1. Articles in category: Cardiology

    1-24 of 3291 1 2 3 4 ... 136 137 138 »
    1. Avinger’s Pantheris Named a 2017 Gold Edison Award Winner

      Avinger’s Pantheris Named a 2017 Gold Edison Award Winner

      Avinger, Inc., a leading developer of innovative treatments for peripheral artery disease (PAD), was honored at the 2017 Edison Awards™ in the Medical/Dental Surgical Tool category with gold for Pantheris, the first-ever image-guided atherectomy device for the treatment of PAD. Avinger was nominated among hundreds of the world’s most recognized companies to acknowledge dedication and commitment of innovation to create a positive impact in the world. The ballot of nominees for the Edison Awards was judged by a panel of more than 3,000 leading business executives including past award winners, academics and leaders in the fields of ...

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    2. Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52). Fibrous cap thickness (FCT) was measured at its thinnest part 3 times ...

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    3. Optical coherence tomography-guided PCI

      Optical coherence tomography-guided PCI

      I read with great interest the results of the ILUMIEN III trial by Ziad Ali and colleagues (Nov 26, p 2618–28), 1 which did not show superiority for optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) compared with angiography-guided PCI. No difference was found in the primary endpoint—minimum stent area after PCI—between the two strategies (p=0·12). Although guidance by OCT resulted in fewer untreated dissections than did guidance by angiography (39 vs 61, p=0·006), this difference was driven by an increase in the number of minor dissections in the angiography group compared ...

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    4. Optical coherence tomography-guided PCI – Authors' reply

      Optical coherence tomography-guided PCI – Authors' reply

      We read with interest the Correspondence by Rahman Shah regarding our 2016 ILUMIEN III: OPTIMIZE PCI trial. 1 In nearly all previous studies of percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) or optical coherence tomography (OCT), the most important predictor of follow-up events was the minimum stent area, followed by edge dissections and untreated disease. 2 , 3 Nine randomised trials 4 have compared IVUS guidance versus angiography guidance for PCI with drug-eluting stents (DES). IVUS guidance improved event-free survival by achieving larger acute stent dimensions than angiography guidance. 4 Therefore, before embarking on a definitive trial comparing OCT-guided ...

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    5. Post-dilatation after implantation of bioresorbable everolimus- and novolimus-eluting scaffolds: an observational optical coherence tomography study of acute mechanical effects

      Post-dilatation after implantation of bioresorbable everolimus- and novolimus-eluting scaffolds: an observational optical coherence tomography study of acute mechanical effects

      bjectives The objective was to investigate the acute mechanical effects of post-dilatation on bioresorbable scaffolds (BRS) as determined by optical coherence tomography (OCT). Background Post-dilatation with high-pressure balloons is regarded as a key component of BRS implantation for treatment of coronary artery stenoses. However, the impact of post-dilatation on BRS in vivo has not been thoroughly investigated. Methods OCT was performed after the implantation procedure of 51 everolimus-eluting or novolimus-eluting polylactic acid-based BRS with ( n = 27) or without non-compliant balloon post-dilatation ( n = 24). The number of malapposed struts, strut fractures, edge dissections, residual in-scaffold area stenosis, and incomplete scaffold apposition ...

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    6. Characteristics of Earlier Versus Delayed Presentation of Very Late Drug‐Eluting Stent Thrombosis: An Optical Coherence Tomographic Study

      Characteristics of Earlier Versus Delayed Presentation of Very Late Drug‐Eluting Stent Thrombosis: An Optical Coherence Tomographic Study

      Background The pathophysiology underlying very late drug‐eluting stent ( DES ) thrombosis is not sufficiently understood. Using optical coherence tomography, we investigated characteristics of very late stent thrombosis ( VLST ) according to different onset times. Methods and Results A total of 98 patients from 10 South Korean hospitals who underwent optical coherence tomography for evaluation of very late DES thrombosis were retrospectively included in analyses. VLST occurred at a median of 55.1 months after DES implantation. All patients were divided into 2 equal groups of earlier versus delayed presentation of VLST , according to median onset time. In total, 27 patients were ...

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    7. Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart

      Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart

      Efficient separation of blood and cardiac wall in the beating embryonic heart is essential and critical for experiment-based computational modelling and analysis of early-stage cardiac biomechanics. Although speckle variance optical coherence tomography (SV-OCT) relying on calculation of intensity variance over consecutively acquired frames is a powerful approach for segmentation of fluid flow from static tissue, application of this method in the beating embryonic heart remains challenging because moving structures generate SV signal indistinguishable from the blood. Here, we demonstrate a modified four-dimensional SV-OCT approach that effectively separates the blood flow from the dynamic heart wall in the beating mouse embryonic ...

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    8. Lower Extremity Revascularization Using Optical Coherence Tomography–Guided Directional Atherectomy: Final Results of the EValuatIon of the PantheriS OptIcal COherence Tomography ImagiNg Atherectomy System for Use in the Peripheral Vasculature (VISION) St

      Lower Extremity Revascularization Using Optical Coherence Tomography–Guided Directional Atherectomy: Final Results of the EValuatIon of the PantheriS OptIcal COherence Tomography ImagiNg Atherectomy System for Use in the Peripheral Vasculature (VISION) St

      Purpose: To evaluate the safety and efficacy of a novel optical coherence tomography (OCT)–guided atherectomy catheter in treating patients with symptomatic femoropopliteal disease. Methods: The VISION trial ( ClinicalTrials.gov identifier NCT01937351) was a single-arm, multicenter, global investigational device exemption study enrolling 158 subjects (mean age 67.2±10.5 years; 87 men) across 20 participating sites. In this cohort, 198 lesions were treated with an average length of 53±40 mm using the Pantheris catheter alone or Pantheris + adjunctive therapy. The primary safety endpoint was the composite of major adverse events (MAEs) through 6 months (objective performance goal 43 ...

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    9. Optical coherence tomography: guided therapy of instent restenosis for Peripheral Arterial Disease

      Optical coherence tomography: guided therapy of instent restenosis for Peripheral Arterial Disease

      Approximately 27 million people in Europe and North America currently have peripheral arterial disease (PAD)1. The endovascular treatment of stenosis or blocked peripheral arteries in PAD include percutaneous transluminal angioplasty (PTA) with or without a drug coated balloon, atherectomy (rotational, directional, orbital or laser), and stenting. The development of next generation peripheral stents and drug coated stents have led to the improved treatment of complex SFA lesions, and consequently increased their usage23. Additionally, the technologies developed for PAD intervention have further improved the overall adoption of endovascular procedures leading to increased utilization of stents to address procedural dissections (bail-out ...

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    10. UC Irvine Receives at NIH for Combined OCT/US/PAT System for Intravascular Imaging

      UC Irvine Receives at  NIH for Combined OCT/US/PAT System for Intravascular Imaging

      University of California at Irvine Received at 2017 NIH Grant for $686,184 for Combined OCT/US/PAT System for Intravascular Imaging. The principal investigator is Zhongping Chen. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, cholesterol, fibrous constituents, monocytes, and various other inflammatory cells in the arterial wall. Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. The major cause of deaths from heart attacks (86%) and brain aneurysm (45%) are due ...

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    11. Optical coherence tomography for strategy planning and staged optimization of spontaneous coronary artery dissection

      Optical coherence tomography for strategy planning and staged optimization of spontaneous coronary artery dissection

      A 49-year-old non-pregnant female, taking no hormonal replacement therapy, smoker, and with a family history of myocardial infarction, was admitted with inferior ST-segment elevation myocardial infarction. Angiography of the right coronary artery demonstrated a diffuse tubular narrowing in the proximal segment ( A ). A spontaneous coronary artery dissection (SCAD), type 2A, was suspected. Optical coherence tomography (OCT) demonstrated a large dissection, with the presence of a false double lumen and an associated diffuse circular haematoma, resulting in the compression of the true lumen ( B – C – D ). Because of ongoing ischaemia (ST-elevation and severe chest pain), the decision to stent the dissection ...

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    12. Avinger to lay off a third of workforce

      Avinger to lay off a third of workforce

      Avinger said yesterday that it plans to lay off a third of its workforce and examine its “strategic alternatives” as it focuses on its Pantheris peripheral artery device. The layoffs, affecting 131 workers, are slated to be complete this week, the Redwood City, Calif.-based company said, including cutting its field sales force by nearly half, from 60 to 32. “The plan is designed to focus the company’s commercial efforts on driving catheter utilization in its strongest markets, around its most productive sales professionals,” Avinger said. “This workforce reduction is designed to reduce operating expenses while continuing to support ...

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      Mentions: Avinger
    13. You can’t judge a book by its cover: a trivial angiographic image, an optical coherence tomography run and a surprising ending

      You can’t judge a book by its cover: a trivial angiographic image, an optical coherence tomography run and a surprising ending

      A 75 year-old man was hospitalized for recent onset of low-threshold effort dyspnoea and moderate reduction of the left ventricular ejection fraction (39%, 2 weeks before it measured 55%) with infero-postero-lateral ipokinesia and severe mitral regurgitation. His medical history included three-vessel coronary artery disease treated by percutaneous coronary intervention (PCI) and implantation of drug eluting stents (DES) on the mid left anterior descending coronary artery, the mid left circumflex coronary artery and the distal right coronary artery (RCA).

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    14. Polarization image segmentation of radiofrequency ablated porcine myocardial tissue

      Polarization image segmentation of radiofrequency ablated porcine myocardial tissue

      Optical polarimetry has previously imaged the spatial extent of a typical radiofrequency ablated (RFA) lesion in myocardial tissue, exhibiting significantly lower total depolarization at the necrotic core compared to healthy tissue, and intermediate values at the RFA rim region. Here, total depolarization in ablated myocardium was used to segment the total depolarization image into three (core, rim and healthy) zones. A local fuzzy thresholding algorithm was used for this multi-region segmentation, and then compared with a ground truth segmentation obtained from manual demarcation of RFA core and rim regions on the histopathology image. Quantitative comparison of the algorithm segmentation results ...

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    15. Optical coherence tomography evaluation of tissue prolapse after carotid artery stenting using closed cell design stents for unstable plaque

      Optical coherence tomography evaluation of tissue prolapse after carotid artery stenting using closed cell design stents for unstable plaque

      Background and purpose During carotid artery stenting (CAS) with the use of closed cell design stents for unstable plaques, tissue prolapse between stent struts was evaluated by optical coherence tomography (OCT). Methods 14 carotid stenosis lesions diagnosed as unstable plaques by MRI were evaluated by OCT imaging during CAS using closed cell stents. Cross sectional OCT images within the stented segment were evaluated at 1 mm intervals. The slice rate for the presence of tissue prolapse between the struts was calculated. Results No intra-procedural complications occurred. After single stent placement, plaque prolapse was observed in all cases. Slices with any ...

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    16. Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      An estimated 17.5 million people died from a cardiovascular disease in 2012, representing 31 percent of all global deaths. Most acute coronary events result from rupture of the protective fibrous cap overlying an atherosclerotic plaque. The task of early identification of plaque types that can potentially rupture is, therefore, of great importance. The state-of-the-art approach to imaging blood vessels is intravascular optical coherence tomography (IVOCT). However, currently, this is an offline approach where the images are first collected and then manually analyzed an image at a time to identify regions at risk of thrombosis. This process is extremely laborious ...

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    17. Approaches to segment stent area from Intravascular Optical Coherence Tomography

      Approaches to segment stent area from Intravascular Optical Coherence Tomography

      Introduction Cardiovascular diseases (CVD) have been the focus of research in recent years due to its high mortality rate. It is estimated that 17.5 million people died of CVD in 2012, from which 7.4 million were due to coronary heart disease (CHD). In order to monitor CHD patients and avoid waste of specialists' time, this study proposes the development of a method that segments the area contained by stent struts from Frequency Domain Intravascular Optical Coherence Tomography (the latest technology to view vessels internally) of coronary arteries. Methods The novelty of this study is to find areas comprised ...

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    18. The role of residual intrastent thrombus during primary angioplasty: insights from the COCTAIL II study

      The role of residual intrastent thrombus during primary angioplasty: insights from the COCTAIL II study

      Aims: Recent frequency-domain optical coherence tomography studies showed that a complete removal of thrombotic materials is rarely achieved after percutaneous coronary interventions for ST segment elevation myocardial infarction. Residual intrastent thrombus can embolize distally leading to microcirculatory injury. The aim was to find a possible correlation between residual intrastent thrombus and angiographic indexes of myocardial reperfusion. Methods: The population consisted of 128 ST segment elevation myocardial infarction patients enrolled in the COCTAIL II trial. Intrastent thrombus at optical coherence tomography was defined as the maximum percentage value of thrombus area (thrombus area/stent area × 100 in the cross-section with largest ...

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      Mentions: Francesco Prati
    1-24 of 3291 1 2 3 4 ... 136 137 138 »
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