1. Articles in category: Clinical Trials

    1-24 of 500 1 2 3 4 ... 19 20 21 »

    1. Effect of Evolocumab on Coronary Plaque Characteristics

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Effect of Evolocumab on Coronary Plaque Characteristics

      The aim of the study is to assess the effect of evolocumab on coronary plaque morphology using intravascular imaging and gene expression analysis of peripheral blood mononuclear cells (PBMC) in patients with stable CAD on maximally tolerated statin therapy. The study combines multi-modality intravascular imaging approaches and transcriptomic based machine learning algorithms to uncover molecular mechanisms responsible for the beneficial changes in atherosclerotic lesions of patients treated with evolocumab. The primary end-points are the changes from baseline to follow-up in (1) the minimal fibrous cap thickness (FCT) assessed by optical coherence tomography (OCT) and (2) maxLCBI4mm assessed by near-infrared spectroscopy ...

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    2. Plaque Erosion Prospective Study ii

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Plaque Erosion Prospective Study ii

      Plaque erosion is associated with myocardial infarction (MI) in about 30% of cases and may require a different management approach to plaque rupture. The investigators hypothesise that plaque erosion leads to higher levels of apoptotic circulating endothelial cells (CECs) compared to plaque rupture. Aims: To compare associations between plaque erosion and plaque rupture with numbers and types of apoptotic CECs in patients with non-ST elevation MI (NSTEMI) and stable coronary artery disease controls (CAD). Additional aims are to explore signals of cellular stress (mitochondrial dsDNA), sub-populations of activated neutrophils, circulating endothelial progenitor cells and erosion-specific plasma biomarkers. Methods: Prospective observational ...

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    3. Influence of Calcium Pattern on Plaque Modification Achieved With Intracoronary Lithotripsy

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Influence of Calcium Pattern on Plaque Modification Achieved With Intracoronary Lithotripsy

      Calcified coronary artery disease is a frequently encountered problem that can lead to poorer outcomes for patients undergoing PCI. Recently, intravascular lithotripsy has become available for the treatment of callcified coronary artery disease. The effect of intravascular lithotripsy on varying calcium patterns has not been adequately explored. This is an investigator initiated, open label, non-blinded, observational study involving a number of centers in Spain examining the effect of intravasuclar lithotripsy in varying calcium patterns. 100 patients wll be enrolled. Optical coherence tomography will be used to assess the effect of intravascular lithotripsy on varying calcium patterns (concentric, eccentric and nodular).

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    6. Deep Learning on 3D Cellular-resolution Tomogram

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Deep Learning on 3D Cellular-resolution Tomogram

      Skin biopsy is the main method to diagnose skin tumors, skin inflammation, and pigmented diseases. However, biopsy is an invasive method that can cause wounds and scars. Optical coherent tomography (OCT) technology is a fast, non-invasive, non-radioactive, and label-free imaging method. This technology generates real-time images of living tissue by detecting the variations in the refractive indexes of various components in soft tissues. Recently, there is a breakthrough progress that the newly designed ultrahigh resolution OCT can provide in vivo cellular resolution similar to histopathological sections in the high magnification. In our previous clinical trial "Early feasibility study: application of ...

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      Mentions: National Taiwan University Sheng-Lung Huang

    7. The Use of a OCT Probe in Assessment of Endoscopic and Surgical Resection Specimen of Gastrointestinal Tract

      Explore Home - ClinicalTrials.gov Gastroenterology , Clinical Trials
      The Use of a OCT Probe in Assessment of Endoscopic and Surgical Resection Specimen of Gastrointestinal Tract

      This is a pilot study aiming to investigate the ability of a novel Optical Coherence Tomography (OCT) probe in assessing the different layers of the gastrointestinal tract and the depth of invasion of early neoplasia, utilising surgically and endoscopically resected specimens Endoscopic treatment of early neoplasia in the gastrointestinal tract has been established as the standard therapy in the past decade. Various endoscopic resection techniques have been developed, such as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), to ensure complete removal of such lesions and avoid recurrence. Successful endoscopic resection of early gastrointestinal (GI) neoplasia relies on accurate ...

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      Mentions: The Chinese University of Hong Kong University of Hong Kong

    8. Drug-coated Balloon Versus Drug-eluting Stent for de Novo Lesions in Large Coronary Arteries Guided by Optical Coherence Tomography

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Drug-coated Balloon Versus Drug-eluting Stent for de Novo Lesions in Large Coronary Arteries Guided by Optical Coherence Tomography

      OCT allows precise evaluation of intimal injury after lesion preparation and may improve the acute results and long-term outcomes after paclitaxel drug-coated balloon angioplasty. This prospective multicenter randomized controlled study aims to evaluate the long-term efficacy and safety of paclitaxel coated balloon in the treatment of native large coronary arteries by OCT guided is not inferior to drug-eluting stent.

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    11. Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting

      EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE (prosthetic replacement of the ocular surface ecosystem) devices could be replaced and/or strengthened with a more rapid, automated fitting sequence. This could considerably reduce the time needed per visit, the number of visits, and the number of devices needed to be manufactured to reach the endpoint. Additionally, the scanning technology may afford the opportunity to successfully fit some pathology that were previously treatment failures. The automated technology may as ...

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    12. "Predicting Glaucoma Progression With Optical Coherence Tomography Structural and Angiographic Parameters".

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      "Predicting Glaucoma Progression With Optical Coherence Tomography Structural and Angiographic Parameters".

      Subjects will go a comprehensive ophthalmologic examination including review of medical history, best-corrected visual acuity (BCVA), slit-lamp biomicroscopy, intraocular pressure (IOP) measurement, gonioscopy, dilated fundoscopic examination, stereoscopic optic disc photography, and automated perimetry using Swedish Interactive Threshold Algorithm (SITA Standard 24-2). Only subjects with open angles on gonioscopy were included. One eye of each subject will be scanned by a high-speed 1050-nm-wavelength swept-source OCT instrument. OCT is providing measurements of the RNFL thickness, ONH, as well as the inner macula for the assessment of glaucoma progression. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm will be used to compute 3-dimensional optic disc ...

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    13. Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography

      Cachectic patients and controls undergoing a comprehensive ophthalmologic examination. The imaging of all subjects is undertaken using a commercial OCTA device with a scan rate of 70,000 A-scans/s, scan beam wavelength of 840 ± 10 nm and bandwidth of 45 nm. All measurements are performed between 10:00 and 12:00 on the same day. The OCTA images are independently graded and assessed by two retinal specialists. The software automatically segmented these full-thickness retinal scans into the superficial and deep inner retinal vascular plexuses, outer retina, and choriocapillaris (CC). The vascular density in the superficial and deep retinal vascular ...

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      Mentions: Optovue Topcon Medical Systems Haag-Streit

    14. Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA

      Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination are included. The Optical Coherence Tomography Angiography (OCTA) software automatically segments these full-thickness retinal scans into the superficial and deep inner retinal vascular plexuses, outer retina, and choriocapillaris (CC). The vascular density in the superficial and deep retinal vascular zones is calculated automatically by the software, and the foveal avascular zone (FAZ) and foveal density (FD) are also automatically determined. Choroidal thickness is calculated manually by two retinal specialists, and the average value was used.

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    15. AS OCT Evaluation for Perforated Punctual Plugs

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      AS OCT Evaluation for Perforated Punctual Plugs

      Prospective non randomized case series study included 50 eyes. The study is conducted on patients attending to the oculoplastic unit of ophthalmology department of Minia university hospital. Informed consents were obtained from the participants in this study. The study was adherent to the tenets of declaration of Heleniski. Anterior segment optical coherence tomography (AS-OCT) was performed for the included patients after perforated plug implantation (during the first operative weak)

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    16. Bimodal and Coaxial High Resolution Ophthalmic Imaging

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Bimodal and Coaxial High Resolution Ophthalmic Imaging

      The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging. However, optical aberrations of the ocular media limit the resolution that can be achieved by current techniques. The use of an adaptive optics system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many retinal microstructures: photoreceptors, vessels, bundles of nerve fibers. Recently, the development of the coupling of the two main imaging techniques, the Adaptive Optics Ophthalmoscope with Optical Coherence Tomography , enables unparalleled three-dimensional in vivo cell-scale imaging, while remaining comfortable for ...

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    18. Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

      Explore Home - ClinicalTrials.gov Dermatology , Oncology , Clinical Trials
      Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

      The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT). Another key question is whether subclinical OCT detected skin damage correlates with acute and late clinical toxicity.

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    20. Photoaging Reversing After Picosecond Laser With DLA Assessed by Cellular Resolution OCT in Asian Patient With Melasma

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Photoaging Reversing After Picosecond Laser With DLA Assessed by Cellular Resolution OCT in Asian Patient With Melasma

      Background Melasma is a commonly acquired hypermelanosis that affects facial sun exposed areas, most commonly in Asians and other darker skin type females. Recent evidence has demonstrated melasma to be a photoaging disorder. The histological findings of melasma are similar to photoaging and include solar elastosis, increased mast cells and sebaceous glands, as well as increased vascularization. Pendulous active melanocytes with weakened basal membranes, and changes in nuclear morphology and chromatin texture of adjacent basal keratinocytes also seemed to be a characteristic feature of melasma.

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      Mentions: Apollo Medical Optics

    23. Digital Wavefront Sensing

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Digital Wavefront Sensing

      H-OCT will be tested in this study for its suitability for the qualitative investigation of aberrometry. We aim to achieve a digital equivalent for wavefront calculation of the widespread analog procedure commonly used with conventional wavefront-aberrometers. The results will be compared with those from a conventional analog wavefront calculation method. In the course of this pilot study, 20 eyes of phakic and 10 eyes of pseudophakic subjects with suspected higher order aberrations will be examined using H-OCT

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      Mentions: Medical University of Vienna
    1-24 of 500 1 2 3 4 ... 19 20 21 »
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