1. Articles in category: Urology

    1-24 of 127 1 2 3 4 5 6 »
    1. Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

      Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

      We present first quantitative three-dimensional (3D) data sets recorded using optical coherence elastography (OCE) for the diagnosis and detection of prostate cancer (PCa). 120 transrectal ultrasound guided prostate biopsy specimens from 10 men suspected with prostate cancer were imaged using OCE. 3D quantitative mechanical assessment of biopsy specimens obtained in kilopascals (kPa) at an interval of 40 µm was compared with histopathology. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE in comparison to histopathology. The results show OCE imaging could reliably differentiate between benign prostate tissue, acinar atypical hyperplasia, prostatic intraepithelial neoplasia and malignant PCa. The ...

      Read Full Article
    2. Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Since it was first used to evaluate human genitourinary tissue in 1997, OCT has emerged as a promising modality to provide real-time, high-resolution imaging of urologic organs. In the bladder, it has demonstrated a high sensitivity in identifying regions of the bladder suspicious for CIS and between invasive and noninvasive malignancy; it has been studied as an “optical biopsy” both during the initial cystoscopic diagnosis and intraoperatively in bladder-preserving surgery. Several small, ex vivo studies have shown promising results in the ability of OCT to demonstrate histopathologic alterations to renal morphology such as in renal ischemia and malignancy. It may ...

      Read Full Article
    3. Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      The current diagnostic standard for grading and staging of non-muscle-invasive bladder cancer (NMIBC) is based on the histopathology obtained during transurethral resection of the bladder tumour (TURBT) or biopsies. Although considered reference standard, this technique has some limitations: First, no real-time intraoperative histological information is obtained on stage and grade. Real-time intraoperative histological information could be helpful when NMIBC is treated by electric coagulation or laser ablation. The urologist has to rely on his/her judgement of stage and grade since no tissue is harvested for histological confirmation. In addition, in many centres, patients with a history of low-grade, non-invasive ...

      Read Full Article
    4. Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

      Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

      The maintenance of urinary bladder elasticity is essential to its functions, including the storage and voiding phases of the micturition cycle. The bladder stiffness can be changed by various pathophysiological conditions. Quantitative measurement of bladder elasticity is an essential step toward understanding various urinary bladder disease processes and improving patient care. As a nondestructive, and noncontact method, laser-induced surface acoustic waves (SAWs) can accurately characterize the elastic properties of different layers of organs such as the urinary bladder. This initial investigation evaluates the feasibility of a noncontact, all-optical method of generating and measuring the elasticity of the urinary bladder. Quantitative ...

      Read Full Article
    5. Video Interview on Optical coherence tomography as a tool for in vivo staging and grading of upper urinary tract urothelial cell carcinoma: Comparison with biopsies and histopathology of the resected specimen

      Video Interview on Optical coherence tomography as a tool for in vivo staging and grading of upper urinary tract urothelial cell carcinoma: Comparison with biopsies and histopathology of the resected specimen

      Introduction and Objectives: Optical Coherence Tomography (OCT) has potential to provide real-time information on UUT-UC grade and stage. In this study we compare a) biopsy and b) OCT with gold standard histopathology of the resected specimen (HRS) for grading and staging of low- and high-grade UUT-UC. Methods: 16 patients with UUT-UC underwent diagnostic URS, including OCT and biopsy of places with visible tumour. The 2.7 Fr OCT probe was delivered through the ureteroscopes work channel. Subsequently biopsy was performed. At a later stage, patients underwent nephroureterectomy. For staging by OCT, in-house developed protocols were used and visible lesions were ...

      Read Full Article
    6. Clinical, ureteroscopic and photodynamic diagnosis of urothelial carcinomas of the upper tract: State-of-the art for the yearly scientific report of the French national association of urology

      Clinical, ureteroscopic and photodynamic diagnosis of urothelial carcinomas of the upper tract: State-of-the art for the yearly scientific report of the French national association of urology

      Purpose To propose a state-of-the art of current knowledge about clinical, ureteroscopic and photodynamic for the diagnosis of the upper urinary tract cancer (UTUC). Material and method A systematic review of the literature search was performed from the database Medline (NLM, Pubmed), focused on the following keywords: urothelial carcinomas; upper urinary tract; ureter; renal pelvis; diagnosis; fluorescence; ureteroscopy; photodynamic technique; biopsy; cytology. Results Gross hematuria and flank pain are the two main clinical symptoms revealing a UTUC in daily clinical practice. Urinary cystoscopy and cystoscopy are mandatory to rule out a concomittant synchronous bladder tumour. Flexible ureteroscopy has revolutionized the ...

      Read Full Article
    7. Optical diagnostics for Upper Urinary Tract Urothelial cancer: technology, thresholds and clinical applications

      Optical diagnostics for Upper Urinary Tract Urothelial cancer: technology, thresholds and clinical applications

      Purpose: Developments in optical diagnostics have potential for less invasive diagnose of upper urinary tract urothelial carcinoma (UUT-UC). This systematic review provides an overview of technology, applications and limitations of recently developed optical diagnostics in the upper urinary tract and outlines their potential for future clinical applications. In addition, current evidence was evaluated. Literature search: A PubMed literature search was performed and papers on Narrow Band Imaging (NBI), Photodynamic Diagnosis (PDD), Storz Professional Imaging Enhancement System (SPIES), Optical Coherence Tomography (OCT) and Confocal Laser Endomicroscopy (CLE) regarding UUT-UC were reviewed for data extraction. Study quality was reviewed according to QUADAS ...

      Read Full Article
    8. Novel endoscopic diagnosis for bladder cancer

      Novel endoscopic diagnosis for bladder cancer

      A dvances in endoscopic imaging technology may improve sensitivity for the detection of bladder cancer and provide a more complete understanding of the urothelial landscape, and it also may lead to improved short-term and long-term cancer control. Fluorescence cystoscopy requires intravesical administration of a photosensitizing agent (5-aminolevulinic acid or hexaminolevulinate), and imaging with a blue-light endoscopy system demonstrably improves the detection of papillary and flat bladder lesions compared with conventional white-light cystoscopy. Prospective phase 3 clinical trials have demonstrated improved diagnostic ability, enhanced tumor resection, and a small but significant reduction in recurrence-free survival. Optical coherence tomography delineates subsurface microarchitecture ...

      Read Full Article
    9. New imaging techniques for nonmuscle invasive bladder cancer

      New imaging techniques for nonmuscle invasive bladder cancer

      Purpose of review: Recent advances in imaging techniques provide innovative tools for the detection of bladder cancer. In patients with nonmuscle invasive cancer, there is a need for enhanced visualization of flat growing lesions and multifocal tumors. The aim of new imaging modalities is the improved detection and staging of bladder lesions, as an adjunct to conventional white light endoscopy. Recent findings: Fluorescence cystoscopy with 5-aminolevulinic acid and hexaminolevulinate has been shown to improve the detection of papillary and flat bladder lesions in comparison to conventional white light cystoscopy. Prospective phase III clinical trials have demonstrated advanced diagnostic ability, enhanced ...

      Read Full Article
    10. Mannitol Infusion Within 15 Min of Cross-Clamp Improves Living Donor Kidney Preservation

      Mannitol Infusion Within 15 Min of Cross-Clamp Improves Living Donor Kidney Preservation

      BACKGROUND: Optical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period of ischemia experienced between the time of arterial vessel clamping and flushing the excised kidney with cold preservation solution. Damage to the tubules as a result of this cell swelling resulted in varying degrees of acute tubular necrosis (ATN) that slowed the recovery of the donor kidneys during the first 2 weeks after their transplantation. METHODS: To prevent this cell damage during LDK procurement, we changed the protocol for intravenous ...

      Read Full Article
    11. Optical Coherence Tomography (OCT) in Hypertension & Chronic Kidney Disease (CKD)

      Optical Coherence Tomography (OCT) in Hypertension & Chronic Kidney Disease (CKD)

      Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes. Part of this risk is due to changes in the structure and function of the blood vessels throughout the body. It is thought that reducing high blood pressure and treating chronic kidney disease improves the structure and function of blood vessels but information on this is limited. Optical coherence tomography (OCT) is a method of looking at the blood vessels at the back of the eye. It is a simple, quick and non-invasive test that you may have previously ...

      Read Full Article
    12. Georgetown University Receives NIH Grant for Non-Invasive Evaluation of Transplant Kidney Using OCT

      Georgetown University Receives NIH Grant for Non-Invasive Evaluation of Transplant Kidney Using OCT

      Georgetown University Received at 2014 NIH Grant for $520,754 for Non-Invasive Evaluation of Transplant Kidney Using OCT. The principal investigator is Peter Michael Andrewss. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. There is currently a worldwide shortage of kidneys for transplantation due mainly to the fact that there is no reliable means to determine their viability (i.e., kidneys stored for long periods of time, etc.). Also, following transplantation, kidneys oftn do not function immediately and their status is unclear. Previously, we have shown that the histopathology of living ...

      Read Full Article
    13. Optical Coherence Tomography in Staging Patients With Upper Tract Urothelial Cancer

      Optical Coherence Tomography in Staging Patients With Upper Tract Urothelial Cancer

      This clinical trial studies how well optical coherence tomography works in staging patients with upper-tract urothelial carcinomas. Staging describes the severity of a person's cancer based on the size and/or extent (reach) of the original (primary) tumor and whether or not cancer has spread in the body. It also helps the doctor plan the appropriate treatment. Optical coherence tomography is a procedure that uses infrared light waves to give three-dimensional pictures of structures inside tissues and organs. The pictures are made by a computer linked to the light source. Optical coherence tomography may be effective in staging patients ...

      Read Full Article
    14. Emerging endoscopic imaging technologies for bladder cancer detection

      Emerging endoscopic imaging technologies for bladder cancer detection

      Modern urologic endoscopy is the result of continuous innovations since the early nineteenth century. White-light cystoscopy is the primary strategy for identification, resection, and local staging of bladder cancer. While highly effective, white light cystoscopy has several well-recognized shortcomings. Recent advances in optical imaging technologies and device miniaturization hold the potential to improve bladder cancer diagnosis and resection. Photodynamic diagnosis and narrow band imaging are the first to enter the clinical arena. Confocal laser endomicroscopy, optical coherence tomography, Raman spectroscopy, UV autofluorescence, and others have shown promising clinical and pre-clinical feasibility. We review their mechanisms of action, highlight their respective ...

      Read Full Article
    15. Clinical applications of functional optical coherence tomography (Thesis)

      Clinical applications of functional optical coherence tomography (Thesis)

      The purpose of the work presented in this thesis is to show the potential of functional optical coherence tomography (OCT) to discriminate pathological from normal tissues in several clinical settings, by means of the attenuation coefficient. To that end, several fundamental studies were carried out to increase the fundamental understanding of the measured signals (in phantoms, during apoptosis) and both ex and in vivo investigations are performed in the urological and gynecological clinic.

      Read Full Article
    16. Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

      Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

      We describe a combination of fabrication techniques and a general process to construct a three-dimensional (3-D) phantom that mimics the size, macroscale structure, microscale surface topology, subsurface microstructure, optical properties, and functional characteristics of a cancerous bladder. The phantom also includes features that are recognizable in white light (i.e., the visual appearance of blood vessels), making it suitable to emulate the bladder for emerging white light + optical coherence tomography (OCT) cystoscopies and other endoscopic procedures of large, irregularly shaped organs. The fabrication process has broad applicability and can be generalized to OCT phantoms for other tissue types or phantoms ...

      Read Full Article
    17. Volumetric mosaicing for optical coherence tomography for large area bladder wall visualization

      Volumetric mosaicing for optical coherence tomography for large area bladder wall visualization

      Optical coherence tomography (OCT) has shown potential as a complementary imaging modality to white light cystoscopy (WLC) because it can visualize sub-surface details of the bladder wall, enabling it to stage early cancers and visualize tumors undetectable to WLC. However, the inherently small field of view (FOV) of OCT compared with the area of the bladder wall restricts its clinical utility. A large OCT FOV could improve surgical planning by enabling complete visualization of tumor margins or could aid in early cancer detection by tracking the appearance of the bladder wall over time. To overcome the limited FOV of OCT ...

      Read Full Article
    18. Multilayered disease-mimicking bladder phantom with realistic surface topology for optical coherence tomography

      Multilayered disease-mimicking bladder phantom with realistic surface topology for optical coherence tomography

      Optical coherence tomography (OCT) has shown potential as a complementary modality to white light cystoscopy (WLC), the gold standard for imaging bladder cancer. OCT can visualize sub-surface details of the bladder wall, which enables it to stage cancers and detect tumors that are otherwise invisible to WLC. Currently, OCT systems have too slow a speed and too small a field of view for comprehensive bladder imaging, which limits its clinical utility. Validation and feasibility testing of technological refinements aimed to provide faster imaging and wider fields of view necessitates a realistic bladder phantom. We present a novel process to fabricate ...

      Read Full Article
    19. Non-Invasive Evaluation of Transplant Kidney Using OCT

      Non-Invasive Evaluation of Transplant Kidney Using OCT

      Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can function as a type of "optical biopsy", providing non-invasive cross-sectional images of tissue architectural morphology in situ and in real-time. This proposal will demonstrate that OCT has the ability to provide novel and valuable histopathological information regarding donor kidneys that can be used to predict post-transplant renal function. These investigations will result in a major breakthrough in increasing the number of healthy kidneys available for transplantation by making the most efficient use of available donor kidneys, eliminating the possible use of bad donor kidneys, providing an accurate measure ...

      Read Full Article
    20. Optical coherence tomography provides images similar to histology and allows the performance of extensive measurements of drug-eluting metal stents in animal ureter

      Optical coherence tomography provides images similar to histology and allows the performance of extensive measurements of drug-eluting metal stents in animal ureter

      Optical coherence tomography (OCT) images and histology images of metal stents (MSs) inserted in animal ureters were compared, and the reliability of an OCT-based automated method for the performance of quantitative evaluation of ureteral MSs was evaluated. A zotarolimus-eluting metal stent (ZES) and a bare metal stent (BMS) were inserted in each ureter of ten pigs and six rabbits. OCT was performed in unobstructed stented ureters. Histopathologic examination of the stented ureters embedded in glycol-methacrylate took place. Quadrants of OCT images were compared to their respective histologic images by employing two independent observers who delineated different layers in the quadrants ...

      Read Full Article
    21. Using Optical Coherence Tomography (OCT) to Evaluate Human Donor Kidneys Prior to and Following Transplantation

      Using Optical Coherence Tomography (OCT) to Evaluate Human Donor Kidneys Prior to and Following Transplantation

      The most common insult to donor kidneys destined for transplantation is Acute Tubular Necrosis (ATN). The extent of ATN will affect post-transplant function and is a significant risk factor for long-term graft function and survival. Optical Coherence Tomography (OCT) is a rapidly emerging imaging modality that can function as a type of “optical biopsy”, providing non-invasive images of tissue morphology in situ and in real-time. In this paper, we review studies that support the use of OCT and Doppler based OCT (i.e., DOCT) to image the renal microstructure and blood flow of human donor kidneys. We conclude that OCT ...

      Read Full Article
    22. Optical coherence tomography diagnostics for onco–urology. Review of clinical perspectives

      Optical coherence tomography diagnostics for onco–urology. Review of clinical perspectives

      Introduction. Optical coherence tomography (OCT) is being investigated widely for use in urologic pathology. The current imaging of urogenital cancers cannot be perfect, thus, routine methods demands new updates or inventions of alternative radiological scope. OCT presents so–called “live” optical biopsy. The authors aim to review this modality for uro–oncological purposes. Matherial and methods. A series of 37 publications between 1989 and 2012 was selected and cited from GoogleScholar and PubMED/MEDLINE. The urogenital tract (bladder, ureter, scrotum organs and prostate) was imaged by OCT. Results. The overall OCT sensitivity, specificity, accuracy, negative and positive predictive values ranged ...

      Read Full Article
    23. From industrial laboratory directly to operating table: the vicissitudes of optical coherence tomography (OCT)

      From industrial laboratory directly to operating table: the vicissitudes of optical coherence tomography (OCT)

      The current issue of the CEJU runs a paper presenting the prospect of an amazing, unconventional diagnostic method. Optical coherence tomography (OCT) is a relatively new interferometric technique of optical imaging [1]. Though physical foundations of OCT are difficult to grasp for a run–of–the–mill kind of CEJU reader (editor alike), Dr. S. Kharchenko and co–workers’ paper deserves our notice. This technique has been developed in the Massachusetts Institute of Technology twenty years ago and now OCT emerges as a powerful supplementary tool for uro–oncology. We can be really moved by amazing 3–D scans of ...

      Read Full Article
    24. Optical Coherence Tomography of the Living Human Kidney

      Optical Coherence Tomography of the Living Human Kidney

      Acute tubular necrosis (ATN) induced by ischemia is the most common insult to donor kidneys destined for transplantation. ATN results from swelling and subsequent damage to cells lining the kidney tubules. In this study, we demonstrate the capability of optical coherence tomography (OCT) to image the renal microstructures of living human donor kidneys and potentially provide a measure to determine the extent of ATN. We also found that Doppler-based OCT (i.e., DOCT) reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal function. All OCT/DOCT observations were performed in a noninvasive, sterile ...

      Read Full Article
    1-24 of 127 1 2 3 4 5 6 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) Academic Medical Center at the University of Amsterdam
    2. (1 articles) University of Florida
    3. (1 articles) University of Washington
  4. People in the News

    1. (1 articles) Ruikang K. Wang
    2. (1 articles) Chunhui Li
    3. (1 articles) Li-Ming Su
    4. (1 articles) Jean J. M. C. H. de la Rosette
    5. (1 articles) Daniël M. de Bruin
    6. (1 articles) Mieke T. J. Bus
    7. (1 articles) Theo M. de Reijke
  5. OCT Products in the News

    1. (1 articles) Imalux Niris