Popular Articles
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(5 articles) SUNY at Stony Brook
(4 articles) Ludwig Maximilians Universität München
(3 articles) Russian Academy of Sciences
(3 articles) George Washington University
(2 articles) RWTH Aachen University
(2 articles) Nizhny Novgorod State Medical Academy
(2 articles) Stanford University
(2 articles) Medical University of Vienna
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Combined image-processing algorithms for improved optical coherence tomography of prostate nerves
Explore Article SPIE Digital Library (Aug 20 2010)
Cavernous nerves course along the surface of the prostate gland and are responsible for erectile function. These nerves are at risk of injury during surgical removal of a cancerous prostate gland. In this work, a combination of segmentation, denoising, and edge detection algorithms are applied to time-domain optical coherence tomography (OCT) images of rat prostate to improve identification of cavernous nerves. First, OCT images of the prostate are segmented to differentiate the cavernous nerves from the prostate gland. Then, a locally adaptive denoising algorithm using a dual-tree complex wavelet transform is applied to reduce speckle noise. Finally, edge detection is ...
Comment on Article Mentions: Nathaniel M. Fried Shahab Chitchian Johns Hopkins University
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Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography
Explore Article The Journal of Urology (Aug 17 2010)
Purpose: We examined the usefulness of 3-dimensional optical coherence tomography to enhance the diagnosis of urothelial carcinoma in situ.Materials and Methods: By expressing SV40T antigen with uroplakin II promoter, carcinoma in situ readily develops in SV40T transgenic mice at about ages 8 to 20 weeks and then frank high grade papillary carcinoma develops in bladder epithelium. We examined 10 control and 40 SV40T mice during weeks 8 to 20 after birth by parallel en face white light imaging and 3-dimensional optical coherence tomography, and compared results with histology findings. We applied quantitative analysis of computer aided detection to 3-dimensional tomography ...
Comment on Article Mentions: SUNY at Stony Brook Yingtian Pan
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The origins of urothelial carcinoma
Explore Article Expert Reviews (Jun 17 2010)
Expert Review of Anticancer Therapy , June 2010, Vol. 10, No. 6, PaIt is now widely believed that there are two major pathways for urothelial carcinogenesis. One pathway usually involves mutation of FGF receptor 3 and gives rise to low-grade papillary tumors that frequently recur but seldom invade. By contrast, high-grade urothelial malignancies, including high-grade papillary urothelial carcinoma and urothelial carcinoma in situ (CIS) usually exhibit deletions or mutations of TP53. Urothelial CIS is the most likely precursor of high-grade invasive bladder cancer. It is a ‘flat lesion’ that may be relatively inconspicuous at cystoscopy, or even endoscopically undetectable. The ...
Comment on Article Mentions: Case Western Reserve University Indiana University
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Exclusive report from the International Society for the Study of Bladder Pain Syndrome (ESSIC) 8th Annual Meeting
Explore Article UroToday (May 27 2010)
Dr. Zaitcev from Moscow discussed a new tool that may help to identify the bladder lesions of BPS. He used optical coherence tomography in 21 women with Hunner’s lesions who underwent bladder distention under anesthesia. Optical coherence tomography is a novel method that can be used to construct cross-sectional images of tissue microstructure with high spatial resolution. It measures optical scattering of light by comparing the backscattered or back reflected light signal to a controlled reference signal. The principle is similar to B-mode ultrasound, except light is the medium rather than sound. In all cases, optical coherence tomograpy allowed visualization ...
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Tissue-mimicking bladder wall phantoms for evaluating acoustic radiation force-optical coherence elastography systems
Explore Article Scitation (May 8 2010)
Purpose: Acoustic radiation force–optical coherence elastography (ARF-OCE) systems are novel imaging systems that have the potential to simultaneously quantify and characterize the optical and mechanical properties of in vivo tissues. This article presents the construction of bladder wall phantoms for use in ARF-OCE systems. Mechanical, acoustic, and optical properties are reported and compared to published values for the urinary bladder. Methods: The phantom consisted of 0.2000±0.0089 and 6.0000±0.2830 µm polystyrene microspheres (Polysciences Inc., Warrington, PA, Catalog Nos. 07304 and 07312), 7.5±1.5 µm copolymer microspheres composed of acrylonitrile and vinylidene chloride, (Expancel, Duluth, GA, Catalog No. 461 DU 20), and bovine ...
Comment on Article Mentions: George Washington University Jason M. Zara
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Optical Coherence Tomography of Human Kidney
Explore Article The Journal of Urology (Mar 18 2010)
Purpose To determine histopathological status of living human kidneys in real time and a noninvasive fashion would be a significant advancement in renal disease diagnosis. Recently we reported that optical coherence tomography has the requisite high spatial resolution to noninvasively determine histopathological changes in rodent kidneys with μm scale resolution. We established whether optical coherence tomography could 1) effectively penetrate the connective tissue capsule surrounding human kidneys, 2) provide a global survey of the human renal surface and 3) determine histopathological changes in human renal microstructure. Materials and Methods Using a high speed optical coherence tomography system equipped with a ...
Comment on Article Mentions: University of Maryland Thorlabs Alex E. Cable
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Optical Coherence Tomography in the Kidney: A Step Toward Echo Microscopy
Explore Article The Journal of Urology (Mar 16 2010)
Optical coherence tomography (OCT) can present noninvasive cross-sectional images of internal tissue microstructure by measuring their optical reflections of a light beam of super luminescent diodes. Recently, swept laser has been used as a light source and has achieved high speed and resolution images with 1 to 15 μm resolution. The high resolution OCT imaging is performed in a way similar to the ultrasonic echo imaging but it uses the echo of lasers with extremely short pulses (femtosecond lasers) with 100 times finer resolution than ultrasound echo, so that OCT can be a step toward the development of laser echo ...
Comment on Article Mentions: University of Tokyo
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Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia
Explore Article SPIE Digital Library (Mar 2 2010)
We consider the cross-polarization OCT (CP OCT) that is focused on comparison of images resulting from cross-polarization and co-polarization scattering simultaneously. This technique provides information about microstructural and biochemical alterations in depolarizing tissue components (collagen). We found that mature type I collagen gives a strong signal in orthogonal polarization. CP OCT images of benign inflammatory processes always feature signal in orthogonal polarization, with layers and borders persisting to be well defined. In the presence of precancerous alterations, signal in orthogonal polarization is available in the image but it is irregular, disappearing in some areas. A CP OCT image of bladder ...
Comment on Article Mentions: Nizhny Novgorod State Medical Academy Valentin M. Gelikonov Elena V. Zagaynova
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Near-IR optical properties of canine prostate tissue using oblique-incidence reflectometry
Explore Article SPIE Digital Library (Mar 2 2010)
Optical imaging systems utilizing near-infrared light sources such as optical coherence tomography (OCT) have recently been used for imaging the prostate gland. However, the optimal wavelength for deep imaging of the prostate has yet to be determined. The objective of this study is to determine the optimal near-infrared wavelength for OCT imaging of the prostate using a system that has the potential to be used in an in vivo model. An obliqueincidence single point measurement technique using a normal-detector scanning system was implemented to determine the absorption (µa) and reduced scattering coefficients (µ's) of fresh canine prostate tissue, ex vivo, ...
Comment on Article Mentions: Nathaniel M. Fried Shahab Chitchian
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Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
Explore Article SPIE Digital Library (Feb 16 2010)
The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min. The therapeutical ...
Comment on Article Mentions: Nizhny Novgorod State Medical Academy Vladislav A. Kamensky Russian Academy of Sciences
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Optical coherence tomography of the upper urinary tract: Review of initial experience ex vivo and in vivo
Explore Article ScienceDirect (Feb 3 2010)
Diagnostic imaging of the upper urinary tract is a cumbersome process that involves a multitude of different imaging modalities, including ultrasonography, conventional radiography, X-ray fluoroscopy (retrograde and antegrade ureteropyelography), endoscopy (cystoscopy and ureterorenoscopy) without or with biopsy, multi-detector-row computed tomography (MDCT), and magnetic resonance imaging (MRI). However, these modalities leave a diagnostic gap because they cannot demonstrate different layers of the wall of the upper urinary tract. Recent research shows that catheter-based, intraluminal probes for optical coherence tomography (OCT) with near-infrared light provide cross-sectional images from within the lumen of the upper urinary tract that distinguish between the urothelium, lamina ...
Comment on Article Mentions: Siemens Ludwig Maximilians Universität München
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Bladder cancer: Optical coherence tomography improves UCC detection
Explore Article Nature Publishing Group (Jan 13 2010)
Targeted optical coherence tomography (OCT) in combination with hexaminolevulinate (HAL) fluorescence cystoscopy improves diagnostic accuracy in detecting urothelial cell carcinoma (UCC) of the bladder, report Schmidbauer and colleagues from the Medical University of Vienna.Fluorescence cystoscopy has been shown to significantly improve detection of UCC when used as an adjunct to white-light cystoscopy. -
UroToday Seminar on Optical coherence tomography
Explore Article UroToday (Dec 3 2009)
BETHESDA, MD, USA (UroToday.com) - In his presentation, Dr. Seth Lerner discussed optical coherence tomography (OCT), a high-resolution technology using near infrared light with a unique backscatter pattern of different tissue characteristics.
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On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading
Explore Article Scitation (Sep 16 2009)
has been recently demonstrated that the cellular details of bladder epithelium embedded in speckle noise can be uncovered with time-lapse ultrahigh-resolution optical coherence tomography (TL-uOCT) by proper time-lapse frame averaging that takes advantage of cellular micromotion in fresh biological tissue ex vivo. Here, spectral-domain 3-D TL-uOCT is reported to further improve the image fidelity, and new experimental evidence is presented to differentiate normal and cancerous nuclei of rodent bladder epithelia. Results of animal cancer study reveal that despite a slight overestimation (e.g., <10%) of nuclear size (DN) to histological evaluation, TL-uOCT is capable of distinguishing normal (DN7 µm) and cancerous ...Comment on Article Mentions: Yingtian Pan SUNY at Stony Brook
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Segmentation of optical coherence tomography images for differentiation of the cavernous nerves from the prostate gland
Explore Article SPIE Digital Library (Aug 25 2009)
The cavernous nerves course along the surface of the prostate and are responsible for erectile function. Improvements in identification, imaging, and visualization of the cavernous nerves during prostate cancer surgery may improve nerve preservation and postoperative sexual potency. Two-dimensional (2-D) optical coherence tomography (OCT) images of the rat prostate were segmented to differentiate the cavernous nerves from the prostate gland. To detect these nerves, three image features were employed: Gabor filter, Daubechies wavelet, and Laws filter. The Gabor feature was applied with different standard deviations in the x and y directions. In the Daubechies wavelet feature, an 8-tap Daubechies orthonormal ...Comment on Article Mentions: Nathaniel M. Fried Shahab Chitchian
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Great video Jim!
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Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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