Category: Clinical Trials

1. OCT Companies in the News

   (10 articles) Carl Zeiss Meditec

   (5 articles) LightLab Imaging

   (4 articles) Boston Scientific

   (2 articles) Topcon Medical Systems

   (2 articles) Heidelberg Engineering

   (2 articles) Optovue

   (1 articles) Biosensors International

   (1 articles) Nidek

   (1 articles) Imalux

2. OCT Products in the News

   (6 articles) Zeiss Cirrus HD-OCT

   (4 articles) Zeiss Stratus OCT

   (2 articles) Heidelberg Spectralis

   (2 articles) Topcon 3D OCT-1000

   (2 articles) Optovue RTVue-100

   (1 articles) Lightlab M3 Imaging Console

   (1 articles) Imalux Niris

   (1 articles) Lightlab ImageWire

3. Organizations in the News

   (5 articles) Case Western Reserve University

   (4 articles) Yonsei University

   (4 articles) UC Irvine

   (3 articles) Catholic University of Leuven

   (3 articles) Ludwig Boltzmann Institute

   (1 articles) Prince of Songkla University

   (1 articles) San Raffaele Scientfic Institute

   (1 articles) Center for Ophthalmic Optics and Lasers

   (1 articles) European Society of Cardiology

   (1 articles) University of Zurich

4. People in the News

   (4 articles) Giulio Guagliumi

   (3 articles) Tom Adriaenssens

   (3 articles) Walter Desmet

   (2 articles) Gong Je Seong

   (2 articles) Matthew Brenner

   (1 articles) Kenichi Fujii

   (1 articles) Robert N. Weinreb

   (1 articles) Robert J. Noecker

   (1 articles) Mette Mogensen

   (1 articles) Hiroshi Ishikawa

1. Retinal Nerve Fiber Layer Thickness Measurements Using Optical Coherence Tomography in Patients With Sleep Apnea Syndrome

   Explore Article ClinicalTrials.gov (Aug 17 2010) Ophthalmology , Clinical Trials

   The purpose of this study was to measure the retinal nerve fiber layer (RNFL) thickness in eyes of Obstructive Sleep Apnea/hypopnea syndrome (OSAHS) using optical coherence tomography (OCT), and assess whether it is decreased. The investigators then compared the results with healthy subjects database of RNFL thickness from another retrospective study.
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

2. Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema

   Explore Article ClinicalTrials.gov (Jul 21 2010) Ophthalmology , Clinical Trials

   Assessment of optic disc morphology can be difficult in patients with uveitis and papilloedema. Therefore different optical coherence tomography (OCT) and laser scanning techniques may help to detect damage to the retinal nerve fibre layer
   

   Comment on Article

3. Optical Coherence Tomography for EVERolimus Eluting STent

   Explore Article ClinicalTrials.gov (Jun 16 2010) Cardiology , Clinical Trials

   Compared with bare metal stents (BMS), both paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) significantly reduce angiographic restenosis and the need for repeat revascularization in coronary arteries across a broad range of patient and lesion types. However the increased risk of very late stent thrombosis represents a major concern for patients treated with both PES and SES. Optical coherence tomography (OCT), a new imaging technique based on the back reflection of near infrared light, enables real-time, full tomographic, in-vivo visualization of coronary vessel microstructure. Struts coverage and vessel response of drug eluting stent (DES) compared to BMS are the most ...
   

   Comment on Article Mentions:   Case Western Reserve University   Boston Scientific   Giulio Guagliumi

4. Optical Coherence Tomography Assessment of Intimal Tissue and Malapposition

   Explore Article ClinicalTrials.gov (Jun 2 2010) Cardiology , Clinical Trials

   The purpose of this study is to use a high-resolution intracoronary imaging modality, called optical coherence tomography (OCT) to examine two different types of coronary artery stents used to treat patients with coronary artery disease. The development of coronary stents has significantly improved the safety and efficacy of percutaneous coronary intervention (PCI) compared to balloon angioplasty alone. Nevertheless, restenosis is still encountered in 20 to 40% of coronary lesions after implantation of bare metal stents, inferring frequent repeat revascularization procedures with a negative impact on quality of life and health care expenditures. Drug-eluting stents (DES), with their controlled release of ...
   

   Comment on Article Mentions:   Biosensors International   Peter Barlis

5. Optical Coherence Tomography in Long Lesions

   Explore Article ClinicalTrials.gov (May 28 2010) Cardiology , Clinical Trials

   Increasing lesion complexity in percutaneous coronary interventions (PCI) has warranted the use of overlapping drug-eluting stents. Whether the substantial impairment of arterial healing observed at sites of overlap in preclinical pathologic studies persists in patients undergoing PCI is unknown. Consecutive patients with long lesions in native coronary vessels requiring stents in overlap are prospectively assigned to receive multiple zotarolimus eluting stents (Resolute Sprint). The completeness of stent struts coverage and/or late malapposition are evaluated by Optical Coherence Tomography at 6 months follow-up.Data will be compared to the historical arm of ODESSA trial (patients treated with multiple sirolimus-,paclitaxel polymer-or zotarolimus eluting ...
   

   Comment on Article Mentions:   Case Western Reserve University

6. Relationship Between Macular Thickness Measurement and Signal Strength in Optical Coherence Tomography

   Explore Article ClinicalTrials.gov (May 2 2010) Ophthalmology , Clinical Trials

   ignal strength is a parameter introduced in analysis software version 4.0.1, of the OCT stratus, that combines SNR and uniformity of the signal within a scan The scale of signal strength ranges from 1 to 10, with 1 representing poor image quality and 10 representing excellent image quality It has been showed that signal strength has a better image quality discriminating ability than SNR The operation manual recommends a minimum signal strength of 5 for macular thickness measurement There is no consensus on the level of signal strength above which should be considered to be good quality The inclusion Criteria ...
   

   Comment on Article

7. The Massachusetts General Hospital Optical Coherence Tomography Registry

   Explore Article ClinicalTrials.gov (Apr 22 2010) Cardiology , Clinical Trials

   Information will be collected prospectively in about 3,000 patients having Optical Coherence Tomography during cardiac catheterization. Subjects will be initially enrolled at sites outside of the United States, where Optical Coherence Tomography is approved by regulatory agencies. Subjects will be followed for up to 5 years.
   

   Comment on Article Mentions:   Ik-Kyung Jang   Massachusetts General Hospital   LightLab Imaging

8. Test Safety of Biodegradable and Permanent Limus-Eluting Stents Assessed by Optical Coherence Tomography

   Explore Article ClinicalTrials.gov (Mar 31 2010) Cardiology , Clinical Trials

   The objective of the study is to assess the superiority of the biodegradable polymer based limus-eluting stents (ISAR G2, Nobori®) compared with the permanent polymer based everolimus-eluting stent (XIENCE V®) regarding absolute percentage of uncovered stent strut segments.
   

   Comment on Article

9. ComparisiOn of Neointimal coVerage betwEen ZES and EES Using OCT at 3 Months

   Explore Article ClinicalTrials.gov (Mar 22 2010) Cardiology , Clinical Trials

   This study try to 1) evaluate the neointimal coverage and malapposition at 3 month after new zotarolimus eluting stent (Endeavor resolute) and everolimus eluting stent (Xience) implantation and 2) compare them between ZES resolute and EES at 3 months (early period) after stent implantation.
   

   Comment on Article Mentions:   Yonsei University

10. Vessel Wall Response of the Bio-Active-stent and Everolimus-Eluting Stent Assessed By Optical Coherence Tomography (BASE-OCT)

    Explore Article ClinicalTrials.gov (Mar 3 2010) Cardiology , Clinical Trials

    e purpose of the trial is to evaluate the completeness of struts coverage and vessel wall response (strut malapposition, neoin-timal formation) to the bio-active-stent (BAS) versus ever-olimus-eluting stent (EES) implanted for the treatment of the culprit lesion in acute coronary syndrome.
    

    Comment on Article

11. Endothelial Function After Drug-Eluting Stent (DES)

    Explore Article ClinicalTrials.gov (Feb 22 2010) Cardiology , Clinical Trials

    The purpose of this study is to compare coronary endothelium function in patients with a zotarolimus-eluting versus a sirolimus-eluting or a everolimus-eluting stents with optical coherence tomography, vasoconstriction in response to acetylcholine, and coronary biomarker level.
    

    Comment on Article Mentions:   Kenichi Fujii

12. Comparison Between Foresee Home and Optical Coherence Tomography (OCT) Visual Field Defects in Patients With Choroidal Neovascularization (CNV)

    Explore Article ClinicalTrials.gov (Feb 22 2010) Ophthalmology , Clinical Trials

    The Foresee Home is used in the recent years to detect age-related macular degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal neovascularization (CNV). The Foresee Home demonstrates a high level of sensitivity and specificity as to the different stages of AMD including newly diagnosed or early detection of CNV. The OCT may be use as well to identify choroidal neovascularization (CNV). Comparison between the two methods will allow better understanding of both devices. The Foresee Home can use as an assessment tool for the progression and success ...
    

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13. The Performances of Spectral Domain Optical Coherence Tomography (OCT) for Distinguishing Glaucomatous Eyes

    Explore Article ClinicalTrials.gov (Feb 10 2010) Ophthalmology , Clinical Trials

    The purpose of this study is to evaluate performances of each parameters of spectral domain (Cirrus) optical coherence tomography for distinguishing between normal eyes, glaucoma suspect and glaucomatous eyes
    

    Comment on Article Mentions:   Prince of Songkla University   Carl Zeiss Meditec   Zeiss Cirrus HD-OCT

14. STACCATO: Stent sTrut Apposition and Coverage in Coronary ArTeries: an Optical Coherence Tomography (OCT) Study

    Explore Article ClinicalTrials.gov (Feb 8 2010) Cardiology , Clinical Trials

    Assessment of vessel healing after DES implantation in STEMI, NSTEMI and stable/unstable angina patients: a randomized comparison between everolimus and biolimus A9-eluting stents: an optical coherence tomography (OCT) and intravascular ultrasound-tissue characterisation (IVUS-TC) study. Plaque characterisation substudy: Assessment of culprit lesions in different subsets of patients (STEMI, NSTEMI and stable/unstable angina) by use of optical coherence tomography (OCT) and intravascular ultrasound tissue characterisation (IVUS-TC).
    

    Comment on Article Mentions:   Catholic University of Leuven   Tom Adriaenssens   Walter Desmet

15. SEDUCE: Safety and Efficacy of a Drug elUting Balloon in Coronary Artery rEstenosis:an Optical Coherence Tomography (OCT) Study

    Explore Article ClinicalTrials.gov (Feb 8 2010) Cardiology , Clinical Trials

    Different healing responses after treatment of bare metal stent restenosis with implantation of an everolimus-eluting Xience V stent (Abbott Vascular) versus use of a paclitaxel-eluting SeQuent Please balloon (BBraun): an optical coherence tomography study. A prospective, single-centre, randomized clinical trial with clinical, angiographic and OCT follow-up at 9 months.
    

    Comment on Article Mentions:   Catholic University of Leuven   Tom Adriaenssens   Walter Desmet

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