Urology -Optical Coherence Tomography News

Articles in category: Urology

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1. Volumetric mosaicing for optical coherence tomography for large area bladder wall visualization
  
  Explore Conference Proceedings Mar 8 2014 Urology
  
  Optical coherence tomography (OCT) has shown potential as a complementary imaging modality to white light cystoscopy (WLC) because it can visualize sub-surface details of the bladder wall, enabling it to stage early cancers and visualize tumors undetectable to WLC. However, the inherently small field of view (FOV) of OCT compared with the area of the bladder wall restricts its clinical utility. A large OCT FOV could improve surgical planning by enabling complete visualization of tumor margins or could aid in early cancer detection by tracking the appearance of the bladder wall over time. To overcome the limited FOV of OCT ...
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  Mentions: Stanford University Audrey K. Ellerbee
2. Multilayered disease-mimicking bladder phantom with realistic surface topology for optical coherence tomography
  
  Explore Conference Proceedings Mar 8 2014 Urology
  
  Optical coherence tomography (OCT) has shown potential as a complementary modality to white light cystoscopy (WLC), the gold standard for imaging bladder cancer. OCT can visualize sub-surface details of the bladder wall, which enables it to stage cancers and detect tumors that are otherwise invisible to WLC. Currently, OCT systems have too slow a speed and too small a field of view for comprehensive bladder imaging, which limits its clinical utility. Validation and feasibility testing of technological refinements aimed to provide faster imaging and wider fields of view necessitates a realistic bladder phantom. We present a novel process to fabricate ...
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  Mentions: Stanford University Audrey K. Ellerbee Joseph Liao
3. Optical coherence tomography provides images similar to histology and allows the performance of extensive measurements of drug-eluting metal stents in animal ureter
  
  Explore Home - Springer Mar 5 2014 Urology
  
  Optical coherence tomography (OCT) images and histology images of metal stents (MSs) inserted in animal ureters were compared, and the reliability of an OCT-based automated method for the performance of quantitative evaluation of ureteral MSs was evaluated. A zotarolimus-eluting metal stent (ZES) and a bare metal stent (BMS) were inserted in each ureter of ten pigs and six rabbits. OCT was performed in unobstructed stented ureters. Histopathologic examination of the stented ureters embedded in glycol-methacrylate took place. Quadrants of OCT images were compared to their respective histologic images by employing two independent observers who delineated different layers in the quadrants ...
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  Mentions: Imalux Niris Patras University
4. Using Optical Coherence Tomography (OCT) to Evaluate Human Donor Kidneys Prior to and Following Transplantation
  
  Explore OMICS Group Mar 1 2014 Urology
  
  The most common insult to donor kidneys destined for transplantation is Acute Tubular Necrosis (ATN). The extent of ATN will affect post-transplant function and is a significant risk factor for long-term graft function and survival. Optical Coherence Tomography (OCT) is a rapidly emerging imaging modality that can function as a type of “optical biopsy”, providing non-invasive images of tissue morphology in situ and in real-time. In this paper, we review studies that support the use of OCT and Doppler based OCT (i.e., DOCT) to image the renal microstructure and blood flow of human donor kidneys. We conclude that OCT ...
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  Mentions: University of Maryland Yu Chen
5. Optical coherence tomography diagnostics for onco–urology. Review of clinical perspectives
  
  Explore Termedia Mar 1 2014 Urology
  
  Introduction. Optical coherence tomography (OCT) is being investigated widely for use in urologic pathology. The current imaging of urogenital cancers cannot be perfect, thus, routine methods demands new updates or inventions of alternative radiological scope. OCT presents so–called “live” optical biopsy. The authors aim to review this modality for uro–oncological purposes. Matherial and methods. A series of 37 publications between 1989 and 2012 was selected and cited from GoogleScholar and PubMED/MEDLINE. The urogenital tract (bladder, ureter, scrotum organs and prostate) was imaged by OCT. Results. The overall OCT sensitivity, specificity, accuracy, negative and positive predictive values ranged ...
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  Mentions: Maciej Wojtkowski Nicolaus Copernicus University
6. From industrial laboratory directly to operating table: the vicissitudes of optical coherence tomography (OCT)
  
  Explore Termedia Mar 1 2014 Urology
  
  The current issue of the CEJU runs a paper presenting the prospect of an amazing, unconventional diagnostic method. Optical coherence tomography (OCT) is a relatively new interferometric technique of optical imaging [1]. Though physical foundations of OCT are difficult to grasp for a run–of–the–mill kind of CEJU reader (editor alike), Dr. S. Kharchenko and co–workers’ paper deserves our notice. This technique has been developed in the Massachusetts Institute of Technology twenty years ago and now OCT emerges as a powerful supplementary tool for uro–oncology. We can be really moved by amazing 3–D scans of ...
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  Mentions: Massachusetts Institute of Technology
7. Optical Coherence Tomography of the Living Human Kidney
  
  Explore Home (World Scientific) Jan 17 2014 Urology
  
  Acute tubular necrosis (ATN) induced by ischemia is the most common insult to donor kidneys destined for transplantation. ATN results from swelling and subsequent damage to cells lining the kidney tubules. In this study, we demonstrate the capability of optical coherence tomography (OCT) to image the renal microstructures of living human donor kidneys and potentially provide a measure to determine the extent of ATN. We also found that Doppler-based OCT (i.e., DOCT) reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal function. All OCT/DOCT observations were performed in a noninvasive, sterile ...
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  Mentions: University of Maryland Yu Chen Fujian Normal University
8. Full field optical coherence tomography of prostate biopsies: A step towards pre-histological diagnosis?
  
  Explore ScienceDirect Dec 31 2013 Oncology , Urology
  
  Objectives To evaluate the value of full field optical coherence tomography (FFOCT) for cancer detection on prostate biopsies Patients and methods Eight consecutive patients who underwent prostate biopsies for an elevated PSA or suspicious DRE findings were included in the study. For each patient, one to three biopsy cores were imaged with FFOCT immediately after sampling. Images obtained were analyzed by a pathologist blinded to the pathological results, and classified into three categories: non-cancerous tissue, suspicion of malignancy and prostate carcinoma. A pathological correlation analysis was further performed. Results Sixteen biopsy cores were analyzed. The median FFOCT procedure time was ...
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9. The impact of real-time 3d imaging by ultra-high speed optical coherence tomography in urothelial carcinoma
  
  Explore BioMed Central Dec 3 2013 Urology
  
  Optical coherence tomography (OCT) has become a promising diagnostic tool in many medical fields. In particular, noninvasive real-time optical biopsy of internal organs is one of the most attractive applications of OCT, enabling in situ diagnosis of carcinoma at an early stage. We used an ultra-high speed OCT system for real-time three-dimensional (3D) imaging of three excised specimens of advanced urothelial carcinoma (UC) and investigated the association of the images with results from histopathological examination. Case presentations: Case 1 was a 69-year-old man underwent radical cystectomy for muscle-invasive UC (pT2). Case 2 was a 53-year-old man underwent laparoscopic nephroureterectomy and ...
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  Mentions: Kohji Ohbayashi
10. Intraoperative optical imaging and tissue interrogation during urologic surgery
  
  Explore LWW Online Nov 19 2013 Urology
  
  Purpose of review: To review optical imaging technologies in urologic surgery aimed to facilitate intraoperative imaging and tissue interrogation. Recent findings: Emerging new optical imaging technologies can be integrated in the operating room environment during minimally invasive and open surgery. These technologies include macroscopic fluorescence imaging that provides contrast enhancement between normal and diseased tissue and microscopic imaging that provides tissue characterization. Summary: Optical imaging technologies that have reached the clinical arena in urologic surgery were reviewed, including photodynamic diagnosis, near infrared fluorescence imaging, optical coherence tomography, and confocal laser endomicroscopy.
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  Mentions: Johns Hopkins University Li-Ming Su
11. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
  
  Explore Optical Coherence Tomography News Nov 10 2013 Oncology , Urology
  
  Optical Coherence Tomography (OCT) has proven a powerful tool for ophthalmologists to make clinical decisions for a wide range of blinding diseases and the there are now ~20 million ophthalmic OCT patient scans per year. Significant progress is also being made in intravascular imaging where OCT is emerging as a tool for both clinical decision making and the understanding of cardiovascular disease and development of new therapeutic tools. OCT also has the potential to impact the understanding, diagnosis, and treatment of some forms of cancer. There are many leading research groups around the world that are making excellent progress in ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
12. Case Western Reserve University Receives NIH Grant for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Sep 17 2013 Urology , Funding
  
  Case Western Reserve University Receive at 2013 NIH Grant for $244,983 for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography. The principal investigator is Andrew Rollins. The program began in 2012 and ends in 2014. Below is a summary of the proposed work.
  
  Diagnosis and treatment of upper-tract urothelial carcinomas (UTUC) remain very challenging for urologists. Standard management for many years has been radical nephroureterectomy (RNU). However, RNU is a significant over-treatment for low-risk tumors, which have low rate of progression. Endoscopic management of these low-risk cases bears obvious advantages over RNU, including lower co-morbidity and lower ...
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  Mentions: Andrew M. Rollins National Institutes of Health Case Western Reserve University
13. Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over
  
  Explore rivistaurologia.it Sep 15 2013 Urology
  
  Bladder cancer is the most common tumor of the urinary tract, with a worldwide incidence of 8.6 x 100000 in men and 2.6 x 100000 in women (1). The majority of patients (75-85%) present as non-muscle invasive bladder cancer (NMIBC); within this category the most represented stage is Ta (70%), followed by T1 (20%) and, less frequently, carcinoma in situ (CIS) (10%) (2). The diagnosis of NMIBC and, more generally, of bladder cancer, depends on urine cytology and endoscopic examination with histological evaluation of the resected tissue. Clearly, an optimal cystoscopy with accurate transurethral resection (TUR) is of ...
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14. University of Maryland Receives NIH Grant for Age-Related Changes in Renal Morphology and Function in Chronic Kidney Disease
  
  Explore Optical Coherence Tomography News Sep 11 2013 Urology , Funding
  
  University of Maryland Received a 2013 NIH Grant for $219,084 for Age-Related Changes in Renal Morphology and Function in Chronic Kidney Disease. The principal investigator is Yu Chen. The program begain in 2012 and ends in 2014. Below is a summary of the proposed work. This application is in response to PA-09-166 "Renal Function and Chronic Kidney Disease (CKD) in Aging (R21)". CKD is a growing problem among the aging population. According to the United States Renal Data System, the number of older patients with end-stage renal disease (ESRD) has almost doubled over the last 25 years. Thus, CKD ...
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  Mentions: University of Maryland National Institutes of Health Yu Chen
15. Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
  
  Explore The Journal of Urology Aug 18 2013 Urology
  
  Purpose Knowledge on tumor stage and grade is paramount for treatment decision in Upper Urinary Tract Urothelial Carcinoma (UUT-UC), but cannot be accurately assessed by current techniques. Optical Coherence Tomography (OCT) is a technique, which can hypothetically provide the urologist with real-time intra-operative information on tumor grade and stage. In this pilot study the first results of OCT in grading and staging of UUT-UC are presented. Material & Methods Eight consecutive patients underwent URS for UUT-UC suspicion or follow-up. OCT datasets were intra-operatively obtained from the ureter and pyelum. All patients eventually underwent nephroureterectomy. OCT staging was performed by visual inspection ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
16. OCT assisted identification of the grade of encrustation of urologic catheters
  
  Explore Conference Proceedings Jun 30 2013 Urology
  
  Introduction: Ureteric stenting is a commonly used endourologic procedure for temporary and long-term drainage of an obstructed upper urinary tract. The indication for ureteric stenting is obstruction due to intrinsic (intraureteral stones, strictures, or tumors) or extrinsic (for example compressing pelvic or retroperitoneal mass) causes. Despite the fact that stents do certainly have proven benefits in all fields of urology, there are potential morbidities. The most common problem of indwelling ureteral stents is infection. As foreign body in the urinary system, stents act as a nidus for bacteria colonization, crystallization and encrustation. Bacteria induced biofilm formation predisposes for the crystallization ...
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  Mentions: Herbert Stepp
17. Visualization of synthetic mesh utilizing optical coherence tomography
  
  Explore Home - Springer May 4 2013 Gynecology , Urology
  
  Introduction and hypothesis Owing to the recent upsurge in adverse events reported after mesh-augmented pelvic organ prolapse (POP) repairs, our aim was to determine whether the location and depth of synthetic mesh can be measured postoperatively within the vaginal tissue microstructure using optical coherence tomography (OCT). Methods Seventeen patients with prior mesh-augmented repairs were recruited for participation. Patients were included if they had undergone an abdominal sacral colpopexy (ASC) or vaginal repair with mesh. Exclusion criteria were a postoperative period of <6 months, or the finding of mesh exposure on examination. OCT was used to image the vaginal wall at ...
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  Mentions: Imalux Dara F. Shalom
18. Nonculprit Coronary Plaque Characteristics of Chronic Kidney Disease
  
  Explore Circulation May 1 2013 Cardiology , Urology
  
  Background— Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography. Methods and Results— We identified 463 nonculprit plaques from 287 patients from the Massachusetts General Hospital (MGH) optical coherence tomography registry. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m 2 . A total of 402 plaques (250 patients) were in the non-CKD group and 61 plaques (37 patients) were in the CKD group. Compared ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
19. Telerobotic system designed to treat bladder cancer
  
  Explore News | Vanderbilt University Apr 6 2013 Oncology , Urology
  
  Although bladder cancer is the sixth most common form of cancer in the U.S. and the most expensive to treat, the basic method that doctors use to treat it hasn’t changed much in more than 70 years. An interdisciplinary collaboration of engineers and doctors at Vanderbilt and Columbia Universities intends to change that situation dramatically. Headed by Nabil Simaan , associate professor of mechanical engineering at Vanderbilt, the team has developed a prototype telerobotic platform designed to be inserted through natural orifices – in this case the urethra – that can provide surgeons with a much better view of bladder tumors ...
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  Mentions: Columbia University Vanderbilt University
20. Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers
  
  Explore Wiley Online Library Feb 20 2013 Urology
  
  The combined use of fluorescence cystoscopy and cross-polarization optical coherence tomography (CP OCT) with quantitative estimation of the OCT signal was assessed in 92 bladder zones. It demonstrated the diagnostic accuracy in detecting superficial bladder cancer of 93.6%, sensitivity 96.4%, specificity 92.1%, positive predictive value 87% and negative predictive value 97.9%. Quantitative estimation of OCT signal standard deviation in cross-polarization (CP OCT SD index) makes the visual criteria of CP OCT image assessment more objective. The level of CP OCT SD index for diagnosing superficial bladder cancer, including cancer in situ, was 4.32 dB and ...
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  Mentions: Nizhny Novgorod State Medical Academy Elena V. Zagaynova Natalia D. Gladkova
21. Feature Of The Week 2/3/13: Automated Segmentation Algorithm for Medical Image Processing using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Feb 1 2013 Gynecology , Urology
  
  Optical coherence tomography (OCT) is a noninvasive optical imaging technique for in vivo and in situ imaging of microstructure in biological tissues. Improvements in identification, imaging, and visualization of biological microstructures are necessary before OCT clinical use. Using the proposed algorithm, OCT images of the prostate and cervicovaginal epithelium were segmented to differentiate the cavernous nerves from the prostate gland and to detect minute changes in the epithelial layer, respectively. To detect these nerves and epithelial layer changes, three image features were employed: Gabor filter, Daubechies wavelet, and Laws filter. The Gabor feature was applied with different standard deviations in ...
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  Mentions: Johns Hopkins University Imalux Massoud Motamedi
22. New Study Shows Promise For Women Needing Mesh-Augmented Pelvic Organ Prolapse (POP) Repair
  
  Explore Optical Coherence Tomography News Dec 14 2012 Gynecology , Urology
  
  Imalux Press Release - Imalux® Corporation , manufacturer of the Niris ® Imaging System announces that the Niris 1300e has been successfully used to help physicians evaluate women for their suitability and response to mesh-augmented pelvic organ prolapse (POP) repair. The Imalux Niris 1300e Imaging System was used by researchers at North Shore Long Island Jewish Health System. They were able to image previously placed mesh located in the vaginal epithelium, and were able to measure the thickness of the epithelial tissue. These studies have generated valuable information relative to the success of the vaginal mesh placement procedures. Both studies were presented at ...
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  Mentions: Imalux FDA Imalux Niris
23. Case Western Reserve University Receives 2012 NIH Grant for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Sep 25 2012 Oncology , Urology , Funding
  
  Case Western Reserve University Received a 2012 NIH Grant for $304,012 for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography. The principal investigator is Andrew Rollins. The program started in 2012 and ends in 2014. Below is a summary of the work. D iagnosis and treatment of upper-tract urothelial carcinomas (UTUC) remain very challenging for urologists. Standard management for many years has been radical nephroureterectomy (RNU). However, RNU is a significant over-treatment for low-risk tumors, which have low rate of progression. Endoscopic management of these low-risk cases bears obvious advantages over RNU, including lower co-morbidity and lower ...
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  Mentions: Andrew M. Rollins National Institutes of Health Case Western Reserve University
24. University of Maryland College Park Receives NIH Grant for In Vivo Optical Imaging of Kidney Structure and Function
  
  Explore Optical Coherence Tomography News Sep 11 2012 Urology , Funding
  
  The University of Maryland College Park Received a 2012 NIH Grant for $114,187 for In Vivo Optical Imaging of Kidney Structure and Function. The program started in 2011 and ends in 2013. Yu Chen is the Principal Investigator. Below is a summary of the work. The overall goal of this proposal is to investigate the clinical feasibility of a new minimally-invasive multi-modal optical imaging technology for the diagnosis of kidney diseases in vivo and in real time. Multi-modal optical imaging combining high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence imaging enables comprehensive assessment of kidney structural and functional parameters ...
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  Mentions: University of Maryland National Institutes of Health Yu Chen
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