1. Articles in category: Cardiology

    1-24 of 2371 1 2 3 4 ... 97 98 99 »
    1. Comparison of Circulating Dendritic Cells and Monocyte Subsets at Different Stages of Atherosclerosis: insights from optical coherence tomography

      Comparison of Circulating Dendritic Cells and Monocyte Subsets at Different Stages of Atherosclerosis: insights from optical coherence tomography

      Objectives Proinflammatory dendritic cells (DC) and monocytes are critically involved in the proceeding and destabilization of atherosclerosis. Recent studies have reported potential associations of specific patterns of circulating DCs and monocytes with the incidence of coronary artery disease (CAD) and ST-elevation myocardial infarction (STEMI); however, further information of DC and monocyte subsets on plaque morphology and vulnerability is uncertain and required. Methods Forty-seven CAD patients with borderline lesions (stenosis 50%-70%) by coronary angiography (CAG) were enrolled, while 31 subjects free of luminal diameter narrowing ≥ 50% served as controls. Likewise, 35 patients with STEMI were enrolled and confirmed with the ...

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    2. The Role of Multimodality Imaging Approach in Diagnosis and Stratification of Aborted Sudden Cardiac Death

      The Role of Multimodality Imaging Approach in Diagnosis and Stratification of Aborted Sudden Cardiac Death

      A 34-year-old man was admitted after an episode of aborted SCD. The initial investigation including electrocardiogram, chest X-ray, transthoracic echocardiogram and biomarkers were normal. Although coronary angiography showed non-severe stenosis, optical coherence tomography revealed severe obstruction in the artery with a layered appearance of the vessel wall; it was consistent with the presence of mural thrombus.

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    3. Progress of Intravascular Optical Coherence Tomography Image Technology and Vascular Three-Dimensional Reconstruction

      Progress of Intravascular Optical Coherence Tomography Image Technology and Vascular Three-Dimensional Reconstruction

      Intravascular optical coherence tomography (IV-OCT) is a new intervention imaging technology for the diagnosis of coronary heart disease. Because of its high-resolution and non-invasive characteristics, it is widely used in clinical medicine. It has a revolutionary impact on coronary artery disease diagnosis, prognosis and treatment decisions. This paper studied this hot topic, gave the basic concepts of intravascular OCT image sequences. In accordance with current development studies, the key technology for three-dimensional reconstruction of the coronary vascular system is proposed and analyzed. On this basis, we proposed future research directions on IV-OCT vascular three-dimensional reconstruction, including clinical trial frequency domain ...

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    4. Optical Coherence Tomography (OCT) Findings of Coronary Computed Tomography Angiography (CTA) Detected Vulnerable Plaque

      Optical Coherence Tomography (OCT) Findings of Coronary Computed Tomography Angiography (CTA) Detected Vulnerable Plaque

      Background: Recently, coronary computed tomography angiography (CTA) findings of positive vessel remodeling (PR) and low-attenuation plaque (LAP) have been reported to be associated with the development of acute coronary syndromes (ACS). The aim of this study was to examine the CTA detected vulnerable plaque characteristics by using intracoronary optical coherence tomography (OCT). Method and Result: A total of 16 patients with 16 lesions underwent PCI by using intracoronary OCT, after coronary CTA examination, were enrolled in this study. The CTA detected vulnerable plaque (CT-VP) was defined as LAP (<30 hounsfield unit (HU)) with PR of at least 110%. The lesions ...

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    5. Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS?

      Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS?

      It has been questioned for over 15 years why only less than 20% of TCFAs trigger ACS. We illustrate TCFA rupture into adjacent longitudinal necrotic shafts of massive amounts of thrombogenic material into the blood, leading to catastrophic clot formation. This is the potential mechanism for TCFAs triggering ACS. One case presented also illustrates the dangers of stent edges rupturing TCFAs.

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    6. Spontaneous coronary artery dissection: a case series and literature review

      Spontaneous coronary artery dissection: a case series and literature review

      Spontaneous coronary artery dissection (SCAD) is a rare and often lethal cause of acute coronary syndrome, which typically affects young women and otherwise healthy individuals. SCAD can be diagnosed in patients undergoing coronary angiography and can be underestimated. Special techniques such as optical coherence tomography (OCT) and intravascular ultrasound should be used when there is suspicion of the condition. In the majority of cases, the left anterior descending (LAD) artery is involved; however, a few cases of the right coronary artery (RCA) involvement have been reported. This article describes three cases of SCAD in women of different ages, all presenting ...

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    7. Follow up evaluation of unapposed bioresorbable vascular scaffold at a coronary bifurcation using optical coherence tomography

      Follow up evaluation of unapposed bioresorbable vascular scaffold at a coronary bifurcation using optical coherence tomography

      The acute and long term performance of bioresorbable scaffolds (BVS) in treating ostial or bifurcation coronary lesions has not been established. In particular, treatment of these lesions presents the potential problems of non-apposition of struts proximal to the ostium of the vessel or in side branches. Data is also lacking as to whether additional scaffolds can be delivered through struts into side branches for two stent approaches to bifurcations. Despite this there have very few reports of any adverse consequences resulting from their use in these lesions.

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    8. Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data

      Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data

      Aims: To evaluate the implications of an Absorb bioresorbable vascular scaffold (Absorb BVS) on the morphology of the superficial plaques. Methods and results: Forty-six patients who underwent Absorb BVS implantation and 20 patients implanted with bare metal stents (BMS) who had serial optical coherence tomographic examination at baseline and follow-up were included in this analysis. The thin-capped fibroatheromas (TCFA) were identified in the device implantation regions and in the adjacent native coronary segments. Within all regions, circumferential locations of TCFA and calcific tissues were identified, and the neointimal thickness was measured at follow-up. At six to 12-month follow-up, only 8 ...

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    9. Serial Changes of Neointimal Tissue after Everolimus-Eluting Stent Implantation in Porcine Coronary Artery: An Optical Coherence Tomography Analysis

      Serial Changes of Neointimal Tissue after Everolimus-Eluting Stent Implantation in Porcine Coronary Artery: An Optical Coherence Tomography Analysis

      Purposes . The serial changes in neointimal tissues were compared between everolimus-eluting stent (EES) and bare-metal stent (BMS) in the porcine coronary artery using optical coherence tomography (OCT). Methods . Serial (1, 3, and 6 month follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in porcine coronary arteries. Results . In BMS-implanted lesions, neointimal volume decreased from 7.3 mm 3 to 6.9 mm 3 and 6.4 mm 3 at 1, 3, and 6 months follow-up without statistical significance ( ). At the time points of 1, 3, and 6 months, neointimal tissue ...

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    10. Serum Cystatin C Level Not Associated with Coronary Artery Plaque Vulnerability Analyzed by Optical Coherence Tomography

      Serum Cystatin C Level Not Associated with Coronary Artery Plaque Vulnerability Analyzed by Optical Coherence Tomography

      Objectives Cystatin C, which is an endogenous marker for renal function, is reported to be a novel marker for coronary atherosclerosis. Some studies showed that lower cystatin C levels may be associated with increased severity of CAD in clinically stable patients, whereas higher levels may indicate the presence of any vulnerable plaque. To evaluate the relationship of Serum Cystatin C level and the coronary artery plaque vulnerability assessed by OCT in patients with coronary artery disease. Methods Eighty-two patients with chest pain underwent OCT assessment after coronary angiogram, all the lesions with diameter stenosis ≥30% and <100% were analyzed. The ...

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    11. Volcano Corp Banks on IVUS Portfolio amid Several Odds - Analyst Blog

      Volcano Corp Banks on IVUS Portfolio amid Several Odds - Analyst Blog

      On Oct 10, we issued an updated research report on leading precision guided therapy tools provider, Volcano Corporation ( VOLC ). The company retains its position as a leader in the intravascular ultrasound (:IVUS) markets of U.S., Japan and Europe and holds 50% of the global market share.However, the current market environment remains challenging for Volcano. The final reimbursement reduction in Japan led to an approximate 5% cut in Imaging Disposables and an about 2% cut in fractional flow reserve ( FFR ) disposables of Volcano Corporation. These reimbursement cuts will be in effect for the next two years. In addition, the ...

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    12. Epicardial Coronary Artery Compression Secondary to Pericardial Adhesions Demonstrated by Multi-Modality Imaging, and Treated by Coronary Stenting

      Epicardial Coronary Artery Compression Secondary to Pericardial Adhesions Demonstrated by Multi-Modality Imaging, and Treated by Coronary Stenting

      A 42-year-old female presented with sudden onset severe left-sided chest pain radiating to the left arm while watching a movie at home. She was rushed to the hospital within 10 minutes. She was found having ST elevation myocardial infarction on ECG and ventricular fibrillation arrest 2 times requiring cardiac resuscitation and defibrillation. Retrospectively, the patient recalled some ill-defined episodes of chest pain with exercise in the past few months before the admission. Her past surgical history 20 years previous was significant for video-assisted thoracoscopic surgery and pericardial window for removal of large, nonhemorrhagic pericardial effusion of 1.2 L, which ...

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    13. Coronary artery wall imaging

      Coronary artery wall imaging

      Like X-Ray contrast angiography, MR coronary angiograms show the vessel lumens rather than the vessels themselves. Consequently, outward remodeling of the vessel wall, which occurs in subclinical coronary disease before luminal narrowing, cannot be seen. The current gold standard for assessing the coronary vessel wall is intravascular ultrasound, and more recently, optical coherence tomography, both of which are invasive and use ionizing radiation. A noninvasive, low-risk technique for assessing the vessel wall would be beneficial to cardiologists interested in the early detection of preclinical disease and for the safe monitoring of the progression or regression of disease in longitudinal studies ...

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    14. Cardiologists at Chennai hospital combine two latest techniques to treat heart block

      Cardiologists at Chennai hospital combine two latest techniques to treat heart block

      A team of cardiologists at Apollo Hospitals in Chennai have combined two imaging techniques to get a better understanding of blocks formed within the heart blood vessels. Using latest imaging techniques like Fractional Flow Reserve (FFR) and Optical Coherence Tomography (OCT), the team found that a block in a patient had naturally recanalized and had multiple branches. The findings that were published in the Journal of American College of Cardiology highlights the case of a middle aged woman in whom the block was shown as mild in a regular angiogram.

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    15. Delayed coverage of drug-eluting stents after interventional revascularisation of chronic total occlusions assessed by optical coherence tomography: the ALSTER-OCT-CTO registry - See more at: http://www.pcronline.com/eurointervention/ahead_of_print/201410

      Delayed coverage of drug-eluting stents after interventional revascularisation of chronic total occlusions assessed by optical coherence tomography: the ALSTER-OCT-CTO registry - See more at: http://www.pcronline.com/eurointervention/ahead_of_print/201410

      Aims: Following percutaneous coronary interventions (PCI) for revascularisation of chronic total occlusions (CTO) patients are at increased risk for stent thrombosis (ST). Delayed drug-eluting stent (DES) coverage has previously been shown to be related to ST. Using optical coherence tomography (OCT), we tested the hypothesis that CTO-PCI is associated with delayed DES coverage compared to non-CTO lesions. Methods and results: From 06/2010 to 11/2013, 105 patients (111 lesions) with clinically driven follow-up angiography after PCI with DES received an OCT analysis. Patients with successful CTO-PCI (19 patients/20 lesions, 6.5±2.1 months post PCI) were included ...

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    16. Comparison of morphologic findings obtained by optical coherence tomography in acute coronary syndrome caused by vasospasm and chronic stable variant angina

      Comparison of morphologic findings obtained by optical coherence tomography in acute coronary syndrome caused by vasospasm and chronic stable variant angina

      This study used optical coherence tomography (OCT) to evaluate morphologic changes in vasospastic lesions, which can cause acute coronary syndrome (ACS) or chronic stable VA. Thirty-nine patients (52.4 ± 9.0 years, 33 males) with vasospasm-induced ACS who presented with chest pain and displayed transient ST segment elevation on electrocardiography were included in the ACS group. Forty-one patients (49.3 ± 7.7 years, 33 males) who presented with chronic stable variant angina were included in the VA group. The clinical characteristics and morphologic OCT results of the two groups were compared. There were no differences in baseline characteristics, including the ...

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    17. Optical coherence tomography imaging of the patent ductus arteriosus: First known uses in congenital heart disease

      Optical coherence tomography imaging of the patent ductus arteriosus: First known uses in congenital heart disease

      Background: Angiography is used to assess ductal morphology and caliber during interventional closure of the ductus arteriosus. We are evaluating the use of optical coherence tomography (OCT) to evaluate ductal anatomy given the potential benefit of superior resolution and lower radiation. Methods: Standard angiograms were performed on two patients with patent ductus arteriosus prior to device occlusion. OCT was then used to obtain high-resolution three-dimensional vessel reconstructions. Devices were chosen based on angiographic measurements. Results: OCT resulted in excellent three-dimensional anatomic definition, with elliptical narrowest lumenal measurements of 2.2 x 3.1 mm and 1.6 x 2.3 ...

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    18. Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering

      Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering

      Christine Hendon , assistant professor of electrical engineering, has won a $2.4 million five-year New Innovator Award from the National Institutes of Health (NIH), under its High Risk-High Reward program for scientists proposing highly innovative approaches to major contemporary challenges in biomedical research. $900,000 of the award will go to Columbia Engineering in indirect costs. She is one of 50 researchers to receive this prestigious award, established in 2007 for young investigators to conduct exceptionally innovative research. “I am very pleased and honored that my work has received such recognition from the NIH,” says Hendon, whose research is focused ...

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    19. The Role of Optical Coherence Tomography in the Bioresorbable Vascular Scaffold Era

      The Role of Optical Coherence Tomography in the Bioresorbable Vascular Scaffold Era

      Abstract Everolimus-eluting bioresorbable vascular scaffolds (BVS) represent a novel treatment option for coronary artery disease (CAD). Initial and recent clinical results have been promising, although late lumen loss seems to be somewhat higher with BVS compared to everolimus-eluting cobalt chromium stents.1,2 In stable patients free of complex coronary lesions, clinical events reported for BVS at six and 12 months resemble those seen with modern drug-eluting stents (DES).3,4 Thus, while the short-term efficacy and safety of BVS seem to be comparable with modern DES, they may ultimately prove safer. More physiologic vessel healing may translate into decreased ...

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    20. Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography – Pathological Background and Clinical Importance -

      Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography – Pathological Background and Clinical Importance -

      Editorial. Although drug-eluting stents (DES) have dramatically decreased restenosis and target lesion revascularization rates, very late stent thrombosis has emerged as a new problem related to first-generation DES. Abnormal inflammatory vessel response to the polymer has been considered responsible for the development of stent thrombosis.1 Pathological examinations have revealed that in-stent neointima after implantation of a first-generation DES may contain inflammatory cells and fibrin. Recently, optical coherence tomography (OCT) has become widely available as a high resolution intracoronary imaging modality for detecting coronary plaque, providing the detailed morphological features related to unfavorable

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    21. What Is the Optimal Time to Estimate the Final Vascular Response to a Drug-Eluting Stent by Optimal Coherence Tomography?

      What Is the Optimal Time to Estimate the Final Vascular Response to a Drug-Eluting Stent by Optimal Coherence Tomography?

      Editorial. Drug-eluting stents (DES) have significantly reduced the incidence of restenosis and the need of repeat revascularization after percutaneous coronary intervention (PCI).1 Each DES has 3 components, comprising stent strut, polymer and drug. Drugs can be coated on the stent strut and released slowly to suppress cell proliferation over a long duration by virtue of the polymer. However, it is now known that remaining polymer can delay the vascular healing process such as endothelialization by inflammation and localized hypersensitivity, a process that may induce very-late stent thrombosis. 2,3 Therefore, accurate evaluation of the neointimal coverage of DES is ...

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    22. Frequency and predictors of thrombus inside the guiding catheter during interventional procedures: an optical coherence tomography study

      Frequency and predictors of thrombus inside the guiding catheter during interventional procedures: an optical coherence tomography study

      Optical coherence tomography (OCT) is able to identify thrombus. We detect the frequency of thrombus inside the guiding catheter by OCT and its relationship with clinical and procedural factors. We screened 77 patients who underwent OCT pullbacks. Only patients with visible guiding catheter were finally included (35) and divided into thrombus (21) or no-thrombus group (14). Patients within thrombus group were mostly males (100 vs. 71 %, p = 0.05), with acute coronary syndrome (76 vs. 36 %, p = 0.02) and received more frequently percutaneous coronary intervention (86 vs. 43 %, p = 0.01) as compared to other group. A second dose ...

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    1-24 of 2371 1 2 3 4 ... 97 98 99 »
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