Clinical Trials -Optical Coherence Tomography News

Articles in category: Clinical Trials

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1. Optical Coherence Tomography to Improve Clinical Outcomes During Coronary Angioplasty
  
  Explore ClinicalTrials.gov Feb 12 2014 Cardiology , Clinical Trials
  
  Coronary artery stenting has evolved as an effective treatment for angina and involves stretching up narrowings within the heart arteries using a balloon (coronary angioplasty) before implanting a small metal scaffold (stent) to splint the artery open. It is imperative that stents are fully expanded when they are deployed. If not, then patients are exposed to the serious risk of a blood clot forming in the stent (stent thrombosis), or the stent renarrowing (restenosis). One fifth of patients experiencing stent thrombosis will die and 70% will suffer a heart attack. Restenosis is associated with recurrent angina and heart attacks. Arguably ...
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2. Comparison of the 3-month Strut Coverage After Coronary Stenting by Optical Coherence Tomography; Cilotax and DESyne
  
  Explore ClinicalTrials.gov Feb 7 2014 Cardiology , Clinical Trials
  
  We will compare the stent coverage at 3 months by optical coherence tomography (OCT) between the Cilotax and DESyne drug-eluting stents (DES). The extent of the strut uncoverage has not been evaluated yet for both the Cilotax and DESyne and we first sought to decide the reference intervals using 40 samples (total 44 patients for each group considering 10% drop-out rate) as the pilot study.
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  Mentions: Yonsei University
3. Optical Coherence Tomography as a Biomarker in Clinical Trials for Ophthalmology and Neurology (Book Chapter)
  
  Explore Home - Springer Jan 23 2014 Ophthalmology , Clinical Trials , Textbooks
  
  In the past, clinical trials in neuro-ophthalmology have focused upon functional endpoints including Snellen visual acuity and visual field testing, both of which may have significant test/retest variability because of their dependence upon subject alertness and cognitive function. The introduction of optical coherence tomography (OCT) into the practice of clinical ophthalmology has now extended into clinical trials in both ophthalmology and neurology. Recent advances in the resolution and reproducibility of spectral-domain OCT have now produced algorithms that measure the structural integrity of the optic nerve and retina. OCT is in vivo histopathology and the qualitative and quantitative metrics of ...
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4. Imaging Lens Deposits in Exfoliation Syndrome
  
  Explore ClinicalTrials.gov Jan 21 2014 Ophthalmology , Clinical Trials
  
  The purpose of this study is to use a special eye imaging technique, anterior segment optical coherence tomography (AS-OCT), to image the lens (the curved, transparent part of the eye that helps you to see clearly by directing images of light onto the back of your eye) and note any changes in exfoliation syndrome. Exfoliation syndrome is a common condition that has many ways of showing up in the eye, including the formation of deposits in the eye, shakiness of the lens that can complicate cataract surgery, and a higher chance of developing a type of glaucoma called exfoliation glaucoma ...
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  Mentions: Duke University
5. Evaluation of Choroidal Thickness During Pregnancy Using Enhanced Depth Imaging Optical Coherence Tomography
  
  Explore ClinicalTrials.gov Dec 18 2013 Ophthalmology , Clinical Trials
  
  The purpose of this study is to evaluate choroidal thickness and volume during the third trimester of pregnancy by comparison with a group of age-matched non-pregnant healthy group of women
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6. Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent and Platelet AggregatioN Studies In Patients With Stable Angina Managed as Elective Case
  
  Explore ClinicalTrials.gov Dec 12 2013 Cardiology , Clinical Trials
  
  To treat patients with stable coronary artery disease, elective percutaneous coronary intervention (PCI) will be performed with the use of an everolimus-eluting cobalt- chromium stent (everolimus-eluting stent: EES, Xience Prime, Xpedition), which is the current standard drug-eluting stent (DES). Vascular responses at the site of stent placement will be evaluated by optical coherence tomography (OCT) at 1 or 3 months and at 12 months after stent placement, along with observation of changes over time in the target vessel. The relationships between OCT findings and the time course of platelet aggregation and between OCT findings and the occurrence of major cardio- ...
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  Mentions: Toshiro Shinke Kobe University Graduate School of Medicine
7. Multicenter Randomized Comparison of Early Vascular Responses Between Multicenter Randomized Comparison of Early Vascular Responses Between Everolimus-eluting Cobalt-CHromium Stent ANd Identically DeSigned Bare-Metal Stent in Patients With Acute Myocardia
  
  Explore ClinicalTrials.gov Dec 12 2013 Cardiology , Clinical Trials
  
  To evaluate early vessel response between current standard drug-eluting stent and bare-metal stent in acute myocardial infarction (AMI) patients by optical coherence tomography (OCT).
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  Mentions: Iwate Medical University
8. Optical Coherence Tomography (OCT) Normative Data Collection Study
  
  Explore ClinicalTrials.gov Dec 11 2013 Ophthalmology , Clinical Trials
  
  This study is being initiated to create a normal database including measures of optic nerve head (ONH), peripapillary retinal nerve fiber layer (RNFL), and macula using the Heidelberg Spectralis OCT device.
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  Mentions: Heidelberg Engineering New York Eye and Ear Infirmary Jeffrey M. Liebmann
9. OCT in Retinal Vein Occlusions
  
  Explore ClinicalTrials.gov Nov 19 2013 Ophthalmology , Clinical Trials
  
  Retinal blood vessel disease encompasses a wide variety of vision-threatening conditions. Of these conditions, retinal vein occlusions are the most common. Vision loss can occur as a result of macular ischemia (loss of blood flow to the macula) or macular edema (fluid build-up at the macula). OCT is an imaging technology that can perform non-contact cross-sectional imaging of retinal and choroidal tissue structures in real time. It is similar to ultrasound imaging, except that OCT measures the intensity of reflected light rather than sound waves. The purpose of this study is to see if non-invasive OCT technology can changes due ...
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  Mentions: David Huang Oregon Health & Science University
10. OCT Reference Database
  
  Explore ClinicalTrials.gov Nov 11 2013 Ophthalmology , Clinical Trials
  
  Topcon 3D OCT-1 Maestro and 3D OCT-2000 Optical Coherence Tomography Systems: Reference Database Study
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  Mentions: Topcon Medical Systems Topcon 3D OCT-2000
11. Transform OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography
  
  Explore ClinicalTrials.gov Oct 24 2013 Cardiology , Clinical Trials
  
  First prospective randomized controlled study to evaluate in an 'all-comers' population with coronary artery disease whether treatment with a novel everolimus eluting stent (EES) with a biodegradable polymer is superior to a durable polymer zotarolimus eluting stent (ZES), with respect to the long term vascular response to treatment These data are important to ascertain the superiority of a new generation DES with bioabsorbable polymer coating to reduce the long term development of in-stent neoatherosclerosis.
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  Mentions: Giulio Guagliumi
12. Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT
  
  Explore ClinicalTrials.gov Oct 18 2013 Ophthalmology , Clinical Trials
  
  The aim of the trial is to evaluate the efficacy and safety of intravitreal injections of ranibizumab for the treatment of macular edema due to BRVO if the re-treatment regimen is guided by morphological macular changes detected by OCT compared to re-treatment according to SmPC defined re-treatment criteria (in case of increase of CRT and concomitant decrease of BCVA).
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  Mentions: University of Leipzig
13. Serial Evaluation of Drug-Eluting Stents Using OCT (STRUT-OCT)
  
  Explore ClinicalTrials.gov Oct 8 2013 Cardiology , Clinical Trials
  
  The study is proposed as a 48-patient randomized-controlled pilot study that will use Optical Coherence Tomography (OCT) imaging to compare stent strut coverage and malapposition of three second-generation Drug Eluting Stents (DES) [Xience EES (Abbott Vascular, Santa Clara, CA), Resolute Integrity ZES (Medtronic, Minneapolis, MN) and Promus Element EES (Boston Scientific, Natick, MA)] at 6 weeks post implantation. Study Hypothesis is that the rates of stent strut coverage and malapposition of the Xience EES, Promus EES and will be similar to each other and improved (higher rates of stent strut coverage and lower rates of malapposition) compared to the Resolute ...
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  Mentions: UT Southwestern Medical Center
14. Blood Vessel Patterns in Small Choroidal Tumors
  
  Explore ClinicalTrials.gov Sep 30 2013 Ophthalmology , Clinical Trials
  
  The purpose of this study is to see if mapping blood vessel patterns with optical coherence tomography (OCT) will help identify life-threatening choroidal tumors in their early stages and improve overall patient survival through early detection. Uveal melanomas are melanocytic tumors that arise in the pigmented tissues of the eye: the iris, ciliary body, and choroid. Iris melanomas rarely metastasize (spread to other tissues or organs). In contrast, uveal melanomas arising in the ciliary body and choroid are highly malignant (cancerous and invasive to other tissues or organs). Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening ...
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  Mentions: David Huang Oregon Health & Science University
15. Vascular Response to Brachytherapy Using Functional OCT
  
  Explore ClinicalTrials.gov Sep 30 2013 Oncology , Ophthalmology , Clinical Trials
  
  The purpose of this study is to learn how blood flows to tumors in patients treated with I-125 plaque brachytherapy for uveal melanoma. Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening cancer, and even eye-sparing therapy with radiation treatment often leads to significant loss of vision. Major challenges to providing care to patients with uveal melanoma include the inability to accurately predict long-term vision in an eye treated with radiation, due to a poor understanding of the nature of radiation retinopathy and optic neuropathy. Optical coherence tomography (OCT) is a commonly used ophthalmic imaging modality that ...
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  Mentions: David Huang Oregon Health & Science University
16. Rapid Inflation/Deflation Compared With Prolonged High-Pressure Balloon Inflation (INFLATION/DE)
  
  Explore ClinicalTrials.gov Sep 18 2013 Cardiology , Clinical Trials
  
  It is universally accepted that high-pressure balloon inflation is required to most effectively deploy a coronary balloon-expandable stent. However, there is not consensus nor are there any guidelines regarding the method of balloon inflation, particularly the duration of inflation. Underexpansion and strut malapposition after stent deployment are among the most powerful predictors for adverse vessel outcomes. High-pressure inflation for stent deployment is effective to optimally expand the stent, but unlike in vitro testing in air, there are poorly distensible plaque elements that may not instantaneously yield to the balloon pressure. However, these elements may ultimately yield to prolonged inflation. Most ...
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17. Evaluation of the Retina of Subjects Without Diabetes Mellitus and Subjects With Diabetes Mellitus Without Diabetic Retinopathy Using Optical Coherence Tomography
  
  Explore ClinicalTrials.gov Sep 17 2013 Ophthalmology , Clinical Trials
  
  The purpose of this study is to evaluate topographic features of the posterior pole of the eye in normal subjects as well as in subjects with diabetes mellitus but without diabetic retinopathy (DR) usingoptical coherence tomography (OCT). The investigators proposal is a novel study to determine retinal volume of normal and diabetic subjects without DR. Specifically, the investigators will establish a standardized reference range for retinal thickness and volume that will provide standards for OCT analysis of different clinical trials for retinal diseases.
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  Mentions: Johns Hopkins University Quan Dong Nguyen
18. Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR Des)
  
  Explore ClinicalTrials.gov Sep 7 2013 Cardiology , Clinical Trials
  
  The purpose of this study is to evaluate the differences of wall shear stress distribution among different types of drug-eluting stents and its impact on vessel healing evaluated by intravascular optical coherence tomography evaluation.
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  Mentions: Kobe University Graduate School of Medicine Hiromasa Otake
19. Novel Retinal Imaging Biomarkers in Early Alzheimer's Disease
  
  Explore ClinicalTrials.gov Sep 4 2013 Neurology , Ophthalmology , Clinical Trials
  
  The goal of this study is to create new retinal imaging processing software useful for the development of novel retinal biomarkers of cognitive impairment associated with Alzheimer's disease (AD).
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  Mentions: Duke University
20. Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis
  
  Explore ClinicalTrials.gov Aug 28 2013 Ophthalmology , Clinical Trials
  
  Conjunctivochalasis refers to loose redundant, non-edematous inferior conjunctiva that is situated between the globe and lower eyelid, and usually it occurs bilaterally. It has been reported to cause ocular discomfort, tear instability, alteration of tear spreading and subsequently dry eye, which is a common condition that affects vision and quality of life in patients. This condition has also been reported to be associated with aging and ocular surface inflammation. The assessment of conjunctivochalasis was traditionally based on silt lamp examination and this may be cumbersome and highly subjective. Only recently, researchers have advocated the use of imaging and more objective ...
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  Mentions: Optovue Carl Zeiss Meditec Zeiss Cirrus HD-OCT
21. Eye Pressure Lowering Surgery
  
  Explore ClinicalTrials.gov Aug 27 2013 Ophthalmology , Clinical Trials
  
  The purpose of this study is to determine if lowering the pressure inside the eye improves blood flow to the eye. Official Title: OBSERVATIONAL STUDY OF OCULAR BLOOD FLOW PRE- AND POST- TRABECULECTOMY SURGERY USING FUNCTIONAL AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY
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  Mentions: David Huang Oregon Health & Science University
22. Diabetes PRP and OCT
  
  Explore ClinicalTrials.gov Aug 21 2013 Ophthalmology , Clinical Trials , Velocimetry
  
  The purpose of this study is to evaluate the effectiveness of investigational Doppler Optical Coherence Tomography (OCT) and OCT angiography in the management of proliferative diabetic retinopathy (PDR - a leading cause of blindness in diabetic patients) before and after treatment. Angiography is the mapping of the blood vessels, and Doppler detects blood flow. PDR is due to poor oxygen circulation in smaller blood vessels in the back of the eye (retina), and is observed in 80% of people who have had diabetes for more than 10 years. This study will look at how blood flow to the eye is affected ...
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  Mentions: David Huang Oregon Health & Science University
23. Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis
  
  Explore ClinicalTrials.gov Aug 20 2013 Neurology , Ophthalmology , Clinical Trials
  
  Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness. A reduction of the RNFL thickness has been detected in several neurodegenerative diseases, such as multiple sclerosis, CADASIL and Alzheimer's disease. Different studies have reported RNFL changes also in Parkinson's disease (PD),a common neurodegenerative disease characterized by motor dysfunctions, originally described by James Parkinson in 1817. PD is characterized by selective dopaminergic neuronal cells loss, which may correlate with RNFL thinning. Previous studies on this subject, however, reported contradicting ...
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  Mentions: Wenzhou Medical College
24. Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study
  
  Explore ClinicalTrials.gov Aug 2 2013 Cardiology , Clinical Trials
  
  Subjects presenting with probable acute coronary syndromes scheduled for cardiac catheterization will be enrolled in this study. Consented subjects will be randomized to receive ticagrelor started with a loading dose immediately after enrollment versus receiving a loading dose of ticagrelor during cardiac catheterization after diagnostic angiography but prior to stenting. Optical coherence tomography (OCT) will be performed after stenting and the volume of thrombus within the new stent will be measured and compared between the groups.
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Massachusetts General Hospital OCT Registry
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