1. Articles in category: Otolaryngology

    1-24 of 424 1 2 3 4 ... 16 17 18 »
    1. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions

      Massachusetts Eye and Ear Infirmary Received a 2022 NIH Grant for $117,133 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

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    2. University of Southern California Receives NIH Grant for Cochlear mechanics in the mouse

      University of Southern California Receives NIH Grant for Cochlear mechanics in the mouse

      University of Southern California Received a 2022 NIH Grant for $623,326 for Cochlear mechanics in the mouse. The principal investigator is John Oghalai. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex biomechanics of the 3D multi-cellular and acellular arrangement that ...

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    3. Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Optical coherence tomography (OCT) has become an important tool for measuring the vibratory response of the living cochlea. It stands alone in its capacity to measure the intricate motion of the hearing organ through the surrounding otic capsule bone. Nevertheless, as an extension of phase-sensitive OCT, it is only capable of measuring motion along the optical axis. Hence, measurements are 1-D. To overcome this limitation and provide a measure of the 3-D vector of motion in the cochlea, we developed an OCT system with three sample arms in a single interferometer. Taking advantage of the long coherence length of our ...

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    4. Infrared otoscope for characterization of effusion

      Infrared otoscope for characterization of effusion

      An otoscope uses differential reflected response of optical energy at an absorption range and an adjacent wavelength range to determine the presence of water (where the wavelengths are water absorption wavelength and adjacent non-absorption excitation wavelengths). In another example of the invention, the otoscope utilizes OCT in combination with absorption and non-absorption range for bacteria and water.

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    5. Coherent Optical Detection of Middle Ear Disease

      Coherent Optical Detection of Middle Ear Disease

      Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States, affects 90% of all children, and is the most common indication for antimicrobial therapy and surgery in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity. OM continues as the most common cause of hearing loss in children and leads to speech, educational and other developmental delays. OM causes life-threatening complications and is expensive, resulting in over $5 billion annually in U.S. health care expenditures. Despite the ...

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    6. OCT Engineering Manager Opening at PhotoniCare

      OCT Engineering Manager Opening at PhotoniCare

      PhotoniCare is a fast-growing VC funded MedTech company with a mission to improve health outcomes using cutting edge technology. We have developed the first FDA-cleared OCT-based imaging system, OtoSight Middle Ear Scope, for assisting diagnosis of ear infections, a condition that affects 80% of children. The company operates with a philosophy of providing a fun, exciting and collaborative work environment for all team members. PhotoniCare also makes dedicated efforts towards professional and personal growth of all its team. We are looking for an engineering manager specializing in OCT to join our team and help shape the platform that will enable ...

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      Mentions: FDA PhotoniCare
    7. UIUC Receives a 2022 NIH Grant f for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis Media

      UIUC Receives a 2022 NIH Grant f for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis Media

      University of Illinois at Urbana-Champaign Received a 2022 NIH Grant for $567,377 for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis Media. The principal investigator is Stephan Boppart. Below is a summary of the proposed work. Otitis media (middle ear infection) is a highly prevalent disease, especially in young children. It has been documented that more than 75% of children will have at least one episode of otitis media (OM) by age 3, and many children will have recurrent or chronic OM. In most cases, diagnosis of an ear infection is performed ...

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    8. Optical coherence tomography spurs quantum leap in hearing research

      Optical coherence tomography spurs quantum leap in hearing research

      Nam is using the same tool that helped ophthalmologists achieve major advances in vision correction. Optical coherence tomography is an imaging technique that allows researchers to capture micrometer-resolution, two- and three-dimensional images from within biological tissues. The technology has provided a quantum leap forward in cochlear research, says Nam, whose lab occupies a unique niche in the field. Other research groups use the imaging technology to study the vibration of cochlear tissues in live animals. However, the optical beam loses power as it moves through skin and bone. Instead, Nam’s group images the cochlear tissues in a specially designed ...

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    9. Using volumetric optical coherence tomography to achieve spatially resolved organ of Corti vibration measurements

      Using volumetric optical coherence tomography to achieve spatially resolved organ of Corti vibration measurements

      Optical coherence tomography (OCT) has become a powerful tool for measuring vibrations within the organ of Corti complex (OCC) in cochlear mechanics experiments. However, the one-dimensional nature of OCT measurements, combined with experimental and anatomical constraints, make these data ambiguous: Both the relative positions of measured structures and their orientation relative to the direction of measured vibrations are not known a priori . We present a method by which these measurement features can be determined via the use of a volumetric OCT scan to determine the relationship between the imaging/measurement axes and the canonical anatomical axes. We provide evidence that ...

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    10. Cochlear Fluid Spaces and Structures of the Gerbil High-Frequency Region Measured Using Optical Coherence Tomography (OCT)

      Cochlear Fluid Spaces and Structures of the Gerbil High-Frequency Region Measured Using Optical Coherence Tomography (OCT)

      Since it has been difficult to directly observe the morphology of the living cochlea, our ability to infer the mechanical functioning of the living ear has been limited. Nearly all our knowledge about cochlear morphology comes from postmortem tissue that was fixed and processed using procedures that possibly distort the structures and fluid spaces of the organ of Corti. In this study, optical coherence tomography was employed to obtain volumetric images of the high-frequency hook region of the gerbil cochlea, as viewed through the round window, with far better resolution capability than had been possible before. The anatomical structures and ...

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    11. University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

      University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

      University of Southern California Received a 2022 NIH Grant for $516,925 for Mechanisms of cochlear synaptopathy after noise or blast trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    12. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      Massachusetts Eye and Ear Infirmary Received a 2022 NIH Grant for $488,619 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

      Read Full Article
    13. Medical College of Wisconsin Receives 2022 NIH Grant for Otitis Media Diagnosis and Treatment

      Medical College of Wisconsin Receives 2022 NIH Grant for Otitis Media Diagnosis and Treatment

      Medical College of Wisconsin received a 2022 NIH Grant for $576,383 for Otitis Media Diagnosis and Treatment. The principal investigator is Joseph Kerchner. Below is a summary of the proposed work. Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States (1,2), affects 90% of all children (3,4) and is the most common indication for antimicrobial therapy and surgery (5) in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity (1,3,6-30). OM continues ...

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    14. University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes

      University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes

      University of Southern California received a 2022 NIH Grant for $586,520 for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin growth in the middle ear which facilitates erosion of ...

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    15. Localized vibrations incorporated thickness assessment of cadaveric tympanic membranes using Doppler-optical coherence tomography

      Localized vibrations incorporated thickness assessment of cadaveric tympanic membranes using Doppler-optical coherence tomography

      Vibrations of the tympanic membrane (TM) play a key role in the diagnosis of the middle ear in hearing research. The thickness is one of the factors that determines performance analysis of the TM and plays an important role in forming vibration patterns. When the thickness of TM is changed for various reasons, the vibration pattern is also changed, which interferes with sound transmission. The previously reported studies of measuring TM obtained the response of the entire or at a single point to understand the characteristics of the TM, which is limited to providing detailed information for the region of ...

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    16. New Approaches and Technologies to Improve Accuracy of Acute Otitis Media Diagnosis

      New Approaches and Technologies to Improve Accuracy of Acute Otitis Media Diagnosis

      Several studies have shown that in recent years incidence of acute otitis media (AOM) has declined worldwide. However, related medical, social, and economic problems for patients, their families, and society remain very high. Better knowledge of potential risk factors for AOM development and more effective preventive interventions, particularly in AOM-prone children, can further reduce disease incidence. However, a more accurate AOM diagnosis seems essential to achieve this goal. Diagnostic uncertainty is common, and to avoid risks related to a disease caused mainly by bacteria, several children without AOM are treated with antibiotics and followed as true AOM cases. The main ...

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    17. PhotoniCare Announces ISO 13485:2016 Certification

      PhotoniCare Announces ISO 13485:2016 Certification

      PhotoniCare, Inc.—a company revolutionizing frontline care with the OtoSight Middle Ear Scope that uses OCT technology to increase the objective accuracy of fluid assessment in the middle ear—announced that they have successfully completed their ISO 13485:2016 certification today. ISO 13485:2016 is an internationally recognized quality standard that specifies requirements for a quality management system used by an organization demonstrating its ability to provide medical devices and related services that consistently meet strict regulatory and customer requirements. The Quality Management System PhotoniCare utilizes to design, manufacture, and service OtoSight Middle Ear Scopes has officially been audited and ...

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    18. An outer hair cell-powered global hydromechanical mechanism for cochlear amplification

      An outer hair cell-powered global hydromechanical mechanism for cochlear amplification

      It is a common belief that the mammalian cochlea achieves its exquisite sensitivity, frequency selectivity, and dynamic range through an outer hair cell-based active process, or cochlear amplification. As a sound-induced traveling wave propagates from the cochlear base toward the apex, outer hair cells at a narrow region amplify the low level sound-induced vibration through a local feedback mechanism. This widely accepted theory has been tested by measuring sound-induced sub-nanometer vibrations within the organ of Corti in the sensitive living cochleae using heterodyne low-coherence interferometry and optical coherence tomography. The aim of this short review is to summarize experimental findings ...

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    19. Anatomic Optical Coherence Tomography (aOCT) for Evaluation of the Internal Nasal Valve

      Anatomic Optical Coherence Tomography (aOCT) for Evaluation of the Internal Nasal Valve

      Objectives/hypothesis: To establish the utility of anatomic optical coherence tomography (aOCT) in evaluating internal nasal valve (INV). Study design: Anatomic specimen imaging study. Methods: Fresh-harvested human specimen heads were evaluated using both computed tomography (CT) imaging as well as using aOCT. Scans were performed at three time points: 1) After septoplasty for cartilage harvest, 2) after placement of butterfly graft (BFG), and 3) after placement of bilateral spreader grafts (SG). Imaging data were then converted into 3D models of the nasal airway. CT- and aOCT-generated models were compared by both static volumetric analysis and computational fluid dynamics (CFD) to ...

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    20. Salicylate-induced changes in organ of Corti vibrations

      Salicylate-induced changes in organ of Corti vibrations

      Intra organ of Corti (OC) vibrations differ from those measured at the basilar membrane (BM), with higher amplitudes and a wide-band nonlinearity extending well below a region’s best frequency. The vibrations are boosted by the cochlear amplifier, the active processes within the mammalian hearing organ, and are thus sensitive to metabolic or pharmacological manipulation. We introduced salicylate, a known blocker of outer hair cell (OHC) based electromotility, into the perilymphatic space by applying sodium salicylate onto the round window membrane. Vibration patterns of an area of the OC were mapped with phase sensitive optical coherence tomography before and after ...

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    21. Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

      Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

      After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1 week after noise exposure to determine if they ...

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    22. Study shows loud noises cause fluid buildup in the ear and suggests simple cure for noise-induced hearing loss

      Study shows loud noises cause fluid buildup in the ear and suggests simple cure for noise-induced hearing loss

      Exposure to loud noise, such as a firecracker or an ear-splitting concert, is the most common preventable cause of hearing loss. Research suggests that 12% or more of the world population is at risk for noise-induced loss of hearing. Loud sounds can cause a loss of auditory nerve cells in the inner ear, which are responsible for sending acoustic information to the brain, resulting in hearing difficulty. However, the mechanism behind this hearing loss is not fully understood.

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    23. Optical Coherence Tomography of the Middle Ear Using Ossiview

      Optical Coherence Tomography of the Middle Ear Using Ossiview

      The aim of this study is to understand the diagnostic applications for this imaging technology and identify particular disorders to target for future clinical investigations. Images obtained with the Ossiview device will be correlated to other standard of care (SoC) testing including microscopic otoscopy, CT scans, MRIs, audiologic testing results, and surgical and pathology reports.

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    1-24 of 424 1 2 3 4 ... 16 17 18 »
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