Otolaryngology -Optical Coherence Tomography News

Articles in category: Otolaryngology

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1. Optical coherence tomography device for otitis media
  
  Explore uspto.gov Feb 25 2020 Otolaryngology , Patents
  
  An OCT apparatus and method for characterization of a fluid adjacent to a tympanic membrane has a low coherence source which is coupled to a splitter which has a measurement path and a reference path. The reference path is temporally modulated for length, and the combined signals from the reference path and the measurement path are applied to a detector. The detector examines the width of the response and the time variation when an optional excitation source is applied to the tympanic membrane, the width of the response and the time variation forming a metric indicating the viscosity of a ...
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2. PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards
  
  Explore Optical Coherence Tomography News Feb 7 2020 Otolaryngology , Other Business News
  
  PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced the company’s TOMi ™ Scope was awarded best healthcare product at the 12th Annual Prism Awards in San Francisco. The Prism Awards is an annual international competition that honors the best new optics and photonics products on the market. Since 2008, SPIE, along with media partner Photonics Media, has presented awards to companies and individuals that are creating products that make a difference, solve problems, and improve life through photonics. The Prism Awards reflect the exponential growth, exciting developments, and rich technical innovations ...
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  Mentions: Stephen A. Boppart FDA Ryan L. Shelton
3. Low-scattering volumes visualisation from optical coherence tomography data and its applications in otolaryngology
  
  Explore IOPscience Feb 2 2020 Otolaryngology
  
  The method for visualization of the low-scattering objects inside the bulk of the high-scattering tissue is presented. The method can contrast the low-scattering object of interest not only from the high scattering surroundings but from the noise region below the tissue image as well. The proposed method was applied for the visualization of the rodent and human cochlea volume.
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  Mentions: Institute of Applied Physics Grigory V. Gelikonov Valentin M. Gelikonov
4. Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope
  
  Explore SAGE Journals Jan 25 2020 Otolaryngology
  
  Objective To determine the feasibility of detecting and differentiating middle ear effusions (MEEs) using an optical coherence tomography (OCT) otoscope. Study Design Cross-sectional study. Setting US tertiary care children’s hospital. Subjects and Methods Seventy pediatric patients undergoing tympanostomy tube placement were preoperatively imaged using an OCT otoscope. A blinded reader quiz was conducted using 24 readers from 4 groups of tiered medical expertise. The primary outcome assessed was reader ability to detect presence/absence of MEE. A secondary outcome assessed was reader ability to differentiate serous vs nonserous MEE. Results OCT image data sets were analyzed from 45 of ...
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  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Ryan L. Shelton
5. USC Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes
  
  Explore Optical Coherence Tomography News Jan 21 2020 Otolaryngology , Funding
  
  University of Southern California Receives a 2020 NIH Grant for $672,471 for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin growth in the middle ear which facilitates erosion of ...
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  Mentions: National Institutes of Health University of Southern California Brian E. Applegate
6. Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty
  
  Explore SPIE Digital Library Jan 12 2020 Otolaryngology
  
  Objective measurement of the nasal valve region is valuable for the assessment of functional rhinoplasty surgical outcomes. Anatomical optical coherence tomography (aOCT) is an imaging modality that may be used to obtain real-time, quantitative, and volumetric scans of the nasal airway. We aim to evaluate if volumetric aOCT imaging is useful for the examination of the nasal valve region before and after functional rhinoplasty procedures. aOCT scans of the nasal valves were performed on four cadaveric heads before and after spreader graft and butterfly graft procedures. The resulting aOCT images were compared against video endoscopy images, and the segmented volumes ...
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  Mentions: Amy L. Oldenburg
7. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission
  
  Explore Optical Coherence Tomography News Jan 7 2020 Otolaryngology , Funding
  
  Massachusetts Eye and Ear Infirmary Receives a 2020 NIH Grant for $491,220 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...
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  Mentions: National Institutes of Health Massachusetts Eye and Ear Infirmary
8. University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma
  
  Explore Optical Coherence Tomography News Jan 7 2020 Otolaryngology , Funding
  
  University of Southern California Receives a 2020 NIH Grant for $710,479 for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...
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  Mentions: National Institutes of Health University of Southern California John S. Oghalai
9. PhotoniCare Announces FDA Clearance for First-In-Class Technology for Imaging the Ear
  
  Explore Optical Coherence Tomography News Jan 6 2020 Otolaryngology , Clinical Trials , Other Business News
  
  PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced that the U.S. Food & Drug Administration (FDA) has granted 510(k) clearance for its TOMi ™ Scope for non-invasive imaging of the middle ear. Using optical coherence tomography (OCT) high resolution depth imaging, TOMi Scope helps to determine the presence or absence of fluid in the middle ear and to characterize the fluid type. According to clinical guidelines, the presence of fluid in the middle ear is a primary indicator for determining infection. Designed to eliminate subjectivity and speculation, TOMi Scope allows physicians ...
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  Mentions: National Institutes of Health FDA Ryan L. Shelton
10. Sensing high frequency sub-nanometer vibrations using optical coherence tomography with real-time profilometry of multiple inner layers
  
  Explore ScienceDirect Dec 24 2019 Otolaryngology
  
  A robust technique for vibration sensing using Optical Coherence Tomography is introduced, which can yield nanometer- and sub-nanometer-scale vibration measurements for multiple inner layers simultaneously, even with low signal to noise ratio (SNR) signals from low cost devices. Constructing a camera-based parallel spectral domain optical coherence tomography device with just 40 dB SNR, we demonstrate as proof-of-principle, how our technique can work with vibration amplitudes over three orders of magnitude, from hundreds of picometers to hundreds of nanometers. Our technique is unrestricted by the Nyquist sampling limit. This makes it suitable for measuring amplitudes of even MHz frequency vibrations which ...
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11. PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition
  
  Explore Optical Coherence Tomography News Dec 7 2019 Otolaryngology , Other Business News
  
  PhotoniCare took home first place at the 7th Annual Insight Product Development 2019 HealthTECH Startup Competition. The annual competition, sponsored by Insight Innovation Center – Chicago, MATTER, and iBIO, brings together a mix of healthcare industry and community stakeholders. The program aims to achieve the following goals: Improve lives by bringing innovative health solutions to patients Encourage entrepreneurship in the healthcare industry Grow the medical innovation ecosystem Connect investors and corporations with early-stage companies The competition included 10 finalists, selected based on a competitive application process, which came together on November 14th in Chicago, Illinois, to each give a five-minute startup ...
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  Mentions: PhotoniCare
12. The PhotoniCare team caps off a successful 2019 with a move to a new location
  
  Explore PhotoniCare, Inc. Nov 21 2019 Otolaryngology , Other Business News
  
  2019 has been a very exciting AND BUSY year for the PhotoniCare team. In particular, the year has brought more growth and movement forward for the staff than ever before. Between funding agreements, opportunities for research studies, multiple industry trade shows, and more, the team has been busier than ever. If you’re just tuning in, here’s a snapshot of just a few of PhotoniCare’s 2019 highlights: Entered into an exclusive distribution agreement with Adachi Co., LTD , (Osaka, Japan) to commercialize the TOMi ™ Scope device throughout Japan. ( read more here ) Initiated a multi-site registered clinical study to evaluate ...
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  Mentions: Ryan L. Shelton PhotoniCare
13. The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa
  
  Explore Wiley Online Library Nov 18 2019 Otolaryngology
  
  Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and neck mucosa. Previous work has utilized 2‐D OCT imaging which is limited to the evaluation of a small regions of interest generated frame by frame. OCT technology is capable of ...
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  Mentions: Zhongping Chen UC Irvine William B. Armstrong
14. Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography
  
  Explore e-ceo.org Nov 5 2019 Otolaryngology
  
  Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging. Method. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images. Results. The middle ear microstructures such as ...
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  Mentions: Pusan National University
15. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography
  
  Explore LWW Online Oct 24 2019 Otolaryngology
  
  Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...
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  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney
16. High-resolution Imaging of the Human Cochlea through the Round Window by means of Optical Coherence Tomography
  
  Explore Nature Publishing Group Oct 9 2019 Otolaryngology
  
  The human cochlea is deeply embedded in the temporal bone and surrounded by a thick otic capsule, rendering its internal structure inaccessible for direct visualization. Clinical imaging techniques fall short of their resolution for imaging of the intracochlear structures with sufficient detail. As a result, there is a lack of knowledge concerning best practice for intracochlear therapy placement, such as cochlear implantation. In the past decades, optical coherence tomography (OCT) has proven valuable for non-invasive, high-resolution, cross-sectional imaging of tissue microstructure in various fields of medicine, including ophthalmology, cardiology and dermatology. There is an upcoming interest for OCT imaging of ...
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17. The frequency limit of outer hair cell motility measured in vivo
  
  Explore Latest research Sep 24 2019 Otolaryngology
  
  Outer hair cells (OHCs) in the mammalian ear exhibit electromotility, electrically driven somatic length changes that are thought to mechanically amplify sound-evoked vibrations. For this amplification to work, OHCs must respond to sounds on a cycle-by-cycle basis even at frequencies that exceed the low-pass corner frequency of their cell membranes. Using in vivo optical vibrometry we tested this theory by measuring sound-evoked motility in the 13–25 kHz region of the gerbil cochlea. OHC vibrations were strongly rectified, and motility exhibited first-order low-pass characteristics with corner frequencies around 3 kHz– more than 2.5 octaves below the frequencies the OHCs ...
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18. Compensation for the Influence of Fluctuations in the Distance to the Object During Noncontact Probing in Spectral Domain Optical Coherence Tomography
  
  Explore Home - Springer Sep 14 2019 Otolaryngology
  
  We propose and experimentally test a numerical method for correction of the influence of fluctuations in the distance to objects during noncontact probing in optical coherence tomography. The method is based on the analysis of phase shifts of the neighboring scans, which are due to microscale displacements, and further compensation for these displacements by using phasefrequency correction in the spectral domain. Unlike the known correlation methods, the proposed method does not distort the represented shape of the object surface. Its operability is demonstrated in model experiments in the cases of harmonic and random types of the motion of the scattering ...
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  Mentions: Institute of Applied Physics Grigory V. Gelikonov Valentin M. Gelikonov
19. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review
  
  Explore OMICS Group Sep 14 2019 Otolaryngology , Pulmonology
  
  Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface as well as the complex 3D anatomical shape. Previous studies indicate that changes in airway histopathology can be found in the OCT image almost immediately after inhalation of smoke and ...
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  Mentions: Zhongping Chen UC Irvine Matthew Brenner
20. Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography
  
  Explore MDPI Open Access Journals Platform Sep 10 2019 Otolaryngology
  
  Optical coherence tomography (OCT) has a micro-resolution with a penetration depth of about 2 mm and field of view of about 10 mm. This makes OCT well suited for analyzing the anatomical and internal structural assessment of the middle ear. To study the vibratory motion of the tympanic membrane (TM) and its internal structure, we developed a phase-resolved Doppler OCT system using Kasai’s autocorrelation algorithm. Doppler optical coherence tomography is a powerful imaging tool which can offer the micro-vibratory measurement of the tympanic membrane and obtain the micrometer-resolved cross-sectional images of the sample in real-time. To observe the relative ...
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  Mentions: Jeehyun Kim Kyungpook National University Mansik Jeon
21. Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis
  
  Explore SPIE Digital Library Sep 10 2019 Otolaryngology
  
  Subglottic stenosis (SGS) is a challenging disease to diagnose in neonates. Long-range optical coherence tomography (OCT) is an optical imaging modality that has been described to image the subglottis in intubated neonates. A major challenge associated with OCT imaging is the lack of an automated method for image analysis and micrometry of large volumes of data that are acquired with each airway scan (1 to 2 Gb). We developed a tissue segmentation algorithm that identifies, measures, and conducts image analysis on tissue layers within the mucosa and submucosa and compared these automated tissue measurements with manual tracings. We noted small ...
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  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
22. Method and apparatus for obtaining a three-dimensional map of tympanic membrane thickness
  
  Explore uspto.gov Sep 3 2019 Otolaryngology , Patents
  
  Methods and apparatus for combining a low coherence interferometry (LCI) technique for single-point thickness measurement with videootoscopy for recording the image of a tissue such as the tympanic membrane (TM). TM thickness distribution maps are obtained by mapping the LCI imaging sites onto an anatomically accurate wide-field image of the TM, generated by mosaicking a sequence of multiple small field-of-view video-otoscopy images.
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  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Ryan L. Shelton
23. Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics
  
  Explore OSA | OSA Publishing Aug 10 2019 Otolaryngology
  
  Voice disorders affect a large number of adults in the United States, and their clinical evaluation heavily relies on laryngeal videostroboscopy, which captures the medial-lateral and anterior-posterior motion of the vocal folds using stroboscopic sampling. However, videostroboscopy does not provide direct visualization of the superior-inferior movement of the vocal folds, which yields important clinical insight. In this paper, we present a novel technology that complements videostroboscopic findings by adding the ability to image the coronal plane and visualize the superior-inferior movement of the vocal folds. The technology is based on optical coherence tomography, which is combined with videostroboscopy within the ...
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  Mentions: Massachusetts General Hospital Physical Sciences Incorporated Nicusor Iftimia
24. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system
  
  Explore Digital Object Identifier System Aug 6 2019 Otolaryngology
  
  We have developed a highly phase stable optical coherence tomography and vibrometry system that attaches directly to the accessory area of a surgical microscope common to both the otology clinic and operating room. Careful attention to minimizing sources of phase noise has enabled a system capable of measuring vibrations of the middle ear with a sensitivity of < 5 pm in an awake human patient. The system is shown to be capable of collecting a wide range of information on the morphology and function of the ear in live subjects, including frequency tuning curves below the hearing threshold, maps of tympanic ...
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  Mentions: Texas A&M University UCLA Brian E. Applegate
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