Urology -Optical Coherence Tomography News

Articles in category: Urology

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1. Segmentation of the Urothelium in Optical Coherence Tomography Images with Dynamic Contrast
  
  Explore bioRxiv.org Feb 27 2021 Urology
  
  Significance: Speckle variations induced by intracellular motion (IM) in the urothelium was observed in optical coherence tomography (OCT) images. It is feasible to use the IM as a dynamic contrast to segment the urothelium with only two sequential OCT images. This new method opens the possibility of tracking the distribution of the urothelial cells to identify the microinvasion of bladder tumors. Approach: With fresh porcine bladder tissue, IM was analyzed by tracking speckle variations using autocorrelation function, then quantified with CONTINE algorism to identify the decorrelation time (DT) of the speckle variations. Variance analysis is conducted to show IM amplitude ...
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  Mentions: Cleveland Clinic Hui Wang
2. The role of cavitation in energy delivery and stone damage during laser lithotripsy
  
  Explore Mary Ann Liebert, Inc. Jan 31 2021 Urology
  
  Purpose: While cavitation during laser lithotripsy contributes to the Moses effect, the impact of cavitation on stone damage is less clear. Using different laser settings, we investigate the role of cavitation bubbles in energy delivery and stone damage. Materials and Methods: The role of cavitation in laser energy delivery was characterized using photodetector measurements synced with high-speed imaging for laser pulses of varying durations. BegoStone samples were treated with the laser fiber oriented perpendicularly in contact with the stone in water or in air to assess the impact of cavitation on crater formation. Crater volume and geometry were quantified using ...
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3. In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography
  
  Explore Home (World Scientific) Dec 27 2020 Urology
  
  The paper presents the results of a study of the female urethra in cases of urethral pain syndrome (UPS) and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography (CP OCT). Urethral wall structure was studied in 86 patients; 233 CP OCT images were collected. A comparative qualitative analysis of three groups of CP OCT images — “norm”, “Inflammation” and “UPS” — identified that despite the absence of a clear inflammatory factor in the patient’s examination, the urethral tissues in UPS were in an altered state. The changes in the urethral wall with UPS and in cases of ...
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  Mentions: Grigory V. Gelikonov Olga S. Streltsova Elena B. Kiseleva
4. Toward image quality assessment in optical coherence tomography (OCT) of rat kidney
  
  Explore ScienceDirect Sep 10 2020 Urology
  
  Background Optical coherence tomography (OCT) is a useful tool for the evaluation of structure and function of the kidney, but the image quality can be affected by many factors. Objective The objective of this study was to assess the image quality of different OCT systems in OCT imaging of the living kidney. Methods One swept-source OCT (SSOCT) of 1300 nm, one spectral domain OCT (SDOCT) of 1300 nm and another of 900 nm were used. A FeO phantom was used to establish the point spread function (PSF). Rat kidneys were imaged for image quality assessment. Light penetration in the kidney ...
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  Mentions: University of Colorado Fujian Normal University
5. The analysis of prostate tissue by optical coherence tomography (Thesis)
  
  Explore Research Explorer Jul 6 2020 Urology , Student Theses
  
  The prostate is the gland located around the urethra beneath the bladder that produces most of the sperm fluid (figure 1). Prostate cancer (PCa) accounted for almost 1 in 5 new cancer diagnoses in males in the USA in 2017, and 1 in 8 men will develop invasive cancer in the prostate in their lifetime [1]. Prostate cancer is the second most common cancer in men (after skin cancer) and the second most common cause of cancer-related death (after lung cancer). Advances in screening, diagnosis, and treatment have led to an overall survival increase from 69% in 1991-1995 to 89 ...
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  Mentions: Academic Medical Center at the University of Amsterdam
6. Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis
  
  Explore Karger Publishers Jun 18 2020 Oncology , Urology
  
  Objective: To systematically evaluate the diagnostic efficacy of confocal laser endomicroscopy (CLE) in detection of bladder cancer. Methods: A systematic literature search on CLE in diagnosing bladder cancer in PubMed, Embase, and the Cochrane Library databases was performed. A bivariate meta-regression model was used for meta-analysis to evaluate the pooled diagnostic value of CLE. Results: A total of 5 eligible studies involving 302 lesions were available for this meta-analysis. In a per-lesion analysis, pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver-operating curve (SROC) area under the curve (AUC) of CLE ...
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  Mentions: Fudan University
7. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons
  
  Explore Home Page May 31 2020 Cardiology , Ophthalmology , Urology
  
  Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and their associated cardiovascular disease. Homology between the eye and the kidney suggests that noninvasive imaging of the retinal vessels can detect these microvascular alterations to improve targeting of at-risk patients ...
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  Mentions: University College London Pearse A. Keane
8. En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients
  
  Explore Wiley Online Library Feb 21 2020 Urology
  
  The increase histopathological evaluation of prostatectomy specimens rises the workload on pathologists. Automated histopathology systems, preferably directly on unstained specimens, would accelerate the pathology workflow. In this study, we investigate the potential of quantitative analysis of Optical Coherence Tomography (OCT) to separate benign from malignant prostate tissue automatically. Twenty fixated prostates were cut, from which 54 slices were scanned by OCT. Quantitative OCT metrics (attenuation coefficient, residue, goodness‐of‐fit) were compared for different tissue types, annotated on the histology slides. To avoid misclassification, the poor‐quality slides, and edges of annotations were excluded. Accurate registration of OCT data with ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
9. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop
  
  Explore RSC Publishing Home Feb 6 2020 Urology
  
  Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm to the patient. Nowadays, optical modalities, such as optical coherence tomography (OCT) and Raman spectroscopy (RS), have proven to detect cancer in real time and can provide more detailed clinical ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Peter E. Andersen
10. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography
  
  Explore archivesofpathology.org Jul 30 2019 Urology
  
  Context.— The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) has had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (μOCT) that generates depth-resolved tissue images at a high frame rate with an isotropic resolution of 1 μm. Objective.— To demonstrate that optical images obtained with μOCT provide cellular-level contrast in prostate specimens ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
11. Diagnostic accuracy of optical coherence tomography for the diagnosis of bladder cancer: A systematic review and meta-analysis
  
  Explore ScienceDirect Jun 25 2019 Urology
  
  Background Bladder cancer is the fourth most common malignancy in men and a considerable disease burden globally. Multiple studies have focused on the accuracy of optical coherence tomography for bladder cancer diagnosis; however, the findings are inconsistent. Here, we assessed the accuracy of optical coherence tomography for bladder cancer diagnosis. Methods Embase, PubMed, Medline, Web of Science, and the Cochrane Library database were searched for relevant studies from the earliest date available through March 11, 2019. Studies evaluating the accuracy of optical coherence tomography bladder cancer diagnosis were included. Pooled sensitivity, specificity, and area under the curve values of weighted ...
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12. The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
  
  Explore Wiley Online Library May 23 2019 Urology
  
  Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology ...
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  Mentions: Ton G. van Leeuwen Daniël M. de Bruin Theo M. de Reijke
13. Apelin as a Potential Treatment for Chronic Kidney Disease
  
  Explore Home - ClinicalTrials.gov May 20 2019 Urology , Clinical Trials
  
  Chronic kidney disease (CKD) affects 8-16% of the world's population, and is independently associated with cardiovascular disease (CVD). As renal function declines, rates of major adverse cardiovascular events, cardiovascular and all-cause mortality increase. In addition to hypertension, increased arterial stiffness is characteristic of CKD, a marker of CVD risk, and an independent predictor of mortality in CKD patients. The endothelium is an important regulator of arterial stiffness, and endothelial dysfunction is a feature of CKD and a predictor of CVD. Current treatment of CKD is limited and aims to reduce blood pressure and proteinuria through the use of angiotensin ...
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14. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography
  
  Explore archivesofpathology.org Dec 16 2018 Urology
  
  Context.— The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) have had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (μOCT) that generates depth-resolved tissue images at a high frame rate with an isotropic resolution of 1 μm. Objective.— To demonstrate that optical images obtained with μOCT provide cellular-level contrast in prostate specimens ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
15. Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review
  
  Explore Home - Springer Nov 27 2018 Urology
  
  Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT in humans up to December 2017. Reviews were excluded. Case reports were excluded, unless they presented a landmark in the development of OCT. Results Out of 878 articles, 17 relevant ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
16. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
  
  Explore MDPI Open Access Journals Platform Nov 23 2018 Oncology , Urology
  
  We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder wall for suspicious lesions with the ability to discriminate malignant tissue from healthy urothelium. Upon identification of degenerated tissue via OCT, RS was implemented to determine the molecular characteristics via ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
17. One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen
  
  Explore Wiley Online Library Nov 22 2018 Urology
  
  Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study is to validate a registration method of quantitative OCT parameters to histological tissue outcome through one‐to‐one registration of OCT with histology. We matched OCT images of unstained fixated ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
18. Focal Prostate Imaging With CLE and OCT (FPI)
  
  Explore Home - ClinicalTrials.gov May 22 2018 Urology , Clinical Trials
  
  The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging modalities with potential for in-vivo prostate imaging. The investigators anticipate that integrating focal imaging with MRI/TRUS fusion will further improve prostate cancer detection and provides a real-time histopathological threedimensional representation of the tumor lesions. This is an investigator-initiated, prospective in-vivo safety and feasibility study with transperineal template mapping biopsies (TTMB) and two focal imaging methods, CLE and OCT, in prostate tissue.
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  Mentions: Academic Medical Center at the University of Amsterdam Jean J. M. C. H. de la Rosette
19. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
  
  Explore JRP-JMIR Research Protocols May 22 2018 Urology
  
  Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. Objective: This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
20. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound
  
  Explore SPIE Digital Library Feb 17 2018 Urology
  
  Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA®) was used for reconstruction and coregistration of CT, OCT, and ELUS. Finally, CT was used to obtain exact probe localization. Coregistered OCT and ELUS datasets were compared with histology. Coregistration with three-dimensional ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
21. Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography
  
  Explore SPIE Digital Library Feb 13 2018 Urology
  
  Prostate cancer (PCa) is a heterogeneous disease with multifocal origin. In current clinical care, the Gleason scoring system is the well-established diagnosis by microscopic evaluation of the tissue from trans-rectal ultrasound (TRUS) guided biopsies. Nevertheless, the sensitivity and specificity in detecting PCa can range from 40 to 50% for conventional TRUS B-mode imaging. Tissue elasticity is associated with the disease progression and elastography technique has recently shown promise in aiding PCa diagnosis. However, many cancer foci in the prostate gland has very small size less than 1 mm and those detected by medical elastography were larger than 2 mm. Hereby ...
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  Mentions: Chunhui Li Ghulam Nabi University of Dundee
22. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
  
  Explore SPIE Digital Library Dec 5 2017 Urology
  
  Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney microstructures in vivo without administering exogenous contrast agents. A murine model of CKD induced by intravenous Adriamycin (ADR) injection is evaluated by OCT. OCT images of the rat kidneys have ...
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  Mentions: University of Maryland Yu Chen
23. Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe
  
  Explore Urology Nov 29 2017 Urology
  
  Objective To assess the use of a handheld optical coherence tomography (OCT) probe for the evaluation of intraoperative surgical margins during partial nephrectomy (PN). Methods In an initial feasibility study, a radical nephrectomy specimen with a 9-cm tumor was cut into 19 sections, exposing 0 mm (n=8), 1 mm (n=6), and 2 mm (n=5) gross margins. OCT was used to determine the margin width in each specimen. Second, a prospective ex vivo assessment of 15 PN tumor specimens was performed with OCT to determine margin status and to measure the attenuation coefficient (AC) of tumor and renal ...
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24. Dutch Health-Care Startup Scinvivo to present at DMD 2017 Europe on "Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter"
  
  Explore Optical Coherence Tomography News Nov 17 2017 Urology
  
  Scinvivo talk, entitled ‘ Improving bladder cancer diagnostics with an Optical Coherence Tomography imaging catheter’, has been selected for a presentation at the Design of Medical Devices Europe Conference 2017 (DMD Europe 2017)! The central theme of this year’s conference is microfabrication for medical devices. More information about the conference can be found at: https://dmd2017.eu/ . Scinvivo will present on Tuesday November the 14 th , at 11:30u in The Strip Conference centre.
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  Mentions: Scinvivo
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