Gynecology -Optical Coherence Tomography News

Articles in category: Gynecology

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1. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography
  
  Explore AME Publishing Company Feb 21 2015 Gynecology
  
  Background: Endocervical mucus acts as an important barrier to block human immunodeficiency virus (HIV) infection and other sexually transmitted diseases (STDs). Disruption of the mucus layer increases the risk of infection for females. An effective method to image the mucus properties can serve as a pre-screening step to risk-stratify the susceptible population. Methods: We proposed to use optical coherence tomography (OCT) to quantitatively measure the thickness of endocervical mucus. We used a home-built bench-top OCT system to monitor the dynamic change in mucus thickness of a cultivated sample. We also fabricated a prototype endoscopic OCT probe to demonstrate potential in ...
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  Mentions: Northwestern University Ji Yi Hao F. Zhang
2. Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer
  
  Explore Conference Proceedings Jan 1 2015 Gynecology , Oncology
  
  The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six ...
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  Mentions: Jennifer K. Barton University of Arizona Urs Utzinger
3. Effect of optical clearing agents on optical coherence tomography images of cervical epithelium
  
  Explore Home - Springer Dec 13 2014 Gynecology
  
  Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in order to detect precancerous and cancerous cervical lesions. Optical clearing agents (OCAs) temporarily reduce the optical scattering of biological tissues. The purpose of this study was to investigate their influence on OCT imaging. OCT images were taken from unsuspicious and suspicious areas of fresh conization specimens immediately after resection and 5, 10, and 20 min after application of dimethyl sulfoxide ( DMSO ) or polyethylene glycol (PEG). Corresponding histologies were obtained from all sites. The images taken 5, 10, and 20 min after application of OCA were compared to ...
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  Mentions: Herbert Stepp Ludwig Maximilian University of Munich Julia Gallwas
4. An automated 3D registration method for optical coherence tomography volumes
  
  Explore IEEE Xplore Nov 9 2014 Gynecology
  
  Optical coherence tomography (OCT) is able to provide high resolution volumetric data for biological tissues. However, the field of view (FOV) of OCT is sometimes smaller than the field of interest, which limits the clinical application of OCT. One way to overcome the drawback is to stitch multiple 3D volumes. In this paper, we propose a novel method to register multiple overlapped volumetric OCT data into a single volume. The relative positions of overlapped volumes were estimated on en face plane and at depth. On en face plane, scale invariant feature transform (SIFT) was implemented to extract the keypoints in ...
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  Mentions: Columbia University Christine P. Fleming Hendon
5. The Value of Optical Coherence Tomography in Determining Surgical Margins in Squamous Cell Carcinoma of the Vulva: A Single-Center Prospective Study.
  
  Explore LWW Online Oct 31 2014 Gynecology , Oncology
  
  Background: Vulvar squamous cell carcinoma (VSCC) is treated with wide local excision. The challenge is to remove as much skin as necessary to prevent recurrence, but meanwhile preserve genital skin to diminish morbidity. Optical coherence tomography (OCT) is a noninvasive imaging tool that produces cross-sectional images. Optical coherence tomography could be helpful in determining appropriate surgical margins during excision of VSCC. Objective: This study aimed to assess the value of OCT in determining appropriate surgical margins in patients operated for VSCC. We hypothesize that benign tissue will differ qualitatively (presence of clear epidermal layers) and quantitatively (epidermal layer thickness and ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
6. An overview of optical coherence tomography for ovarian tissue imaging and characterization
  
  Explore Wiley Online Library Oct 22 2014 Gynecology
  
  Ovarian cancer has the lowest survival rate among all the gynecologic cancers because it is predominantly diagnosed at late stages due to the lack of reliable symptoms and efficacious screening techniques. Optical coherence tomography (OCT) is an emerging technique that provides high-resolution images of biological tissue in real time, and demonstrates great potential for imaging of ovarian tissue. In this article, we review OCT studies for visualization and diagnosis of human ovaries as well as quantitative extraction of ovarian tissue optical properties for classifying normal and malignant ovaries. OCT combined with other imaging modalities to further improve ovarian tissue diagnosis ...
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  Mentions: National Institutes of Health Quing Zhu Molly Brewer
7. Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy
  
  Explore SPIE | Journal Jul 23 2014 Gynecology , Oncology
  
  Ovarian cancer is particularly deadly because it is usually diagnosed after it has metastasized. We have previously identified features of ovarian cancer using optical coherence tomography (OCT) and second-harmonic generation (SHG) microscopy (targeting collagen). OCT provides an image of the ovarian microstructure, while SHG provides a high-resolution map of collagen fiber bundle arrangement. Here, we investigated the diagnostic potential of dual-modality OCT and SHG imaging. We conducted a fully crossed, multireader, multicase study using seven human observers. Each observer classified 44 ex vivo mouse ovaries (16 normal and 28 abnormal) as normal or abnormal from OCT, SHG, and simultaneously viewed ...
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  Mentions: Jennifer K. Barton University of Arizona Photini F. S. Rice
8. The handheld smartphone device which could spot cancer
  
  Explore BBC - Homepage Jun 9 2014 Gynecology , Oncology
  
  A £240 ($400) handheld device which can analyse potential tumours is being developed in Tel Aviv. The Mobile OCT device consists of a smartphone to take the images, a lens, some lights and a plastic handle. The images are assessed by the device's operator and are then uploaded for review by a professional. BBC Click's Spencer Kelly reports.
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  Mentions: MobileOCT Ariel Beery
9. MobileOCT uses a 3D printed case to turn smartphones into cancer screening devices
  
  Explore Optical Coherence Tomography News Jun 9 2014 Gynecology , Oncology
  
  There are plenty of nifty smartphone accessories out there today, but how many of them can potentially save lives? MobileOCT is one of the latest startups to raise their hand to that question. The self-described “point-of-care diagnostics company” based in Tel Aviv, Israel, has developed a 3D printed smartphone accessory that leverages a mobile phone’s camera to detect cancer. MobileOCT (pronounced “Mobile Oh-See-Tee” – the “OCT” stands for optical coherence tomography) is starting out by pushing its mobile colposcope, which is a magnifying device used to take images of the vagina or cervix. The company’s first target is cervical ...
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  Mentions: MobileOCT Ariel Beery
10. Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)
  
  Explore DigitalCommons@UConn Jun 5 2014 Gynecology , Oncology , Student Theses
  
  Ovarian cancer is the fifth most common cancer among women and has the highest mortality rate of all gynecologic cancers. Current clinical imaging modalities are limited by poor sensitivity and specificity. Therefore, there is an urgent need to develop effective tools to detect ovarian cancer. In this dissertation, two imaging modalities, optical coherence tomography (OCT) and photoacoustic imaging have been investigated for ovarian cancer detection and characterization. In the first modality, optical scattering coefficient, phase retardation and phase retardation rate were quantitatively extracted from polarization-sensitive OCT (PS-OCT) images. A highly positive correlation was found between those three parameters and collagen ...
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  Mentions: Quing Zhu Molly Brewer University of Connecticut
11. Epithelial stem cells as mucosal antigen-delivering cells: a novel preventive approach
  
  Explore BioMed Central May 27 2014 Gynecology
  
  Introduction HIV transmission occurs predominantly across mucosal surfaces. An ideal preventive strategy would be to target HIV at mucosal entry sites to prevent infection. We developed a novel epithelial stem cells-based AIDS preventive approach in female macaques. This approach is based on the ability of therapeutic lentiviral vectors integrated in mucosal epithelial stem cells to induce virus-specific cellular immune responses at mucosal sites of viral entry. We first intended to expose the cervicovaginal tract to conditions used for intravaginal vaccine delivery and non-invasively image local tissues to determine the vaccination effects on epithelial integrity and generation of antigen-specific mucosal immune ...
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12. Effect of acetic acid on optical coherence tomography (OCT) images of cervical epithelium
  
  Explore Home - Springer May 16 2014 Gynecology
  
  Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in the identification of precancerous and cancerous cervical lesions. The purpose of this study was to investigate the effect of acetic acid on OCT imaging. OCT images were taken from unsuspicious and suspicious areas of fresh conization specimens immediately after resection and 3 and 10 min after application of 6 % acetic acid. A corresponding histology was obtained from all sites. The images taken 3 and 10 min after application of acetic acid were compared to the initial images with respect to changes in brightness, contrast, and scanning depth ...
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  Mentions: Herbert Stepp Ludwig Maximilian University of Munich Julia Gallwas
13. Clinical applications of functional optical coherence tomography (Thesis)
  
  Explore UvA DARE Mar 19 2014 Gynecology , Urology , Student Theses
  
  The purpose of the work presented in this thesis is to show the potential of functional optical coherence tomography (OCT) to discriminate pathological from normal tissues in several clinical settings, by means of the attenuation coefficient. To that end, several fundamental studies were carried out to increase the fundamental understanding of the measured signals (in phantoms, during apoptosis) and both ex and in vivo investigations are performed in the urological and gynecological clinic.
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  Mentions: Dirk J. Faber Frank D. Verbraak Ton G. van Leeuwen
14. Novel Advancements in Colposcopy: Historical Perspectives and a Systematic Review of Future Developments
  
  Explore LWW Online Mar 19 2014 Gynecology
  
  Objective: To describe novel innovations and techniques for the detection of high-grade dysplasia. Materials and Methods: Studies were identified through the PubMed database, spanning the last 10 years. The key words (["computerized colposcopy" or "digital colposcopy" or "spectroscopy" or "multispectral digital colposcopy" or "dynamic spectral imaging", or "electrical impedance spectroscopy" or "confocal endomicroscopy" or "confocal microscopy"or "optical coherence tomography"] and ["cervical dysplasia" or cervical precancer" or "cervix" or "cervical"]) were used. The inclusion criteria were published articles of original research referring to noncolposcopic evaluation of the cervix for the detection of cervical dysplasia. Only English-language articles from the past ...
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15. Picturing Cervical Cancer
  
  Explore clinchem.org Dec 31 2013 Gynecology , Oncology
  
  The Pap smear has been used to test women for cervical cancer since its invention in 1928. With a simple swipe and smear, doctors have been able to use microscopic observation to detect cancerous activity. Because cervical cancer is one of the most preventable forms of cancer, the Pap smear revolutionized how we deal with the disease. Yet, worldwide, 275 000 women ( 1 ) still die from cervical cancer each year. That's because although the Pap is an efficient test, it requires elements such as facilities, follow-up visits, and trained cytology technicians, making it difficult to use in low- to ...
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  Mentions: David Levitz MobileOCT
16. Feature Of The Week 7/7/13: Visualization of Synthetic Mesh In Vaginal Walls Using OCT
  
  Explore Optical Coherence Tomography News Jul 7 2013 Gynecology
  
  Owing to the recent upsurge in adverse events reported after mesh-augmented pelvic organ prolapse (POP) repairs, our aim was to determine whether the location and depth of synthetic mesh can be measured postoperatively within the vaginal tissue microstructure using optical coherence tomography (OCT ). Seventeen patients with prior mesh-augmented repairs were recruited for participation. Patients were included if they had undergone an abdominal sacral colpopexy (ASC) or vaginal repair with mesh. Exclusion criteria were a postoperative period of <6 months, or the finding of mesh exposure on examination. OCT was used to image the vaginal wall at various POP-Q sites. If ...
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  Mentions: Imalux Imalux Niris Dara F. Shalom
17. Examination of Diagnostic Features in Multiphoton Microscopy and Optical Coherence Tomography Images of Ovarian Tumorigenesis in a Mouse Model (Thesis)
  
  Explore arizona.openrepository.com Jun 11 2013 Gynecology , Oncology , Student Theses
  
  Ovarian cancer is a deadly disease owing to the non-specific symptoms and suspected rapid progression, leading to frequent late stage detection and poor prognosis. Medical imaging methods such as CT, MRI and ultrasound as well as serum testing for cancer markers have had extremely poor performance for early disease detection. Due to the poor performance of available screening methods, and the impracticality and ineffectiveness of taking tissue biopsies from the ovary, women at high risk for developing ovarian cancer are often advised to undergo prophylactic salpingo-oophorectomy. This surgery results in many side effects and is most often unnecessary since only ...
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  Mentions: University of Arizona
18. University of Arizona Receives NIH Grant for Diagnosis of Ovarian Cancer by Confocal Microendoscopy.
  
  Explore Optical Coherence Tomography News May 11 2013 Gynecology , Oncology , Funding
  
  University of Arizona Received a 2013 NIH Grant for $65,063 for Diagnosis of Ovarian Cancer by Confocal Microendoscopy. The principal investigator is Arthur Gmitro. The program started in 2005 and ends in 2014. Below is a summary of the proposed work. The objective of this research is to further develop and clinically validate a real-time multispectral confocal microendoscope for in vivo diagnosis of ovarian cancer. The confocal microendoscope is a new type of instrument for visualizing tissue at the cellular level and has shown great promise for performing optical biopsy. Confocal microendoscopy has the potential to provide a physician ...
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  Mentions: National Institutes of Health University of Arizona
19. Visualization of synthetic mesh utilizing optical coherence tomography
  
  Explore Home - Springer May 4 2013 Gynecology , Urology
  
  Introduction and hypothesis Owing to the recent upsurge in adverse events reported after mesh-augmented pelvic organ prolapse (POP) repairs, our aim was to determine whether the location and depth of synthetic mesh can be measured postoperatively within the vaginal tissue microstructure using optical coherence tomography (OCT). Methods Seventeen patients with prior mesh-augmented repairs were recruited for participation. Patients were included if they had undergone an abdominal sacral colpopexy (ASC) or vaginal repair with mesh. Exclusion criteria were a postoperative period of <6 months, or the finding of mesh exposure on examination. OCT was used to image the vaginal wall at ...
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  Mentions: Imalux Dara F. Shalom
20. Duke University Receives NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health
  
  Explore Optical Coherence Tomography News Apr 26 2013 Gynecology , Funding
  
  Duke University Received a 2013 NIH Grant for $410,399 for Novel Determination of Microbicide PK in Women's Reproductive Health. The principal investigator is David Katz. The program started in 2012 and ends in 2016. Below is a summary of the proposed work. Vaginal microbicides offer much promise to prevent sexual transmission of HIV. The pharmacokinetics (PK) of a product (active pharmaceutical ingredient + dosage form) is central to prophylactic functionality (PD). But our ability to measure and predict microbicide PK is currently limited. Further, microbicide PD depends on how product + dosage regimen accommodate a range of conditions of the ...
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  Mentions: National Institutes of Health Duke University
21. In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
  
  Explore Conference Proceedings Apr 1 2013 Gynecology , Oncology
  
  Our goal is to use optical coherence tomography (OCT) and multiphoton microscopy (MPM) to detect early tumor development in a mouse model of ovarian neoplasia. We hope to use information regarding early tumor development to create a diagnostic test for high-risk patients. In this study we collect in vivo images using OCT, second harmonic generation and two-photon excited fluorescence from non-vinylcyclohexene diepoxide (VCD)-dosed and VCD-dosed mice. VCD causes follicular apoptosis (simulating menopause) and leads to tumor development. Using OCT and MPM we visualized the ovarian microstructure and were able to see differences between non-VCD-dosed and VCD-dosed animals. This leads ...
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  Mentions: Jennifer K. Barton University of Arizona Robert R. Alfano
22. Feature Of The Week 2/3/13: Automated Segmentation Algorithm for Medical Image Processing using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Feb 1 2013 Gynecology , Urology
  
  Optical coherence tomography (OCT) is a noninvasive optical imaging technique for in vivo and in situ imaging of microstructure in biological tissues. Improvements in identification, imaging, and visualization of biological microstructures are necessary before OCT clinical use. Using the proposed algorithm, OCT images of the prostate and cervicovaginal epithelium were segmented to differentiate the cavernous nerves from the prostate gland and to detect minute changes in the epithelial layer, respectively. To detect these nerves and epithelial layer changes, three image features were employed: Gabor filter, Daubechies wavelet, and Laws filter. The Gabor feature was applied with different standard deviations in ...
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  Mentions: Johns Hopkins University Imalux Massoud Motamedi
23. Monitoring Vaginal Epithelial Thickness Changes Noninvasively in Sheep Using Optical Coherence Tomography
  
  Explore ajog.org Jan 27 2013 Gynecology
  
  Objective High-resolution optical coherence tomography (OCT), can be used noninvasively to evaluate vaginal morphologic features, including epithelial thickness, to assess this protective barrier in transmission of sexually transmitted infections and to monitor tissue response to topical medications and hormonal fluctuations. We examined the utility of OCT to measure epithelial thickness noninvasively before and after topical treatment with a drug that causes epithelial thinning. Study Design Twelve female sheep were treated with intravaginal placebo (n=4) or nonoxynol-9 (n=8). Vaginal OCT images were obtained before and 24 hours after treatment. Four sheep in the nonoxynol-9 group were also examined on ...
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  Mentions: Massoud Motamedi University of Texas Medical Branch
24. Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia
  
  Explore LWW Online Jan 27 2013 Gynecology , Oncology
  
  Objective: The study aimed to determine if the difference in cervical epithelium brightness, as measured by optical coherence tomography (OCT), has potential as a distinguishing characteristic of normal, low-grade, high-grade (cervical intraepithelial neoplasia 2+), and cancer histological findings. Materials and Methods: Information from 476 women was available for analysis. Demographic information was collected through in-person interview. All participants were human papillomavirus positive and/or had abnormal cytological finding and underwent colposcopy or unaided visual inspection and examination by OCT by quadrant. All women had a minimum of 4 OCT-matched cervical biopsies and endocervical curettage. Two sample t tests were used ...
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  Mentions: Andrew M. Rollins Imalux Case Western Reserve University
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