCT analysis of excised tissue specimens can distinguish between normal and cancerous tissues by identifying the heterogeneous and disorganized microscopic tissue structures indicative ...

      Read Full Article
    23. New Imaging Technique Could Make Brain Tumor Removal Safer, More Effective, Study Suggests

      New Imaging Technique Could Make Brain Tumor Removal Safer, More Effective, Study Suggests

      Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact — and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient’s brain showing which areas are and are not cancer. A summary of the research appears June 17 in Science Translational Medicine . “As a neurosurgeon, I’m in agony when I’m taking ...

      Read Full Article
    24. Sponge-like implant that traps cancer cells may improve early detection

      Sponge-like implant that traps cancer cells may improve early detection

      Researchers can predict where cancer cells tend to spread, but figuring out how to trap them has been tricky. A new device created by engineers at the University of Michigan may help, a study published Tuesday in the journal Nature Communications suggests. A new device created by engineers at the University of Michigan may help, a study published Tuesday in the journal Nature Communications suggests. The mechanism, described as a small, sponge-like implant that captures metastatic cancer cells, could help detect the disease in healthy patients and prevent relapse in survivors, said the engineers who created the device. “We set ...

      Read Full Article
    1-24 of 507 1 2 3 4 ... 20 21 22 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) National Institutes of Health
    2. (1 articles) New York Eye and Ear Infirmary
    3. (1 articles) Texas A&M University
  4. People in the News

    1. (1 articles) Orit Markowitz
    2. (1 articles) Brian E. Applegate
    3. (1 articles) Hiram G. Bezerra
    4. (1 articles) Paritosh Pande
    5. (1 articles) Javier A. Jo
  5. OCT Companies in the News

    1. (1 articles) Heidelberg Engineering