Popular Articles
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OCT Companies in the News
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(4 articles) SUNY at Stony Brook
(4 articles) Ludwig Maximilians Universität München
(3 articles) Russian Academy of Sciences
(2 articles) Nizhny Novgorod State Medical Academy
(2 articles) Stanford University
(2 articles) Medical University of Vienna
(2 articles) Baylor College of Medicine
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Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia
Explore Article SPIE Digital Library (Mar 2 2010) Oncology , Urology
We consider the cross-polarization OCT (CP OCT) that is focused on comparison of images resulting from cross-polarization and co-polarization scattering simultaneously. This technique provides information about microstructural and biochemical alterations in depolarizing tissue components (collagen). We found that mature type I collagen gives a strong signal in orthogonal polarization. CP OCT images of benign inflammatory processes always feature signal in orthogonal polarization, with layers and borders persisting to be well defined. In the presence of precancerous alterations, signal in orthogonal polarization is available in the image but it is irregular, disappearing in some areas. A CP OCT image of bladder ...
Comment on Article Mentions: Nizhny Novgorod State Medical Academy Valentin M. Gelikonov Elena V. Zagaynova
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Near-IR optical properties of canine prostate tissue using oblique-incidence reflectometry
Explore Article SPIE Digital Library (Mar 2 2010) Urology
Optical imaging systems utilizing near-infrared light sources such as optical coherence tomography (OCT) have recently been used for imaging the prostate gland. However, the optimal wavelength for deep imaging of the prostate has yet to be determined. The objective of this study is to determine the optimal near-infrared wavelength for OCT imaging of the prostate using a system that has the potential to be used in an in vivo model. An obliqueincidence single point measurement technique using a normal-detector scanning system was implemented to determine the absorption (µa) and reduced scattering coefficients (µ's) of fresh canine prostate tissue, ex vivo, ...
Comment on Article Mentions: Nathaniel M. Fried
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Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
Explore Article SPIE Digital Library (Feb 16 2010) Oncology , Urology
The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min. The therapeutical ...
Comment on Article Mentions: Nizhny Novgorod State Medical Academy Vladislav A. Kamensky Russian Academy of Sciences
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Optical coherence tomography of the upper urinary tract: Review of initial experience ex vivo and in vivo
Explore Article ScienceDirect (Feb 3 2010) Urology
Diagnostic imaging of the upper urinary tract is a cumbersome process that involves a multitude of different imaging modalities, including ultrasonography, conventional radiography, X-ray fluoroscopy (retrograde and antegrade ureteropyelography), endoscopy (cystoscopy and ureterorenoscopy) without or with biopsy, multi-detector-row computed tomography (MDCT), and magnetic resonance imaging (MRI). However, these modalities leave a diagnostic gap because they cannot demonstrate different layers of the wall of the upper urinary tract. Recent research shows that catheter-based, intraluminal probes for optical coherence tomography (OCT) with near-infrared light provide cross-sectional images from within the lumen of the upper urinary tract that distinguish between the urothelium, lamina ...
Comment on Article Mentions: Siemens Ludwig Maximilians Universität München
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Bladder cancer: Optical coherence tomography improves UCC detection
Explore Article Nature Publishing Group (Jan 13 2010) Oncology , Urology
Targeted optical coherence tomography (OCT) in combination with hexaminolevulinate (HAL) fluorescence cystoscopy improves diagnostic accuracy in detecting urothelial cell carcinoma (UCC) of the bladder, report Schmidbauer and colleagues from the Medical University of Vienna.Fluorescence cystoscopy has been shown to significantly improve detection of UCC when used as an adjunct to white-light cystoscopy. -
UroToday Seminar on Optical coherence tomography
Explore Article UroToday (Dec 3 2009) Oncology , Urology
BETHESDA, MD, USA (UroToday.com) - In his presentation, Dr. Seth Lerner discussed optical coherence tomography (OCT), a high-resolution technology using near infrared light with a unique backscatter pattern of different tissue characteristics.
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On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading
Explore Article Scitation (Sep 16 2009) Oncology , Urology
has been recently demonstrated that the cellular details of bladder epithelium embedded in speckle noise can be uncovered with time-lapse ultrahigh-resolution optical coherence tomography (TL-uOCT) by proper time-lapse frame averaging that takes advantage of cellular micromotion in fresh biological tissue ex vivo. Here, spectral-domain 3-D TL-uOCT is reported to further improve the image fidelity, and new experimental evidence is presented to differentiate normal and cancerous nuclei of rodent bladder epithelia. Results of animal cancer study reveal that despite a slight overestimation (e.g., <10%) of nuclear size (DN) to histological evaluation, TL-uOCT is capable of distinguishing normal (DN7 µm) and cancerous ...Comment on Article Mentions: Yingtian Pan SUNY at Stony Brook
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Segmentation of optical coherence tomography images for differentiation of the cavernous nerves from the prostate gland
Explore Article SPIE Digital Library (Aug 25 2009) Oncology , Urology
The cavernous nerves course along the surface of the prostate and are responsible for erectile function. Improvements in identification, imaging, and visualization of the cavernous nerves during prostate cancer surgery may improve nerve preservation and postoperative sexual potency. Two-dimensional (2-D) optical coherence tomography (OCT) images of the rat prostate were segmented to differentiate the cavernous nerves from the prostate gland. To detect these nerves, three image features were employed: Gabor filter, Daubechies wavelet, and Laws filter. The Gabor feature was applied with different standard deviations in the x and y directions. In the Daubechies wavelet feature, an 8-tap Daubechies orthonormal ...Comment on Article Mentions: Nathaniel M. Fried
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Impact of renal function on coronary plaque composition
Explore Article Oxford Journals (Aug 24 2009) Cardiology , Urology
Background. Recent studies have demonstrated that patients with chronic kidney disease are at high risk of atherosclerosis. Recently it has been found that coronary plaque components can be evaluated by integrated backscatter intravascular ultrasound (IB-IVUS), and lipid-rich plaque is associated with vulnerable plaque. The aim of the study was to investigate the relationship between renal function and tissue characterization of coronary plaque composition at the target stenotic site for percutaneous coronary intervention (PCI). Methods. We prospectively performed IB-IVUS before elective PCI in 89 consecutive patients with stable angina. According to estimated glomerular filtration rate (eGFR), they were divided into two ... -
Optical coherence tomography: a novel modality for scrotal imaging
Explore Article cuaj.ca (Aug 14 2009) Urology
Background: For patients with nonobstructive azoospermia, sperm retrieval rates remain modest. We describe the use of optical coherence tomography to improve retrieval rates and to decrease tissue destruction. Methods: Four patients underwent diagnostic testicular biopsy and imaging with the Niris optical coherence tomography de - vice. We performed a descriptive comparison between optic al coherence tomographic images and conventional histology. Results: The measured seminiferous tubule diameter differed by 16 μm between comparative imaging from optical coherence tomography and conventional histology using hematoxylin and eosin staining. Conclusion: We illustrate the usefulness of optical coherence tomography in the setting of testicular biopsy ...
Comment on Article Mentions: Imalux Imalux Niris UCSF
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Fluorescence Cystoscopy with High-Resolution Optical Coherence Tomography Imaging as an Adjunct Reduces False-Positive Findings in the Diagnosis of Urothelial Carcinoma of the Bladder
Explore Article ScienceDirect (Aug 14 2009) Oncology , Urology
Background The advantage of photodynamic diagnosis in detecting urothelial cell carcinoma (UCC) of the bladder has been demonstrated clearly, but it comes at the price of a higher false-positive rate. Optical coherence tomography (OCT) is a noninvasive, real-time, microstructural imaging modality that uses near-infrared light for a point analysis of the bladder-wall microstructure. Objective To evaluate whether adding targeted OCT analysis of lesions that are suspicious at white-light (WL) and hexaminolevulinate (HAL) fluorescence cystoscopy improves diagnostic accuracy in the detection of UCC. Design, setting, and participants In this prospective single-center study with same-patient comparison, patients with suspected UCC first received ...
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Diagnosis of Bladder Cancer With Microelectromechanical Systems-based Cystoscopic Optical Coherence Tomography
Explore Article ScienceDirect (Aug 8 2009) Urology
Objectives To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. Methods An optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and 10-μm resolution. Intraoperative COCT diagnosis was performed in 56 patients, with a total of 110 lesions examined and compared with biopsied histology. Results The overall sensitivity of COCT (94%) was significantly higher than ...Comment on Article Mentions: Yingtian Pan SUNY at Stony Brook
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Sexual dysfunction in men after surgery of colorectal carcinoma. New developments in prevention and therapy
Explore Article NCBI HomePage (Aug 1 2009) Oncology , Urology
(Article in Czech) Current procedures in the treatment of rectal carcinoma respect preservation quality of life. Development of sexual dysfunction (SD) in men after iatrogenic damage to neurovascular structures has been reported in 21-38% and significantly decreases quality of life. The author summarizes new developments in the area of surgical anatomy of Denonvilliers' fascia, occurrence of accessory pudendal arteries (APA), and neural anatomy. Introduction of robotic nerve-sparing surgery along with application of new diagnostic perioperative methods such as Doppler diagnostics and Optical Coherence Tomography will allow precise perioperative identification of neurovascular structures. New approaches in the treatment of erectile dysfunction ... -
How to improve the effectiveness of transurethral resection in nonmuscle invasive bladder cancer?
Explore Article LWW Online (Jul 4 2009) Oncology , Urology
Purpose of review: The high rate of early recurrences in nonmuscle invasive bladder cancer is considered to be strongly related to the effectiveness of transurethral resection (TUR). The aim of this article is to review methods, currently available or in development, that aim at improving TUR, with an emphasis on studies over the past year. Recent findings: It has been shown that re-TUR diminishes staging error and improves local tumour control. However, instead of simply repeating the standard procedure, it makes more sense to improve the technique itself. Modifications in TUR equipment, such as bipolar resection and laser treatment, mainly ... -
OCT-assisted control of catheter positioning in the urethra of the rabbit — A feasibility study
Explore Article ScienceDirect (Jul 1 2009) Urology
Background A fundamental precondition of local radiotherapy by means of 32P-loaded urethral catheters is a precise position with respect to the target tissue. This feasibility study investigates optical coherence tomography (OCT)-assisted examination of the catheter position and its adherence to the tissue surface. Materials and methods OCT investigations were performed using an animal model (rabbit urethra, n=4). A radial scanning OCT probe located in the lumen of the catheter provided OCT images of the catheter structure as well as of the surrounding tissue. Descriptive evaluation of the OCT images gives information about the fitting, the structure of the catheter, as ...
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Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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