1. Articles in category: Clinical Trials

    1-24 of 617 1 2 3 4 ... 24 25 26 »

    1. Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression

      Data from human autopsy studies have showed that thrombosis of a ruptured plaque with a large necrotic core, inflammatory cells and a thin fibrous cap, the so-called thin cap fibroatheroma (TCFA), represents the main mechanism for acute coronary syndrome (ACS). Optical coherence tomography (OCT) is an imaging technique that provides high-resolution, cross-sectional images of tissue in situ. The resolution of OCT (10 um) is appropriate for measuring a cap thickness less than65 μm, and even the plaque macrophage density. 68Ga-DOTA-(Tyr3)-octreotate/NaI3-octreotide(68Ga-DOTA-TATE/NOC) Positron Emission Tomography (PET)/Computed Tomography coronary angiography (CTCA), targeting the somatostatin receptor subtype-2 selectively ...

      Read Full Article
      Mentions: University of Cambridge University of Bologna

    2. Comparing Conventional Grid Laser Photocoagulation and Subthreshold Micropulse Laser in Diabetic Macular Edema Using OCT Angiography

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Comparing Conventional Grid Laser Photocoagulation and Subthreshold Micropulse Laser in Diabetic Macular Edema Using OCT Angiography

      The prevalence of diabetes mellitus has increased significantly in Hong Kong for the past decade [1]. Diabetic macular edema is one of the most common causes of vision loss in patients suffering from diabetes mellitus [3]. Before the introduction of anti-vascular endothelial growth factor agents, laser photocoagulation has been the mainstay treatment for patients with diabetic macular edema. There are two types of laser treatment modalities, namely focal laser, which can be applied either in a grid pattern over a region of macular edema or to selected microaneurysms, and subthreshold micropulse laser. Only one meta-analysis published in 2016 [16] had ...

      Read Full Article
      Mentions: The Chinese University of Hong Kong

    3. Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy

      Explore Home - ClinicalTrials.gov Microscopy , Pulmonology , Clinical Trials
      Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy

      In this study, lymph node or lung nodule tissue will be collected by bronchoscopy as part of standard clinical care. The tissue is being collected to help make a diagnosis of a pulmonary condition. The same amount of tissue that is collected per standard of care for diagnosis will be collected during the study; no additional tissue is taken for this study. The biopsy sample will be analyzed by the Aquyre Biopsy Scanner which will provide images of unprocessed lung biopsy tissue taken during your procedure. A pathologist will also analyze the tissue sample in accordance with existing clinical guidelines ...

      Read Full Article
      Mentions: National Institutes of Health Boston University Aquyre Biosciences

    5. AI Quantitative Coronary Angiography Versus Optical Coherent Tomography Guidance for Coronary Stent Implantation

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      AI Quantitative Coronary Angiography Versus Optical Coherent Tomography Guidance for Coronary Stent Implantation

      This original clinical research project utilizes cutting-edge medical imaging technologies for diagnosis of pigmented skin tumours, combined for the first time in Denmark, with molecular RNA and lipid analysis of superficial tumours cells. The scanning technologies are reflectance confocal microscopy (RCM), which is a microscope applied directly to the skin surface, and photoacoustic imaging, also termed multispectral optoacoustic imaging (MSOT), which is an imaging technology actually listening to the skin for immediate bedside diagnosis of pigmented skin tumors. The hypothesis is that treatment guided by diagnostic bedside skin scanning, combined with tumour tape-stripping and RNA and lipid analysis can increase ...

      Read Full Article

    6. Adaptive Optics Imaging of Outer Retinal Diseases

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Adaptive Optics Imaging of Outer Retinal Diseases

      Objective: The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints. Study Population: Up to fifty (50) healthy volunteers without eye disease (Cohort 1) and up to fifty (50) affected participants with any type of outer retinal disease (Cohort 2) will be enrolled. Design: This is a longitudinal study protocol where participants will be imaged with investigational multimodal AO (mAO) retinal imaging systems that include ...

      Read Full Article
      Mentions: National Eye Institute

    7. U.S. FDA grants RetinAI Discovery 510(k) clearance

      Explore startupticker.ch News Startupticker.ch Ophthalmology , Clinical Trials
      U.S. FDA grants RetinAI Discovery 510(k) clearance

      RetinAI Medical AG received the U.S. Food and Drug Administration 510(k) clearance of RetinAI Discovery, paving the way for the startup to enter the U.S market. The image and data management platform enables next-level interoperability across the clinical and clinical study ecosystems in ophthalmology. Since 2017, RetinAI has been developing software solutions to accelerate clinics, research and pharmaceutical workflows globally using advanced machine learning and computer vision. The company builds tools to collect, organise and analyse health data from the eyes, enabling healthcare professionals and companies to make the right decisions sooner. The CE-mark certified platform, RetinAI ...

      Read Full Article
      Mentions: FDA RetinAI

    8. Coherent Optical Detection of Middle Ear Disease

      Explore Home - ClinicalTrials.gov Otolaryngology , Clinical Trials
      Coherent Optical Detection of Middle Ear Disease

      Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States, affects 90% of all children, and is the most common indication for antimicrobial therapy and surgery in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity. OM continues as the most common cause of hearing loss in children and leads to speech, educational and other developmental delays. OM causes life-threatening complications and is expensive, resulting in over $5 billion annually in U.S. health care expenditures. Despite the ...

      Read Full Article
      Mentions: University of Wisconsin National Institutes of Health University of Illinois at Urbana-Champaign

    9. Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

      Explore Home - ClinicalTrials.gov Dermatology , Oncology , Clinical Trials
      Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

      There are mainly 3 types of skin cancer: melanoma, basal cell carcinoma and squamous cell carcinoma. The diagnosis of skin cancers is now based on anatomo-pathological evidence. However, given the progress made, imaging is a technique that now has a full role in the diagnosis of these pathologies. This is particularly the case of confocal optical coherence tomography (LC-OCT), which is a recent imaging technique that has proven itself in ophthalmology with the obtaining of precise images of the retina. LC-OCT can be applied in dermatology according to the following principle: the low intensity laser beam delivered by the LC-OCT ...

      Read Full Article
      Mentions: Damae Medical

    10. Optical Coherence Tomography Angiography and Choroidal Osteoma

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Optical Coherence Tomography Angiography and Choroidal Osteoma

      The choroidal osteoma is a rare benign tumor of choroid, it is bilateral in 10%-25% of cases, affecting usually young women. Previous studies evaluated the morphologic characteristics of tumor-related vasculatures, described as a seafun vascular networks, but none focused on study of vessel density of coriocapillary. The aim of this study is to investigate the potential role of the optical coherence tomography angiography (OCTA) in evaluating the choriocapillary vessel density in order to individuate the changes of this vascular network that may influence the onset of choroidal neovasculariztion. Therefore, OCTA could be useful in the clinical management of the ...

      Read Full Article
      Mentions: University Federico II

    12. Optical Coherence Tomography Findings in Migraine

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Optical Coherence Tomography Findings in Migraine

      This study aims to detect changes in RNFL thickness in patients with different types of migraine in comparison to healthy control. This will be accomplished by comparing the optic nerve head (ONH) parameters, RNFL thickness, and ocular perfusion pressure (OPP) in migraine patients with age and sex matched healthy control.

      Read Full Article
      Mentions: World Health Organization

    13. Optical Coherence Tomography Angiography Compared to Maternal Doppler in Screening for Hypertension in Pregnancy

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Optical Coherence Tomography Angiography Compared to Maternal Doppler in Screening for Hypertension in Pregnancy

      Pregnancy related hypertension is one of the most prevalent obstetric complications. The aim of the study is to evaluate the validity and sensitivity of OCT angiography in prediction of pregnancy induced hypertensive disorders in comparison to maternal doppler in the first and second trimesters of pregnancy

      Read Full Article

    14. Evaluating Home Testing Devices for the Management of Glaucoma

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Evaluating Home Testing Devices for the Management of Glaucoma

      Standard Automatic Perimetry (SAP) is the gold standard test for evaluation of diseases of the visual pathway like glaucoma. Its main goal is to measure differential light sensitivity at several locations in the field of vision. Several devices have been developed since the advent of the Octopus Perimeter and the Humphrey Field Analyzer (HFA) is now the most commonly used machine for checking the visual field. These devices have a number of disadvantages including being stressful for debilitated, ill, or elderly patients to keep their heads still in the perimeter bowl during the test. Recently, several methods have been introduced ...

      Read Full Article

    15. New Imaging Procedures and Therapeutic Approach in Basal Cell Carcinoma Management

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      New Imaging Procedures and Therapeutic Approach in Basal Cell Carcinoma Management

      The aim of this study is to show that the Nd:YAG laser could be a promising alternative treatment option in the management of low-risk basal cell carcinomas with similar high efficacy rates to surgery, and low recurrence rates evaluated over a time period of one year. Reflectance confocal microscopy, optical coherence tomography and clinical examination are used prior to confirm the clinical diagnosis of the basal cell carcinoma and for premargination of the tumor. The optical coherence tomography will also be used post treatment to confirm clearance of the basal cell carcinoma and to monitor treatment response

      Read Full Article
      Mentions: Medical University of Vienna

    16. Ocular Surface Disease and IOP Monitoring With Travoprost Without Conservatives

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Ocular Surface Disease and IOP Monitoring With Travoprost Without Conservatives

      This is a prospective study including patients visiting the outpatient glaucoma clinic of the University General Hospital of Alexandroupolis for their standard evaluation. Study population is already under treatment with a travoprost preparation without preservatives. They will be fully informed about the procedure and the purpose of the study and a written consent will be obtained. For every patient included in the study intraocular pressure will be measured using a Goldman applanation tonometer, according to the standard way of practice at our clinic. Also, Tear Break-Up-Time (BUT), conjunctival hyperemia grading and Schirmer testing will be used to assess the ocular ...

      Read Full Article

    17. RETRIEVE - AMI Study

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      RETRIEVE - AMI Study

      Heart attacks are caused by the sudden formation of a clot inside a diseased coronary artery which reduces blood flow beyond the blockage site. During conventional treatment of the blockage with what is known as a stent; a stainless steel tub that keeps the artery open, the clot that has formed is disrupted and is pushed further down leading to damage in smaller blood vessels supplying the heart muscle. This additional damage can lead to long-term heart muscle damage influencing recovery and wellbeing. The original concept that was tested to prevent this 'clot shower' was that of a suction device ...

      Read Full Article

    18. Clinical Study - Es 900 - 2020-1

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Clinical Study - Es 900 - 2020-1

      EYESTAR 900 is a device developed by Haag-Streit which utilises 3D OCT for quantitative measurements of the geometry of the entire eye, including ocular biometry and corneal topography. It is the most recent in a series of successful biometry devices by Haag-Streit (HS Pachymeter, Lenstar LS 900, LS 900 T-cone and LS 900 APS) and also allows for advanced corneal tomography examinations. The EYESTAR 900 is CE marked. These measurement results of this device are used for the planning of the medical treatment of patients. Depending on the application, the benefits of this device may include improved visual acuity (after ...

      Read Full Article
      Mentions: Haag-Streit

    19. NA-AION Risk Factors: New Perspectives

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      NA-AION Risk Factors: New Perspectives

      Non-arteritic anterior ischemic optic neuropathy (NA-AION) is the most common acute optic neuropathy in the middle-aged and elderly population and can also occur in children and young adults. NA-AION leads to irreversible vision loss, and there is currently no effective treatment. In recent years, acellular calcified deposits in the optic nerve head called optic disc drusen (ODD) have been investigated as an important risk factor for NA-AION in patients under the age of 50. The purpose of the study is to use new diagnostic methods optical coherence tomography (OCT) and OCT-angiography (OCTA) to shed light on risk factors for the ...

      Read Full Article
      Mentions: Stanford University University of Copenhagen University of Utah

    20. CAlcified Lesion Intervention Planning Steered by OCT.

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      CAlcified Lesion Intervention Planning Steered by OCT.

      Calcified lesions are very frequent among coronary artery disease stenotic lesions. The prevalence of calcifications ranges from 30 to 40% (by angiography evaluation) but is higher when analyzed by intra coronary imaging. Calcified lesions are very frequent among coronary artery disease stenotic lesions. The prevalence of calcifications ranges from 30 to 40% (by angiography evaluation) but is higher when analyzed by intra coronary imaging. The presence of calcifications increases the risk of adverse evolution after PCI , including stent restenosis, thrombosis and need for repeat revascularisation. Specific and appropriate tools can be used for calcified lesions management , including high pressure non ...

      Read Full Article
      Mentions: Abbott

    21. A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optimal Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optimal Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

      The purpose of this study is to find out if radiation therapy (RT) guided by the new reflectance confocal microscopy (RCM)/optimal coherence tomography (OCT) device is an effective treatment for basal cell carcinoma (BCC). The researchers will also look at the side effects from RT guided by the RCM/OCT device. In addition, will determine the quality of life before and after treatment by having the participant fill out questionnaires.

      Read Full Article
      Mentions: Physical Sciences Incorporated

    22. Optical Coherence Tomography Angiography (OCTA) Changes in Patients With Epiretinal Membranes (ERM) With and Without Peeling of the Internal Limiting Membrane (ILM)

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Optical Coherence Tomography Angiography (OCTA) Changes in Patients With Epiretinal Membranes (ERM) With and Without Peeling of the Internal Limiting Membrane (ILM)

      Main objective The objective is to compare two surgical options in vitrectomies for epiretinal membranes using parameters of optical coherence tomography angiography. Background State of the art treatment for epiretinal membranes consists of pars plana vitrectomy, staining of the epiretinal membrane with a blue colouring dye and epiretinal membrane peeling. The vitrectomized space is filled with fluid (balanced salt solution) during the procedure and the fluid can optionally be replaced with air as a final step. After ERM peeling (but before the selection of the tamponade), the internal limiting membrane (the innermost layer of the retina) is either peeled as ...

      Read Full Article

    23. Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries (CMD-MINOCA)

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries (CMD-MINOCA)

      To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and non-invasive coronary physiologic assessment.

      Read Full Article
      Mentions: Abbott
    1-24 of 617 1 2 3 4 ... 24 25 26 »
  1. Search:

  2. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology

    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents

    3. Technology:

      Broadband Sources, Probes, Tunable Sources

    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks

  4. Popular Articles

  5. Organizations in the News

    1. (1 articles) The Chinese University of Hong Kong
    2. (1 articles) University of Cambridge
    3. (1 articles) University of Bologna