1. Articles in category: Otolaryngology

    1-24 of 317 1 2 3 4 ... 12 13 14 »
    1. Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives a 2019 NIH Grant for $ 505,632 for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance. The principal investigator is Jesung Park. The program began in 2016 and ends in 2021. Below is a summary of the proposed work.

      Sensorineural hearing loss (SNHL) is a source of significant morbidity and in isolated cases is irreversible. Most cases of SNHL are associated with damage or loss of cochlear hair cells. The diagnosis of SNHL is based primarily on audiometric testing as the inner ear cannot be “biopsied” without causing profound hearing loss. Contemporary ...

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    2. Quality Assessment of Tympanoplasty by Means of Endoscopic Optical Coherence Tomography

      Quality Assessment of Tympanoplasty by Means of Endoscopic Optical Coherence Tomography

      Introduction: The endoscopic optical coherence tomography (eOCT) allows the direct, contactless representation and evaluation of the morphology and oscillation behaviour of the tympanic membrane and adjoining tympanic cavity content. After further development of the measuring technology, the eOCT will be able to be used in vivo for the assessment of tympanoplasty results. Materials and Methods: The eOCT was applied to 10 patients after a tympanoplasty with an intact ossicular chain and to 10 patients after a Type III tympanoplasty. The measurement data of the morphology – especially the thickness – and oscillation behaviour of the tympanic membrane and the prosthesis coupling to ...

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    3. Endoscopic Optical Coherence Tomography in Diagnostics of Otosclerosis

      Endoscopic Optical Coherence Tomography in Diagnostics of Otosclerosis

      Introduction: Endoscopic Optical Coherence Tomography (eOCT) enables both high-resolution contact-free 3D-imaging of the tympanic membrane and spatial and frequency-resolved oscillation measurement via Doppler-OCT. Thus it is possible to detect causes of conduction hearing loss. In case of otosclerosis, changes in oscillation amplitude at the umbo had been showed via Laser-Doppler-Vibrometry. Material and Methods: The eOCT system utilizes a swept source laser with a wave length around 1300nm. Field-of-view and working distance are 10 mm. Sound stimulus was a Chirp in the frequency range between 0.5 and 5 kHz at 95 dB. Morphological and functional measurements were done on 12 ...

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    4. Biomedical optical techniques for intracochlear cellular imaging (Thesis)

      Biomedical optical techniques for intracochlear cellular imaging (Thesis)

      Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Under this situation, using suitable imaging techniques would be extremely helpful in detecting disease and diagnosing pathologies of the inner ear. However, cochlear small size and encasement in bone provide challenging obstacles, preventing visualization of intracochlear microanatomy using standard clinical imaging modalities. In this thesis, we explore optical techniques to image inner ear cells and we report an ...

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    5. University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives a 2019 NIH Grant for $215,469 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex ...

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    6. PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc., a medical device company headquartered in Champaign, Illinois, announces successful initiation of a multi-site registered clinical study to evaluate the imaging capabilities and image analysis performance of the PhotoniCare TOMi Scope. Children’s National Health System (Washington, D.C.) is the first initiated of two clinical sites involved in this registered multi-site clinical study, along with Carle Foundation Hospital (Urbana, Illinois). The study is led by Dr. Diego Preciado, Children’s National, and Dr. Ryan Porter, Carle Hospital, along with a team of recognized otitis media experts at both clinical sites. This multi-center study plans to enroll a ...

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    7. University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives a 2019 NIH Grant for $487,053 for Understanding Otoacoustic Emissions. The principal investigator is Christopher Shera. The program began in 1999 and ends in 2024. Below is a summary of the proposed work. Realizing the potential of otoacoustic emissions (OAEs) as noninvasive probes of cochlear function requires understanding the physical and physiological mechanisms that generate and shape these sounds. To address important unresolved issues of cochlear mechanics while improving our understanding of OAE generation, we propose three aims involving innovative theoretical modeling rigorously tested by experimental measurements. The first Aim studies the action of ...

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    8. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives a 2019 NIH Grant for $408,735 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion ...

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    9. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2019 NIH Grant for $63,746 for Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for ...

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    10. University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives a 2019 NIH Grant for $670,541 for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes. The principal investigator is Brian Applegate. The program began in 2019 and ends in 2022. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin ...

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    11. Automated classification platform for the identification of otitis media using optical coherence tomography

      Automated classification platform for the identification of otitis media using optical coherence tomography

      The diagnosis and treatment of otitis media (OM), a common childhood infection, is a significant burden on the healthcare system. Diagnosis relies on observer experience via otoscopy, although for non-specialists or inexperienced users, accurate diagnosis can be difficult. In past studies, optical coherence tomography (OCT) has been used to quantitatively characterize disease states of OM, although with the involvement of experts to interpret and correlate image-based indicators of infection with clinical information. In this paper, a flexible and comprehensive framework is presented that automatically extracts features from OCT images, classifies data, and presents clinically relevant results in a user-friendly platform ...

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    12. Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Objectives Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. This study describes UVFP microanatomy and identifies possible vocal fold atrophy using OCT. Methods Three UVFP patients (ages 1, 11, and 17 years) underwent bilateral OCT imaging using a ...

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    13. Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Hypothesis: Ears with otosclerotic stapes fixation will exhibit lower-than-normal levels of ossicular mobility as measured by Optical Coherence Tomography Doppler Vibrometry (OCT-DV). Background: OCT-DV measures the vibration of middle ear structures in response to sound non-invasively through the intact tympanic membrane. This allows, in particular, direct measurement of the vibration at the lenticular process of the incus which is expected to be lower in patients with otosclerotic stapes fixation. Methods: OCT-DV was performed on ears presumptively diagnosed with otosclerosis (n = 13) and a group of normal control ears (n = 42). Displacement was measured at the umbo and the lenticular process ...

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    14. Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives a 2019 NIH Grant for $428,832 for Auditory Mechanics and Cochlear Amplification. The principal investigator is Elizabeth Olson. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. Sound input to the inner ear (cochlea) causes a frequency-segregated wave-pattern of sensory tissue motion that conveys sound information to the auditory neurons, leading to hearing. A currently untreatable aspect of hearing impairment is the deterioration of the cochlea's ability to sharply segregate sound by frequency. The cochlea's healthy frequency tuning is largely provided by the cochlear amplifier, an ...

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    15. lntraoperative Imaging of Pediatric Unilateral Vocal Fold Paralysis Using Optical Coherence Tomography

      lntraoperative Imaging of Pediatric Unilateral Vocal Fold Paralysis Using Optical Coherence Tomography

      Objectives Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. This study describes UVFP microanatomy and identifies possible vocal fold atrophy using OCT. Methods Three UVFP patients (ages 1, 11, and 17 years) underwent bilateral OCT imaging using a ...

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    16. MEEI Receives NIH Grant for Measuring and Modeling The Cochlear Motions that Drive The Inner and Outer Hair Cells and Produce Otoacoustic Emissions

      MEEI Receives NIH Grant for Measuring and Modeling The Cochlear Motions that Drive The Inner and Outer Hair Cells and Produce Otoacoustic Emissions

      Massachusetts Eye and Ear Infirmary Receives a 2019 NIH Grant for $540,156 for Measuring and Modeling The Cochlear Motions that Drive The Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. The program began in 2007 and ends in 2022. Below is a summary of the propose work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in ...

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    17. Using OCT to Watch an Ear Hear

      Using OCT to Watch an Ear Hear

      A research team led by OSA Fellow Seok-Hyun Yun at the Wellman Center for Photomedicine at Massachusetts General Hospital, USA, reports using a form of optical coherence tomography (OCT) to capture 3-D anatomical and vibrational images of ossicles—tiny bones within the middle ear—as they move in response to sound (Biomed. Opt. Express, doi: 10.1364/BOE.9.005489 ). The imaging method, which they named OCT vibrography, uses OCT phase-synchronized with a range of high-frequency sound stimuli. In demonstrations with a chinchilla ear model, the researchers used OCT vibrography to observe a previously unknown mode of ossicular motion at ...

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    18. Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane

      Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane

      An endoscopic optical coherence tomography (OCT) system with a wide field-of-view of 8 mm is presented, which combines the image capability of endoscopic imaging at the middle ear with the advantages of functional OCT imaging, allowing a morphological and functional assessment of the human tympanic membrane. The endoscopic tube has a diameter of 3.5 mm and contains gradient-index optics for simultaneous forward-viewing OCT and video endoscopy. The endoscope allows the three-dimensional visualization of nearly the entire tympanic membrane. In addition, the oscillation of the tympanic membrane is measured spatially resolved and in the frequency range between 500 Hz and ...

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    19. Clinical Utility of Intraoperative Tympanomastoidectomy Assessment Using a Surgical Microscope Integrated with an Optical Coherence Tomography

      Clinical Utility of Intraoperative Tympanomastoidectomy Assessment Using a Surgical Microscope Integrated with an Optical Coherence Tomography

      Significant technical and optical advances are required for intraoperative optical coherence tomography (OCT) to be utilized during otological surgeries. Integrating OCT with surgical microscopy makes it possible to evaluate soft tissue in real-time and at a high resolution. Herein, we describe an augmented-reality, intraoperative OCT/microscope system with an extended working distance of 280 mm, providing more space for surgical manipulation than conventional techniques. We initially performed ex vivo experiments to evaluate system performance. In addition, we validated the system by performing preliminary clinical assessments of tympanomastoidectomy outcomes in six patients with chronic otitis media. The system evaluated residual inflammation ...

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    20. Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography

      Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography

      The sound-driven vibration of the tympanic membrane and ossicular chain of middle-ear bones is fundamental to hearing. Here we show that optical coherence tomography in phase synchrony with a sound stimulus is well suited for volumetric, vibrational imaging of the ossicles and tympanic membrane. This imaging tool — OCT vibrography — provides intuitive motion pictures of the ossicular chain and how they vary with frequency. Using the chinchilla ear as a model, we investigated the vibrational snapshots and phase delays of the manubrium, incus, and stapes over 100 Hz to 15 kHz. The vibrography images reveal a previously undescribed mode of motion ...

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    21. Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry

      Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry

      There is indirect evidence that the mammalian cochlea in the low-frequency apical and the more commonly-studied high-frequency basal regions function in fundamentally different ways. Here, we directly tested this hypothesis by measuring sound-induced vibrations of the organ of Corti (OoC) at three turns of the gerbil cochlea using volumetric optical coherence tomography vibrometry (VOCTV), an approach that permits non-invasive imaging through the bone. In the apical turn, there was little frequency selectivity and the displacement-versus-frequency curves had low-pass filter characteristics with a corner frequency of ~0.5-0.9 kHz. The vibratory magnitudes increased compressively with increasing stimulus intensity at all ...

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    22. Optical coherence tomography (OCT) findings in obstructive sleep apnea

      Optical coherence tomography (OCT) findings in obstructive sleep apnea

      We have read the article by Mentek et al., however, we believe some discussion would be of benefit [1]. The authors describe vascular disorders of the retina and optic nerve in patients affected by obstructive sleep apnea (OSA). When reviewing results of eye tests in this disease it is necessary to mention that OSA itself presents alterations in particular ophthalmic examinations.

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    23. Optical Coherence Tomography as an Oral Cancer Screening Adjunct in a Low Resource Settings

      Optical Coherence Tomography as an Oral Cancer Screening Adjunct in a Low Resource Settings

      Oral cancer is the sixth most common cancer worldwide, predominantly seen in low and middle-income countries (LMIC). Two thirds of all cases are detected at a late stage when prognosis and treatment outcomes are poor. Oral lesions are commonly detected by visual inspection, followed by invasive surgical biopsy and time consuming histopathological analysis. Optical Coherence Tomography (OCT), a minimally invasive tomographic imaging technology, can be used to non-invasively identify premalignant or malignant change in the oral mucosa. In this study, a mobile OCT imaging system was designed, constructed and tested for its performance as a point-of-care oral diagnostic device. Twenty ...

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