1. Articles in category: Urology

    1-24 of 184 1 2 3 4 5 6 7 8 »
    1. Toward image quality assessment in optical coherence tomography (OCT) of rat kidney

      Toward image quality assessment in optical coherence tomography (OCT) of rat kidney

      Background Optical coherence tomography (OCT) is a useful tool for the evaluation of structure and function of the kidney, but the image quality can be affected by many factors. Objective The objective of this study was to assess the image quality of different OCT systems in OCT imaging of the living kidney. Methods One swept-source OCT (SSOCT) of 1300 nm, one spectral domain OCT (SDOCT) of 1300 nm and another of 900 nm were used. A FeO phantom was used to establish the point spread function (PSF). Rat kidneys were imaged for image quality assessment. Light penetration in the kidney ...

      Read Full Article
    2. The analysis of prostate tissue by optical coherence tomography (Thesis)

      The analysis of prostate tissue by optical coherence tomography (Thesis)

      The prostate is the gland located around the urethra beneath the bladder that produces most of the sperm fluid (figure 1). Prostate cancer (PCa) accounted for almost 1 in 5 new cancer diagnoses in males in the USA in 2017, and 1 in 8 men will develop invasive cancer in the prostate in their lifetime [1]. Prostate cancer is the second most common cancer in men (after skin cancer) and the second most common cause of cancer-related death (after lung cancer). Advances in screening, diagnosis, and treatment have led to an overall survival increase from 69% in 1991-1995 to 89 ...

      Read Full Article
    3. Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

      Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

      Objective: To systematically evaluate the diagnostic efficacy of confocal laser endomicroscopy (CLE) in detection of bladder cancer. Methods: A systematic literature search on CLE in diagnosing bladder cancer in PubMed, Embase, and the Cochrane Library databases was performed. A bivariate meta-regression model was used for meta-analysis to evaluate the pooled diagnostic value of CLE. Results: A total of 5 eligible studies involving 302 lesions were available for this meta-analysis. In a per-lesion analysis, pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver-operating curve (SROC) area under the curve (AUC) of CLE ...

      Read Full Article
      Mentions: Fudan University
    4. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and their associated cardiovascular disease. Homology between the eye and the kidney suggests that noninvasive imaging of the retinal vessels can detect these microvascular alterations to improve targeting of at-risk patients ...

      Read Full Article
    5. En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      The increase histopathological evaluation of prostatectomy specimens rises the workload on pathologists. Automated histopathology systems, preferably directly on unstained specimens, would accelerate the pathology workflow. In this study, we investigate the potential of quantitative analysis of Optical Coherence Tomography (OCT) to separate benign from malignant prostate tissue automatically. Twenty fixated prostates were cut, from which 54 slices were scanned by OCT. Quantitative OCT metrics (attenuation coefficient, residue, goodness‐of‐fit) were compared for different tissue types, annotated on the histology slides. To avoid misclassification, the poor‐quality slides, and edges of annotations were excluded. Accurate registration of OCT data with ...

      Read Full Article
    6. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm to the patient. Nowadays, optical modalities, such as optical coherence tomography (OCT) and Raman spectroscopy (RS), have proven to detect cancer in real time and can provide more detailed clinical ...

      Read Full Article
    7. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Context.— The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) has had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (μOCT) that generates depth-resolved tissue images at a high frame rate with an isotropic resolution of 1 μm. Objective.— To demonstrate that optical images obtained with μOCT provide cellular-level contrast in prostate specimens ...

      Read Full Article
    8. Diagnostic accuracy of optical coherence tomography for the diagnosis of bladder cancer: A systematic review and meta-analysis

      Diagnostic accuracy of optical coherence tomography for the diagnosis of bladder cancer: A systematic review and meta-analysis

      Background Bladder cancer is the fourth most common malignancy in men and a considerable disease burden globally. Multiple studies have focused on the accuracy of optical coherence tomography for bladder cancer diagnosis; however, the findings are inconsistent. Here, we assessed the accuracy of optical coherence tomography for bladder cancer diagnosis. Methods Embase, PubMed, Medline, Web of Science, and the Cochrane Library database were searched for relevant studies from the earliest date available through March 11, 2019. Studies evaluating the accuracy of optical coherence tomography bladder cancer diagnosis were included. Pooled sensitivity, specificity, and area under the curve values of weighted ...

      Read Full Article
    9. The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology ...

      Read Full Article
    10. Apelin as a Potential Treatment for Chronic Kidney Disease

      Apelin as a Potential Treatment for Chronic Kidney Disease

      Chronic kidney disease (CKD) affects 8-16% of the world's population, and is independently associated with cardiovascular disease (CVD). As renal function declines, rates of major adverse cardiovascular events, cardiovascular and all-cause mortality increase. In addition to hypertension, increased arterial stiffness is characteristic of CKD, a marker of CVD risk, and an independent predictor of mortality in CKD patients. The endothelium is an important regulator of arterial stiffness, and endothelial dysfunction is a feature of CKD and a predictor of CVD. Current treatment of CKD is limited and aims to reduce blood pressure and proteinuria through the use of angiotensin ...

      Read Full Article
    11. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Context.— The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) have had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (μOCT) that generates depth-resolved tissue images at a high frame rate with an isotropic resolution of 1 μm. Objective.— To demonstrate that optical images obtained with μOCT provide cellular-level contrast in prostate specimens ...

      Read Full Article
    12. Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

      Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

      Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT in humans up to December 2017. Reviews were excluded. Case reports were excluded, unless they presented a landmark in the development of OCT. Results Out of 878 articles, 17 relevant ...

      Read Full Article
    13. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder wall for suspicious lesions with the ability to discriminate malignant tissue from healthy urothelium. Upon identification of degenerated tissue via OCT, RS was implemented to determine the molecular characteristics via ...

      Read Full Article
    14. One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

      One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

      Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study is to validate a registration method of quantitative OCT parameters to histological tissue outcome through one‐to‐one registration of OCT with histology. We matched OCT images of unstained fixated ...

      Read Full Article
    15. Focal Prostate Imaging With CLE and OCT (FPI)

      Focal Prostate Imaging With CLE and OCT (FPI)

      The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging modalities with potential for in-vivo prostate imaging. The investigators anticipate that integrating focal imaging with MRI/TRUS fusion will further improve prostate cancer detection and provides a real-time histopathological threedimensional representation of the tumor lesions. This is an investigator-initiated, prospective in-vivo safety and feasibility study with transperineal template mapping biopsies (TTMB) and two focal imaging methods, CLE and OCT, in prostate tissue.

      Read Full Article
    16. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. Objective: This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of ...

      Read Full Article
    17. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound

      Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound

      Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA®) was used for reconstruction and coregistration of CT, OCT, and ELUS. Finally, CT was used to obtain exact probe localization. Coregistered OCT and ELUS datasets were compared with histology. Coregistration with three-dimensional ...

      Read Full Article
    18. Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

      Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

      Prostate cancer (PCa) is a heterogeneous disease with multifocal origin. In current clinical care, the Gleason scoring system is the well-established diagnosis by microscopic evaluation of the tissue from trans-rectal ultrasound (TRUS) guided biopsies. Nevertheless, the sensitivity and specificity in detecting PCa can range from 40 to 50% for conventional TRUS B-mode imaging. Tissue elasticity is associated with the disease progression and elastography technique has recently shown promise in aiding PCa diagnosis. However, many cancer foci in the prostate gland has very small size less than 1 mm and those detected by medical elastography were larger than 2 mm. Hereby ...

      Read Full Article
    19. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

      Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

      Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney microstructures in vivo without administering exogenous contrast agents. A murine model of CKD induced by intravenous Adriamycin (ADR) injection is evaluated by OCT. OCT images of the rat kidneys have ...

      Read Full Article
    20. Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe

      Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe

      Objective To assess the use of a handheld optical coherence tomography (OCT) probe for the evaluation of intraoperative surgical margins during partial nephrectomy (PN). Methods In an initial feasibility study, a radical nephrectomy specimen with a 9-cm tumor was cut into 19 sections, exposing 0 mm (n=8), 1 mm (n=6), and 2 mm (n=5) gross margins. OCT was used to determine the margin width in each specimen. Second, a prospective ex vivo assessment of 15 PN tumor specimens was performed with OCT to determine margin status and to measure the attenuation coefficient (AC) of tumor and renal ...

      Read Full Article
    21. Dutch Health-Care Startup Scinvivo to present at DMD 2017 Europe on "Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter"

      Dutch Health-Care Startup Scinvivo to present at DMD 2017 Europe on "Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter"

      Scinvivo talk, entitled ‘ Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter’, has been selected for a presentation at the Design of Medical Devices Europe Conference 2017 (DMD Europe 2017)! The central theme of this year’s conference is microfabrication for medical devices. More information about the conference can be found at: https://dmd2017.eu/ . Scinvivo will present on Tuesday November the 14 th , at 11:30u in The Strip Conference centre.

      Read Full Article
      Mentions: Scinvivo
    22. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images

      Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images

      Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract: Kidney ischemia-reperfusion (I/R) accounts for the majority of acute kidney injury cases, whose consequences are commonly encountered after kidney transplantation. Optical coherence tomography (OCT) has been applied to image ...

      Read Full Article
    23. Apparatus and methods for non-invasive assessment of transplant kidney viability

      Apparatus and methods for non-invasive assessment of transplant kidney viability

      A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire ...

      Read Full Article
    24. Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy

      Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy

      Context With more complex kidney tumors treated by nephron-sparing surgery (NSS), complete tumor resection is becoming increasingly challenging. Intraoperative imaging may improve the establishment of negative surgical margins. Objective To discuss intraoperative imaging techniques that may help achieve complete tumor resection in NSS of renal tumors. Evidence acquisition PubMed was searched for English articles on intraoperative imaging during NSS of renal cell carcinoma published after 2005, and a reference search of retrieved articles was performed. Evidence synthesis Included studies reported about ultrasonography, fluorescence imaging, augmented reality, optical coherence tomography, and ex vivo magnetic resonance imaging (MRI). The number of patients ...

      Read Full Article
    1-24 of 184 1 2 3 4 5 6 7 8 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) University of Colorado
    2. (1 articles) Fujian Normal University