Clinical Trials -Optical Coherence Tomography News

Articles in category: Clinical Trials

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1. Simultaneous OCT and B-FAF in Eyes With Alteration of the Foveal Contour
  
  Explore Home - ClinicalTrials.gov Sep 21 2017 Ophthalmology , Clinical Trials
  
  Some alterations of the foveal contour do not meet the criteria established for the definition of lamellar macular hole on the basis of optical coherence tomography (OCT). However, these alterations may show an appearance, on blue fundus autofluorescence (B-FAF) imaging, reminiscent of lamellar macular hole. The aim of the study is to evaluate in detail these alterations recording simultaneously OCT and B-FAF.
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  Mentions: University of Milan
2. Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging
  
  Explore Home - ClinicalTrials.gov Aug 25 2017 Ophthalmology , Clinical Trials
  
  The aim of this pilot study is to assess the ability of a new polarization sensitive optical coherence tomography system to obtain high-quality images of retinal birefringence. Glaucoma is the second leading cause of blindness in the world. The current clinical standard-of-care procedure to diagnose glaucoma is visual field testing with disc photography. Visual field testing is subjective both in the patient's feedback and the physician's interpretation of this feedback, and disc photography requires a physician's subjective interpretation. As a result, it is estimated that current methods can diagnose glaucoma only after 40% of the nerve fiber ...
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  Mentions: Massachusetts General Hospital Harvard University Benjamin J. Vakoc
3. Evaluation of Retinal Microstructure Detected With Intraoperative Optical Coherence Tomography During Vitrectomy
  
  Explore Home - ClinicalTrials.gov Aug 10 2017 Ophthalmology , Clinical Trials
  
  We evaluate the intraoperative optical coherence tomographic (OCT) images of eyes with idiopathic macular hole (MH) or lamellar macular hole whether the intraoperative OCT findings will affect postoperative visual outcome.
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  Mentions: Kyorin University
4. OCT in Borderline Coronary Artery Lesions (OCT-borderline)
  
  Explore Home - ClinicalTrials.gov Jul 30 2017 Cardiology , Clinical Trials
  
  To find out the safety and efficacy of Optical Coherence Tomography (OCT) in the evaluation and treatment of angiographically borderline coronary artery lesions in a Chinese population, and to compare the effectiveness of OCT versus SPECT in treating such subjects. All patients included in the study will be those that are found to have borderline coronary artery lesions on coronary angiography, in whom we feel that OCT will be useful to assess whether PCI will be of benefit to the treatment of the lesion pathology, or whether optimal medical therapy is the most appropriate treatment modality. Those patients who declined ...
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5. Optical Coherence Tomography (OCT) Findings and Coronary Bifurcation Lesions
  
  Explore Home - ClinicalTrials.gov Jun 3 2017 Cardiology , Clinical Trials
  
  To determine the clinical relevance of vulnerable plaque using OCT in patients with coronary bifurcation lesion.
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6. The OCTOBER Trial - Nordic-Baltic-British Study on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)
  
  Explore Home - ClinicalTrials.gov Jun 1 2017 Cardiology , Clinical Trials
  
  The purpose is to compare median two-year clinical outcome after OCT guided vs. standard guided revascularization of patients requiring complex bifurcation stent implantation
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7. Optical Coherence Tomography in Acute Coronary Syndrome (OPTICO-ACS)
  
  Explore Home - ClinicalTrials.gov Apr 29 2017 Cardiology , Clinical Trials
  
  The OPTICO-ACS- study program - combining for the first time in vivo characterization of the ACS-causing "culprit lesion" by intracoronary imaging technique with optical coherence tomography (OCT) and molecular analysis of immune-cells derived from the culprit coronary thrombus and biochemical analyses in patients with acute-coronary-syndrome (ACS).
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8. Pituitary Gland Enlargement Was First Diagnosed by Optical Coherence Tomography (OCT)
  
  Explore Home - ClinicalTrials.gov Mar 24 2017 Clinical Trials
  
  OCT is now an established way to measure the thickness of the Retinal Nerve Fiber Layer (RNFL) in the retina of the eye. The thickness of the RNFL is always a reflection of the number of the RNFs in any particular area of the retina. Each single RNF runs a long course starting from the cell body which is the retinal ganglion cell in the retina and ends in the thalamus of the brain where it relays visual information to other nerve cell in the thalamus. Along this long course RNFs are in close anatomical relationship with the pituitary gland ...
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9. Comparisons of Morphological Measurement Between Coronary Computed Tomography and Optical Coherence Tomography
  
  Explore Home - ClinicalTrials.gov Jan 13 2017 Cardiology , Clinical Trials
  
  The objective of this study is to evaluate the precision of semi-automated lumen boundary identification from coronary computed tomography angiography (cCTA) by current version of HeartFlow software and the impact on fractional flow reserve (FFRCT) by using optical coherence tomography (OCT) as reference standard.
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  Mentions: Kobe University Graduate School of Medicine Hiromasa Otake
10. Optical Coherence Tomography Morphologic and Fractional Flow Reserve Assessment in Diabetes Mellitus Patients (COMBINE)
  
  Explore Home - ClinicalTrials.gov Dec 12 2016 Cardiology , Clinical Trials
  
  Combined Optical Coherence Tomography Morphologic and Fractional Flow Reserve Hemodynamic Assessment of Non-Culprit Lesions to Better Predict Adverse Event Outcomes in Diabetes Mellitus Patients COMBINE (OCT-FFR) Prospective Register To study the natural evolution of patients with at least one intermediate angiographic but non-hemodynamic significant stenotic lesion, in two subgroups of patients, with TCFA vs. no TCFA as detected by OCT imaging and to compare these two groups of patients with each other as well as to a subset of patients with FFR-positive and PCI-treated intermediate lesions on future MACE.
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11. Comparison Between an Electronic Mobile Device and Optical Coherence Tomography to Determine Cup-to-disc Ratio
  
  Explore Home - ClinicalTrials.gov Dec 10 2016 Ophthalmology , Clinical Trials
  
  his study was a non-inferiority trial with masked data analysis. Individuals ranging from 18 to 60 years from both genders that met the pre-defined criteria were included. This study was carried out in Recife at Clinica Oftalmologica Zona Sul and at Centro de Informatica-UFPE. Using both equipment, 5 vertical cup-to-disc ratio (VCDR) evaluations were performed for each eye of the individuals, under midriatic conditions. Evaluations were done by examiners who did not know previously results obtained from other equipment. Data was collected by the main researcher of this research. This study was approved by the ethics committee before it started ...
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12. Optical Coherence Tomography (OCT) Intravascular Ultrasound (IVUS) Dual Imaging
  
  Explore Home - ClinicalTrials.gov Dec 7 2016 Cardiology , Clinical Trials
  
  Both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are standardly used and have been extensively studied separately to guide percutaneous coronary intervention and improve long-term outcomes. In this study, the investigators aim to directly compare high-definition IVUS images to OCT in the same patients to determine the differences between each modality as they relate to imaging coronary pathology, with the goal of determining which modality is most appropriate in particular clinical scenarios.
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  Mentions: Columbia University
13. Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study
  
  Explore BMJ Open Dec 1 2016 Cardiology , Clinical Trials
  
  Introduction The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. While this procedure has revolutionised treatment, the incidence of secondary events remains a concern. These repeat events are thought to be due, in part, to continued enhanced platelet reactivity, endothelial dysfunction and ultimately restenosis of the stented artery. In this study, we will investigate whether a once a day inorganic nitrate administration might favourably modulate platelet reactivity and endothelial function leading to a decrease in restenosis. Methods and design NITRATE-OCT is ...
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  Mentions: Imperial College London
14. Korea University Anam Hospital Optical Coherence Tomography Registry
  
  Explore Home - ClinicalTrials.gov Nov 19 2016 Cardiology , Clinical Trials
  
  All comer registry who had undergone intravascular optical coherence tomography during and/or after coronary intervention.
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  Mentions: Korea University
15. Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography
  
  Explore Home - ClinicalTrials.gov Sep 21 2016 Ophthalmology , Clinical Trials
  
  Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from ...
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16. Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)
  
  Explore Home - ClinicalTrials.gov Sep 21 2016 Ophthalmology , Clinical Trials
  
  This is a 3-year, pharmacologically non-interventional study to evaluate OCT as an outcome measure in patients with relapsing remitting multiple sclerosis (RRMS). Approximately 350 RRMS patients, either untreated or treated with an approved MS disease-modifying therapy and approximately 70 reference subjects without ophthalmologic or neurologic disease are enrolled. No study medications are provided. Patients on disease-modifying therapy are treated according to the local prescribing information. For each MS patient and each reference subject, the study consists of Screening (up to 1 month), Baseline, and a 36-month longitudinal data collection phase. Eligibility will be confirmed during Screening.
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17. Clinical Significance of Pre-interventional Optical Coherence Tomography in Bioresorbable Vascular Scaffold Implantation
  
  Explore Home - ClinicalTrials.gov Sep 13 2016 Cardiology , Clinical Trials
  
  Previous studies reported 20-30% of under-expansion or malapposition with BVS, which would increase the risk of adverse events including late stent thrombosis. OCT-guidance may improve more optimized scaffold placement and also better outcomes. However, there is still no sufficient evidence that OCT has an inevitable role in optimal implantation of BVS and it should be more evaluated in real practice. In the study, the investigators will evaluate an incidence of OCT-defined BVS sub-optimization requiring additional PCI+A1.
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  Mentions: Yonsei University Myeong-Ki Hong
18. Optical Tomographic Scanner for Skin Lesions
  
  Explore Home - ClinicalTrials.gov Sep 8 2016 Dermatology , Clinical Trials
  
  Optical coherence tomography is technology widely used in medicine. In this study, we will use an optical tomographic scanner to scan skin tissue image.
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  Mentions: National Taiwan University Jeng-wei Tjiu
19. OCT Based Edge and In-stent Vascular Response After Cordimax Stent in patIents With NSTE-ACS
  
  Explore Home - ClinicalTrials.gov Aug 11 2016 Cardiology , Clinical Trials
  
  This study evaluates the completeness of strut coverage and vessel wall response, at different time points (3-6-12 Months), following CordimaxTM stent implantation in patients with non-ST elevation acute coronary syndrome
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20. The Impact of Two Strategies in the Monitoring of Exudative ARMD on the Visual Acuity (by OCT B Scan or OCT Angiography)
  
  Explore Home - ClinicalTrials.gov Aug 11 2016 Ophthalmology , Clinical Trials
  
  The treatment of neovascular age-related macular degeneration (ARMD) is a major issue of public health. The therapeutic arsenal has widely grown throughout the years with the emergence of intra-vitreous anti-angiogenic treatments, under different surveillance protocols. The "PRN" surveillance (pro re nata: an on-demand treatment with monthly follow-up) allows a faster re-injection in case of neovascular relapse in order to maintain the best visual acuity. This therapeutic protocol is guided by the sub-retinal neovascular signs of activity. The monitoring is done during common practice via OCT B scans showing indirect signs of neovascular activity (exudation signs). OCT retinal imaging has been ...
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21. 6-month Intracoronary Optical Coherence Tomography (OCT) Evaluation of Three New Generation Drug Eluting Stent (CREBX-OCT)
  
  Explore Home - ClinicalTrials.gov Aug 2 2016 Cardiology , Clinical Trials
  
  Aim of this study is to compare at 6 months follow-up, endothelization and malapposition, evaluated by means of optical coherence tomography, in terms of number of struts not endothelized or malapposed, after the implantation of three new generation stent: Cre8, Biomatrix and Xience.
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22. Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. (OCT)
  
  Explore Home - ClinicalTrials.gov Jul 31 2016 Ophthalmology , Clinical Trials
  
  The primary aim of the study is to investigate whether optical coherence tomography (OCT) may be a useful tool for investigating the in-vivo histology of ocular structures in patients with tear film pathology. In epiphora the investigators will image the proximal lacrimal system. In dry eye syndrome the investigators will image the lacrimal gland and also the buccal mucosa. The secondary aim of the study is to investigate the appearance of the normal cornea and conjunctiva under OCT imaging.
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23. Study of Imaging Characteristics OCT of Skin Lesions Requiring Biopsy / Resection (OCTSKIN)
  
  Explore Home - ClinicalTrials.gov Jul 28 2016 Dermatology , Oncology , Clinical Trials
  
  The diagnosis of cutaneous lesions often involves the use of surgical and invasive procedures such as biopsy or excision in order to analyze the structure and appearance of the fabric pathologists. With recent advances in optical and electronic fields, considerable efforts were produced to build high-performance optical instruments, able to transcribe the internal structure of the skin with varying degrees of depth and variable resolution. The imagery is now an area of great interest for medical diagnosis: non-invasive, quick, and in real time. This area is booming and new optical instruments are created to eventually be able to offer a ...
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24. The Effect of Oral Contraceptive Pills On Eyes
  
  Explore Home - ClinicalTrials.gov Jul 14 2016 Ophthalmology , Clinical Trials
  
  The investigators aimed to evaluate the effect of oral contraceptive pills(OCP) on macula, retinal nerve fiber layer and choroid thickness by using Optical Coherence Tomography (OCT). The present clinical study is the first research reported in the literature which is investigating the posterior ocular segment changes in women using OCP by using OCT.
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