1. Articles in category: Cardiology

    481-504 of 2159 « 1 2 ... 18 19 20 21 22 23 24 ... 88 89 90 »
    1. Combined use of optical coherence tomography and intravascular ultrasound imaging for the evaluation of stent thrombosis

      Combined use of optical coherence tomography and intravascular ultrasound imaging for the evaluation of stent thrombosis

      Stent thrombosis (ST) represents the most feared complication after the percutaneous treatment of a coronary stenosis, usually involving very serious or fatal consequences for the patient. The interest in ST was initiated after the first longitudinal follow-up of drug-eluting stents (DES), which dramatically decrease the rate of restenosis. Further investigation revealed that ST is not a class effect, also affecting bare metal stents, and that several factors are potentially implicated in the physiopathology of ST [1]. While subacute thrombosis seem to be more related to mechanical problems during deployment, late and very late ST described in DES have been associated ...

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    2. Qualitative and Quantitative Assessment of Stent Restenosis by Optical Coherence Tomography

      Qualitative and Quantitative Assessment of Stent Restenosis by Optical Coherence Tomography

      We hypothesized that the tissue components of in-stent restenosis (ISR) might differ between drug-eluting stents (DES) and bare-metal stents (BMS) and that these differences could be distinguished by qualitative and quantitative optical coherence tomography (OCT) analyses. Methods and Results:  One-hundred and twenty-two initial ISR lesions (sirolimus-eluting stents: n=28; paclitaxel-eluting stents: n=51; BMS: n=43) were evaluated with OCT. Based on their OCT appearance, the lesions were classified as homogeneous, layered or heterogeneous. The optical properties of backscatter, attenuation and signal intensity of the neointimal tissue (NIT) were quantified. To evaluate the vascular response after balloon angioplasty (BA), the ...

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    3. Displaying Corporate Financial Strength and Confidence in The Future, St. Jude Medical Authorizes $1B Share Repurchase.

      Displaying Corporate Financial Strength and Confidence in The Future, St. Jude Medical Authorizes $1B Share Repurchase.

      St. Jude Medical’s Board of Directors recently authorized a share repurchase of up to $1B of its outstanding common stock.(see article ) This can be see as an impressive statement on St. Jude Medical’s financial strength and a strong belief in the long term opportunities for the company and a response due to a sudden stock drop (see article ). It seems this, combined with many other corporate activities, has had a positive effect on the company’s stock. St. Jude also recently announced the start of a new study to investigate how OCT, IVUS, and FFR can be ...

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    4. Erosion/malapposition of a sirolimus eluting stent – Optical coherence tomography image – A case report

      Erosion/malapposition of a sirolimus eluting stent – Optical coherence tomography image – A case report

      The presence of erosion/malapposition of a Sirolimus eluting stent was clearly visualized using Optical Coherence Tomography (OCT) imaging. The presence of erosion/malapposition and the absence of neointimal hyperplasia after 10 months of sirolimus eluting stent could constitute a potential thrombogenic substrate for late stent thrombosis.

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      Mentions: St. Jude Medical
    5. Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Aims: The main cause of acute myocardial infarction (AMI) is the disruption of a thin-cap fibroatheroma (TCFA) and subsequent thrombosis. Mortality increases in diabetic patients due to cardiovascular events; there may be differences in the vulnerable plaques between diabetic and non-diabetic patients. We used optical coherence tomography (OCT) to assess the incidence of vulnerable plaques in diabetic patients with AMI. Methods and results: OCT was performed in all three major coronary arteries of 70 AMI patients: 48 non-diabetic and 22 diabetic patients. The OCT criterion for TCFA was the presence of both a lipid-rich plaque composition and a fibrotic cap ...

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    6. The diabetes conundrum: despite increasing incidences of coronary disease in diabetic type II patients, their first cathlab presentation is later than expected. Observations from an angiographic and optical coherence tomography study

      The diabetes conundrum: despite increasing incidences of coronary disease in diabetic type II patients, their first cathlab presentation is later than expected.  Observations from an angiographic and optical coherence tomography study

      Niccoli et al . assessed the severity of coronary artery disease (CAD) in the culprit vessels of diabetic type II as well as non-diabetic patients ( n = 167) at the time of their first coronary event employing standard coronary angiography and intracoronary optical coherence tomography (OCT) imaging ( n = 72). 1 To assess the severity of CAD, they applied the Bogarty, Gensini, and Sullivan scores, and to evaluate the development of collaterals they used the Rentrop score, all based on coronary angiography. Intracoronary imaging by OCT was performed to study coronary plaque morphology, more particularly to quantify the amount of lipids and calcification ...

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    7. Multimodality Imaging of a Rare Complex Vascular Ring in an Infant: Left Pulmonary Sling Associated With Aorto-Pulmonary Window, Aberrant Right Subclavian Artery, and With Complete Tracheal Rings

      Multimodality Imaging of a Rare Complex Vascular Ring in an Infant: Left Pulmonary Sling Associated With Aorto-Pulmonary Window, Aberrant Right Subclavian Artery, and With Complete Tracheal Rings

      A 6-week-old female was referred to our unit because of increasing respiratory distress. The echocardiography (A and B, Online Videos 1 and 2) showed a large aorto-pulmonary window (APW, arrow in A) with a broad communication between the aorta (AO) and pulmonary artery (PA), anomalous origin of left pulmonary artery (LPA) from the right pulmonary artery with retrotracheal course (asterisk in B), and aberrant right subclavian artery. Computed tomography (C and D), bronchography (F), and flexible bronchoscopy (G) were used to confirm the diagnosis and further demonstrated tracheal compression. The origin of the right upper lobe bronchus (F, red arrow ...

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    8. Avinger Receives FDA Clearance for Ocelot | PIXL

      Avinger Receives FDA Clearance for Ocelot | PIXL

      Avinger Press Release - Avinger Inc., a medical device manufacturer of innovative, multi-functional imaging catheters for crossing chronic total occlusions (CTOs) in patients with Peripheral Artery Disease (PAD), has received FDA clearance to market Ocelot | PIXL in the United States. Just one month after receiving clearance to commercially sell the Ocelot System in the US, the first-ever CTO crossing device with onboard imaging, Avinger debuts its newest member of the Ocelot family. “With its smaller profile and longer length, Ocelot | PIXL is designed to bring all the benefits of Ocelot to help physicians treat more patients with smaller arteries” “With its ...

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    9. Fully automatic three-dimensional visualization of intravascular optical coherence tomography images: methods and feasibility in vivo

      Fully automatic three-dimensional visualization of intravascular optical coherence tomography images: methods and feasibility in vivo

      Intravascular optical coherence tomography (IV-OCT) is an imaging modality that can be used for the assessment of intracoronary stents. Recent publications pointed to the fact that 3D visualizations have potential advantages compared to conventional 2D representations. However, 3D imaging still requires a time consuming manual procedure not suitable for on-line application during coronary interventions. We propose an algorithm for a rapid and fully automatic 3D visualization of IV-OCT pullbacks. IV-OCT images are first processed for the segmentation of the different structures. This also allows for automatic pullback calibration. Then, according to the segmentation results, different structures are depicted with different ...

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    10. St. Jude Medical Enrolls First Patient in ILUMIEN I Study to Develop Guidance for Stent Optimization

      St. Jude Medical Enrolls First Patient in ILUMIEN I Study to Develop Guidance for Stent Optimization

      St. Jude Medical Press Release - St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the first patient enrollment in its ILUMIEN I clinical study. This observational study is designed to show the optimal way Optical Coherence Tomography (OCT), an intravascular imaging technology, combined with the St. Jude Medical PressureWire ™ Aeris , a wireless interventional tool that measures Fractional Flow Reserve (FFR), can guide stent implantation in patients with coronary artery disease. The study will observe and record how physicians treat patients while undergoing Percutaneous Coronary Intervention (PCI), and will also measure outcomes according to various procedural parameters ...

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    11. Intravascular optical technology to enable comprehensive in vivo coronary pathology

      Intravascular optical technology to enable comprehensive in vivo coronary pathology

      A single intracoronary optical device yields concurrent and combined microstructural and fluorescence information from luminal samples, such as arterial tissue. Cardiovascular disease is the leading cause of mortality in the United States (777,000 cases in 2010). 1 In a large percentage of patients, the first occurrence of coronary artery disease is either sudden death or acute myocardial infarction. Approximately 20–30% of the patients with acute myocardial infarction die before they get to a hospital. It is known that certain unstable atherosclerotic plaques, called vulnerable plaques, give rise to acute coronary events. Plaque stability is dependent on various factors ...

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    12. A randomized multicenter comparison of hybrid sirolimus-eluting stents with bioresorbable polymer versus everolimus-eluting stents with durable polymer in total coronary occlusion: rationale and design of the Primary Stenting of Occluded Native Coronary A

      A randomized multicenter comparison of hybrid sirolimus-eluting stents with bioresorbable polymer versus everolimus-eluting stents with durable polymer in total coronary occlusion: rationale and design of the Primary Stenting of Occluded Native Coronary A

      Background Percutaneous recanalization of total coronary occlusion (TCO) was historically hampered by high rates of restenosis and reocclusions. The PRISON II trial demonstrated a significant restenosis reduction in patients treated with sirolimus-eluting stents compared with bare metal stents for TCO. Similar reductions in restenosis were observed with the second-generation zotarolimus-eluting stent and everolimus-eluting stent. Despite favorable anti-restenotic efficacy, safety concerns evolved after identifying an increased rate of very late stent thrombosis (VLST) with drug-eluting stents (DES) for the treatment of TCO. Late malapposition caused by hypersensitivity reactions and chronic inflammation was suggested as a probable cause of these VLST. New ...

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      Mentions: Tom Adriaenssens
    13. Development and application of optical imaging techniques in diagnosing cardiovascular disease (Thesis)

      Development and application of optical imaging techniques in diagnosing cardiovascular disease (Thesis)

      Atherosclerosis and specifically rupture of vulnerable plaques account for 23% of all deaths worldwide, far surpassing both infectious diseases and cancer. Plaque-based macrophages, often associated with lipid deposits, contribute to atherogenesis from initiation through progression, plaque rupture and ultimately, thrombosis. Therefore, the macrophage is an important early cellular marker related to vulnerability of atherosclerotic plaques. The objective of my research is to assess the ability of multiple optical imaging modalities to detect, and further characterize the distribution of macrophages (having taken up plasmonic gold nanoparticles as a contrast agent) and lipid deposits in atherosclerotic plaques. Tissue phantoms and macrophage cell ...

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    14. DETErmination of the Duration of the Dual Antiplatelet Therapy by the Degree of the Coverage of The Struts on Optical Coherence Tomography From the Randomized Comparison Between Everolimus-eluting Stents Versus Biolimus A9-eluting Stents; DETECT-OCT Trial

      DETErmination of the Duration of the Dual Antiplatelet Therapy by the Degree of the Coverage of The Struts on Optical Coherence Tomography From the Randomized Comparison Between Everolimus-eluting Stents Versus Biolimus A9-eluting Stents; DETECT-OCT Trial

      The purpose of the study is 1> to compare neointimal stent coverage after OCT-guided vs. Angio-guided PCI, 2> to compare neointimal stent coverage at 3 months after EES (Xience Prime®) vs N-BES (Nobori®) implantation, and 3> to determine the duration of dual antiplatelet therapy by OCT measurement at 3 months.

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    15. Optical coherence tomography: from research to clinical application

      Optical coherence tomography: from research to clinical application

      Optical coherence tomography (OCT) has revolutionized intracoronary imaging. The unprecedented spatial resolution of this technique (15 μm) provides unique insights on the microstructure of the coronary wall. Currently, OCT is increasingly used in clinical practice and also constitutes an emerging, highly robust, research tool. OCT allows detailed visualization of atherosclerotic plaques and provides reliable information on plaque composition (lipid, fibrous, calcified) although its limited tissue penetration usually precludes a comprehensive analysis of the total plaque burden. OCT is the only technique allowing accurate measurements of the thickness of the fibrous cap, a classical marker of plaque vulnerability, and readily detects ...

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    16. Mercy leader in nation in using new technology

      Mercy leader in nation in using new technology

      Mercy Hospital, part of Allina Health, is among the first facilities in the U.S. to use the ILUMIEN™ PCI Optimization System from St. Jude Medical, the first and only integrated diagnostic technology that combines optical coherence tomography (OCT) and fractional flow reserve (FFR) technologies on one platform. Using the combined ILUMIEN system, physicians at Mercy Hospital gain advanced physiological and anatomical insights that can improve the diagnosis and treatment of coronary artery disease. Dr. Jeffrey Chambers, director of the cardiac catheterization lab at the Metropolitan Heart & Vascular Institute, first used the system on a coronary artery patient soon after ...

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    17. Massachusetts General Hospital received a 2012 NIH Grant for studying the Natural History of Vulnerable Coronary Plaques

      Massachusetts General Hospital received a 2012 NIH Grant for studying the Natural History of Vulnerable Coronary Plaques

      Massachusetts General Hospital received a 2012 NIH Grant for $709,735 for studying the Natural History of Vulnerable Coronary Plaques. The principal investigator is Guillermo Tearney. The program began in 2004 and ends in 2015. Below is a summary of the work. The importance of coronary atherosclerosis and its clinical manifestations cannot be overstated; in this country, half a million people die from acute myocardial infarction every year and an equal number of patients survive with substantial morbidity. Coronary atherosclerosis is an inflammatory process governed by dysregulated endothelium, leukocytes, macrophages, and smooth muscle cells. These cells conspire to form lesions ...

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    18. Do we have a future with transcatheter adventitial delivery of stem cells?

      Do we have a future with transcatheter adventitial delivery of stem cells?

      Critically evaluating the methodology of the adventitial delivery of stem cells, some specific options should be underlined. Adventitia as the most superficial layer, consisting of connective tissue has to be distinguished of perivascular tissues. By strict definition, an adventitia is the outermost connective tissue covering any organ, or vessel. The “adventitial” delivery of stem cells with a 1 mm micro-needle means a delivery to superficial so called pericardial myocardium, perivascular fat tissues, including a risk of perforation and injury of soft tissues. In fact, the mapping of the artery with visualization of the three-layer vessel structure and perivascular tissues as ...

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    19. Association Between Proximal Stent Edge Positioning on Atherosclerotic Plaques Containing Lipid Pools and Postprocedural Myocardial Infarction (from the CLI-POOL Study)

      Association Between Proximal Stent Edge Positioning on Atherosclerotic Plaques Containing Lipid Pools and Postprocedural Myocardial Infarction (from the CLI-POOL Study)

      Postprocedural myocardial infarction is an ominous complication of percutaneous coronary intervention (PCI). Despite several patient, lesion, and procedural factors that may affect its occurrence and severity, it is unclear if implanting a stent edge on a coronary lipid pool, as appraised by optical coherence tomography (OCT), adversely affects outcomes. The aim of this study was to assess the association between postprocedural myocardial infarction and the implantation of a stent edge on a lipid pool, as assessed by OCT. A database was screened for patients without ongoing myocardial infarctions; who underwent PCI with stenting for single, native, de novo lesions; without ...

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    20. Atherosclerosis: Clinical Perspectives Through Imaging (Book)

      Atherosclerosis: Clinical Perspectives Through Imaging (Book)

      This book will be a highly practical primer for cardiologists. The text will be aimed at practicing clinicians and will rely on didactic tabular and bullet points and a host of fine imagery describing the common features of the imaging of atherosclerosis and enabling the reader to understand more about the advantages and limitations of each modality in investigating athersclosis. Edited by and contributed to by a host of international experts in cardiac imaging, this book will be destined to be a must read by all who image the heart.

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    21. Optical Coherence Tomography And Pressure Based Systems And Methods

      Optical Coherence Tomography And Pressure Based Systems And Methods

      In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly ...

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