Articles in category: Clinical Trials

1. Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults

   Explore Home - ClinicalTrials.gov Jul 18 2018 Ophthalmology , Clinical Trials

   

   Optical coherence tomography angiography (OCTA) is a software upgrade on conventional spectral-domain or swept-source optical coherence tomography devices that enables non-invasive, dye-free, three dimensional analysis of the retinal vessels. Vessel density is a very important parameter almost in all retinal disorders. In the recent past, automated quantification software was built into some OCTA devices which can automatically calculate the retinal vessel density as well. In this study two semi-manual techniques are used in order to analyze the vessel density of healthy subjects' OCTA images. Vessel density is also measured with a new automated quantification program, and results of the three ...

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   Mentions: Carl Zeiss Meditec Semmelweis University

2. Visual Acuity and Optical Coherence Tomography One Year After Peeling of Epiretinal Membranes

   Explore Home - ClinicalTrials.gov Jul 11 2018 Ophthalmology , Clinical Trials

   

   Improvement in visual acuity and retinal anatomy one year after surgery is assessed and compared to data preoperative and 3 months after surgery

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   Mentions: Oliver Findl

3. Optical Coherence Tomography Compared With Intravascular Ultrasound to Guide High-speed Rotational Before Stent Implantation in the Treatment of Moderate-to-severe Calcified Lesion in Coronary Artery

   Explore Home - ClinicalTrials.gov Jul 2 2018 Cardiology , Clinical Trials

   

   This study is a prospective, multi-center, randomized controlled clinical trial, aims to assess the safety and effectiveness of Optical Coherence Tomography or Intravascular Ultrasound to guide high-speed rotational before Firehawk stent implantation , and compared with angiography guided stent implantation in the treatment of moderate-to-severe calcified lesion in coronary artery.

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4. Multimodal Optical Imaging for Pretreatment Evaluation for Cutaneous Microparticle Delivery

   Explore Home - ClinicalTrials.gov Jun 29 2018 Dermatology , Microscopy , Clinical Trials

   

   Brief Summary: The purpose of this study is to investigate how pretreatment with a topical medication for acne affects application and delivery of gold microparticles to the skin in acne patients. In addition, the investigators want to investigate the biodistribution of gold microparticles in pretreated skin and compare this with the biodistribution of untreated skin using the non-invasive imaging techniques optical coherence tomography and reflectance confocal microscopy. Reflectance Confocal Microscopy (RCM) and Optical Coherence Tomography (OCT) are non-invasive imaging technologies allowing for imaging of the upper skin layers. Gold microparticles have been shown to have a contrast effect on the ...

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5. OCT Measures Predicting FFR

   Explore Home - ClinicalTrials.gov Jun 29 2018 Cardiology , Clinical Trials

   

   Background: the decision-making process of patients with angiographically-intermediate coronary lesions (ICL) is clinically challenging and may benefit from adjunctive invasive techniques. Fractional-flow-reserve (FFR) represents the gold standard to evaluate ICL but optical-coherence-tomography (OCT) is a novel, promising, high resolution coronary imaging technique. Objectives: Investigate the relation between OCT and FFR parameters in ICL and understand if OCT measures may predict FFR. Understand if OCT parameters may predict clinical outcome of patients with ICL not underwent revascularization on the bases of negative FFR. Study design: multicentre, international, individual patient's level data pooled analysis.

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6. Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry (NAVIGATOR)

   Explore Home - ClinicalTrials.gov Jun 27 2018 Cardiology , Clinical Trials

   

   With regard to the characteristics of spasm segment, had been clearly described by other invasive imaging methods including intravascular ultrasound and optical coherence tomography . However, there is potential risk during these invasive procedures, such as severe myocardial ischemia or fatal arrhythmia. Presently available imaging test for coronary artery disease in multi detector-row computed tomography angiography (MDCTA) evaluation has high diagnostic accuracy to evaluate coronary artery stenosis. However, previous report assessing imaging findings or diagnostic accuracy of MDCTA in patients with vasospastic angina (VSA) is lacking.

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7. Imaging of Coronary Plaques in Subjects Treated With Evolocumab

   Explore Home - ClinicalTrials.gov Jun 27 2018 Cardiology , Clinical Trials

   

   This study seeks to identify morphologic changes, such as increase in fibrous cap thickness (FCT), in atherosclerotic plaques associated with treatment with evolocumab and maximally tolerated statin therapy with or without additional lipid-modifying medication in patients presenting with non-ST-segment elevation (NSTE)-ACS using optical coherence tomography (OCT;primary, secondary, and exploratory endpoints) and intravascular ultrasound (IVUS; exploratory endpoints only)

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8. Study on STEMI Reperfusion Strategy Based on the Characterization of Criminal Lesions Stability

   Explore Home - ClinicalTrials.gov Jun 27 2018 Cardiology , Clinical Trials

   

   A randomized controlled study of whether stent implantation in STEMI patients with ≤70% coronary stenosis was designed. A total of 240 STEMI patients with coronary artery diameter stenosis ≤ 70% were randomly assigned to either an OCT-guided group or an angiography-guided group. OCT guidance group: Stent implantation or drug therapy is determined based on the stability of the culprit lesions by the OCT. Angiographic guide group: According to the results of coronary angiography, stent implantation or drug treatment was determined. Comparing two groups the implantation rate, the incidence of HF within one year, the incidence of MACE, and the safety end ...

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   Mentions: Harbin Medical University Bo Yu

9. Basal Cell Carcinomas Treated With Ablative Fractional Laser and Ingenol Mebutate

   Explore Home - ClinicalTrials.gov Jun 26 2018 Dermatology , Clinical Trials

   

   Brief Summary: A prospective clinical, uncontrolled, open-label, explorative phase 2a trial on patients with histologically-confirmed superficial and nodular basal cell carcinoma (BCC). The study assesses tolerability and tumor clearance after laser-assisted topical delivery of topical ingenol mebutate. Detailed Description: Patients will receive ablative fractional laser (AFXl)-assisted ingenol mebutate (IM) as a treatment for their cutaneous basal cell carcinoma (BCC). Treatment areas consisting of tumors and a 5 mm margin will undergo AFXl exposure (CO2 laser) followed by IM 0.015% or 0.05% under occlusion for 2-3 days. . local skin reactions are monitored at baseline (day1), day 3/4 ...

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10. Leveraging WeChat Social-Media and Messaging Platform to Increase Physical Activity in Chinese Glaucoma Patients

    Explore Home - ClinicalTrials.gov Jun 22 2018 Ophthalmology , Clinical Trials

    

    The positive effects of exercise on ocular health are known, but modern lifestyles have made it difficult to incorporate physical activity into the daily lives of the Chinese population. Recent studies suggest that exercise plays an important role in lowering intraocular pressure (IOP) by protecting retinal ganglion cells (RGCs) in glaucoma patients as well as other potential neuroprotective benefits. Increasing the amount of physical activity within the Chinese glaucoma population may have marked effects on health outcomes and coincides with the Chinese government's efforts to make exercise an urgent public health priority. There is a need for innovative, cost-effective ...

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    Mentions: Johns Hopkins University Wenzhou Medical College

11. The EXPLORE Study - The Use of Binocular OCT Imaging for the Assessment of Ocular Disease

    Explore Home - ClinicalTrials.gov Jun 12 2018 Ophthalmology , Clinical Trials

    

    Optical coherence tomography (OCT) is an imaging modality, first described in 1991, that provides cross-sectional images of the eye in a non-invasive manner. OCT is analogous to ultrasonography but measures the "echoes" of light waves rather than sound and, as a result, generates extremely high-resolution images (~5 μm axial resolution). Although OCT has already proven revolutionary in ophthalmology, current OCT systems are large, expensive, and require skilled personnel for image acquisition and interpretation. Furthermore, current OCT systems are limited to examination of specific regions of single eyes - for example, separate devices are typically required for anterior segment (e.g., cornea ...

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    Mentions: Pearse A. Keane

12. The Efficacy of Alirocumab for Thin-cap fIbroatheroma in Patients With Coronary Artery Disease Estimated by Optical Coherence Tomography

    Explore Home - ClinicalTrials.gov Jun 11 2018 Cardiology , Clinical Trials

    

    The purpose of this study is to show that alirocumab with statin therapy have a s tronger stabilizing effect on vulnerable plaque in coronary artery disease than statin alone administration. The investigators investigate to evaluate the efficacy of alirocumab for vulnerable plaque. The investigators enrolled the patient with standard statin therapy who were detected vulnerable plaque by optical coherence tomography, and categorized into two group; the patients with alirocumab and rosuvastatin were categorized alirocumab therapy group, and the patients with rosuvastatin alone were categorized standard statin therapy group. The investigators compare these two group for outcomes.

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    Mentions: Kobe University Graduate School of Medicine Hiromasa Otake

13. Focal Prostate Imaging With CLE and OCT (FPI)

    Explore Home - ClinicalTrials.gov May 22 2018 Urology , Clinical Trials

    

    The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging modalities with potential for in-vivo prostate imaging. The investigators anticipate that integrating focal imaging with MRI/TRUS fusion will further improve prostate cancer detection and provides a real-time histopathological threedimensional representation of the tumor lesions. This is an investigator-initiated, prospective in-vivo safety and feasibility study with transperineal template mapping biopsies (TTMB) and two focal imaging methods, CLE and OCT, in prostate tissue.

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    Mentions: Academic Medical Center at the University of Amsterdam Jean J. M. C. H. de la Rosette

14. OCT in Diagnosis of Irregular Corneas

    Explore Home - ClinicalTrials.gov Apr 25 2018 Ophthalmology , Clinical Trials

    

    This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: Develop an OCT-based system to classify and evaluate corneal-shape irregularities. Develop OCT metrics for more sensitive detection of keratoconus progression. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.

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    Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers

15. Evaluation of Imaging of Peripheral Arteries by Optical Coherence Tomography and Intravascular Ultrasound Imaging (SCAN)

    Explore Home - ClinicalTrials.gov Apr 15 2018 Cardiology , Clinical Trials

    

    A non inferiority trial to determine the capability of optical coherence tomography (OCT) imaging to show vessel morphology in comparison to imaging provided by intravascular ultrasound imaging (IVUS).

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    Mentions: Avinger

16. Diagnosis of Acquired Punctal Stenosis Using Anterior Segment Optical Coherence Tomography

    Explore Home - ClinicalTrials.gov Apr 14 2018 Ophthalmology , Clinical Trials

    

    To evaluate the lower puntum dimensions in cases of acquired punctal stenosis(APS), using anterior segment optical coherence tomography (AS-OCT).

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17. SOLEMN Study - Synergy Optical Coherence Tomography in Left Main PCI (SOLEMN)

    Explore Home - ClinicalTrials.gov Mar 23 2018 Cardiology , Clinical Trials

    

    Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main coronary artery stenosis. Protected LM PCI is considered standard of care in most centers. OCT allows for precise determination of stent placement, stent expansion and apposition. The pattern of vessel healing can be very precisely studied if immediate post-stent implantation OCT/IVUS data is compared to the 6-month post-PCI interval. While OCT cannot be optimally used for ostial lesion imaging, IVUS can be used to image ostial lesions/stent placement. Optimal and consistent vessel healing is particularly important in LM PCI where stent thrombosis is a potential complication ...

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    Mentions: Boston Scientific

18. Optical Coherence Tomography in Cerebral Amyloidosis

    Explore Home - ClinicalTrials.gov Mar 22 2018 Ophthalmology , Clinical Trials

    

    In this observational study, the investigators aim to evaluate whether changes in the retinal and choroidal circulation, as assessed by Optical Coherence Tomography (OCT) and the quantification of retinal amyloid deposits using auto-fluorescence and hyperspectral retinal imaging, are correlated with the degree and subtype of dementia and with the presence or absence of a positive amyloid scan. For this purpose, patients with established Alzheimer's Disease (AD) and Lewy Body Dementia (LBD), as well as amyloid positive and amyloid negative Mild Cognitive Impairment (MCI) and aged matched cognitively intact patients will be included in this cross-sectional study.

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19. Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition

    Explore Home - ClinicalTrials.gov Mar 15 2018 Ophthalmology , Clinical Trials

    

    ILM-flap transposition is a new surgical option in repair of macular holes, therefore one year outcomes are needed to better evaluate that method.

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    Mentions: Medical University of Vienna Oliver Findl

20. Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures

    Explore Home - ClinicalTrials.gov Mar 13 2018 Ophthalmology , Clinical Trials

    

    The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology (Wojtkowski, Kaluzny et al. 2012; Drexler, Liu et al. 2014). The technology allows for both noninvasive visualization of the morphology and measurement of functional parameters within ocular tissues to a depth of a few millimetres even in nontransparent media. Until now the resolution of commercially available OCT systems is, however, much lower than that provided by light microscopy. Recently, an ultrahigh-resolution OCT system was developed by our group providing resolutions of 1.7 and 17 µm in axial and ...

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    Mentions: Medical University of Vienna

21. Vitreo-papillary Traction as an Entity Identified by Optical Coherence Tomography (OCT)

    Explore Home - ClinicalTrials.gov Mar 10 2018 Ophthalmology , Clinical Trials

    

    In ophthalmology vitreo-macular adhesion, vitreo-macular traction and posterior vitreous detachment were recognized entities for a long time. On the other hand vitreo-papillary adhesion/ traction is a fairly new concept in ophthalmology that became known after the use of OCT in ophthalmology imaging. Reasons, effects and ways of treatment of vitreo-papillary traction will take some time to evolve. The case study in which this traction was documented was initiated by an observation of a persistent, tiny single retinal hemorrhage above the optic disc of an eye. The patient was completely asymptomatic because of the vitreo-papillary traction but the OCT documentation of ...

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22. OCT Pilot in Esophagus

    Explore Home - ClinicalTrials.gov Feb 16 2018 Gastroenterology , Clinical Trials

    

    This is a pilot study to test a newly developed optical coherence tomography (OCT) device to determine 1) whether adequate tissue contact can be attained to acquire high quality images, and 2) to identify if these images can discern whether the imaged tissue is squamous or Barrett's Esophagus (BE) epithelium.

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    Mentions: Adam Wax

23. Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age) (OCTAC)

    Explore Home - ClinicalTrials.gov Jan 17 2018 Ophthalmology , Clinical Trials

    

    Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.

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    Mentions: Bern University Hospital

24. Optical Coherence Tomography Versus Intravascular Ultrasound Guided Percutaneous Coronary Intervention (OCTIVUS)

    Explore Home - ClinicalTrials.gov Jan 11 2018 Cardiology , Clinical Trials

    

    This study is to establish the primary hypothesis that Optical coherence tomography-guided Percutaneous coronary intervention(OCT-guided PCi) is superior to Intravascular ultrasound guided Percutaneous coronary intervention(IVUS-guided PCI) regarding the target vessel failure at 1 year.

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Organizations in the News

1. (1 articles) Johns Hopkins University
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4. (1 articles) Semmelweis University

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