1. Articles in category: Otolaryngology

    1-24 of 399 1 2 3 4 ... 15 16 17 »
    1. Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear's ...

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    2. Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography

      Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography

      Significance: The human vocal fold (VF) oscillates in multiple vectors and consists of distinct layers with varying viscoelastic properties that contribute to the mucosal wave. Office-based and operative laryngeal endoscopy are limited to diagnostic evaluation of the VF epithelial surface only and are restricted to axial-plane characterization of the horizontal mucosal wave. As such, understanding of the biomechanics of human VF motion remains limited. Aim: Optical coherence tomography (OCT) is a micrometer-resolution, high-speed endoscopic imaging modality which acquires cross-sectional images of tissue. Our study aimed to leverage OCT technology and develop quantitative methods for analyzing the anatomy and kinematics of ...

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    3. When It Comes to Innovation, This Researcher Is All Ears

      When It Comes to Innovation, This Researcher Is All Ears

      It’s a perennial pediatric problem: more than 80 percent of children will have at least one ear infection by their third birthday. Beyond the pain and irritability that an ear infection can bring — for both children and their parents alike — untreated or recurring infections can result in hearing loss, which may affect the development of speech and language skills. With nearly 20 million estimated cases of acute middle ear infections each year in the United States, the annual cost associated with this condition is estimated to exceed $4 billion. “It’s a universally understood misery, this issue of chronic ...

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    4. Handheld device for identification of microbiological constituents in the middle ear

      Handheld device for identification of microbiological constituents in the middle ear

      Methods and apparatus for identifying microbiological constituents in the middle ear. A spectrometer receives Raman-scattered light from the region of the tympanic membrane and resolves spectral features of the Raman-scattered light. A processor receives the interferometry signal and the Raman signal, and generates a Raman spectrum of the tympanic membrane and material adjacent thereto. In some embodiments of the invention, low-coherence light and substantially monochromatic excitation light are directed onto a tympanic membrane of the ear of a person via an otoscopic tip that abuts the ear canal. An interferometer combines scattered low-coherence light from the ear tissue with a ...

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    5. In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

      In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

      We describe an optical coherence tomography and vibrometry system designed for portable hand-held usage in the otology clinic on awake patients. The system provides clinically relevant point-of-care morphological imaging with 14-44 µm resolution and functional vibratory measures with sub-nanometer sensitivity. We evaluated various new approaches for extracting functional information including a multi-tone stimulus, a continuous chirp stimulus, and alternating air and bone stimulus. We also explored the vibratory response over an area of the tympanic membrane (TM) and generated TM thickness maps. Our results suggest that the system can provide real-time in vivo imaging and vibrometry of the ear and ...

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    6. Oregon Health & Science University Receives NIH Grant for The Mechanical and Ionic Roles of Cochlear fluids in Hearing and Hearing Loss

      Oregon Health & Science University Receives NIH Grant for The Mechanical and Ionic Roles of Cochlear fluids in Hearing and Hearing Loss

      Oregon Health & Science University Receives a 2021 NIH Grant for $593,243 for The Mechanical and Ionic Roles of Cochlear fluids in Hearing and Hearing Loss. The principal investigator is Alfred Nuttal. Below is a summary of the proposed work. A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti tune the sound induced vibration of the organ of Corti. A process known as cochlear amplification (CA), now the subject of intense work around the world, has critical components not yet studied. Two questions of broad interest that this proposal address are ...

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    7. UIUC Receives NIH Grant for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis Media

      UIUC Receives NIH Grant for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis Media

      University of Illinois at Urbana-Champaign Receives a 2021 NIH Grant for $653,667 for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis Media. The principal investigator is Yan Li. Below is a summary of the proposed work. Otitis media (middle ear infection) is a highly prevalent disease, especially in young children. It has been documented that more than 75% of children will have at least one episode of otitis media (OM) by age 3, and many children will have recurrent or chronic OM. In most cases, diagnosis of an ear infection is performed ...

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    8. University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives a 2021 NIH Grant for $625,265 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex biomechanics of the 3D multi-cellular and acellular arrangement that ...

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    9. Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil

      Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil

      Studying the in-vivo mechanical and electrophysiological cochlear responses in several species helps us to have a comprehensive view of the sensitivity and frequency selectivity of the cochlea. Different species might use different mechanisms to achieve the sharp frequency-place map. The outer hair cells (OHC) play an important role in mediating frequency tuning. In the present work, we measured the OHC-generated local cochlear microphonic (LCM) and the motion of different layers in the organ of Corti using optical coherence tomography (OCT) in the first turn of the cochlea in guinea pig. In the best frequency (BF) band, our observations were similar ...

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    10. Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections

      Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections

      This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open Access Article Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections by Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA 2 Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA 3 Department of Otolaryngology, Carle Foundation Hospital, Champaign, IL 61822, USA 4 Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA 5 Department of Electrical and Computer Engineering, University of Illinois ...

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    11. Watching Death in the Gerbil Cochlea Using Optical Coherence Tomography (OCT)

      Watching Death in the Gerbil Cochlea Using Optical Coherence Tomography (OCT)

      Because it is difficult to directly observe the morphology of the living cochlea, our ability to infer the mechanical functioning of the living ear has been limited. Nearly all of our knowledge about cochlear morphology comes from postmortem tissue that was fixed and processed using procedures that possibly distort the structures and fluid spaces of the organ of Corti. In this study, optical coherence tomography was employed to obtain in vivo and postmortem micron-scale volumetric images of the high-frequency hook region of the gerbil cochlea through the round-window membrane. The anatomical structures and fluid spaces of the organ of Corti ...

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    12. Investigations on the potential of optical coherence tomography as an imaging tool for eustachian tube

      Investigations on the potential of optical coherence tomography as an imaging tool for eustachian tube

      The purpose of this study was to explore the feasibility of eustachian tube optical coherence tomography (ET-OCT) for imaging the pharyngeal region of the eustachian tube (ET). Ten subjects with ear complaints underwent ET-OCT guided by nasal endoscopy, and ET-OCT examination was performed on both sides of each subject's ETs. The process and resulting images were analysed. Ten subjects ranging from 21 to 73 years old (45 ± 14.77) were enrolled in this study. Eighteen ET-OCT imaging examinations were completed. The mean duration of each examination was 2.80 ± 1.62 min (ranging from 2 to 7 min). There ...

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    13. Utilization potential of intraluminal optical coherence tomography for the Eustachian tube

      Utilization potential of intraluminal optical coherence tomography for the Eustachian tube

      Imaging the Eustachian tube is challenging because of its complex anatomy and limited accessibility. This study fabricated a fiber-based optical coherence tomography (OCT) catheter and investigated its potential for assessing the Eustachian tube anatomy. A customized OCT system and an imaging catheter, termed the Eustachian OCT, were developed for visualizing the Eustachian tube. Three male swine cadaver heads were used to study OCT image acquisition and for subsequent histologic correlation. The imaging catheter was introduced through the nasopharyngeal opening and reached toward the middle ear. The OCT images were acquired from the superior to the nasopharyngeal opening before and after ...

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    14. Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

      Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

      Objectives/hypothesis: Identifying distinctive features of the vocal fold (VF) during development could have significant clinical implications for treating voice disorders. This study investigates the structural organization of the VF microanatomy across gender and age groups using optical coherence tomography (OCT). Study design: Prospective clinical trial. Materials and methods: In vivo OCT images were acquired from 97 patients (58 males and 39 females) aged between 6 weeks and 27 years. All patients showed no signs of vocal fold pathology on endoscopy. Morphological features were extracted from OCT images and statistically compared between age groups. This study was performed at Massachusetts ...

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    15. PhotoniCare Announces Rebranding of First-in-Class Technology for Imaging the Middle Ear, Now called OtoSight Middle Ear Scope

      PhotoniCare Announces Rebranding of First-in-Class Technology for Imaging the Middle Ear, Now called OtoSight Middle Ear Scope

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing healthcare providers with better diagnostic tools, today announced that it is rebranding its middle ear scope to OtoSight™ Middle Ear Scope (formerly TOMi ™ Scope). In preparation for the 2021 commercial launch, the OtoSight™ Middle Ear Scope brand name is well-positioned to convey the product’s unique ability to non-invasively see through the eardrum and assess the middle ear space. Using optical coherence tomography (OCT) high resolution depth imaging, OtoSight™ Middle Ear Scope helps to determine the presence or absence of fluid in the middle ear and to characterize the fluid ...

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      Mentions: PhotoniCare
    16. Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy

      Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy

      Studying the impact of antibiotic treatment on otitis media (OM), the leading cause of primary care office visits during childhood, is critical to develop appropriate treatment strategies. Tracking dynamic middle ear conditions during antibiotic treatment is not readily applicable in patients, due to the limited diagnostic techniques available to detect the smaller amount and variation of middle ear effusion (MEE) and middle ear bacterial biofilm, responsible for chronic and recurrent OM. To overcome these challenges, a handheld optical coherence tomography (OCT) system has been developed to monitor in vivo response of biofilms and MEEs in the OM-induced chinchilla model, the ...

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    17. Mammalian Cochlear Hair Cell Imaging Using Optical Coherence Tomography (OCT): A Preliminary Study

      Mammalian Cochlear Hair Cell Imaging Using Optical Coherence Tomography (OCT): A Preliminary Study

      Objectives: This study aimed to investigate the feasibility of using optical coherence tomography (OCT) to provide information about cochlear microanatomy at a cellular level, specifically of cochlear hair cells in mammals. Materials and methods: A total of 10 Sprague-Dawley rats were divided into 2 experimental groups for comparing the arrangement of normal and damaged hair cells. Postnatal day 3 Sprague-Dawley rats were used to test the swept-source OCT system, and the images recorded were compared with fluorescence microscope images. Results: Intracochlear structures (the inner hair cells, outer hair cells, and auditory nerve fibers) were clearly visualized at the individual cellular ...

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    18. Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

      Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

      Identifying distinct normal extracellular matrix (ECM) features from pathology is of the upmost clinical importance for laryngeal diagnostics and therapy. Despite remarkable histological contributions, our understanding of the vocal fold (VF) physiology remains murky. The emerging field of non-invasive 3D optical imaging may be well-suited to unravel the complexity of the VF microanatomy. This study focused on characterizing the entire VF ECM in length and depth with optical imaging. A quantitative morphometric evaluation of the human vocal fold lamina propria using two-photon excitation fluorescence (TPEF), second harmonic generation (SHG), and optical coherence tomography (OCT) was investigated. Fibrillar morphological features, such ...

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    19. Clinical Development of Deep Learning for the TOMi Scope

      Clinical Development of Deep Learning for the TOMi Scope

      The objective of this study is to clinically develop and evaluate a machine learning approach to improve the performance and data interpretation of the PhotoniCare TOMi Scope in pediatric patients presenting at the primary care office for suspected ear infections. In this observational study, results of TOMi Scope imaging will not affect patient standard of care.

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      Mentions: PhotoniCare
    20. In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography

      In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography

      Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral-domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. A novel approach based on quantitative parameters is presented to characterize spatial and temporal variations of the dynamic TM motion. Furthermore, the TM ...

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    21. Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model

      Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model

      BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord cause changes in the voice. Polarization-sensitive optical coherence tomography (PS-OCT) enables phase retardation measurement to evaluate birefringence of tissue with varied organization of collagen fibers in different tissue layers. Therefore ...

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    22. University of Southern California Receives NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a 2021 NIH Grant for $606,342 for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    23. Efficacy of endotracheal tube suctioning in intubated intensive care unit patients determined by in vivo catheter-based optical coherence tomography—a pilot study

      Efficacy of endotracheal tube suctioning in intubated intensive care unit patients determined by in vivo catheter-based optical coherence tomography—a pilot study

      Background: Mechanical ventilation using an endotracheal tube (ETT) is one of the critical interventions given to patients in the intensive care unit (ICU). ETTs are associated with the formation of biofilms, placing patients at increased risk for developing ventilator-associated pneumonia (VAP). ETT suctioning is used to remove secretions, reduce bacterial colonization, and reduce the rate of biofilm formation. However, current standard-of-care suctioning procedures do not adequately eliminate all secretions from the ETT. Methods: This observational study was conducted in a cohort of 4 subjects admitted to the ICU and intubated with an ETT, irrespective of ethnicity, gender, or race. A ...

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    1-24 of 399 1 2 3 4 ... 15 16 17 »
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