1. Articles in category: Cardiology

    481-504 of 3047 « 1 2 ... 18 19 20 21 22 23 24 ... 125 126 127 »
    1. Avinger Announces 30-Day VISION Trial Results At EuroPCR 2015

      Avinger Announces 30-Day VISION Trial Results At EuroPCR 2015

      Avinger, Inc., (Nasdaq:AVGR) a developer and manufacturer of image-guided, catheter-based systems for the treatment of peripheral arterial disease (PAD) and pioneer of the lumivascular approach to treating vascular disease, today announced 30-day interim results for its VISION clinical study. VISION is designed to evaluate the safety and efficacy of the Pantheris™ system to perform directional atherectomy, while for the first time ever allowing physicians to use real-time intravascular imaging to aid in the removal of plaque from diseased lower extremity arteries. Results were presented by Arne Schwindt, M.D. of St. Franziskus Hospital in Muenster, Germany at the EuroPCR ...

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    2. New Journal Article Highlights Mechanical Effects of Orbital Atherectomy and Rotational Atherectomy in Treating Heavily Calcified Coronary Lesions

      New Journal Article Highlights Mechanical Effects of Orbital Atherectomy and Rotational Atherectomy in Treating Heavily Calcified Coronary Lesions

      Cardiovascular Systems, Inc. (CSI) (NASDAQ: CSII) today announced that a new article e-published in May 2015 in The Journal of Catheterization and Cardiovascular Intervention highlights the mechanical effect of orbital atherectomy (OA) and rotational atherectomy (RA) in treating heavily calcified coronary lesions. ” The article, titled “Optical Coherence Tomography Assessment of the Mechanistic Effects of Rotational and Orbital Atherectomy in Severely Calcified Coronary Lesions,” details results from a study led by Dr. Annapoorna Kini, Professor of Cardiology at the Mount Sinai Hospital and Icahn School of Medicine, and Director of The Cardiac Catheterization Lab at Mount Sinai Hospital. Said study co-investigator ...

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    3. Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Aims: Newly developed drug-eluting stents (DES) aim to promote early endothelialisation and prevent stent thrombosis. We sought to evaluate the extent of neointima growth by optical coherence tomography (OCT) three months after implantation of a polymer-free stent with a nano-sized-pore surface eluting sirolimus. Methods and results: In this prospective, multicentre, open-label study, patients were enrolled with documented stable angina or silent ischaemia and planned intervention for up to two de novo coronary lesions (in different vessels), with lesion length of ≤18 mm. The primary OCT endpoint was the percentage of in-stent neointimal volume obstruction at three months. The secondary endpoints ...

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    4. Use of Intracoronary imaging in ST Elevation Myocardial Infarction with coronary artery aneurysm and very late stent thrombosis

      Use of Intracoronary imaging in ST Elevation Myocardial Infarction with coronary artery aneurysm and very late stent thrombosis

      The use of Optical Coherence Tomography (OCT)-guided percutaneous coronary intervention (PCI) has been described in ST-Elevation Myocardial Infarction (STEMI) involving relatively simple culprit lesions [1]. Coronary artery aneurysms have a reported incidence of up to 4.9% among coronary angiograms performed and may present clinically as STEMI either from thrombus formation or embolic phenomena [2]. There has been limited experience described regarding the use of OCT in STEMI with an aneurysm in the infarct related artery (IRA).

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    5. Erasmus MC plans to appoint a PhD candidate in the field Intravascular Optical Coherence Tomography (Heartbeat OCT)

      Erasmus MC plans to appoint a PhD candidate in the field Intravascular Optical Coherence Tomography (Heartbeat OCT)

      Job description In the project Heartbeat OCT we will realize a superfast optical imaging system for use in the coronary arteries, the blood vessels around the heart. Patients who get treated after e.g. a heart attack often benefit from intravascular imaging to guide the treatment. Since the heart is a moving organ, slow imaging can cause motion blur, making the imaging less precise. If the imaging is fast enough, it is possible to image an entire artery in the short time between two heart beats, when the heart does not move. In the present project, we will develop the ...

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    6. Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions

      Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions

      Introduction Accuracy of intracoronary imaging to discriminate functionally significant coronary stenosis according to vessel diameter remains to be defined. Methods PubMed, Scopus, and Google Scholar were systematically searched for studies assessing diagnostic accuracy (area under the receiver operating characteristic curve [AUC], the primary end point) and sensitivity and specificity (the secondary end points) of minimal luminal area (MLA) or of minimal luminal diameter (MLD) derived from intravascular ultrasound (IVUS) or optical coherence tomography (OCT) to detect functionally significant stenosis as determined with fractional flow reserve (FFR). Results Fifteen studies were included, 2 with 110 patients analyzing only left main (LM ...

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    7. Optical coherence tomography assessment of the mechanistic effects of rotational and orbital atherectomy in severely calcified coronary lesions

      Optical coherence tomography assessment of the mechanistic effects of rotational and orbital atherectomy in severely calcified coronary lesions

      Objectives This study sought to assess the mechanistic effect of rotational atherectomy (RA) and orbital atherectomy (OA) on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background RA and OA are two main approaches to ablate coronary calcium. While small case reports have described the mechanistic effect of RA in calcified coronary lesions, there has been no imaging study to assess the effect of OA on coronary artery architecture and/or compare the effects of two atherectomy devices. Methods This study analyzed 20 consecutive patients with OCT imaging performed after atherectomy and after stent implantation ...

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    8. Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Received a 2015 NIH Grant for $780,355 for Intracoronary Imaging of Plaque Collagen in Patients. The principal investigator is Seemantini Nadkarni. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The goal of this proposal is to develop and validate an intracoronary imaging device for the assessment of plaque collagen content and architecture in patients. Acute myocardial infarction (AMI), caused by the rupture of unstable plaque, is the leading cause of death worldwide. Collagen and vascular smooth muscle cells (vSMCs) together impart mechanical stability to a plaque, and ...

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    9. Tiny Camera Sees Inside Blood Vessels

      Tiny Camera Sees Inside Blood Vessels

      Ahead of any surgical procedure, doctors try to learn as much as possible about the state of the organs they plan to operate on. A new camera developed in the Netherlands can now make that easier - giving surgeons an incredibly detailed look inside blood vessels, all the way to the patient’s heart. Blockages in coronary arteries, caused by the buildup of plaque, are the main cause of heart attacks. In most cases, doctors treat the problem by widening the artery with a mechanical device called a stent, inserted at the end of a long thin wire-like catheter. But within ...

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    10. University of Maryland Receives NIH Grant for Identification of AF Ablation Targets via a Steerable Actuated Catheter

      University of Maryland Receives NIH Grant for Identification of AF Ablation Targets via a Steerable Actuated Catheter

      University of Maryland Receives a 2015 NIH Grant for $222,800 for Identification of AF Ablation Targets via a Steerable Actuated Catheter. The principal investigator is Jaydev Desai. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. Atrial fibrillation (AF) is the most common cardiac arrhythmia and has high patient morbidity, increases mortality two-fold, and increases health care costs. Each year, about 200,000 Americans are newly diagnosed with AF with a prevalence of several million in the U.S. alone. In the majority of cases, AF has been shown to originate ...

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    11. University of California Irvine Receives NIH Grant for Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California Irvine Receives NIH Grant for Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California Irvine Receives a 2015 NIH Grant for $664,990 for Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging. The principal investigator is Zhongping Chan The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution of ...

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    12. Spontaneous healing of spontaneous coronary artery dissection after balloon angioplasty: Follow-up for over 9months using optical coherence tomography and intravascular ultrasound

      Spontaneous healing of spontaneous coronary artery dissection after balloon angioplasty: Follow-up for over 9months using optical coherence tomography and intravascular ultrasound

      A 36-year-old, 1-week postpartum woman who delivered a second male baby presented to our hospital with sudden-onset substernal chest pain. She previously had pregnancy-induced hypertension and smoked between the ages of 20 and 27 years. She had no personal medical history or family history of coronary artery disease. Electrocardiography showed normal sinus rhythm with ST elevation in the precordial leads, and transthoracic echocardiography depicted anterior wall akinesis, suggesting anterior acute myocardial infarction.

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    13. Drug-coated balloon without stent implantation for chronic total occlusion of coronary arteries: description of a new strategy with an optical coherence tomography responce

      Drug-coated balloon without stent implantation for chronic total occlusion of coronary arteries: description of a new strategy with an optical coherence tomography responce

      Chronic total occlusion (CTO) revascularization of coronary arteries is often a complex intervention whose success is lower than other percutaneous interventions. The reason for this uncertainty is related to the more complex anatomical setting and the increased risk of complications [1]. Moreover, this intervention is burdened by higher use of X-rays, contrast media and higher costs. On top of these informations, the most recent scientific data show how an effective CTO revascularization improves the prognosis reducing the risk of cardiac mortality and major adverse cardiovascular events (MACE) if compared to medical therapy [2,3].

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    14. Correlation Between OCT-Derived Intrastent Dimensions and Fractional Flow Reserve Measurements After Coronary Stent Implantation and Impact on Clinical Outcome

      Correlation Between OCT-Derived Intrastent Dimensions and Fractional Flow Reserve Measurements After Coronary Stent Implantation and Impact on Clinical Outcome

      Background. Insufficient stent expansion, vessel wall injury, and tissue prolapse, all frequently unrecognized by coronary angiography, are predictors of future major adverse cardiac event (MACE) after percutaneous coronary intervention (PCI). Optical coherence tomography (OCT) provides accurate visualization of these features of inadequate stent deployment, whereas reduced fractional flow reserve (FFR) values after PCI indicate functional significance of a residual intrastent stenosis. Objective. To investigate the relationship of OCT-derived intrastent lumen dimensions and FFR-derived hemodynamic relevance immediately after coronary stent implantation and to evaluate the clinical impact of these parameters at follow-up. Methods. In 66 stable patients with a coronary de ...

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    15. Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography

      Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography

      Aims To investigate the impact of lesion angle on the incidence and distribution of acute vessel wall injuries and incomplete stent apposition (ISA) following second-generation drug-eluting stent (DES) implantation using optical coherence tomography (OCT). Several ex vivo studies demonstrated that angled arterial walls are exposed to imbalanced mechanical stress from deployed stents. Methods and results We included 243 lesions treated with a single DES (148 everolimus-eluting stent and 95 zotarolimus-eluting stent). Angled lesions were defined as lesions with angle ≥45° on an angiogram ( n = 58). The vessel wall injuries and ISA were evaluated by OCT. The results were compared with ...

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    16. Optical coherence tomography can visualize the pulmonary artery in Williams-Beuren syndrome

      Optical coherence tomography can visualize the pulmonary artery in Williams-Beuren syndrome

      Williams–Beuren syndrome (WBS) is caused by a microdeletion at the 7q11.23, including the ELN gene. In the absence of elastin, pervasive subendothelial migration and proliferation of smooth muscle cells cause occlusion of the vascular lumen. We assessed peripheral pathological findings of the pulmonary artery (PA) in …

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    17. Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis: Single-Center Experience

      Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis: Single-Center Experience

      Background— As bioresorbable vascular scaffolds (BVSs) are being increasingly used in complex real-world lesions and populations, BVS thrombosis cases have been reported. We present angiographic and optical coherence tomography (OCT) findings in a series of patients treated in our center for definite bioresorbable scaffold thrombosis. Methods and Results— Up to June 2014, 14 patients presented with definite BVS thrombosis in our center. OCT was performed in 9 patients at the operator’s discretion. Angiographic and OCT findings were compared with a control group comprising 15 patients with definite metallic stent thrombosis. In the BVS group, time interval from index procedure ...

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    18. Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study

      Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study

      Intracoronary optical frequency domain imaging (OFDI), requires the displacement of blood for clear visualization of the artery wall. Radiographic contrast agents are highly effective at displacing blood however, may increase the risk of contrast-induced nephropathy. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. The aim of this work was to determine the optimal flushing parameters necessary to reliably perform intracoronary OFDI while reducing the volume of administered radiographic contrast, and assess the influence of flushing media choice on vessel wall measurements. 144 OFDI pullbacks were acquired together ...

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    19. Association of wall shear stress with long-term vascular healing response following bioresorbable vascular scaffold implantation

      Association of wall shear stress with long-term vascular healing response following bioresorbable vascular scaffold implantation

      Bioresorbable vascular scaffolds (BVS) could potentially overcome pitfalls of metal stents, such as late failure and neoatherosclerosis [1]. At the long-term follow-up of the everolimus-eluting BVS (Absorb BVS 1.0; Abbott Vascular, Santa Clara, CA), complete strut bioresorption accompanied by late luminal enlargement and development of a signal-rich layer covering underlying thrombogenic plaque components were observed by optical coherence tomography (OCT) 5 years after implantation [1,2]. The vascular architecture after bioresorption resembled a native non-obstructive atherosclerotic plaque with varying morphology among subjects [1].

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    20. Successful Stenting With Optical Frequency Domain Imaging Guidance For Spontaneous Coronary Artery Dissection

      Successful Stenting With Optical Frequency Domain Imaging Guidance For Spontaneous Coronary Artery Dissection

      A 51-year-old woman was urgently admitted because of chest pain. Emergent coronary angiography revealed diffuse stenosis from the proximal to distal portion of the right coronary artery (RCA) with Thrombolysis In Myocardial Infarction (TIMI) flow grade 2 (Figure 1 ). No stenosis was seen in the left coronary artery. Intravascular ultrasound (IVUS) images revealed an intracoronary hematoma from the posterior descending artery (PDA) to the ostium of the RCA, but could not demonstrate the entry point of the hematoma (Figure 1 ). Optical frequency domain imaging (OFDI; Terumo, Tokyo, Japan) images clearly demonstrated, not only intracoronary hematoma from the PDA to the ...

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    21. IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY

      IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY

      Optical coherence tomography (OCT) is a relatively new imaging modality similar with ultrasound where the sound waves are replaced by ballistic photons. OCT provides images at high spatial resolution which allow for the identification of micron size morphological tissue structures. A high impact application is visualization of arterial wall and atherosclerotic plaques. Despite high spatial resolution to complete the transfer of this imaging modality into clinical environment there is a need for markers which would quantify the physiological condition of the sample. Finding the proper markers is a topic of high interest for many research groups. A potential marker suggested ...

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    22. Detection of Atherosclerotic Plaque from Optical Coherence Tomography Images Using Texture-Based Segmentation

      Detection of Atherosclerotic Plaque from Optical Coherence Tomography Images Using Texture-Based Segmentation

      Detection of atherosclerotic plaque from optical coherence tomography (OCT) images by visual inspection is difficult. We developed a texture based segmentation method to identify atherosclerotic plaque automatically from OCT images without any reliance on visual inspection. Our method involves extraction of texture statistical features (spatial gray level dependence matrix method), application of an unsupervised clustering algorithm (K-means) on these features, and mapping of the clustered regions: background, plaque, vascular tissue and an OCT degraded signal region in feature-space, back to the actual image. We verified the validity of our results by visual comparison to photographs of the vascular tissue with ...

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    23. Intra- and Inter-Frame Differential Doppler Optical Coherence Tomography

      Intra- and Inter-Frame Differential Doppler Optical Coherence Tomography

      Spectrometer based optical coherence tomography suffers from fringe washout for fast flow, a drawback for flow visualization, which is of interest for both lable-free optical angiography and flow quantification. We presented a method, which can be used to contrast very fast flows, while maintaining relatively low A-scan rates. It is based on introducing a phase shift of during acquisition such that the interference fringes associated to moving sample structures are recovered depending on the axial velocity. This enables the use of slower line scan cameras for measuring the fast blood flows within the large vessels in the region of the ...

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