1. Articles in category: Clinical Trials

    1-24 of 402 1 2 3 4 ... 15 16 17 »

    1. Outcomes Based on the Pre-operative Integrity of IS/OS Junction in Idiopathic Epimacular Membrane Surgery

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Outcomes Based on the Pre-operative Integrity of IS/OS Junction in Idiopathic Epimacular Membrane Surgery

      The aim of this study is to evaluate whether the pre-operative integrity or not of the inner segment (IS) and outer segment (OS) photoreceptoral junction may influence the post-operative visual acuity, the macular morphology (assessed by Spectral Domain- Optical Coherence Tomography (SD-OCT)) and function (evaluated by Multifocal Electroretinogram -mfERG) in patients with idiopathic epimacular membrane (EMM) followed-up for 6-month. In this observational prospective study, EMM patients are enrolled. They are divided into 2 groups in relationship to the pre-operative integrity of the SD-OCT IS/OS junction: the group with an intact IS/OS junction (EMM-I Group) and the group with ...

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    3. Diagnostic Efficacy of FFOCT Imaging for Tissue Sample Obtained by EUSFNB

      Explore Home - ClinicalTrials.gov Clinical Trials
      Diagnostic Efficacy of FFOCT Imaging for Tissue Sample Obtained by EUSFNB

      In most Asian medical centers, rapid on-site cytology evaluation is not available, the number of needle passes of EUS-FNA is decided by endoscopists. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability information of cells/tissue, which could be more important in sample rapid evaluation.

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      Mentions: LLTech

    6. In-stent Repair and Vessel Reaction of STEMI Patients With OCT

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      In-stent Repair and Vessel Reaction of STEMI Patients With OCT

      This study is a prospective, multi-center, non-inferior, randomized controlled clinical trial, aims to use optical Coherence tomography to observe the the early- and mid-stage vessel repair and neointimal proliferation. And to assess the safety and effectiveness of the Firehawk™ sirolimus target-eluting coronary stent system with abluminal grooves containing a biodegradable polymer (Firehawk™) comparing the XIENCE everolimus-eluting coronary stent system in the treatment of subjects with ST-elevation myocardial infarction (STEMI).

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    8. Multimodal Ophthalmic Imaging

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Multimodal Ophthalmic Imaging

      Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye. The use of a high-resolution imaging system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many microstructures of the eye: photoreceptors, vessels, nerve bundles in the retina, cells and nerves in the cornea. The use of a high-speed acquisition imaging system makes it possible to detect functional measurements such as the speed of blood flow ...

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      Mentions: Michel Pâques

    9. Optical Coherence Tomography Guided Antithrombotic Treatment After Endovascular Thrombectomy of the Posterior Circulation

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Optical Coherence Tomography Guided Antithrombotic Treatment After Endovascular Thrombectomy of the Posterior Circulation

      Evidence regarding the role of early (<24 hours) antithrombotics post-revascularization with either intravenous thrombolysis (IVT), endovascular thrombectomy (EVT), or a combination of both remains scarce. In 2018 the American Heart Association/American Stroke Association changed their recommendation, stating that the risk of antithrombotic therapy within the first 24 hours after treatment with IVT (with or without EVT) is uncertain. This was changed after data emerged that early antithrombotics may be safe and may improve outcomes in select patients undergoing EVT. Recently our group showed for the first time that significant residual basilar thrombus can exist after EVT despite complete angiographic ...

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      Mentions: Sunnybrook Health Sciences Centre Victor X. D. Yang

    10. Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      Explore Home - ClinicalTrials.gov Oncology , Clinical Trials
      Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)

      The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques. The IHU-SPECTRA research unit, entirely dedicated to the development of fluorescence-guided surgery, was set up to test several innovations as part of a large-scale project (ELIOS: Endoscopic Luminescent Imaging for Precision Oncology Surgery), funded by the ARC Foundation for Cancer Research. The proposed research protocol is part of the ELIOS project and targets in particular colon tumours. The Holy Grail in oncology surgery is the radical removal of cancer cells in order to reduce the rate of tumour recurrences and increase ...

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      Mentions: LLTech

    11. Changes in Amblyopia Using Optical Coherence Tomography

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Changes in Amblyopia Using Optical Coherence Tomography

      There have been multiple trials to investigate the morphological changes in the macula and retinal nerve fiber layer of amblyopic eyes, due to the different published results and the lack of evident association between these changes and the patients' parameters. So, we perform this study to compare the variations in macular parameters (central thickness, average thickness, macular volume) and peripapillary thickness in different cases of amblyopic eyes versus the normal fellow eyes using spectral-domain optical coherence tomography . In addition, to estimate the relationship of optical coherence tomography variations with different defined patients' parameters (age, sex, best corrected visual acuity, spherical ...

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    14. Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy

      This study is a 48 week, single center, randomized controlled clinical trial. Approximately 150 subjects will be randomized into three separate arms. This study compares the efficacy of standard of care Lucentis (ranibizumab) monotherapy versus OCTA-Directed PDT Triple Therapy with Lucentis (ranibizumab), PDT with Visudyne (verteporfin), and Triescence (triamcinolone acetonide) in treatment-naïve patients with Exudative Age-Related Macular Degeneration. OCTA-Directed PDT Double Therapy with Lucentis (ranibizumab) and PDT with Visudyne (verteporfin) will also be tested to confirm the hypothesis that steroids are necessary.

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    15. Application of High Resolution Optical Coherence Tomography in Skin Disease: Amyloidosis and Differential Diagnosis

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Application of High Resolution Optical Coherence Tomography in Skin Disease: Amyloidosis and Differential Diagnosis

      Amyloidosis is caused by the misfolding protein accumulated in tissue, which affects the function of the organs. In addition to the primary cutaneous amyloidosis, a skin lesion may also appear in another classification - systemic amyloidosis. Physicians can confirm diagnosis of the above classification by skin biopsy. Primary cutaneous amyloidosis is common in Asia and South America. In Taiwan, 80 people are diagnosed with primary cutaneous amyloidosis in every 100,000 people. Among the disease, macular amyloidosis and lichen amyloidosis are the most common subtypes. Primary cutaneous amyloidosis can cause severe itching, pigmentation, and skin keratosis, and further affect the social ...

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      Mentions: Apollo Medical Optics

    16. Multicentre Registry of CCTA, IVUS and OCT

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Multicentre Registry of CCTA, IVUS and OCT

      The Invictus Registry will compare the diagnostic performance of coronary computed tomography angiography (CCTA) versus intravascular imaging by intravenous ultrasound (IVUS) or optical coherence tomography (OCT) for the measurement of minimum lumen area, the identification of stenosis severity, burden, morphology and vulnerability of coronary atherosclerosis.

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    17. Early Feasibility Study: Application of OCT Imaging in Dermatology

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Early Feasibility Study: Application of OCT Imaging in Dermatology

      Optical coherence tomography (OCT) is an established medical imaging technique that uses light to capture biological images from within optical scattering media (e.g., biological tissue). A high-resolution OCT has the characteristics of non-invasive, label-free, real-time, cellular resolution with high tissue penetration depth that are highly valuable for clinical use. Apollo Medical Optics, Ltd. (AMO)'s product originated at National Taiwan University (NTU), when AMO's researchers first began investigating medical optics. Apollo Medical Optics has developed a platform-based OCT tissue scanning system (B100) and have been conducting studies at the Mackay Memorial Hospital, Taipei as well as the Memorial ...

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      Mentions: Apollo Medical Optics

    18. Choroidal Thickness in Beta-thalassemia Patients

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Choroidal Thickness in Beta-thalassemia Patients

      The purpose of this study is to examine choroidal thickness in beta-thalassemia patients and compare it to the one of healthy controls. An equal number of transfusion dependent beta-thalassemic patients and age and sex matched healthy volunteers will undergo spectral-domain optical coherence tomography utilizing the enhanced depth imaging application to visualize and measure the choroid.

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      Mentions: Patras University

    20. Comparison of Coronary Lithoplasty and Rotablation

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Comparison of Coronary Lithoplasty and Rotablation

      Severe coronary calcification is still a challenge for percutaneous coronary intervention (PCI). Reduction of the calcified plaque mass is necessary to achieve adequate stent expansion during further course. Rotablation has been the only reliable option to treat extremely calcified coronary lesions for a long time. Coronary lithoplasty has been recently introduced as a new promising treatment option in this special subset. It provides the unique opportunity to break severely calcified plaque structures even inside deeper layers of the vessel wall. Aim of this study is to compare rotablation and coronary lithotripsy for treatment of severely calcified coronary lesions. Plaque structure ...

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    21. Treatment of Periodontal Disease in Systemic Lupus Erythematosus

      Explore Home - ClinicalTrials.gov Dentistry , Clinical Trials
      Treatment of Periodontal Disease in Systemic Lupus Erythematosus

      Many studies have conducted to evaluate the relationship of systemic inflammatory diseases with periodontal disease. Previous evaluations suggest that there is no significant association between patients with Systemic lupus erythematosus (SLE) and Periodontitis (PD). However, some of the studies have shown relevancy between these two inflammatory diseases and have suggested to explore more for further knowledge. The aim of the study is to establish and investigate a relationship between SLE and PD. The study which will take place in two centers and will recruit 30 patients which will enter a pilot randomized controlled trial. Individuals enrolled into the study will ...

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    22. OCT Feasibility Older Hip Fracture

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      OCT Feasibility Older Hip Fracture

      Optical coherent tomography (OCT) is a device used to achieve cross-sectional imaging of tissues. It is often used in ophthalmology and also has application in dermatology, cardiology and other specialities. Usually, in adults, a table-top device is used necessitating the transfer of patients to the location of the device. In children a hand held device is used meaning the device can be taken to the patients' location. To facilitate/ help design a future study, this study's aim is to assess the feasibility of achieving retinal imaging in older people who are recovering from hip fracture surgery using a hand ...

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    23. Vascular Responses After Percutaneous Coronary Intervention With Stenting In Patients With Obstructive Sleep Apnea

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Vascular Responses After Percutaneous Coronary Intervention With Stenting In Patients With Obstructive Sleep Apnea

      Obstructive sleep apnea (OSA) is an increasingly common chronic disorder in adults. Compared to the general population, OSA occurs more often in patients with coronary artery disease (CAD), with a reported prevalence of 38% to 65%. Emerging evidence indicates OSA initiates and exacerbates coronary atherosclerosis. Moreover, several observational studies indicate the presence of OSA was associated with higher rate of restenosis and repeat revascularization (mainly attributed non-culprit lesion revascularization) after percutaneous coronary intervention (PCI). OSA might initiate endothelial injury by repetitive bursts of sympathetic activity that occur with apneas and hypopneas. Moreover, untreated OSA reduces endothelial repair capacity. Whether OSA ...

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    24. Avinger Enrolls First 50 Patients in INSIGHT Clinical Trial

      Explore Optical Coherence Tomography News Cardiology , Clinical Trials , Other Business News
      Avinger Enrolls First 50 Patients in INSIGHT Clinical Trial

      Avinger, Inc. (NASDAQ: AVGR), a commercial-stage medical device company marketing the first-ever image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the 50 th patient enrolled in its INSIGHT clinical trial. The INSIGHT trial is a prospective, global, single arm, multi-center study to evaluate the safety and effectiveness of the Pantheris ® Lumivascular atherectomy system for treating in-stent restenosis (ISR) in lower extremity arteries. Dr. Jaafer Golzar, Avinger’s Chief Medical Officer and a highly experienced interventionalist, noted, “We are pleased to have the first 50 cases completed as part of our INSIGHT IDE study. Early ...

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      Mentions: Avinger
    1-24 of 402 1 2 3 4 ... 15 16 17 »
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