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Airway surface liquid depth imaged by surface laser reflectance microscopy
Explore Article The Journal of General Physiology (Aug 17 2010)
The thin layer of liquid at the surface of airway epithelium, the airway surface liquid (ASL), is important in normal airway physiology and in the pathophysiology of cystic fibrosis. At present, the best method to measure ASL depth involves scanning confocal microscopy after staining with an aqueous-phase fluorescent dye. We describe here a simple, noninvasive imaging method to measure ASL depth by reflectance imaging of an epithelial mucosa in which the surface is illuminated at a 45-degree angle by an elongated 13-µm wide rectangular beam produced by a 670-nm micro-focus laser. The principle of the method is that air–liquid, liquid–liquid, ...
Comment on Article Mentions: UCSF
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The effect of mandibular advancement on upper airway structure in obstructive sleep apnoea
Explore Article Thorax (Aug 4 2010)
Background The mechanisms by which mandibular advancement splints (MAS) improve obstructive sleep apnoea (OSA) are not well understood. This study aimed to evaluate the mechanism of action of MAS by assessing their effect on upper airway structure in patients with OSA. Methods Patients were recruited from a sleep disorders clinic for treatment with a custom-made MAS. MRI of the upper airway was performed during wakefulness in the supine position, with and without the MAS. Results Sixty-nine patients with OSA were recruited. Treatment with the MAS reduced the apnoea–hypopnoea index (AHI) from 27.0±14.7 events/h to 12.2±12.5 events/h (p<0.001). There was an ...
Comment on Article Mentions: University of Sydney
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Multimodal imaging guidance for laser ablation in tracheal stenosis
Explore Article www3.interscience.wiley.com (Jun 30 2010)
Objective/Hypothesis: Laser-induced damage of tracheal wall microstructures might contribute to recurrence after bronchoscopic treatment of tracheal strictures. The purpose of this study was to demonstrate how multimodal imaging using white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) might identify in vivo airway wall changes before and resulting from Nd:YAG laser ablation and dilation of tracheal stenosis. Study Design: Case study. Methods: Commercially available WLB, high frequency EBUS using a 20-MHz radial probe and time-domain, frontal imaging OCT systems were used to characterize the extent, morphology, and airway wall microstructures at the area of hypertrophic fibrotic tissue ...
Comment on Article Mentions: UC Irvine Matthew Brenner
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Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography
Explore Article SPIE Digital Library (Jun 30 2010)
There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea for clinical as well as fundamental studies. In this study, we explored, the feasibility of spectral domain optical coherence tomography (SD-OCT) for 3-D in vivo imaging of the cochlea in mice. The SD-OCT system employed in this study used a broadband light source centered at 1300 nm, and the imaging speed of the system was 47,000 A-scans per second using the InGaAs camera. The system was capable of providing fully processed, high-resolution B-scan images [512 (axial)×128 (lateral) pixels] at 280 ...
Comment on Article Mentions: Hrebesh M. Subhash Oregon Health & Science University Ruikang K. Wang
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In vivo 3D human vocal fold imaging with polarization sensitive optical coherence tomography and a MEMS scanning catheter
Explore Article opticsinfobase.org (Jun 23 2010)
We present in-vivo 3D human vocal fold images with polarization sensitive optical coherence tomography (PS-OCT). Characterizing the extent and location of vocal fold lesions provides useful information in guiding surgeons during phonomicrosurgery. Previous studies showed that PS-OCT imaging can distinguish vocal fold lesions from normal tissue, but these studies were limited to 2D cross-sectional imaging and were susceptible to sampling error. In-vivo 3D endoscopic imaging was performed by using a recently developed 2-axis MEMS scanning catheter and a spectral domain OCT (SD-OCT), running at 18.5 frames/s. Imaging was performed in the operating room with patients under general anesthesia and 3D ...
Comment on Article Mentions: B. Hyle Park Massachusetts General Hospital Harvard University
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Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography
Explore Article www3.interscience.wiley.com (Jun 18 2010)
Optical coherence tomography (OCT) can provide high-resolution ([sim]10-15 [mu]m/pixel) images of vocal fold microanatomy, as demonstrated previously. We explored physiologically triggered Fourier-domain OCT for imaging vocal folds during phonation. The goal is to visualize dynamic histological cross sections and four-dimensional data sets where multiple planes are displayed in synchronized motion. If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation.A Fourier-domain, triggered OCT system was created and tested in experiments on excised calf larynges to obtain preliminary observations and characterize important factors affecting image quality.Larynges were imaged during phonation driven by warm, humidified ...
Comment on Article Mentions: Seok-Hyun Yun Massachusetts General Hospital Harvard University
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State of the art laryngeal imaging: research and clinical implications
Explore Article LWW Online (May 14 2010)
Purpose of review: This study provides a review of the latest advances in videostroboscopy, videokymography and high-speed videoendoscopy, and outlines the development of new laryngeal imaging modalities based on optical coherence tomography, laser-depth kymography, and magnetic resonance imaging (MRI), published in the past 2 years. Recent findings: Videostroboscopy and videokymography: Image quality has improved and several image processing and measurement techniques have been published. High-speed videoendoscopy: Significant progress has been made through increased sensitivity and frame rates of the cameras, and the development of facilitative playbacks, phonovibrography and several image segmentation and measurement methods. Clinical evidence was presented through applications ...
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Optical Coherence Tomography of the Larynx Using the Niris System
Explore Article BCDecker (Mar 15 2010)
OBJECTIVES:To present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.METHODS:Using the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 μm and a depth scanning range of 2.2 mm, obtaining images of 200 × 200 pixels ...
Comment on Article Mentions: Imalux Zhongping Chen Jeong H. Kim
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An optical coherence tomography study for imaging the round window niche and the promontorium tympani
Explore Article SPIE Digital Library (Mar 2 2010)
An optical coherence tomography study for imaging the round window niche and the promontorium tympani Tympanosclerosis may involve the tympanic membrane, the ossicles, and the oval and round window niche, respectively. The surgical treatment of the obliterated oval window niche is most challenging. Beside stapesplasty, vibroplasty coupling the floating mass transducer (FMT) onto the round window niche and into a new, so-called third window is indicated. In the latter situation, drilling a hole into the promontorium is necessary to couple the FMT close to the membranous endosteum. Damage of the membranous inner ear must be avoided. The question was whether ...
Comment on Article Mentions: Universität Rostock
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Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT)
Explore Article SPIE Digital Library (Mar 2 2010)
Optical coherence tomography (OCT) is a promising method in the early diagnosis of oral cavity cancer. The objective of the present study is to determine normal values of epithelial thickness in the oral cavity, as no such data are to be found in the literature. In healthy test persons, epithelial thickness of the oral mucosa was determined with the help of OCT separately for each side at nine different locations. Special attention was directed to those sites having the highest incidence for the development of dysplasias and carcinomas. Depending on the location within the oral cavity, the epithelium demonstrated a ...
Comment on Article Mentions: Ludwig Maximilians Universität München
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Emerging applications for OCT in the head and neck
Explore Article SPIE Digital Library (Mar 2 2010)
Objectives: To describe the current and promising new applications of Optical Coherence Tomography (OCT) as a helpful tool when imaging the different sites in the head and neck. We used the OCT Niris system, which is the first commercially available OCT device for applications outside the field of ophthalmology. Methods: OCT images were obtained of normal, benign, premalignant and malignant lesions in different areas of the head and neck. The OCT imaging system has a tissue penetration depth of approximately 1-2mm, a scanning range of 2mm and a spatial depth resolution of approximately 10-20µm. Imaging was performed using a flexible ...
Comment on Article Mentions: Zhongping Chen UC Irvine Imalux Niris
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Overcoming barriers in topical administration of gold nanoparticles for optical coherence tomography using multimodal delivery
Explore Article SPIE Digital Library (Feb 19 2010)
Optical coherence tomography (OCT) is a non-invasive and promising imaging modality with high resolution that is an order of magnitude higher than current diagnostic techniques. However, its use in detecting early-stage cancer is limited due to insufficient contrast level in biological tissue, which can be enhanced by harnessing contrast agents [e.g., gold nanoparticles (Au NPs)]. Enhanced penetration by creating micropassages and distribution by ultrasonic force (multimodal topical delivery) was proven to overcome two major barriers (stratum corneum and epithelial barriers) in topically administering Au NPs using an in vivo oral dysplasia hamster model (overall 150% enhanced OCT contrast). Expanded progress ...
Comment on Article Mentions: Zhongping Chen UC Irvine Petra Wilder-Smith
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Optical and molecular techniques to identify tumor margins within the larynx
Explore Article www3.interscience.wiley.com (Jan 22 2010)
Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of ...
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Cervical Soft Tissue Motion Measurement by Optical Coherence Tomography
Explore Article SpringerLink Home (Jan 1 2010)
To design a semi-automatic laser scalpel for tissue resection in the area of neck masses it was necessary to examine the biomechanic behavour of these tissues. The aim was to identify if and to what extent (amplitude and velocity) the tissues shift due to respiration and circulation. This is important since these movements have to be followed by the laser scalpel. At defined points on the neck surface onedimensional (1-D) time related Optical Coherence Tomography OCT measurements were recorded. Tissue shifting in the direction of the OCT-sightaxis was quantified. The preliminary results of these basic experiments shown here will be ... -
Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations
Explore Article SPIE Digital Library (Dec 16 2009)
We have developed a novel dual-window approach for spectroscopic optical coherence tomography (OCT) measurements and applied it to probe nuclear morphology in tissue samples drawn from the hamster cheek pouch carcinogenesis model. The dual-window approach enables high spectral and depth resolution simultaneously, allowing detection of spectral oscillations, which we isolate to determine the structure of cell nuclei in the basal layer of the epithelium. The measurements were executed with our parallel frequency domain OCT system, which uses light from a thermal source, providing high bandwidth and access to the visible portion of the spectrum. The structural measurements show a highly ...Comment on Article Mentions: Duke University Robert N. Graf Francisco E. Robles
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Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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