1. Articles in category: Cardiology

    481-504 of 2383 « 1 2 ... 18 19 20 21 22 23 24 ... 98 99 100 »
    1. New Developments in Hybrid Optical Coherence Tomographic Imaging: Current Status and Potential Implications in Clinical Practice and Research

      New Developments in Hybrid Optical Coherence Tomographic Imaging: Current Status and Potential Implications in Clinical Practice and Research

      Optical coherence tomography (OCT) is a relatively new imaging technique that was introduced to overcome limitations of previous imaging modalities. OCT provides high resolution cross-sectional images of the coronaries which permit detailed evaluation of the luminal morphology and assessment of coronary artery pathology. These unique qualities render OCT a useful tool in clinical practice and research arena. However, apart from its significant advantages OCT imaging has also considerable limitations. To overcome the pitfalls of OCT, fusion of this modality with other imaging techniques has been proposed. Today several hybrid catheter and sophisticated data fusion methodologies have been developed for this ...

      Read Full Article
    2. NSF Grant Award to Christine P. Fleming Hendon from Columbia University

      NSF Grant Award to Christine P. Fleming Hendon from Columbia University

      Prof. Fleming received a two year Broadening Participation Research Initiation Grants in Engineering (BRIGE) award from the NSF. The objective of this BRIGE proposal is to develop high-resolution optical imaging and image analysis for diagnosis of diseases and therapy monitoring of the heart muscle. The aims of the project are 1) characterizing human myocardium ex vivo with optical coherence tomography imaging, 2) development of automated image processing algorithms for tissue classification, and 3) broadening participation in STEM fields through outreach to NYC high school students.

      Read Full Article
    3. Features of Coronary Plaque in Patients with Metabolic Syndrome and Diabetes Mellitus Assessed by 3-vessel Optical Coherence Tomography

      Features of Coronary Plaque in Patients with Metabolic Syndrome and Diabetes Mellitus Assessed by 3-vessel Optical Coherence Tomography

      Background —The pathophysiologic basis for the association between metabolic syndrome (MetS) and coronary artery disease is not well understood. We sought to characterize coronary plaques in patients with MetS using optical coherence tomography (OCT). Methods and Results —We identified 451 coronary plaques from 171 subjects who underwent OCT imaging in three coronary arteries. Subjects were divided into 3 groups: diabetes mellitus (DM, n=77), MetS (n=35), and a control group (C group, n=59) without DM or MetS. OCT analysis included the presence of lipid-rich plaque, maximum lipid arc, lipid-core length (LL), lipid index (LI), fibrous cap thickness (FCT ...

      Read Full Article
    4. Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system

      Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system

      A 72-year-old female with a history of sleep apnoea syndrome was referred to the Andreas Gruentzig Catheterisation Laboratories for catheter-based renal nerve ablation (RNA) due to drug-resistant, uncontrolled hypertension. After intravenously loading with aspirin, the RNA was obtained using the first generation multi-electrode EnligHTNTM system (St. Jude Medical, Westford, MA, USA) delivering 8 ablation runs on both the left and the right renal artery. Before and after the RNA procedure, optical coherence tomography (OCT) was performed using the C7-XR imaging system (LightLab Imaging, Inc., Westford, MA, USA) with a non-occlusive technique and a single-mode optical fibre catheter (frequency domain-OCT-catheter, DragonFlyTM ...

      Read Full Article
    5. Vanderbilt University Receives NIH Grant for Quantitative In Vivo Optical Imaging of Vascular Response to Hind Limb Ischemia

      Vanderbilt University Receives NIH Grant for Quantitative In Vivo Optical Imaging of Vascular Response to Hind Limb Ischemia

      Vanderbilt University Received a 2012 NIH Grant for $212,106 for Quantitative In Vivo Optical Imaging of Vascular Response to Hind Limb Ischemia. The principal investigator is Craig Duvall and Melissa Skala. The program began in 2012 and ends in 2014. Below is a summary of the work. Peripheral arterial disease (PAD) is estimated to affect as many as 20% American adults over 65 years of age and results decreased lower extremity function and overall quality of life. Therapeutic angiogenesis, stimulation of new blood vessels to replace the function of dysfunctional, diseased arteries, represents a promising, relatively new approach that ...

      Read Full Article
    6. Volcano Reports Second Quarter Results; Medical Segment Revenues Increase More Than 13 Percent On A Constant Currency Basis

      Volcano Reports Second Quarter Results; Medical Segment Revenues Increase More Than 13 Percent On A Constant Currency Basis

      Volcano Corporation (Nasdaq: VOLC), a leading developer and manufacturer of precision guided therapy tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, today reported results for the second quarter and first six months of 2013.

      For the quarter ended June 30, 2013, Volcano reported revenues of $101.3 million, an increase of six percent on a reported basis versus the same period a year ago and 12 percent on a constant currency basis after adjusting for a negative impact of approximately $5.5 million from foreign currency. Medical segment revenues increased more than seven percent ...

      Read Full Article
    7. The feasibility of optical coherence tomography guided thrombus aspiration in patients with non-ST-elevation myocardial infarction after initial conservative therapy – A pilot study

      The feasibility of optical coherence tomography guided thrombus aspiration in patients with non-ST-elevation myocardial infarction after initial conservative therapy – A pilot study

      During percutaneous coronary intervention (PCI) in patients with acute coronary syndrome balloon inflation or stent deployment leads to fragmentation of thrombus causing microembolization and myocardial damage . Manual thrombus aspiration (TA) allows effective retrievement of thrombus in 70% to 80% of patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) .

      Read Full Article
    8. Feature Of The Week 8/4/13: MGH OCT Registry Reports on In Vivo OCT Studies of Plaque Erosion and Calcified Nodule In Acute Coronary Syndrome

      Feature Of The Week 8/4/13: MGH OCT Registry Reports on In Vivo OCT Studies of Plaque Erosion and Calcified Nodule In Acute Coronary Syndrome

      Pathology studies reported that three most common causes of acute coronary syndrome (ACS) or sudden cardiac death are plaque rupture, plaque erosion and calcified nodules. The morphological and clinical characteristics of the underlying pathology of ACS, especially plaque erosion and calcified nodule, have never been well studied in vivo. Using optical coherence tomography, we found that plaque erosions are the substrate for ACS in 31% of patients and calcified nodules in 8% of patients, which are consistent with pathological findings. Erosions are more likely to cause non-ST-segment elevation ACS than ST-segment elevation myocardial infarction. Compared to plaque rupture, plaque erosion ...

      Read Full Article
    9. Stent Evaluation with Optical Coherence Tomography

      Stent Evaluation with Optical Coherence Tomography

      Optical coherence tomography (OCT) has been recently applied to investigate coronary artery disease in interventional cardiology. Compared to intravascular ultrasound, OCT is able to visualize various vascular structures more clearly with higher resolution. Several validation studies have shown that OCT is more accurate in evaluating neointimal tissue after coronary stent implantation than intravascular ultrasound. Novel findings on OCT evaluation include the detection of strut coverage and the characterization of neointimal tissue in an in-vivo setting. In a previous study, neointimal healing of stent strut was pathologically the most important factor associated with stent thrombosis, a fatal complication, in patients treated ...

      Read Full Article
    10. Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study

      Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study

      Subjects presenting with probable acute coronary syndromes scheduled for cardiac catheterization will be enrolled in this study. Consented subjects will be randomized to receive ticagrelor started with a loading dose immediately after enrollment versus receiving a loading dose of ticagrelor during cardiac catheterization after diagnostic angiography but prior to stenting. Optical coherence tomography (OCT) will be performed after stenting and the volume of thrombus within the new stent will be measured and compared between the groups.

      Read Full Article
    11. Optical coherence tomography analysis of strut coverage in biolimus- and sirolimus-eluting stents: 3-month and 12-month serial follow-up

      Optical coherence tomography analysis of strut coverage in biolimus- and sirolimus-eluting stents: 3-month and 12-month serial follow-up

      Background No randomized studies have been conducted to investigate serial changes in optical coherence tomography (OCT) analyses following implantation of biolimus-A9-eluting stents (BES) and sirolimus-eluting stents (SES). Methods A total of 60 patients fulfilling the study criteria were randomly assigned into BES ( n = 30) and SES ( n = 30) implantation groups. Serial OCT evaluation at post-procedure, 3- and 12-months follow-up was performed in 46 patients [BES ( n = 22) and SES ( n = 24)]. OCT analyses were compared according to the type of stents and the follow-up time intervals. The percentage of uncovered struts was defined as the ratio of uncovered struts to ...

      Read Full Article
    12. Correlation Between Degree of Neointimal Hyperplasia and Incidence and Characteristics of Neoatherosclerosis as Assessed by Optical Coherence Tomography

      Correlation Between Degree of Neointimal Hyperplasia and Incidence and Characteristics of Neoatherosclerosis as Assessed by Optical Coherence Tomography

      Emerging evidence suggests that neointimal degenerative changes with development of neoatherosclerosis (NA) may represent an important mechanism for late stent failure. The aim of the present study was to investigate the relation between degree of neointimal hyperplasia and incidence and characteristics of NA using optical coherence tomography. We identified a total of 252 stents with mean neointimal thickness (NIT) >100 μm in 212 patients: 100 bare metal stents (BMSs) and 152 drug-eluting stents (DESs). Based on the values of mean NIT, we divided stents into tertiles and compared neointimal characteristics among the 3 groups. NA was defined as the presence ...

      Read Full Article
    13. The invasive assessment of coronary atherosclerosis and stents using optical coherence tomography: a clinical update

      The invasive assessment of coronary atherosclerosis and stents using optical coherence tomography: a clinical update

      Ischaemic heart disease (IHD) remains one of the leading causes of death. Atherosclerosis has been intensely researched given the IHD prevalence and the financial impacts on healthcare systems. More recently, in vivo characterisation of coronary atherosclerotic plaque and tissue responses following stent implantation in a coronary artery has been made possible by a novel technology called optical coherence tomography (OCT). OCT is a light-based, invasive, intracoronary imaging modality long applied to the field of ophthalmology and now in clinical use worldwide. It gives a unique view of within the coronary artery using near-infrared light with a resolution of 15 microns ...

      Read Full Article
    14. Automatic characterization of neointimal tissue by intravascular optical coherence tomography

      Automatic characterization of neointimal tissue by intravascular optical coherence tomography

      Intravascular optical coherence tomography (IVOCT) is rapidly becoming the method of choice for assessing vessel healing after stent implantation due to its unique axial resolution < 20     μ m . The amount of neointimal coverage is an important parameter. In addition, the characterization of neointimal tissue maturity is also of importance for an accurate analysis, especially in the case of drug-eluting and bioresorbable stent devices. Previous studies indicated that well-organized mature neointimal tissue appears as a high-intensity, smooth, and homogeneous region in IVOCT images, while lower-intensity signal areas might correspond to immature tissue mainly composed of acellular material. A new method for automatic ...

      Read Full Article
    15. First-in-human description of everolimus-eluting bioabsorbable vascular scaffold implantation for the treatment of drug-eluting stent failure: Insights from optical coherence tomography

      First-in-human description of everolimus-eluting bioabsorbable vascular scaffold implantation for the treatment of drug-eluting stent failure: Insights from optical coherence tomography

      Drug-eluting stents (DES) markedly reduce new episodes of revascularization compared with bare-metal stents; nevertheless, the prevalence of DES in-stent restenosis (ISR) is not insignificant as a large population is treated with these devices worldwide . In addition, concerns regarding long-term safety of metallic DES stimulated investigators to seek for improvement of this therapy. Everolimus-eluting bioabsorbable vascular scaffolds (BVS, Abbott Vascular, Santa Clara, CA, USA) emerged as an interesting alternative, as they enable vessel scaffolding in short-term and anti-restenotic drug delivery, while avoiding long-term limitations of metallic DES (i.e., prolonged metal exposure to coronary circulation in case of delayed healing). Indeed ...

      Read Full Article
    16. Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography

      Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography

      Since the emergence of biabsorbable vascular scaffolds (BVS), treatment of bifurcation lesions with these devices has remained a source of question. Although SB dilatation has been previously performed with BVS, it is not yet clear how dilatation across BVS strut may impact scaffold structure. A 74-year-old lady with hypercholesterolaemia and …

      Read Full Article
    17. Automatic assessment of stent neointimal coverage by intravascular optical coherence tomography

      Automatic assessment of stent neointimal coverage by intravascular optical coherence tomography

      Aims This study aimed to validate automatic intravascular optical coherence tomography (IVOCT) analysis for the evaluation of neointimal coverage in response to stent implantation. Methods and results Fourteen stented segments in common iliac arteries, acquired from a total of seven adult male New Zealand White rabbits, were interrogated in vivo by IVOCT. Durable polymer everolimus-eluting stents (EES; Xience V, Abbott Vascular, Santa Clara, CA, USA) were used exclusively. Comparison with histology was made in a total of 63 pairs of images, where neointimal thickness over corresponding individual stent struts was assessed. A high correlation coefficient ( R = 0.85, P < 0 ...

      Read Full Article
    18. Two-week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus-eluting stent

      Two-week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus-eluting stent

      Objective : To obtain imaging evidence by 2-week optical coherence tomography (OCT) on the completion of neointimal coverage (NIC; the percentage of stent strut coverage and thickness of the formed neointima) completion after implantation of the Endeavor zotarolimus-eluting stent (E-ZES). Background : Despite the fact that NIC is a cardinal process in the pathomechanism of late stent thrombosis, little imaging information is available on morphological changes thereof on a short-time interval basis. Methods : 27 Japanese patients with stable angina pectoris and de novo native coronary artery lesions were enrolled, and 27 lesions (30 implantations) were examined. OCT was performed at weeks 2 ...

      Read Full Article
    19. Forward looking imaging guidewire

      Forward looking imaging guidewire

      The systems and methods described herein provide for a forward looking guidewire having a reduced radial cross-section for increased maneuverability and use of the guidewire within more narrow vasculature. The guidewire can include an elongate tubular member having a distal region, proximal region and inner lumen and a forward looking imaging device coupled with the distal end of the guidewire. The distal region of the guidewire can be relatively more flexible than the proximal region. The guidewire can also include a second, side looking imaging device, which can be coupled around a longitudinal portion of the guidewire in the radial ...

      Read Full Article
    20. Incidence, Predictors, Morphological Characteristics, and Clinical Outcomes of Stent Edge Dissections Detected by Optical Coherence Tomography

      Incidence, Predictors, Morphological Characteristics, and Clinical Outcomes of Stent Edge Dissections Detected by Optical Coherence Tomography

      Objectives This study sought to investigate the frequency, predictors, and detailed qualitative and quantitative assessment of optical coherence tomography (OCT)-detected stent edge dissections. Its impact on subsequent management and clinical outcomes were also investigated. Background OCT is a high-resolution imaging modality that can lead to more frequent recognition and accurate assessment of vascular injuries during percutaneous coronary intervention (PCI). Methods From September 2010 to June 2011, all patients with OCT post-PCI were enrolled. Edge dissections were defined as disruptions of the arterial lumen surface in both the 5-mm distal and proximal stent edges. Qualitative and quantitative analyses of all ...

      Read Full Article
    21. Optical Coherence Tomography – 15 Years in Cardiology –

      Optical Coherence Tomography – 15 Years in Cardiology –

      Since its invention in the late 1990s, intravascular optical coherence tomography (OCT) has been rapidly adopted in clinical research and, more recently, in clinical practice. Given its unprecedented resolution and high image contrast, OCT has been used to visualize plaque characteristics and to evaluate the vascular response to percutaneous coronary intervention. In particular, OCT is becoming the standard modality to evaluate in vivo plaque vulnerability, including the presence of lipid content, thin fibrous cap, or macrophage accumulation. Furthermore, OCT findings after stent implantation, such as strut apposition, neointimal hyperplasia, strut coverage, and neoatherosclerosis, are used as surrogate markers of the ...

      Read Full Article
    22. Frequency-domain optical coherence tomography assessment of kissing-balloon effects in bifurcated coronary artery lesions undergoing provisional stenting - Corrected Proof

      Frequency-domain optical coherence tomography assessment of kissing-balloon effects in bifurcated coronary artery lesions undergoing provisional stenting - Corrected Proof

      Stenoses located at bifurcations represent a challenging subset of coronary lesions which may benefit from invasive imaging and optical coherence tomography (OCT) has been recognized to have a promising role in this setting . Provisional-T-stenting with drug-eluting stents (DES) represents the gold standard for percutaneous treatment of bifurcated lesions but the usefulness of final kissing balloon inflation (FKI) is not established. Indeed, in a dedicated trial, FKI has not been found to improve clinical outcome even if it provides better SB ostium angiographic results .

      Read Full Article
    481-504 of 2383 « 1 2 ... 18 19 20 21 22 23 24 ... 98 99 100 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (3 articles) Harvard University
    2. (2 articles) Erasmus University
    3. (2 articles) Yonsei University
    4. (2 articles) Massachusetts General Hospital
    5. (2 articles) Brigham and Women’s Hospital
    6. (1 articles) University of Cantabria
    7. (1 articles) Sungkyunkwan University
    8. (1 articles) University of London
    9. (1 articles) University of Padova
    10. (1 articles) Kawasaki Medical School
    11. (1 articles) University of Texas Health Science Center
    12. (1 articles) University of Iowa
  4. People in the News

    1. (2 articles) Yangsoo Jang
    2. (2 articles) Hector M. Garcia-Garcia
    3. (2 articles) Ik-Kyung Jang
    4. (1 articles) John A. Ormiston
    5. (1 articles) Tsunenari Soeda
    6. (1 articles) Jurgen M. Ligthart
    7. (1 articles) Stephan Windecker
    8. (1 articles) Martin J. Leahy
    9. (1 articles) Kazushige Kadota
    10. (1 articles) Haroon Zafar
    11. (1 articles) Patrick W. Serruys
    12. (1 articles) Yoshinobu Onuma
  5. OCT Companies in the News

    1. (1 articles) Volcano Corporation