1. Articles in category: Otolaryngology

    1-24 of 192 1 2 3 4 5 6 7 8 »
    1. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear

      Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear

      Phase-sensitive optical coherence tomography (PhOCT) offers exquisite sensitivity to mechanical vibration in biological tissues. There is growing interest in using PhOCT for imaging the nanometer scale vibrations of the ear in animal models of hearing disorders. Swept-source-based systems offer fast acquisition speeds, suppression of common mode noise via balanced detection, and good signal roll-off. However, achieving high phase stability is difficult due to nonlinear laser sweeps and trigger jitter in a typical swept laser source. Here, we report on the initial application of a Vernier-tuned distributed Bragg reflector (VT-DBR) swept laser as the source for a fiber-based PhOCT system. The ...

      Read Full Article
    2. Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale

      Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale

      Lasers have been proven to be precise tools for bone ablation. Applying no mechanical stress to the patient, they are potentially very suitable for microsurgery on fragile structures such as the inner ear. However, it remains challenging to control the laser-bone ablation without injuring embedded soft tissue. In this work, we demonstrate a closed-loop control of a short-pulsed CO 2 laser to perform laser cochleostomy under the monitoring of an optical coherence tomography (OCT) system. A foresighted detection of the bone-endosteum-perilymph boundary several hundred micrometers before its exposure has been realized. Position and duration of the laser pulses are planned ...

      Read Full Article
    3. The role of physics in inner-ear physiology and auditory perception

      The role of physics in inner-ear physiology and auditory perception

      Auditory analysis of acoustical stimuli has mainly been connected with Fourier analysis. This touches the basic link between auditory perception and the operation of the hearing organs, namely, physics and mathematics. This relation has amply been demonstrated by the work and ideas of Georg von Békésy. Later, the healthy cochlea (inner ear) was found to contain amplifying elements that boost frequency selectivity. Associated with this there is a pronounced nonlinearity. Furthermore, the ear does not only absorb and process sounds, it also emits sound waves. Mathematical models of all these processes must contain subsets serving them all, a ...

      Read Full Article
    4. Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography

      Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography

      Objectives: (1) Show the possibility of using optical coherence tomography (OCT) to visualize the internal structure of the vestibule and semicircular canals with the bony capsule intact. (2) Study the effect of the decalcification. OCT is a nondestructive imaging modality that uses infrared light as it penetrates turbid biological tissue. Previously, OCT has been successfully used to visualize inside the cochlea in normal and abnormal inner ears. Methods: The OCT system, OCS-1300SS (Thorlabs, Inc, NJ) with a central wavelength of 1300 nm and a theoretical axial resolution of 9 µm, was employed for image acquisition. Normal and Slc26a4 mutant mice ...

      Read Full Article
    5. First Use of Long-Range Optical Coherence Tomography to Image Airway Structure in Awake Children

      First Use of Long-Range Optical Coherence Tomography to Image Airway Structure in Awake Children

      Objectives: Identifying the appropriate operation(s) for children with sleep-disordered breathing (SDB) remains a challenge, and current imaging modalities have major shortcomings. We have pioneered the use of long-range optical coherence tomography (LR-OCT) to provide real-time images of the upper airway (UA) during sleep and wakefulness. Here we present our first use of LR-OCT to image the UA of awake children. (1) Understand how LR-OCT produces high-resolution structural images by acting as an optical range-finder. (2) Recognize how LR-OCT can identify strictures and real-time collapse of the airway. Methods: This study builds upon our experience using LR-OCT to image 58 ...

      Read Full Article
    6. Experimental and Modeling Study of Human Tympanic Membrane Motion in the Presence of Middle Ear Liquid

      Experimental and Modeling Study of Human Tympanic Membrane Motion in the Presence of Middle Ear Liquid

      Vibration of the tympanic membrane (TM) has been measured at the umbo using laser Doppler vibrometry and analyzed with finite element (FE) models of the human ear. Recently, full-field TM surface motion has been reported using scanning laser Doppler vibrometry, holographic interferometry, and optical coherence tomography. Technologies for imaging human TM motion have the potential to lead to using a dedicated clinical diagnosis tool for identification of middle ear diseases. However, the effect of middle ear fluid (liquid) on TM surface motion is still not clear. In this study, a scanning laser Doppler vibrometer was used to measure the full-field ...

      Read Full Article
    7. Do You Hear That? It Sounds Like a Technology Breakthrough

      Do You Hear That? It Sounds Like a Technology Breakthrough

      The inner workings of the ear have been a mystery for decades. However, that’s all about to change thanks to the efforts of a team of researchers determined to shed some light on the hearing process. Researchers from Stanford University and Texas A&M are working on mapping the tissues of the cochlea, the portion of the inner ear responsible for hearing. To map the cochlea, they used a technique known as optical coherence tomography (OCT) on animal models. OCT is similar to ultrasound but generates very high-resolution images, along with terabytes of measurement data. This data must be ...

      Read Full Article
    8. High-resolution images of inner ear could lead to new hearing loss therapies

      High-resolution images of inner ear could lead to new hearing loss therapies

      Understanding how hearing works has long been hampered by challenges associated with seeing inside the inner ear, but technology being developed by a team of researchers that includes a biomedical engineer from Texas A&M University is generating some of the most detailed images of the inner ear to date while offering new insight into the mechanics of hearing that could lead to new therapies for hearing loss. Employing a technique that generates high-resolution, three-dimensional images, Brian Applegate, associate professor in the Department of Biomedical Engineering at Texas A&M, and colleagues from Stanford University are mapping the tissues within ...

      Read Full Article
    9. Observing cochlear function

      Observing cochlear function

      Phase-sensitive optical coherence tomography measures the morphology and functional vibratory response in the mouse cochlea and helps decipher the complex mechanical processes responsible for hearing.  Hearing loss is the most common sensory health issue due to the multiple effects of noise, aging, disease, and heredity. According to the World Health Organization, more than 360 million people worldwide suffer from disabling hearing loss. 1 Current therapies for hearing loss treat some of the symptoms by providing volume amplification, but there are no curative therapies. The development of effective therapies significantly depends upon a detailed understanding of the complex mechanisms of the ...

      Read Full Article
    10. UC Irvine Receives at 2014 NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      UC Irvine Receives at 2014 NIH Grant  for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      University of California Irvine Receives at 2014 NIH Grant for $122,254 for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT. The principal investigator is Jun Zhang. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States. Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for ...

      Read Full Article
    11. Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe

      Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe

      Cochlear implantation offers the potential to restore sensitive hearing in patients with severe to profound deafness. However, surgical placement of the electrode array within the cochlea can produce trauma to sensorineural components, particularly if the initial turn of the cochlea is not successfully navigated as the array is advanced. In this work, we present a robot-mounted common-path swept-source optical coherence tomography endoscopic platform for three-dimensional (3-D) optical coherence tomography (OCT) registration and preoperative surgical planning for cochlear implant surgery. The platform is composed of a common-path 600- μ m diameter fiber optic rotary probe attached to a five degrees of freedom ...

      Read Full Article
    12. Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.

      Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.

      Oregon Health & Science University Receives a 2014 NIH Grant for $427,225 for Ossicle Vibration Measurements in Conductive Hearing Loss. The principle investigator is Steven Jacques. The program began in 2013 and ends in 2017. Below is a summary of hte propose work. The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane. The system is based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to ¿m amplitude. In Aim 1 ...

      Read Full Article
    13. Physical Sciences Receives NIH Grant for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear

      Physical Sciences Receives NIH Grant for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear

      Physical Sciences Received at 2014 NIH Grant for $197,522 for A Functional Otoscopy for Non-Invasive Diagnosis of Middle Ear. The principal investigator is Ernest Chang. The program begins and ends in 2014. Below is a summary of the proposed work. There is a growing clinical need for improving the non-invasive diagnostic capabilities of middle ear pathologies in vivo. To address this need, Physical Sciences Inc. (PSI), in collaboration with the Eaton Peabody Lab at the Massachusetts Eye and Ear Infirmary (MEEI), will develop a clinically viable otoscopic imaging system that will employ phase sensitive optical coherence tomography (OCT) to ...

      Read Full Article
    14. In vivo imaging of middle-ear and inner-ear microstructures of a mouse guided by SD-OCT combined with a surgical microscope

      In vivo imaging of middle-ear and inner-ear microstructures of a mouse guided by SD-OCT combined with a surgical microscope

      We developed an augmented-reality system that combines optical coherence tomography (OCT) with a surgical microscope. By sharing the common optical path in the microscope and OCT, we could simultaneously acquire OCT and microscope views. The system was tested to identify the middle-ear and inner-ear microstructures of a mouse. Considering the probability of clinical application including otorhinolaryngology, diseases such as middle-ear effusion were visualized using in vivo mouse and OCT images simultaneously acquired through the eyepiece of the surgical microscope during surgical manipulation using the proposed system. This system is expected to realize a new practical area of OCT application.

      Read Full Article
    15. In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography

      In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography

      Hypothesis Cochlear pathology can be evaluated in living animals using optical coherence tomography (OCT). Background The current imaging methods available for the detailed analysis of cochlear pathology in a clinical setting provide only limited information. Thus, a cochlear imaging modality with high definition is needed for improving the diagnosis of cochlear pathology. OCT has been used in other fields for obtaining high-resolution subsurface images, and its use could potentially be extended to the analysis of cochlear pathogenesis. Methods Slc26a4 (–/–) mice, which generate endolymphatic hydrops, and their littermates were used in this study. Auditory function was monitored by the auditory brainstem ...

      Read Full Article
    16. Imaging of noncarious cervical lesions by means of a fast swept source optical coherence tomography system

      Imaging of noncarious cervical lesions by means of a fast swept source optical coherence tomography system

      Non-carious cervical lesions (NCCL) are defined as the loss of tooth substance at the cemento-enamel junction and are caused by abrasion, erosion and/or occlusal overload. In this paper we proved that our fast swept source OCT system is a valuable tool to track the evolution of NCCL lesions in time. On several extracted bicuspids, four levels of NCCL were artificially created. After every level of induced lesion, OCT scanning was performed. B scans were acquired and 3D reconstructions were generated. The swept source OCT instrument used in this study has a central wavelength of 1050 nm, a sweeping range ...

      Read Full Article
    17. Imaging of oral pathological tissue using optical coherence tomography

      Imaging of oral pathological tissue using optical coherence tomography

      Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images ...

      Read Full Article
    18. Physical Sciences Incorporated Receives 2014 NIH Grant for Integrating Optical Coherence Tomography with Laryngeal High-Speed Videoendoscopy

      Physical Sciences Incorporated Receives 2014 NIH Grant for Integrating Optical Coherence Tomography with Laryngeal High-Speed Videoendoscopy

      Physical Sciences Incorporated Received a 2014 NIH Grant for $224,955 for Integrating Optical Coherence Tomography with Laryngeal High-Speed Videoendoscopy. The principal investigator is Ernest Chang. The program began in 2014 and ends in 2014. Below is a summary of the proposed work. There is a growing clinical need for improving the assessment of vocal fold tissue properties in vivo, especially dynamic properties measured during human voice production. To address this need, Physical Sciences Inc. (PSI), in collaboration with MGH Voice Center, will develop a clinically-viable imaging system that will integrate optical coherence tomography (OCT) with laryngeal high-speed videoendoscopy (HSV ...

      Read Full Article
    19. Optical Coherence Tomography for Oral Mucosal Lesions – A Review Article

      Optical Coherence Tomography for Oral Mucosal Lesions – A Review Article

      Optical coherence tomography (OCT) is used to produce the cross sectional images of tissues. It is a non-invasive technique. It was first introduced by Huang and co-workers in 1991. It can be used for imaging and diagnosing epithelial and subepithelial dysplastic changes within the oral mucosal tissues and in the detection of early oral cancer. Optical coherence tomography produces higher resolution for imaging the epithelium and lamina propria within the normal and dysplastic oral mucosal tissues. Optical coherence tomography technique utilizes near infrared light which allows it to penetrate into the scattering medium and produces submicrometer resolution. OCT can also ...

      Read Full Article
    20. Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry

      Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry

      In this work we determined the contributions of loud sound exposure (LSE) on cochlear blood flow (CoBF) in an in vivo anesthetized mouse model. A broadband noise system (20 kHz bandwidth) with an intensity of 119 dB SPL, was used for a period of one hour to produce a loud sound stimulus. Two techniques were used to study the changes in blood flow, a Doppler optical microangiography (DOMAG) system; which can measure the blood flow within individual cochlear vessels, and a laser Doppler flowmetry (LDF) system; which averages the blood flow within a volume (a hemisphere of ~1.5 mm ...

      Read Full Article
    21. Optical Imaging of Oral Squamous Cell Carcinoma Using Optical Coherence Tomography and Micro CT

      Optical Imaging of Oral Squamous Cell Carcinoma Using Optical Coherence Tomography and Micro CT

      Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival and to reduce diagnostic delay. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method. OCT represents a new high-resolution optical technique that permits 3D, real-time imaging of near surface abnormalities in complex tissues. In the present study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT and Micro-CT investigation. For the OCT imaging it was used an OCT prototype (1300 nm), Synchrotron Radiation Micro-CT and histopathology validated the results. Areas of ...

      Read Full Article
    22. Endoscopic Anatomy of the Pediatric Middle Ear

      Endoscopic Anatomy of the Pediatric Middle Ear

      Traditionally, otologists have aimed to produce a clean, dry, safe ear with the best possible hearing result. More recently, “less invasively” has been added to this list of goals. The development of small-diameter, high-quality rigid endoscopes and high-definition video systems has made totally endoscopic, transcanal surgery a reality in adult otology and a possibility in pediatric otology. This article reviews the anatomy of the pediatric middle ear and its surrounding airspaces and structures based on the work of dozens of researchers over the past 50 years. It will focus on the developmental changes in ear anatomy from birth through the ...

      Read Full Article
    23. Evaluation of the Internal Structure of Normal and Pathological Guinea Pig Cochleae Using Optical Coherence Tomography

      Evaluation of the Internal Structure of Normal and Pathological Guinea Pig Cochleae Using Optical Coherence Tomography

      Optical coherence tomography (OCT) makes it possible to visualize the internal structures of several organs, such as the eye, in vivo. Although visualization of the internal structures of the inner ear has been used to try and identify certain pathological conditions, attempts have failed mainly due to the thick bony capsule surrounding this end organ. After decalcifying the bony wall of the cochlea with ethylenediamine tetraacetic acid, we could clearly visualize its internal structures by using OCT. We identified endolymphatic hydrops, strial atrophy and damage to the organ of Corti, evident as a distention of Reissner's membrane, thinning of ...

      Read Full Article
    24. New Concepts in Vocal Fold Imaging: A Review

      New Concepts in Vocal Fold Imaging: A Review

      Objective To review new imaging technology potentially useful in the clinical practice of laryngology. Hypothesis Narrow band imaging, iScan (Pentax Medical Company, Montvale, NJ), optical computed tomography, and confocal microscopy have potential value for enhancing diagnosis of laryngeal pathology. Design Literature review. Methods Literature search of computer databases including MEDLINE and PubMed. Results A review of 50 articles suggests that new imaging technologies may enhance clinical diagnostic capabilities. Conclusion The probable value of new imaging technologies suggests that further research is needed to refine these technologies and define their clinical efficacy.

      Read Full Article
      Mentions: Pentax
    1-24 of 192 1 2 3 4 5 6 7 8 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles