Gynecology -Optical Coherence Tomography News

Articles in category: Gynecology

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1. Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment
  
  Explore OSA | OSA Publishing Jan 14 2020 Gynecology
  
  An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young’s modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young’s modulus can be accurately estimated using this scheme. We then measured the Young’s modulus of rodent cervical tissues acquired at different gestational ages ...
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  Mentions: Johns Hopkins University Xingde Li
2. Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva
  
  Explore Журнал СТМ Jan 4 2020 Gynecology
  
  The aim of the study was to test the method of optical coherence tomography (OCT) for its ability to obtain images of blood and lymphatic vessels of the vulva. Materials and Methods. The study was performed using a multimodal optical coherence tomography device developed in the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod). In this setup, 3D images of 3.4×3.4×1.25 mm are created within 26 s. OCT angiography and OCT lymphangiography are based on the speckle structure analysis. Visualization of blood and lymphatic vessels does not require any additional contrast ...
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  Mentions: Nizhny Novgorod State Medical Academy Institute of Applied Physics Elena V. Zagaynova
3. Endometrium imaging using real-time rotational optical coherence tomography imaging system A pilot, prospective and ex-vivo study
  
  Explore LWW Online Nov 5 2019 Gynecology
  
  This study aimed to evaluate a novel real-time rotational optical coherence tomography (OCT) imaging system (OCTIS) with a fiber-optic probe to look at endometrium and to correlate the OCTIS images with standard histology. OCT could obtain real-time images resembling histological examination. With recent development of customized probes, it allows OCT to be used in the field of gynecology . This is a pilot, prospective, ex-vivo and observational study. Women underwent hysterectomy for various gynecological conditions were recruited and OCTIS images were obtained from endometrium of 15 fresh uterus specimens immediately after hysterectomy. The excised uterus was cut open and OCTIS imaging ...
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  Mentions: Tomophase Corporation The Chinese University of Hong Kong
4. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix
  
  Explore OSA | OSA Publishing Jul 25 2019 Gynecology , Probes
  
  By measuring the phase retardance of a cervical extracellular matrix, our in-house polarization-sensitive optical coherence tomography (PS-OCT) was shown to be capable of (1) mapping the distribution of collagen fibers in the non-gravid cervix, (2) accurately determining birefringence, and (3) measuring the distinctive depolarization of the cervical tissue. A conical beam scan strategy was also employed to explore the 3D orientation of the collagen fibers in the cervix by interrogating the samples with an incident light at 45° and successive azimuthal rotations of 0-360°. Our results confirmed previous observations by X-ray diffraction, suggesting that in the non-gravid human cervix collagen ...
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  Mentions: Brett E. Bouma Christoph K. Hitzenberger James G. Fujimoto
5. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
  
  Explore Optical Coherence Tomography News Jul 23 2019 Gynecology , Funding
  
  University of Arizona Receives a 2019 NIH Grant for $299,221 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
6. Advances in Colposcopy (Book Chapter)
  
  Explore Home - Springer May 23 2019 Gynecology , Textbooks
  
  Various new technologies have been introduced to improve the diagnostic accuracy of colposcopy, objectively guide to the site of biopsy, and measure the dysplastic nature of the epithelium. These include fluorescence spectroscopy, electrical impedance spectroscopy, diffuse reflectance spectroscopy, and/or their combinations. Other technologies like optical coherence tomography and polarimetric imaging have also been used to define the lesions better. Not only the adjunct use of technology but portable user-friendly devices have been developed which have increased the provision of colposcopy in remote areas.
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7. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
  
  Explore SPIE Digital Library Feb 3 2019 Gynecology
  
  Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must first be separated from the image background using the process ...
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  Mentions: Jennifer K. Barton University of Arizona Photini F. S. Rice
8. Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue
  
  Explore IOPscience Nov 13 2018 Gynecology
  
  Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Optical Coherence Tomography (OCT) has been applied successfully to experimentally image the ovaries in vivo; however, a robust method for analysis is still required to provide quantitative diagnostic information. Recently, texture analysis has proved to be a useful tool for tissue characterization; unfortunately, existing work in the scope of OCT ovarian imaging is limited to only analyzing 2D sub-regions of the image data, discarding information encoded in the full image area, as well as in the depth dimension. Here we address these challenges by ...
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  Mentions: Jennifer K. Barton University of Arizona
9. Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue
  
  Explore arxiv.org Oct 2 2018 Gynecology , Microscopy
  
  : Ultrahigh-resolution optical coherence microscopy (OCM) has recently demonstrated its potential for accurate diagnosis of human cervical diseases. One major challenge for clinical adoption, however, is the steep learning curve clinicians need to overcome to interpret OCM images. Developing an intelligent technique for computer-aided diagnosis (CADx) to accurately interpret OCM images will facilitate clinical adoption of the technology and improve patient care. Methods: 497 high-resolution 3-D OCM volumes (600 cross-sectional images each) were collected from 159 ex vivo specimens of 92 female patients. OCM image features were extracted using a convolutional neural network (CNN) model, concatenated with patient information (e.g ...
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  Mentions: Lehigh University Chao Zhou
10. New Testing for Ovarian Cancer
  
  Explore veteranstoday.com Sep 18 2018 Gynecology , Oncology
  
  Optical coherence tomography (OCT) and multispectral fluorescence imaging (MFI) have demonstrated promising results in the early detection of ovarian cancer, as detailed in an abstract presented at the 12th Biennial Ovarian Cancer Research Symposium, held September 13–15 in Seattle. “There appear to be unique markers in the blood of ovarian cancer patients, months and years prior to diagnosis, and optical imaging techniques can distinguish [between] normal, cancer, and benign abnormalities [in] ovarian and fallopian tube tissue,” said presenter Jennifer K. Barton, PhD, professor of biomedical engineering at the University of Arizona in Tucson. Barton and colleagues are developing a ...
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  Mentions: Jennifer K. Barton University of Arizona
11. Assessment and Diagnosis of Human Ovarian and Colorectal Cancer using Optical and Photoacoustic Imaging (Thesis)
  
  Explore Washington University Open Scholarship Sep 11 2018 Gastroenterology , Gynecology , Student Theses
  
  Optical imaging modalities have the advantage of high resolution, label free, rapid, low cost imaging for both in vivo and ex vivo diagnosis of biological tissues. Optical scattering, which is the main contrast of optical coherence tomography (OCT), is related to elastic scattering components, mainly stromal collagen. Tissue elasticity has recently emerged as an important diagnostic parameter associated with tumor development and progression and is also related to the distribution of structural components such as tissue collagen. We have used an optical coherence tomography elastography (OCTE) system for characterizing the differences in the micro-mechanical properties of benign and malignant human ...
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  Mentions: Washington University in St. Louis
12. 1.7 micron optical coherence tomography for vaginal tissue characterization in vivo
  
  Explore Wiley Online Library Jul 30 2018 Gynecology
  
  Objectives Optical coherence tomography (OCT) can noninvasively visualize in vivo tissue microstructure with high spatial resolution that approaches the histologic level. Currently, OCT studies in gynecology are few and limited to a conventional 1.3 μm center wavelength swept light source which provides high spatial resolution but limited penetration depth. Here, we present a novel endoscopic OCT system with improved penetration depth and high resolution. Methods A novel endoscopic OCT system was developed based on a 1.7 µm swept source laser, which is capable of deeper tissue penetration due to its longer wavelength. To evaluate the performance of system ...
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  Mentions: Zhongping Chen UC Irvine Yan Li
13. Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation
  
  Explore Home - Springer Apr 16 2018 Gynecology
  
  Purpose The purpose of this study was to evaluate the possible clinical application of optical coherence tomography for assessing ovarian reserve in individual specimens of human ovarian tissue for fertility preservation. Methods Ovarian tissue examination by optical coherence tomography was performed before ovarian tissue cryopreservation. Three of the four subjects had hematological disease or cancer, and they faced a threat to their fertility due to impending chemotherapy. One patient underwent ovarian tissue extraction for in vitro activation of dormant follicles as fertility treatment. Results The current full-field optical coherence tomography technique can detect primordial follicles in non-fixed and non-embedded human ...
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14. Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography
  
  Explore SPIE Digital Library Mar 20 2018 Gynecology
  
  The regional heterogeneity study of cervical ultrastructure is critical to understand the cervical functions like cervical softening and dilation. To better understand why the internal os initiates the premature remodeling, we present the heterogeneity study of collagen fiber network, tissue optical property, and mechanical property between the internal os and external os using optical coherence tomography (OCT) and indentation test. Pregnant (n=1) and non-pregnant patients (n=8) were consented after hysterectomy based on approved Institutional Review Board. Cervical axial slices from internal os and external os were imaged with OCT. The tissue ultrastructure was characterized by collagen fiber dispersion ...
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  Mentions: Columbia University Christine P. Hendon
15. 3D visualization of the ovarian tissue scattering coefficient with swept-source optical coherence tomography
  
  Explore SPIE Digital Library Mar 8 2018 Gynecology
  
  It is important to provide timely information to surgeons on diagnosis of a suspicious ovarian tissue before excision to avoid unnecessary surgery, especially for young women. In this report, we introduce a new 3-D surface mapping technique to map ovarian tissue scattering properties by fitting the swept-source optical coherence tomography (SS-OCT) signals to a scattering model. We observed that lower scattering coefficients and heterogeneous spatial distribution were associated with malignant ovarian tissues, and higher scattering coefficients and homogeneous spatial distribution indicated benign ovarian tissues. The initial results suggest that the 3-D scattering map has potential to be an effective tool ...
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  Mentions: Quing Zhu
16. Safeguarding ovarian tissue autotransplantation in cancer patients (Thesis)
  
  Explore Leiden Repository Mar 1 2018 Gynecology , Student Theses
  
  Autotransplantation of ovarian tissue can be used to restore fertility in cancer patients following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods (e.g. PCR analysis, immunohistochemistry) render the ovarian tissue unsuitable for transplantation. As a result, the current tumor detection approach includes assessment of only one or two cortical ovarian fragments that are not transplanted, whereas cortical ovarian tissue fragments that are placed back remain unchecked. The studies described in this thesis focused on determining the risk of reintroducing malignant tumor cells following ovarian tissue autotransplantation using the current tumor detection approach, and ...
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  Mentions: Leiden University
17. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
  
  Explore SPIE Digital Library Feb 13 2018 Gynecology
  
  Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depthresolved, high-resolution images of biological tissue in real time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must rst be separated from the image background using the ...
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  Mentions: Jennifer K. Barton University of Arizona Photini F. S. Rice
18. Prolonged in vivo functional assessment of the mouse oviduct using optical coherence tomography through a dorsal imaging window
  
  Explore Wiley Online Library Jan 23 2018 Developmental Biology , Gynecology
  
  The oviduct (or fallopian tube) serves as an environment for gamete transport, fertilization, and preimplantation embryo development in mammals. Although there has been increasing evidence linking infertility with disrupted oviduct function, the specific roles that the oviduct plays in both normal and impaired reproductive processes remain unclear. The mouse is an important mammalian model to study human reproduction. However, most of the current analyses of the mouse oviduct rely on static histology or 2D visualization, and are unable to provide dynamic and volumetric characterization of this organ. The lack of imaging access prevents longitudinal live analysis of the oviduct and ...
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  Mentions: Baylor College of Medicine Irina V. Larina Shang Wang
19. Optical coherence tomography in gynecology: a narrative review
  
  Explore SPIE Digital Library Dec 8 2017 Gynecology
  
  Modern gynecologic practice requires noninvasive diagnostics techniques capable of detecting morphological and functional alterations in tissues of female reproductive organs. Optical coherence tomography (OCT) is a promising tool for providing imaging of biotissues with high resolution at depths up to 2 mm. Design of the customized probes provides wide opportunities for OCT use in gynecology. This paper contains a retrospective insight into the history of OCT employment in gynecology, an overview of the existing gynecologic OCT probes, including those for combination with other diagnostic modalities, and state-of-the-art application of OCT for diagnostics of tumor and nontumor pathologies of female genitalia ...
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  Mentions: Nizhny Novgorod State Medical Academy Institute of Applied Physics Mikhail Y. Kirillin
20. Label-free analysis of tenofovir delivery to vaginal tissue using co-registered confocal Raman spectroscopy and optical coherence tomography
  
  Explore Journals | PLOS Sep 29 2017 Gynecology
  
  Vaginally applied microbicide products offer a female-controlled strategy for preventing sexual transmission of HIV. Microbicide transport processes are central to their functioning, and there is a clear need for a better understanding of them. To contribute to that end, we developed an assay to analyze mass transport rates of microbicide molecules within the epithelial and stromal layers of polarized vaginal mucosal tissue during contact with a gel vehicle. The assay utilizes a new diffusion chamber mounted in a custom instrument that combines confocal Raman spectroscopy and optical coherence tomography. This measures depth-resolved microbicide concentration distributions within epithelium and stroma. Data ...
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  Mentions: National Institutes of Health Thorlabs GE Healthcare
21. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
  
  Explore Optical Coherence Tomography News Jul 5 2017 Gynecology , Funding
  
  University of Arizona Receives a 2017 NIH Grant for $334,425 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
22. Colposcopic imaging using visible-light optical coherence tomography
  
  Explore SPIE | Journal May 12 2017 Gynecology
  
  High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6 - mm 2 4.6×4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes ...
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  Mentions: Northwestern University Hao F. Zhang Cheng Sun
23. Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotrop
  
  Explore Conference Proceedings Mar 16 2017 Gynecology
  
  Preterm birth (PTB) presents a serious medical heath concern in both economically developed and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent biological tissue such as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG) microscopy were used to assess cervical collagen content and structure in non-pregnant cervices. In vivo studies using a Mueller Matrix colposcope are underway. Further ...
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  Mentions: University of Florida Amir Gandjbakhche
24. Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary
  
  Explore Nature Publishing Group Mar 14 2017 Gynecology
  
  Except for histological study, there are currently no suitable techniques available for the detection and identification of primordial follicles in ovary of primary ovarian insufficiency patients who have undetectable AMH levels. Also, the ability to locate and quantify follicles on ovarian cortex strips, without fixation, is valuable for patients who could undergo subsequent successful ovarian tissue transplantation. Although optical coherence tomography (OCT) is a well-established high resolution imaging technique without fixation commonly applied in biomedicine, few reports are available on ovarian tissue imaging. In present study, we established standard OCT follicle images at each developmental stage, including the primordial follicle ...
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