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Laser treatment of cutaneous vascular lesions
Explore Article uspto.gov (Sep 13 2005)
Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion. Blood flow velocity is slowed within the region using the hyperosmotic agent, and the lesion is exposed to laser radiation.Comment on Article Mentions: University of Texas at Austin Jennifer K. Barton Ashley J. Welch
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Estimation of nonlinear mechanical properties of atherosclerotic plaques (Thesis)
Explore Article DSpace@MIT (Sep 1 2005)
A numerical method has been developed to estimate the mechanical properties of atherosclerotic plaques by combining genetic algorithm with finite element methods. Plaque images derived from optical coherence tomography were employed to construct finite element models which were subsequently used in conjunction with a genetic algorithm to determine the parameters in a nonlinear constitutive model. A new multi-frame scheme is introduced to better perform the estimation on a nonlinear mechanical model and reduce the effects of noise. Results show while it is feasible to estimate the nonlinear mechanical properties of plaque, the accuracy can depend on various factors, especially the ...
Comment on Article Mentions: Massachusetts Institute of Technology
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Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models
Explore Article SPIE Digital Library (Jul 15 2005)
We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.Comment on Article Mentions: Yueli Chen University of Connecticut Quing Zhu
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Coating for implantable devices and a method of forming the same
Explore Article uspto.gov (Jun 21 2005)
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.Comment on Article Mentions: Advanced Cardiovascular Systems
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Stent for treating vulnerable plaque
Explore Article uspto.gov (May 31 2005)
An intravascular stent is configured for asymmetrical differential deployment and to align with a fibrous cap to treat vulnerable plaque. The stent is configured so that reduced expansion forces are imparted during deployment to the fibrous cap, thereby reducing the likelihood of cap rupture. The stent includes cylindrical rings connected by links and a cover attached to a portion of the stent to differentially restrict stent expansion when the stent is expanded from a delivery diameter to an implanted diameter thereby creating asymmetrical circumferential deployment. The portion of the stent having the cover imparts lower expansion forces from the stent ...Comment on Article Mentions: Advanced Cardiovascular Systems
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Fluid exchange system for controlled and localized irrigation and aspiration
Explore Article uspto.gov (Apr 12 2005)
The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically controlled ...Comment on Article Mentions: FoxHollow Technologies ev3 Brian K. Courtney
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Medical scanning system and related method of scanning
Explore Article uspto.gov (Mar 29 2005)
The present invention is directed to a scanning system that uses uniform rotary motion of an optical reflector to create reciprocal linear scanning. The system converts uniform rotation into uniform longitudinal scanning. The system thereby creates mechanical reciprocal linear scanning free of reciprocally moving mechanical parts common in conventional scanning systems. In a preferred embodiment of the invention, the scanning system is incorporated within an imaging catheter for medical scanning. The optical reflector is rotatable and includes a spiral reflecting portion. The spiral reflecting portion may be a single uniform reflecting surface or may include several reflection surfaces arranged in ...Comment on Article Mentions: Boston Scientific
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Catheter with protective sleeve
Explore Article uspto.gov (Dec 14 2004)
A device for accessing the spinal canal of a patient includes an introducer and a protective sleeve that is attached at one end thereof to a proximal end of the introducer. The protective sleeve has an outer stationary portion and an inner moveable portion. The outer and inner portions of the protective sleeve are separated by a crown region. A catheter is disposed inside the protective sleeve. During operation, the protective sleeve is advanced within the spinal canal to form a protective barrier between the catheter and the spinal cord. The catheter is advanced and retracted within the protective sleeve.Comment on Article Mentions: Boston Scientific
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Fluid exchange system for controlled and localized irrigation and aspiration
Explore Article uspto.gov (Dec 7 2004)
The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically controlled ...Comment on Article Mentions: FoxHollow Technologies ev3 Brian K. Courtney
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Methods and apparatus for in vivo identification and characterization of vulnerable atherosclerotic plaques
Explore Article uspto.gov (Nov 9 2004)
Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric ... -
Coating for implantable devices and a method of forming the same
Explore Article uspto.gov (Sep 4 2004)
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.Comment on Article Mentions: Advanced Cardiovascular Systems
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Elastography of coronary vessels using optical coherence tomography (Thesis)
Explore Article DSpace@MIT (Sep 1 2004)
Atherosclerosis is an inflammatory disease characterized by an accumulation of lipid and fibrous tissue in the arterial wall. Postmortem studies have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid=rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex vivo plaque geometry have found that most plaques rupture at sites of high circumferential stress, thus diagnosis of plaque vulnerability may be enhanced by probing the mechanical behavior of individual plaques. Elastrography is a method of strain imaging in which an image sequence of the artery undergoing deformation is acquired, pixel motion ...
Comment on Article Mentions: Brett E. Bouma Massachusetts Institute of Technology Massachusetts General Hospital
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Methods and apparatus for characterizing lesions in blood vessels and other body lumens
Explore Article uspto.gov (Aug 24 2004)
Methods, devices, and kits, for assessing luminal lesions are provided. The subject devices comprise an intraluminal detector capable of sensing radioactive or other labels. In the subject methods, a detectable marker is introduced to a body lumen, either into the lumen itself or systemically in patient circulation, and localizes at a lesion. The detector is introduced into the body lumen and the distribution of a localized marker detected in situ. The information is useful for a number of purposes including the identification of unstable plaque in patients suffering from atherosclerotic disease.Comment on Article Mentions: Stanford University
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Method and apparatus for detecting vulnerable atherosclerotic plaque
Explore Article uspto.gov (Jul 13 2004)
Methods and devices are disclosed for detecting vulnerable atherosclerotic plaque, or plaque at risk of reducing blood flow in a vessel, by a identifying a region of elevated temperature along a living vessel wall. The disclosure that human atherosclerotic plaque with measurable temperature heterogeneity has the morphological characteristics of plaque that is likely to ulcerate provides a new and sensitive technique for detecting and treating these dangerous plaques before myocardial infarction and its consequences occur. The disclosed methods are advantageous over conventional plaque detection techniques because they are capable of differentiating between those plaques that are at great risk of ... -
Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation
Explore Article uspto.gov (Jun 29 2004)
Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
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Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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