1. Articles in category: Cardiology

    481-504 of 2527 « 1 2 ... 18 19 20 21 22 23 24 ... 104 105 106 »
    1. Optical coherence tomography guided primary PCI in STEMI patients. A pilot study

      Optical coherence tomography guided primary PCI in STEMI patients. A pilot study

      Background The objective of our study was to assess whether optical coherence tomography (OCT) guidance could guide intervention in order to avoid balloon angioplasty and stenting during primary PCI. Method One hundred patients with ST-segment elevation myocardial infarction (STEMI) and thrombus containing lesion were enrolled in this study. Thrombus-aspiration was performed in all cases followed by OCT study. Following thrombectomy, no stent was implanted in residual significant stenosis (>50%) if OCT suggested that the occlusion was mostly thrombotic, provided that patient were symptom-free and the TIMI flow was ≥2. All patients managed only by thrombectomy underwent one week and 9- ...

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    2. First Optical Coherence Tomography Imaging of Takayasu Coronary Arteritis

      First Optical Coherence Tomography Imaging of Takayasu Coronary Arteritis

      Coronary angiogram (cranial right view) showing a long severe stenosis (arrow) of the mid-portion of the LAD and FD– OCT showing a homogenous concentric stenosis, with high tissue backscatter, without any major lipid plaque (C7 Dragonfly FD-OCT catheter, St Jude Medical): longitudinal axis view (center panel) , cross sectional images (A to E) .

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      Mentions: St. Jude Medical
    3. Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography

      Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography

      Although previous optical coherence tomography (OCT) studies reported that restenosis tissue after implantation of a drug-eluting stent (DES) was composed of a variety of cells, the clinical significance of morphologic characteristics for in-stent neointimal tissue as assessed by OCT has not been clarified. We experienced a patient with stable angina who underwent percutaneous coronary intervention with a 2.5 × 18-mm DES implantation 6 months before the OCT examination. OCT imaging showed a mild intimal hyperplasia (39 % neointimal hyperplasia) with eccentric, heterogeneous tissue, predominantly of low signal intensity. Seventeen months after the initial procedure, OCT revealed a significant increase in percent ...

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    4. Method Of Processing Optical Coherence Tomography Images

      Method Of Processing Optical Coherence Tomography Images

      An automatic or semiautomatic method of processing intravascular Optical Coherence Tomography (OCT) images, comprising: pre-processing the primary image by segmenting the guidewire in the lumen to exclude it from the image, determining whether the lumen is open or closed; if the lumen is determined to be closed, performing a first automatic lumen segmentation procedure on the pre-processed image to define a perimeter line of the lumen, corresponding to the inner edge of the vessel wall, and determine a centroid CL of the lumen area; if the lumen is determined not to be closed, sequentially performing an automatic lumen closing procedure ...

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    5. Beware women who do binge drinking

      Beware women who do binge drinking

      Women who do binge drinking face a risk of birth defects known as fetal alcohol syndrome (FAS) that leads to growth retardation, head and face abnormalities and neurological problems. Till date, it was believed that FAS also caused heart problems in just over half of those with this condition but remained largely a mystery how. To unlock this mystery, a team led by an Indian-American researcher Ganga Karunamuni at Case Western University in Cleveland, Ohio, studied heart formation in quail embryos, whose heart development is very similar to that of humans. The team used optical coherence tomography - an innovative imaging ...

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    6. Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters

      Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters

      Objectives The main objective of this study is to determine the correlation between fractional flow reserve (FFR)- and frequency domain optical coherence tomography (FD-OCT)-measured lumen parameters, and to determine the diagnostic competence of FD-OCT concerning the identification of severe coronary stenosis. Methods A total of 41 coronary stenoses in 30 patients were assessed consecutively by quantitative coronary angiography (QCA), FFR, and FD-OCT. Stenoses were labeled severe if FFR ≤ 0.80. The minimal lumen area (MLA), minimal lumen diameter (MLD), and percent lumen area stenosis (%AS) were measured using FD-OCT. Results FFR was ≤0.80 in 10 stenoses (24.4 ...

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    7. Frequency-domain optical coherence tomography evaluation of a patient with Kawasaki disease and severely calcified plaque

      Frequency-domain optical coherence tomography evaluation of a patient with Kawasaki disease and severely calcified plaque

      Patients with Kawasaki disease (KD) not treated with immunoglobulin therapy have a 25% risk of developing coronary aneurysms, which lead to adverse cardiovascular events such as myocardial infarction and death . In addition, these individuals frequently present significant calcium deposits in regions of previous inflammation in the coronaries . OCT assessment of stent-vessel interactions seems to be more accurate than IVUS' in patients with highly calcified plaques .

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    8. Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses

      Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses

      Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real world, a variety of definitions are being used by different groups and by different core laboratories to analyze OCT findings because of different clinical/procedural contexts in which OCT research has been carried out. This comprehensive overview is aimed to summarize different applicable definitions used by different research groups in plaque and stent analysis using OCT. In addition ...

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    9. Optical Coherence Tomography of a Bifurcation Lesion Treated With Bioresorbable Vascular Scaffolds With the “Mini-Crush” Technique

      Optical Coherence Tomography of a Bifurcation Lesion Treated With Bioresorbable Vascular Scaffolds With the “Mini-Crush” Technique

      A 51-year-old man was referred for coronary angiography following a positive scintigraphy test for anterior and anterolateral ischemia. Angiography showed a chronic total occlusion of the mid-left anterior descending coronary artery (LAD) and stenosis of the ostial first diagonal branch (Figure 1 ). The total occlusion of the LAD was crossed, and rotablation was performed. A 2.5 × 28-mm Absorb bioresorbable vascular scaffold (BVS) stent (Abbott Vascular, Santa Clara, California) was implanted in the LAD just distal to the first diagonal. A second 2.5 × 18-mm Absorb was implanted in the first diagonal branch. Optical coherence tomography (OCT) imaging demonstrated that ...

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    10. Frequency-Domain Optical Coherence Tomography Assessment of Unfavorable Kissing-Balloon Result in Unprotected Left Main Intervention

      Frequency-Domain Optical Coherence Tomography Assessment of Unfavorable Kissing-Balloon Result in Unprotected Left Main Intervention

      A 67-year-old man with a history of hypertension and dyslipidemia was admitted because of angina symptoms. Coronary angiography (CAG) showed an eccentric lesion of the distal unprotected left main coronary artery (ULMCA) involving the ostium of the left anterior descending coronary artery (LAD) (Figure 1 A). ULMCA/LAD crossover stent implantation was conducted with a 3.5 × 18-mm everolimus-eluting stent (EES) (XIENCE PRIME, Abbott Vascular, Santa Clara, California) at 12 atm, followed by the kissing-balloon technique (KBT). Despite a favorable CAG result (Figure 2 A), frequency-domain optical coherence tomography (FD-OCT) revealed stent strut deformation towards the LAD, leading to a ...

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    11. High frame-rate intravascular optical frequency-domain imaging in vivo

      High frame-rate intravascular optical frequency-domain imaging in vivo

      Intravascular optical frequency-domain imaging (OFDI), a second-generation optical coherence tomography (OCT) technology, enables imaging of the three-dimensional (3D) microstructure of the vessel wall following a short and nonocclusive clear liquid flush. Although 3D vascular visualization provides a greater appreciation of the vessel wall and intraluminal structures, a longitudinal imaging pitch that is several times bigger than the optical imaging resolution of the system has limited true high-resolution 3D imaging, mainly due to the slow scanning speed of previous imaging catheters. Here, we demonstrate high frame-rate intravascular OFDI in vivo, acquiring images at a rate of 350 frames per second. A ...

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    12. Calibration of intravascular optical coherence tomography as presented in peer reviewed publications

      Calibration of intravascular optical coherence tomography as presented in peer reviewed publications

      Intravascular optical coherence tomography (OCT) is a new imaging modality in interventional cardiology providing high-resolution intracoronary images. The modality is already established as an efficient and precise research tool and is increasingly used for guiding coronary intervention. The quantitative capabilities of marketed OCT systems have been validated and measurements are found accurate and precise in bench testing .

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    13. Avinger Completes Major New Financing

      Avinger Completes Major New Financing

      Successful financial transaction will support continued commercial growth of lumivascular platform and enrollment of the VISION trial, the US pivotal study demonstrating safety and effectiveness of Pantheris TM , the first ever image-guided atherectomy technology Avinger, Inc. producer of therapeutic devices incorporating intravascular imaging and pioneer of the lumivascular approach to treating vascular disease, announced today the closing of a significant funding round. Both new as well as existing investors participated in the financing. "We are very pleased with the outcome of this recent capital raise, to support what we anticipate to be a very successful clinical trial of Pantheris, the ...

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    14. Final Results of the Chronic Total Occlusion Crossing With the Ocelot System II (CONNECT II) Study

      Final Results of the Chronic Total Occlusion Crossing With the Ocelot System II (CONNECT II) Study

      Purpose : To evaluate the safety and effectiveness of the optical coherence tomography-guided Ocelot catheter to cross femoropopliteal chronic total occlusions (CTOs). Methods : The CONNECT II study was a prospective, multicenter, non-randomized single-arm study of the safety and effectiveness of the Ocelot catheter in CTO crossing. Key inclusion criteria were a 99% to 100% stenosed femoropopliteal segment, lesion length between 1 and 30 cm, and resistance to guidewire crossing. The main exclusion criterion was a severely calcified target vessel. The primary safety endpoint was 30-day major adverse events (MAE), while the primary effectiveness endpoint was successful CTO crossing (i.e., guidewire ...

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    15. Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent and Platelet AggregatioN Studies In Patients With Stable Angina Managed as Elective Case

      Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent and Platelet AggregatioN Studies In Patients With Stable Angina Managed as Elective Case

      To treat patients with stable coronary artery disease, elective percutaneous coronary intervention (PCI) will be performed with the use of an everolimus-eluting cobalt- chromium stent (everolimus-eluting stent: EES, Xience Prime, Xpedition), which is the current standard drug-eluting stent (DES). Vascular responses at the site of stent placement will be evaluated by optical coherence tomography (OCT) at 1 or 3 months and at 12 months after stent placement, along with observation of changes over time in the target vessel. The relationships between OCT findings and the time course of platelet aggregation and between OCT findings and the occurrence of major cardio- ...

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    16. Multicenter Randomized Comparison of Early Vascular Responses Between Multicenter Randomized Comparison of Early Vascular Responses Between Everolimus-eluting Cobalt-CHromium Stent ANd Identically DeSigned Bare-Metal Stent in Patients With Acute Myocardia

      Multicenter Randomized Comparison of Early Vascular Responses Between Multicenter Randomized Comparison of Early Vascular Responses Between Everolimus-eluting Cobalt-CHromium Stent ANd Identically DeSigned Bare-Metal Stent in Patients With Acute Myocardia

      To evaluate early vessel response between current standard drug-eluting stent and bare-metal stent in acute myocardial infarction (AMI) patients by optical coherence tomography (OCT).

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    17. Massachusetts General Hospital Receives NIH Grant for Studying the Natural History of Vulnerable Coronary Plaques

      Massachusetts General Hospital Receives NIH Grant for Studying the Natural History of Vulnerable Coronary Plaques

      Massachusetts General Hospital Received a 2013 NIH Grant for $720,595 for Studying the Natural History of Vulnerable Coronary Plaques. The principal Investigator is Guillermo Tearney. The program began in 2004 and ends in 2015. Below is summary of the proposed work. The importance of coronary atherosclerosis and its clinical manifestations cannot be overstated; in this country, half a million people die from acute myocardial infarction every year and an equal number of patients survive with substantial morbidity. Coronary atherosclerosis is an inflammatory process governed by dysregulated endothelium, leukocytes, macrophages, and smooth muscle cells. These cells conspire to form lesions ...

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    18. Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging

      Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging

      Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in the tissue, which is required for a more complete understanding and accurate diagnosis of coronary disease. Here we present a dual-modality imaging system and catheter that uniquely combines IVOCT with diffuse near-infrared spectroscopy (NIRS) in a single dual-modality imaging device for simultaneous acquisition of microstructural and compositional information. As a proof-of-concept demonstration, the device has been used to visualize co-incident microstructural and spectroscopic information obtained from a diseased cadaver ...

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    19. Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques (Textbook)

      Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques (Textbook)

      The first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise—with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists—especially neuroradiologists—how to optimize the use of the many techniques available in order ...

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    20. Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms

      Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms

      Optical coherence tomography images of human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall. These disorders can be employed as indicators for wall degradation and, therefore, become a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. Two approaches are followed to evaluate this risk: the analysis of the reflectivity decay along the penetration depth and the textural analysis of a two-dimensional spatial distribution of the aortic wall backscattering. Both techniques require preprocessing stages for the identification of the air–sample interface and for the segmentation ...

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    21. Mid-Ventricular Tako-Tsubo Cardiomyopathy With Structurally Normal Coronary Arteries Confirmed by Optical Coherence Tomography

      Mid-Ventricular Tako-Tsubo Cardiomyopathy With Structurally Normal Coronary Arteries Confirmed by Optical Coherence Tomography

      Tako-Tsubo cardiomyopathy is an entity of unknown etiology characterized by transient apical dyskinesia in patients with angiographically normal coronary arteries. However, atypical forms of Tako-Tsubo cardiomyopathy may also occur, affecting other myocardial segments. Optical coherence tomography has a unique resolution and may detect angiographically silent atherosclerotic coronary artery disease. In this report, we describe optical coherence tomography findings in a patient with atypical Tako-Tsubo cardiomyopathy presenting as transient mid-ventricular ballooning.

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      Mentions: Fernando Alfonso
    22. Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

      Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

      During the pathogenesis of coronary atherosclerosis, from lesion initiation to rupture, arterial mechanical properties are altered by a number of cellular, molecular, and hemodynamic processes. There is growing recognition that mechanical factors may actively drive vascular cell signaling and regulate atherosclerosis disease progression. In advanced plaques, the mechanical properties of the atheroma influence stress distributions in the fibrous cap and mediate plaque rupture resulting in acute coronary events. This review paper explores current optical technologies that provide information on the mechanical properties of arterial tissue to advance our understanding of the mechanical factors involved in atherosclerosis development leading to plaque ...

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    23. A coronary "tunnel": Optical coherence tomography assessment after rotational atherectomy

      A coronary "tunnel": Optical coherence tomography assessment after rotational atherectomy

      A 81-year-old woman was admitted for exertional angina. Coronary angiogram revealed a severely calcific proximal circumflex lesion. Rotational atherectomy was performed with 1.5 and 1.75 burrs, obtaining a good angiographic result. Optical coherence tomography (OCT) assessment revealed a large dissection parallel to the true lumen. We implanted a 3.0 mm × 38 mm Xience Prime ® stent and postdilated it with a 3.0-mm non-compliant balloon. Final OCT pullback showed mild malapposed struts with large lumen area. 3D-OCT reconstruction confirmed a large lumen after stent implantation.

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