Urology -Optical Coherence Tomography News

Articles in category: Urology

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1. The impact of real-time 3d imaging by ultra-high speed optical coherence tomography in urothelial carcinoma
  
  Explore BioMed Central Dec 3 2013 Urology
  
  Optical coherence tomography (OCT) has become a promising diagnostic tool in many medical fields. In particular, noninvasive real-time optical biopsy of internal organs is one of the most attractive applications of OCT, enabling in situ diagnosis of carcinoma at an early stage. We used an ultra-high speed OCT system for real-time three-dimensional (3D) imaging of three excised specimens of advanced urothelial carcinoma (UC) and investigated the association of the images with results from histopathological examination. Case presentations: Case 1 was a 69-year-old man underwent radical cystectomy for muscle-invasive UC (pT2). Case 2 was a 53-year-old man underwent laparoscopic nephroureterectomy and ...
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  Mentions: Kohji Ohbayashi
2. Intraoperative optical imaging and tissue interrogation during urologic surgery
  
  Explore LWW Online Nov 19 2013 Urology
  
  Purpose of review: To review optical imaging technologies in urologic surgery aimed to facilitate intraoperative imaging and tissue interrogation. Recent findings: Emerging new optical imaging technologies can be integrated in the operating room environment during minimally invasive and open surgery. These technologies include macroscopic fluorescence imaging that provides contrast enhancement between normal and diseased tissue and microscopic imaging that provides tissue characterization. Summary: Optical imaging technologies that have reached the clinical arena in urologic surgery were reviewed, including photodynamic diagnosis, near infrared fluorescence imaging, optical coherence tomography, and confocal laser endomicroscopy.
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  Mentions: Johns Hopkins University Li-Ming Su
3. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
  
  Explore Optical Coherence Tomography News Nov 10 2013 Oncology , Urology
  
  Optical Coherence Tomography (OCT) has proven a powerful tool for ophthalmologists to make clinical decisions for a wide range of blinding diseases and the there are now ~20 million ophthalmic OCT patient scans per year. Significant progress is also being made in intravascular imaging where OCT is emerging as a tool for both clinical decision making and the understanding of cardiovascular disease and development of new therapeutic tools. OCT also has the potential to impact the understanding, diagnosis, and treatment of some forms of cancer. There are many leading research groups around the world that are making excellent progress in ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
4. Case Western Reserve University Receives NIH Grant for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Sep 17 2013 Urology , Funding
  
  Case Western Reserve University Receive at 2013 NIH Grant for $244,983 for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography. The principal investigator is Andrew Rollins. The program began in 2012 and ends in 2014. Below is a summary of the proposed work.
  
  Diagnosis and treatment of upper-tract urothelial carcinomas (UTUC) remain very challenging for urologists. Standard management for many years has been radical nephroureterectomy (RNU). However, RNU is a significant over-treatment for low-risk tumors, which have low rate of progression. Endoscopic management of these low-risk cases bears obvious advantages over RNU, including lower co-morbidity and lower ...
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  Mentions: Andrew M. Rollins National Institutes of Health Case Western Reserve University
5. Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over
  
  Explore rivistaurologia.it Sep 15 2013 Urology
  
  Bladder cancer is the most common tumor of the urinary tract, with a worldwide incidence of 8.6 x 100000 in men and 2.6 x 100000 in women (1). The majority of patients (75-85%) present as non-muscle invasive bladder cancer (NMIBC); within this category the most represented stage is Ta (70%), followed by T1 (20%) and, less frequently, carcinoma in situ (CIS) (10%) (2). The diagnosis of NMIBC and, more generally, of bladder cancer, depends on urine cytology and endoscopic examination with histological evaluation of the resected tissue. Clearly, an optimal cystoscopy with accurate transurethral resection (TUR) is of ...
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6. University of Maryland Receives NIH Grant for Age-Related Changes in Renal Morphology and Function in Chronic Kidney Disease
  
  Explore Optical Coherence Tomography News Sep 11 2013 Urology , Funding
  
  University of Maryland Received a 2013 NIH Grant for $219,084 for Age-Related Changes in Renal Morphology and Function in Chronic Kidney Disease. The principal investigator is Yu Chen. The program begain in 2012 and ends in 2014. Below is a summary of the proposed work. This application is in response to PA-09-166 "Renal Function and Chronic Kidney Disease (CKD) in Aging (R21)". CKD is a growing problem among the aging population. According to the United States Renal Data System, the number of older patients with end-stage renal disease (ESRD) has almost doubled over the last 25 years. Thus, CKD ...
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  Mentions: University of Maryland National Institutes of Health Yu Chen
7. Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
  
  Explore The Journal of Urology Aug 18 2013 Urology
  
  Purpose Knowledge on tumor stage and grade is paramount for treatment decision in Upper Urinary Tract Urothelial Carcinoma (UUT-UC), but cannot be accurately assessed by current techniques. Optical Coherence Tomography (OCT) is a technique, which can hypothetically provide the urologist with real-time intra-operative information on tumor grade and stage. In this pilot study the first results of OCT in grading and staging of UUT-UC are presented. Material & Methods Eight consecutive patients underwent URS for UUT-UC suspicion or follow-up. OCT datasets were intra-operatively obtained from the ureter and pyelum. All patients eventually underwent nephroureterectomy. OCT staging was performed by visual inspection ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
8. OCT assisted identification of the grade of encrustation of urologic catheters
  
  Explore Conference Proceedings Jun 30 2013 Urology
  
  Introduction: Ureteric stenting is a commonly used endourologic procedure for temporary and long-term drainage of an obstructed upper urinary tract. The indication for ureteric stenting is obstruction due to intrinsic (intraureteral stones, strictures, or tumors) or extrinsic (for example compressing pelvic or retroperitoneal mass) causes. Despite the fact that stents do certainly have proven benefits in all fields of urology, there are potential morbidities. The most common problem of indwelling ureteral stents is infection. As foreign body in the urinary system, stents act as a nidus for bacteria colonization, crystallization and encrustation. Bacteria induced biofilm formation predisposes for the crystallization ...
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  Mentions: Herbert Stepp
9. Visualization of synthetic mesh utilizing optical coherence tomography
  
  Explore Home - Springer May 4 2013 Gynecology , Urology
  
  Introduction and hypothesis Owing to the recent upsurge in adverse events reported after mesh-augmented pelvic organ prolapse (POP) repairs, our aim was to determine whether the location and depth of synthetic mesh can be measured postoperatively within the vaginal tissue microstructure using optical coherence tomography (OCT). Methods Seventeen patients with prior mesh-augmented repairs were recruited for participation. Patients were included if they had undergone an abdominal sacral colpopexy (ASC) or vaginal repair with mesh. Exclusion criteria were a postoperative period of <6 months, or the finding of mesh exposure on examination. OCT was used to image the vaginal wall at ...
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  Mentions: Imalux Dara F. Shalom
10. Nonculprit Coronary Plaque Characteristics of Chronic Kidney Disease
  
  Explore Circulation May 1 2013 Cardiology , Urology
  
  Background— Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography. Methods and Results— We identified 463 nonculprit plaques from 287 patients from the Massachusetts General Hospital (MGH) optical coherence tomography registry. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m 2 . A total of 402 plaques (250 patients) were in the non-CKD group and 61 plaques (37 patients) were in the CKD group. Compared ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
11. Telerobotic system designed to treat bladder cancer
  
  Explore News | Vanderbilt University Apr 6 2013 Oncology , Urology
  
  Although bladder cancer is the sixth most common form of cancer in the U.S. and the most expensive to treat, the basic method that doctors use to treat it hasn’t changed much in more than 70 years. An interdisciplinary collaboration of engineers and doctors at Vanderbilt and Columbia Universities intends to change that situation dramatically. Headed by Nabil Simaan , associate professor of mechanical engineering at Vanderbilt, the team has developed a prototype telerobotic platform designed to be inserted through natural orifices – in this case the urethra – that can provide surgeons with a much better view of bladder tumors ...
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  Mentions: Columbia University Vanderbilt University
12. Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers
  
  Explore Wiley Online Library Feb 20 2013 Urology
  
  The combined use of fluorescence cystoscopy and cross-polarization optical coherence tomography (CP OCT) with quantitative estimation of the OCT signal was assessed in 92 bladder zones. It demonstrated the diagnostic accuracy in detecting superficial bladder cancer of 93.6%, sensitivity 96.4%, specificity 92.1%, positive predictive value 87% and negative predictive value 97.9%. Quantitative estimation of OCT signal standard deviation in cross-polarization (CP OCT SD index) makes the visual criteria of CP OCT image assessment more objective. The level of CP OCT SD index for diagnosing superficial bladder cancer, including cancer in situ, was 4.32 dB and ...
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  Mentions: Nizhny Novgorod State Medical Academy Elena V. Zagaynova Natalia D. Gladkova
13. Feature Of The Week 2/3/13: Automated Segmentation Algorithm for Medical Image Processing using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Feb 1 2013 Gynecology , Urology
  
  Optical coherence tomography (OCT) is a noninvasive optical imaging technique for in vivo and in situ imaging of microstructure in biological tissues. Improvements in identification, imaging, and visualization of biological microstructures are necessary before OCT clinical use. Using the proposed algorithm, OCT images of the prostate and cervicovaginal epithelium were segmented to differentiate the cavernous nerves from the prostate gland and to detect minute changes in the epithelial layer, respectively. To detect these nerves and epithelial layer changes, three image features were employed: Gabor filter, Daubechies wavelet, and Laws filter. The Gabor feature was applied with different standard deviations in ...
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  Mentions: Johns Hopkins University Imalux Massoud Motamedi
14. New Study Shows Promise For Women Needing Mesh-Augmented Pelvic Organ Prolapse (POP) Repair
  
  Explore Optical Coherence Tomography News Dec 14 2012 Gynecology , Urology
  
  Imalux Press Release - Imalux® Corporation , manufacturer of the Niris ® Imaging System announces that the Niris 1300e has been successfully used to help physicians evaluate women for their suitability and response to mesh-augmented pelvic organ prolapse (POP) repair. The Imalux Niris 1300e Imaging System was used by researchers at North Shore Long Island Jewish Health System. They were able to image previously placed mesh located in the vaginal epithelium, and were able to measure the thickness of the epithelial tissue. These studies have generated valuable information relative to the success of the vaginal mesh placement procedures. Both studies were presented at ...
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  Mentions: Imalux FDA Imalux Niris
15. Case Western Reserve University Receives 2012 NIH Grant for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Sep 25 2012 Oncology , Urology , Funding
  
  Case Western Reserve University Received a 2012 NIH Grant for $304,012 for Staging of Upper Tract Urothelial Cancer with Optical Coherence Tomography. The principal investigator is Andrew Rollins. The program started in 2012 and ends in 2014. Below is a summary of the work. D iagnosis and treatment of upper-tract urothelial carcinomas (UTUC) remain very challenging for urologists. Standard management for many years has been radical nephroureterectomy (RNU). However, RNU is a significant over-treatment for low-risk tumors, which have low rate of progression. Endoscopic management of these low-risk cases bears obvious advantages over RNU, including lower co-morbidity and lower ...
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  Mentions: Andrew M. Rollins National Institutes of Health Case Western Reserve University
16. University of Maryland College Park Receives NIH Grant for In Vivo Optical Imaging of Kidney Structure and Function
  
  Explore Optical Coherence Tomography News Sep 11 2012 Urology , Funding
  
  The University of Maryland College Park Received a 2012 NIH Grant for $114,187 for In Vivo Optical Imaging of Kidney Structure and Function. The program started in 2011 and ends in 2013. Yu Chen is the Principal Investigator. Below is a summary of the work. The overall goal of this proposal is to investigate the clinical feasibility of a new minimally-invasive multi-modal optical imaging technology for the diagnosis of kidney diseases in vivo and in real time. Multi-modal optical imaging combining high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence imaging enables comprehensive assessment of kidney structural and functional parameters ...
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  Mentions: University of Maryland National Institutes of Health Yu Chen
17. Optical assessment of tissue anisotropy in ex vivo distended rat bladders
  
  Explore Linking to Scitation Content Aug 17 2012 Urology
  
  Microstructural remodelling in epithelial layers of various hollow organs, including changes in tissue anisotropy, are known to occur under mechanical distension and during disease processes. In this paper, we analyze how bladder distension alters wall anisotropy using polarized light imaging (followed by Mueller matrix decomposition). Optical retardance values of different regions of normal rat bladders under different distension pressures are derived. Then optical coherence tomography is used to measure local bladder wall thicknesses, enabling the calculation of the tissue birefringence maps as a measure of the tissue anisotropy. Selected two-photon microscopy is also performed to better understand the compositional origins ...
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  Mentions: University of Toronto I. Alex Vitkin
18. Encrustation of urologic double pigtail catheters—an ex vivo optical coherence tomography (OCT) study
  
  Explore SpringerLink Home Aug 7 2012 Urology
  
  This study aims to evaluate whether optical coherence tomography (OCT) using both the surface and the endoluminal technique is feasible to investigate the locations and degree of encrustation process in clinically used ureteral stents. After removal from patients, 14 polyurethane JJ stents were investigated. A fresh JJ served as a control. The external surfaces were examined using an endoscopic surface OCT whereas the intraluminal surfaces were investigated by an endoluminal radial OCT device. The focus was on detection of encrustation or crystalline sedimentation. In 12 female and two male patients, the median indwelling time of the ureteral catheter was 100 ...
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  Mentions: Ludwig Maximilians Universität München Herbert Stepp
19. Strategies to prevent progression of high-risk bladder cancer at initial diagnosis
  
  Explore LWW Online Jul 31 2012 Urology
  
  Purpose of review: As high-risk nonmuscle invasive bladder cancer (NMIBC) has a high propensity to recur and progress, the primary therapeutic goal in patients with high-risk NMIBC is the prevention or delay of disease recurrence and progression. Recent findings: For improving transurethral resection quality, new optical enhancement technology such as optical coherence tomography, photodynamic diagnosis and narrow band imaging might be considered because these emerging optical techniques may contribute to resection completeness and reduce the recurrence risk. Recent studies have confirmed that a second resection is associated with a lower risk of progression and cancer-related death. Although maintenance bacillus Calmette-Guerin ...
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20. New Optical Imaging Technologies for Bladder Cancer: Considerations and Perspectives
  
  Explore The Journal of Urology Jun 17 2012 Oncology , Urology
  
  Purpose Bladder cancer presents as a spectrum of different diatheses. Accurate assessment for individualized treatment depends on initial diagnostic accuracy. Detection relies on white light cystoscopy accuracy and comprehensiveness. Aside from invasiveness and potential risks, white light cystoscopy shortcomings include difficult flat lesion detection, precise tumor delineation to enable complete resection, inflammation and malignancy differentiation, and grade and stage determination. Each shortcoming depends on surgeon ability and experience with the technology available for visualization and resection. Fluorescence cystoscopy/photodynamic diagnosis, narrow band imaging, confocal laser endomicroscopy and optical coherence tomography address the limitations and have in vivo feasibility. They detect ...
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  Mentions: Stanford University
21. Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study
  
  Explore Wiley Online Library Jun 8 2012 Oncology , Urology
  
  Optical Coherence Tomography (OCT) was developed in the early 1990s for ophthalmological application and is currently widely accepted in ophthalmology for retinal imaging purposes. In kidneys, the first experiments were performed on transplant kidneys to investigate the ability of OCT to assess ischaemic damage of kidneys. An ex vivo pilot study on the ability of OCT to differentiate normal renal tissue from malignant renal tissue, showed positive results and here we present the results of the first in vivo experiment. The study shows for the first time that in vivo OCT is feasible and safe to perform in humans and ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
22. Kidney cancer: First in vivo study shows optical imaging can distinguish renal cancer from normal tissue
  
  Explore Nature Publishing Group Jun 2 2012 Oncology , Urology
  
  Optical coherence tomography (OCT) is a high-resolution light-based technique widely used in ophthalmology to image the retina in real time. Researchers in The Netherlands have transferred this technique to the human kidney, and now they report the first in vivo study of OCT for renal tumours in BJU International
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23. Differentiation Between Normal Renal Tissue and Renal Tumours Using Functional Optical Coherence Tomography: A Phase I In Vivo Human Study
  
  Explore Wiley Online Library May 14 2012 Urology
  
  No abstract provided.
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24. Enhanced thulium fiber laser lithotripsy using micro-pulse train modulation
  
  Explore Linking to Scitation Content Feb 28 2012 Urology
  
  The thulium fiber laser (TFL) is currently being studied as an alternative to the conventional holmium:YAG (Ho:YAG) laser for lithotripsy. The diode-pumped TFL may be electronically modulated to operate with variable parameters (e.g., pulse rate, pulse duration, and duty cycle) for studying the influence of pulse train mode on stone ablation rates. The TFL under study was operated at 1908 nm, 35-mJ pulse energy, and 500-μs pulse duration, in a train of 5 micro-pulses, with macro-pulse rates of 10 Hz, compared with conventional TFL operation at 10 to 50 Hz. TFL energy was delivered through 100-μm-core fibers ...
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  Mentions: University of North Carolina Nathaniel M. Fried
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