1. Category: Cardiology

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    1. Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters

      Explore eurointervention.org (May 16 2012)

      Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters

      Aims: The aim of this study was to assess the ability of optical coherence tomography (OCT) to guide recrossing during percutaneous coronary interventions in bifurcations and to reduce strut malapposition.


      Comment Mentions:   Imperial College London   Carlo Di Mario   Royal Brompton Hospital

    2. Coronary artery perforation imaged through 3-dimensional optical coherence tomography

      Explore eurointervention.org (May 16 2012)

      Coronary artery perforation imaged through 3-dimensional optical coherence tomography

      A 54-year-old man with non-ST elevation myocardial infarction (NSTEMI) underwent percutaneous coronary intervention (PCI) for a severe stenosis in the first marginal branch of the left circumflex coronary artery (LCx-OM1) (Figure 1).


      Comment Mentions:   Terumo Cardiovascular Systems   Francesco Prati

    3. Offline fusion of co-registered intravascular ultrasound and frequency domain optical coherence tomography images for the analysis of human atherosclerotic plaques

      Explore eurointervention.org (May 16 2012)

      Offline fusion of co-registered intravascular ultrasound and frequency domain optical coherence tomography images for the analysis of human atherosclerotic plaques

      Aims: To demonstrate the feasibility and potential usefulness of an offline fusion of matched optical coherence tomography (OCT) and intravascular ultrasound (IVUS)/virtual histology (IVUS-VH) images.


      Comment Mentions:   Patrick W. Serruys   Hector M. Garcia-Garcia   University of Bern

    4. The Clinical Atlas of Intravascular Optical Coherence Tomography iPad Application (Book)

      Explore Optical Coherence Tomography News (May 11 2012)

      The Clinical Atlas of Intravascular Optical Coherence Tomography iPad Application (Book)

      Developed specifically for the iPad, The Clinical Atlas of OCT offers a rapid and interactive guidance to a systematic and scientifically critical interpretation of OCT images for interventional cardiologists, pathologists, and other physicians, technicians, trainees and research staff.  See screenshots by clicking HERE. Led by Professor Patrick W. Serruys, Dr. Maria Radu, Dr. Lorenz Räber and Dr. Hector Garcia-Garcia, the team behind this publication includes several international well-renowned experts and key opinion leaders within the field of intracoronary imaging and pathology. The Clinical Atlas of Intravascular OCT comprises eight separate chapters offering the following contents: 1. Principles of OCT 2 ...


      Comment Mentions:   Patrick W. Serruys   Hector M. Garcia-Garcia   Erasmus Medical Center

    5. Circulating malondialdehyde-modified low-density lipoprotein levels are associated with the presence of thin-cap fibroatheromas determined by optical coherence tomography in coronary artery disease

      Explore ehjcimaging.oxfordjournals.org (May 11 2012)

      Circulating malondialdehyde-modified low-density lipoprotein levels are associated with the presence of thin-cap fibroatheromas determined by optical coherence tomography in coronary artery disease

      Aims The importance of oxidized low-density lipoprotein (oxLDL) has been implicated in the process of plaque rupture. However, few previous studies demonstrated the relationship between plaque morphology and oxLDL. We evaluated the relationship between coronary plaque vulnerability assessed by optical coherence tomography (OCT) and circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL). Methods and results OCT was used to determine plaque vulnerability in 102 patients with acute coronary syndrome (ACS; n = 53) and stable angina pectoris (SAP; n = 49). Circulating levels of MDA-LDL were measured by using enzyme-linked immunosorbent assay. Thin-cap fibroatheromas (TCFAs; defined as lipid-rich with plaque cap thickness


      Comment Mentions:   Wakayama Medical University   Takashi Kubo   Takashi Tanimoto

    6. Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Explore Wiley Online Library (May 9 2012)

      Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Objective To demonstrate the feasibility of imaging human coronary atherosclerosis using a novel hybrid intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging catheter. Background IVUS and OCT have synergistic advantages and recent studies involving both modalities suggest the use of a hybrid imaging catheter may offer improved guidance of coronary interventions and plaque characterization. Methods A 1.3 m custom hybrid IVUS-OCT imaging probe was built within a 4F catheter using a 42 MHz ultrasound transducer and an OCT imaging fiber. Coplanar images were simultaneously acquired ex vivo by both modalities in 31 arterial segments from 11 cadaveric human ...


      Comment Mentions:   Sunnybrook Health Sciences Centre   Victor X. D. Yang   Nigel R. Munce

    7. INtimal hyPerplasia evAluated by oCT in de novo COROnary lesions treated by drug-eluting balloon and bare-metal stent (IN-PACT CORO): study protocol for a randomized controlled trial

      Explore Trials (May 9 2012)

      INtimal hyPerplasia evAluated by oCT in de novo COROnary lesions treated by drug-eluting balloon and bare-metal stent (IN-PACT CORO): study protocol for a randomized controlled trial

      Background Neointimal hyperplasia plays a pivotal role in the pathogenesis of in-stent restenosis in patients undergoing percutaneous coronary interventions. Drug-eluting balloons are a promising tool to prevent restenosis after coronary angioplasty. Moreover, an increased knowledge of the pathophysiology of restenosis my help improve therapeutic strategies. Methods We present the design of an open-label, randomized three-arm clinical trial aimed to assess whether a strategy of bare-metal stent implantation with additional use of drug-eluting balloons, either before (pre-dilation) or after stenting (post-dilation), reduces the primary endpoint of in-stent neointimal hyperplasia area as compared with a strategy of bare-metal stent implantation alone. This ...


      Comment Mentions:   Lightlab C7 XR OCT Imaging System   St. Jude Medical

    8. Massachusetts General Hospital wins NIH Grant to on Development of a Preclinical Optical Frequency Domain Angiography Instrument

      Explore Optical Coherence Tomography News (May 8 2012)

      Massachusetts General Hospital wins NIH Grant to on Development of a Preclinical Optical Frequency Domain Angiography Instrument

      The Massachusetts General Hospital received a $464,845 2012 NIH grant to develop a preclinical optical frequency domain angiography instrument. The principal Investigator is Benjamin Vakoc. This grant is part of a multi-year project that started in 2012 and ends in 2017. Below is a summary of the work. Tumor-induced angiogenesis plays a central role in the progression of tumors to malignancy, provides the critical transport of blood-born therapies into the tumor space, and supplies oxygen to effectuate oxygen-dependent radiological and light-based therapies. Pre-clinical research in tumor angiogenesis and tumor microvascular function has traditionally relied on histological methods, which suffer ...


      Comment Mentions:   Massachusetts General Hospital   Harvard University   Benjamin J. Vakoc

    9. Methods and devices for image-guided manipulation or sensing or anatomic structures

      Explore uspto.gov (May 8 2012)

      Methods and devices for image-guided manipulation or sensing or anatomic structures

      Forward-looking ultrasound transducers are positioned at the tip of a transseptal catheter to facilitate transseptal puncture and interventions within the left atrium, pulmonary veins and mitral valve. Catheter devices and systems are guided by forward-looking ultrasound or optical coherence tomography imaging for penetrating from one location within a mammalian patient's body to another location, and/or performing diagnostic or therapeutic interventions. A penetrator, diagnostic, or interventional device (eg. probe, biopsy apparatus, electrode, needle) is positioned at the catheter tip and is advanceable from the catheter to a target location outside of the lumen in which the catheter is positioned ...


      Comment Mentions:   University of Toronto   Sunnybrook Health Sciences Centre   Brian K. Courtney

    10. Intracoronary Stenting and Angiographic Results: ORSIRO Stents Versus Xience PRIME Stents Assessed by Optical Coherence Tomography

      Explore ClinicalTrials.gov (May 7 2012)

      Intracoronary Stenting and Angiographic Results: ORSIRO Stents Versus Xience PRIME Stents Assessed by Optical Coherence Tomography

      This prospective, randomized trial will compare the extent of covered stent strut segments by assessed by Optical Coherence Tomography (OCT) of the ORSIRO DES with that of the XIENCE PRIME DES, which is the standard of choice of contemporary drug eluting stents (DES).


      Comment

    11. Volcano Corporation Presentation At JMP Securities Conference To Be Webcast

      Explore Volcano Corporation (May 7 2012)

      Volcano Corporation Presentation At JMP Securities Conference To Be Webcast

      Volcano Corporation (NASDAQ: VOLC), a leading developer and manufacturer of precision guided therapy tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, said today that it will be participating in the 11th Annual JMP Securities Research Conference on Monday, May 14.The presentation by John Dahldorf, chief financial officer, will begin at 10:30 a.m., Pacific Daylight Time (1:30 p.m., Eastern Daylight Time). The presentation will be available through the conference website at http://www.wsw.com/webcast/jmp17/volc/ and via the company's website at www.volcanocorp.com. Volcano Corporationis ...


      Comment Mentions:   Volcano Corporation   John Dahldorf

    12. Optical Coherence Tomography Imaging: Novel Insights into the Vascular Response After Coronary Stent Implantation

      Explore SpringerLink Home (May 5 2012)

      Optical Coherence Tomography Imaging: Novel Insights into the Vascular Response After Coronary Stent Implantation

      Optical coherence tomography (OCT) is a high-resolution imaging technique that is increasingly used for intracoronary imaging to characterize coronary atherosclerotic plaques and vascular responses after coronary stent implantation. Introduction of optical frequency-domain imaging (OFDI; second generation OCT) has simplified practical use of this novel imaging modality resulting in a more widespread availability in interventional cardiology. Here we highlight recent insights into the acute and chronic vascular response after coronary stent implantation by OCT imaging. OCT provides cross-sectional images with approximately 10-fold higher resolution as compared to intravascular-ultrasound (IVUS), allowing for precise evaluation of tissue coverage and malapposition of coronary stent ...


      Comment

    13. Optical Coherence Tomography: Potential Clinical Applications

      Explore SpringerLink Home (May 3 2012)

      Optical Coherence Tomography: Potential Clinical Applications

      Abstract  Optical coherence tomography (OCT) is a novel intravascular imaging modality using near-infrared light. By OCT it is possible to obtain high-resolution cross-sectional images of the vascular wall structure and assess the acute and long-term effects of percutaneous coronary intervention. For the time being OCT has been mainly used in research providing new insights into the pathophysiology of the atheromatic plaque and of the vascular response to stenting, however, it seems that there is potential for clinical application of OCT in various fields, such as pre-interventional evaluation of coronary arteries, procedural guidance in coronary interventions, and follow-up assessment of vascular ...


      Comment Mentions:   Evelyn Regar   Erasmus Medical Center   Gijs van Soest

    14. OCT in Coronary Bifurcations (Book Chapter)

      Explore Wiley Online Library (May 3 2012)

      OCT in Coronary Bifurcations (Book Chapter)

      The geometric and anatomical complexity of bifurcations makes its systematic scientific approach very challenging. Optical coherence tomography (OCT) is able to depict accurately the plaque distribution around the bifurcation, to provide valuable information to tailor the procedure in each specific case, and to assess the result after stenting. Some guidelines are proposed for the systematic study of bifurcations with OCT, assessing the apposition, tissue coverage, the presence of overlap or multi-layer segments, the presence of non-apposed side-branch struts, the scaffolding of the carina and the shoulder, and the access to the side branch.


      Comment Mentions:   Patrick W. Serruys   Evelyn Regar   Erasmus Medical Center

    15. Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging

      Explore Linking to Scitation Content (May 3 2012)

      Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging

      Carotid angioplasty and stenting is a minimally invasive endovascular procedure that may benefit from in vivo high resolution imaging for monitoring the physical placement of the stent and potential complications. The purpose of this pilot study was to evaluate the ability of optical coherence tomography to construct high resolution 2D and 3D images of stenting in porcine carotid artery. Four Yorkshire pigs were anaesthetized and catheterized. A state-of-the-art optical coherence tomography (OCT) system and an automated injector were used to obtain both healthy and stented porcine carotid artery images. Data obtained were then processed for visualization. The state-of-the-art OCT system ...


      Comment Mentions:   University of Toronto   Sunnybrook Health Sciences Centre   Victor X. D. Yang

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