1. Articles in category: Otolaryngology

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    1. UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology

      UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology

      University of California at Irvine Receives a 2020 NIH Grant for $593,557 for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Each year, 50M Americans suffer from chronic rhinosinusitis (CRS) and allergic rhinitis (AR). The economic impact accounts for over $35B/year in health care expenditures alone, with over 3.5M work and 2M school days lost each year. Accordingly, over 600K operations per year are performed to treat sinonasal disease. The disease burden is immense with a profound ...

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    2. Evaluation of middle ear reconstruction by endoscopic Optical Coherence Tomography

      Evaluation of middle ear reconstruction by endoscopic Optical Coherence Tomography

      Introduction Endoscopic Optical Coherence Tomography (eOCT) allows high-resolution 3-dimensional imaging of the tympanic membrane and the adjacent areas of the middle ear. Doppler-OCT enables oscillation measurement. Thus, the postoperative outcome of tympanoplasty can be evaluated. Material and Methods 5 Patients were examined after tympanoplasty using eOCT. The system utilizes a near infrared laser with a central wavelength of 1300 nm and a working range of 8 mm. The thickness of the tympanic membrane and of the reconstruction were determined as well as the coupling of the prostheses. Furthermore, the oscillation of the reconstructed tympanic membrane and of the prostheses was ...

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    3. Device and system for doppler optical coherence tomography (OCT) of the human middle ear

      Device and system for doppler optical coherence tomography (OCT) of the human middle ear

      A device for Doppler optical coherence tomography (Doppler OCT), preferably of the human middle ear, is proposed. The device has an endoscope unit for at least partial insertion into the auditory canal. A sound source, a sound receiver, and OCT optics are integrated in the endoscope unit.

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    4. University of Wisconsin Receives NIH Grant for The Interactions Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin Receives NIH Grant for The Interactions Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin Receives a 2020 NIH Grant for $368,084 for The Interactions Between Vocal Fold Hydration and Vibratory Biomechanics. The principal investigator is Jack Jiang. Below is a summary of the proposed work. Voice disorders affect millions of people worldwide. Patients have reported many negative social economic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and inflammation. The results of these disturbances can lead to ...

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    5. Future Directions of Optical Coherence Tomography in Otology: A Morphological and Functional Approach

      Future Directions of Optical Coherence Tomography in Otology: A Morphological and Functional Approach

      Optical coherence tomography (OCT) is a real-time optical imaging modality that enables tomographic imaging at the submicron scale. Basic research into applications of OCT systems in the field of otology has been conducted. For instance, Oh et al. [1] recently reported that OCT provided noninvasive, nondestructive two-dimensional cross-sectional and three-dimensional volumetric images of middle-ear and inner ear structures in rodents. Anatomical depth-resolved imaging has shown promising potential for morphological measurements of the middle and inner ear in chinchillas [2] and mice with blast trauma [3]. Moreover, OCT has demonstrated its capability as a functional analytical tool by characterizing the vibration ...

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    6. Massachusetts Eye and Ear Infirmary Receives NIH Grant for Human Cochlear Structure & Function

      Massachusetts Eye and Ear Infirmary Receives NIH Grant for Human Cochlear Structure & Function

      Massachusetts Eye and Ear Infirmary Receives a 2020 NIH Grant for $544,982 for Human Cochlear Structure & Function. The principal investigator is Hideko Nakajima . Below is a summary of the proposed work. Although the inner workings of the cochlea are responsible for the most fundamental aspects of hearing, including hearing sensitivity and frequency tuning, our direct knowledge of human cochlear mechanics is limited. This lack of information has forced researchers to rely on animal experiments to make inferences about cochlear behavior in humans, under the assumption that the motions of the cochlear partition (CP), including the basilar membrane (BM) and ...

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    7. Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplification

      Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplification

      Columbia University Receives a 2020 NIH Grant for $428,832 for Auditory Mechanics and Cochlear Amplification. The principal investigator is Elizabeth Olson. Below is a summary of the proposed work. Sound input to the inner ear (cochlea) causes a frequency-segregated wave-pattern of sensory tissue motion that conveys sound information to the auditory neurons, leading to hearing. A currently untreatable aspect of hearing impairment is the deterioration of the cochlea's ability to sharply segregate sound by frequency. The cochlea's healthy frequency tuning is largely provided by the cochlear amplifier, an outer-hair-cell-driven, place-frequency-localized electromechanical engine that is both powerful and ...

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    8. Optical coherence tomography device for otitis media

      Optical coherence tomography device for otitis media

      An OCT apparatus and method for characterization of a fluid adjacent to a tympanic membrane has a low coherence source which is coupled to a splitter which has a measurement path and a reference path. The reference path is temporally modulated for length, and the combined signals from the reference path and the measurement path are applied to a detector. The detector examines the width of the response and the time variation when an optional excitation source is applied to the tympanic membrane, the width of the response and the time variation forming a metric indicating the viscosity of a ...

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    9. PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced the company’s TOMi ™ Scope was awarded best healthcare product at the 12th Annual Prism Awards in San Francisco. The Prism Awards is an annual international competition that honors the best new optics and photonics products on the market. Since 2008, SPIE, along with media partner Photonics Media, has presented awards to companies and individuals that are creating products that make a difference, solve problems, and improve life through photonics. The Prism Awards reflect the exponential growth, exciting developments, and rich technical innovations ...

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    10. Low-scattering volumes visualisation from optical coherence tomography data and its applications in otolaryngology

      Low-scattering volumes visualisation from optical coherence tomography data and its applications in otolaryngology

      The method for visualization of the low-scattering objects inside the bulk of the high-scattering tissue is presented. The method can contrast the low-scattering object of interest not only from the high scattering surroundings but from the noise region below the tissue image as well. The proposed method was applied for the visualization of the rodent and human cochlea volume.

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    11. Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope

      Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope

      Objective To determine the feasibility of detecting and differentiating middle ear effusions (MEEs) using an optical coherence tomography (OCT) otoscope. Study Design Cross-sectional study. Setting US tertiary care children’s hospital. Subjects and Methods Seventy pediatric patients undergoing tympanostomy tube placement were preoperatively imaged using an OCT otoscope. A blinded reader quiz was conducted using 24 readers from 4 groups of tiered medical expertise. The primary outcome assessed was reader ability to detect presence/absence of MEE. A secondary outcome assessed was reader ability to differentiate serous vs nonserous MEE. Results OCT image data sets were analyzed from 45 of ...

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    12. USC Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      USC Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives a 2020 NIH Grant for $672,471 for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin growth in the middle ear which facilitates erosion of ...

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    13. Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty

      Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty

      Objective measurement of the nasal valve region is valuable for the assessment of functional rhinoplasty surgical outcomes. Anatomical optical coherence tomography (aOCT) is an imaging modality that may be used to obtain real-time, quantitative, and volumetric scans of the nasal airway. We aim to evaluate if volumetric aOCT imaging is useful for the examination of the nasal valve region before and after functional rhinoplasty procedures. aOCT scans of the nasal valves were performed on four cadaveric heads before and after spreader graft and butterfly graft procedures. The resulting aOCT images were compared against video endoscopy images, and the segmented volumes ...

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      Mentions: Amy L. Oldenburg
    14. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      Massachusetts Eye and Ear Infirmary Receives a 2020 NIH Grant for $491,220 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

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    15. University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a 2020 NIH Grant for $710,479 for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    16. PhotoniCare Announces FDA Clearance for First-In-Class Technology for Imaging the Ear

      PhotoniCare Announces FDA Clearance for First-In-Class Technology for Imaging the Ear

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced that the U.S. Food & Drug Administration (FDA) has granted 510(k) clearance for its TOMi ™ Scope for non-invasive imaging of the middle ear. Using optical coherence tomography (OCT) high resolution depth imaging, TOMi Scope helps to determine the presence or absence of fluid in the middle ear and to characterize the fluid type. According to clinical guidelines, the presence of fluid in the middle ear is a primary indicator for determining infection. Designed to eliminate subjectivity and speculation, TOMi Scope allows physicians ...

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    17. Sensing high frequency sub-nanometer vibrations using optical coherence tomography with real-time profilometry of multiple inner layers

      Sensing high frequency sub-nanometer vibrations using optical coherence tomography with real-time profilometry of multiple inner layers

      A robust technique for vibration sensing using Optical Coherence Tomography is introduced, which can yield nanometer- and sub-nanometer-scale vibration measurements for multiple inner layers simultaneously, even with low signal to noise ratio (SNR) signals from low cost devices. Constructing a camera-based parallel spectral domain optical coherence tomography device with just 40 dB SNR, we demonstrate as proof-of-principle, how our technique can work with vibration amplitudes over three orders of magnitude, from hundreds of picometers to hundreds of nanometers. Our technique is unrestricted by the Nyquist sampling limit. This makes it suitable for measuring amplitudes of even MHz frequency vibrations which ...

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    18. PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition

      PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition

      PhotoniCare took home first place at the 7th Annual Insight Product Development 2019 HealthTECH Startup Competition. The annual competition, sponsored by Insight Innovation Center – Chicago, MATTER, and iBIO, brings together a mix of healthcare industry and community stakeholders. The program aims to achieve the following goals: Improve lives by bringing innovative health solutions to patients Encourage entrepreneurship in the healthcare industry Grow the medical innovation ecosystem Connect investors and corporations with early-stage companies The competition included 10 finalists, selected based on a competitive application process, which came together on November 14th in Chicago, Illinois, to each give a five-minute startup ...

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      Mentions: PhotoniCare
    19. The PhotoniCare team caps off a successful 2019 with a move to a new location

      The PhotoniCare team caps off a successful 2019 with a move to a new location

      2019 has been a very exciting AND BUSY year for the PhotoniCare team. In particular, the year has brought more growth and movement forward for the staff than ever before. Between funding agreements, opportunities for research studies, multiple industry trade shows, and more, the team has been busier than ever. If you’re just tuning in, here’s a snapshot of just a few of PhotoniCare’s 2019 highlights: Entered into an exclusive distribution agreement with Adachi Co., LTD , (Osaka, Japan) to commercialize the TOMi ™ Scope device throughout Japan. ( read more here ) Initiated a multi-site registered clinical study to evaluate ...

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    20. The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and neck mucosa. Previous work has utilized 2‐D OCT imaging which is limited to the evaluation of a small regions of interest generated frame by frame. OCT technology is capable of ...

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    21. Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

      Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

      Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging. Method. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images. Results. The middle ear microstructures such as ...

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    22. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...

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    23. High-resolution Imaging of the Human Cochlea through the Round Window by means of Optical Coherence Tomography

      High-resolution Imaging of the Human Cochlea through the Round Window by means of Optical Coherence Tomography

      The human cochlea is deeply embedded in the temporal bone and surrounded by a thick otic capsule, rendering its internal structure inaccessible for direct visualization. Clinical imaging techniques fall short of their resolution for imaging of the intracochlear structures with sufficient detail. As a result, there is a lack of knowledge concerning best practice for intracochlear therapy placement, such as cochlear implantation. In the past decades, optical coherence tomography (OCT) has proven valuable for non-invasive, high-resolution, cross-sectional imaging of tissue microstructure in various fields of medicine, including ophthalmology, cardiology and dermatology. There is an upcoming interest for OCT imaging of ...

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