Clinical Trials -Optical Coherence Tomography News

Articles in category: Clinical Trials

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1. Early Effects of Intensive Lipid Lowering Treatment With Ezetimibe/ Simvastatin (Vytorin®) Assessed by Virtual Histology-Intravascular Ultrasound (VH-IVUS) and Optical Coherence Tomography (OCT) on Plaque Characteristics in Patients With Acute Coronary Sy
  
  Explore ClinicalTrials.gov May 15 2013 Cardiology , Clinical Trials
  
  Objective: To evaluate the early effects of intensive lipid lowering treatments with ezetimibe/simvastatin (Vytorin®) for each component of coronary plaques. Study Design Prospective, randomized, single-center study of each 80 subjects enrolled Subjects with acute coronary syndrome who meet all inclusion and exclusion criteria will be enrolled. Eligible subjects will be randomized 1:1 to A) Ezetimibe/Simvastatin (n=80) vs. B) Pravastatin (n=80), and each group of patients will be randomized further in a ratio of 1:1 to a) ZES (n=40) vs. b) EES (n=40), according to the type of stent used. All subjects will ...
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  Mentions: Yonsei University Myeong-Ki Hong
2. Serial EValuation of multiplE Coronary Artery Diseases by an Optical Coherence Tomography; Assessment of the Changes of de Novo Lesions and Comparisons of Neointimal Coverage Between Xience Prime® Versus Cypher SelectTM Stents; SEVEN-Xience Study
  
  Explore ClinicalTrials.gov May 9 2013 Cardiology , Clinical Trials
  
  This study is a prospective open-labeled, randomized study to compare the neointimal coverage at 3 months and 12 months and its serial changes between 3 months and 12 months according to the implanted DES and evaluate the serial changes in the proximal portions of 3 epicardial coronary artery and left main artery including the assessment of fibrous cap thickness and lipid pool for vulnerable plaques by OCT. In addition, the investigators will compare the changes such as plaques and neointimal coverage from serial OCT follow-up according to the different statin strategy.
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  Mentions: Yonsei University Myeong-Ki Hong
3. Endothelial Injury and Development of Coronary Intimal Thickening After Heart Transplantation
  
  Explore ClinicalTrials.gov May 2 2013 Cardiology , Clinical Trials
  
  Coronary allograft vasculopathy (CAV) is the leading cause of late graft failure and second leading cause of late mortality after heart transplantation. CAV has been associated with a variety of traditional risk factors for atherosclerosis; however, immune mediated injury from development of de-novo donor-specific antibodies after transplantation also likely plays an important role. Similar to the progression of traditional atherosclerosis, it is likely that endothelial dysfunction is the precursor to the development of intimal thickening and CAV. The investigators hypothesize that coronary allograft vasculopathy after heart transplantation as defined by progressive neointimal hyperplasia is preceded by endothelial dysfunction, which in ...
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  Mentions: University of Pittsburgh
4. Measurement of Total Retinal Blood Flow in Patients With Diabetes and Healthy Subjects
  
  Explore ClinicalTrials.gov Apr 26 2013 Ophthalmology , Clinical Trials , Doppler
  
  The prevalence of diabetes and diabetes-associated complications is still increasing. Several major long-term complications of diabetes such as cardiovascular disease, chronic renal failure, diabetic retinopathy and others relate to the damage of blood vessels. Given that the eye provides the unique possibility in the human body to directly visualize blood vessels, much interest has been directed towards studying the ocular circulation. Although data of large epidemiological studies indicate that changes in retinal vessel caliber reflect other diabetes related factors, such as fasting glucose levels, there is still conflicting evidence on blood flow alterations in patients with diabetes. This is also ...
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  Mentions: Medical University of Vienna
5. Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study
  
  Explore ClinicalTrials.gov Apr 26 2013 Ophthalmology , Clinical Trials
  
  The aim of the present study is to develop a protocol for optimal corneal 3-dimensional imaging based on measurements in healthy volunteers. For this purpose, a customized ultra-high resolution Spectral Domain OCT will be used. To validate whether the protocol can also be applied in patients with corneal pathologies, for whom it is intended to be used, measurements in these patients will be performed. We propose to obtain images from patients with keratoconus, since this is one of the most frequent causes for corneal transplantations in Europe and from patients with corneal neovascularization which is a major cause of vision ...
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  Mentions: Medical University of Vienna
6. Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging
  
  Explore ClinicalTrials.gov Apr 15 2013 Ophthalmology , Clinical Trials
  
  This is a clinical pilot study to assess the feasibility of using a swept-source optical coherence tomography (SSOCT) system to perform noninvasive imaging of the retinal vasculature in patients with existing microvascular disease.
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  Mentions: Duke University
7. Comparison of Ticagrelor Versus Clopidogrel on Residual Thrombus Burden During PCI: an OCT Study
  
  Explore ClinicalTrials.gov Apr 1 2013 Cardiology , Clinical Trials
  
  Subjects with acute coronary syndromes scheduled for cardiac catheterization will be enrolled in this study. Subjects that are to be treated clinically with coronary artery stenting will be randomized to receive a loading dose of clopidogrel versus ticagrelor after diagnostic angiography but prior to stenting. Optical coherence tomography (OCT) will be performed after stenting and the presence of blood clots inside the new stent will be measured and compared between the groups.
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Massachusetts General Hospital OCT Registry
8. FFR or OCT Guidance to RevasculariZe Intermediate Coronary Stenosis Using Angioplasty
  
  Explore ClinicalTrials.gov Mar 28 2013 Cardiology , Clinical Trials
  
  Whether to revascularize patients with angiographically-intermediate coronary lesions (AICL) is a major clinical issue. Intravascular techniques (assessing either the anatomy or the functional effect of coronary stenoses) are routinely used to better characterize coronary lesions. Among these, flow fractional reserve (FFR) provides validated functional insights while optical coherence tomography (OCT) provides high resolution anatomic imaging. Both techniques may be applied to guide decisions regarding the opportunity to revascularize patients with AICL and to optimize the result of percutaneous coronary intervention (PCI). We aim to compare the clinical and the economical impact of FFR versus OCT guidance in the percutaneous management ...
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9. Evaluate the Port-wine Stain Birthmark Treatment Before and After Pulsed Dye Laser Treatment
  
  Explore ClinicalTrials.gov Jan 22 2013 Dermatology , Clinical Trials
  
  Port-wine stain is a congenital, progressive vascular malformation of human skin involving post-capillary venules that occurs in an estimated 0.3% of children and can alter personality development and psychological in children.
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  Mentions: UC Irvine
10. Repeated Eye Injections of Aflibercept for Treatment of Wet Age Related Macular Degeneration
  
  Explore ClinicalTrials.gov Jan 17 2013 Ophthalmology , Clinical Trials
  
  To evaluate the visual outcome and number of injections required during an optical coherence tomography (OCT)-guided treat and extend regimen with intravitreal aflibercept for treatment of subfoveal neovascular age-related macular degeneration (NVAMD).
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11. The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques
  
  Explore ClinicalTrials.gov Jan 16 2013 Cardiology , Clinical Trials
  
  The Prediction of Extent and Risk Profile of Coronary Atherosclerosis (Examined by Intravascular Ultrasound, Virtual Histology and Optical Coherence Tomography) and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques.
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  Mentions: University of Iowa
12. OptiCal COherence ToMography ABoard InformiNg AtherEctomy
  
  Explore ClinicalTrials.gov Jan 14 2013 Cardiology , Clinical Trials
  
  This is a prospective, multi-center, non-randomized single arm feasibility trial of the Wolverine OCT guided atherectomy system.The trial will enroll up to 50 subjects diagnosed with peripheral vascular disease of the lower extremities.The primary disease must be located in reference vessel diameters ≥ 2.5 mm which is significant enough to cause moderate to severe symptoms and warrant vascular intervention.
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  Mentions: Avinger
13. Study the Signs of Ocular Degeneration in a Population Cohort (Dijon 3C Cohort)
  
  Explore ClinicalTrials.gov Jan 10 2013 Ophthalmology , Clinical Trials
  
  The aim of the study proposed in Dijon is above all to focus on the possible relationship between age-related ocular pathologies (AMD and glaucoma) and et les degenerative neurological and cardiac pathologies. The principal objective is to seek in subjects who have undergone cerebral MRI and echocardiography, associations between the thickness of postganglionic fibers measured by Optical Coherence Tomography at the 7th year (n=1500) and signs of cerebral impairment (psycho-cognitive tests, circulation time, MRI signs). This association will be studied after taking into account the principal environmental (particularly dietary) and genetic risk factors.
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14. Microvascular and Fibrosis Imaging Study
  
  Explore ClinicalTrials.gov Dec 26 2012 Dermatology , Clinical Trials
  
  In this study we will use Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), and Optical Coherence Tomography (OCT) to assess differences in microvascular function and density of oral mucosa and skin in subjects with 1) autoimmune diseases with cutaneous involvement: systemic sclerosis (SSc), morphea, dermatomyositis, cutaneous lupus and vasculitis, 2) sickle cell disease (SCD) and 3) chronic graft-versus-host disease (GVHD) compared to healthy subjects. We plan to compare the microvascular changes to overall treatment response in patients with scleroderma and chronic GVHD as assessments will be made before and after the patients start treatment ...
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  Mentions: Duke University
15. EGO-COMBO Angiographic Extension Study
  
  Explore ClinicalTrials.gov Dec 20 2012 Cardiology , Clinical Trials
  
  Evaluation of Endothelial ProGenitor Cell Capture Sirolimus-Eluting Stent by Optical Coherence Tomography: the COMBO Stent angiographic extension Study (EGO-COMBO angiographic extension Study)
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  Mentions: University of Hong Kong
16. St. Jude Medical Enrolls First Patient in ILUMIEN I Study to Develop Guidance for Stent Optimization
  
  Explore Optical Coherence Tomography News Dec 19 2012 Cardiology , Clinical Trials
  
  St. Jude Medical Press Release - St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the first patient enrollment in its ILUMIEN I clinical study. This observational study is designed to show the optimal way Optical Coherence Tomography (OCT), an intravascular imaging technology, combined with the St. Jude Medical PressureWire ™ Aeris , a wireless interventional tool that measures Fractional Flow Reserve (FFR), can guide stent implantation in patients with coronary artery disease. The study will observe and record how physicians treat patients while undergoing Percutaneous Coronary Intervention (PCI), and will also measure outcomes according to various procedural parameters ...
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  Mentions: David Holmes St. Jude Medical Frank J. Callaghan
17. A randomized multicenter comparison of hybrid sirolimus-eluting stents with bioresorbable polymer versus everolimus-eluting stents with durable polymer in total coronary occlusion: rationale and design of the Primary Stenting of Occluded Native Coronary A
  
  Explore Trials Dec 15 2012 Cardiology , Clinical Trials
  
  Background Percutaneous recanalization of total coronary occlusion (TCO) was historically hampered by high rates of restenosis and reocclusions. The PRISON II trial demonstrated a significant restenosis reduction in patients treated with sirolimus-eluting stents compared with bare metal stents for TCO. Similar reductions in restenosis were observed with the second-generation zotarolimus-eluting stent and everolimus-eluting stent. Despite favorable anti-restenotic efficacy, safety concerns evolved after identifying an increased rate of very late stent thrombosis (VLST) with drug-eluting stents (DES) for the treatment of TCO. Late malapposition caused by hypersensitivity reactions and chronic inflammation was suggested as a probable cause of these VLST. New ...
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  Mentions: Tom Adriaenssens
18. DETErmination of the Duration of the Dual Antiplatelet Therapy by the Degree of the Coverage of The Struts on Optical Coherence Tomography From the Randomized Comparison Between Everolimus-eluting Stents Versus Biolimus A9-eluting Stents; DETECT-OCT Trial
  
  Explore ClinicalTrials.gov Dec 14 2012 Cardiology , Clinical Trials
  
  The purpose of the study is 1> to compare neointimal stent coverage after OCT-guided vs. Angio-guided PCI, 2> to compare neointimal stent coverage at 3 months after EES (Xience Prime®) vs N-BES (Nobori®) implantation, and 3> to determine the duration of dual antiplatelet therapy by OCT measurement at 3 months.
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  Mentions: Yonsei University
19. Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
  
  Explore ClinicalTrials.gov Dec 7 2012 Ophthalmology , Clinical Trials
  
  Dry eye syndrome (DES) is a highly prevalent ocular condition with severe consequences for the patients reaching from ocular discomfort in its simplest form up to visual impairment and corneal ulceration in severe cases. Data from epidemiological studies indicate that DES is a common disease, especially in the elderly population, affecting up to 20% of adults aged 45 years or older. Topical lubricants are a mainstay of therapy, but data on its effect on tear film thickness and the corneal residence time are lacking. Recently, a new objective method for assessment of tear film thickness by optical coherence tomography has ...
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  Mentions: Medical University of Vienna
20. Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy
  
  Explore ClinicalTrials.gov Dec 7 2012 Ophthalmology , Clinical Trials
  
  Recently, a new and sophisticated method for assessment of retinal blood flow and retinal blood flow velocity profiles has become available. This technique is based on the combination of measurement of retinal vessel calibers with bidirectional Fourier domain optical coherence tomography (FDOCT). The valid measurement of retinal blood flow is of significant importance, because it is known that major ophthalmic diseases, such as hypertensive retinopathy, are associated with alterations in blood flow. Hypertensive retinopathy is the most common manifestation of arterial hypertension in the eye. Elevated systemic blood pressure leads to generalized arteriolar narrowing caused by vasospasms and increased vascular ...
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  Mentions: Medical University of Vienna
21. High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study
  
  Explore ClinicalTrials.gov Dec 7 2012 Ophthalmology , Clinical Trials
  
  Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions. The present study has the character of a pilot study and the results are intended to be used to develop a standardized protocol for imaging and analysis of these corneal lesions. Based on this protocol, further studies investigating the pathophysiology of corneal lesions or evaluating therapeutic success can be planned. 2
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  Mentions: Medical University of Vienna
22. Assessment of Retinal Vessel Diameters and Red Blood Velocities in Patients With BRVO and Healthy Subjects
  
  Explore ClinicalTrials.gov Dec 7 2012 Ophthalmology , Clinical Trials
  
  Assessment of retinal vessel calibers combined with bidirectional Fourier domain optical coherence tomography (FDOCT) for measurement of retinal blood velocities is a new and sophisticated method for assessing retinal blood flow in humans. The valid measurement of retinal blood flow is of significant importance, because it is known that major ophthalmic diseases are associated with alterations in blood flow. As such, retinal vascular occlusive diseases represent a major cause of visual impairment and blindness. The prevalence of the disease is between 0.7 and 1.6%. Compression of the retinal veins at arterio-venous (AV) crossings plays an important role in ...
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  Mentions: Medical University of Vienna
23. Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
  
  Explore ClinicalTrials.gov Dec 7 2012 Ophthalmology , Clinical Trials
  
  A prospective, observational, case series investigating the feasibility of utilizing OCT scans of the anterior chamber of eyes with uveitis.
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  Mentions: Cleveland Clinic
24. Advanced Glaucoma Progression Study (AGPS)
  
  Explore ClinicalTrials.gov Dec 3 2012 Ophthalmology , Clinical Trials
  
  Glaucoma is one of the leading causes of blindness in the world. The key to prevention of visual loss from glaucoma is early detection of the disease or its progression and timely treatment. The proposed study will investigate the role of various tests in improving detection of disease progression in advanced glaucoma. Evaluation of the peripheral field of vision (visual field examination) remains the current standard for detection of progression in glaucoma. However, there is a lot of variability or inconsistency in eyes with advanced glaucoma, which could make it difficult to detect worsening of glaucoma with visual fields. The ...
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  Mentions: National Eye Institute UCLA
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