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Optical coherence tomography as approach for the minimal invasive localization of the germinal disc in ovo before chicken sexing
Explore Article SPIE Digital Library (May 18 2010)
In most industrial states a huge amount of newly hatched male layer chickens are usually killed immediately after hatching by maceration or gassing. The reason for killing most of the male chickens of egg producing races is their slow growth rate compared to races specialized on meat production. When the egg has been laid, the egg contains already a small disc of cells on the surface of the yolk known as the blastoderm. This region is about 4 - 5 mm in diameter and contains the information whether the chick becomes male or female and hence allows sexing of the ...
Comment on Article Mentions: Edmund Koch Dresden University of Technology
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The Embryonic Heart: Imaging Life as it Happens - University of Houston Professor Captures Video of Heart Before it Begins to Beat (Video Snippet)
Explore Article Optical Coherence Tomography News (Apr 2 2010)
Imagine being able to image life as it happens by capturing video of the embryonic heart before it begins beating. A professor at the University of Houston, in collaboration with scientists at Baylor College of Medicine, is doing just that. Kirill Larin, assistant professor of biomedical engineering in the Cullen College of Engineering at UH, and his colleagues in the Texas Medical Center are documenting the formation of the mammalian heart through a high-resolution, non-invasive imaging device, providing perhaps the best live imagery taken of the vital organ. “Everything we know about early development of the heart and formation of ...
Comment on Article Mentions: Kirill V. Larin Baylor College of Medicine University of Houston
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Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand
Explore Article Circulation Research (Mar 7 2010)
Rationale: Drosophila has been recognized as a model to study human cardiac diseases. Objective: Despite these findings, and the wealth of tools that are available to the fly community, forward genetic screens for adult heart phenotypes have been rarely performed because of the difficulty in accurately measuring cardiac function in adult Drosophila. Methods and Results: Using optical coherence tomography to obtain real-time analysis of cardiac function in awake Drosophila, we performed a genomic deficiency screen in adult flies. Based on multiple complementary approaches, we identified CG31665 as a novel gene causing dilated cardiomyopathy. CG31665, which we name weary (wry), has ...
Comment on Article Mentions: Duke University Bioptigen
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Focusing light through living tissue
Explore Article SPIE Digital Library (Feb 19 2010)
Tissues such as skin, fat or cuticle are non-transparent because inhomogeneities in the tissue scatter light. We demonstrate experimentally that light can be focused through turbid layers of living tissue, in spite of scattering. Our method is based on the fact that coherent light forms an interference pattern, even after hundreds of scattering events. By spatially shaping the wavefront of the incident laser beam, this interference pattern was modified to make the scattered light converge to a focus. In contrast to earlier experiments, where light was focused through solid objects, we focused light through living pupae of Drosophila melanogaster. We ...
Comment on Article Mentions: University of Zurich
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Minimal invasive localization of the germinal disc in ovo for subsequent chicken sexing using optical coherence tomography
Explore Article SPIE Digital Library (Feb 19 2010)
Reason for using optical coherence tomography (OCT) to locate the germinal disc is the questionable and ethically alarming killing of male layer chickens because for the layer line only the females are necessary. To avoid this and to protect the animal rights, the sex of the fertilized chicken egg has to be determined as early as possible in the unincubated state. Because the information whether the chick becomes male or female can be found in the germinal disc an accurate localization for sexing is essential. The germinal disc is located somewhere on top of the yolk and has a diameter ...
Comment on Article Mentions: Edmund Koch Julia Walther Dresden University of Technology
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Gabor-based fusion technique for Optical Coherence Microscopy
Explore Article opticsinfobase.org (Feb 4 2010)
We recently reported on an Optical Coherence Microscopy technique, whose innovation intrinsically builds on a recently reported - 2 μm invariant lateral resolution by design throughout a 2 mm cubic full-field of view - liquid-lens-based dynamic focusing optical probe [Murali et al.,Optics Letters 34, 145-147, 2009]. We shall report in this paper on the image acquisition enabled by this optical probe when combined with an automatic data fusion method developed and described here to produce an in-focus high resolution image throughout the imaging depth of the sample. An African frog tadpole (Xenopus laevis) was imaged with the novel probe and ...
Comment on Article Mentions: Kevin P. Thompson Panomsak Meemon Supraja Murali
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Sub-cellular resolution imaging with Gabor domain optical coherence microscopy
Explore Article SPIE Digital Library (Jan 25 2010)
Optical Coherence Microscopy (OCM) utilizes a high NA microscope objective in the sample arm to achieve an axially and laterally high resolution OCT image. An increase in NA, however, leads to a dramatically decreased depth of focus (DOF), and hence shortens the imaging depth range so that high lateral resolution is maintained only within a small depth region around the focal plane. One solution to increase the depth of imaging while keeping a high lateral resolution is dynamic-focusing. Utilizing the voltage controlled refocus capability of a liquid lens, we have recently presented a solution for invariant high resolution imaging using ...
Comment on Article Mentions: University of Rochester Kye-Sung Lee Jannick P. Rolland
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Fourier Domain Optical Coherence Tomography as a Noninvasive Means for In Vivo Detection of Retinal Degeneration in Xenopus laevis Tadpoles
Explore Article iovs.org (Jan 19 2010)
ose. To determine the efficacy of Fourier domain optical coherence tomography (FD-OCT) as a noninvasive, nonlethal method for detecting in vivo, pathologic signs of retinal degeneration in Xenopus laevis larvae. Methods. A prototype OCT system using FD detection customized for tadpole imaging was used to noninvasively obtain retinal scans in two different transgenic X. laevis models of retinal degeneration. FD-OCT retinal scans were compared with laser scanning confocal micrographs of histologic sections of the same eye. Retinal thickness was measured in the histologic micrographs and compared with in vivo measurements acquired with FD-OCT. Results. In vivo retinal images of X. ...Comment on Article Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University
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Development of a high speed spectral domain optical coherence tomography system at 835 nm
Explore Article SPIE Digital Library (Dec 1 2009)
We develop a high speed multi-functional spectral domain (SD-OCT) system, using a broadband light source centered at 835nm and a custom-built spectrometer with a spectral resolution of 0.0674nm. After precise spectral calibration of the spectrometer, non-uniform discrete Fourier transform (NDFT) of the acquired spectral data is adopted for image reconstruction. In vivo imaging of human finger from volunteer at A-scan rate of 29 kHz with different reconstruction methods reveal that with the NDFT method, improved sensitivity fall-off especially at large depth is achieved in contrast to the conventional discrete Fourier transform (DFT) with interpolation method. And the phase information of ...Comment on Article Mentions: Zhejiang University
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Multiple-cardiac-cycle noise reduction in dynamic optical coherence tomography of the embryonic heart and vasculature
Explore Article opticsinfobase.org (Nov 20 2009)
Recent progress in optical coherence tomography (OCT) allows imaging dynamic structures and fluid flow within scattering tissue, such as the beating heart and blood flow in mouse embryos. Accurate representation and analysis of these dynamic behaviors require reducing the noise of the acquired data. Although noise can be reduced by averaging multiple neighboring pixels in space or time, such operations reduce the effective spatial or temporal resolution that can be achieved. We have developed a computational postprocessing technique to restore image sequences of cyclically moving structures that preserves frame rate and spatial resolution. The signal-to-noise ratio (SNR) is improved by ...
Comment on Article Mentions: Kirill V. Larin Baylor College of Medicine University of Houston
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In vivo imaging of the cyclic changes in cross-sectional shape of the ventricular segment of pulsating embryonic chick hearts at stages 14 to 17: A contribution to the understanding of the ontogenesis of cardiac pumping function
Explore Article www3.interscience.wiley.com (Nov 20 2009)
The cardiac cycle-related deformations of tubular embryonic hearts were traditionally described as concentric narrowing and widening of a tube of circular cross-section. Using optical coherence tomography (OCT), we have recently shown that, during the cardiac cycle, only the myocardial tube undergoes concentric narrowing and widening while the endocardial tube undergoes eccentric narrowing and widening, having an elliptic cross-section at end-diastole and a slit-shaped cross-section at end-systole. Due to technical limitations, these analyses were confined to early stages of ventricular development (chick embryos, stages 10-13). Using a modified OCT-system, we now document, for the first time, the cyclic changes in cross-sectional ...Comment on Article Mentions: Technical University of Denmark Lars Thrane
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Manual-scanning optical coherence tomography probe based on position tracking
Explore Article opticsinfobase.org (Oct 27 2009)
A method based on position tracking to reconstruct images for a manual-scanning optical coherence tomography (OCT) probe is proposed and implemented. The method employs several feature points on a hand-held probe and a camera to track the device’s pose. The continuous device poses tracking, and the collected OCT depth scans can then be combined to render OCT images. The tracking accuracy of the system was characterized to be about 6 um along two axes and 19 um along the third. A phantom target was used to validate the method. In addition, we report OCT images of a 54-stage Xenopus laevis ...
Comment on Article Mentions: Jigang Wu Jian Ren Emily J. McDowell
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A 3D Video of the Embryonic Heartbeat
Explore Article Technology Review (Oct 22 2009)
Researchers are using a new imaging technique to study the development of the mammalian heart. One percent of infants in the United States are born with cardiovascular abnormalities. The developmental processes that lead to these congenital problems aren't visible in ultrasound scans, and the lack of tools for imaging mammalian development non-invasively at high resolution has hindered researchers' attempts to understand these processes. In the hopes of providing insights into how these developmental problems might be prevented, researchers at the University of Houston have developed an imaging system they're using to take 3D video of the mammalian heart as it ...Comment on Article Mentions: Kirill V. Larin University of Houston
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Live imaging of rat embryos with Doppler swept-source optical coherence tomography
Explore Article Scitation (Oct 1 2009)
The rat has long been considered an excellent system to study mammalian embryonic cardiovascular physiology, but has lacked the extensive genetic tools available in the mouse to be able to create single gene mutations. However, the recent establishment of rat embryonic stem cell lines facilitates the generation of new models in the rat embryo to link changes in physiology with altered gene function to define the underlying mechanisms behind congenital cardiovascular birth defects. Along with the ability to create new rat genotypes there is a strong need for tools to analyze phenotypes with high spatial and temporal resolution. Doppler OCT ...Comment on Article Mentions: Kirill V. Larin University of Houston
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Serial Examination of an Inducible and Reversible Dilated Cardiomyopathy in Individual Adult Drosophila
Explore Article PLoS ONE (Sep 24 2009)
Recent work has demonstrated that Drosophila can be used as a model of dilated cardiomyopathy, defined as an enlarged cardiac chamber at end-diastole when the heart is fully relaxed and having an impaired systolic function when the heart is fully contracted. Gene mutations that cause cardiac dysfunction in adult Drosophila can result from abnormalities in cardiac development or alterations in post-developmental heart function. To clarify the contribution of transgene expression to post-developmental cardiac abnormalities, we applied strategies to examine the temporal and spacial effects of transgene expression on cardiac function. We engineered transgenic Drosophila based on the well-characterized temperature-sensitive Gal80 ...Comment on Article Mentions: Duke University Bioptigen
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Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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