1. Articles in category: Oncology

    1-24 of 621 1 2 3 4 ... 24 25 26 »
    1. Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery

      Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery

      Background Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full‐field optical coherence tomography (FFOCT) and dynamic cell imaging (DCI) are novel optical imaging techniques offering rapid histologic approximations that are unfettered by requisite handling steps. This study was conducted to determine the feasibility and diagnostic utility of FFOCT and DCI in examining breast and lymph node specimens during breast cancer surgery. Methods FFOCT and DCI were applied to normal and cancerous breast tissue, benign breast lesions, and resected axillary ...

      Read Full Article
      Mentions: LLTech
    2. Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

      Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

      Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this tissue. Here, an optical clearing agent (OCA) was applied topically to a cutaneous melanoma model in mice shortly before PDT to increase the effective treatment depth by reducing the light scattering. This was used together with cellular and vascular-PDT, or a combination of both. The effect on tumor growth was measured by longitudinal ultrasound/photoacoustic imaging in vivo and by immunohistology after sacrifice. In a separate dorsal window chamber tumor model, angiographic optical coherence tomography (OCT ...

      Read Full Article
    3. Optical coherence tomography imaging of excised canine apocrine gland anal sac adenocarcinoma tumors

      Optical coherence tomography imaging of excised canine apocrine gland anal sac adenocarcinoma tumors

      Optical coherence tomography (OCT) is an optical imaging modality that has been investigated for real‐time surgical margin evaluation in human breast cancer patients. Previous veterinary OCT studies have been limited to surgical margin imaging for soft tissue sarcoma (STS) tumors. To the authors knowledge, OCT has never been used to characterize or evaluate other types of neoplasia in dogs. The goal of this study was to characterize the OCT imaging appearance of apocrine gland anal sac adenocarcinoma (AGASACA) in excised ex vivo specimens from five client‐owned dogs. All excised tissue surgical margins were imaged using a clinical spectral ...

      Read Full Article
    4. Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumors

      Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumors

      Optical coherence tomography (OCT) uses near‐infrared light waves to generate real‐time, high‐resolution images on the microscopic scale similar to low power histopathology. Previous studies have demonstrated the use of OCT for real‐time surgical margin assessment for human breast cancer. The use of OCT for canine mammary tumors (CMT) could allow intra‐operative visualization of residual tumor at surgical margins. The purpose of this study was to assess OCT imaging for the detection of incomplete tumor resection following CMT surgery. We hypothesized that OCT images would have comparable features to histopathological images of tissues at the surgical ...

      Read Full Article
    5. Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

      Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

      Objective: To systematically evaluate the diagnostic efficacy of confocal laser endomicroscopy (CLE) in detection of bladder cancer. Methods: A systematic literature search on CLE in diagnosing bladder cancer in PubMed, Embase, and the Cochrane Library databases was performed. A bivariate meta-regression model was used for meta-analysis to evaluate the pooled diagnostic value of CLE. Results: A total of 5 eligible studies involving 302 lesions were available for this meta-analysis. In a per-lesion analysis, pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver-operating curve (SROC) area under the curve (AUC) of CLE ...

      Read Full Article
      Mentions: Fudan University
    6. The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe?

      The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe?

      Purpose: To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma. Methods: Records of 615 patients treated for choroidal melanoma between January 2017 and December 2019 were reviewed. Patients were excluded if iris and/or ciliary body involvement (106 patients), inadequate fundus photography (26 patients), no images available for review (21 patients) and/or treatment was not primary (11 patients). Demographic data and AJCC TNM Stage were collected. Color fundus and autofluorescence photographs (FAF), optical coherence tomography (OCT) and B-scan ultrasounds were prospectively reviewed. MOLES scores were assigned according to five criteria ...

      Read Full Article
    7. Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...

      Read Full Article
    8. University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk

      University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk

      University of Pittsburg Receives a 2020 NIH Grant for $437,317 for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk. The principal investigator is Yang Liu. Below is a summary of the proposed work. The effectiveness of colorectal cancer (CRC) screening, with a concomitant increased emphasis on detection of even the smallest adenomas, has resulted in a new clinical challenge. An increased number of people are being identified as harboring an adenomatous polyp, the benign precursor to CRC. These patients are recommended to undergo surveillance, or repeated colonoscopy for monitoring for recurrence ...

      Read Full Article
    9. Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...

      Read Full Article
    10. High-resolution Imaging Coupled With Elastography May Accurately Detect Breast Cancer in Surgical Margins

      High-resolution Imaging Coupled With Elastography May Accurately Detect Breast Cancer in Surgical Margins

      A high-resolution, three-dimensional imaging technique, when combined with quantitative measurement of tissue elasticity, could accurately detect cancer within the resected margins of surgical specimens taken from patients undergoing breast-conserving surgery, according to a study published in Cancer Research , a journal of the American Association for Cancer Research. “Despite living in the ‘digital age,’ surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery,” said Brendan F. Kennedy, PhD , associate professor in the School of Engineering at The University of Western Australia (UWA) and laboratory head of BRITElab ...

      Read Full Article
    11. High-res imaging with elastography may accurately detect breast cancer in surgical margins

      High-res imaging with elastography may accurately detect breast cancer in surgical margins

      Bottom Line: A high-resolution, three-dimensional imaging technique, when combined with quantitative measurement of tissue elasticity, could accurately detect cancer within the resected margins of surgical specimens taken from patients undergoing breast-conserving surgery. Journal in Which the Study was Published: Cancer Research , a journal of the American Association for Cancer Research Authors: Brendan F. Kennedy, PhD, associate professor in the School of Engineering at The University of Western Australia (UWA) and laboratory head of BRITElab at the Harry Perkins Institute of Medical Research in Perth, Western Australia; and Christobel Saunders, MBBS, professor in the School of Medicine at UWA Background: "Despite ...

      Read Full Article
    12. Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue micro‐architecture contrast

      Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue micro‐architecture contrast

      Effective intraoperative tumor margin assessment is needed to reduce re‐excision rates in breast‐conserving surgery (BCS). Mapping the attenuation coefficient in optical coherence tomography (OCT) throughout a sample to create an image (attenuation imaging) is one promising approach. For the first time, three‐dimensional OCT attenuation imaging of human breast tissue micro‐architecture using a wide‐field (up to ~45 × 45 × 3.5 mm) imaging system is demonstrated. Representative results from three mastectomy and one BCS specimen (from 31 specimens) are presented with co‐registered postoperative histology. Attenuation imaging is shown to provide substantially improved contrast over OCT, delineating ...

      Read Full Article
    13. Beating Cancer - One Patient at a Time

      Beating Cancer - One Patient at a Time

      Like most people, John Gifford wasn't looking forward to a colonoscopy when he arrived on the UCI Medical Center campus in Orange in 2018. The Riverside man, 65, was concerned about his family history of colorectal cancer and had dutifully scheduled an appointment with UCI Health gastroenterologist Dr. William Karnes. The exam turned out to be intriguing and enlightening - a far cry from what one expects during a colonoscopy, Gifford recalls with a laugh.

      Read Full Article
    14. Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Background The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy of optical coherence tomography in assessing cutaneous cancer margins of the face. Materials and Methods The excised tissue specimens that were examined, in this study, were acquired from 70 patients with 70 facial cancer lesions, with no nodal disease. Forty lesions were basal cell carcinomas (150 margins; 27 tumour positive) and ...

      Read Full Article
    15. Machine learning, imaging technique may boost colon cancer diagnosis

      Machine learning, imaging technique may boost colon cancer diagnosis

      Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal. Current colon cancer screening is performed by flexible colonoscopy. The procedure involves visual inspection of the mucosal lining of the colon and rectum with a camera mounted on an endoscope. Abnormal appearing areas are then biopsied for analysis. Although this is the current standard of ...

      Read Full Article
    16. Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography

      Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography

      Background Currently, positive margins at lumpectomy contribute to health care cost, patient anxiety, and treatment delay. Multiple technology solutions are being explored with the aim of lowering re‐excision rates for breast‐conserving surgery (BCS). We examined wide‐field optical coherence tomography (WF‐OCT), an innovative adjunct intraoperative imaging tool for tissue visualization of margins. Methods This IRB‐approved pilot study included women with invasive or in situ carcinoma scheduled for primary BCS. Lumpectomy specimens and any final/revised margins were imaged by optical coherence tomography immediately prior to standard histological processing. The optical coherence tomography used provided two‐dimensional ...

      Read Full Article
    17. Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques. The IHU-SPECTRA research unit, entirely dedicated to the development of fluorescence-guided surgery, was set up to test several innovations as part of a large-scale project (ELIOS: Endoscopic Luminescent Imaging for Precision Oncology Surgery), funded by the ARC Foundation for Cancer Research. The proposed research protocol is part of the ELIOS project and targets in particular colon tumours. The Holy Grail in oncology surgery is the radical removal of cancer cells in order to reduce the rate of tumour recurrences and increase ...

      Read Full Article
      Mentions: LLTech
    18. Analysis of low-scattering regions in optical coherence tomography

      Analysis of low-scattering regions in optical coherence tomography

      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering biological structures of interest. In a human tumor xenograft murine model, we show that these correspond to lymphatic vessels and nerves; extensive histopathologic validation studies are reported to unequivocally establish ...

      Read Full Article
    19. Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method

      Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method

      Background The purpose of this study was to develop a deep learning classification approach to distinguish cancerous from noncancerous regions within optical coherence tomography (OCT) images of breast tissue for potential use in an intraoperative setting for margin assessment. Methods A custom ultrahigh-resolution OCT (UHR-OCT) system with an axial resolution of 2.7 μm and a lateral resolution of 5.5 μm was used in this study. The algorithm used an A-scan-based classification scheme and the convolutional neural network (CNN) was implemented using an 11-layer architecture consisting of serial 3 × 3 convolution kernels. Four tissue types were classified, including adipose ...

      Read Full Article
    20. Corneal graphite deposit on anterior segment optical coherence tomography

      Corneal graphite deposit on anterior segment optical coherence tomography

      Retained intraocular graphite foreign bodies are uncommon and generally remain inert in the eye. A 16-year-old girl complained of a black spot on her right eye since 3 months following pencil tip trauma. Examination revealed a subconjunctival greyish-black nodular mass with a metallic sheen on the 5 O' clock limbus with involvement of the adjacent corneal stroma and endothelium [Figure 1] a. Optical coherence tomography revealed subconjunctival [ [Figure 1] b arrow], corneal stromal, and endothelial [ [Figure 1] b arrowhead] hyporeflective material with intense backshadowing. This visual impression will help differentiate pigmented conjunctivo--corneal lesion from other reported mimickers such as melanoma ...

      Read Full Article
    21. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the cell line HCT116. The spheroid RIs are compared to study the effect of growth time. To improve confocal microscopy imaging protocols, two immersion media (glycerol and ScaleView-A2) matching the spheroid ...

      Read Full Article
    22. Toward an All-Optical Biopsy

      Toward an All-Optical Biopsy

      Combining multiple photonic imaging techniques could allow for new, noninvasive approaches to tumor detection and assessment, meeting clinical challenges at a time of rising global cancer incidence. [Getty Images] A compact experimental setup for multimodal nonlinear microscopy in clinical settings. [Leibniz-IPHT, S. Döring] Aging populations, exposure to environmental contamination in developing countries, and other factors are driving significant increases in cancer worldwide. The World Health Organization estimates that globally, the number of cancer cases will reach 21.6 million by 2030, nearly double the 14 million patients in 2012. In Germany alone, malignant tumors are responsible for a quarter ...

      Read Full Article
    23. Melanoma Blood Vessel Changes Detected with OCT Imaging

      Melanoma Blood Vessel Changes Detected with OCT Imaging

      An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...

      Read Full Article
    24. Optical probe at surgeon's fingertips for breast cancer removal

      Optical probe at surgeon's fingertips for breast cancer removal

      A finger-mounted probe is under development at the University of Western Australia to improve the surgical removal of breast cancer. This approach could be of value in scenarios where the use of a relatively bulky handheld probe is not convenient, such as when assessing if residual tumor is present in small cavities following excision of the main tumor mass in breast-conserving surgery. The device might also prove useful for brain and liver surgery and other types of cancer. A fiber probe incorporated into a wearable thimble uses quantitative micro-elastography (QME) to translate the The finger-mounted probe is placed perpendicular to ...

      Read Full Article
    1-24 of 621 1 2 3 4 ... 24 25 26 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) University of São Paulo
    2. (1 articles) University of Toronto
  4. People in the News

    1. (1 articles) Brian C. Wilson
    2. (1 articles) I. Alex Vitkin
  5. OCT Companies in the News

    1. (1 articles) LLTech