1. Articles in category: Cardiology

    3817-3840 of 4007 « 1 2 ... 157 158 159 160 161 162 163 ... 165 166 167 »
    1. In vivo optical coherence tomography of experimental thrombosis in a rabbit carotid model

      In vivo optical coherence tomography of experimental thrombosis in a rabbit carotid model

      Background:Plaque rupture with subsequent thrombosis is recognised as the underlying pathophysiology of most acute coronary syndromes. Thus, direct thrombus visualisation in vivo may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of imaging acute thrombosis in vivo using optical coherence tomography (OCT) in an experimental thrombosis animal model.Methods and results:Nine male New Zealand White rabbits (weight 3.0 kg) were made atherosclerotic with a high-cholesterol diet after injury of the right carotid artery endothelium. Thrombus was then induced with the use of Russell’s viper venom (RVV) and histamine. Subsequently ...

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    2. David W. Kolstad appointed President and Chief Executive Officer of LightLab Imaging

      David W. Kolstad appointed President and Chief Executive Officer of LightLab Imaging Westford, MA – May 8, 2008 – LightLab Imaging, Inc., the world leader in photonic imaging technologies for medical applications, today announced the appointment of Mr. David W. Kolstad as Chief Executive Offic
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    3. Volcano Corp Announces First Human Use of the Volcano Optical Coherence Tomography (OCT) Imaging Catheter

      New imaging modality highlights Volcano commitment to intravascular imaging and opens up new clinical and research applications SAN DIEGO and BRUSSELS, Belgium, May 8 /- Volcano Corporation (Nasdaq: VOLC ), a leading manufacturer and developer of intravascular ultrasound (IVUS), functional measurement (FM) and Optical Coherence Tomography (OCT) products designe...
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    4. Volcano Announces Participation in Saturn Clinical Trial Sponsored by AstraZeneca

      Study represents first inclusion of Volcano Revolution(R) 45 MHz IVUS Imaging Catheter in large-scale pharmaceutical plaque progression trial. SAN DIEGO, May 5 (HSMN NewsFeed) -- Volcano Corporation (Nasdaq: VOLC ), a leading manufacturer and develope... Devices, Interventional Volcano, intravascular ultrasound, SATURN, Volcano Revolution
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    5. Novelties in cardiac imaging – Optical Coherence Tomography (OCT)

      Novelties in cardiac imaging – Optical Coherence Tomography (OCT)

      In order to improve our understanding of late stent thrombosis an dto access the individual risk of a patient or lesion, there is clinical need to assess vascular healing after stenting in vivo. We will discuss the potential and limitations of Optical Coherence Tomography (OCT) for imaging of drug eluting stents (DES).

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    6. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma

      Aims To evaluate the feasibility of the combined use of virtual histology (VH)-intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for detecting in vivo thin-cap fibroatheroma (TCFA). Methods and results In 56 patients with angina, 126 plaques identified by IVUS findings were analysed using both VH-IVUS and OCT. IVUS-derived TCFA was defined as an abundant necrotic core (>10% of the cross-sectional area) in contact with the lumen (NCCL) and %plaque-volume >40%. OCT-derived TCFA was defined as a fibrous cap thickness of Conclusion Neither modality alone is sufficient for detecting TCFA. The combined use of OCT and VH-IVUS might be ...
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    7. From Bench to Bedside - A Novel Technique of Acquiring OCT Images

      Background Optical coherence tomography (OCT), a high resolution intravascular imaging technique, requires blood displacement for reliable image acquisition and the current technique uses a soft occlusion balloon plus saline injection in the coronary artery. A non-occlusive technique based on manual infusion of a viscous iso-osmolar solution has been developed and tested and validated through a 2-phase study. Methods and Results OCT assessment was performed with the M2 LightLab OCT (LightLab Imaging, Westford, MA, USA) image-wire in 3 swine by infusing 30 ml of each of 3 solutions differing in viscosity, osmolarity and electrolytic composition (A: iodixanol 320 and Lactated Ringer ...
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    8. Optical clearing of flowing blood using dextrans with spectral domain optical coherence tomography

      Xiangqun Xu, Lingfeng Yu, and Zhongping Chen Spectral domain optical coherence tomography (SDOCT) images have been used to investigate the mechanism of optical clearing in flowing blood using dextrans. The depth reflectivity profiles from SDOCT indicate that dextrans become increasingly more effective in reducing scattering in flowing blood, e ... [J. Biomed. Opt. 13, 021107 (2008)] published Tue Apr 29, 2008.
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    9. Device and method for combining a treatment agent and a gel

      A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first ...
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    10. Seminar on Intravascular Imaging with Optical Coherence Tomography

      2:45pm-3:45pm Intravascular Imaging with Optical Coherence Tomography (OCT), with Dr. Joseph M. Schmitt, Chief Technical Officer, LightLab Imaging Abstract: The introduction of optical coherence tomography (OCT) into the marketplace for ophthalmic imaging marks the successful transfer of a new imaging technology from the research bench to the patient's bedside. This talk will trace the development of an important new emerging application of OCT: imaging inside the coronary arteries. The talk wil
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    11. System and method for identifying a vascular border (IVUS)

      A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention ...
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    12. Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography

      Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography
      Objective: To analyse the neointimal coverage of sirolimus-eluting stent (SES) and bare-metal stent (BMS) visualised in vivo by optical coherence tomography (OCT). Methods: OCT images were obtained in 26 coronary vessels of 24 patients at 5–93 months after SES or BMS deployment. The short-term BMS group (BMS1) consisted of eight BMS in seven patients at 5–10 months of follow-up, the long-term BMS group (BMS2) consisted of six BMS in six patients at 23–93 months of follow-up, and the SES group (SES) consisted of 13 SES in 10 patients at 6–12 months of follow-up. The strut apposition ...
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    13. Identification of multiple plaque ruptures by optical coherence tomography in a patient with acute myocardial infarction: a three-vessel study

      Optical coherence tomography (OCT) is a new imaging modality capable of obtaining cross-sectional images of coronary vessels with a high resolution of about 10 µm, which is about 10-fold greater than that of intravascular ultrasound. A 57-year-old man was admitted to our hospital with acute posterior myocardial infarction. An emergency coronary angiography demonstrated 99% stenosis (TIMI 2 flow) in segment 11 of the left circumflex artery, and 75% stenosis in segment 3 of the right coronary artery, but no significant stenosis in the left anterior descending coronary artery (panels A, F). Thin-cap fibroatheroma (TCFA; panel B), plaque rupture (panel C ...
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    14. Various optical coherence tomographic findings in restenotic lesions after sirolimus-eluting stent implantation

      In-stent restenosis (ISR) after sirolimus-eluting stent (SES) implantation rarely occurs, and these lesions are commonly recognized as focal restenosis on angiograms. Optical coherence tomography (OCT) is able to distinguish from several components of intracoronary structures by different signal patterns. We herein report three cases of various OCT images from ISR lesions in spite of similar angiographic findings. Our OCT findings suggested that ISR lesions that develop after SES implantation might be composed of not uniform but various tissues.
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    15. Optical coherence tomography: High resolution intravascular imaging to evaluate vascular healing after coronary stenting

      The risk of late stent thrombosis represents a major concern for patients treated with drug-eluting stents (DES). Delayed healing and incomplete stent coverage were commonly observed in pathologic specimens of vessels treated with DES. In-situ assessment of the stent coverage has been limited by the low spatial resolution of current image modalities. Optical coherence tomography (OCT) enables real-time, full tomographic, in-vivo visualization of coronary vessel microstructure. Struts coverage and vessel response of DES compared to BMS are the most immediate clinical applications of OCT. Thickness of coverage and strut apposition can be quantified at micron-scale level with a resolution 10-30 ...
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    16. Medical companies take 'Fantastic Voyage' into heart

      NEW YORK (CNNMoney.com) -- The trouble with drug-coated stents could be a boon to Volcano and other companies specializing in high-tech heart screening that could have been dreamed up in the sci-fi classic "Fantastic Voyage." Volcano (down $0.06 to $18.85, Charts), which went public last year, makes catheters that snake through arteries and take ultrasound pictures. But instead of Raquel Welch in a space suit, the Volcano cameras take color images of stents and cholesterol build-up. The catheter can be used to assess whether stents have been properly placed and to detect clogged arteries. Raquel Welch and company ...
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      Mentions: Scott Huennekens
    17. Evaluation of intracoronary stenting by intravascular optical coherence tomography

      Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Background: Conventional contrast cineangiography and intravascular ultrasound (IVUS) provide a limited definition of vessel microstructure and are unable to evaluate dissection, tissue prolapse, and stent apposition on a size scale less than 100 µm. Objective: To evaluate the use of intravascular optical coherence tomography (OCT) to assess the coronary arteries in patients undergoing coronary stenting. Methods: OCT was employed in patients having percutaneous coronary interventions. Images were obtained before initial balloon dilatation and following stent deployment, and were evaluated for vessel dissection, tissue prolapse, stent apposition ...
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    3817-3840 of 4007 « 1 2 ... 157 158 159 160 161 162 163 ... 165 166 167 »
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