Category: Clinical Trials

1. OCT Companies in the News

   (9 articles) Carl Zeiss Meditec

   (4 articles) LightLab Imaging

   (3 articles) Boston Scientific

   (2 articles) Topcon Medical Systems

   (2 articles) Heidelberg Engineering

   (2 articles) Optovue

   (1 articles) Nidek

   (1 articles) Imalux

2. OCT Products in the News

   (6 articles) Zeiss Cirrus HD-OCT

   (3 articles) Zeiss Stratus OCT

   (2 articles) Heidelberg Spectralis

   (2 articles) Topcon 3D OCT-1000

   (2 articles) Optovue RTVue-100

   (1 articles) Lightlab M3 Imaging Console

   (1 articles) Imalux Niris

   (1 articles) Lightlab ImageWire

3. Organizations in the News

   (4 articles) UC Irvine

   (3 articles) Yonsei University

   (3 articles) Ludwig Boltzmann Institute

   (3 articles) Case Western Reserve University

   (1 articles) Prince of Songkla University

   (1 articles) San Raffaele Scientfic Institute

   (1 articles) Center for Ophthalmic Optics and Lasers

   (1 articles) European Society of Cardiology

   (1 articles) University of Zurich

   (1 articles) UCSD

4. People in the News

   (3 articles) Giulio Guagliumi

   (2 articles) Matthew Brenner

   (1 articles) Kenichi Fujii

   (1 articles) Robert N. Weinreb

   (1 articles) Robert J. Noecker

   (1 articles) Mette Mogensen

   (1 articles) Hiroshi Ishikawa

   (1 articles) Gadi Wollstein

   (1 articles) Cynthia A. Toth

   (1 articles) Gary S. Mintz

1. Vessel Wall Response of the Bio-Active-stent and Everolimus-Eluting Stent Assessed By Optical Coherence Tomography (BASE-OCT)

   Explore Article Home - ClinicalTrials.gov (Mar 3 2010) Cardiology , Clinical Trials

   e purpose of the trial is to evaluate the completeness of struts coverage and vessel wall response (strut malapposition, neoin-timal formation) to the bio-active-stent (BAS) versus ever-olimus-eluting stent (EES) implanted for the treatment of the culprit lesion in acute coronary syndrome.
   

   Comment on Article

2. Endothelial Function After Drug-Eluting Stent (DES)

   Explore Article Home - ClinicalTrials.gov (Feb 22 2010) Cardiology , Clinical Trials

   The purpose of this study is to compare coronary endothelium function in patients with a zotarolimus-eluting versus a sirolimus-eluting or a everolimus-eluting stents with optical coherence tomography, vasoconstriction in response to acetylcholine, and coronary biomarker level.
   

   Comment on Article Mentions:   Kenichi Fujii

3. Comparison Between Foresee Home and Optical Coherence Tomography (OCT) Visual Field Defects in Patients With Choroidal Neovascularization (CNV)

   Explore Article Home - ClinicalTrials.gov (Feb 22 2010) Ophthalmology , Clinical Trials

   The Foresee Home is used in the recent years to detect age-related macular degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal neovascularization (CNV). The Foresee Home demonstrates a high level of sensitivity and specificity as to the different stages of AMD including newly diagnosed or early detection of CNV. The OCT may be use as well to identify choroidal neovascularization (CNV). Comparison between the two methods will allow better understanding of both devices. The Foresee Home can use as an assessment tool for the progression and success ...
   

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4. The Performances of Spectral Domain Optical Coherence Tomography (OCT) for Distinguishing Glaucomatous Eyes

   Explore Article Home - ClinicalTrials.gov (Feb 10 2010) Ophthalmology , Clinical Trials

   The purpose of this study is to evaluate performances of each parameters of spectral domain (Cirrus) optical coherence tomography for distinguishing between normal eyes, glaucoma suspect and glaucomatous eyes
   

   Comment on Article Mentions:   Prince of Songkla University   Carl Zeiss Meditec   Zeiss Cirrus HD-OCT

5. Staccato: Stent sTrut Apposition and Coverage in Coronary ArTeries: an Optical Coherence Tomography (OCT) Study

   Explore Article Home - ClinicalTrials.gov (Feb 8 2010) Cardiology , Clinical Trials

   Assessment of vessel healing after DES implantation in STEMI, NSTEMI and stable/unstable angina patients: a randomized comparison between everolimus and biolimus A9-eluting stents: an optical coherence tomography (OCT) and intravascular ultrasound-tissue characterisation (IVUS-TC) study. Plaque characterisation substudy: Assessment of culprit lesions in different subsets of patients (STEMI, NSTEMI and stable/unstable angina) by use of optical coherence tomography (OCT) and intravascular ultrasound tissue characterisation (IVUS-TC).
   

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6. Seduce :Safety and Efficacy of a Drug elUting Balloon in Coronary Artery rEstenosis:an Optical Coherence Tomography (OCT) Study

   Explore Article Home - ClinicalTrials.gov (Feb 8 2010) Cardiology , Clinical Trials

   Different healing responses after treatment of bare metal stent restenosis with implantation of an everolimus-eluting Xience V stent (Abbott Vascular) versus use of a paclitaxel-eluting SeQuent Please balloon (BBraun): an optical coherence tomography study. A prospective, single-centre, randomized clinical trial with clinical, angiographic and OCT follow-up at 9 months.
   

   Comment on Article

7. Optical Coherence Tomography Evaluation of a Biodegradable Polymer-based Drug-eluting Stent (PONTINA)

   Explore Article Home - ClinicalTrials.gov (Feb 1 2010) Cardiology , Clinical Trials

   PONTINA aims at assessing by optical coherence tomography the neointimal coverage of the biodegradable polymer-based Biolimus A9-eluting stent (Biomatrix stent) after full drug elution and polymer biodegradation (6 months), at one month after this time-point (7 months) and, as a comparator, of its bare metal stent counterpart (Gazelle stent) at 1 month after implantation.
   

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8. Intimal Hyperplasia Evaluated by Optical Coherence Tomography (OCT) in de Novo Coronary Lesions Treated by Drug-Eluting Balloon and Bare-Metal Stent

   Explore Article Home - ClinicalTrials.gov (Jan 26 2010) Cardiology , Clinical Trials

   Restenosis due to neointimal hyperplasia causes repeat target vessel revascularization in a relevant number of patients undergoing percutaneous coronary interventions (PCI). Drug-eluting stents (DES) are currently adopted to reduce the rate of restenosis; however, they may increase risk of stent thrombosis. Experimental data and first clinical experiences showed that inhibition of neointimal hyperplasia may be obtained by local administration of anti-proliferative drugs (like paclitaxel) loaded on the surface of angioplasty balloons. Data on the efficacy of novel coronary drug-eluting balloons (DEBs) are lacking. Aims of this open label prospective, randomized trial is to evaluate neointimal hyperplasia in patients undergoing bare-metal ...
   

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9. Optical Coherence Tomography to Evaluate Paclitaxel-Eluting Balloons and Everolimus-Eluting Coronary Stents

   Explore Article Home - ClinicalTrials.gov (Jan 25 2010) Cardiology , Clinical Trials

   Background: Safety concerns regarding use of drug eluting stent systems (DES) are related mostly to late stent thrombosis, which is facilitated by incomplete stent endothelial coverage. Specific information about time course and amount of endothelial strut coverage of different DES is required, in order to further refine the concept of antiplatelet therapy after DES implantation. Optical coherence tomography (OCT) is emerging as a new gold standard for endovascular imaging of stents, atherosclerosis progression, vulnerable plaque and neointimal proliferation. Very limited OCT data about endothelial coverage of DES are currently available. Aim of this study is a comparative evaluation of XIENCE ...
   

   Comment on Article Mentions:   Boston Scientific

10. Rationale and study design of the Oister trial: Optical coherence tomography evaluation of stent struts re-endothelializatIon in patients with non-ST-elevation acute coronary syndromes - a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-

    Explore Article LWW Online (Jan 20 2010) Cardiology , Clinical Trials

    Rationale and study design of the OISTER trial: Optical coherence tomography evaluation of stent struts re-endothelializatIon in patients with non-ST-elevation acute coronary syndromes - a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-eluting stent implantation.
    

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11. Optical Coherence Tomography: An Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer

    Explore Article Home - ClinicalTrials.gov (Dec 11 2009) Bronchoscopy , Oncology , Clinical Trials

    Optical coherence tomography will be a feasible adjunct to flexible bronchoscopy, and provide images with good sensitivity and specificity to determine the presence of endobronchial malignancies. OCT could become a powerful tool in diagnostic pulmonary medicine, not only in the early recognition of lung cancer, but also in the evaluation and monitoring of microstructures in the lower respiratory tract that are affected by other inflammatory or invasive disease processes. Initially, OCT could be used to guide the location of biopsies which would likely provide increased specificity to traditional bronchoscopy. However, if the sensitivity and specificity of OCT images are comparable ...
    

    Comment on Article Mentions:   Food and Drug Administration

12. Analysis of the Effect of Intravitreal Dexamethasone Injection on Diabetic Macular Edema After Cataract Surgery (IDDMECS)

    Explore Article Home - ClinicalTrials.gov (Dec 9 2009) Ophthalmology , Clinical Trials

    Macular Edema (Swelling of a particular site of the retina) can become a significant problem for Diabetics undergoing Cataract surgery. And a significant number of people who undergo Cataract surgery each year are diabetics. And when you multiply these two factors together you are left with a significant number of people who do not gain as much vision as their peers. Diabetics who develop Macular Edema actually can loose some vision after surgery and when you follow them up, they don't gain as much vision. This Study aims to prevent such an event from happening and therefore allow Diabetics to ...
    

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13. An Age-Stratified Data Collection Study in Adult Males and Females, Ages 18 and Above to Establish a Normative Database Using the 3D Optical Coherence Tomography 3D OCT-1000 Mark II

    Explore Article Home - ClinicalTrials.gov (Dec 8 2009) Ophthalmology , Clinical Trials

    To collect three dimensional retinal measurements of the optic disc and the macula lutea on healthy normal subjects using the 3D OCT-1000 Mark II for the purpose of developing a normative database that is stratified by age.
    

    Comment on Article Mentions:   Topcon Medical Systems   Topcon 3D OCT-1000   UCSD

14. Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution OCT

    Explore Article Home - ClinicalTrials.gov (Dec 2 2009) Neurology , Ophthalmology , Clinical Trials

    Evaluation of Macular and Retinal Nerve Fiber Layer Thickness Measurements for Detection of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Optical Coherence Tomography.
    

    Comment on Article Mentions:   University of São Paulo

15. Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography (OCT) Combined With Intravascular Ultrasound (IVUS)

    Explore Article Home - ClinicalTrials.gov (Dec 1 2009) Cardiology , Clinical Trials

    Many trials suggested that lipid lowering therapy could significantly reduce cardiovascular events. Enhancing stability of vulnerable plaque is probably the main reason by which statins reduce adverse coronary events. The size of lipid core and the fibrous cap thickness (FCT) are the major determinants of plaque vulnerability. So, it is very important to accurately evaluate changes in plaque after stains therapy. Previous reports suggested that intensive lipid lowering therapy provide more significantly clinical benefit compared with moderate lipid lowering therapy.Such benefit may contribute to the changes in following parameters: FCT, lipid arc(quadrants), TCFA, macrophage, plaque disruption, and thrombus measured by ...
    

    Comment on Article Mentions:   LightLab Imaging

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