Otolaryngology -Optical Coherence Tomography News

Articles in category: Otolaryngology

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1. Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media
  
  Explore Wiley Online Library Jan 21 2015 Otolaryngology
  
  Objective/Hypothesis In this study, optical coherence tomography (OCT) is used to noninvasively and quantitatively determine tympanic membrane (TM) thickness and the presence and thickness of any middle-ear biofilm located behind the TM. These new metrics offer the potential to differentiate normal, acute, and chronic otitis media (OM) infections in pediatric subjects. Study Design Case series with comparison group. Methods The TM thickness of 34 pediatric subjects was acquired using a custom-built, handheld OCT system following a traditional otoscopic ear exam. Results Overall thickness (TM and any associated biofilm) was shown to be statistically different for normal, acute, and chronic ...
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  Mentions: National Institutes of Health Stephen A. Boppart University of Illinois at Urbana-Champaign
2. Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography
  
  Explore AME Publishing Company Jan 18 2015 Otolaryngology , Probes
  
  Background: Otitis media (OM), an infection in the middle ear, is extremely common in the pediatric population. Current gold-standard methods for diagnosis include otoscopy for visualizing the surface features of the tympanic membrane (TM) and making qualitative assessments to determine middle ear content. OM typically presents as an acute infection, but can progress to chronic OM, and after numerous infections and antibiotic treatments over the course of many months, this disease is often treated by surgically inserting small tubes in the TM to relieve pressure, enable drainage, and provide aeration to the middle ear. Diagnosis and monitoring of OM is ...
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  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Ryan L. Shelton
3. Optical coherence tomography and autofluorescence imaging of human tonsil
  
  Explore PLoS ONE Dec 30 2014 Otolaryngology
  
  For the first time, we present co-registered autofluorescence imaging and optical coherence tomography (AF/OCT) of excised human palatine tonsils to evaluate the capabilities of OCT to visualize tonsil tissue components. Despite limited penetration depth, OCT can provide detailed structural information about tonsil tissue with much higher resolution than that of computed tomography, magnetic resonance imaging, and Ultrasound. Different tonsil tissue components such as epithelium, dense connective tissue, lymphoid nodules, and crypts can be visualized by OCT. The co-registered AF imaging can provide matching biochemical information. AF/OCT scans may provide a non-invasive tool for detecting tonsillar cancers and for ...
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  Mentions: University of British Columbia British Columbia Cancer Agency Hamid Pahlevaninezhad
4. Intraoperative long range optical coherence tomography as a novel method of imaging the pediatric upper airway before and after adenotonsillectomy
  
  Explore ijporlonline.com Dec 7 2014 Otolaryngology
  
  Background/Objectives While upper airway obstruction is a common problem in the pediatric population, the first-line treatment, adenotonsillectomy, fails in up to 20% of patients. The decision to proceed to surgery is often made without quantitative anatomic guidance. We evaluated the use of a novel technique, long-range optical coherence tomography (LR-OCT), to image the upper airway of children under general anesthesia immediately before and after tonsillectomy and/or adenoidectomy. We investigated the feasibility of LR-OCT to identify both normal anatomy and sites of airway narrowing and to quantitatively compare airway lumen size in the oropharyngeal and nasopharyngeal regions pre- and ...
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  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
5. Intraoperative optical coherence tomography imaging to identify parathyroid glands
  
  Explore Home - Springer Dec 5 2014 Otolaryngology
  
  Objective Optical coherence tomography (OCT) is a non-invasive high-resolution imaging technique that permits characterization of microarchitectural features in real time. Previous ex vivo studies have shown that the technique is capable of distinguishing between parathyroid tissue, thyroid tissue, lymph nodes, and adipose tissue. The purpose of this study was to evaluate the practicality of OCT during open and minimally invasive parathyroid and thyroid surgery. Methods During parathyroid and thyroid surgery, OCT images were generated from parathyroid glands, thyroid tissue, lymph nodes, and adipose tissue. The images were immediately assessed by the operating team using the previously defined criteria. Second, the ...
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  Mentions: Herbert Stepp Ludwig Maximilian University of Munich Julia Gallwas
6. Long-range Fourier domain optical coherence tomography of the pediatric subglottis
  
  Explore ijporlonline.com Nov 29 2014 Otolaryngology
  
  Background Acquired subglottic stenosis (SGS) most commonly results from prolonged endotracheal intubation and is a diagnostic challenge in the intubated child. At present, no imaging modality allows for in vivo characterization of subglottic microanatomy to identify early signs of acquired SGS while the child remains intubated. Fourier domain optical coherence tomography (FD-OCT) is a minimally invasive, light-based imaging modality which provides high resolution, three dimensional (3D) cross-sectional images of biological tissue. We used long-range FD-OCT to image the subglottis in intubated pediatric patients undergoing minor head and neck surgical procedures in the operating room. Methods A long-range FD-OCT system and ...
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  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
7. Method and apparatus for cochlear implant surgery
  
  Explore uspto.gov Nov 11 2014 Otolaryngology , Patents
  
  A system for cochlear implant surgery includes a reference device having at least a portion adapted to be arranged at a fixed position relative to a cochlea of a patient to provide a reference position, an image acquisition and processing system adapted to acquire an image of at least a portion of the cochlea relative to the reference position and to provide an implant plan based at least partially on the acquired image, and an implant system adapted for implanting a cochlear lead array using the reference position and the implant plan.
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8. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear
  
  Explore opticsinfobase.org Oct 21 2014 Otolaryngology
  
  Phase-sensitive optical coherence tomography (PhOCT) offers exquisite sensitivity to mechanical vibration in biological tissues. There is growing interest in using PhOCT for imaging the nanometer scale vibrations of the ear in animal models of hearing disorders. Swept-source-based systems offer fast acquisition speeds, suppression of common mode noise via balanced detection, and good signal roll-off. However, achieving high phase stability is difficult due to nonlinear laser sweeps and trigger jitter in a typical swept laser source. Here, we report on the initial application of a Vernier-tuned distributed Bragg reflector (VT-DBR) swept laser as the source for a fiber-based PhOCT system. The ...
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  Mentions: Stanford University Texas A&M University Brian E. Applegate
9. Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale
  
  Explore Hindawi Publishing Corporation Oct 9 2014 Otolaryngology
  
  Lasers have been proven to be precise tools for bone ablation. Applying no mechanical stress to the patient, they are potentially very suitable for microsurgery on fragile structures such as the inner ear. However, it remains challenging to control the laser-bone ablation without injuring embedded soft tissue. In this work, we demonstrate a closed-loop control of a short-pulsed CO 2 laser to perform laser cochleostomy under the monitoring of an optical coherence tomography (OCT) system. A foresighted detection of the bone-endosteum-perilymph boundary several hundred micrometers before its exposure has been realized. Position and duration of the laser pulses are planned ...
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  Mentions: Robert A. Huber Wolfgang Wieser University of Lübeck
10. The role of physics in inner-ear physiology and auditory perception
  
  Explore Scitation Sep 23 2014 Otolaryngology
  
  Auditory analysis of acoustical stimuli has mainly been connected with Fourier analysis. This touches the basic link between auditory perception and the operation of the hearing organs, namely, physics and mathematics. This relation has amply been demonstrated by the work and ideas of Georg von Békésy. Later, the healthy cochlea (inner ear) was found to contain amplifying elements that boost frequency selectivity. Associated with this there is a pronounced nonlinearity. Furthermore, the ear does not only absorb and process sounds, it also emits sound waves. Mathematical models of all these processes must contain subsets serving them all, a ...
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11. Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography
  
  Explore oto.sagepub.com Sep 9 2014 Otolaryngology
  
  Objectives: (1) Show the possibility of using optical coherence tomography (OCT) to visualize the internal structure of the vestibule and semicircular canals with the bony capsule intact. (2) Study the effect of the decalcification. OCT is a nondestructive imaging modality that uses infrared light as it penetrates turbid biological tissue. Previously, OCT has been successfully used to visualize inside the cochlea in normal and abnormal inner ears. Methods: The OCT system, OCS-1300SS (Thorlabs, Inc, NJ) with a central wavelength of 1300 nm and a theoretical axial resolution of 9 µm, was employed for image acquisition. Normal and Slc26a4 mutant mice ...
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  Mentions: Thorlabs Thorlabs OCT Imaging Systems
12. First Use of Long-Range Optical Coherence Tomography to Image Airway Structure in Awake Children
  
  Explore oto.sagepub.com Sep 9 2014 Otolaryngology
  
  Objectives: Identifying the appropriate operation(s) for children with sleep-disordered breathing (SDB) remains a challenge, and current imaging modalities have major shortcomings. We have pioneered the use of long-range optical coherence tomography (LR-OCT) to provide real-time images of the upper airway (UA) during sleep and wakefulness. Here we present our first use of LR-OCT to image the UA of awake children. (1) Understand how LR-OCT produces high-resolution structural images by acting as an optical range-finder. (2) Recognize how LR-OCT can identify strictures and real-time collapse of the airway. Methods: This study builds upon our experience using LR-OCT to image 58 ...
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  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
13. Experimental and Modeling Study of Human Tympanic Membrane Motion in the Presence of Middle Ear Liquid
  
  Explore Home - Springer Aug 12 2014 Otolaryngology
  
  Vibration of the tympanic membrane (TM) has been measured at the umbo using laser Doppler vibrometry and analyzed with finite element (FE) models of the human ear. Recently, full-field TM surface motion has been reported using scanning laser Doppler vibrometry, holographic interferometry, and optical coherence tomography. Technologies for imaging human TM motion have the potential to lead to using a dedicated clinical diagnosis tool for identification of middle ear diseases. However, the effect of middle ear fluid (liquid) on TM surface motion is still not clear. In this study, a scanning laser Doppler vibrometer was used to measure the full-field ...
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14. Do You Hear That? It Sounds Like a Technology Breakthrough
  
  Explore Community Jul 15 2014 Otolaryngology
  
  The inner workings of the ear have been a mystery for decades. However, that’s all about to change thanks to the efforts of a team of researchers determined to shed some light on the hearing process. Researchers from Stanford University and Texas A&M are working on mapping the tissues of the cochlea, the portion of the inner ear responsible for hearing. To map the cochlea, they used a technique known as optical coherence tomography (OCT) on animal models. OCT is similar to ultrasound but generates very high-resolution images, along with terabytes of measurement data. This data must be ...
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  Mentions: Stanford University Texas A&M University
15. High-resolution images of inner ear could lead to new hearing loss therapies
  
  Explore College of Engineering Jul 8 2014 Otolaryngology
  
  Understanding how hearing works has long been hampered by challenges associated with seeing inside the inner ear, but technology being developed by a team of researchers that includes a biomedical engineer from Texas A&M University is generating some of the most detailed images of the inner ear to date while offering new insight into the mechanics of hearing that could lead to new therapies for hearing loss. Employing a technique that generates high-resolution, three-dimensional images, Brian Applegate, associate professor in the Department of Biomedical Engineering at Texas A&M, and colleagues from Stanford University are mapping the tissues within ...
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  Mentions: Stanford University Texas A&M University Brian E. Applegate
16. Observing cochlear function
  
  Explore Home: SPIE.org Jun 23 2014 Otolaryngology
  
  Phase-sensitive optical coherence tomography measures the morphology and functional vibratory response in the mouse cochlea and helps decipher the complex mechanical processes responsible for hearing. Hearing loss is the most common sensory health issue due to the multiple effects of noise, aging, disease, and heredity. According to the World Health Organization, more than 360 million people worldwide suffer from disabling hearing loss. 1 Current therapies for hearing loss treat some of the symptoms by providing volume amplification, but there are no curative therapies. The development of effective therapies significantly depends upon a detailed understanding of the complex mechanisms of the ...
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  Mentions: Texas A&M University World Health Organization Brian E. Applegate
17. UC Irvine Receives at 2014 NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT
  
  Explore Optical Coherence Tomography News Jun 21 2014 Otolaryngology , Funding
  
  University of California Irvine Receives at 2014 NIH Grant for $122,254 for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT. The principal investigator is Jun Zhang. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States. Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for ...
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  Mentions: National Institutes of Health Zhongping Chen UC Irvine
18. Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe
  
  Explore SPIE | Journal May 10 2014 Otolaryngology
  
  Cochlear implantation offers the potential to restore sensitive hearing in patients with severe to profound deafness. However, surgical placement of the electrode array within the cochlea can produce trauma to sensorineural components, particularly if the initial turn of the cochlea is not successfully navigated as the array is advanced. In this work, we present a robot-mounted common-path swept-source optical coherence tomography endoscopic platform for three-dimensional (3-D) optical coherence tomography (OCT) registration and preoperative surgical planning for cochlear implant surgery. The platform is composed of a common-path 600- μ m diameter fiber optic rotary probe attached to a five degrees of freedom ...
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  Mentions: Johns Hopkins University University of Southern California Jin U. Kang
19. Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.
  
  Explore Optical Coherence Tomography News May 6 2014 Otolaryngology , Funding
  
  Oregon Health & Science University Receives a 2014 NIH Grant for $427,225 for Ossicle Vibration Measurements in Conductive Hearing Loss. The principle investigator is Steven Jacques. The program began in 2013 and ends in 2017. Below is a summary of hte propose work. The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane. The system is based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to ¿m amplitude. In Aim 1 ...
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  Mentions: National Institutes of Health Oregon Health & Science University Steven L. Jacques
20. Physical Sciences Receives NIH Grant for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear
  
  Explore Optical Coherence Tomography News Apr 10 2014 Otolaryngology , Funding
  
  Physical Sciences Received at 2014 NIH Grant for $197,522 for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear. The principal investigator is Ernest Chang. The program begins and ends in 2014. Below is a summary of the proposed work. There is a growing clinical need for improving the non-invasive diagnostic capabilities of middle ear pathologies in vivo. To address this need, Physical Sciences Inc. (PSI), in collaboration with the Eaton Peabody Lab at the Massachusetts Eye and Ear Infirmary (MEEI), will develop a clinically viable otoscopic imaging system that will employ phase sensitive optical coherence tomography (OCT) to ...
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  Mentions: National Institutes of Health Physical Sciences Incorporated Massachusetts Eye and Ear Infirmary
21. In vivo imaging of middle-ear and inner-ear microstructures of a mouse guided by SD-OCT combined with a surgical microscope
  
  Explore opticsinfobase.org Apr 7 2014 Microscopy , Otolaryngology
  
  We developed an augmented-reality system that combines optical coherence tomography (OCT) with a surgical microscope. By sharing the common optical path in the microscope and OCT, we could simultaneously acquire OCT and microscope views. The system was tested to identify the middle-ear and inner-ear microstructures of a mouse. Considering the probability of clinical application including otorhinolaryngology, diseases such as middle-ear effusion were visualized using in vivo mouse and OCT images simultaneously acquired through the eyepiece of the surgical microscope during surgical manipulation using the proposed system. This system is expected to realize a new practical area of OCT application.
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  Mentions: Jeehyun Kim Kyungpook National University
22. In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography
  
  Explore LWW Online Jan 31 2014 Otolaryngology
  
  Hypothesis Cochlear pathology can be evaluated in living animals using optical coherence tomography (OCT). Background The current imaging methods available for the detailed analysis of cochlear pathology in a clinical setting provide only limited information. Thus, a cochlear imaging modality with high definition is needed for improving the diagnosis of cochlear pathology. OCT has been used in other fields for obtaining high-resolution subsurface images, and its use could potentially be extended to the analysis of cochlear pathogenesis. Methods Slc26a4 (–/–) mice, which generate endolymphatic hydrops, and their littermates were used in this study. Auditory function was monitored by the auditory brainstem ...
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23. Imaging of noncarious cervical lesions by means of a fast swept source optical coherence tomography system
  
  Explore Conference Proceedings Jan 15 2014 Dentistry , Oncology , Otolaryngology
  
  Non-carious cervical lesions (NCCL) are defined as the loss of tooth substance at the cemento-enamel junction and are caused by abrasion, erosion and/or occlusal overload. In this paper we proved that our fast swept source OCT system is a valuable tool to track the evolution of NCCL lesions in time. On several extracted bicuspids, four levels of NCCL were artificially created. After every level of induced lesion, OCT scanning was performed. B scans were acquired and 3D reconstructions were generated. The swept source OCT instrument used in this study has a central wavelength of 1050 nm, a sweeping range ...
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  Mentions: Adrian G. Podoleanu University of Kent Cosmin Sinescu
24. Imaging of oral pathological tissue using optical coherence tomography
  
  Explore Conference Proceedings Jan 15 2014 Oncology , Otolaryngology
  
  Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images ...
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  Mentions: Adrian G. Podoleanu University of Kent Cosmin Sinescu
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