1. Articles in category: Cardiology

    4249-4272 of 4340 « 1 2 ... 175 176 177 178 179 180 181 »
    1. Thinking inside the graft: applications of optical coherence tomography in coronary artery bypass grafting

      Emile N. Brown, Nicholas S. Burris, Junyan Gu et al. Recent advances in catheter-based optical coherence tomography (OCT) have provided the necessary resolution and acquisition speed for high-quality intravascular imaging. Complications associated with clearing blood from the vessel of a living patient have prevented its wider acceptance. We identify ... [J. Biomed. Opt. 12, 051704 (2007)] published Wed Oct 24, 2007.
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    2. In Vivo Optical Coherence Tomography (OCT) of Experimental Thrombosis in a Rabbit Carotid Model

      Background Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes. Thus, direct thrombus visualization in vivo may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of imaging acute thrombosis in vivo using OCT, in an experimental thrombosis animal model. Methods and Results Nine male New Zealand White rabbits (weight, ¡Ö3.0 kg) were made atherosclerotic with a high-cholesterol diet after injury of the right carotid artery endothelium. Thrombus was then induced with the use of Russell's viper venom (RVV) and histamine. Subsequently, OCT imaging of ...
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    3. Device and method for inducing vascular injury and/or blockage in an animal model

      Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of the blood-brain barrier in individual, specifically-targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above and directly below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics ...
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    4. Stent with anchors to prevent vulnerable plaque rupture during deployment

      A stent for implantation in a body lumen for protecting from rupture a fibrous cap in order to treat vulnerable plaque. One embodiment of the stent achieves staged expansion through stronger and weaker circumferential regions, and includes optional anchors positioned at the circumferential transition between the stronger and weaker regions. During the first stage expansion, the weaker region expands moving the anchors laterally apart. The anchors straddle the fibrous cap and embed into the vessel wall. The second stage expansion of the stent exerts gentler stresses by the weaker region against the fibrous cap while the stronger region exerts greater ...
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    5. Flush catheter with flow directing sheath

      A flush catheter is provided which is configured to be introduced into an orifice to create a flush zone therein. The flush catheter includes a catheter body having an inner cavity, the inner cavity being configured to communicate with a source of flush solution, one or more openings configured to expel therethrough flush solution, and a sheath at least partially covering the one or more openings, wherein when flush solution is expelled through the one or more openings, the flush solution is directed by the sheath to flow along an outer surface of the catheter body, thereby creating a flush ...
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      Mentions: Abbot
    6. Low coherence interferometry for detecting and characterizing plaques

      A method for determining a characteristic of tissue in a biological sample comprising: directing light at the biological sample at a first depth and receiving that light reflected from the biological; directing the light at a reflecting device and receiving that light reflected from the reflecting device. The method also includes: interfering the light reflected from the biological sample and the light reflected from the reflecting device; detecting light resulting from the interfering; and determining a first phase associated with the light resulting from the interfering based on the first depth. The method further includes: varying an effective light path ...
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    7. Device for performing laser angioplasty with OCT monitoring

      Device for performing laser angioplasty, in which laser light is beamed via a laser radiation device in the area of a catheter tip, with simultaneous OCT monitoring, for the ablation of plaque. The feed lines for the laser radiation device and the rotating OCT signal lines are disposed in a common catheter sheath, said feed lines leading to an OCT sensor disposed within a ring-shaped window running around the circumference of the catheter sheath, said OCT sensor being disposed at a distance from the laser radiation device.
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      Mentions: Siemens
    8. Optical coherence tomography after cutting balloon angioplasty

      Optical coherence tomography (OCT) is a recently developed optical imaging technique that provides high-resolution (approximately 10–20 µm) cross-sectional images of vessels. A 74-year-old man was admitted for chest pain. A coronary angiogram showed diffuse in-stent restenosis of an Express (Boston Scientific Corporation and Medinol Ltd) 2.75 x 15 mm stent which had been implanted in the left anterior descending coronary artery six months earlier (panel A; arrow). Using OCT (Image Wire, LightLab Imaging, Inc) imaging, well-apposed stent struts and neointima formation around the stent were clearly visualised (panel B). We performed angioplasty by using Cutting Balloon Ultra (Boston ...
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    9. Safety and feasibility of a new non-occlusive technique for facilitated intracoronary optical coherence tomography (OCT) acquisition in various clinical and anatomical scenarios

      Safety and feasibility of a new non-occlusive technique for facilitated intracoronary optical coherence tomography (OCT) acquisition in various clinical and anatomical scenarios
      To facilitate OCT images acquisition we developed a novel, simplified, non-occulsive technique based on manual infusion of a viscous isosmolar solution. The aims of the present study was to address the safety and efficacy of non-occulsive OCT images acquisition modality in a patient population with comples coronary lesions, and in various clinical sceanarios.
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    10. System and method for vascular border detection

      A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border (e.g., tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device (e.g., an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device ...
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    11. Robust intravascular optical coherence elastography by line correlations

      Abstract. We present a new method for intravascular optical coherence elastography, which is robust against motion artefacts. It employs the correlation between adjacent lines, instead of subsequent frames. Pressure to deform the tissue is applied synchronously with the line scan rate of the optical coherence tomography (OCT) instrument. The viability of the method is demonstrated with a simulation study. We find that the root mean square (rms) error of the displacement estimate is 0.55 µm, and the rms error of the strain is 0.6%. It is shown that high-strain spots in the vessel wall, such as observed at ...
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    12. Optical Coherence Tomography in Cardiovascular Research (Book)

      Optical Coherence Tomography in Cardiovascular Research (Book)
      Introducing the cardiovascular application of this technology, Handbook of Optical Coherence Tomography in Cardiovascular Research is a unique publication that presents the reader with the basic background to OCT and its role in the diagnosis and management of coronary artery disease. Presenting a concise overview of the current state of the art of vascular OCT imaging, and shedding light on a variety of exciting new developments, Handbook of Optical Coherence Tomography in Cardiovascular Research is a highly useful resource for researchers and clinicians involved in the field of atherosclerosis.
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    13. Instrumented catheter with distance compensation to sense vulnerable plaque

      A method and apparatus for determining vulnerable plaque in a cardiovascular lumen is disclosed. In one embodiment, a guide member comprising a temperature sensor and a distance sensor are inserted into the cardiovascular lumen. The temperature of the cardiovascular wall is measured with the temperature sensor, and the distance from the temperature sensor to the cardiovascular wall is determined. The cardiovascular wall temperature is adjusted based on the distance determination, and the vulnerable plaque is determined based on the adjusted wall temperature measurement.
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    14. Coated medical devices for the treatment of vulnerable plaque

      Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. In addition to reducing or substantially eliminating a biological organism's reaction to the introduction of the medical device to the organism, the medical device in combination with one or more therapeutic drugs, agents ...
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      Mentions: Cordis
    15. Optical Coherence Tomography (OCT) Imaging of Post Coil Aneurysm Healing.

      At Beckman Laser Institute, University of California, Irvine, we have developed diagnostic device call 'Optical Coherence tomography (OCT).' OCT is an imaging technique capable of performing high-resolution,cross-sectional imaging. OCT enables real-time, in situ visualization of tissue microstructure without the need to excise and process the specimen as required for conventional biopsy and histopathology. OCT is analogous to ultrasound except that imaging is performed with light instead of acoustic waves. OCT measures light reflected from turbid structures. Consequently, OCT is a powerful method to image biological tissue in-vivo at high resolution. The objective of the study is to demonstrate a ...
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    16. Blood-flow-occluding, temperature-sensing catheters and methods of use

      A catheter assembly for sensing the temperature of an arterial wall or other body lumen includes a blood-flow-occluding feature to increase the accuracy of the temperature measurements. In addition to the flow-occluding feature, the catheter includes a distal end with a temperature sensing structure and a proximal end including a manually operated expansion control. The temperature sensing structure including one or more presentation elements in the form of a basket or braided structure having at least one temperature sensor supported thereon, each sensor being operative to generate an electrical signal indicative of temperature. The presentation elements are physically coupled to ...
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    17. Optical apparatus for detecting and treating vulnerable plaque

      An optical apparatus and methods for monitoring temperature enabling detection and treatment of a vulnerable plaque of a patient comprising an elongate catheter, a plurality of outer optical fibers deployably disposed within the lumen of the catheter and suitably expandable in an outwardly radial manner configured for forming a basket shape, the outer fibers having at least one optical grating along an axis of the fiber wherein the at least one optical grating reflects a certain wavelength or intensity of the light beam, the certain wavelength or intensity of the reflected light beam being correlated to known temperature, and a ...
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    18. Catheter

      An ultrasound catheter includes a transducer unit used for observation of the inside of an organism, observation lumens in which the transducer unit is disposed and which extend in the direction of insertion into the organism, a first guide wire lumen provided substantially in parallel to the observation lumens and on the distal end side in the insertion direction in relation to the transducer unit and through which a guide wire preliminarily brought to the inside of the organism is passed, and a second guide wire lumen provided on an extension line of the first guide wire lumen and on ...
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    19. Quantification of glucose diffusion in arterial tissues by using optical coherence tomography

      Several investigations suggest that the early stages of atherosclerosis are modulated by the selective permeability of the vascular tissue to pro-inflammatory molecules of different molecular weights. Up to date, a few experiments have been performed to study the permeability of arterial tissue to different molecules. This is primarily due to an absence of an experimental technique capable of depth-resolved, accurate and sensitive assessment of arterial permeability. In this paper, we report our pilot results on nondestructive quantification of glucose diffusion in animal arteries in vitro by using optical coherence tomography (OCT) technique. Permeability of glucose in animal's aorta was ...
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    20. Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces

      Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces
      A new optical imaging technique, developed at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH), can provide three-dimensional microscopic views of the inner surfaces of blood vessels and gastrointestinal organs. In their report in the journal Nature Medicine, receiving early online release today, the MGH-Wellman researchers describe using optical frequency-domain imaging (OFDI) to visualize broad areas of the esophagus and coronary arteries of living pigs. The technique is an advance over optical coherence tomography (OCT) -- another noninvasive MGH-developed technology that details much smaller areas -- and could be useful for identifying precancerous lesions and dangerous deposits of plaque in ...
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    21. Comprehensive volumetric optical microscopy in vivo

      Comprehensive volumetric optical microscopy in vivo
      Comprehensive volumetric microscopy of epithelial, mucosal and endothelial tissues in living human patients would have a profound impact in medicine by enabling diagnostic imaging at the cellular level over large surface areas. Considering the vast area of these tissues with respect to the desired sampling interval, achieving this goal requires rapid sampling. Although noninvasive diagnostic technologies are preferred, many applications could be served by minimally invasive instruments capable of accessing remote locations within the body. We have developed a fiber-optic imaging technique termed optical frequency-domain imaging (OFDI) that satisfies these requirements by rapidly acquiring high-resolution, cross-sectional images through flexible, narrow-diameter ...
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    22. Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition and display

      A multifunctional invasive cardiovascular diagnostic measurement host is disclosed that interfaces a variety of sensor devices, such as guide wire-mounted pressure sensors, flow sensors, temperature sensors, etc, and provides a multi-mode graphical user interface providing a plurality of displays in accordance with the various types of sensors and measurements rendered by the sensors.
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    23. System and method for assessing catheter connection using return loss

      A system for assessing the quality of the optical connection between a catheter and a console is described that avoids the necessity of a calibration port, although one can still be provided if desired. It operates by monitoring the level of light returning from the catheter head and specifically the degree to which this returning light is attenuated. Reflections will arise at the catheter head's optical window due to the discontinuity between the refractive index of the window and that of air or other medium into which the head is inserted. Since the refractive index of the optical window ...
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    4249-4272 of 4340 « 1 2 ... 175 176 177 178 179 180 181 »
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