1. Articles in category: Cardiology

    3793-3816 of 3851 « 1 2 ... 156 157 158 159 160 161 »
    1. 4D embryonic cardiography using gated optical coherence tomography

      4D embryonic cardiography using gated optical coherence tomography
      Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 μm), and with a depth penetration of 1.5 - 2.0 mm that is suitable for the study of early embryonic hearts. We acquired data from paced, excised, embryonic chicken and mouse hearts using gated sampling and employed image processing techniques to visualize the hearts in 4D and measure physiologic parameters such as cardiac volume, ejection ...
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    2. Methods for forming an optical window for an intracorporeal device and for joining parts

      Optical windows for intracorporeal devices, intracorporeal devices comprising a window and a method for forming a window for an intracorporeal device are provided. The method comprises placing within a mold an assembly comprising a mandrel located within a pair of parts separated by a collar of window material, heating the window preform effective to cause the window material to soften, and applying force to urge together the pair of parts to deform the window material so as to form a window. The intracorporeal devices, such as imaging devices, include guidewires, catheters, endoscopes. In addition, the method is suitable for joining ...
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    3. Method of treating vulnerable plaque

      A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment ...
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    4. Cryotherapy method for detecting and treating vulnerable plaque

      Methods, apparatus, and kits detect and/or treat vulnerable plaque of a blood vessel. A temperature differential can be sensed along a lumen surface with temperature sensors on a balloon filled with warm gas. Treatment methods include controlled and safe cryogenic cooling of vulnerable plaque to inhibit release of retained fluid within the vulnerable plaque so as to inhibit acute coronary syndrome and to help maintain patency of a body lumen.
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    5. Cordis Corporation Acquires LuMend, Inc.

      Warren, NJ (September 28, 2005) – Cordis Corporation, a Johnson & Johnson company, today announced the acquisition of LuMend, Inc., a privately held company focused on the development of chronic total occlusion (CTO) devices to treat peripheral vascular disease. A CTO is a complete or partial blockage of an artery that can lead to surgery or lower extremity amputation. Symptoms of an occlusion in the lower limbs, the most common location, are similar to other types of vessel blockages, and may include leg pain, limping, inability to walk and sores and infections that won't heal. Treatments for CTOs range from medication ...
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    6. Laser treatment of cutaneous vascular lesions

      Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion. Blood flow velocity is slowed within the region using the hyperosmotic agent, and the lesion is exposed to laser radiation.
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    7. Estimation of nonlinear mechanical properties of atherosclerotic plaques (Thesis)

      Estimation of nonlinear mechanical properties of atherosclerotic plaques (Thesis)
      A numerical method has been developed to estimate the mechanical properties of atherosclerotic plaques by combining genetic algorithm with finite element methods. Plaque images derived from optical coherence tomography were employed to construct finite element models which were subsequently used in conjunction with a genetic algorithm to determine the parameters in a nonlinear constitutive model. A new multi-frame scheme is introduced to better perform the estimation on a nonlinear mechanical model and reduce the effects of noise. Results show while it is feasible to estimate the nonlinear mechanical properties of plaque, the accuracy can depend on various factors, especially the ...
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    8. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

      We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.
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    9. Stent for treating vulnerable plaque

      An intravascular stent is configured for asymmetrical differential deployment and to align with a fibrous cap to treat vulnerable plaque. The stent is configured so that reduced expansion forces are imparted during deployment to the fibrous cap, thereby reducing the likelihood of cap rupture. The stent includes cylindrical rings connected by links and a cover attached to a portion of the stent to differentially restrict stent expansion when the stent is expanded from a delivery diameter to an implanted diameter thereby creating asymmetrical circumferential deployment. The portion of the stent having the cover imparts lower expansion forces from the stent ...
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    10. Fluid exchange system for controlled and localized irrigation and aspiration

      The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically ...
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    11. Medical scanning system and related method of scanning

      The present invention is directed to a scanning system that uses uniform rotary motion of an optical reflector to create reciprocal linear scanning. The system converts uniform rotation into uniform longitudinal scanning. The system thereby creates mechanical reciprocal linear scanning free of reciprocally moving mechanical parts common in conventional scanning systems. In a preferred embodiment of the invention, the scanning system is incorporated within an imaging catheter for medical scanning. The optical reflector is rotatable and includes a spiral reflecting portion. The spiral reflecting portion may be a single uniform reflecting surface or may include several reflection surfaces arranged in ...
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    12. Catheter with protective sleeve

      A device for accessing the spinal canal of a patient includes an introducer and a protective sleeve that is attached at one end thereof to a proximal end of the introducer. The protective sleeve has an outer stationary portion and an inner moveable portion. The outer and inner portions of the protective sleeve are separated by a crown region. A catheter is disposed inside the protective sleeve. During operation, the protective sleeve is advanced within the spinal canal to form a protective barrier between the catheter and the spinal cord. The catheter is advanced and retracted within the protective sleeve.
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    13. Fluid exchange system for controlled and localized irrigation and aspiration

      The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically ...
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    14. Terumo, Massachusetts General Hospital to Co-develop Optical Coherence Tomography

      Print | Email | Alerts Tokyo, Dec 14, 2004 (JCN) - Terumo (TSE: 4543) has announced that it has entered into a joint development agreement with the Massachusetts General Hospital. Under the terms of the agreement, the two parties will develop an optical coherence tomography (OCT) system designed for the diagnosis of coronary artery diseases. The new system will accurately identify unstable plaques found
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    15. Methods and apparatus for in vivo identification and characterization of vulnerable atherosclerotic plaques

      Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric ...
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    16. Elastography of coronary vessels using optical coherence tomography (Thesis)

      Elastography of coronary vessels using optical coherence tomography (Thesis)
      Atherosclerosis is an inflammatory disease characterized by an accumulation of lipid and fibrous tissue in the arterial wall. Postmortem studies have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid=rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex vivo plaque geometry have found that most plaques rupture at sites of high circumferential stress, thus diagnosis of plaque vulnerability may be enhanced by probing the mechanical behavior of individual plaques. Elastrography is a method of strain imaging in which an image sequence of the artery undergoing deformation is acquired, pixel ...
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    17. Methods and apparatus for characterizing lesions in blood vessels and other body lumens

      Methods, devices, and kits, for assessing luminal lesions are provided. The subject devices comprise an intraluminal detector capable of sensing radioactive or other labels. In the subject methods, a detectable marker is introduced to a body lumen, either into the lumen itself or systemically in patient circulation, and localizes at a lesion. The detector is introduced into the body lumen and the distribution of a localized marker detected in situ. The information is useful for a number of purposes including the identification of unstable plaque in patients suffering from atherosclerotic disease.
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    18. Method and apparatus for detecting vulnerable atherosclerotic plaque

      Methods and devices are disclosed for detecting vulnerable atherosclerotic plaque, or plaque at risk of reducing blood flow in a vessel, by a identifying a region of elevated temperature along a living vessel wall. The disclosure that human atherosclerotic plaque with measurable temperature heterogeneity has the morphological characteristics of plaque that is likely to ulcerate provides a new and sensitive technique for detecting and treating these dangerous plaques before myocardial infarction and its consequences occur. The disclosed methods are advantageous over conventional plaque detection techniques because they are capable of differentiating between those plaques that are at great risk of ...
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    19. Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation

      Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
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    20. Connection apparatus for optical coherence tomography catheters

      An optical catheter connection system is described which has two mating assemblies: a motor unit and an optical catheter connector. The optical catheter connector mates to the motor unit for coupling optical signal into and out of a catheter optical fiber and providing drive torque to the catheter optical fiber. The motor unit includes a rotary shaft powered by a motor for providing drive torque to the catheter optical fiber to rotate the fiber. The motor unit further includes a split sleeve for aligning a motor optical fiber with the catheter optical fiber for coupling optical signals between the two ...
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    21. Method of treatment of cardiovascular injuries

      The present invention provides a method for treating cardiovascular ailments. The method involves first screening an individual to determine their risk of having the potential for unstable plaques. Such individuals can be selected by looking at one of the following criteria: (i) increased plaque neovascularization, (ii) area ratio of intima to wall area of a plaque, (iii) evidence of plaque hemorrhage, or (iv) inflammatory cells associated with plaque vessels. Looking at these criteria permits one to select individuals having the potential for unstable plaques. The method then involves treating the selected individual with an effective amount of an angiogenesis inhibitor.
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    22. Electronically scanned optical coherence tomography with frequency modulated signals

      An improved Optical Coherence Domain Reflectometry (OCDR) system is provided. One embodiment of this OCDR system outputs a detector signal carrying image depth information on multiple modulation frequencies, where each modulation frequency corresponds to a different image depth. The image depth information from the detector signal may be resolved by tuning to the desired modulation frequency. Another system for imaging body tissue uses multiple frequency modulators such that the light beam does not travel from an optical fiber to free space.
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    3793-3816 of 3851 « 1 2 ... 156 157 158 159 160 161 »
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