1. Articles in category: Cardiology

    1-24 of 2345 1 2 3 4 ... 96 97 98 »
    1. Optical Coherence Tomography and Histopathology Assessment After Implantation of First- and Second-Generation Drug-Eluting Stents in a Porcine Coronary Model

      Optical Coherence Tomography and Histopathology Assessment After Implantation of First- and Second-Generation Drug-Eluting Stents in a Porcine Coronary Model

      Background: This study directly compared optical coherence tomography (OCT) and histopathology for the assessment of vascular response to first- and second-generation drug-eluting stents. Methods and Results: Sirolimus-, everolimus-, and biolimus-eluting stents (SES, EES, and BES, respectively) were randomly implanted into the coronary arteries of 12 porcine. OCT was conducted after implantation: at 1, 3, and 6 months; histopathology was assessed at 3 and 6 months. At 1-month OCT, EES had the highest neointimal area (NA) and lowest neointimal unevenness score (NUS). At 6 months, NA and NUS were equivalent among the stent types. ∆NA from 1 to 6 months was ...

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    2. New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient

      New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient

      A study using a relatively new imaging tool, optical coherence tomography (OCT), offered a new look at the composition of carotid artery disease and has the potential to alter how physicians understand and treat the disease, a leading cause of stroke. The study, conducted at Baptist Health Lexington between September 2010 and May 2012 , was featured in the June 2014 issue of the Journal of the American College of Cardiology (JACC) Cardiovascular Interventions. Interventional cardiologist Dr. Michael R. Jones served as a principal investigator of the study, which also included neurosurgeons Dr. William H. Brooks and Dr. Christian N. Ramsey ...

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    3. Glenn vs. The Volcano

      Glenn vs. The Volcano

      Today saw a "volley across the bow" between Volcano Corporation (Nasdaq: VOLC), a major manufacturer of IVUS, FFR and iFR technologies, and Engaged Capital LLC, an investment firm which holds over two million shares, or 5.1%, of Volcano stock. Engaged founder Glenn W. Welling sent a letter to Volcano demanding that the company begin a search for a new CEO and find a buyer for the company (press release printed below). The letter was prompted by the fact that Volcano's stock price has dropped by more than half over the past year. Engaged has been in discussions with ...

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    4. Infraredx Receives Regulatory Approval of TVC Imaging System in Japan

      Infraredx Receives Regulatory Approval of TVC Imaging System in Japan

      Infraredx, Inc., a medical device company committed to advancing the diagnosis and management of coronary artery disease, today announced that its first-in-class, dual-modality intravascular imaging technology, TVC Imaging System™, and its TVC Insight™ Catheter received Shonin approval from the Japanese Ministry of Health, Labour and Welfare (MHLW). The TVC System makes it possible to determine the structure and chemical composition of the coronary plaques that complicate stenting, and are associated with heart attacks. The TVC Imaging System console and catheter will be exclusively distributed by Goodman, a subsidiary of Osaka-based Nipro Corporation, which has extensive experience commercializing IVUS and other ...

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    5. Volcano Issues Statement Regarding Letter From Engaged Capital

      Volcano Issues Statement Regarding Letter From Engaged Capital

      Volcano Corporation (Nasdaq: VOLC), a leading company focused on improving patient and economic outcomes on a global basis by developing and delivering innovative minimally invasive coronary and peripheral visualization, physiology diagnostics and therapies, today confirmed receipt of a letter to its Board of Directors from Engaged Capital, LLC. The Company issued the following statement in response: Volcano welcomes the perspectives of its shareholders, and has a longstanding policy of open communications with all of our investors, includingEngaged Capital. The Company will carefully review and consider the ideas presented in the letter and continue its dialogue with Engaged Capital. The Volcano ...

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    6. Engaged Capital Sends Letter to the Board of Volcano Corporation

      Engaged Capital Sends Letter to the Board of Volcano Corporation

      Engaged Capital, an investment firm specializing in small and mid-cap North American equities and beneficial owner of approximately 2,638,403 shares of the common stock of Volcano Corporation (“VOLC” or the “Company”) (Nasdaq:VOLC), today sent an open letter http://engagedcapital.com/press/VOLCBODLetter.pdf to the Company’s Board of Directors (the “Board”), filed with the U.S. Securities and Exchange Commission. “It is time for new leadership. We urge the Board to immediately commence a parallel process to evaluate strategic alternatives and conduct a search for CEO candidates with a history of driving profitability and extracting value ...

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    7. Matching human pathology is essential for validating OCT imaging to detect high-risk plaques

      Matching human pathology is essential for validating OCT imaging to detect high-risk plaques

      We thank Mark Brezinski for his Correspondence ( Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques . Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.62-c1 ) 1 on our Review ( Clinical classification of plaque morphology in coronary disease . Nat. Rev. Cardiol. 11 , 379 – 389 ; 2014 ), 2 and for his comments and clarifications. We agree that the phenomenon

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    8. Venous Drug-Eluting vs. Bare-Metal Stenting: An Experimental Animal Study Using Frequency Domain Optical Coherence Tomography

      Venous Drug-Eluting vs. Bare-Metal Stenting: An Experimental Animal Study Using Frequency Domain Optical Coherence Tomography

      Introduction: This protocol was designed to evaluate the safety and feasibility of implanting drug-eluting stents (DES), as well as to compare their long-term results versus bare-metal stents (BMS), in a rabbit venous model, using frequency-domain optical coherence tomography (FD-OCT). Methods: Thirteen New Zealand white rabbits underwent implantation of a zotarolimus-eluting stent in the iliac vein (DES Group) and a BMS in the contralateral iliac vein (BMS Group). The study’s primary endpoints included technical success and the comparison of in-stent neointimal hyperplasia in the two study groups, using ex vivo FD-OCT, at 3 months. Results: Thirteen DES and 13 BMS ...

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    9. Atherosclerotic plaque characterization by CT angiography for identification of high-risk coronary artery lesions: a comparison to optical coherence tomography

      Atherosclerotic plaque characterization by CT angiography for identification of high-risk coronary artery lesions: a comparison to optical coherence tomography

      AIMS: Adverse plaque characteristics (APCs) by coronary computed tomography (CT) angiography (CTA) are associated with myocardial ischaemia and future acute coronary syndromes. The overall objective was to determine whether APCs on non-invasive CTA are associated with vulnerable plaque features by invasive optical coherence tomography (OCT). METHODS AND RESULTS: Sixty-eight coronary plaques in 45 patients were evaluated by CTA and OCT. APCs by CTA were: positive remodelling (PR), remodelling index ≥1.10; low attenuation plaque (LAP), any intraplaque voxel <30 Hounsfield units; spotty calcification (SC), intraplaque calcification ≤3 mm; and 'napkin-ring' sign, low intraplaque attenuation surrounded by a higher attenuation rim ...

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    10. Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Serious concerns exist about the Review by Otsuka et al . (Clinical classification of plaque morphology in coronary disease. Nat. Rev. Cardiol. 11, 379–389; 2014 ), 1 some of which are discussed in this Correspondence. The concerns are predominately about the authors' understanding of the principles and application of optical coherence tomography (OCT),

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    11. One-Year Follow-Up Optical Coherence Tomography After Implantation of Bioresorbable Vascular Scaffolds for a Chronic Coronary Total Occlusion

      One-Year Follow-Up Optical Coherence Tomography After Implantation of Bioresorbable Vascular Scaffolds for a Chronic Coronary Total Occlusion

      A 70-year-old male underwent coronary angiography because of worsening angina, which demonstrated proximal left anterior descending coronary artery (LAD) chronic total occlusion (CTO) collateralized by septal branches from the right coronary and antegrade bridge (Figure 1A).

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    12. Tissue characterization of progressive cardiac allograft vasculopathy in patients with everolimus therapy compared with donor-transmitted atherosclerosis assessed using serial intravascular imaging: a case report

      Tissue characterization of progressive cardiac allograft vasculopathy in patients with everolimus therapy compared with donor-transmitted atherosclerosis assessed using serial intravascular imaging: a case report

      Using serial intravascular ultrasound (IVUS), integrated-backscatter IVUS, and optical coherence tomography, we observed rapidly progressive cardiac allograft vasculopathy (CAV) and donor-transmitted plaque in the left anterior descending artery. Late-phase everolimus-resistant CAV had a rapidly progressive course (maximal intimal thickness [MIT] increased by 0.5 mm between years 3 and 4 after cardiac transplantation, from MIT growth <0.5 mm at year 1). Conversely, the donor-transmitted plaque grew slowly (0.1 mm increase during the same period). Tissue characteristics in the 2 segments were also different; CAV had eccentric, noncalcified, and lipid-rich components and was associated with macrophage accumulation, whereas donor-transmitted ...

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    13. Feasibility and repeatability of optical coherence tomography measurements of pre-stent thrombus burden in patients with STEMI treated with primary PCI

      Feasibility and repeatability of optical coherence tomography measurements of pre-stent thrombus burden in patients with STEMI treated with primary PCI

      AIMS: Intracoronary thrombus is disrupted by stent deployment and confounded by the development of intrastent plaque prolapse. This study aims at investigating the feasibility and repeatability of thrombus quantification prior to stent implantation using optical coherence tomography (OCT) in ST-segment elevation myocardial infarction (STEMI) patients. METHODS AND RESULTS: Patients were enrolled in an OCT substudy of the TOTAL trial (a randomized trial of routine aspiration ThrOmbecTomy with PCI vs. PCI ALone in patients with STEMI undergoing primary PCI) of aspiration thrombectomy or percutaneous coronary intervention (PCI) alone in primary PCI (PPCI) of STEMI. Using OCT, thrombus burden (TB) and other ...

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    14. Morphological features of non-culprit plaques on optical coherence tomography and integrated backscatter intravascular ultrasound in patients with acute coronary syndromes

      Morphological features of non-culprit plaques on optical coherence tomography and integrated backscatter intravascular ultrasound in patients with acute coronary syndromes

      Aims We sought to compare the morphological features of non-culprit plaques with >50% diameter stenosis in patients with acute coronary syndromes (ACS) with those of culprit plaques in patients with ACS and stable ang in a pectoris (SAP) us in g optical coherence tomography (OCT) and integrated backscatter intravascular ultrasound (IB-IVUS). Methods and results A total of 150 culprit and non-culprit coronary plaques ( non-culprit vessels) in 150 patients with coronary artery disease were in terrogated by OCT before percutaneous coronary in terventi on (PCI). Patients were categorized as follows: 73 culprit plaques in patients with ACS (ACS-C), 32 non-culprit plaques ...

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    15. Coronary Endothelial Dysfunction Is Associated With Inflammation and Vasa Vasorum Proliferation in Patients With Early Atherosclerosis

      Coronary Endothelial Dysfunction Is Associated With Inflammation and Vasa Vasorum Proliferation in Patients With Early Atherosclerosis

      Objective— Endothelial dysfunction is an early manifestation of atherosclerosis . Inflammation and vasa vasorum play a pivotal role in the pathophysiology of plaque in itiation, development, and complications. Optical coherence tomography allows high-resolution imag in g of t is sue microstructure. Therefore, the aim of th is study was to test the hypothes is that segments with endothelial dysfunction show macrophages and vasa vasorum in patients with early coronary artery d is ease. Approach and Results— Optical coherence tomography images were obta in ed from 40 patients with mild coronary atherosclerosis who underwent coronary endothelial function assessment. Optical coherence tomography f ...

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    16. A novel method to assess coronary artery bifurcations by OCT: cut-plane analysis for side-branch ostial assessment from a main-vessel pullback

      A novel method to assess coronary artery bifurcations by OCT: cut-plane analysis for side-branch ostial assessment from a main-vessel pullback

      Aims In coronary bifurcations assessment, evaluation of side-branch (SB) ostia by an optical coherence tomography (OCT) pullback performed in the main branch (MB) could speed up lesion evaluation and minimize contrast volume. Dedicated software that reconstructs the cross-sections perpendicular to the SB centreline could improve this assessment. We aimed to validate a new method for assessing the SB ostium from an OCT pullback performed in the MB. Methods and results Thirty-one sets of frequency-domain OCT pullbacks from 28 patients, both from the MB and the SB of a coronary artery bifurcation were analysed. Measurements of the SB ostium from the ...

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    17. Latest Data Shows OrbusNeich's COMBO™ Dual Therapy Stent has Excellent

      Latest Data Shows OrbusNeich's COMBO™ Dual Therapy Stent has Excellent

      Prof. Stephen W.L. Lee presented two-year optical coherence tomography (OCT) findings and three-year clinical follow up from the EGO COMBO study, providing further evidence to support the healing benefits of the COMBO Dual Therapy Stent, the only drug eluting stent (DES) with active EPC capture technology. The findings were presented during the 26th Annual Transcatheter Cardiovascular Therapeutics (TCT) meeting, held in Washington, D.C. , September 13-17, 2014 . "This is the first study to assess the healing profile of a dual therapy stent by optical coherence tomography," said Prof. Stephen W.L. Lee , M.D., of the Queen Mary Hospital ...

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    18. New Study Assesses the Utility of Optical Coherence Tomography During Stent Implantation in Primary PCI

      New Study Assesses the Utility of Optical Coherence Tomography During Stent Implantation in Primary PCI

      The first randomized trial to examine serial optical coherence tomography (OCT) in primary percutaneous coronary intervention (PCI) was reported today at the 26 th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. OCT uses light emitted from an intravascular catheter to capture high-resolution cross sectional imaging from within coronary arteries. OCT STEMI is the first randomized multicenter study to examine routine use of OCT guidance during stent implantation in patients with ST-elevation myocardial infarction (STEMI, the most serious form of a ...

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    19. Causes of very late stent thrombosis investigated using optical coherence tomograph

      Causes of very late stent thrombosis investigated using optical coherence tomograph

      Objective Very late stent thrombosis (VLST) remains an unresolved problem, and recent reports have indicated that VLST onset can occur in patients treated with both drug-eluting stents (DES) and bare metal stents (BMS). We evaluated the causes of VLST using optical coherence tomography (OCT). Methods OCT was performed in 22 patients (12 DES-treated patients, 10 BMS-treated patients). Because two instances of VLST occurred simultaneously in one case in the DES group, the DES group comprised 13 lesions, while the BMS group comprised 10 lesions. All struts were counted in each frame, and the proportion of uncovered or malapposed struts was ...

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    20. St. Jude Medical Announces Launch of OPTIS Integrated System

      St. Jude Medical Announces Launch of OPTIS Integrated System

      The OPTIS™ Integrated System combines OCT imaging with angiography to provide more detailed, on-demand coronary assessment for more accurate PCI guidanc e St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the company has secured CE Mark and FDA clearance for the new OPTIS Integrated System. The system is a departure from traditional, mobile cart-based diagnostic tools and advances percutaneous coronary intervention (PCI) optimization via direct installation into a hospital’s cardiac catheterization laboratory, fully integrating optical coherence tomography (OCT) and fractional flow reserve (FFR) into PCI workflow. The approval of the OPTIS Integrated system marks ...

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    21. OCT STEMI: Optical Coherence Tomography Guidance During Primary PCI in AMI

      OCT STEMI: Optical Coherence Tomography Guidance During Primary PCI in AMI

      The OCT STEMI trial presented Sept. 14 at TCT 2014 looked at optical coherence tomography (OCT) guidance during drug-eluting stent implantation in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), and was the first randomized trial to look at serial OCT in primary PCI, but ultimately showed that larger randomized trials are needed on this topic to assess potential benefit. Led by principal investigator Pavel Červinka, MD, PhD, First Department of Cardio-Angiology and Internal Medicine, Faculty Hospital Hradec Králové, Czech Republic, the trial enrolled 201 patients, who were pre-treated with aspirin, heparin and ...

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    22. Automatic detection of bioresorbable vascular scaffold struts in intravascular optical coherence tomography pullback runs

      Automatic detection of bioresorbable vascular scaffold struts in intravascular optical coherence tomography pullback runs

      Bioresorbable vascular scaffolds (BVS) have gained significant interest in both the technical and clinical communities as a possible alternative to metallic stents. For accurate BVS analysis, intravascular optical coherence tomography (IVOCT) is currently the most suitable imaging technique due to its high resolution and the translucency of polymeric BVS struts for near infrared light. However, given the large number of struts in an IVOCT pullback run, quantitative analysis is only feasible when struts are detected automatically. In this paper, we present an automated method to detect and measure BVS struts based on their black cores in IVOCT images. Validated using ...

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    1-24 of 2345 1 2 3 4 ... 96 97 98 »
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