Popular Articles
-
OCT Companies in the News
-
OCT Products in the News
-
Organizations in the News
(9 articles) University of Western Australia
(7 articles) University of Lübeck
(7 articles) Universität Rostock
(6 articles) Laser Zentrum Hannover
(5 articles) Sir Charles Gairdner Hospital
(2 articles) Harvard University
(1 articles) National Center for Geriatrics and Gerontology in Japan
-
People in the News
(7 articles) William B. Armstrong
(7 articles) Peter R. Eastwood
-
Optical Coherence Tomography of the Larynx Using the Niris System
Explore Article BCDecker (3 hours, 18 min ago) Otolaryngology
OBJECTIVES:To present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.METHODS:Using the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 μm and a depth scanning range of 2.2 mm, obtaining images of 200 × 200 pixels ...
Comment on Article Mentions: Imalux Zhongping Chen Jeong H. Kim
-
Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT)
Explore Article SPIE Digital Library (Mar 2 2010) Oncology , Otolaryngology
Optical coherence tomography (OCT) is a promising method in the early diagnosis of oral cavity cancer. The objective of the present study is to determine normal values of epithelial thickness in the oral cavity, as no such data are to be found in the literature. In healthy test persons, epithelial thickness of the oral mucosa was determined with the help of OCT separately for each side at nine different locations. Special attention was directed to those sites having the highest incidence for the development of dysplasias and carcinomas. Depending on the location within the oral cavity, the epithelium demonstrated a ...
Comment on Article Mentions: Ludwig Maximilians Universität München
-
Emerging applications for OCT in the head and neck
Explore Article SPIE Digital Library (Mar 2 2010) Otolaryngology
Objectives: To describe the current and promising new applications of Optical Coherence Tomography (OCT) as a helpful tool when imaging the different sites in the head and neck. We used the OCT Niris system, which is the first commercially available OCT device for applications outside the field of ophthalmology. Methods: OCT images were obtained of normal, benign, premalignant and malignant lesions in different areas of the head and neck. The OCT imaging system has a tissue penetration depth of approximately 1-2mm, a scanning range of 2mm and a spatial depth resolution of approximately 10-20µm. Imaging was performed using a flexible ...
Comment on Article Mentions: Zhongping Chen UC Irvine Imalux Niris
-
Overcoming barriers in topical administration of gold nanoparticles for optical coherence tomography using multimodal delivery
Explore Article SPIE Digital Library (Feb 19 2010) Oncology , Otolaryngology
Optical coherence tomography (OCT) is a non-invasive and promising imaging modality with high resolution that is an order of magnitude higher than current diagnostic techniques. However, its use in detecting early-stage cancer is limited due to insufficient contrast level in biological tissue, which can be enhanced by harnessing contrast agents [e.g., gold nanoparticles (Au NPs)]. Enhanced penetration by creating micropassages and distribution by ultrasonic force (multimodal topical delivery) was proven to overcome two major barriers (stratum corneum and epithelial barriers) in topically administering Au NPs using an in vivo oral dysplasia hamster model (overall 150% enhanced OCT contrast). Expanded progress ...
Comment on Article Mentions: Zhongping Chen UC Irvine Petra Wilder-Smith
-
Optical and molecular techniques to identify tumor margins within the larynx
Explore Article www3.interscience.wiley.com (Jan 22 2010) Otolaryngology
Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of ...
-
Cervical Soft Tissue Motion Measurement by Optical Coherence Tomography
Explore Article SpringerLink Home (Jan 1 2010) Gynecology , Oncology , Otolaryngology
To design a semi-automatic laser scalpel for tissue resection in the area of neck masses it was necessary to examine the biomechanic behavour of these tissues. The aim was to identify if and to what extent (amplitude and velocity) the tissues shift due to respiration and circulation. This is important since these movements have to be followed by the laser scalpel. At defined points on the neck surface onedimensional (1-D) time related Optical Coherence Tomography OCT measurements were recorded. Tissue shifting in the direction of the OCT-sightaxis was quantified. The preliminary results of these basic experiments shown here will be ... -
Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations
Explore Article SPIE Digital Library (Dec 16 2009) Oncology , Otolaryngology
We have developed a novel dual-window approach for spectroscopic optical coherence tomography (OCT) measurements and applied it to probe nuclear morphology in tissue samples drawn from the hamster cheek pouch carcinogenesis model. The dual-window approach enables high spectral and depth resolution simultaneously, allowing detection of spectral oscillations, which we isolate to determine the structure of cell nuclei in the basal layer of the epithelium. The measurements were executed with our parallel frequency domain OCT system, which uses light from a thermal source, providing high bandwidth and access to the visible portion of the spectrum. The structural measurements show a highly ...Comment on Article Mentions: Duke University Robert N. Graf Francisco E. Robles
-
Morphologic Classification of Reinke's Edema through Optical Coherence Tomography
Explore Article Thieme (Dec 11 2009) Otolaryngology
OBJECTIVE: Several classification systems for Reinke's edema have been proposed in the past, which are somewhat less than morphologically ideal. The objective of the present study is to evaluate the ability of optical coherence tomography (OCT) to attain a reproducible graduation of Reinke's edema. MATERIAL AND METHODS: In a prospective study, 30 consecutive patients underwent endolaryngeal, microsurgical resection of their Reinke's edema. Graduation was performed through OCT based on morphologic criteria, where each result was compared with that of other classification systems. RESULTS: In Reinke's edema grade I according to Glanz, a feathered pattern is found, while Reinke's edema grade ...Comment on Article Mentions: Henning Wisweh Laser Zentrum Hannover Holger Lubatschowski
-
Office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography
Explore Article SPIE Digital Library (Dec 2 2009) Otolaryngology
Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient index (GRIN) lens–based probe capable of capturing images of the human larynx by use of swept-source OCT during a typical office-based laryngoscopy examination is presented. In vivo OCT imaging of the human larynx is demonstrated with a rate of 40 frames per second. Dynamic vibration of the vocal folds is recorded to provide not only high-resolution cross-sectional tissue structures but also vibration parameters, such as the vibration frequency and magnitude of the ...Comment on Article Mentions: Zhongping Chen UC Irvine Marc Rubinstein
-
Laryngeal epithelial thickness: a comparison between optical coherence tomography and histology
Explore Article www3.interscience.wiley.com (Oct 3 2009) Otolaryngology
Objectives: Optical coherence tomography, an imaging modality using near-infrared light, produces cross-sectional tissue images with a lateral pixel resolution of 10 μm. However, normative data is first needed on epithelial thickness for lesion characterisation, and, to date, little exists. The purpose of our study is to measure normal laryngeal epithelial thickness by in vivo optical coherence tomography, and compare these values to those obtained from fixed ex-vivo laryngectomy specimens. Design and Setting: Prospective at a single medical center in California, United States. Participants: A total of 116 patients undergoing operative endoscopy. Main outcome measures: Optical coherence tomography images of clinically ...Comment on Article Mentions: Zhongping Chen Shuguang Guo UC Irvine
-
Developmental Aspects of the Upper Airway
Explore Article pats.atsjournals.org (Sep 10 2009) Bronchoscopy , Otolaryngology
The upper airway serves three important functions: respiration, swallowing, and speech. During development it undergoes significant structural and functional changes that affect its size, shape, and mechanical properties. Abnormalities of the upper airway require prompt attention, because these often alter ventilatory patterns and gas exchange, particularly during sleep when upper airway motor tone and ventilatory drive are diminished. Recognizing the relationship of early life events to lung health and disease, the National Heart, Lung, and Blood Institute (NHLBI), with cofunding from the Office of Rare Diseases (ORD), convened a workshop of extramural experts, from many disciplines. The objective of the ...Comment on Article Mentions: University of Wisconsin University of Maryland Johns Hopkins University
-
A laryngoscope for office-based imaging of human vocal folds using OCT
Explore Article Home: SPIE.org (Sep 7 2009) Otolaryngology
We developed a laryngoscope with an integrated OCT beam path for office-based non-contact imaging of human vocal folds. In combination with conventional videolaryngoscopy superficial and subsurface lesions can be detected. For error-free interpretation of OCT images obtained in office-based examination motion artifacts have to be considered. To demonstrate the implications on OCT images we simulated probe and patient movements for different commercial systems representing the three OCT modalities and analyzed the OCT data. Our results show that time domain and fourier domain OCT with a swept light source are probably better suited for noncontact imaging of awake patients than the ...Comment on Article Mentions: Henning Wisweh Laser Zentrum Hannover Holger Lubatschowski
-
Optical coherence tomography applications in otolaryngology
Explore Article Elsevier (Sep 5 2009) Otolaryngology
(Article Available in English) Optical coherence tomography is a novel imaging technique providing high-resolution bidimensional images of tissue microstructures. Several studies have been published on the use of this technique in different fields of medicine, particularly ophthalmology. There are very few studies in the field of otolaryngology. This paper presents various applications of optical coherence tomography in the different sub-specialties of otolaryngology, as well as the benefits of this technique over traditional diagnostic methods.
Comment on Article Mentions: UC Irvine Marc Rubinstein Brian J. Wong
-
In vivo imaging of human labial glands using advanced optical coherence tomography
Explore Article ooooe.net (Sep 1 2009) Otolaryngology
Objective Optical coherence tomography (OCT) has emerged as a high-resolution noninvasive clinical imaging application. The purpose of this study was to show OCT images of human labial glands obtained using a swept-source (SS) OCT system. Study design Labial gland OCT imaging was carried out using our new SS-OCT system for 5 healthy volunteers using a hand-held in vivo OCT scanning probe. The labial tissue was scanned in a superior to inferior direction in 2 and 3 dimensions. Results The resulting 2- and 3-dimensional ultrahigh-resolution images of in vivo OCT human labial minor salivary glands revealed the epithelium, connective tissue, lobes, ...Comment on Article Mentions: Santec Changho Chong Nobuyoshi Ozawa
-
Real-time tracking of vocal fold injections with optical coherence tomography
Explore Article www3.interscience.wiley.com (Aug 14 2009) Otolaryngology
Abstract Objectives/Hypothesis: Optical coherence tomography (OCT) is a promising new imaging modality that can help discern the layered microstructure of vocal folds. In the future, subepithelial injections of implants will improve vocal fold pliability where there is stiffness of phonatory mucosa. Using OCT both to delineate the depth of subepithelial injections real-time and to serially image the implant over time would be valuable, and has not been demonstrated previously. Study Design: Ex vivo study using excised calf larynges and survival study using canines in vivo. Methods: An investigation was done employing real-time OCT imaging of subepithelial injection pulses into phonatory ...Comment on Article Mentions: Johannes F. de Boer Massachusetts General Hospital Harvard University
RSS Feed
Recent Comments
Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
See all recent comments