1. Articles in category: Gynecology

    1-24 of 128 1 2 3 4 5 6 »

    1. Researchers pilot 'itty bitty' device for earlier ovarian cancer detection

      Explore Home | University of Arizona News Gynecology , Oncology
      Researchers pilot 'itty bitty' device for earlier ovarian cancer detection

      Due to a lack of effective screening and diagnostic tools, more than three-fourths of ovarian cancer cases are not found until the cancer is in an advanced stage. As a result, fewer than half of all women with ovarian cancer survive more than five years after diagnosis. Jennifer Barton , director of the University of Arizona BIO5 Institute and Thomas R. Brown Distinguished Chair in Biomedical Engineering , has spent years developing a device small enough to image the fallopian tubes – narrow ducts connecting the uterus to the ovaries – and search for signs of early-stage cancer. Dr. John Heusinkveld has now used ...

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      Mentions: FDA University of Arizona

    2. Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Explore Optical Coherence Tomography News Gynecology , Funding
      Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Glannaventa Receives a 2021 NIH NCI SBIR Grant for $399,331 for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. The principal investigator is John Black. Below is a summary of the proposed work. This year, over 22,000 women in the U.S. will be diagnosed with ovarian cancer (OvCa), and ~14,000 will die from this disease. Approximately 9,000 of these deaths occur from high-grade serous epithelial cancer (HGSC) primarily because of our inability to detect the disease in its early stages. OvCa accounts for 2.5% of all ...

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      Mentions: Glannaventa, Inc.

    3. University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      Explore Optical Coherence Tomography News Gynecology , Funding
      University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      University of California at Irvine Receives a 2021 NIH Grant for $1,946,945 for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Genitourinary Syndrome of Menopause (GSM) affects up to 50% of women and negatively affects their quality of life with regard to general health and sexual function. Hormone therapy is the most commonly performed procedure to supplement the natural estrogen, but health risk associated with long-term therapy exists. Recently, an alternative therapy has been proposed using fractional CO2 micro- ablation ...

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      Mentions: National Institutes of Health UC Irvine

    4. Endometrium optical coherence tomography (OCT) and histomorphometry in implantation window and their relationships with reproductive failure and implantation outcome

      Explore Journals Gynecology
      Endometrium optical coherence tomography (OCT) and histomorphometry in implantation window and their relationships with reproductive failure and implantation outcome

      Study question How do endometrium OCT image characteristics during peri-implantation window correlate with histomorphometry and associate with implantation outcomes in women with reproductive failure? Summary answer Endometrium OCT intensity correlated with stromal cell density and gland size. Endometrium with recurrent implantation failure had low OCT intensity but reversed in successful implantation. What is known already OCT is a non-invasive imaging technique using low energy near-infrared light to capture micrometer-scale resolution images from optical scattering media. An image produced by OCT resembles tissue architecture observed in histology, so OCT imaging has been regarded as “optical biopsy”. Our previous findings demonstrated OCT ...

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      Mentions: The Chinese University of Hong Kong University of Hong Kong

    5. Pelvic Organs Prolapse Treatment Using Neodymium Laser

      Explore Home - ClinicalTrials.gov Gynecology , Clinical Trials
      Pelvic Organs Prolapse Treatment Using Neodymium Laser

      The aim of this prospective study is investigation of efficiency and safety of medical device "Magic Max" for preoperative treatment of pelvic organs prolapse I-II degree of severity. To assess the condition of the vaginal walls and vulva before and after laser treatment, the following methods will be used: ultrasonography with Doppler ultrasonography, vaginal health index, histological examination, immunohistochemical examination, optical coherence tomography (OCT) (elastography). Pelvic Floor Distress Inventory Questionnaire (PFDI-20), The Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF), Pelvic Floor Impact Questionnaire (PFIQ-7) will be used to collect feedback on ...

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    6. Multidimensional Data Processing for Optical Coherence Tomography Imaging (Thesis)

      Explore ProQuest Gynecology , Student Theses
      Multidimensional Data Processing for Optical Coherence Tomography Imaging (Thesis)

      Optical Coherence Tomography (OCT) is a medical imaging technique which distinguishes itself by acquiring microscopic resolution images in-vivo at millimeter scale fields of view. The resulting in images are not only high-resolution, but often multi-dimensional to capture 3-D biological structures or temporal processes. The nature of multi-dimensional data presents a unique set of challenges to the OCT user that include acquiring, storing, and handling very large datasets, visualizing and understanding the data, and processing and analyzing the data. In this dissertation, three of these challenges are explored in depth: sub-resolution temporal analysis, 3-D modeling of fiber structures, and compressed sensing ...

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      Mentions: Columbia University

    7. In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

      Explore Cell Developmental Biology , Gynecology
      In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

      Developmental biologists have always relied on imaging to shed light on dynamic cellular events. However, processes such as mammalian fertilization and embryogenesis are generally inaccessible for direct imaging. In consequence, how the oviduct (fallopian tube) facilitates the transport of gametes and preimplantation embryos continues to be unanswered. Here we present a combination of intravital window and optical coherence tomography for dynamic, volumetric, in vivo imaging of oocytes and embryos as they are transported through the mouse oviduct. We observed location-dependent circling, oscillating, and long-distance bi-directional movements of oocytes and embryos that suggest regulatory mechanisms driving transport and question established views ...

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      Mentions: Baylor College of Medicine

    8. The unexpected journey of the egg and the embryo through the fallopian tube

      Explore Medical Xpress Developmental Biology , Gynecology
      The unexpected journey of the egg and the embryo through the fallopian tube

      The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging. Looking to shed new light on the dynamics of the eggs prior to fertilization and embryo transport preceding implantation, researchers at Baylor College of Medicine and Stevens Institute of Technology developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.

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      Mentions: Baylor College of Medicine

    9. Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models

      Explore Optical Coherence Tomography News Gynecology , Funding
      Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models

      Stevens Institute of Technology Receives a 2021 NIH Grant for $182,953 for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models. The principal investigator is Shang Wang. Below is a summary of the proposed work. Tubal ectopic pregnancy (tEP) is a life-threatening reproductive disorder affecting nearly 2% of pregnancies in developed countries. The etiology of tEP is far from resolved, leaving no way to design preventive measures and few strategies for early diagnosis. Investigating how a tEP forms and develops has been extremely difficult. Because it is unethical to access human oviduct (fallopian tube) during healthy pregnancies ...

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      Mentions: National Institutes of Health

    10. Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

      Explore Nature Publishing Group Gynecology
      Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

      In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were ...

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      Mentions: Zhengzhou Ultralucia Medical Technology Co., Ltd

    11. Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

      Explore Home - ClinicalTrials.gov Gynecology , Clinical Trials
      Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

      We have recently developed and optimized a vaginal Optical Coherence tomography /angiography endoscopy imaging system. This technology is able to obtain a comprehensive image of the vaginal epithelium, blood vessels, and lamina propria. The primary focus of this study is establishing the Optical Coherence Tomography system's capability of capturing vaginal changes that occur before and after menopause, as well as before and after treatment with fractional-CO2 laser therapy.

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      Mentions: UC Irvine

    12. Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Explore OSA | OSA Publishing Gynecology
      Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge of tissue-specific fiber architecture. This study explores image processing, enhancement, segmentation, and detection algorithms to map 3-D collagen fiber architecture from OCT images alone. 3-D fiber mapping, histogram analysis, and 3-D tractography revealed fiber groupings and macro-organization previously unseen in uterine tissue samples. We applied our method on centimeter-scale mosaic OCT volumes of uterine tissue blocks from pregnant and non-pregnant specimens revealing a complex, patient-specific network of fibrous collagen and myocyte bundles.

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      Mentions: Columbia University Christine P. Hendon

    13. Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography

      Explore IOPscience Gynecology
      Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography

      To preserve the fertility of young female cancer patients, ovarian tissue cryopreservation and transplantation have been investigated as next-generation reproductive medical technologies. Non-invasive visualization of follicles in ovarian tissue and cryopreservation of higher density tissue is essential for effective transplantation. We proposed the use of optical coherence tomography (OCT) that can noninvasively visualize the internal structure of the ovarian tissue. However, a method for quantifying cell density has not yet been established because of the lack of available techniques to visualize follicles noninvasively. We proposed the use of a convolutional neural network (CNN) to extract small features from medical images ...

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    14. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Explore LWW Online Gynecology
      Optical Vaginal Biopsy Using Optical Coherence Tomography

      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO 2 laser therapy were assessed ...

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      Mentions: UC Irvine

    15. Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

      Explore OSA | OSA Publishing Gynecology
      Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

      An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young’s modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young’s modulus can be accurately estimated using this scheme. We then measured the Young’s modulus of rodent cervical tissues acquired at different gestational ages ...

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      Mentions: Johns Hopkins University

    16. Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva

      Explore Журнал СТМ Gynecology
      Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva

      The aim of the study was to test the method of optical coherence tomography (OCT) for its ability to obtain images of blood and lymphatic vessels of the vulva. Materials and Methods. The study was performed using a multimodal optical coherence tomography device developed in the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod). In this setup, 3D images of 3.4×3.4×1.25 mm are created within 26 s. OCT angiography and OCT lymphangiography are based on the speckle structure analysis. Visualization of blood and lymphatic vessels does not require any additional contrast ...

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      Mentions: Nizhny Novgorod State Medical Academy Institute of Applied Physics

    17. Endometrium imaging using real-time rotational optical coherence tomography imaging system A pilot, prospective and ex-vivo study

      Explore LWW Online Gynecology
      Endometrium imaging using real-time rotational optical coherence tomography imaging system A pilot, prospective and ex-vivo study

      This study aimed to evaluate a novel real-time rotational optical coherence tomography (OCT) imaging system (OCTIS) with a fiber-optic probe to look at endometrium and to correlate the OCTIS images with standard histology. OCT could obtain real-time images resembling histological examination. With recent development of customized probes, it allows OCT to be used in the field of gynecology . This is a pilot, prospective, ex-vivo and observational study. Women underwent hysterectomy for various gynecological conditions were recruited and OCTIS images were obtained from endometrium of 15 fresh uterus specimens immediately after hysterectomy. The excised uterus was cut open and OCTIS imaging ...

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      Mentions: Tomophase Corporation The Chinese University of Hong Kong

    18. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix

      Explore OSA | OSA Publishing Gynecology , Probes
      Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix

      By measuring the phase retardance of a cervical extracellular matrix, our in-house polarization-sensitive optical coherence tomography (PS-OCT) was shown to be capable of (1) mapping the distribution of collagen fibers in the non-gravid cervix, (2) accurately determining birefringence, and (3) measuring the distinctive depolarization of the cervical tissue. A conical beam scan strategy was also employed to explore the 3D orientation of the collagen fibers in the cervix by interrogating the samples with an incident light at 45° and successive azimuthal rotations of 0-360°. Our results confirmed previous observations by X-ray diffraction, suggesting that in the non-gravid human cervix collagen ...

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      Mentions: University of Sheffield

    19. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      Explore Optical Coherence Tomography News Gynecology , Funding
      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives a 2019 NIH Grant for $299,221 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...

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      Mentions: National Institutes of Health University of Arizona

    20. Advances in Colposcopy (Book Chapter)

      Explore Home - Springer Gynecology , Textbooks
      Advances in Colposcopy (Book Chapter)

      Various new technologies have been introduced to improve the diagnostic accuracy of colposcopy, objectively guide to the site of biopsy, and measure the dysplastic nature of the epithelium. These include fluorescence spectroscopy, electrical impedance spectroscopy, diffuse reflectance spectroscopy, and/or their combinations. Other technologies like optical coherence tomography and polarimetric imaging have also been used to define the lesions better. Not only the adjunct use of technology but portable user-friendly devices have been developed which have increased the provision of colposcopy in remote areas.

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    21. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Explore SPIE Digital Library Gynecology
      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must first be separated from the image background using the process ...

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      Mentions: University of Arizona

    22. Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue

      Explore IOPscience Gynecology
      Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue

      Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Optical Coherence Tomography (OCT) has been applied successfully to experimentally image the ovaries in vivo; however, a robust method for analysis is still required to provide quantitative diagnostic information. Recently, texture analysis has proved to be a useful tool for tissue characterization; unfortunately, existing work in the scope of OCT ovarian imaging is limited to only analyzing 2D sub-regions of the image data, discarding information encoded in the full image area, as well as in the depth dimension. Here we address these challenges by ...

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      Mentions: University of Arizona

    23. Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue

      Explore arxiv.org Gynecology , Microscopy
      Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue

      : Ultrahigh-resolution optical coherence microscopy (OCM) has recently demonstrated its potential for accurate diagnosis of human cervical diseases. One major challenge for clinical adoption, however, is the steep learning curve clinicians need to overcome to interpret OCM images. Developing an intelligent technique for computer-aided diagnosis (CADx) to accurately interpret OCM images will facilitate clinical adoption of the technology and improve patient care. Methods: 497 high-resolution 3-D OCM volumes (600 cross-sectional images each) were collected from 159 ex vivo specimens of 92 female patients. OCM image features were extracted using a convolutional neural network (CNN) model, concatenated with patient information (e.g ...

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      Mentions: Lehigh University

    24. New Testing for Ovarian Cancer

      Explore veteranstoday.com Gynecology , Oncology
      New Testing for Ovarian Cancer

      Optical coherence tomography (OCT) and multispectral fluorescence imaging (MFI) have demonstrated promising results in the early detection of ovarian cancer, as detailed in an abstract presented at the 12th Biennial Ovarian Cancer Research Symposium, held September 13–15 in Seattle. “There appear to be unique markers in the blood of ovarian cancer patients, months and years prior to diagnosis, and optical imaging techniques can distinguish [between] normal, cancer, and benign abnormalities [in] ovarian and fallopian tube tissue,” said presenter Jennifer K. Barton, PhD, professor of biomedical engineering at the University of Arizona in Tucson. Barton and colleagues are developing a ...

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      Mentions: University of Arizona
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