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(4 articles) University of Connecticut
(3 articles) University of Arizona
(2 articles) University of Central Florida
(2 articles) University of Texas Medical Branch
(1 articles) Ludwig Maximilians Universität München
(1 articles) World Health Organization
(1 articles) Yonsei University
(1 articles) Russian Academy of Sciences
(1 articles) Academic Medical Center at the University of Amsterdam
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Diagnostic Efficacy of Real-Time Optical Coherence Tomography in the Management of Preinvasive and Invasive Neoplasia of the Uterine Cervix
Explore Article LWW Online (Feb 6 2010) Gynecology , Oncology
Objective: Determine the sensitivity and specificity of optical coherence tomography (OCT) as an adjunct to colposcopy in the detection of cervical intraepithelial neoplasia (CIN) grade 2 or higher in a real-time clinical evaluation. Background: Optical coherence tomography (OCT) uses infrared light similar to ultrasound pulse-echo imaging. Image resolution is optimal in the 1-to-3-mm range. This study is the third in our series of OCT investigations and our first real-time clinical trial. The study was conducted at the Peking University Shenzhen Hospital, Shenzhen, China. Methods: Nonpregnant women 18 years or older with abnormal cervical cytologic findings or a positive high-risk human ...
Comment on Article Mentions: Imalux Nancy J. Tresser
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Cervical Soft Tissue Motion Measurement by Optical Coherence Tomography
Explore Article SpringerLink Home (Jan 1 2010) Gynecology , Oncology , Otolaryngology
To design a semi-automatic laser scalpel for tissue resection in the area of neck masses it was necessary to examine the biomechanic behavour of these tissues. The aim was to identify if and to what extent (amplitude and velocity) the tissues shift due to respiration and circulation. This is important since these movements have to be followed by the laser scalpel. At defined points on the neck surface onedimensional (1-D) time related Optical Coherence Tomography OCT measurements were recorded. Tissue shifting in the direction of the OCT-sightaxis was quantified. The preliminary results of these basic experiments shown here will be ... -
Laparoscopic optical coherence tomography imaging of human ovarian cancer
Explore Article Optical Coherence Tomography News (Jun 20 2009) Gynecology , Oncology
Feature Of The Week 6/21/09: Ovarian cancer is the fourth leading cause of cancer-related death among women in the US, largely attributed to late detection due to unreliable symptomology and screening tools without adequate resolution and specificity. As a result, ovarian cancer is often diagnosed a
Comment on Article Mentions: Jennifer K. Barton University of Arizona Molly Brewer
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Laparoscopic optical coherence tomography imaging of human ovarian cancer
Explore Article ScienceDirect (Jun 2 2009) Gynecology , Oncology
Objectives Ovarian cancer is the fourth leading cause of cancer-related death among women in the US largely due to late detection secondary to unreliable symptomology and screening tools without adequate resolution. Optical coherence tomography (OCT) is a recently emerging imaging modality with promise in ovarian cancer diagnostics, providing non-destructive subsurface imaging at imaging depths up to 2 mm with near-histological grade resolution (10–20 μm). In this study, we developed the first ever laparoscopic OCT (LOCT) device, evaluated the safety and feasibility of LOCT, and characterized the microstructural features of human ovaries in vivo. Methods A custom LOCT device was fabricated ...Comment on Article Mentions: Jennifer K. Barton University of Arizona University of Connecticut
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In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging
Explore Article opticsinfobase.org (May 12 2009) Gynecology , Oncology
In vitro three-dimensionalmodels for metastatic ovarian cancer have been useful for recapitulating the human disease. These spheroidal tumor cultures, however, can grow in excess of 1 mm in diameter, which are difficult to visualize without suitable imaging technology.Optical coherence tomography (OCT) is an ideal live imaging method for non-perturbatively visualizing these complex systems. OCT enabled detailed observations of the model at both nodular and cellular levels, revealing growth dynamics not previously observed. The development of a time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer.
Comment on Article Mentions: Johannes F. de Boer Massachusetts General Hospital Harvard University
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Optical coherence tomography as a non-invasive imaging technique for examination of cervical tissue
Explore Article ScienceDirect (May 8 2009) Gynecology , Oncology
Objective Optical coherence tomography (OCT) is a non-invasive high-resolution real-time imaging technique that permits delineation of features up to 2 mm in depth. The purpose of this study was to examine the capabilities of OCT in characterizing cancerous and precancerous lesions of the uterine cervix. Patients and methods We conducted a single-institution, review board-approved, prospective study on the use of OCT as an adjunct to standard colposcopy and biopsy in 25 women with suspected cervical intraepithelial neoplasia (CIN). OCT images of suspicious areas were obtained before biopsy, interpreted in real time and subsequently compared with the corresponding histology. Results We ...Comment on Article Mentions: Ludwig Maximilians Universität München
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High Resolution Imaging of Epithelial Injury in the Sheep Cervicovaginal Tract: A Promising Model for Testing Safety of Candidate Microbicides
Explore Article Sexually Transmitted Diseases (Apr 26 2009) Gynecology
Abstract: Background: Access to readily available large animal models and sensitive noninvasive techniques that can be used for the evaluation of microbicide-induced changes in tissue could significantly facilitate preclinical evaluations of microbicide safety. The sheep cervicovaginal tract, with stratified squamous epithelium similar to humans, holds promise as a large animal model used before nonhuman primates. In addition, optical coherence tomography (OCT) could enable high resolution visualization of tissue morphology and noninvasive assessment of microbicide-induced epithelial injury. Methods: We evaluated the dose response of sheep cervicovaginal tract to benzalkonium chloride (BZK). Twenty sheep received treatment with phosphate-buffered saline or BZK solution ...Comment on Article Mentions: Massoud Motamedi University of Texas Medical Branch World Health Organization
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A prototype hybrid intraoperative probe for ovarian cancer detection
Explore Article opticsinfobase.org (Apr 19 2009) Gynecology , Oncology , Probes
A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for ...
Comment on Article Mentions: Molly Brewer Shikui Yan Yueli Chen
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Imalux® Corporation and Preventive Oncology International®, Inc. Differentiate Grades of Pre-Invasive Cervical Dysplasia with Niris Optical Coherence Tomography Imaging System
Explore Article businesswire.com (Feb 24 2009) Gynecology , Oncology , Other Business News
Imalux Corporation and Preventive Oncology International, Inc. (POI) conducted two studies to determine the diagnostic efficacy of “real time” Optical Coherence Tomography (OCT). The first study was held in December 2007 and the second in April 2008. Both IRB-approved studies took place in China in partnership with the Peking University Shenzhen Hospital and the Renmin Hospital in Buyi-Miao Autonomous District of Guizhou Province. Two thousand (2000) women participated in the studies and approximately two thousand eight hundred (2,800) OCT images were taken and were compared to diagnostic impression and pathologic findings to determine the accuracy of OCT. The studies yielded ...Comment on Article Mentions: Imalux Imalux Niris Nancy J. Tresser
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Digital colposcopy: ready for use? An overview of literature
Explore Article www3.interscience.wiley.com (Dec 17 2008) Gynecology
The aims of this review were to summarise the various methods of digital colposcopy and to provide an overview of their efficacy. We conducted a literature search and focused on papers that described a technique for colposcopy, other than conventional colposcopy, and compared this with conventional colposcopy and/or histology and included digitalisation of the process. All papers have been classified in one of the following categories: digital imaging and telecolposcopy, spectroscopy, computerised colposcopy, optical coherence tomography and confocal microcolposcopy. Among the most promising developments is spectroscopy, allowing a more or less automated analysis and interpretation of the colposcopic image.Comment on Article Mentions: Academic Medical Center at the University of Amsterdam
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Review: Optical Micrometer Resolution Scanning for Non-invasive Grading of Precancer in the Human Uterine Cervix
Explore Article TCRT Online (Dec 3 2008) Gynecology
Management of cervical precancer is archetypal for other cancer prevention programmes but has to consider diagnostic and logistic challenges. Numerous optical tools are emerging for non-destructive near real-time early diagnosis of precancerous lesions of the cervix. Non-destructive, real-time imaging modalities have reached pre-commercial status, but high resolution mapping tools are not yet introduced in clinical settings. The NCBI PubMed web page was searched using the keywords ‘CIN diagnosis’ and the combinations of ‘cervix {confocal, optical coherence tomography, ftir, infrared, Raman, vibrational, spectroscopy}’. Suitable titles were identified and their relevant references followed. Challenges in precancer management are discussed. The following tools ...Comment on Article Mentions: Florian Bazant-Hegemark
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Imalux Collaborates with Preventative Oncology International™ in Study of Cervical Cancer in China
Explore Article Welcome to Imalux (Jun 24 2008) Gynecology , Oncology , Urology
Comment on Article Mentions: Imalux Nancy J. Tresser Russian Academy of Sciences
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Optical diagnosis of cervical intraepithelialneoplasm (cin) using polarization-sensitive optical coherence tomography
Explore Article opticsinfobase.org (Feb 12 2008) Gynecology
Sang-Won Lee, Ji-Yeong Yoo, Jin-Ho Kang, Moon-Sik Kang, Soon-Hee Jung, Yosep Chong, Dong-Su Cha, Kyung-Hee Han, Beop-Min KimWe present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by the scattering changes induced by cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions of ... [Opt. Express 16, 2709-2719 (2008)]Comment on Article Mentions: Sang-Won Lee Yonsei University
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Laparoscopic optical coherence tomographic imaging of human ovarian cancer
Explore Article SPIE Digital Library (Feb 5 2008) Gynecology , Oncology
Ovarian cancer is the fourth leading cause of cancer-related death among women in the United States. If diagnosed at an early stage, the 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of all cases are diagnosed at the early, localized stag ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 685107 (2008)] published Tue Feb 5, 2008.Comment on Article Mentions: Jennifer K. Barton University of Arizona Lida P. Hariri
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Application of Optical Coherence Tomography for Monitoring Changes in Cervicovaginal Epithelial Morphology in Macaques: Potential for Assessment of Microbicide Safety.
Explore Article Sexually Transmitted Diseases (Dec 20 2007) Gynecology
Abstract: Objectives: Safety is a primary concern in the development of topical microbicides. Optical coherence tomography (OCT), a high-resolution, in-depth cross-sectional imaging modality, was utilized in conjunComment on Article Mentions: University of Texas Medical Branch
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Three dimensional optical imaging colposcopy
Explore Article PatFT » Page 1 of 1 (Oct 31 2000) Gynecology , Patents
An optical coherence tomography (OCT) and spectral interferometry imaging probe for the automatic screening and diagnosis of cervical and skin cancer in vivo. The probe eliminates the old techniques of having to perform Pap smears followed by a biopsy, known as colposcopy. The novel probe is cylindrical in shape and has a disposable outer plastic shield. Inside the probe is a motor driven rotatable casing having a planar optical fiber bundle array therein. The fiber bundle array has plastic light coupling lenslet arrays on both ends. The exposed end of the probe has one lenslet array disc that couples light ...
Comment on Article Mentions: Jannick P. Rolland University of Central Florida
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Optical disk readout method using optical coherence tomography and spectral interferometry
Explore Article PatFT » Page 1 of 1 (Jun 6 2000) Dermatology , Gynecology , Oncology , Patents
An optical coherence tomography (OCT) and spectral interferometry imaging probe for the automatic screening and diagnosis of cervical and skin cancer in vivo. The probe eliminates the old techniques of having to perform Pap smears followed by a biopsy, known as colposcopy. The novel probe is cylindrical in shape and has a disposable outer plastic shield. Inside the probe is a motor driven rotatable casing having a planar optical fiber bundle array therein. The fiber bundle array has plastic light coupling lenslet arrays on both ends. The exposed end of the probe has one lenslet array disc that couples light ...
Comment on Article Mentions: Jannick P. Rolland University of Central Florida
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