1. Articles in category: Gynecology

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    1. Baylor College of Medicine Receives NIH Grant for for In vivo investigation of fallopian tube transport

      Baylor College of Medicine Receives NIH Grant for for In vivo investigation of fallopian tube transport

      Baylor College of Medicine Received a 2022 NIH Grant for $67,582 for In vivo investigation of fallopian tube transport. The principal investigator is Dierdre Scully. Below is a summary of the proposed study. The overall objective of this study is to investigate the role of cilia in the fallopian tube (oviduct) in vivo. To accomplish this, my lab has developed a highly innovative, high resolution volumetric optical imaging method that provides unprecendented 4D resolution of the oviduct in its native state. Cilia are traditionally considered to generate the driving force required for oocyte/embryo transport, a theory reinforced by ...

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    2. A pilot and ex-vivo study of examination of endometrium tissue by catheter based optical coherence tomography

      A pilot and ex-vivo study of examination of endometrium tissue by catheter based optical coherence tomography

      Objective This study aimed to distinguish ex-vivo normal and abnormal endometrium tissue samples histologically by catheter based optical coherence tomography (OCT). Methods A total of 72 ex-vivo endometrium specimens were obtained from June 2018 to March 2021 and were imaged fresh after hysterectomy. The scanned region of endometrium was excised for histological examination and endometrium OCT images were precisely compared to corresponding histological images. Meanwhile endometrium OCT images were analyzed quantitatively with intensity of backscattered light in region of interest (ROI) and maximum penetration depth of the OCT signal. Blinded qualitative analysis on endometrium OCT images was performed by 2 ...

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    3. Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer

      Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer

      Ovarian carcinoma (OC) forms outgrowths that extend from the outer surface of an afflicted organ into the peritoneum. OC outgrowth formation is poorly understood due to the limited availability of cell culture models examining the behavior of cells that form outgrowths. Prompted by immunochemical evaluation of extracellular matrix (ECM) components in human tissues, laminin and collagen-rich ECM-reconstituted cell culture models amenable to studies of cell clusters that can form outgrowths are developed. It is demonstrated that ECM promotes outgrowth formation in fallopian tube non-ciliated epithelial cells (FNE) expressing mutant p53 and various OC cell lines. Outgrowths are initiated by cells ...

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    4. OCT Evaluation of Vaginal Epithelial Thickness during CO2 Laser Treatment: A Pilot Study

      OCT Evaluation of Vaginal Epithelial Thickness during CO2 Laser Treatment: A Pilot Study

      Genitourinary syndrome of menopause (GSM) negatively affects more than half of postmenopausal women. Energy-based therapy has been explored as a minimally invasive treatment for GSM; however, its mechanism of action and efficacy is controversial. Here, we report on a pilot imaging study conducted on a small group of menopause patients undergoing laser treatment. Intravaginal optical coherence tomography (OCT) endoscope was used to quantitatively monitor the changes in the vaginal epithelial thickness (VET) during fractional-pixel CO 2 laser treatment. 11 patients with natural menopause and 1 surgically induced menopause patient were recruited in this clinical study. Following the laser treatment, the ...

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      Mentions: UC Irvine
    5. Role of non-carious cervical lesions multicausality in the behavior of respective restorations

      Role of non-carious cervical lesions multicausality in the behavior of respective restorations

      Objectives: To evaluate biocorrosion and eccentric occlusal loading interplay in marginal quality of cervical restorations. Methods: Cervical wedge-shaped cavities were prepared in extracted premolars and restored with a composite. Premolars underwent either an erosive challenge (E: 1% citric acid/10 min), eccentric occlusal loading (EOL: 150 N/2.5 Hz/10 6 cycles), E before EOL (E + EOL), E intermediate to EOL (EOL/E/EOL), E after EOL (EOL + E), or no E or EOL (C: control). Marginal quality was analyzed based on a series of Optical Coherence Tomography images. Each of the margins was assigned a gap score (0 ...

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    6. In vivo evaluation of endometrium through dual-modality intrauterine endoscopy

      In vivo evaluation of endometrium through dual-modality intrauterine endoscopy

      Female infertilities are highly associated with poor endometrial receptivity. A receptive endometrium is generally characterized by the normal uterine cavity, intact endometrial surface, appropriate endometrial thickness, and echo pattern. Acquiring comprehensive structural information is the prerequisite of endometrium assessment, which is beyond the ability of any single-modality imaging method. In this paper, we introduce a custom-made intrauterine dual-modality (OCT/ultrasound) endoscopic imaging system and achieve in vivo imaging of rabbit uteri, for the first time to our knowledge. The endometrial features of the injured uteri in both ultrasonic and OCT images are consistent with their corresponding pathology. The quantified parameters ...

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    7. Cervical optical coherence tomography image classification based on contrastive self-supervised texture learning

      Cervical optical coherence tomography image classification based on contrastive self-supervised texture learning

      Background: Cervical cancer seriously affects the health of the female reproductive system. Optical coherence tomography (OCT) emerged as a non-invasive, high-resolution imaging technology for cervical disease detection. However, OCT image annotation is knowledge-intensive and time-consuming, which impedes the training process of deep-learning-based classification models. Purpose: This study aims to develop a computer-aided diagnosis (CADx) approach to classifying in-vivo cervical OCT images based on self-supervised learning. Methods: In addition to high-level semantic features extracted by a convolutional neural network (CNN), the proposed CADx approach designs a contrastive texture learning (CTL) strategy to leverage unlabeled cervical OCT images' texture features. We conducted ...

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    8. Study on the application and imaging characteristics of optical coherence tomography in vulva lesions

      Study on the application and imaging characteristics of optical coherence tomography in vulva lesions

      In this study, a prospective study was conducted by using optical coherence tomography (OCT) in the in vivo detection of vulvar diseases. The clinical efficacy of the OCT we investigated in the detection of vulvar diseases, and the characteristics of the OCT images were defined. Overall, this study recruited 63 patients undergoing the colposcopy for vulvar lesions in three Chinese hospitals from December 20th, 2018 and September 24th, 2019. The colposcopy and the OCT examination were performed successively, and the OCT images were compared with the relevant tissue sections to characterize different lesions. The OCT diagnoses where categorized into 7 ...

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    9. Ovarian cancer detection using optical coherence tomography and convolutional neural networks

      Ovarian cancer detection using optical coherence tomography and convolutional neural networks

      Ovarian cancer has the sixth-largest fatality rate in the United States among all cancers. A non-surgical assay capable of detecting ovarian cancer with acceptable sensitivity and specificity has yet to be developed. However, such a discovery would profoundly impact the pace of the treatment and improvement to patients’ quality of life. Achieving such a solution requires high-quality imaging, image processing, and machine learning to support an acceptably robust automated diagnosis. In this work, we propose an automated framework that learns to identify ovarian cancer in transgenic mice from optical coherence tomography (OCT) recordings. Classification is accomplished using a neural network ...

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    10. Researchers pilot 'itty bitty' device for earlier ovarian cancer detection

      Researchers pilot 'itty bitty' device for earlier ovarian cancer detection

      Due to a lack of effective screening and diagnostic tools, more than three-fourths of ovarian cancer cases are not found until the cancer is in an advanced stage. As a result, fewer than half of all women with ovarian cancer survive more than five years after diagnosis. Jennifer Barton , director of the University of Arizona BIO5 Institute and Thomas R. Brown Distinguished Chair in Biomedical Engineering , has spent years developing a device small enough to image the fallopian tubes – narrow ducts connecting the uterus to the ovaries – and search for signs of early-stage cancer. Dr. John Heusinkveld has now used ...

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    11. Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Glannaventa Receives a 2021 NIH NCI SBIR Grant for $399,331 for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. The principal investigator is John Black. Below is a summary of the proposed work. This year, over 22,000 women in the U.S. will be diagnosed with ovarian cancer (OvCa), and ~14,000 will die from this disease. Approximately 9,000 of these deaths occur from high-grade serous epithelial cancer (HGSC) primarily because of our inability to detect the disease in its early stages. OvCa accounts for 2.5% of all ...

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    12. University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      University of California at Irvine Receives a 2021 NIH Grant for $1,946,945 for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Genitourinary Syndrome of Menopause (GSM) affects up to 50% of women and negatively affects their quality of life with regard to general health and sexual function. Hormone therapy is the most commonly performed procedure to supplement the natural estrogen, but health risk associated with long-term therapy exists. Recently, an alternative therapy has been proposed using fractional CO2 micro- ablation ...

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    13. Endometrium optical coherence tomography (OCT) and histomorphometry in implantation window and their relationships with reproductive failure and implantation outcome

      Endometrium optical coherence tomography (OCT) and histomorphometry in implantation window and their relationships with reproductive failure and implantation outcome

      Study question How do endometrium OCT image characteristics during peri-implantation window correlate with histomorphometry and associate with implantation outcomes in women with reproductive failure? Summary answer Endometrium OCT intensity correlated with stromal cell density and gland size. Endometrium with recurrent implantation failure had low OCT intensity but reversed in successful implantation. What is known already OCT is a non-invasive imaging technique using low energy near-infrared light to capture micrometer-scale resolution images from optical scattering media. An image produced by OCT resembles tissue architecture observed in histology, so OCT imaging has been regarded as “optical biopsy”. Our previous findings demonstrated OCT ...

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    14. Pelvic Organs Prolapse Treatment Using Neodymium Laser

      Pelvic Organs Prolapse Treatment Using Neodymium Laser

      The aim of this prospective study is investigation of efficiency and safety of medical device "Magic Max" for preoperative treatment of pelvic organs prolapse I-II degree of severity. To assess the condition of the vaginal walls and vulva before and after laser treatment, the following methods will be used: ultrasonography with Doppler ultrasonography, vaginal health index, histological examination, immunohistochemical examination, optical coherence tomography (OCT) (elastography). Pelvic Floor Distress Inventory Questionnaire (PFDI-20), The Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF), Pelvic Floor Impact Questionnaire (PFIQ-7) will be used to collect feedback on ...

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    15. Multidimensional Data Processing for Optical Coherence Tomography Imaging (Thesis)

      Multidimensional Data Processing for Optical Coherence Tomography Imaging (Thesis)

      Optical Coherence Tomography (OCT) is a medical imaging technique which distinguishes itself by acquiring microscopic resolution images in-vivo at millimeter scale fields of view. The resulting in images are not only high-resolution, but often multi-dimensional to capture 3-D biological structures or temporal processes. The nature of multi-dimensional data presents a unique set of challenges to the OCT user that include acquiring, storing, and handling very large datasets, visualizing and understanding the data, and processing and analyzing the data. In this dissertation, three of these challenges are explored in depth: sub-resolution temporal analysis, 3-D modeling of fiber structures, and compressed sensing ...

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    16. In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

      In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

      Developmental biologists have always relied on imaging to shed light on dynamic cellular events. However, processes such as mammalian fertilization and embryogenesis are generally inaccessible for direct imaging. In consequence, how the oviduct (fallopian tube) facilitates the transport of gametes and preimplantation embryos continues to be unanswered. Here we present a combination of intravital window and optical coherence tomography for dynamic, volumetric, in vivo imaging of oocytes and embryos as they are transported through the mouse oviduct. We observed location-dependent circling, oscillating, and long-distance bi-directional movements of oocytes and embryos that suggest regulatory mechanisms driving transport and question established views ...

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    17. The unexpected journey of the egg and the embryo through the fallopian tube

      The unexpected journey of the egg and the embryo through the fallopian tube

      The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging. Looking to shed new light on the dynamics of the eggs prior to fertilization and embryo transport preceding implantation, researchers at Baylor College of Medicine and Stevens Institute of Technology developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.

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    18. Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models

      Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models

      Stevens Institute of Technology Receives a 2021 NIH Grant for $182,953 for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models. The principal investigator is Shang Wang. Below is a summary of the proposed work. Tubal ectopic pregnancy (tEP) is a life-threatening reproductive disorder affecting nearly 2% of pregnancies in developed countries. The etiology of tEP is far from resolved, leaving no way to design preventive measures and few strategies for early diagnosis. Investigating how a tEP forms and develops has been extremely difficult. Because it is unethical to access human oviduct (fallopian tube) during healthy pregnancies ...

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    19. Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

      Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

      In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were ...

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    20. Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

      Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

      We have recently developed and optimized a vaginal Optical Coherence tomography /angiography endoscopy imaging system. This technology is able to obtain a comprehensive image of the vaginal epithelium, blood vessels, and lamina propria. The primary focus of this study is establishing the Optical Coherence Tomography system's capability of capturing vaginal changes that occur before and after menopause, as well as before and after treatment with fractional-CO2 laser therapy.

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      Mentions: UC Irvine
    21. Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge of tissue-specific fiber architecture. This study explores image processing, enhancement, segmentation, and detection algorithms to map 3-D collagen fiber architecture from OCT images alone. 3-D fiber mapping, histogram analysis, and 3-D tractography revealed fiber groupings and macro-organization previously unseen in uterine tissue samples. We applied our method on centimeter-scale mosaic OCT volumes of uterine tissue blocks from pregnant and non-pregnant specimens revealing a complex, patient-specific network of fibrous collagen and myocyte bundles.

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    22. Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography

      Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography

      To preserve the fertility of young female cancer patients, ovarian tissue cryopreservation and transplantation have been investigated as next-generation reproductive medical technologies. Non-invasive visualization of follicles in ovarian tissue and cryopreservation of higher density tissue is essential for effective transplantation. We proposed the use of optical coherence tomography (OCT) that can noninvasively visualize the internal structure of the ovarian tissue. However, a method for quantifying cell density has not yet been established because of the lack of available techniques to visualize follicles noninvasively. We proposed the use of a convolutional neural network (CNN) to extract small features from medical images ...

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    23. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Optical Vaginal Biopsy Using Optical Coherence Tomography

      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO 2 laser therapy were assessed ...

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      Mentions: UC Irvine
    24. Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

      Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

      An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young’s modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young’s modulus can be accurately estimated using this scheme. We then measured the Young’s modulus of rodent cervical tissues acquired at different gestational ages ...

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    1-24 of 137 1 2 3 4 5 6 »
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