Clinical Trials -Optical Coherence Tomography News

Articles in category: Clinical Trials

1-24 of 214 1 2 3 4 5 6 7 8 9 »
1. Single-centre, Registry Trial, the Patients Presented With Stable Coronary Artery Disease
  
  Explore ClinicalTrials.gov Feb 10 2015 Cardiology , Clinical Trials
  
  This is a prospective study to analyze the outcome of provisional main vessel stenting on side branch by utilizing Two-Dimensional (2D) and Three-Dimensional (3D) frequency domain optical coherence tomography (FD-OCT). To analyze the fate of side-branch after provisional main vessel stenting based on morphology defined prior to PCI by OCT. Offline analysis of side branch impingement of the ostium of SB leading to acute loss in SB diameter area, carina shift and plaque shift will be also be performed.
  Read Full Article
  
  Comment
  
  Mentions: Mount Sinai School of Medicine Boston Scientific
2. Automatic Early Melanoma Detection by Ultrahigh Resolution Three Dimensional Optical Coherence Tomography
  
  Explore ClinicalTrials.gov Jan 7 2015 Dermatology , Oncology , Clinical Trials
  
  We will use optical coherence tomography to detect the ex-vivo tissue image of surgical removed melanoma or other benign pigmented lesions of skin.
  Read Full Article
  
  Comment
  
  Mentions: National Taiwan University
3. 3D Single Cell Analysis Using Cell Morphology and Organelle Scattering Texture
  
  Explore ClinicalTrials.gov Jan 7 2015 Clinical Trials
  
  Achieved formalin-fixed paraffin embedded tissue specimens from colon cancers and/or other benign and pre-cancer colon lesions as well as melanoma and/or other benign pigmented skin lesions will be used. The achieved specimens were kept in Department of Pathology, National Taiwan University Hospital. Sections of achieved pathological specimens were put on glass slides and tissue image will be observed by 3D optical coherence tomography (OCT). The 3D optic tomography system utilize a Ce:YAG optical fiber as light source and also combined with confocal microscopy. Taken together, these features made the 3D optic tomography system have very high resolution ...
  Read Full Article
  
  Comment
  
  Mentions: National Taiwan University
4. Assessment of Coronary Plaque Composition Using Optical Coherence Tomography
  
  Explore Home - ClinicalTrials.gov Dec 19 2014 Cardiology , Clinical Trials
  
  The investigators hypothesis is that local activation of the endogenous Lp-PLA2 plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial dysfunction and to the structural and mechanical properties that characterize plaque vulnerability. Thus, the investigators study will characterize prospectively the correlation between the functional and structural vascular wall properties, and the activity of the Lp-PLA2 pathway.
  Read Full Article
  
  Comment
5. Computed Optical Margin Assessment for Breast Cancer Surgery, Phase I (Part B)
  
  Explore ClinicalTrials.gov Dec 5 2014 Oncology , Clinical Trials
  
  This intraoperative study is a prospective study analyzing specimens from fifty subjects. Patients scheduled to undergo breast- conserving surgery will be recruited in accordance with the inclusion and exclusion criteria. The study period per subject is the time it takes to assess the ex vivo breast tissue sample using the study device. Image review will be conducted during surgery and compared to the margin status findings in the post-operative pathology report.
  Read Full Article
  
  Comment
  
  Mentions: Johns Hopkins University Diagnostic Photonics
6. Vascular Healing After Deployment of Titanium-nitride-oxide-coated OPTIMAX™ Stent and PROMUS-ELEMENT™ Everolimus-Eluting Stent
  
  Explore ClinicalTrials.gov Oct 30 2014 Cardiology , Clinical Trials
  
  The purpose of this study is to compare vascular healing of the stented segment after deployment of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent stent and Promus-Element™ everolimus-eluting stent in patients with acute coronary syndromes requiring percutaneous coronary intervention. Comparison of OCT and CFR findings of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent and Promus-Element™ everolimus-eluting stent at two months after the index procedure. Comparison of intravascular coronary flow reserve measurement to non-invasive transthoracic echocardiography-derived coronary flow reserve measurement. Comparison of epicardial vasodilation to coronary microcirculatory vasodilation
  Read Full Article
  
  Comment
7. A Clinical and Imaging Study to Evaluate a Novel Dentifrice
  
  Explore ClinicalTrials.gov Oct 21 2014 Dentistry , Clinical Trials
  
  The purpose of this study is to evaluate the effects of toothpaste name Livionex by use imaging devices call Optical Coherence Tomography and Multiphoton Microscopy to measure the change in gum tissue.
  Read Full Article
  
  Comment
  
  Mentions: UC Irvine
8. Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Stent Implantation
  
  Explore ClinicalTrials.gov Oct 21 2014 Cardiology , Clinical Trials
  
  Coronary artery disease is one of the most prevalent diseases in the western countries. A waxy substance called plaque can build up inside the coronary arteries. Over time, plaque can harden or rupture, and cause narrowing (stenosis) of the arteries and reduce the flow of oxygen-rich blood to the heart. The standard treatment of symptomatic coronary stenosis is percutaneous coronary intervention (PCI) with balloon dilation followed by stent implantation. A stent is a small metallic grid that stabilizes the coronary vessel wall after the balloon dilation. Currently, drug-eluting stents (DES) are the most widely used stent types. DESs consist of ...
  Read Full Article
  
  Comment
9. OCT Angiography in Wet AMD
  
  Explore ClinicalTrials.gov Sep 25 2014 Ophthalmology , Clinical Trials
  
  The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) evaluate patients undergoing treatment for wet AMD determine if reduced flow to the choroid is a risk factor for developing wet AMD.
  Read Full Article
  
  Comment
  
  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
10. SDOCT-GMPE Software
  
  Explore ClinicalTrials.gov Sep 5 2014 Ophthalmology , Clinical Trials
  
  The investigators prospectively evaluate the new glaucoma premium edition (GMPE) software for spectral domain optical coherence tomography (SDOCT) and if this software is superior to the conventional one that is currently used for SDOCT.
  Read Full Article
  
  Comment
  
  Mentions: Duke University Sanjay G. Asrani
11. Preoperative Progression of Macular Holes
  
  Explore ClinicalTrials.gov Jul 28 2014 Ophthalmology , Clinical Trials
  
  Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre- optical coherence tomography era. By observing macular holes preoperatively we are able to determine the extent of the preoperative macular hole progression. At our institution macular holes are treated in an elective setting. The majority of macular holes undergo a 2-step sequence of phacoemulsification and intraocular lens implantation followed by vitrectomy. We wish to observe the effect of time and cataract surgery on the progression of macular holes prior to vitrectomy.
  Read Full Article
  
  Comment
12. Qvanteq Bioactive Coronary Stent System First in Man (FIM) Clinical Investigation
  
  Explore ClinicalTrials.gov Jun 25 2014 Cardiology , Clinical Trials
  
  Objective of this First in Man study is to assess feasibility and safety of Qvanteq's bioactive coronary stent for treatment of stable coronary artery disease patients with de novo coronary artery stenosis in native vessels. The proprietary surface of Qvanteq's bioactive coronary stent improves the in-growth behavior of the stent in the treated vessel. In-vivo animal studies revealed fast in-growth (similar to BMS), which however is not resulting in excessive tissue overgrowth as observed in BMS but rather has an efficacy profile similar to drug-eluting stent (DES), meaning suppression of tissue overgrowth. This should reduce the risk of ...
  Read Full Article
  
  Comment
  
  Mentions: Patrick W. Serruys Erasmus University
13. Does optical coherence tomography optimize results of stenting? Rationale and study design.
  
  Explore ScienceDirect May 26 2014 Cardiology , Clinical Trials
  
  Background To date, no randomized study has investigated the value of optical coherence tomography (OCT) in optimizing the results of coronary angioplasty for non-ST elevation acute coronary syndromes (NSTE-ACS). Methods DOCTORS is a randomized, prospective, multicentre, open-label clinical trial to evaluate the utility of OCT to optimize results of angioplasty of a lesion responsible for NSTE-ACS. Patients (n = 250) will be randomized to undergo OCT-guided angioplasty (use of OCT to optimise procedural result, including change to strategy with the possibility of additional interventions); or angioplasty under fluoroscopy alone. The primary endpoint is the functional result of the angioplasty procedure as ...
  Read Full Article
  
  Comment
14. OCT in Rare Chorioretinal Diseases
  
  Explore Home - ClinicalTrials.gov May 20 2014 Ophthalmology , Clinical Trials
  
  This study will evaluate the total blood flow in the retina and choroid (structures in the back of the eye) by Doppler optical coherence tomography (OCT) and OCT angiography. Angiography is mapping of the blood vessels. The purpose of measuring blood flow in the retina and choroid is to 1.) determine if rare diseases in these structures causes a change in blood flow compared to healthy eyes and 2.) find out if areas of changed blood flow line up with areas of damage that appear on conventional testing.
  Read Full Article
  
  Comment
  
  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
15. Optical Coherence Tomography to Evaluate Ticagrelor and Clopidogrel
  
  Explore ClinicalTrials.gov May 14 2014 Cardiology , Clinical Trials
  
  A number of 352 patients scheduled for elective percutaneous coronary intervention (PCI) with a native coronary stenosis suitable for DES implantation and OCT imaging are openly randomized 1:1 to either BRILINTA™ (ticagrelor) or Plavix® (clopidogrel bisulfate).
  Read Full Article
  
  Comment
16. Optical Coherence Tomography (OCT) in Hypertension & Chronic Kidney Disease (CKD)
  
  Explore ClinicalTrials.gov Apr 29 2014 Urology , Clinical Trials
  
  Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes. Part of this risk is due to changes in the structure and function of the blood vessels throughout the body. It is thought that reducing high blood pressure and treating chronic kidney disease improves the structure and function of blood vessels but information on this is limited. Optical coherence tomography (OCT) is a method of looking at the blood vessels at the back of the eye. It is a simple, quick and non-invasive test that you may have previously ...
  Read Full Article
  
  Comment
17. Fractional flow reserve or optical coherence tomography guidance to revascularize intermediate coronary stenosis using angioplasty (FORZA) trial: study protocol for a randomized controlled trial
  
  Explore Trials Apr 25 2014 Cardiology , Clinical Trials
  
  Background The management of patients with angiographically intermediate coronary lesions is a major clinical issue. Fractional flow reserve provides validated functional insights while optical coherence tomography provides high resolution anatomic imaging. Both techniques may be applied to guide management in case of angiographically intermediate coronary lesions. Moreover, these techniques may be used to optimize the result of percutaneous coronary intervention. We aim to compare the clinical and economic impact of fractional flow reserve versus optical coherence tomography guidance in patients with angiographically intermediate coronary lesions. Methods Patients with at least one angiographically intermediate coronary lesion will be randomized (ratio 1 ...
  Read Full Article
  
  Comment
18. Optical Coherence Tomography to Investigate FFR-Guided DEB-only Elective Coronary Angioplasty (OCTOPUS-2)
  
  Explore ClinicalTrials.gov Apr 19 2014 Cardiology , Clinical Trials
  
  We aimed to evaluate feasibility and the 6-month angiographic and OCT results of FFR - guided use of paclitaxel-eluting balloons (Sequent Please™, B Braun) with provisional bare metal stenting for elective PCI of de novo coronary lesions.
  Read Full Article
  
  Comment
19. Optical Coherence Tomography in Staging Patients With Upper Tract Urothelial Cancer
  
  Explore ClinicalTrials.gov Apr 7 2014 Oncology , Urology , Clinical Trials
  
  This clinical trial studies how well optical coherence tomography works in staging patients with upper-tract urothelial carcinomas. Staging describes the severity of a person's cancer based on the size and/or extent (reach) of the original (primary) tumor and whether or not cancer has spread in the body. It also helps the doctor plan the appropriate treatment. Optical coherence tomography is a procedure that uses infrared light waves to give three-dimensional pictures of structures inside tissues and organs. The pictures are made by a computer linked to the light source. Optical coherence tomography may be effective in staging patients ...
  Read Full Article
  
  Comment
  
  Mentions: National Cancer Institute
20. Yonsei OCT (Optical Coherence Tomography) Registry for Evaluation of Efficacy and Safety of Coronary Stenting
  
  Explore ClinicalTrials.gov Mar 25 2014 Cardiology , Clinical Trials
  
  Optical coherence tomography (OCT) has been recently studied for evaluation of coronary stenting. Because of high resolutions, several reports have shown that OCT is appropriate for evaluating neointimal tissue after coronary stent implantation. Also, the strut coverage and the characterization of neointimal tissue can be accurately evaluated. Furthermore, OCT-defined coverage of a stent strut was proposed to be related with clinical safety in drug-eluting stents-treated patients. Therefore, we will evaluate the appropriateness of currently using coronary stents (e.g. Sirolimus eluting stent, Paclitaxel-eluting stent, Zotarolimus-eluting stent, Everolimus-eluting stent, Biolimus eluting stent, EPC(endothelial progenitor cell) Capture stent, etc) based on ...
  Read Full Article
  
  Comment
  
  Mentions: Yonsei University Myeong-Ki Hong
21. Comparison of Biodegradable Stents: Orsiro and BioMatrix
  
  Explore ClinicalTrials.gov Mar 9 2014 Cardiology , Clinical Trials
  
  The use of a biodegradable polymer has the potential to reduce the sustained inflammatory response of the arterial wall, facilitating re-endothelialization and minimizing the risk of thrombus formation and late restenosis. In the study, we are going to two biodegradable polymer stents, Orsiro and BioMatrix, especially regarding the stent strut coverage by optical coherence tomography at 3 months after stent implantation. The primary objective of this study is to test the hypothesis that Orsiro is non-inferior to Biomatrix in terms of stent strut coverage by optical coherence tomography at 3 months. The secondary endpoint is clinical outcomes up to 1 ...
  Read Full Article
  
  Comment
  
  Mentions: Yonsei University
22. Non-Invasive Evaluation of Transplant Kidney Using OCT
  
  Explore ClinicalTrials.gov Mar 6 2014 Urology , Clinical Trials
  
  Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can function as a type of "optical biopsy", providing non-invasive cross-sectional images of tissue architectural morphology in situ and in real-time. This proposal will demonstrate that OCT has the ability to provide novel and valuable histopathological information regarding donor kidneys that can be used to predict post-transplant renal function. These investigations will result in a major breakthrough in increasing the number of healthy kidneys available for transplantation by making the most efficient use of available donor kidneys, eliminating the possible use of bad donor kidneys, providing an accurate measure ...
  Read Full Article
  
  Comment
  
  Mentions: Georgetown University
23. Optical Coherence Tomography to Improve Clinical Outcomes During Coronary Angioplasty
  
  Explore ClinicalTrials.gov Feb 12 2014 Cardiology , Clinical Trials
  
  Coronary artery stenting has evolved as an effective treatment for angina and involves stretching up narrowings within the heart arteries using a balloon (coronary angioplasty) before implanting a small metal scaffold (stent) to splint the artery open. It is imperative that stents are fully expanded when they are deployed. If not, then patients are exposed to the serious risk of a blood clot forming in the stent (stent thrombosis), or the stent renarrowing (restenosis). One fifth of patients experiencing stent thrombosis will die and 70% will suffer a heart attack. Restenosis is associated with recurrent angina and heart attacks. Arguably ...
  Read Full Article
  
  Comment
24. Comparison of the 3-month Strut Coverage After Coronary Stenting by Optical Coherence Tomography; Cilotax and DESyne
  
  Explore ClinicalTrials.gov Feb 7 2014 Cardiology , Clinical Trials
  
  We will compare the stent coverage at 3 months by optical coherence tomography (OCT) between the Cilotax and DESyne drug-eluting stents (DES). The extent of the strut uncoverage has not been evaluated yet for both the Cilotax and DESyne and we first sought to decide the reference intervals using 40 samples (total 44 patients for each group considering 10% drop-out rate) as the pilot study.
  Read Full Article
  
  Comment
  
  Mentions: Yonsei University
1-24 of 214 1 2 3 4 5 6 7 8 9 »