Gynecology -Optical Coherence Tomography News

Articles in category: Gynecology

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1. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
  
  Explore Optical Coherence Tomography News Jul 5 2017 Gynecology , Funding
  
  University of Arizona Receives a 2017 NIH Grant for $334,425 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
2. Colposcopic imaging using visible-light optical coherence tomography
  
  Explore SPIE | Journal May 12 2017 Gynecology
  
  High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6 - mm 2 4.6×4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes ...
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  Mentions: Northwestern University Hao F. Zhang Cheng Sun
3. Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotrop
  
  Explore Conference Proceedings Mar 16 2017 Gynecology
  
  Preterm birth (PTB) presents a serious medical heath concern in both economically developed and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent biological tissue such as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG) microscopy were used to assess cervical collagen content and structure in non-pregnant cervices. In vivo studies using a Mueller Matrix colposcope are underway. Further ...
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  Mentions: University of Florida Amir Gandjbakhche
4. Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary
  
  Explore Nature Publishing Group Mar 14 2017 Gynecology
  
  Except for histological study, there are currently no suitable techniques available for the detection and identification of primordial follicles in ovary of primary ovarian insufficiency patients who have undetectable AMH levels. Also, the ability to locate and quantify follicles on ovarian cortex strips, without fixation, is valuable for patients who could undergo subsequent successful ovarian tissue transplantation. Although optical coherence tomography (OCT) is a well-established high resolution imaging technique without fixation commonly applied in biomedicine, few reports are available on ovarian tissue imaging. In present study, we established standard OCT follicle images at each developmental stage, including the primordial follicle ...
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5. Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy
  
  Explore Conference Proceedings Mar 7 2017 Gynecology
  
  Preterm birth (PTB) presents a serious medical heath concern throughout the world. There is a high incidence of PTB in both developed and developing countries ranging from 11%-15%, respectively. Studies have shown there may be numerous precursors to PTB including infections, genetic predisposition, nutrition and various other morbidities which all lead to a premature disorganization in the cervical collagen resulting in the weakening of the structure designed to keep the fetus in utero. The changes in cervical collagen orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy ...
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  Mentions: Amir Gandjbakhche Florida International University
6. Classification of human ovarian tissue using full field optical coherence tomography
  
  Explore Conference Proceedings Feb 23 2017 Gynecology
  
  The feasibility of a full-field optical coherence tomography (FFOCT) system for rapid wide field optical analysis of normal and malignant human ovarian tissue pathologies was demonstrated. Five features were extracted from the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples.
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  Mentions: Washington University in St. Louis Quing Zhu University of Connecticut
7. Detection of cervical intraepithelial neoplasia by using optical coherence tomography in combination with microscopy
  
  Explore SPIE | Journal Jan 25 2017 Gynecology
  
  Optical coherence tomography (OCT) is a noninvasive high-resolution imaging technique that permits the detection of cancerous and precancerous lesions of the uterine cervix. The purpose of this study was to evaluate a new system that integrates an OCT device into a microscope. OCT images were taken from loop electrosurgical excision procedure (LEEP) specimens under microscopic guidance. The images were blinded with respect to their origin within the microscopic image and analyzed independently by two investigators using initially defined criteria and later compared to the corresponding histology. Sensitivity and specificity were calculated with respect to the correct identification of high-grade squamous ...
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  Mentions: Ludwig Maximilian University of Munich Julia Gallwas Christian Dannecker
8. Noninvasive Detection of Metastases and Follicle Density in Ovarian Tissue Using Full-Field Optical Coherence Tomography
  
  Explore Clinical Cancer Research Dec 13 2016 Gynecology , Oncology
  
  Purpose: Autotransplantation of ovarian tissue can be used to restore fertility in patients with cancer following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods render the ovarian tissue unsuitable for transplantation. Full-field optical coherence tomography (FF-OCT) is an imaging modality that rapidly produces high-resolution histology-like images without the need to fix, freeze, or stain the tissue. In this proof-of-concept study, we investigated whether FF-OCT can be used to detect metastases in ovarian tissue, thereby increasing the safety of ovarian tissue autotransplantation. We also evaluated whether cortical ovarian tissue and follicles remain viable following FF-OCT ...
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  Mentions: Jeroen Eggermont Jouke Dijkstra
9. Classification and analysis of human ovarian tissue using full field optical coherence tomography
  
  Explore OSA | OSA Publishing Nov 24 2016 Gynecology
  
  In this study, a full field optical coherence tomography (FFOCT) system was used to analyze and classify normal and malignant human ovarian tissue. 14 ovarian tissue samples (7 normal, 7 malignant) were imaged with the FFOCT system and five features were extracted by analyzing the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples. A generalized linear model (GLM) classifier was trained using 36 images, and sensitivity of 95.3% and specificity of 91.1% was obtained. 20 images were used to test the model, and a sensitivity ...
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  Mentions: Washington University in St. Louis Quing Zhu Melinda Sanders
10. Jennifer Barton a Leader in Cancer research, Imaging Honored with 2016 SPIE President’s and Directors’ Awards
  
  Explore prweb.com Sep 15 2016 Gynecology , Oncology
  
  Jennifer Barton is the recipient of this year’s SPIE President’s Award and Majid Rabbani of the SPIE Directors’ award, Robert Lieberman, 2016 President of SPIE the international society for optics and photonics, announced at an awards banquet during SPIE Optics + Photonics 2016 in San Diego, California, on 31 August. Barton is interim director of the BIO5 Institute at the University of Arizona, which works to solve complex biology-based problems affecting humanity. She is also professor of biomedical engineering, electrical and computer engineering, optical sciences, and agricultural and bio-systems engineering at UA. Barton is known for her innovative use ...
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  Mentions: Jennifer K. Barton University of Arizona
11. UA engineers zero in on early detection of ovarian cancer
  
  Explore EurekAlert! May 31 2016 Gynecology , Oncology
  
  University of Arizona researcher Jennifer Barton is leading a two-year, $1 million project funded by the National Cancer Institute to identify imaging biomarkers of ovarian cancer, the most deadly gynecological cancer in the United States. This work may enable the first effective screening system for ovarian cancer. "Located deep in the body, with few early symptoms and no effective screening techniques, ovarian cancer has remained stubbornly difficult to understand, much less effectively combat," said Barton, professor of biomedical engineering, electrical and computer engineering, optical sciences, and agricultural and biosystems engineering, and interim director of the UA BIO5 Institute.
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  Mentions: National Cancer Institute Jennifer K. Barton University of Arizona
12. Non-invasive detection of metastases and follicle density in ovarian tissue using full-field optical coherence tomography
  
  Explore Clinical Cancer Research May 18 2016 Gynecology
  
  Purpose: Autotransplantation of ovarian tissue can be used to restore fertility in cancer patients following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods render the ovarian tissue unsuitable for transplantation. Full-field optical coherence tomography (FF-OCT) is an imaging modality that rapidly produces high-resolution histology-like images without the need to fix, freeze, or stain the tissue . In this pro of - of -concept study, we investigated whether FF-OCT can be used to detect metastases in ovarian tissue, thereby increasing the safety of ovarian tissue autotransplantation. We also evaluated whether cortical ovarian tissue and follicles remain viable ...
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  Mentions: Leiden University Jeroen Eggermont Jouke Dijkstra
13. Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo
  
  Explore Conference Proceedings Mar 5 2016 Developmental Biology , Gynecology
  
  Since mouse is a superior model for genetic analysis of human disorders, reproductive studies in mice have significant implications on further understanding of fertility and infertility in humans. Fertilized oocytes are transported through the reproductive tract by motile cilia lining the lumen of the oviduct as well as by oviduct contractions. While the role of cilia is well recognized, ciliary dynamics in the oviduct is not well understood, largely owing to the lack of live imaging approaches. Here, we report in vivo micro-scale mapping of cilia and cilia beat frequency (CBF) in the mouse oviduct using optical coherence tomography (OCT ...
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  Mentions: Baylor College of Medicine Irina V. Larina Shang Wang
14. Improved selection of cortical ovarian strips for autotransplantation of ovarian tissue using full-field optical coherence tomography (FFOCT)
  
  Explore Conference Proceedings Mar 5 2016 Gynecology
  
  Premature ovarian failure is a major concern in women of reproductive age who undergo gonadotoxic cancer treatment. Autotransplantation of frozen-thawed cortical ovarian tissue allows the immediate start of cancer treatment, but risks reintroduction of cancer. Current tumor detection methods compromise the ovarian tissue’s viability and can therefore only be used to exclude the presence of metastases in the cortical ovarian strips that are not transplanted. A non-invasive method is needed that can be used to exclude metastases in the actual ovarian autografts without affecting the tissue’s viability. In this study we applied FFOCT – a non-fixative technique that uses ...
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  Mentions: Leiden University Jeroen Eggermont Jouke Dijkstra
15. Optical Coherence Tomography of the Labial Salivary Glands Reveals Age-Related Differences in Women
  
  Explore Wiley Online Library Nov 6 2015 Gynecology
  
  The labial minor salivary glands (LSGs) play a role in medical research and practice due to their superficial location and involvement in both systemic and localized diseases. Swept-source optical coherence tomography (OCT) is a noninvasive modality that enables in vivo , micrometer resolution, wide-field three-dimensional imaging in seconds. A purpose-built swept-source OCT instrument was employed to acquire three-dimensional datasets covering the area of 2.43 cm 2 of the mucosa of the lower lip to the depth of 3.4 mm in young ( n = 14; mean age ± SD: 27 ± 3 years; body mass index [BMI] 20.4 ± 2.3 kg/m ...
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  Mentions: Maciej Wojtkowski Nicolaus Copernicus University Karol Karnowski
16. Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue
  
  Explore OSA | OSA Publishing Sep 10 2015 Gynecology
  
  In this manuscript, the initial feasibility of a catheter based phase stabilized swept source optical coherence tomography (OCT) system was studied for characterization of the strain inside different human ovarian tissue groups. The ovarian tissue samples were periodically compressed with 500 Hz square wave signal along the axial direction between the surface of an unfocused transducer and a glass cover slide. The displacement and corresponding strain were calculated during loading from different locations for each tissue sample. A total of 27 ex vivo ovaries from 16 patients were investigated. Statistically significant difference (p < 0.001) was observed between the average ...
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  Mentions: Quing Zhu Molly Brewer University of Connecticut
17. The University of Arizona Receives NIH Grant for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging
  
  Explore Optical Coherence Tomography News Sep 8 2015 Gynecology , Oncology , Funding
  
  The University of Arizona Receives 2015 NIH Grant for $572,656 for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging. The principal invetigator is Jennifer Barton. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. Despite advances in treatment strategies, ovarian cancer remains the deadliest gynecological malignancy and the 5th largest cancer killer in women. Located deep in the body, with few early symptoms and no effective screening technique, ovarian cancer has remained stubbornly difficult to understand, much less effectively combat. Ovarian cancer is almost always discovered at ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
18. Optical coherence tomography imaging for analysis of follicular development in ovarian tissue
  
  Explore OSA | OSA Publishing Jun 30 2015 Gynecology
  
  We describe the application of optical coherence tomography (OCT) for noninvasive analysis of follicular development in mouse ovaries. Ovaries contain many follicles and oocytes. Quantification of follicles at various developmental stages is an indication of the ability of an ovary to provide oocytes capable of fertilization. Three-dimensional structural OCT images identified each developmental stage, from a primary follicle (50 μm in diameter) to an antral follicle (350 μm in diameter), in the ovary of a 25.5-day-old mouse. We discovered time-varying OCT signals at the oocytes that differentiated them from surrounding tissues. These signals were clearly enhanced by interframe intensity-based ...
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  Mentions: Yuuki Watanabe Yamagata University
19. Duke University Receives NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health
  
  Explore Optical Coherence Tomography News Apr 7 2015 Gynecology , Funding
  
  Duke University Receives a 2015 NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health. The principal investigator is David Katz. The program began in 2012 and ends in 2016. Below is a summary of the proposed work. Vaginal microbicides offer much promise to prevent sexual transmission of HIV. The pharmacokinetics (PK) of a product (active pharmaceutical ingredient + dosage form) is central to prophylactic functionality (PD). But our ability to measure and predict microbicide PK is currently limited. Further, microbicide PD depends on how product + dosage regimen accommodate a range of conditions of the vaginal environment. These ...
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  Mentions: Duke University
20. Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts
  
  Explore patentscope.wipo.int Apr 1 2015 Gastroenterology , Gynecology , Oncology , Pulmonology , Urology , Patents
  
  A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...
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  Mentions: Zhongping Chen UC Irvine Qifa Zhou
21. A Continuous Fiber Distribution Material Model for Human Cervical Tissue
  
  Explore Journal of Biomechanics Mar 18 2015 Gynecology
  
  The uterine cervix during pregnancy is the vital mechanical barrier which resists compressive and tensile loads generated from a growing fetus. Premature cervical remodeling and softening is hypothesized to result in the shortening of the cervix, which is known to increase a womans risk of preterm birth. To understand the role of cervical material properties in preventing preterm birth, we derive a cervical material model based on previous mechanical, biochemical and histological experiments conducted on nonpregnant and pregnant human hysterectomy cervical tissue samples. In this study we present a three-dimensional fiber composite model that captures the equilibrium material behavior of ...
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  Mentions: Columbia University Christine Hendon
22. Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography
  
  Explore Conference Proceedings Mar 10 2015 Gynecology , Oncology
  
  We have estimated the micro-mechanical properties of ovarian tissue using phase-sensitive swept source optical coherence tomography. Ovary samples were mechanically excited by periodical vibration of an ultrasound transducer. The displacement and strain of the tissues were calculated during loading. Significant difference in strain was observed between the normal and malignant ovary groups, which indicates much softer and heterogeneous tissue structure for malignant ovaries. The initial results show that the phase sensitive swept source optical coherence elastography (OCE) can be an effective tool for characterization of stiffness and other micro-mechanical properties of normal and malignant ovarian tissue.
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  Mentions: Quing Zhu Molly Brewer University of Connecticut
23. Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography
  
  Explore opticsinfobase.org Mar 3 2015 Gynecology
  
  During pregnancy, the uterine cervix is the mechanical barrier that prevents delivery of a fetus. The underlying cervical collagen ultrastructure, which influences the overall mechanical properties of the cervix, plays a role in maintaining a successful pregnancy until term. Yet, not much is known about this collagen ultrastructure in pregnant and nonpregnant human tissue. We used optical coherence tomography to investigate the directionality and dispersion of collagen fiber bundles in the human cervix. An image analysis tool has been developed, combining a stitching method with a fiber orientation measurement, to study axially sliced cervix samples. This tool was used to ...
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  Mentions: Columbia University Christine Hendon
24. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography
  
  Explore AME Publishing Company Feb 21 2015 Gynecology
  
  Background: Endocervical mucus acts as an important barrier to block human immunodeficiency virus (HIV) infection and other sexually transmitted diseases (STDs). Disruption of the mucus layer increases the risk of infection for females. An effective method to image the mucus properties can serve as a pre-screening step to risk-stratify the susceptible population. Methods: We proposed to use optical coherence tomography (OCT) to quantitatively measure the thickness of endocervical mucus. We used a home-built bench-top OCT system to monitor the dynamic change in mucus thickness of a cultivated sample. We also fabricated a prototype endoscopic OCT probe to demonstrate potential in ...
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  Mentions: Northwestern University Ji Yi Hao F. Zhang
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