Urology -Optical Coherence Tomography News

Articles in category: Urology

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1. Focal Prostate Imaging With CLE and OCT (FPI)
  
  Explore Home - ClinicalTrials.gov May 22 2018 Urology , Clinical Trials
  
  The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging modalities with potential for in-vivo prostate imaging. The investigators anticipate that integrating focal imaging with MRI/TRUS fusion will further improve prostate cancer detection and provides a real-time histopathological threedimensional representation of the tumor lesions. This is an investigator-initiated, prospective in-vivo safety and feasibility study with transperineal template mapping biopsies (TTMB) and two focal imaging methods, CLE and OCT, in prostate tissue.
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  Mentions: Academic Medical Center at the University of Amsterdam Jean J. M. C. H. de la Rosette
2. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
  
  Explore JRP-JMIR Research Protocols May 22 2018 Urology
  
  Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. Objective: This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
3. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound
  
  Explore SPIE Digital Library Feb 17 2018 Urology
  
  Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA®) was used for reconstruction and coregistration of CT, OCT, and ELUS. Finally, CT was used to obtain exact probe localization. Coregistered OCT and ELUS datasets were compared with histology. Coregistration with three-dimensional ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
4. Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography
  
  Explore SPIE Digital Library Feb 13 2018 Urology
  
  Prostate cancer (PCa) is a heterogeneous disease with multifocal origin. In current clinical care, the Gleason scoring system is the well-established diagnosis by microscopic evaluation of the tissue from trans-rectal ultrasound (TRUS) guided biopsies. Nevertheless, the sensitivity and specificity in detecting PCa can range from 40 to 50% for conventional TRUS B-mode imaging. Tissue elasticity is associated with the disease progression and elastography technique has recently shown promise in aiding PCa diagnosis. However, many cancer foci in the prostate gland has very small size less than 1 mm and those detected by medical elastography were larger than 2 mm. Hereby ...
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  Mentions: Chunhui Li Ghulam Nabi University of Dundee
5. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
  
  Explore SPIE Digital Library Dec 5 2017 Urology
  
  Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney microstructures in vivo without administering exogenous contrast agents. A murine model of CKD induced by intravenous Adriamycin (ADR) injection is evaluated by OCT. OCT images of the rat kidneys have ...
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  Mentions: University of Maryland Yu Chen
6. Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe
  
  Explore Urology Nov 29 2017 Urology
  
  Objective To assess the use of a handheld optical coherence tomography (OCT) probe for the evaluation of intraoperative surgical margins during partial nephrectomy (PN). Methods In an initial feasibility study, a radical nephrectomy specimen with a 9-cm tumor was cut into 19 sections, exposing 0 mm (n=8), 1 mm (n=6), and 2 mm (n=5) gross margins. OCT was used to determine the margin width in each specimen. Second, a prospective ex vivo assessment of 15 PN tumor specimens was performed with OCT to determine margin status and to measure the attenuation coefficient (AC) of tumor and renal ...
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7. Dutch Health-Care Startup Scinvivo to present at DMD 2017 Europe on "Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter"
  
  Explore Optical Coherence Tomography News Nov 17 2017 Urology
  
  Scinvivo talk, entitled ‘ Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter’, has been selected for a presentation at the Design of Medical Devices Europe Conference 2017 (DMD Europe 2017)! The central theme of this year’s conference is microfabrication for medical devices. More information about the conference can be found at: https://dmd2017.eu/ . Scinvivo will present on Tuesday November the 14 th , at 11:30u in The Strip Conference centre.
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  Mentions: Scinvivo
8. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images
  
  Explore IEEE Xplore Nov 15 2017 Urology
  
  Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract: Kidney ischemia-reperfusion (I/R) accounts for the majority of acute kidney injury cases, whose consequences are commonly encountered after kidney transplantation. Optical coherence tomography (OCT) has been applied to image ...
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  Mentions: University of Maryland Yu Chen
9. Apparatus and methods for non-invasive assessment of transplant kidney viability
  
  Explore uspto.gov Aug 22 2017 Urology , Patents
  
  A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire ...
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  Mentions: University of Maryland Yu Chen Georgetown University
10. Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy
  
  Explore European Urology Focus May 18 2017 Urology
  
  Context With more complex kidney tumors treated by nephron-sparing surgery (NSS), complete tumor resection is becoming increasingly challenging. Intraoperative imaging may improve the establishment of negative surgical margins. Objective To discuss intraoperative imaging techniques that may help achieve complete tumor resection in NSS of renal tumors. Evidence acquisition PubMed was searched for English articles on intraoperative imaging during NSS of renal cell carcinoma published after 2005, and a reference search of retrieved articles was performed. Evidence synthesis Included studies reported about ultrasonography, fluorescence imaging, augmented reality, optical coherence tomography, and ex vivo magnetic resonance imaging (MRI). The number of patients ...
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11. Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy
  
  Explore Журнал СТМ Apr 18 2017 Urology
  
  The aim of the study is to demonstrate the potential of cross-polarization optical coherence tomography (CP OCT) as a minimally invasive real-time technique for detection of bladder cancer against a background of severe inflammation. Materials and Methods. For the verification of CP OCT diagnostic data related to the condition of collagen comparison with high-resolution microscopy inspection was performed and correlation of the results was calculated. The CP OCT study was performed on samples of tissue with muscle-invasive urothelial carcinoma T 2–3 N 0–х M 0 (G2, 3) in 18 patients ranging in age from 50 to 64 obtained ...
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  Mentions: Nizhny Novgorod State Medical Academy Institute of Applied Physics Natalia D. Gladkova
12. Georgetown University Receives NIH Grant for Non-Invasive Evaluation f Transplant Kidney using OCT
  
  Explore Optical Coherence Tomography News Apr 4 2017 Urology , Funding
  
  Georgetown University Receives a 2017 NIH Grant for $349,058 for Non-Invasive Evaluation f Transplant Kidney using OCT. The principal investigator is Peter Andrews. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. There is currently a worldwide shortage of kidneys for transplantation due mainly to the fact that there is no reliable means to determine their viability (i.e., kidneys stored for long periods of time, etc.). Also, following transplantation, kidneys oftn do not function immediately and their status is unclear. Previously, we have shown that the histopathology of living, superficial ...
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  Mentions: National Institutes of Health Georgetown University
13. Can we improve transurethral resection of the bladder tumour for nonmuscle invasive bladder cancer?
  
  Explore LWW Online Mar 1 2017 Oncology , Urology
  
  Purpose of review: The recurrence rate in patients with nonmuscle invasive bladder cancer is high, and the quality of transurethral resection of the bladder (TURB) tumour influences recurrence risk. We review new methods that aim to improve the effectiveness of TURB, and highlight studies of the past year. Recent findings: Several approaches have been explored: bipolar resection is well tolerated and efficient; however, surgical outcomes are not clearly superior to monopolar resection; en-bloc resection seems feasible and well tolerated, and has the potential to improve the quality of tissue for histopathology; enhancement techniques such as photodynamic diagnosis, narrow band imaging ...
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  Mentions: Theo M. de Reijke
14. Quality control and primo-diagnosis of transurethral bladder resections with full-field OCT
  
  Explore Conference Proceedings Feb 16 2017 Urology
  
  Transurethral resections are commonly used for bladder cancer diagnosis, treatment and follow-up. Cancer staging relies largely on the analysis of muscle in the resections; however, muscle presence is uncertain at the time of the resection. An extemporaneous quality control tool would be of great use to certify the presence of muscle in the resection, and potentially formulate a primo-diagnosis, in order to ensure optimum patient care. Full-field optical coherence tomography (FFOCT) offers a fast and non-destructive method of obtaining images of biological tissues at ultrahigh resolution (1μm in all 3 directions), approaching traditional histological sections. This study aimed to ...
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  Mentions: LLTech Eugénie Dalimier
15. New technologies for upper tract urothelial carcinoma management
  
  Explore LWW Online Jan 27 2017 Oncology , Urology
  
  Purpose of review: Image enhancement techniques and optical diagnostic tools have emerged in the quest to improve diagnostics and treatment in patients with upper urinary tract carcinoma (UTUC). The aim of the present report is to describe their mechanisms of action and to assess the current evidence on applicability and utility in UTUC. Recent findings: Image enhancement techniques including narrow band imaging, Image1 S, and photodynamic diagnosis aim at better visualization of malignant urothelium and especially flat tumours or carcinoma in situ which are often difficult to see with white light endoscopy. Conducted studies in the upper tract are scarce ...
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  Mentions: Academic Medical Center at the University of Amsterdam Jean J. M. C. H. de la Rosette
16. Renal fluid overload diagnosed by retinal optical coherence tomography scanning
  
  Explore sjkdt.org Dec 3 2016 Ophthalmology , Urology
  
  Fluid overload is one of the major findings in patients with end-stage renal disease. Common findings in fluid overload include shortness of breath, pedal edema, ascites, and pericardial effusion. Rarely, vision loss can be associated with decompensated systemic fluid status. In the following case, we report an unusual case of vision loss due to retinal edema as a result of fluid overload diagnosed and followed to resolution by optical coherence tomography testing.
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17. LLTECH Records Major Progress In Prostate Cancer Detection And Diagnosis On Use Its Cellular-Scale Imaging Solution
  
  Explore Optical Coherence Tomography News Oct 13 2016 Urology , Other Business News
  
  LLTech, an imaging company specialized in the field of the real-time optical biopsy for the diagnosis and the assessment of cancer surgery, announces today the publication of a new study demonstrating the potential of its Full-field optical coherence tomography (FFOCT) technology in the pre-histological detection of prostate cancer. During a study led to the Beijing Hospital of Health Ministry (Beijing, China), Cochin Hospital (Paris, France) and UCLA (Los Angeles, USA), three readers (a pathologist with previous experience with FFOCT, a pathologist new to FFOCT, and a urologist new to FFOCT) were trained to read FFOCT images of prostate biopsies (a ...
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  Mentions: UCLA LLTech Bertrand de Poly
18. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times
  
  Explore Home - Springer Aug 16 2016 Developmental Biology , Urology
  
  We observed in vivo kidney dysfunction with various ischemia times at 30, 75, 90, and 120 min using multi-modality optical imaging: optical coherence tomography (OCT), Doppler OCT (DOCT), and two-photon microscopy (TPM). We imaged the renal tubule lumens and glomerulus at several areas of each kidney before, during, and after ischemia of 5-month-old female Munich-Wistar rats. For animals with 30 and 75 min ischemia times, we observed that all areas were recovered after ischemia, that tubule lumens were re-opened and the blood flow of the glomerulus was re-established. For animals with 90 and 120 min ischemia times, we observed unrecovered ...
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  Mentions: University of Maryland Yu Chen Tianjin University
19. Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy
  
  Explore Elsevier Health Jul 29 2016 Urology
  
  Purposes Biopsies and cytology are cornerstones in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). However, a high rate of non-diagnostic biopsies, tumor upgrading and -staging after nephroureterectomy is observed. In this prospective in vivo study we aimed to evaluate the diagnostic accuracy of OCT for grading and staging of UTUC Material & Methods Twenty-six patients underwent diagnostic URS including biopsies and OCT imaging, followed by nephroureterectomy or segmental ureter resection. Sensitivity, specificity, negative predictive value and positive predictive value of UTUC grading and staging by OCT were evaluated according to the STARD initiative and second stage (2a and 2b ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
20. Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease
  
  Explore Home - Springer Jun 25 2016 Cardiology , Urology
  
  The progression of coronary atherosclerosis has been influenced by the presence of chronic kidney disease (CKD). This study investigated the impact of CKD stages on coronary plaque components observed on optical coherence tomography (OCT). We investigated 296 native coronary lesions with stable angina pectoris treated with stent implantation. All lesions were divided into the three groups according to the values of estimated glomerular filtration rate (eGFR, mL min −1 1.73 m −2 ): the non-CKD group (eGFR ≥60, n = 142), CKD group (15 ≤ eGFR < 60, n = 126), and end-stage kidney disease (ESKD) group (eGFR <15 and/or hemodialysis, n = 28 ...
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  Mentions: Tokyo Medical & Dental University Keiichi Hishikari
21. High efficiency for prostate biopsy qualification with full-field OCT after training
  
  Explore Conference Proceedings Jun 13 2016 Oncology , Urology
  
  Full-field optical coherence tomography (FFOCT) offers a fast and non-destructive method of obtaining images of biological tissues at ultrahigh resolution, approaching traditional histological sections. In the context of prostate cancer diagnosis involving multiple biopsies, FFOCT could be used to validate the cores just after they are obtained in order to guide the number of biopsies to be performed. The aim of the study was to define and test a training protocol for efficient FFOCT prostate biopsy assessment. Three readers (a pathologist with previous experience with FFOCT, a pathologist new to FFOCT, and a urologist new to FFOCT) were trained to ...
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  Mentions: UCLA LLTech Eugénie Dalimier
22. Optical Coherence Tomography of the Aging Kidney
  
  Explore ectrx.org May 5 2016 Urology
  
  Objectives: The aging kidney exhibits a progressive decline in renal function with characteristic histopathologic changes and is a risk factor for renal transplant. However, the degree to which the kidney exhibits this decline depends on several factors that vary from one individual to the next. Optical coherence tomography is an evolving noninvasive imaging technology that has recently been used to evaluate acute tubular necrosis of living-human donor kidneys before their transplant. With the increasing use of kidneys from older individuals, it is important to determine whether optical coherence tomography also can distinguish the histopathology associated with aging. Materials and Methods ...
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  Mentions: University of Maryland Yu Chen
23. Combined optical coherence tomography and optical coherence elastography for glomerulonephritis classification
  
  Explore Conference Proceedings Mar 13 2016 Urology
  
  Acute Glomerulonephritis caused by anti-glomerular basement membrane disease has a high mortality due to delayed diagnosis. Thus, an accurate and early diagnosis is critical for preserving renal function. Currently, blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution. Optical coherence tomography (OCT) is a noninvasive imaging technique that provides superior spatial resolution (micron scale) as compared to ultrasound and CT. Pathological changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signal, such as optical attenuation and speckle variance. Moreover, OCT does not rely ...
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  Mentions: University of Chicago Kirill V. Larin University of Houston
24. Catheter-based intraluminal optical coherence tomography of the normal human upper urinary tract in vivo: proof of concept and comparison with an ex-vivo porcine model
  
  Explore Home - Bladder Journal Feb 24 2016 Urology
  
  Objective : Single-slice, cross-sectional, intraluminal optical-coherence-tomography (OCT) is a new destruction-free optical imaging method that could be applied clinically to examine the upper urinary tract from within. In-vivo access to the human upper urinary tract (UUT) was attempted. Similar performance statistics as in ex-vivo porcine UUT were expected for delineation of different wall layers by in-vivo OCT of human UUTs. MATERIALS AND METHODS : Institutional ethics committee approved OCT in a volunteer sample of 15 patients suspected of having UUT pathology (urolithiasis, strictures, urothelial carcinoma (UC)). Commercially available, catheter-mounted 400-μm-OCT-probes (lateral resolution, < 20 µm) were introduced through a rigid cystoscope and ...
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  Mentions: Technical University of Munich
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