1. Articles in category: Otolaryngology

    1-24 of 345 1 2 3 4 ... 13 14 15 »
    1. Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty

      Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty

      Objective measurement of the nasal valve region is valuable for the assessment of functional rhinoplasty surgical outcomes. Anatomical optical coherence tomography (aOCT) is an imaging modality that may be used to obtain real-time, quantitative, and volumetric scans of the nasal airway. We aim to evaluate if volumetric aOCT imaging is useful for the examination of the nasal valve region before and after functional rhinoplasty procedures. aOCT scans of the nasal valves were performed on four cadaveric heads before and after spreader graft and butterfly graft procedures. The resulting aOCT images were compared against video endoscopy images, and the segmented volumes ...

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      Mentions: Amy L. Oldenburg
    2. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      Massachusetts Eye and Ear Infirmary Receives a 2020 NIH Grant for $491,220 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

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    3. University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a 2020 NIH Grant for $710,479 for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    4. PhotoniCare Announces FDA Clearance for First-In-Class Technology for Imaging the Ear

      PhotoniCare Announces FDA Clearance for First-In-Class Technology for Imaging the Ear

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced that the U.S. Food & Drug Administration (FDA) has granted 510(k) clearance for its TOMi ™ Scope for non-invasive imaging of the middle ear. Using optical coherence tomography (OCT) high resolution depth imaging, TOMi Scope helps to determine the presence or absence of fluid in the middle ear and to characterize the fluid type. According to clinical guidelines, the presence of fluid in the middle ear is a primary indicator for determining infection. Designed to eliminate subjectivity and speculation, TOMi Scope allows physicians ...

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    5. Sensing high frequency sub-nanometer vibrations using optical coherence tomography with real-time profilometry of multiple inner layers

      Sensing high frequency sub-nanometer vibrations using optical coherence tomography with real-time profilometry of multiple inner layers

      A robust technique for vibration sensing using Optical Coherence Tomography is introduced, which can yield nanometer- and sub-nanometer-scale vibration measurements for multiple inner layers simultaneously, even with low signal to noise ratio (SNR) signals from low cost devices. Constructing a camera-based parallel spectral domain optical coherence tomography device with just 40 dB SNR, we demonstrate as proof-of-principle, how our technique can work with vibration amplitudes over three orders of magnitude, from hundreds of picometers to hundreds of nanometers. Our technique is unrestricted by the Nyquist sampling limit. This makes it suitable for measuring amplitudes of even MHz frequency vibrations which ...

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    6. PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition

      PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition

      PhotoniCare took home first place at the 7th Annual Insight Product Development 2019 HealthTECH Startup Competition. The annual competition, sponsored by Insight Innovation Center – Chicago, MATTER, and iBIO, brings together a mix of healthcare industry and community stakeholders. The program aims to achieve the following goals: Improve lives by bringing innovative health solutions to patients Encourage entrepreneurship in the healthcare industry Grow the medical innovation ecosystem Connect investors and corporations with early-stage companies The competition included 10 finalists, selected based on a competitive application process, which came together on November 14th in Chicago, Illinois, to each give a five-minute startup ...

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      Mentions: PhotoniCare
    7. The PhotoniCare team caps off a successful 2019 with a move to a new location

      The PhotoniCare team caps off a successful 2019 with a move to a new location

      2019 has been a very exciting AND BUSY year for the PhotoniCare team. In particular, the year has brought more growth and movement forward for the staff than ever before. Between funding agreements, opportunities for research studies, multiple industry trade shows, and more, the team has been busier than ever. If you’re just tuning in, here’s a snapshot of just a few of PhotoniCare’s 2019 highlights: Entered into an exclusive distribution agreement with Adachi Co., LTD , (Osaka, Japan) to commercialize the TOMi ™ Scope device throughout Japan. ( read more here ) Initiated a multi-site registered clinical study to evaluate ...

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      Mentions: PhotoniCare
    8. The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and neck mucosa. Previous work has utilized 2‐D OCT imaging which is limited to the evaluation of a small regions of interest generated frame by frame. OCT technology is capable of ...

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    9. Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

      Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

      Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging. Method. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images. Results. The middle ear microstructures such as ...

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    10. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...

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    11. High-resolution Imaging of the Human Cochlea through the Round Window by means of Optical Coherence Tomography

      High-resolution Imaging of the Human Cochlea through the Round Window by means of Optical Coherence Tomography

      The human cochlea is deeply embedded in the temporal bone and surrounded by a thick otic capsule, rendering its internal structure inaccessible for direct visualization. Clinical imaging techniques fall short of their resolution for imaging of the intracochlear structures with sufficient detail. As a result, there is a lack of knowledge concerning best practice for intracochlear therapy placement, such as cochlear implantation. In the past decades, optical coherence tomography (OCT) has proven valuable for non-invasive, high-resolution, cross-sectional imaging of tissue microstructure in various fields of medicine, including ophthalmology, cardiology and dermatology. There is an upcoming interest for OCT imaging of ...

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    12. The frequency limit of outer hair cell motility measured in vivo

      The frequency limit of outer hair cell motility measured in vivo

      Outer hair cells (OHCs) in the mammalian ear exhibit electromotility, electrically driven somatic length changes that are thought to mechanically amplify sound-evoked vibrations. For this amplification to work, OHCs must respond to sounds on a cycle-by-cycle basis even at frequencies that exceed the low-pass corner frequency of their cell membranes. Using in vivo optical vibrometry we tested this theory by measuring sound-evoked motility in the 13–25 kHz region of the gerbil cochlea. OHC vibrations were strongly rectified, and motility exhibited first-order low-pass characteristics with corner frequencies around 3 kHz– more than 2.5 octaves below the frequencies the OHCs ...

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    13. Compensation for the Influence of Fluctuations in the Distance to the Object During Noncontact Probing in Spectral Domain Optical Coherence Tomography

      Compensation for the Influence of Fluctuations in the Distance to the Object During Noncontact Probing in Spectral Domain Optical Coherence Tomography

      We propose and experimentally test a numerical method for correction of the influence of fluctuations in the distance to objects during noncontact probing in optical coherence tomography. The method is based on the analysis of phase shifts of the neighboring scans, which are due to microscale displacements, and further compensation for these displacements by using phasefrequency correction in the spectral domain. Unlike the known correlation methods, the proposed method does not distort the represented shape of the object surface. Its operability is demonstrated in model experiments in the cases of harmonic and random types of the motion of the scattering ...

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    14. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface as well as the complex 3D anatomical shape. Previous studies indicate that changes in airway histopathology can be found in the OCT image almost immediately after inhalation of smoke and ...

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    15. Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography

      Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography

      Optical coherence tomography (OCT) has a micro-resolution with a penetration depth of about 2 mm and field of view of about 10 mm. This makes OCT well suited for analyzing the anatomical and internal structural assessment of the middle ear. To study the vibratory motion of the tympanic membrane (TM) and its internal structure, we developed a phase-resolved Doppler OCT system using Kasai’s autocorrelation algorithm. Doppler optical coherence tomography is a powerful imaging tool which can offer the micro-vibratory measurement of the tympanic membrane and obtain the micrometer-resolved cross-sectional images of the sample in real-time. To observe the relative ...

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    16. Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis

      Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis

      Subglottic stenosis (SGS) is a challenging disease to diagnose in neonates. Long-range optical coherence tomography (OCT) is an optical imaging modality that has been described to image the subglottis in intubated neonates. A major challenge associated with OCT imaging is the lack of an automated method for image analysis and micrometry of large volumes of data that are acquired with each airway scan (1 to 2 Gb). We developed a tissue segmentation algorithm that identifies, measures, and conducts image analysis on tissue layers within the mucosa and submucosa and compared these automated tissue measurements with manual tracings. We noted small ...

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    17. Method and apparatus for obtaining a three-dimensional map of tympanic membrane thickness

      Method and apparatus for obtaining a three-dimensional map of tympanic membrane thickness

      Methods and apparatus for combining a low coherence interferometry (LCI) technique for single-point thickness measurement with videootoscopy for recording the image of a tissue such as the tympanic membrane (TM). TM thickness distribution maps are obtained by mapping the LCI imaging sites onto an anatomically accurate wide-field image of the TM, generated by mosaicking a sequence of multiple small field-of-view video-otoscopy images.

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    18. Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics

      Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics

      Voice disorders affect a large number of adults in the United States, and their clinical evaluation heavily relies on laryngeal videostroboscopy, which captures the medial-lateral and anterior-posterior motion of the vocal folds using stroboscopic sampling. However, videostroboscopy does not provide direct visualization of the superior-inferior movement of the vocal folds, which yields important clinical insight. In this paper, we present a novel technology that complements videostroboscopic findings by adding the ability to image the coronal plane and visualize the superior-inferior movement of the vocal folds. The technology is based on optical coherence tomography, which is combined with videostroboscopy within the ...

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    19. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system

      Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system

      We have developed a highly phase stable optical coherence tomography and vibrometry system that attaches directly to the accessory area of a surgical microscope common to both the otology clinic and operating room. Careful attention to minimizing sources of phase noise has enabled a system capable of measuring vibrations of the middle ear with a sensitivity of < 5 pm in an awake human patient. The system is shown to be capable of collecting a wide range of information on the morphology and function of the ear in live subjects, including frequency tuning curves below the hearing threshold, maps of tympanic ...

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    20. UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT for In-vivo identification of Bacterial Otitis Media

      UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT  for In-vivo identification of Bacterial Otitis Media

      University of Illinois at Urbana Champaign Receives a 2019 NIH Grant for $648,154 for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-vivo identification of Bacterial Otitis Media. The principal investigator is Stephen Boppart. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Otitis media (middle ear infection) is a highly prevalent disease, especially in young children. It has been documented that more than 75% of children will have at least one episode of otitis media (OM) by age 3, and many children will have recurrent or chronic OM ...

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    21. Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)

      Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)

      Currently, research is being conducted on single tone sound transduction within the auditory portion of the inner ear, the cochlea [1]. The study of cochlear mechanics in large rodents has provided important insight into cochlear function [1]. Additionally, multi-tone stimuli can provide a new perspective in vibrometric analyses that could be used in audiometry as a measure of hearing loss for patients in terms of both magnitude and their unique frequency envelope. Therefore, the proposed study was aimed to test the recent implementation of multitone calibration into an existing python program, PyVib2, which was used during Optical Coherence Tomography (OCT ...

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    22. PhotoniCare Looks Behind Ear Drums to Help Diagnose Ear Infections

      PhotoniCare Looks Behind Ear Drums to Help Diagnose Ear Infections

      Middle ear infections are one of the most common reasons for visits to the pediatrician. However, because the middle ear is hidden from view by the ear drum, physicians must diagnose based on symptoms and a limited physical exam — and when patients have ambiguous or borderline symptoms, accurate diagnosis can be challenging. PhotoniCare’s TOMi Scope uses near-infrared light waves to provide 3D views beyond the ear drum into the middle ear, allowing physicians to visualize and better diagnose middle ear infections. Co-founder and CEO Ryan Shelton, Ph.D. answered a few of our questions about his company’s beginnings ...

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    23. In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope

      In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope

      This study combined a previously developed optical system with two additional key elements: a supercontinuum light source characterized by high output power and an analytical technique that effectively extracts interference signals required for improving the detection limit of vibration amplitude. Our system visualized 3D tomographic images and nanometer scale vibrations in the cochlear sensory epithelium of a live guinea pig. The transverse- and axial-depth resolution was 3.6 and 2.7 µm, respectively. After exposure to acoustic stimuli of 21–25 kHz at a sound pressure level of 70–85 dB, spatial amplitude and phase distributions were quantified on a ...

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    24. Cracking the cochlea: U-M team creates mathematical model of ear’s speech center

      Cracking the cochlea: U-M team creates mathematical model of ear’s speech center

      New research paves the way for modeling the transduction of speech and music at the cochlear level. Until now, the part of the ear that processes speech was poorly reflected in computer models, but University of Michigan researchers have figured out the math that describes how it works. It could help improve hearing tests and devices that restore some hearing to the deaf. Inside the ear, a snail-shaped organ called the cochlea takes in pressure information from the eardrum and turns it into nerve impulses that are sent to the brain. A full understanding of how this tube-like structure does ...

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    1-24 of 345 1 2 3 4 ... 13 14 15 »
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