Urology -Optical Coherence Tomography News

Articles in category: Urology

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1. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times
  
  Explore Home - Springer Aug 16 2016 Developmental Biology , Urology
  
  We observed in vivo kidney dysfunction with various ischemia times at 30, 75, 90, and 120 min using multi-modality optical imaging: optical coherence tomography (OCT), Doppler OCT (DOCT), and two-photon microscopy (TPM). We imaged the renal tubule lumens and glomerulus at several areas of each kidney before, during, and after ischemia of 5-month-old female Munich-Wistar rats. For animals with 30 and 75 min ischemia times, we observed that all areas were recovered after ischemia, that tubule lumens were re-opened and the blood flow of the glomerulus was re-established. For animals with 90 and 120 min ischemia times, we observed unrecovered ...
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  Mentions: University of Maryland Yu Chen Tianjin University
2. Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy
  
  Explore Elsevier Health Jul 29 2016 Urology
  
  Purposes Biopsies and cytology are cornerstones in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). However, a high rate of non-diagnostic biopsies, tumor upgrading and -staging after nephroureterectomy is observed. In this prospective in vivo study we aimed to evaluate the diagnostic accuracy of OCT for grading and staging of UTUC Material & Methods Twenty-six patients underwent diagnostic URS including biopsies and OCT imaging, followed by nephroureterectomy or segmental ureter resection. Sensitivity, specificity, negative predictive value and positive predictive value of UTUC grading and staging by OCT were evaluated according to the STARD initiative and second stage (2a and 2b ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
3. Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease
  
  Explore Home - Springer Jun 25 2016 Cardiology , Urology
  
  The progression of coronary atherosclerosis has been influenced by the presence of chronic kidney disease (CKD). This study investigated the impact of CKD stages on coronary plaque components observed on optical coherence tomography (OCT). We investigated 296 native coronary lesions with stable angina pectoris treated with stent implantation. All lesions were divided into the three groups according to the values of estimated glomerular filtration rate (eGFR, mL min −1 1.73 m −2 ): the non-CKD group (eGFR ≥60, n = 142), CKD group (15 ≤ eGFR < 60, n = 126), and end-stage kidney disease (ESKD) group (eGFR <15 and/or hemodialysis, n = 28 ...
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  Mentions: Tokyo Medical & Dental University Keiichi Hishikari
4. High efficiency for prostate biopsy qualification with full-field OCT after training
  
  Explore Conference Proceedings Jun 13 2016 Oncology , Urology
  
  Full-field optical coherence tomography (FFOCT) offers a fast and non-destructive method of obtaining images of biological tissues at ultrahigh resolution, approaching traditional histological sections. In the context of prostate cancer diagnosis involving multiple biopsies, FFOCT could be used to validate the cores just after they are obtained in order to guide the number of biopsies to be performed. The aim of the study was to define and test a training protocol for efficient FFOCT prostate biopsy assessment. Three readers (a pathologist with previous experience with FFOCT, a pathologist new to FFOCT, and a urologist new to FFOCT) were trained to ...
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  Mentions: UCLA LLTech Eugénie Dalimier
5. Optical Coherence Tomography of the Aging Kidney
  
  Explore ectrx.org May 5 2016 Urology
  
  Objectives: The aging kidney exhibits a progressive decline in renal function with characteristic histopathologic changes and is a risk factor for renal transplant. However, the degree to which the kidney exhibits this decline depends on several factors that vary from one individual to the next. Optical coherence tomography is an evolving noninvasive imaging technology that has recently been used to evaluate acute tubular necrosis of living-human donor kidneys before their transplant. With the increasing use of kidneys from older individuals, it is important to determine whether optical coherence tomography also can distinguish the histopathology associated with aging. Materials and Methods ...
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  Mentions: University of Maryland Yu Chen
6. Combined optical coherence tomography and optical coherence elastography for glomerulonephritis classification
  
  Explore Conference Proceedings Mar 13 2016 Urology
  
  Acute Glomerulonephritis caused by anti-glomerular basement membrane disease has a high mortality due to delayed diagnosis. Thus, an accurate and early diagnosis is critical for preserving renal function. Currently, blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution. Optical coherence tomography (OCT) is a noninvasive imaging technique that provides superior spatial resolution (micron scale) as compared to ultrasound and CT. Pathological changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signal, such as optical attenuation and speckle variance. Moreover, OCT does not rely ...
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  Mentions: University of Chicago Kirill V. Larin University of Houston
7. Catheter-based intraluminal optical coherence tomography of the normal human upper urinary tract in vivo: proof of concept and comparison with an ex-vivo porcine model
  
  Explore Home - Bladder Journal Feb 24 2016 Urology
  
  Objective : Single-slice, cross-sectional, intraluminal optical-coherence-tomography (OCT) is a new destruction-free optical imaging method that could be applied clinically to examine the upper urinary tract from within. In-vivo access to the human upper urinary tract (UUT) was attempted. Similar performance statistics as in ex-vivo porcine UUT were expected for delineation of different wall layers by in-vivo OCT of human UUTs. MATERIALS AND METHODS : Institutional ethics committee approved OCT in a volunteer sample of 15 patients suspected of having UUT pathology (urolithiasis, strictures, urothelial carcinoma (UC)). Commercially available, catheter-mounted 400-μm-OCT-probes (lateral resolution, < 20 µm) were introduced through a rigid cystoscope and ...
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  Mentions: Technical University of Munich
8. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling
  
  Explore Wiley Online Library Feb 9 2016 Oncology , Urology
  
  The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber VU University Amsterdam
9. Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer
  
  Explore tct.sagepub.com Jan 28 2016 Urology
  
  Objective: To design and demonstrate a customized tool to generate histologic sections of the prostate that directly correlate with needle-based optical coherence tomography pullback measurements. Materials and Methods: A customized tool was created to hold the prostatectomy specimens during optical coherence tomography measurements and formalin fixation. Using the tool, the prostate could be sliced into slices of 4 mm thickness through the optical coherence tomography measurement trajectory. In this way, whole-mount pathology slides were produced in exactly the same location as the optical coherence tomography measurements were performed. Full 3-dimensional optical coherence tomography pullbacks were fused with the histopathology slides ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber VU University Amsterdam
10. Percutaneous Needle Based Optical Coherence Tomography for the Differentiation of Renal Masses: a Pilot Cohort
  
  Explore The Journal of Urology Dec 22 2015 Urology
  
  To view the full text, please login as a subscribed user or purchase a subscription . Click here to view the full text on ScienceDirect. The aim of this study is to determine the ability of percutaneous needle based Optical Coherence Tomography (OCT) to differentiate renal masses, by using the attenuation coefficient (μOCT, mm-1) as a quantitative measure. Percutaneous needle based OCT of the kidney was performed in patients presenting with a solid renal mass.
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
11. Optical coherence tomography-guided percutaneous coronary intervention in pre-terminal chronic kidney disease with no radio-contrast administration
  
  Explore Oxford Journals Dec 21 2015 Cardiology , Urology
  
  A 67-year-old man with advanced chronic kidney disease (CKD) (creatinine = 4.5 mg/dL, eGFR = 13 mL/min/1.73 m 2 ) not requiring haemodialysis presented with progressive angina. Diagnostic angiography with ultra-low radio-contrast volume (12 mL, contrast volume/eGFR ratio <1) revealed significant stenosis in the left anterior descending (LAD) artery ( Panel A ). The lesion was haemodynamically significant (fractional flow reserve: 0.77). Post-angiography, the …
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  Mentions: Cardiovascular Research Foundation University of Sydney Martin B. Leon
12. Diagnostics techniques in nonmuscle invasive bladder cancer
  
  Explore Indian Journal of Urology (IJU) Nov 29 2015 Urology
  
  Introduction: Nonmuscle invasive bladder cancer (NMIBC) is the most common presentation of bladder cancer and is often treatable with endoscopic resection and intravesical therapies. Cystoscopy and urine cytology are the gold standard in diagnosis and surveillance but are limited by their sensitivity in some situations. We seek to provide an overview of recent additions to the diagnostic armamentarium for urologists treating this disease. Methods: Articles were identified through a literature review of articles obtained through PubMed searches including the terms “bladder cancer”and various diagnostic techniques described in the article. Results: A variety of urinary biomarkers are available to assist ...
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  Mentions: University of Minnesota
13. A Pilot Study of In Vivo Confocal Laser Endomicroscopy of Upper Tract Urothelial Carcinoma
  
  Explore Mary Ann Liebert, Inc. publishers Oct 3 2015 Urology
  
  Purpose: Tissue diagnosis of upper tract urothelial carcinoma (UTUC) is limited by variance in tumor sampling by standard ureteroscopic biopsy. Optical imaging technologies can potentially improve UTUC diagnosis, surveillance, and endoscopic treatment. We previously demonstrated in vivo optical biopsy of urothelial carcinoma of the bladder using confocal laser endomicroscopy (CLE). In this study, we evaluated a new 0.85-mm imaging probe in the upper urinary tract and demonstrated feasibility and compatibility with standard ureteroscopes to achieve in vivo optical biopsy of UTUC. Patients, Materials and Methods: Fourteen patients scheduled for ureteroscopy of suspected upper tract lesions or surveillance of UTUC ...
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  Mentions: Stanford University
14. Apparatus And Methods For NON-INVASIVE Assessment Of Transplant Kidney Viability
  
  Explore patentscope.wipo.int Jul 24 2015 Urology , Patents
  
  A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire ...
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  Mentions: University of Maryland Yu Chen Jeremiah Wierwille
15. Prostate cancer diagnosis: the feasibility of needle-based optical coherence tomography
  
  Explore SPIE | Journal Jul 14 2015 Urology
  
  The objective of this study is to demonstrate the feasibility of needle-based optical coherence tomography (OCT) and functional analysis of OCT data along the full pullback trajectory of the OCT measurement in the prostate, correlated with pathology. OCT images were recorded using a commercially available C7-XR™ OCT Intravascular Imaging System interfaced to a C7 Dragonfly™ intravascular 0.9-mm-diameter imaging probe. A computer program was constructed for automated image attenuation analysis. First, calibration of the OCT system for both the point spread function and the system roll-off was achieved by measurement of the OCT signal attenuation from an extremely weakly scattering ...
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  Mentions: Dirk J. Faber Ton G. van Leeuwen Lightlab C7 XR OCT Imaging System
16. Catheter-based intraluminal optical coherence tomography: mcomparison with digital light microscopy of ureter wall morphometry in porcine specimens
  
  Explore Home - Bladder Journal Jul 11 2015 Urology
  
  OBJECTIVE: Reproducibility and agreement of width estimates for urothelium, lamina propria, and muscle layer of normal porcine ureter wall ex vivo were compared between catheter-mounted, intraluminal cross-sectional optical coherence tomography (OCT), as a new destruction-free optical imaging method that could be applied clinically to examine the upper urinary tract from within if found to reliably delineate its different anatomical layers, and whole-mount low-power digital light microscopy (DLM). MATERIALS AND METHODS: Eleven ex-vivo-specimens of porcine ureter were flushed with normal saline solution prior to OCT (catheter diameter, 0.014 inch, wavelength, 1300 ± 20 nm, LightLab Imaging, Inc., Westford, MA, USA) at ...
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  Mentions: St. Jude Medical
17. Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores
  
  Explore Home - Springer Jun 24 2015 Oncology , Urology
  
  Objectives To evaluate the diagnostic accuracy (Acc) of full-field optical coherence tomography (FFOCT) for cancer detection on prostate biopsy. Materials and methods Thirty-eight consecutive patients with elevated PSA and/or suspicious digital rectal examination were prospectively included. For each patient, 1–10 cores were randomly selected and imaged with FFOCT immediately after sampling. The images obtained were de-identified and analyzed by three pathologists blinded to the results of pathological evaluation. The overall average Acc was measured, as well as sensitivity (Se), specificity (Sp), positive and negative predictive values (PPV and NPV). The Acc learning curve was assessed by multivariate logistic ...
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  Mentions: Eugénie Dalimier
18. Collateral damage to the ureter and Nitinol stone baskets during thulium fiber laser lithotripsy
  
  Explore Wiley Online Library Apr 16 2015 Urology
  
  Background The experimental Thulium fiber laser (TFL) is currently being studied as a potential alternative lithotripter to the clinical gold standard Holmium:YAG laser. Safety studies characterizing undesirable Holmium:YAG laser-induced damage to ureter tissue and stone baskets have been previously reported. Similarly, this study characterizes TFL induced ureter and stone basket damage. Methods A TFL beam with energy of 35 mJ per pulse, pulse duration of 500 µs, and variable pulse rates of 50–500 Hz, was delivered through 100-µm-core optical fibers, to either porcine ureter wall, in vitro , or a standard 1.9-Fr Nitinol stone basket wire ...
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  Mentions: Johns Hopkins University University of North Carolina Nathaniel M. Fried
19. Georgetown University Receives NIH Grant for Non-Invasive Evaluation of Transplant Kidney using OCT
  
  Explore Optical Coherence Tomography News Apr 14 2015 Urology , Funding
  
  Georgetown University Receives a 2015 NIH Grant for $388,865 for Non-Invasive Evaluation of Transplant Kidney using OCT. The principal investigator is Peter Andrews. The program began in 2014 and ends in 2016. Below is a summary of the proposed work. There is currently a worldwide shortage of kidneys for transplantation due mainly to the fact that there is no reliable means to determine their viability (i.e., kidneys stored for long periods of time, etc.). Also, following transplantation, kidneys oftn do not function immediately and their status is unclear. Previously, we have shown that the histopathology of living, superficial ...
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  Mentions: National Institutes of Health Georgetown University
20. Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts
  
  Explore patentscope.wipo.int Apr 1 2015 Gastroenterology , Gynecology , Oncology , Pulmonology , Urology , Patents
  
  A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...
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  Mentions: Zhongping Chen UC Irvine Qifa Zhou
21. Optical coherence tomography (OCT) of a murine model of chronic kidney disease
  
  Explore Conference Proceedings Mar 28 2015 Urology
  
  Chronic Kidney Disease (CKD) is characterized by a progressive loss in renal function over time. Pathology can provide valuable insights into the progression of CKD by analyzing the status of glomeruli and the uriniferous tubules over time. Optical coherence tomography (OCT) is a new procedure that can analyze the microscopic structure of the kidney in a non-invasive manner. This is especially important because there are significant artifacts associated with excision biopsies and immersion fixation procedures. Recently, we have shown that OCT can provide real time images of kidney microstructure and Doppler OCT (DOCT) can image glomerular renal blood flow in ...
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  Mentions: University of Maryland Yu Chen Georgetown University
22. Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography
  
  Explore opticsinfobase.org Mar 24 2015 Urology
  
  Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is ...
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  Mentions: Ontario Cancer Institute University of Toronto I. Alex Vitkin
23. Current and evolving uses of optical coherence tomography in the genitourinary tract
  
  Explore Home - Springer Feb 15 2015 Urology
  
  Optical coherence tomography is an emerging imaging modality that provides high-resolution, real-time, cross-sectional visualization of urologic tissue with promising results. Early studies have demonstrated detailed, accurate histologic information of tissues sampled. Optical coherence tomography (OCT) has also been applied in evaluating malignancy of the bladder, prostate, and kidney. In the bladder, it can assist in the identification, biopsy, and intraoperative resection of lesions suspicious for bladder cancer. Intraoperative use of OCT during radical prostatectomy can improve visualization of the neurovascular bundle and surgical margins. Several small, ex vivo studies have also shown promising results in the ability of OCT to ...
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  Mentions: University of Florida Li-Ming Su Imalux Niris
24. Feature Of The Week 01/25/15: Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer.
  
  Explore Optical Coherence Tomography News Jan 25 2015 Oncology , Urology
  
  Prostate cancer (PCa) is the most common non-cutaneous malignancy in men. Men suspected with PCa are then offered transrectal ultrasound (TRUS) guided prostate biopsies to confirm the diagnosis, which falls short of making a reliable differentiation between cancer and benign hyperplasia of the gland. Suspected cancerous lesions tend to be stiffer (or harder to feel) than benign tissue. Various elastography modalities such as Ultrasound elastography and MRI elastography are known to have poor spatial resolution, which limits their ability to differentiate small lesions and in identifying early and subtle changes. OCT is an optical imaging technique that enables high-resolution, cross-sectional ...
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  Mentions: University of Washington Ruikang K. Wang Chunhui Li
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