1. Articles in category: Cardiology

    1-24 of 4225 1 2 3 4 ... 174 175 176 »
    1. A case report of a recurrent early and late Bioresorbable vascular scaffold thrombosis: serial angiography and optical coherence tomography findings

      A case report of a recurrent early and late Bioresorbable vascular scaffold thrombosis: serial angiography and optical coherence tomography findings

      Background In bioresorbable vascular scaffolds (BVSs), there is some concern about a possible increase in the rate of scaffold thromboses (ScTs). Although several characteristics similarly contribute to the development of both early and late ScTs, there are also clearly different pathomechanisms between the two time-dependent types of thromboses, especially with BVSs. Case presentation We recently experienced a very rare case of a 69-year-old man who had recurrent early and late ScTs with somewhat differing pathomechanisms as assessed by optical coherence tomography (OCT). For the late ScT, OCT identified a scaffold dismantling in the same place that a peri-strut low intensity ...

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    2. Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomography

      Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomography

      Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explore the associations between Cer and culprit plaque characterizations evaluated by optical coherence tomography (OCT). It was found that plasma Cer are associated with culprit plaque vulnerability evaluated by OCT, providing evidence supporting proatherogenic roles and potential to act as markers for plaque vulnerability of Cer.

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    3. Randomized comparison of optical coherence tomography versus angiography to guide Bioresorbable vascular scaffold implantation: The OPTICO BVS stud

      Randomized comparison of optical coherence tomography versus angiography to guide Bioresorbable vascular scaffold implantation: The OPTICO BVS stud

      Purpose We investigated whether optical coherence tomography (OCT)-guided bioresorbable vascular scaffolds (BVS) implantation can improve in-scaffold minimal lumen area (MLA) at 6-month compared with angiography guidance. Methods The OPTICO BVS was a randomized, international multicenter, assessor blind, superiority trial comparing OCT- versus angiography-guided percutaneous coronary intervention (PCI) (1:1 allocation) in patients with coronary artery disease undergoing Absorb BVS 1.1 implantation. The primary endpoint was in-scaffold MLA at 6-month. Results The trial was prematurely stopped on May 31, 2017 after enrollment of 38 of 270 planned patients (14%) following the retraction of the device in Europe. Patients were ...

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    4. Novel volumetric analysis for stent expansion after drug‐eluting stent implantation: An optical coherence tomography study

      Novel volumetric analysis for stent expansion after drug‐eluting stent implantation: An optical coherence tomography study

      Objectives To assess the clinical significance of a novel optical coherence tomography (OCT)‐derived volumetric parameter of stent expansion by comparing it with the conventional parameters in real‐world practice. Background The clinical significance of novel parameters in real‐world practice including longer and smaller stents remains to be elucidated. Methods A total of 226 de novo lesion treated with drug‐eluting stents in 208 consecutive patients were enrolled. Stent expansion was retrospectively assessed on the final OCT images after stent implantation. The novel parameter was the minimum expansion index (MEI) calculated using a novel algorithm that yields the ideal ...

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    5. Spontaneous Recanalization of Coronary Thrombus in a Patient With Polycythemia Vera

      Spontaneous Recanalization of Coronary Thrombus in a Patient With Polycythemia Vera

      Spontaneous recanalized coronary thrombi (SRCT), a rare and under-diagnosed entity, are old thrombus formations characterized by multiple communicating channels. We report the case of a 72-year-old female patient who presented with SRCT in the context of polycythemia vera. Optical coherence tomography (OCT) is the diagnostic method of choice

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    6. COMPARISON OF POST STENT OPTICAL COHERENCE TOMOGRAPHY FINDINGS AMONG THREE SUBTYPES OF CALCIFIED CULPRIT PLAQUES IN PATIENTS WITH ACUTE CORONARY SYNDROME

      COMPARISON OF POST STENT OPTICAL COHERENCE TOMOGRAPHY FINDINGS AMONG THREE SUBTYPES OF CALCIFIED CULPRIT PLAQUES IN PATIENTS WITH ACUTE CORONARY SYNDROME

      Background Recently, three subtypes of calcified plaques at the culprit lesion were reported in patients with acute coronary syndrome (ACS): eruptive calcified nodule, superficial calcific sheet, and calcified protrusion. Methods A total of 157 patients with ACS and calcified plaque at the culprit lesion were selected from our database. Optical coherence tomography (OCT) findings at index procedure and after stent implantation were compared among the three subgroups. Results In the final analysis, 92 cases were included. Pre-procedural OCT showed eruptive calcified nodules in 20 (21.7%) cases, superficial calcific sheets in 66 (71.7%), and calcified protrusion in 6 (6 ...

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    7. Coronary Artery Segmentation from Intravascular Optical Coherence Tomography Using Deep Capsules

      Coronary Artery Segmentation from Intravascular Optical Coherence Tomography Using Deep Capsules

      The segmentation and analysis of coronary arteries from intravascular optical coherence tomography (IVOCT) is an important aspect of diagnosing and managing coronary artery disease. However, automated, robust IVOCT image analysis tools are lacking. Current image processing methods are hindered by the time needed to generate these expert-labelled datasets and also the potential for bias during the analysis. Here we present a new deep learning method based on capsules to automatically produce lumen segmentations, built using a large IVOCT dataset of 12,011 images with ground-truth segmentations. This dataset contains images with both blood and light artefacts (22.8%), as well ...

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    8. Comprehensive In Vivo Coronary Plaque Mapping: A 3-Vessel Optical Coherence Tomography Study

      Comprehensive In Vivo Coronary Plaque Mapping: A 3-Vessel Optical Coherence Tomography Study

      Background Previous pathology studies demonstrated that thin-cap fibroatheroma (TCFA) is localized in specific segments of the epicardial coronary arteries. A detailed description of in vivo coronary plaques of various phenotypes has not been reported. Objectives We performed a comprehensive analysis on the distribution of coronary plaques with different phenotypes from our 3-vessel optical coherence tomography (OCT) database. Methods OCT images of all 3 coronary arteries in 131 patients were analyzed every 1 mm to assess plaque phenotype and features of vulnerability. In addition, plaques were divided into tertiles according to percent area stenosis (%AS). Results Among 534 plaques identified in ...

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    9. Comparison of post‐stent optical coherence tomography findings among three subtypes of calcified culprit plaques in patients with acute coronary syndrome

      Comparison of post‐stent optical coherence tomography findings among three subtypes of calcified culprit plaques in patients with acute coronary syndrome

      Objectives To compare the postprocedural optical coherence tomography (OCT) findings and in‐hospital outcomes among the three subtypes of calcified plaques: eruptive calcified nodules, superficial calcific sheet, and calcified protrusion. Background Recently, three subtypes of calcified culprit plaques were reported in patients with acute coronary syndrome (ACS). How these subtypes respond to stenting is unknown. Methods ACS patients with calcified plaque at the culprit lesion were selected from our database. OCT findings at baseline and after stent implantation were compared. Results In the final analysis, 87 cases were included. Preprocedural OCT showed eruptive calcified nodules in 19 (21.8%) cases ...

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    10. Extent of the difference between microcatheter and pressure wire-derived fractional flow reserve and its relation to optical coherence tomography-derived parameters

      Extent of the difference between microcatheter and pressure wire-derived fractional flow reserve and its relation to optical coherence tomography-derived parameters

      Background Although previous studies demonstrated that microcatheter-derived fractional flow reserve (mc-FFR) tends to overestimate lesion severity compared to pressure wire-derived FFR (pw-FFR), the clinical utility of mc-FFR remains obscure. The extent of differences between the two FFR systems and its relation to a lesion-specific parameter remain unknown. In this study, we sought to compare mc-FFR with pw-FFR and determine the lower and upper mc-FFR cut-offs predicting ischemic and non-ischemic stenosis, using an ischemic and a clinical FFR threshold of 0.75 and 0.80 as references, respectively. We further explored optical coherence tomography (OCT) parameters influencing the difference in FFR ...

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    11. In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation

      In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation

      Embryos are growing organisms with highly heterogeneous properties in space and time. Understanding the mechanical properties is a crucial prerequisite for the investigation of morphogenesis. During the last ten years, new techniques have been developed to evaluate the mechanical properties of biological tissues in vivo . To address this need, we employed a new instrument that, via the combination of micro-indentation with Optical Coherence Tomography (OCT), allows us to determine both, the spatial distribution of mechanical properties of chick embryos and the structural changes in real-time provided by OCT. We report here the stiffness measurements on live chicken mesoderm during somite ...

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    12. Method, apparatus, and system to identify branches of a blood vessel

      Method, apparatus, and system to identify branches of a blood vessel

      In part, the disclosure relates to an automated method of branch detection with regard to a blood vessel imaged using an intravascular modality such as OCT, IVUS, or other imaging modalities. In one embodiment, a representation of A-lines and frames generated using an intravascular imaging system is used to identify candidate branches of a blood vessel. One or more operators such as filters can be applied to remove false positives associated with other detections.

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      Mentions: Abbot
    13. In-stent restenosis following third-generation sirolimus-eluting stent implantation: first report analysed from imaging modalities and histopathological findings

      In-stent restenosis following third-generation sirolimus-eluting stent implantation: first report analysed from imaging modalities and histopathological findings

      A 63-year-old man was hospitalized due to unstable angina and was subsequently implanted with a 4.0 × 28 mm third-generation sirolimus-eluting stent (SES) in the proximal left anterior descending artery ( Panels A and B ). Twelve months after implantation, he developed chest pain and underwent coronary angiography which revealed in-stent restenosis (ISR) ( Panels C – E ). Percutaneous coronary intervention was therefore performed. The ISR lesion showed iso and low echoic plaque on intravascular ultrasound (IVUS) ( Panel F ) and a layered pattern on optical coherence tomography (OCT) ( Panel G ). The lesion was resected using a novel directional coronary atherectomy (DCA) catheter (.

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    14. Efficacy of Zotarolimus-Eluting Stents in Treating Diabetic Coronary Lesions: An Optical Coherence Tomography Study

      Efficacy of Zotarolimus-Eluting Stents in Treating Diabetic Coronary Lesions: An Optical Coherence Tomography Study

      Background Diabetes mellitus (DM) plays an important role in restenosis and late in-stent thrombosis (ST). The current study using optical coherence tomography (OCT) aims to compare target lesion neointima in patients with or without diabetes after zotarolimus-eluting stent (ZES) treatment. Methods OCT images of 90,212 struts and quantitative coronary angiography (QCA) in 62 patients (32 with DM and 30 without DM) with 69 de novo coronary lesions (34 DM and 35 non-DM) both after ZES implantation and 12 ± 1 month angiographic follow-up were recorded. Patient characteristics, lesion characteristics, clinical outcomes, and OCT findings including neointimal thickness, coverage, malapposition, and ...

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    15. Postdoctoral researcher on OCT imaging of atherosclerosis

      Postdoctoral researcher on OCT imaging of atherosclerosis

      Published Deadline Location 26 Feb 24 Mar Rotterdam JOB DESCRIPTION Atherosclerosis is an inflammatory and lipid-driven disease of the artery walls. In the coronary circulation, it is the main cause of ischemic heart disease and kills approximately 10 million people per year through myocardial infarctions and subsequent heart failure. Treatment of coronary artery disease by stent implantation can be guided by intravascular imaging with catheter-based optical coherence tomography (IV-OCT). In this project we will realize an OCT system that can perform spectroscopic imaging for identification of atherosclerotic lesion composition. Lipid-rich plaques are associated with worse long-term outcomes for patients. Knowledge ...

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    16. An Unusual Entity: Woven Coronary Artery Anomaly

      An Unusual Entity: Woven Coronary Artery Anomaly

      A 52-year-old female was referred to our catheterization lab due to chest pain and stress-induced myocardial inferior ischemia. Coronary angiography revealed an abnormal segment of the right coronary artery (RCA); its lumen was divided into thin channels with a twisting course reassembling into a single normal lumen in the distal segment of the RCA with TIMI 3 blood flow (Figure 1A; Video 1 ). Optical coherence tomography (OCT) was performed to confirm the presence of a woven coronary artery anomaly (WCAA) (Figure 1B). The similarity of the angiogram to the braided hair gives the name to this entity. WCAA was first ...

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    17. Mechanism of Drug-Eluting Absorbable Metal Scaffold Restenosis: A Serial Optical Coherence Tomography Study

      Mechanism of Drug-Eluting Absorbable Metal Scaffold Restenosis: A Serial Optical Coherence Tomography Study

      Background: The pathomechanisms underlying restenosis of the bioabsorbable sirolimus-eluting metallic scaffold (Magmaris) remain unknown. Using serial optical coherence tomography, we investigated causes of restenosis, including the contribution of late scaffold recoil versus neointimal hyperplasia. Methods: Patients enrolled in BIOSOLVE-II undergoing serial angiography and optical coherence tomography (post-intervention and follow-up: 6 months and/or 1 year) were analyzed. Patients were divided into 2 groups according to angiographic in-scaffold late lumen loss (LLL) <0.5 or ≥0.5 mm. End points were late absolute scaffold recoil and neointimal hyperplasia area as assessed by optical coherence tomography. Results: Serial data were available for ...

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    18. Optical Coherence Tomography for In Vivo Identification, Characterization and Optimal Treatment of Spontaneous Recanalization of Coronary Thrombus

      Optical Coherence Tomography for In Vivo Identification, Characterization and Optimal Treatment of Spontaneous Recanalization of Coronary Thrombus

      Background/Aim: Spontaneous recanalization of coronary thrombus (SRCT) is a rare in vivo appearance, with a nonspecific angiographic aspect. The aim of this study was to investigate the importance of optical coherence tomography (OCT) use for SRCT identification, characterization of pathogenic mechanisms and optimal treatment. Patients and Methods: We retrospectively analyzed all patients with angiographic suspicion of SRCT who underwent coronary angiography for suspected coronary artery disease and afterward investigated by OCT imaging. Results: We identified 28 cases with angiographic suspicion of SCRT (0.41% of CA) and confirmed it in 4 patients (0.05% of CA). OCT provided insight ...

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    19. Identification of atherosclerotic plaques in intravascular optical coherence tomography images based on textures and artificial neural network

      Identification of atherosclerotic plaques in intravascular optical coherence tomography images based on textures and artificial neural network

      Intravascular optical coherence tomography (IVOCT) is becoming an important choice for in vivo diagnosis of coronary artery diseases. The atherosclerotic disease can be detected from IVOCT images, but the segmentation of IVOCT images and identification of plaques are mainly performed manually. This process is laborious and time consuming and its accuracy relies on the expertise of the observer. To address these limitations, a semi-automated identification algorithm based on texture features is presented in this paper. Regions of interest (ROIs) in IVOCT images are firstly selected, then texture features are calculated to represent this ROI. Finally, an artificial neural network is ...

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    20. Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography

      Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography

      A 67-year-old man had angina and dyspnea for several weeks during exercise and rest, and he came to our hospital for coronary angiography. He had mild ST-segment variability, without necrosis markers. Cardiac ultrasonograms revealed moderate mitral regurgitation, preserved ejection fraction, and a posterior-wall infarction scar despite no history of infarction. Coronary angiograms, which revealed no obvious culprit lesion, showed mild focal stenosis in the proximal right coronary artery, distal chronic occlusion of a small left circumflex coronary artery, and mild stenosis and haziness in the mid left anterior descending coronary artery (LAD) (Fig. 1). Suspecting thrombus in the mid LAD ...

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    21. Avinger Announces Publication of SCAN Clinical Study in Peer-Reviewed Journal

      Avinger Announces Publication of SCAN Clinical Study in Peer-Reviewed Journal

      vinger, Inc. (NASDAQ:AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced that the results of its SCAN clinical study have been published in the peer-reviewed journal BMC Medical Imaging. SCAN is a prospective, non-inferiority, post-market study comparing optical coherence tomography (OCT) with intravascular ultrasound (IVUS) as a diagnostic imaging tool in the peripheral arteries. Study results showed that OCT imaging with Avinger's Pantheris system demonstrated statistical superiority or equivalence to IVUS on all parameters evaluated. While OCT has been documented to ...

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      Mentions: FDA Avinger
    22. Assessment of Culprit Lesion of Optical Coherence Tomography in Patients With Acute Myocardial Infarction: a Case Report

      Assessment of Culprit Lesion of Optical Coherence Tomography in Patients With Acute Myocardial Infarction: a Case Report

      In general, patients with acute myocardial infarction (AMI) have severe stenosis secondary to a superimposed thrombus at the event. Optical coherence tomography (OCT) is a useful imaging tool for patients with AMI. This allows us to identify the site of ruptured plaque, erosion of fibrous cap, and characteristics of stenotic lesion. In this case, we present the difference of the ruptured cavity and obstructed lesion.

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