1. Articles in category: Otolaryngology

    1-24 of 326 1 2 3 4 ... 12 13 14 »
    1. UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT for In-vivo identification of Bacterial Otitis Media

      UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT  for In-vivo identification of Bacterial Otitis Media

      University of Illinois at Urbana Champaign Receives a 2019 NIH Grant for $648,154 for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-vivo identification of Bacterial Otitis Media. The principal investigator is Stephen Boppart. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Otitis media (middle ear infection) is a highly prevalent disease, especially in young children. It has been documented that more than 75% of children will have at least one episode of otitis media (OM) by age 3, and many children will have recurrent or chronic OM ...

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    2. Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)

      Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)

      Currently, research is being conducted on single tone sound transduction within the auditory portion of the inner ear, the cochlea [1]. The study of cochlear mechanics in large rodents has provided important insight into cochlear function [1]. Additionally, multi-tone stimuli can provide a new perspective in vibrometric analyses that could be used in audiometry as a measure of hearing loss for patients in terms of both magnitude and their unique frequency envelope. Therefore, the proposed study was aimed to test the recent implementation of multitone calibration into an existing python program, PyVib2, which was used during Optical Coherence Tomography (OCT ...

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    3. PhotoniCare Looks Behind Ear Drums to Help Diagnose Ear Infections

      PhotoniCare Looks Behind Ear Drums to Help Diagnose Ear Infections

      Middle ear infections are one of the most common reasons for visits to the pediatrician. However, because the middle ear is hidden from view by the ear drum, physicians must diagnose based on symptoms and a limited physical exam — and when patients have ambiguous or borderline symptoms, accurate diagnosis can be challenging. PhotoniCare’s TOMi Scope uses near-infrared light waves to provide 3D views beyond the ear drum into the middle ear, allowing physicians to visualize and better diagnose middle ear infections. Co-founder and CEO Ryan Shelton, Ph.D. answered a few of our questions about his company’s beginnings ...

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    4. In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope

      In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope

      This study combined a previously developed optical system with two additional key elements: a supercontinuum light source characterized by high output power and an analytical technique that effectively extracts interference signals required for improving the detection limit of vibration amplitude. Our system visualized 3D tomographic images and nanometer scale vibrations in the cochlear sensory epithelium of a live guinea pig. The transverse- and axial-depth resolution was 3.6 and 2.7 µm, respectively. After exposure to acoustic stimuli of 21–25 kHz at a sound pressure level of 70–85 dB, spatial amplitude and phase distributions were quantified on a ...

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    5. Cracking the cochlea: U-M team creates mathematical model of ear’s speech center

      Cracking the cochlea: U-M team creates mathematical model of ear’s speech center

      New research paves the way for modeling the transduction of speech and music at the cochlear level. Until now, the part of the ear that processes speech was poorly reflected in computer models, but University of Michigan researchers have figured out the math that describes how it works. It could help improve hearing tests and devices that restore some hearing to the deaf. Inside the ear, a snail-shaped organ called the cochlea takes in pressure information from the eardrum and turns it into nerve impulses that are sent to the brain. A full understanding of how this tube-like structure does ...

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    6. Fiber-optic probe and bulk-optics Spectral Domain Optical Coherence tomography systems for in vivo cochlear mechanics measurements (Thesis)

      Fiber-optic probe and bulk-optics Spectral Domain Optical Coherence tomography systems for in vivo cochlear mechanics measurements (Thesis)

      Acquiring the motions of the inner ear sensory tissues provides insight to how the cochlea works. For this purpose, Spectral Domain Optical Coherence Tomography (SDOCT) is an ideal tool as it has a penetration depth of several millimeters. SDOCT can not only image inside the cochlear partition, but also measure the sample structures’ simultaneous displacements. We customized a commercial Spectral Domain Optical Coherence Tomography system for such functions and detailed the software and hardware steps so this powerful system could be more accessible to auditory researchers. The cochlea is surrounded by bones and tissues, and damage to it would make ...

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    7. University of Wisconsin-Madison Receives NIH Grant for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin-Madison Receives  NIH Grant for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin-Madison Receives a 2019 NIH Grant for $400,600 for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics. The principal investigator is Jack Jiang. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Voice disorders affect millions of people worldwide. Patients have reported many negative social econmic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and ...

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    8. Dalhousie researchers using laser technology to diagnose hearing loss

      Dalhousie researchers using laser technology to diagnose hearing loss

      Researchers at Dalhousie University in Halifax are using existing laser technology in a novel way to diagnose middle ear problems that cause hearing loss, without the need for more invasive procedures. Optical Coherence Tomography allows researchers to create two- and three-dimensional animated images of the middle ear to see whether there's anything irregular that could affect a patient's hearing. "It's a few seconds of tone," Dalhousie researcher Dan MacDougall told CBC's Information Morning as he demonstrated the device in the lab. "It's exciting … All the structures [of the ear] should vibrate in a predictable way ...

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    9. Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography

      Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography

      Optical coherence tomography (OCT) has revolutionized physiological studies of the hearing organ, the vibration and morphology of which can now be measured without opening the surrounding bone. In this review, we provide an overview of OCT as used in the otological research, describing advances and different techniques in vibrometry, angiography, and structural imaging.

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    10. Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives a 2019 NIH Grant for $ 505,632 for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance. The principal investigator is Jesung Park. The program began in 2016 and ends in 2021. Below is a summary of the proposed work.

      Sensorineural hearing loss (SNHL) is a source of significant morbidity and in isolated cases is irreversible. Most cases of SNHL are associated with damage or loss of cochlear hair cells. The diagnosis of SNHL is based primarily on audiometric testing as the inner ear cannot be “biopsied” without causing profound hearing loss. Contemporary ...

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    11. Quality Assessment of Tympanoplasty by Means of Endoscopic Optical Coherence Tomography

      Quality Assessment of Tympanoplasty by Means of Endoscopic Optical Coherence Tomography

      Introduction: The endoscopic optical coherence tomography (eOCT) allows the direct, contactless representation and evaluation of the morphology and oscillation behaviour of the tympanic membrane and adjoining tympanic cavity content. After further development of the measuring technology, the eOCT will be able to be used in vivo for the assessment of tympanoplasty results. Materials and Methods: The eOCT was applied to 10 patients after a tympanoplasty with an intact ossicular chain and to 10 patients after a Type III tympanoplasty. The measurement data of the morphology – especially the thickness – and oscillation behaviour of the tympanic membrane and the prosthesis coupling to ...

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    12. Endoscopic Optical Coherence Tomography in Diagnostics of Otosclerosis

      Endoscopic Optical Coherence Tomography in Diagnostics of Otosclerosis

      Introduction: Endoscopic Optical Coherence Tomography (eOCT) enables both high-resolution contact-free 3D-imaging of the tympanic membrane and spatial and frequency-resolved oscillation measurement via Doppler-OCT. Thus it is possible to detect causes of conduction hearing loss. In case of otosclerosis, changes in oscillation amplitude at the umbo had been showed via Laser-Doppler-Vibrometry. Material and Methods: The eOCT system utilizes a swept source laser with a wave length around 1300nm. Field-of-view and working distance are 10 mm. Sound stimulus was a Chirp in the frequency range between 0.5 and 5 kHz at 95 dB. Morphological and functional measurements were done on 12 ...

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    13. Biomedical optical techniques for intracochlear cellular imaging (Thesis)

      Biomedical optical techniques for intracochlear cellular imaging (Thesis)

      Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Under this situation, using suitable imaging techniques would be extremely helpful in detecting disease and diagnosing pathologies of the inner ear. However, cochlear small size and encasement in bone provide challenging obstacles, preventing visualization of intracochlear microanatomy using standard clinical imaging modalities. In this thesis, we explore optical techniques to image inner ear cells and we report an ...

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    14. University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives a 2019 NIH Grant for $215,469 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex ...

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    15. PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc., a medical device company headquartered in Champaign, Illinois, announces successful initiation of a multi-site registered clinical study to evaluate the imaging capabilities and image analysis performance of the PhotoniCare TOMi Scope. Children’s National Health System (Washington, D.C.) is the first initiated of two clinical sites involved in this registered multi-site clinical study, along with Carle Foundation Hospital (Urbana, Illinois). The study is led by Dr. Diego Preciado, Children’s National, and Dr. Ryan Porter, Carle Hospital, along with a team of recognized otitis media experts at both clinical sites. This multi-center study plans to enroll a ...

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    16. University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives a 2019 NIH Grant for $487,053 for Understanding Otoacoustic Emissions. The principal investigator is Christopher Shera. The program began in 1999 and ends in 2024. Below is a summary of the proposed work. Realizing the potential of otoacoustic emissions (OAEs) as noninvasive probes of cochlear function requires understanding the physical and physiological mechanisms that generate and shape these sounds. To address important unresolved issues of cochlear mechanics while improving our understanding of OAE generation, we propose three aims involving innovative theoretical modeling rigorously tested by experimental measurements. The first Aim studies the action of ...

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    17. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives a 2019 NIH Grant for $408,735 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion ...

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    18. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2019 NIH Grant for $63,746 for Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for ...

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    19. University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives a 2019 NIH Grant for $670,541 for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes. The principal investigator is Brian Applegate. The program began in 2019 and ends in 2022. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin ...

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    20. Automated classification platform for the identification of otitis media using optical coherence tomography

      Automated classification platform for the identification of otitis media using optical coherence tomography

      The diagnosis and treatment of otitis media (OM), a common childhood infection, is a significant burden on the healthcare system. Diagnosis relies on observer experience via otoscopy, although for non-specialists or inexperienced users, accurate diagnosis can be difficult. In past studies, optical coherence tomography (OCT) has been used to quantitatively characterize disease states of OM, although with the involvement of experts to interpret and correlate image-based indicators of infection with clinical information. In this paper, a flexible and comprehensive framework is presented that automatically extracts features from OCT images, classifies data, and presents clinically relevant results in a user-friendly platform ...

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    21. Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Objectives Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. This study describes UVFP microanatomy and identifies possible vocal fold atrophy using OCT. Methods Three UVFP patients (ages 1, 11, and 17 years) underwent bilateral OCT imaging using a ...

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    22. Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Hypothesis: Ears with otosclerotic stapes fixation will exhibit lower-than-normal levels of ossicular mobility as measured by Optical Coherence Tomography Doppler Vibrometry (OCT-DV). Background: OCT-DV measures the vibration of middle ear structures in response to sound non-invasively through the intact tympanic membrane. This allows, in particular, direct measurement of the vibration at the lenticular process of the incus which is expected to be lower in patients with otosclerotic stapes fixation. Methods: OCT-DV was performed on ears presumptively diagnosed with otosclerosis (n = 13) and a group of normal control ears (n = 42). Displacement was measured at the umbo and the lenticular process ...

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    23. Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives a 2019 NIH Grant for $428,832 for Auditory Mechanics and Cochlear Amplification. The principal investigator is Elizabeth Olson. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. Sound input to the inner ear (cochlea) causes a frequency-segregated wave-pattern of sensory tissue motion that conveys sound information to the auditory neurons, leading to hearing. A currently untreatable aspect of hearing impairment is the deterioration of the cochlea's ability to sharply segregate sound by frequency. The cochlea's healthy frequency tuning is largely provided by the cochlear amplifier, an ...

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    1-24 of 326 1 2 3 4 ... 12 13 14 »
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