1. Articles in category: Cardiology

    49-72 of 3909 « 1 2 3 4 5 6 ... 161 162 163 »
    1. Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe

      Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe

      Objectives This study sought to investigate the potential of the noninvasive albumin-binding probe gadofosveset-enhanced cardiac magnetic resonance (GE-CMR) for detection of coronary plaques that can cause acute coronary syndromes (ACS). Background ACS are frequently caused by rupture or erosion of coronary plaques that initially do not cause hemodynamically significant stenosis and are therefore not detected by invasive x-ray coronary angiography (XCA). Methods A total of 25 patients with ACS or symptoms of stable coronary artery disease underwent GE-CMR, clinically indicated XCA, and optical coherence tomography (OCT) within 24 h. GE-CMR was performed approximately 24 h following a 1-time application of ...

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    2. Optical coherence tomography guided directional atherectomy with anti-restenotic therapy for femoropopliteal arterial disease

      Optical coherence tomography guided directional atherectomy with anti-restenotic therapy for femoropopliteal arterial disease

      BACKGROUND: Optical coherence tomography (OCT)-guided directional atherectomy enables a real-time visualization of the arterial wall during plaque debulking and might optimize vessel preparation prior to DCB angioplasty. Nonetheless there is a paucity of data reporting on the outcomes of OCT-guided directional atherectomy with anti-restenotic therapy (DAART). Aim of this study was to evaluate the performance of OCT-guided DAART in the treatment of femoropopliteal atherosclerosis. METHODS: Patients treated by OCT-guided DAART for femoropopliteal occlusive disease between January 2015 and December 2016 were included into this retrospective, single center, single-arm analysis. The primary measure outcome of this study was primary patency ...

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    3. Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives 2019 NIH Grant for $165,376 for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology. The principal investigator is Eric Osborn. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Dr. Eric Osborn is an early career faculty member at Beth Israel Deaconess Medical Center (BIDMC) and Massachusetts General Hospital (MGH), and an Instructor in Medicine at Harvard Medical School, Boston, Massachusetts. He is a graduate of the MD-PhD program at Harvard Medical School and Massachusetts Institute of Technology, and has completed clinical training in medicine and ...

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    4. The safety of renal denervation as assessed by optical coherence tomography: pre- and post-procedure comparison with multi-electrode ablation catheter in animal experiment

      The safety of renal denervation as assessed by optical coherence tomography: pre- and post-procedure comparison with multi-electrode ablation catheter in animal experiment

      Objective Prove the effectiveness and safety of multi-electrode ablation catheter in renal denervation (RDN) by optical coherence tomography (OCT). Methods 16 renal arteries were enrolled from 8 pigs. Angiography and OCT were used to obtain the morphology changes before RDN and 1-month follow-up. Blood pressure and creatinine were tested to prove the effectiveness and safety of the catheter. Results 1 renal artery was excluded because of the small diameter. 15 renal arteries were successfully preformed renal denervation and OCT. Mean blood pressure was significantly reduced 1 month after RDN (122.40±3.54mmHg vs 106.50±2.06mmHg, n=8 ...

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    5. Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography

      Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography

      Defects of the mitral valve complex imply heart malfunction. The chordae tendineae (CTs) are tendinous strands connecting the mitral and tricuspid valve leaflets to the papillary muscles. These CTs are composed of organized, wavy collagen bundles, making them a strongly birefringent material. Disorder of the collagen structure due to different diseases (rheumatic, degenerative) implies the loss or reduction of tissue birefringence able to be characterized with Polarization Sensitive Optical Coherence Tomography (PS-OCT). PS-OCT is used to discriminate healthy from diseased chords, as the latter must be excised and replaced in clinical conventional interventions. PS-OCT allows to quantify birefringence reduction in ...

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    6. Heart Failure After Heart Transplantation Due to Chronic Rejection

      Heart Failure After Heart Transplantation Due to Chronic Rejection

      During long-term follow-up heart transplant recipients are at risk of developing different complications that are likely to affect quality of life and survival. The most common cause of death during the later stages after heart transplantation is cardiac allograft vasculopathy, followed by unexplained graft dysfunction. In this study, advanced imaging techniques will be used to describe the frequency of these two complications, examine possible risk factors and study consequences on functional capacity and quality of life. Further, the investigators will investigate whether it is feasible to screen for these conditions with non-invasive imaging methods. By studying patients that have performed ...

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    7. Optical coherence tomography and C-reactive protein in risk stratification of acute coronary syndromes

      Optical coherence tomography and C-reactive protein in risk stratification of acute coronary syndromes

      Background Patients with acute coronary syndrome (ACS) associated to high C-reactive protein (CRP) levels exhibit a higher risk of future acute ischemic events. Yet, the positive predictive value of CRP is too low to guide a specific treatment. Our study aims to identify a high-risk patient subset who might mostly benefit from anti-inflammatory treatment on the basis of the combination of optical coherence tomography (OCT) assessment of the culprit vessel and CRP serum levels. Methods Patients admitted for ACS and undergoing pre-interventional OCT assessment of the culprit vessel were selected from “Agostino Gemelli” Hospital OCT Registry. The primary end-point was ...

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    8. A case of severely calcified neoatherosclerosis-embedded stent struts clearly documented with optical coherence tomography imaging

      A case of severely calcified neoatherosclerosis-embedded stent struts clearly documented with optical coherence tomography imaging

      A 65-year-old Japanese man using peritoneal hemodialysis due to diabetic nephropathy underwent a planned coronary angiography as a preoperative examination. Fourteen years earlier, he had undergone a percutaneous coronary intervention due to acute myocardial infarction and had been implanted with a bare-metal stent in the left anterior descending coronary artery. Although his condition had run a benign course without any recurrence of cardiovascular events, coronary angiography was performed 14 years later in preparation for a living-donor kidney transplantation. Coronary angiography revealed less than 50% restenosis (Figure A). Although Figure B indicates circumferentially covered stent struts, the homogeneous neointima pattern observed ...

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    9. Updates on PCI Guidelines and Trials From the European Society of Cardiology (ESC) Congress

      Updates on PCI Guidelines and Trials From the European Society of Cardiology (ESC) Congress

      Radial Access and Provisional T-Stenting Preferred for PCI: Another important procedural recommendation from the ESC was that radial access should be the preferred approach for coronary angiography and PCI (class I recommendation). While this approach has been a standard for many years in the European communities, it has now been codified as part of the ESC guidelines and may one day be part of the ACC/SCAI guidelines. For those addressing bifurcations with stenting, the ESC/EACTS guidelines upgraded provisional T-stenting for bifurcation lesions from class IIa to class I, and upgraded the use of optical coherence tomography (OCT) for ...

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    10. Diagnosis and treatment evaluation of in-stent restenosis of carotid artery stenting using optical coherence tomography

      Diagnosis and treatment evaluation of in-stent restenosis of carotid artery stenting using optical coherence tomography

      A 65-year-old man underwent balloon angioplasty and repeat carotid artery stenting (CAS) due to in-stent restenosis (ISR). Intravascular optical coherence tomography (OCT) showed a severe ISR with fibrotic neointimal growth ( figure 1 ). Post 6.0 × 30 mm balloon angioplasty, OCT showed intimal disruption and artery dissection ( figure 2 ). After the 8 × 40 mm stent fully expanded, OCT showed stent struts well apposed, but tissue protrusion from the spaces between stent struts can be observed ( figure 2 ). OCT allowed measurement of intimal hyperplasia after the CAS and observation of intimal disruption and stent strut apposition intraoperatively. 1 , 2

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    11. Association Between IVUS and OCT Parameters and Invasive Physiologic Indices

      Association Between IVUS and OCT Parameters and Invasive Physiologic Indices

      Given the inherent limitations of coronary angiography to depict the presence of functionally significant epicardial coronary stenosis and discrepancy between angiographic stenosis severity and the presence of myocardial ischemia, invasive physiologic indices such as fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) has been a standard method to guide decision of revascularization. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are an intracoronary imaging method able to provide information about lumen area, vessel area, plaque burden, and plaque characteristics that can be used for the guidance of revascularization procedure. Several previous studies explored the diagnostic performance of intravascular imaging-defined ...

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    12. Feasibility of a porcine arteriovenous shunt model for assessment of acute thrombogenicity in bifurcation stenting technique by optical coherence tomography

      Feasibility of a porcine arteriovenous shunt model for assessment of acute thrombogenicity in bifurcation stenting technique by optical coherence tomography

      Background Double kissing (DK) crush stenting has been reported as a superior bifurcation stenting strategy compared to culotte stenting. However, the mechanism associated with the reduction of clinical events by DK crush stenting remains unclear. We therefore investigated the thrombogenicity of DK crush stenting and culotte stenting with both bare-metal stents (BMS) and drug-eluting stents (DES) and the feasibility of a novel porcine arteriovenous shunt model. Methods High-resolution intracoronary imaging with optical coherence tomography (OCT) evaluated the bifurcation stenting models for thrombogenicity. Results All porcine models retained continuous circulation without blood leakage. Thrombus was macroscopically demonstrated around the bifurcation in ...

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    13. MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.

      MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.

      Massachusetts General Hospital Receives a 2019 NIH Grant for $729,778 for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management. The principal investigator is Guillermo Tearney. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. Management of CAD is hindered by our inability to investigate fundamental pathobiologic processes that lead to individual coronary plaque progression, destabilization, and adverse clinical events. A critical mechanism responsible for plaque behavior is local endothelial shear stress (ESS), the frictional force of blood flowing across the endothelium, which is governed by the artery’s ...

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    14. Optical Coherence Tomography Evaluation of Coronary Dissection and Intramural Hematoma

      Optical Coherence Tomography Evaluation of Coronary Dissection and Intramural Hematoma

      A 32-year-old female with elevated body mass index and no prior medical history presented with acute-onset central chest pain radiating to both arms. Electrocardiogram showed biphasic T-waves in the anterior leads and troponin level was elevated. Echocardiogram demonstrated preserved left ventricular function and no valvular abnormality. A diagnosis of non-ST elevation myocardial infarction (NSTEMI) was made. Coronary angiography revealed a smooth tapering stenosis in the mid left anterior descending (LAD) artery (Video 1), but no significant disease beyond (Figure 1, top center panel). The other coronary vessels were free of significant disease. Given her age and the somewhat unusual angiographic ...

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    15. Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial)

      Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial)

      Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is used for treating coronary lesions. However, the natural history of the jailed side-branch (SB) after DREAMS 2G implantation remains to be elucidated. The aim of this study is to investigate the effect of scaffold struts on jailed SBs as assessed by 3-dimensional (3D) optical coherence tomography (OCT) after implantation of DREAMS 2G. We enrolled the patients who received a DREAMS 2G implantation and where OCT was performed at post-procedure and 12-month follow-up in the BIOSOLVE-II trial. The area of the ostium of jailed SBs and number of compartments divided by scaffold struts ...

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    16. Fully Automated Lumen Segmentation Method for Intracoronary Optical Coherence Tomography

      Fully Automated Lumen Segmentation Method for Intracoronary Optical Coherence Tomography

      Background . Optical coherence tomography (OCT) is an innovative imaging technique that generates high-resolution intracoronary images. In the last few years, the need for more precise analysis regarding coronary artery disease to achieve optimal treatment has made intravascular imaging an area of primary importance in interventional cardiology. One of the main challenges in OCT image analysis is the accurate detection of lumen which is significant for the further prognosis. Method . In this research, we present a new approach to the segmentation of lumen in OCT images. The proposed work is focused on designing an efficient automatic algorithm containing the following steps ...

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    17. The relation between optical coherence tomography-detected layered pattern and acute side branch occlusion after provisional stenting of coronary bifurcation lesions

      The relation between optical coherence tomography-detected layered pattern and acute side branch occlusion after provisional stenting of coronary bifurcation lesions

      Background/Purpose. Layered pattern (presumed to be healed plaque after a thrombotic event) can be observed by optical coherence tomography (OCT). We sought to assess the ability of OCT-detected plaque composition to predict acute side branch (SB) occlusion after provisional bifurcation stenting. Methods This is a retrospective observational study using pre-intervention OCT in the main vessel to predict Thrombolysis in Myocardial Infarction (TIMI) flow grade ≤ 1 in a SB (diameter ≥ 1.5 mm) after provisional bifurcation stenting. OCT-detected layered pattern was defined as plaque with a superficial layer that had a different optical intensity and a clear demarcation from underlying ...

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    18. Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis

      Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis

      Aims Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is an alternative novel device for treating coronary lesions. However, the relationship between in-scaffold dimensions after implantation of DREAMS 2G and vessel healing and luminal results at follow-up is unknown. The aim of this study is, therefore, to investigate whether the expansion index after implantation of DREAMS 2G as assessed by optical coherence tomography (OCT) impacts late luminal status and healing of the vessel wall. Methods and results This study comprises of a total 65 out of 123 patients who were enrolled in the BIOSOLVE-II trial. We assessed both qualitative and quantitative ...

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    19. Zero contrast optical coherence tomography–guided percutaneous coronary intervention for in-stent restenosis of the saphenous vein graft using a non-contrast flush medium

      Zero contrast optical coherence tomography–guided percutaneous coronary intervention for in-stent restenosis of the saphenous vein graft using a non-contrast flush medium

      Percutaneous coronary intervention (PCI) is often denied for individuals with coronary artery disease who are prone to develop contrast-induced acute kidney injury . We report a 73-year-old, stage 3 chronic kidney disease patient (CKD), who underwent coronary artery bypass surgery and saphenous vein graft (SVG) stenting in the past, presented with in-stent restenosis (ISR) of SVG stent. Zero contrast optical coherence tomography (OCT) guided–PCI was successfully performed using low molecular weight dextran-40 (LMWD-40) as the flush medium. Our report suggests the safety and feasibility of LMWD-40–based OCT-guided zero contrast PCI in ISR of SVG in a CKD patient, although ...

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    49-72 of 3909 « 1 2 3 4 5 6 ... 161 162 163 »
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