Otolaryngology -Optical Coherence Tomography News

Articles in category: Otolaryngology

1-24 of 153 1 2 3 4 5 6 7 »
1. Real-Time Subglottic Stenosis Imaging Using Optical Coherence Tomography in the Rabbit
  
  Explore JAMA Network May 19 2013 Otolaryngology
  
  Importance Subglottic stenosis (SGS) is a severe, acquired, potentially life-threatening disease that can be caused by endotracheal tube intubation. Newborns and neonates are particularly susceptible to SGS owing to the small caliber of their airway. Objective To demonstrate optical coherence tomography (OCT) capabilities in detecting injury and scar formation using a rabbit model. Optical coherence tomography may provide a noninvasive, bedside or intensive care unit modality for the identification of early airway trauma with the intention of preventing progression to SGS and can image the upper airway through an existing endotracheal tube coupled with a small fiber-optic probe. Design Rabbits ...
  Read Full Article
  
  Comment
  
  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
2. Full-Field Thickness Distribution of Human Tympanic Membrane Obtained with Optical Coherence Tomography
  
  Explore Home - Springer May 16 2013 Otolaryngology
  
  The full-field thickness distribution, three-dimensional surface model and general morphological data of six human tympanic membranes are presented. Cross-sectional images were taken perpendicular through the membranes using a high-resolution optical coherence tomography setup. Five normal membranes and one membrane containing a pathological site are included in this study. The thickness varies strongly across each membrane, and a great deal of inter-specimen variability can be seen in the measurement results, though all membranes show similar features in their respective relative thickness distributions. Mean thickness values across the pars tensa ranged between 79 and 97 μm; all membranes were thinnest in the ...
  Read Full Article
  
  Comment
  
  Mentions: Adrian G. Podoleanu University of Kent Adrian Bradu
3. Clinical optical coherence tomography in head and neck oncology: overview and outlook
  
  Explore OA Publishing Apr 26 2013 Otolaryngology
  
  Objective Optical coherence tomography is a high-resolution and minimally invasive optical imaging method, which provides in vivo cross-sectional images of living tissue in real-time. Our intention is to present a contemporary and comprehensive review on the role of optical coherence tomography in head and neck oncology. Recent fi ndings Promising results have been published in small, single-centre studies applying optical coherence tomography in clinical settings for the diagnostic workup of superficial pathologies of the upper aerodigestive tract, showing that it can be a helpful adjunct to standard white light endoscopy. Using optical coherence tomography, microanatomical structures of healthy and diseased ...
  Read Full Article
  
  Comment
  
  Mentions: Imalux Imalux Niris Marc Rubinstein
4. Intra-operative application of confocal endomicroscopy using a rigid endoscope
  
  Explore Cambridge Journals Online Apr 26 2013 Otolaryngology
  
  Objective: To introduce the application of confocal endomicroscopy during microlaryngoscopy, to enable intra-operative evaluation of human laryngeal epithelium. Methods: A rigid endoscope was connected to the scanner head of a Heidelberg Retina Tomograph II confocal laser scanning system via an adapter. The endoscope was gently placed on the surface of a vocal fold through a laryngoscope during microlaryngoscopy. Results: The application of confocal endomicroscopy using a rigid endoscope enabled technical improvements (i.e. improved image quality, automatic volume scan, and reduced tissue pressure due to the presence of a perforation plate with central hole at the end of the endoscope ...
  Read Full Article
  
  Comment
  
  Mentions: Universität Rostock
5. Investigation of bacterial biofilm in the human middle ear using optical coherence tomography and acoustic measurements
  
  Explore ScienceDirect Apr 15 2013 Otolaryngology
  
  Children with chronic otitis media (OM) often have conductive hearing loss which results in communication difficulties and requires surgical treatment. Recent studies have provided clinical evidence that there is a one-to-one correspondence between chronic OM and the presence of a bacterial biofilm behind the tympanic membrane (TM). Here we investigate the acoustic effects of bacterial biofilms, confirmed using optical coherence tomography (OCT), in adult ears. Non-invasive OCT images are collected to visualize the cross-sectional structure of the middle ear, verifying the presence of a biofilm behind the TM. Wideband measurements of acoustic reflectance and impedance (0.2 to 6 [kHz ...
  Read Full Article
  
  Comment
  
  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Cac T. Nguyen
6. Physical Optics Corporation Receives 2013 NIH Grant for Ear Canal Optical Coherence Tomography System
  
  Explore Optical Coherence Tomography News Apr 12 2013 Otolaryngology , Funding
  
  Physical Optics Corporation Receives 2013 NIH Grant for $682,804 for Ear Canal Optical Coherence Tomography System. The principal investigator is Paul Shnitser. The program is part of a multiyear program that started in 2010 and ends in 2014. Below is a summary of the work. The National Institute on Deafness and Other Communication Disorders (NIDCD) supports research and development of innovative technologies for improving the quality and use of hearing aid devices. Physical Optics Corporation (POC) proposes the development of a new Ear Canal Optical Coherent Tomography (ECOCT) system to obtain the shape of the individual ear canal and ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health Physical Optics Corporation
7. OCT Medical Imaging Incorporated receives NIH Grant for Development of a 3D Real-Time Imaging System for Subglottic Stenosis
  
  Explore Optical Coherence Tomography News Apr 2 2013 Otolaryngology , Funding
  
  OCT Medical Imaging Incorporated received a $308,509 2013 NIH grant for Development of a 3D Real-Time Imaging System for Subglottic Stenosis. The principal investigator is Tirunelveli Ramalingam. The program is part of a multi-year program that started in 2012 and ends in 2014. Below is a summary of the work. Major common cause of subglotis is endotracheal intubation during the critical first days of life. In the premature infant and newborn patient, thi condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Further, the tissues of the subglottis are delicate in nature, easily ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health OCT Medical Imaging Inc Ram Ramalingam
8. Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea
  
  Explore Conference Proceedings Apr 1 2013 Otolaryngology
  
  Most of the optical coherence tomographic (OCT) systems for high resolution imaging of biological specimens are based on refractive type microscope objectives, which are optimized for specific wave length of the optical source. In this study, we present the feasibility of using commercially available reflective type objective for high sensitive and high resolution structural and functional imaging of cochlear microstructures of an excised guinea pig through intact temporal bone. Unlike conventional refractive type microscopic objective, reflective objective are free from chromatic aberrations due to their all-reflecting nature and can support a broadband of spectrum with very high light collection efficiency.
  Read Full Article
  
  Comment
  
  Mentions: Oregon Health & Science University University of Washington Ruikang K. Wang
9. Sensing and three-dimensional imaging of cochlea and surrounding temporal bone using swept source high-speed optical coherence tomography
  
  Explore Conference Proceedings Apr 1 2013 Otolaryngology
  
  We describe a novel dual-functional optical coherence tomography (OCT) system with both a fiber probe using a sapphire ball lens for cross-sectional imaging and sensing, and a 3-D bulk scanner for 3-D OCT imaging. A theoretical sensitivity model for Common Path (CP)-OCT was proposed to assess its optimal performance based on an unbalanced photodetector configuration. A probe design with working distances (WD) 415μm and lateral resolution 11 μm was implemented with sensitivity up to 88dB. To achieve high-speed data processing and real-time three-dimensional visualization, we use graphics processing unit (GPU) based real-time signal processing and visualization to boost ...
  Read Full Article
  
  Comment
  
  Mentions: Johns Hopkins University Jin U. Kang Mingtao Zhao
10. Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing
  
  Explore Optical Coherence Tomography News Mar 16 2013 Otolaryngology
  
  The Oregon Hearing Research Centre (OHRC) at the Oregon Health and Science University (OHSU), Portland, Oregon is one of the strongest hearing research groups in the world, and one of the early adopters of optical coherence tomography technology in the field of hearing research. Researchers at OHRC have developed a couple of novel OCT based imaging technologies for functional imaging of middle and inner ear. This includes high-speed OCT system for in vivo imaging of microstructural morphology and micvascular perfusion within the cochlea [1,2], phase-sensitive time-domain and Fourier domain OCT for studying cochlear micromechanics [3,4] and middle ear ...
  Read Full Article
  
  Comment
  
  Mentions: Oregon Health & Science University University of Washington Ruikang K. Wang
11. Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography
  
  Explore Conference Proceedings Mar 12 2013 Otolaryngology
  
  A major reason we can perceive faint sounds and communicate in noisy environments is that the outer hair cells of the organ of Corti enhance the sound-evoked motions inside the cochlea. To understand how the organ of Corti works, we have built and tested the phase-sensitive Fourier domain optical coherence tomography (PSFDOCT) system. This system has key advantages over our previous time domain OCT system [1]. The PSFDOCT system has better signal to noise and simultaneously acquires vibration data from all points along the optical-axis [2]. Feasibility of this system to measure in vitro cochlear vibrations in the apex was ...
  Read Full Article
  
  Comment
  
  Mentions: Oregon Health & Science University Ruikang K. Wang Steven L. Jacques
12. Method And Apparatus For Examining Inner Ear
  
  Explore patentscope.wipo.int Mar 8 2013 Otolaryngology , Patents
  
  An apparatus, for examining an inner ear is provided. An endoscope is provided, comprising a wave guide and an end piece comprising an end window to be placed a first distance from an inner ear, wherein the waveguide focuses light to create a focal plane the first distance from the end window. An optical coherence tomography (OCT) system is connected to a second end of the wave guide and comprises an imaging system connected to the OCT system for generating an image of the inner ear.
  Read Full Article
  
  Comment
  
  Mentions: Texas A&M University Brian E. Applegate
13. Quantitative polarized light microscopy of unstained mammalian cochlear sections
  
  Explore SPIE | Journal Feb 15 2013 Microscopy , Otolaryngology
  
  Hearing loss is the most common sensory deficit in the world, and most frequently it originates in the inner ear. Yet, the inner ear has been difficult to access for diagnosis because of its small size, delicate nature, complex three-dimensional anatomy, and encasement in the densest bone in the body. Evolving optical methods are promising to afford cellular diagnosis of pathologic changes in the inner ear. To appropriately interpret results from these emerging technologies, it is important to characterize optical properties of cochlear tissues. Here, we focus on that characterization using quantitative polarized light microscopy (qPLM) applied to unstained cochlear ...
  Read Full Article
  
  Comment
  
  Mentions: Massachusetts Institute of Technology Harvard University Massachusetts Eye and Ear Infirmary
14. In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography
  
  Explore opticsinfobase.org Jan 15 2013 Otolaryngology
  
  Sound transduction within the auditory portion of the inner ear, the cochlea, is a complex nonlinear process. The study of cochlear mechanics in large rodents has provided important insights into cochlear function. However, technological and experimental limitations have restricted studies in mice due to their smaller cochlea. These challenges are important to overcome because of the wide variety of transgenic mouse strains with hearing loss mutations that are available for study. To accomplish this goal, we used spectral domain optical coherence tomography to visualize and measure sound-induced vibrations of intracochlear tissues. We present, to our knowledge, the first vibration measurements ...
  Read Full Article
  
  Comment
  
  Mentions: Stanford University Texas A&M University Rice University
15. Assessing eardrum deformation by digital holography
  
  Explore Home: SPIE.org Jan 9 2013 Otolaryngology
  
  A novel system measures the structure, shape, and acoustically induced changes to the membrane of the human middle ear, to help diagnose and treat hearing disorders.
  
  Understanding the human hearing process and associated disorders depends on quantifying the geometry and properties of the outer, middle, and inner ear. The eardrum, also known as the tympanic membrane (TM), transforms sound waves from the outer ear into vibrations of the middle ear. Because of the TM's important role, and its direct visibility through the ear canal, current ear exams assess a patient's hearing by considering the health of the eardrum ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health Harvard University Massachusetts Eye and Ear Infirmary
16. Investigation of the human tympanic membrane oscillation ex vivo by Doppler optical coherence tomography
  
  Explore Wiley Online Library Dec 10 2012 Otolaryngology , Doppler
  
  Investigations of the tympanic membrane (TM) can have an important impact on understanding the sound conduction in the ear and can therefore support the diagnosis and treatment of diseases in the middle ear. High-speed Doppler optical coherence tomography (OCT) has the potential to describe the oscillatory behaviour of the TM surface in a phase-sensitive manner and additionally allows acquiring a three-dimensional image of the underlying structure. With repeated sound stimuli from 0.4 kHz to 6.4 kHz, the whole TM can be set in vibration and the spatially resolved frequency response functions (FRFs) of the tympanic membrane can be ...
  Read Full Article
  
  Comment
  
  Mentions: Dresden University of Technology Edmund Koch Lars Kirsten
17. Dual instrument for in vivo and ex vivo OCT imaging in an ENT department
  
  Explore opticsinfobase.org Dec 4 2012 Dermatology , Otolaryngology
  
  A dual instrument is assembled to investigate the usefulness of optical coherence tomography (OCT) imaging in an ear, nose and throat (ENT) department. Instrument 1 is dedicated to in vivo laryngeal investigation, based on an endoscope probe head assembled by compounding a miniature transversal flying spot scanning probe with a commercial fiber bundle endoscope. This dual probe head is used to implement a dual channel nasolaryngeal endoscopy-OCT system. The two probe heads are used to provide simultaneously OCT cross section images and en face fiber bundle endoscopic images. Instrument 2 is dedicated to either in vivo imaging of accessible surface ...
  Read Full Article
  
  Comment
  
  Mentions: George M. Dobre Adrian G. Podoleanu University of Kent
18. Quantitative Distinction of Unique Vocal Fold Subepithelial Architectures Using Optical Coherence Tomography
  
  Explore annals.com Dec 1 2012 Otolaryngology
  
  Objectives : The primary objective of this study was to quantitatively analyze ex vivo porcine, fetal human, and adult human vocal folds by use of optical coherence tomography (OCT). A secondary objective was to quantitatively discriminate among 1-, 2-, and 3-layer lamina propria structures. Methods : We performed an analysis of the vocal folds of 10 adult pig, 3 adult human, and 2 fetal human vocal fold specimens using OCT and histologic techniques. We present a quantitative comparison of the OCT results and histologic findings. Results : We found that OCT allowed for the visualization of the subepithelial vocal fold architecture of all ...
  Read Full Article
  
  Comment
  
  Mentions: Harvard University Massachusetts Eye and Ear Infirmary Caroline Boudoux
19. The new age of laryngeal imaging
  
  Explore LWW Online Dec 1 2012 Otolaryngology
  
  The vocal folds are the key to understand phonation. Their complex anatomical architecture is critical to phonatory function and to disorders that occur in the glottis. The architectural arrangement of the vocal folds enables the intricate biomechanical action of the folds and it is this arrangement that we strive to reconstitute in our efforts to treat dysphonia. The combined three-dimensional vibratory wave, the differing shear properties at tissue interfaces and the elastic recoil provided by the vocal ligament all contribute to vocal power and quality. Although scientists at Bell Laboratories, USA developed high-speed cameras capable of capturing 5000 sfps in ...
  Read Full Article
  
  Comment
  
  Mentions: University of Auckland
20. Vocal fold composition and early glottic carcinoma infiltration
  
  Explore Home - Springer Nov 19 2012 Oncology , Otolaryngology
  
  Background Current imaging techniques provide only limited information pertaining to the extent of infiltration of laryngeal carcinomas into vocal fold tissue layers. Therefore, it is needed to seek the contribute to the body of knowledge surrounding examination and characterization in laryngeal carcinoma infiltration. Methods Excised larynges were collected from 30 male laryngectomy patients with an average age of 43.5 years (ranging 36 to 55 years) and history of smoking (≥10 years) exhibiting T1, T2, or subglottal (normal vocal fold) carcinomas. Vocal folds were preserved via freezing or immersion in paraffin. The depth of the mucosa, submucosa, and muscular layers ...
  Read Full Article
  
  Comment
21. Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract
  
  Explore Wiley Online Library Oct 31 2012 Otolaryngology
  
  Background This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT). Methods An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary lesions were rated via OCT concerning invasiveness by an “unblinded” investigator, then biopsied, and the results correlated. All OCT images were evaluated by 3 “blinded” investigators. Forty-eight images underwent retrospective image analysis. Results Screening showed large differences concerning epithelial thicknesses, but good correlation (κ = 0.63) between OCT and histopathological slides. In the ...
  Read Full Article
  
  Comment
  
  Mentions: Herbert Stepp
22. System and method for designing an ear insert device
  
  Explore uspto.gov Oct 9 2012 Otolaryngology , Patents
  
  A method for designing an ear insert device using anatomical information relating to the ear. A user record is that includes anatomical information relating to an ear of a user is received. The anatomical information comprises at least one sub-dermal feature of an ear canal. The user record is processed to obtain an ear insert device design record. The ear insert device design record comprises a three dimensional representation of a bounding surface shape having surface boundaries that substantially conform to surface boundaries of the ear canal and the at least one sub-dermal feature of the ear canal. An ear ...
  Read Full Article
  
  Comment
23. Mapping the Histology of the Human Tympanic Membrane by Spatial Domain Optical Coherence Tomography
  
  Explore SpringerLink Home Sep 6 2012 Otolaryngology
  
  The tympanic membrane is one of the major structures of the ear that aids in the hearing process, giving humans one of the five major senses. It is hypothesized that sound induced displacements of the membrane, which allow humans to hear, are directly related to the membrane’s medial layer which is comprised of a network of collagen fibers. Limitations in available medical imaging techniques have thus far inhibited the further study of these fibers. In this paper we detail an imaging system that we developed with the capability to quantitatively and noninvasively image the internal structures of biological tissues ...
  Read Full Article
  
  Comment
  
  Mentions: Massachusetts Eye and Ear Infirmary
24. Optical coherence tomography: imaging the larynx
  
  Explore LWW Online Aug 25 2012 Otolaryngology
  
  Purpose of review: Using optical coherence tomography (OCT) to image the larynx during diagnosis and treatment of a vast array of laryngeal disorders continues to develop along with innovative surgical techniques. Precise delineation of vocal fold-layered microstructure allows for better understanding of the impact of benign and malignant lesions on laryngeal function, and optical coherence is uniquely suited to provide detail of the interface between these lesions and adjacent normal tissue. This review provides the reader with a timely update on current clinical and research applications of OCT. Recent findings: Recent advances in OCT include adaptation of these modalities to ...
  Read Full Article
  
  Comment
  
  Mentions: Massachusetts General Hospital Harvard University
1-24 of 153 1 2 3 4 5 6 7 »