Gynecology -Optical Coherence Tomography News

Articles in category: Gynecology

1-24 of 133 1 2 3 4 5 6 »
1. Role of non-carious cervical lesions multicausality in the behavior of respective restorations
  
  Explore ScienceDirect Apr 22 2022 Gynecology
  
  Objectives: To evaluate biocorrosion and eccentric occlusal loading interplay in marginal quality of cervical restorations. Methods: Cervical wedge-shaped cavities were prepared in extracted premolars and restored with a composite. Premolars underwent either an erosive challenge (E: 1% citric acid/10 min), eccentric occlusal loading (EOL: 150 N/2.5 Hz/10 6 cycles), E before EOL (E + EOL), E intermediate to EOL (EOL/E/EOL), E after EOL (EOL + E), or no E or EOL (C: control). Marginal quality was analyzed based on a series of Optical Coherence Tomography images. Each of the margins was assigned a gap score (0 ...
  Read Full Article
  
  Comment
  
  Mentions: University of São Paulo
2. In vivo evaluation of endometrium through dual-modality intrauterine endoscopy
  
  Explore Optica Publishing Group Apr 5 2022 Gynecology
  
  Female infertilities are highly associated with poor endometrial receptivity. A receptive endometrium is generally characterized by the normal uterine cavity, intact endometrial surface, appropriate endometrial thickness, and echo pattern. Acquiring comprehensive structural information is the prerequisite of endometrium assessment, which is beyond the ability of any single-modality imaging method. In this paper, we introduce a custom-made intrauterine dual-modality (OCT/ultrasound) endoscopic imaging system and achieve in vivo imaging of rabbit uteri, for the first time to our knowledge. The endometrial features of the injured uteri in both ultrasonic and OCT images are consistent with their corresponding pathology. The quantified parameters ...
  Read Full Article
  
  Comment
  
  Mentions: Chinese Academy of Sciences
3. Cervical optical coherence tomography image classification based on contrastive self-supervised texture learning
  
  Explore aapm.onlinelibrary.wiley.com Mar 29 2022 Gynecology
  
  Background: Cervical cancer seriously affects the health of the female reproductive system. Optical coherence tomography (OCT) emerged as a non-invasive, high-resolution imaging technology for cervical disease detection. However, OCT image annotation is knowledge-intensive and time-consuming, which impedes the training process of deep-learning-based classification models. Purpose: This study aims to develop a computer-aided diagnosis (CADx) approach to classifying in-vivo cervical OCT images based on self-supervised learning. Methods: In addition to high-level semantic features extracted by a convolutional neural network (CNN), the proposed CADx approach designs a contrastive texture learning (CTL) strategy to leverage unlabeled cervical OCT images' texture features. We conducted ...
  Read Full Article
  
  Comment
4. Study on the application and imaging characteristics of optical coherence tomography in vulva lesions
  
  Explore Nature Publishing Group Mar 14 2022 Gynecology
  
  In this study, a prospective study was conducted by using optical coherence tomography (OCT) in the in vivo detection of vulvar diseases. The clinical efficacy of the OCT we investigated in the detection of vulvar diseases, and the characteristics of the OCT images were defined. Overall, this study recruited 63 patients undergoing the colposcopy for vulvar lesions in three Chinese hospitals from December 20th, 2018 and September 24th, 2019. The colposcopy and the OCT examination were performed successively, and the OCT images were compared with the relevant tissue sections to characterize different lesions. The OCT diagnoses where categorized into 7 ...
  Read Full Article
  
  Comment
5. Ovarian cancer detection using optical coherence tomography and convolutional neural networks
  
  Explore Home - Springer Jan 31 2022 Gynecology
  
  Ovarian cancer has the sixth-largest fatality rate in the United States among all cancers. A non-surgical assay capable of detecting ovarian cancer with acceptable sensitivity and specificity has yet to be developed. However, such a discovery would profoundly impact the pace of the treatment and improvement to patients’ quality of life. Achieving such a solution requires high-quality imaging, image processing, and machine learning to support an acceptably robust automated diagnosis. In this work, we propose an automated framework that learns to identify ovarian cancer in transgenic mice from optical coherence tomography (OCT) recordings. Classification is accomplished using a neural network ...
  Read Full Article
  
  Comment
  
  Mentions: University of Arizona
6. Researchers pilot 'itty bitty' device for earlier ovarian cancer detection
  
  Explore Home | University of Arizona News Jan 18 2022 Gynecology , Oncology
  
  Due to a lack of effective screening and diagnostic tools, more than three-fourths of ovarian cancer cases are not found until the cancer is in an advanced stage. As a result, fewer than half of all women with ovarian cancer survive more than five years after diagnosis. Jennifer Barton , director of the University of Arizona BIO5 Institute and Thomas R. Brown Distinguished Chair in Biomedical Engineering , has spent years developing a device small enough to image the fallopian tubes – narrow ducts connecting the uterus to the ovaries – and search for signs of early-stage cancer. Dr. John Heusinkveld has now used ...
  Read Full Article
  
  Comment
  
  Mentions: FDA University of Arizona
7. Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.
  
  Explore Optical Coherence Tomography News Oct 11 2021 Gynecology , Funding
  
  Glannaventa Receives a 2021 NIH NCI SBIR Grant for $399,331 for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. The principal investigator is John Black. Below is a summary of the proposed work. This year, over 22,000 women in the U.S. will be diagnosed with ovarian cancer (OvCa), and ~14,000 will die from this disease. Approximately 9,000 of these deaths occur from high-grade serous epithelial cancer (HGSC) primarily because of our inability to detect the disease in its early stages. OvCa accounts for 2.5% of all ...
  Read Full Article
  
  Comment
  
  Mentions: Glannaventa, Inc.
8. University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy
  
  Explore Optical Coherence Tomography News Sep 29 2021 Gynecology , Funding
  
  University of California at Irvine Receives a 2021 NIH Grant for $1,946,945 for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Genitourinary Syndrome of Menopause (GSM) affects up to 50% of women and negatively affects their quality of life with regard to general health and sexual function. Hormone therapy is the most commonly performed procedure to supplement the natural estrogen, but health risk associated with long-term therapy exists. Recently, an alternative therapy has been proposed using fractional CO2 micro- ablation ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health UC Irvine
9. Endometrium optical coherence tomography (OCT) and histomorphometry in implantation window and their relationships with reproductive failure and implantation outcome
  
  Explore Journals Aug 14 2021 Gynecology
  
  Study question How do endometrium OCT image characteristics during peri-implantation window correlate with histomorphometry and associate with implantation outcomes in women with reproductive failure? Summary answer Endometrium OCT intensity correlated with stromal cell density and gland size. Endometrium with recurrent implantation failure had low OCT intensity but reversed in successful implantation. What is known already OCT is a non-invasive imaging technique using low energy near-infrared light to capture micrometer-scale resolution images from optical scattering media. An image produced by OCT resembles tissue architecture observed in histology, so OCT imaging has been regarded as “optical biopsy”. Our previous findings demonstrated OCT ...
  Read Full Article
  
  Comment
  
  Mentions: The Chinese University of Hong Kong University of Hong Kong
10. Pelvic Organs Prolapse Treatment Using Neodymium Laser
  
  Explore Home - ClinicalTrials.gov Aug 11 2021 Gynecology , Clinical Trials
  
  The aim of this prospective study is investigation of efficiency and safety of medical device "Magic Max" for preoperative treatment of pelvic organs prolapse I-II degree of severity. To assess the condition of the vaginal walls and vulva before and after laser treatment, the following methods will be used: ultrasonography with Doppler ultrasonography, vaginal health index, histological examination, immunohistochemical examination, optical coherence tomography (OCT) (elastography). Pelvic Floor Distress Inventory Questionnaire (PFDI-20), The Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF), Pelvic Floor Impact Questionnaire (PFIQ-7) will be used to collect feedback on ...
  Read Full Article
  
  Comment
11. Multidimensional Data Processing for Optical Coherence Tomography Imaging (Thesis)
  
  Explore ProQuest Jul 29 2021 Gynecology , Student Theses
  
  Optical Coherence Tomography (OCT) is a medical imaging technique which distinguishes itself by acquiring microscopic resolution images in-vivo at millimeter scale fields of view. The resulting in images are not only high-resolution, but often multi-dimensional to capture 3-D biological structures or temporal processes. The nature of multi-dimensional data presents a unique set of challenges to the OCT user that include acquiring, storing, and handling very large datasets, visualizing and understanding the data, and processing and analyzing the data. In this dissertation, three of these challenges are explored in depth: sub-resolution temporal analysis, 3-D modeling of fiber structures, and compressed sensing ...
  Read Full Article
  
  Comment
  
  Mentions: Columbia University
12. In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct
  
  Explore Cell Jul 14 2021 Developmental Biology , Gynecology
  
  Developmental biologists have always relied on imaging to shed light on dynamic cellular events. However, processes such as mammalian fertilization and embryogenesis are generally inaccessible for direct imaging. In consequence, how the oviduct (fallopian tube) facilitates the transport of gametes and preimplantation embryos continues to be unanswered. Here we present a combination of intravital window and optical coherence tomography for dynamic, volumetric, in vivo imaging of oocytes and embryos as they are transported through the mouse oviduct. We observed location-dependent circling, oscillating, and long-distance bi-directional movements of oocytes and embryos that suggest regulatory mechanisms driving transport and question established views ...
  Read Full Article
  
  Comment
  
  Mentions: Baylor College of Medicine
13. The unexpected journey of the egg and the embryo through the fallopian tube
  
  Explore Medical Xpress Jul 13 2021 Developmental Biology , Gynecology
  
  The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging. Looking to shed new light on the dynamics of the eggs prior to fertilization and embryo transport preceding implantation, researchers at Baylor College of Medicine and Stevens Institute of Technology developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.
  Read Full Article
  
  Comment
  
  Mentions: Baylor College of Medicine
14. Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models
  
  Explore Optical Coherence Tomography News Jun 15 2021 Gynecology , Funding
  
  Stevens Institute of Technology Receives a 2021 NIH Grant for $182,953 for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models. The principal investigator is Shang Wang. Below is a summary of the proposed work. Tubal ectopic pregnancy (tEP) is a life-threatening reproductive disorder affecting nearly 2% of pregnancies in developed countries. The etiology of tEP is far from resolved, leaving no way to design preventive measures and few strategies for early diagnosis. Investigating how a tEP forms and develops has been extremely difficult. Because it is unethical to access human oviduct (fallopian tube) during healthy pregnancies ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health
15. Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
  
  Explore Nature Publishing Group Apr 7 2021 Gynecology
  
  In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were ...
  Read Full Article
  
  Comment
  
  Mentions: Zhengzhou Ultralucia Medical Technology Co., Ltd
16. Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy
  
  Explore Home - ClinicalTrials.gov Feb 4 2021 Gynecology , Clinical Trials
  
  We have recently developed and optimized a vaginal Optical Coherence tomography /angiography endoscopy imaging system. This technology is able to obtain a comprehensive image of the vaginal epithelium, blood vessels, and lamina propria. The primary focus of this study is establishing the Optical Coherence Tomography system's capability of capturing vaginal changes that occur before and after menopause, as well as before and after treatment with fractional-CO2 laser therapy.
  Read Full Article
  
  Comment
  
  Mentions: UC Irvine
17. Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT
  
  Explore OSA | OSA Publishing Nov 6 2020 Gynecology
  
  Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge of tissue-specific fiber architecture. This study explores image processing, enhancement, segmentation, and detection algorithms to map 3-D collagen fiber architecture from OCT images alone. 3-D fiber mapping, histogram analysis, and 3-D tractography revealed fiber groupings and macro-organization previously unseen in uterine tissue samples. We applied our method on centimeter-scale mosaic OCT volumes of uterine tissue blocks from pregnant and non-pregnant specimens revealing a complex, patient-specific network of fibrous collagen and myocyte bundles.
  Read Full Article
  
  Comment
  
  Mentions: Columbia University Christine P. Hendon
18. Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography
  
  Explore IOPscience Oct 27 2020 Gynecology
  
  To preserve the fertility of young female cancer patients, ovarian tissue cryopreservation and transplantation have been investigated as next-generation reproductive medical technologies. Non-invasive visualization of follicles in ovarian tissue and cryopreservation of higher density tissue is essential for effective transplantation. We proposed the use of optical coherence tomography (OCT) that can noninvasively visualize the internal structure of the ovarian tissue. However, a method for quantifying cell density has not yet been established because of the lack of available techniques to visualize follicles noninvasively. We proposed the use of a convolutional neural network (CNN) to extract small features from medical images ...
  Read Full Article
  
  Comment
19. Optical Vaginal Biopsy Using Optical Coherence Tomography
  
  Explore LWW Online Feb 10 2020 Gynecology
  
  Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO 2 laser therapy were assessed ...
  Read Full Article
  
  Comment
  
  Mentions: UC Irvine
20. Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment
  
  Explore OSA | OSA Publishing Jan 14 2020 Gynecology
  
  An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young’s modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young’s modulus can be accurately estimated using this scheme. We then measured the Young’s modulus of rodent cervical tissues acquired at different gestational ages ...
  Read Full Article
  
  Comment
  
  Mentions: Johns Hopkins University
21. Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva
  
  Explore Журнал СТМ Jan 4 2020 Gynecology
  
  The aim of the study was to test the method of optical coherence tomography (OCT) for its ability to obtain images of blood and lymphatic vessels of the vulva. Materials and Methods. The study was performed using a multimodal optical coherence tomography device developed in the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod). In this setup, 3D images of 3.4×3.4×1.25 mm are created within 26 s. OCT angiography and OCT lymphangiography are based on the speckle structure analysis. Visualization of blood and lymphatic vessels does not require any additional contrast ...
  Read Full Article
  
  Comment
  
  Mentions: Nizhny Novgorod State Medical Academy Institute of Applied Physics
22. Endometrium imaging using real-time rotational optical coherence tomography imaging system A pilot, prospective and ex-vivo study
  
  Explore LWW Online Nov 5 2019 Gynecology
  
  This study aimed to evaluate a novel real-time rotational optical coherence tomography (OCT) imaging system (OCTIS) with a fiber-optic probe to look at endometrium and to correlate the OCTIS images with standard histology. OCT could obtain real-time images resembling histological examination. With recent development of customized probes, it allows OCT to be used in the field of gynecology . This is a pilot, prospective, ex-vivo and observational study. Women underwent hysterectomy for various gynecological conditions were recruited and OCTIS images were obtained from endometrium of 15 fresh uterus specimens immediately after hysterectomy. The excised uterus was cut open and OCTIS imaging ...
  Read Full Article
  
  Comment
  
  Mentions: Tomophase Corporation The Chinese University of Hong Kong
23. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix
  
  Explore OSA | OSA Publishing Jul 25 2019 Gynecology , Probes
  
  By measuring the phase retardance of a cervical extracellular matrix, our in-house polarization-sensitive optical coherence tomography (PS-OCT) was shown to be capable of (1) mapping the distribution of collagen fibers in the non-gravid cervix, (2) accurately determining birefringence, and (3) measuring the distinctive depolarization of the cervical tissue. A conical beam scan strategy was also employed to explore the 3D orientation of the collagen fibers in the cervix by interrogating the samples with an incident light at 45° and successive azimuthal rotations of 0-360°. Our results confirmed previous observations by X-ray diffraction, suggesting that in the non-gravid human cervix collagen ...
  Read Full Article
  
  Comment
  
  Mentions: University of Sheffield
24. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
  
  Explore Optical Coherence Tomography News Jul 23 2019 Gynecology , Funding
  
  University of Arizona Receives a 2019 NIH Grant for $299,221 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health University of Arizona
1-24 of 133 1 2 3 4 5 6 »