1. Articles in category: Cardiology

    1-24 of 2525 1 2 3 4 ... 104 105 106 »
    1. The butler did it! A very late stent thrombosis of TAXUS evaluated with Optical Coherence Tomography

      The butler did it! A very late stent thrombosis of TAXUS evaluated with Optical Coherence Tomography

      A 64 years old male smoker, obese, diabetic non-insulin dependent, dyslipidaemia, presented to our Emergency Department for new onset typical chest pain and EKG signs of an acute anterior ST elevation myocardial infarction. He had an history of a percutaneous coronary interventions to his three vessels with stents TAXUS in 2006 when he presented with stable angina. He performed dual antiplatelet therapy (DAT) for six months, then he assumed aspirin alone.

      Read Full Article
    2. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Objectives This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). Background The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA is unknown. Methods IVUS and OCT examinations identified focal plaques in 165 coronary arteries from 60 autopsy hearts. A total of 685 pairs of images of OCT and IVUS were compared with histology. By OCT, a TCFA was defined as a signal-poor region with diffuse borders and cap thickness <65 μm. By IVUS, a TCFA was defined by ...

      Read Full Article
    3. Late-acquired scaffold malapposition and discontinuity that may be attributable to pathological coronary ectasia: Insights from optical coherence tomography

      Late-acquired scaffold malapposition and discontinuity that may be attributable to pathological coronary ectasia: Insights from optical coherence tomography

      A 69-year-old man presenting with exertional angina, underwent successful percutaneous coronary intervention to the proximal mid-segment of the left circumflex coronary artery with implantation of two Absorb bioresorbable scaffolds (BRS; Abbott vascular, Santa Clara, CA) (Fig. 1A). He returned 16-months later with recurrent symptoms. Coronary angiography revealed focal ectasia and significant in-scaffold restenosis (Fig. 1B). Optical coherence tomography imaging of the ectatic lesion demonstrated a large scaffold lumen diameter (3.74 × 5.04 mm), which was above the upper dilatation limit of the 3.0 mm diameter scaffold and greater than the reference vessel diameter on intravascular ultrasound at the ...

      Read Full Article
    4. Different optical coherence tomography findings for intracoronary stripe-like filling defects on coronary angiogram in patients with acute coronary syndrome

      Different optical coherence tomography findings for intracoronary stripe-like filling defects on coronary angiogram in patients with acute coronary syndrome

      Stripe-like radiolucent filling defects visualized by conventional coronary angiogram (CAG) usually suggest coronary artery dissection. However, recent endovascular imaging technique with high resolution power such as optical coherence tomography (OCT) makes more detailed intraluminal lesion characterization possible, compared with the conventional CAG, and attests to possibilities of being different clinical situation [1]. We report that stripe-like radiolucent filling defects on CAG proved to have different pathophysiologies by OCT in patients with acute coronary syndrome.

      Read Full Article
      Mentions: Korea University
    5. A Honeycomb-Like Structure in Chronic Total Occlusion Demonstrated by Frequency-Domain Optical Coherence Tomography

      A Honeycomb-Like Structure in Chronic Total Occlusion Demonstrated by Frequency-Domain Optical Coherence Tomography

      A 68 year-old male with a history of hypertension and current smoking was admitted due to exertional chest pain. Coronary angiography (CAG) showed a chronic total occlusion (CTO) in the left circumflex artery with collateral supply from the right coronary artery (Fig. 1). PCI was performed in this lesion as patient has normal left ventricular function. After crossing the lesion with guide wire (Gaia 2nd) and micro catheter, frequency-domain optical coherence tomography (FD-OCT) (ILUMIEN™ OCT Imaging System, St Jude Medical, Inc, St Paul, Minnesota) was performed

      Read Full Article
    6. Optical Coherence Tomography during carotid artery stenting: A new niche application?

      Optical Coherence Tomography during carotid artery stenting: A new niche application?

      In the past decades angiography has been the keystone to assess vascular anatomy, leading to the development of largely applied percutaneous revascularisation techniques. However, angiography can only provide a limited analysis of lumen profile without the possibility to disclose vessel wall characteristics and composition of atherosclerotic lesions. Intravascular ultrasound (IVUS), introduced in the early ‘90ies, followed more then a decade after by optical coherence tomography (OCT) provide information about intravascular anatomy that far exceeds the level of detail obtained from conventional angiography.

      Read Full Article
    7. New techniques of intravessel imaging in coronary atherosclerosis

      New techniques of intravessel imaging in coronary atherosclerosis

      Intravascular imaging modalities are currently adopted to circumvent angiographic limitations. The present overview is aimed at describing the principal techniques used by an interventional cardiologist to assess both coronary atherosclerotic plaques and stent deployment results. Optical coherence tomography (OCT), intravascular ultrasound (IVUS), and near-infrared spectroscopy are currently available to address these issues. These techniques are characterized by specific advantages and limitations, making each of those applicable for specific purposes. Offline software programmes have been developed to further characterize plaque tissue, highlighting the macrophage presence or unfold coronary stent in a three-dimensional view by a carpet view. Although IVUS and OCT ...

      Read Full Article
      Mentions: Francesco Prati
    8. Evaluation of hemodynamics changes during interventional stent placement using Doppler optical coherence tomography

      Evaluation of hemodynamics changes during interventional stent placement using Doppler optical coherence tomography

      Carotid atherosclerosis is a critical medical concern that can lead to ischemic stroke. Local hemodynamic patterns have also been associated with the development of atherosclerosis, particularly in regions with disturbed flow patterns such as bifurcations. Traditionally, this disease was treated using carotid endarterectomy, however recently there is an increasing trend of carotid artery stenting due to its minimally invasive nature. It is well known that this interventional technique creates changes in vasculature geometry and hemodynamic patterns due to the interaction of stent struts with arterial lumen, and is associated with complications such as distal emboli and restenosis. Currently, there is ...

      Read Full Article
    9. Association between tissue characteristics assessed with optical coherence tomography and mid-term results after percutaneous coronary intervention for in-stent restenosis lesions: a comparison between balloon angioplasty, paclitaxel-coated balloon dilata

      Association between tissue characteristics assessed with optical coherence tomography and mid-term results after percutaneous coronary intervention for in-stent restenosis lesions: a comparison between balloon angioplasty, paclitaxel-coated balloon dilata

      Aims Morphological assessment of neointimal tissue using optical coherence tomography (OCT) is important for clarifying the pathophysiology of in-stent restenosis (ISR) lesions. The aim of this study was to determine the impact of OCT findings on recurrence of ISR after paclitaxel-coated balloon (PCB) dilatation compared with plain old balloon angioplasty (POBA). Methods and results Between July 2008 and May 2012, we performed percutaneous coronary intervention for 214 ISR lesions using POBA + PCB (146 lesions, PCB group) or POBA only (68 lesions, POBA group). Morphological assessment of neointimal tissue using OCT, including assessment of restenotic tissue structure and restenotic tissue backscatter ...

      Read Full Article
    10. Automated measurement of stent strut coverage in intravascular optical coherence tomography

      Automated measurement of stent strut coverage in intravascular optical coherence tomography

      Optical coherence tomography (OCT) is a non-invasive, cross-sectional imaging modality that has become a prominent imaging method in percutaneous intracoronary intervention. We present an automated detection algorithm for stent strut coordinates and coverage in OCT images. The algorithm for stent strut detection is composed of a coordinate transformation from the polar to the Cartesian domains and application of second derivative operators in the radial and the circumferential directions. Local region-based active contouring was employed to detect lumen boundaries. We applied the method to the OCT pullback images acquired from human patients in vivo to quantitatively measure stent strut coverage. The ...

      Read Full Article
    11. 3-D Stent Detection in Intravascular OCT Using a Bayesian Network and Graph Search

      3-D Stent Detection in Intravascular OCT Using a Bayesian Network and Graph Search

      Worldwide, many hundreds of thousands of stents are implanted each year to revascularize occlusions in coronary arteries. Intravascular optical coherence tomography (OCT) is an important emerging imaging technique, which has the resolution and contrast necessary to quantitatively analyze stent deployment and tissue coverage following stent implantation. Automation is needed, as current, it takes up to 16 hours to manually analyze hundreds of images and thousands of stent struts from a single pullback. For automated strut detection, we used image formation physics and machine learning via a Bayesian network, and 3-D knowledge of stent structure via graph search. Graph search was ...

      Read Full Article
    12. Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma

      Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma

      The hemodynamic environment is known to play a crucial role in the progression, rupture, and treatment of intracranial aneurysms. Currently there is difficulty assessing and measuring blood flow profiles in vivo. An emerging high resolution imaging modality known as split spectrum Doppler optical coherence tomography (ssDOCT) has demonstrated the capability to quantify hemodynamic patterns as well as arterial microstructural changes. In this study, we present a novel in vitro method to acquire precise blood flow patterns within a patient- specific aneurysm silicone flow models using ssDOCT imaging. Computational fluid dynamics (CFD) models were generated to verify ssDOCT results.

      Read Full Article
    13. Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics

      Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics

      Columbia research team creating novel technology to improve diagnosis of peripheral arterial disease A comparison between a cross section of a foot in a healthy and a diabetic patient with peripheral artery disease. The optical tomographic imaging technology shows blood perfusion, or the absence of perfusion, in the issue. Approximately 8 to 12 million people in the United States alone are suffering from peripheral arterial disease (PAD) , a common vascular problem that is also one of the most serious complications of diabetes. Andreas Hielscher, professor of biomedical engineering, electrical engineering and radiology (physics) at Columbia Engineering, is developing a novel ...

      Read Full Article
    14. Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Objectives Fibrous cap thickness is the most critical component of plaque stability. Therefore, in vivo quantification of cap thickness could yield valuable information for estimating the risk of plaque rupture. In the context of preoperative planning and perioperative decision making, intracoronary optical coherence tomography imaging can provide a very detailed characterization of the arterial wall structure. However, visual interpretation of the images is laborious, subject to variability, and therefore not always sufficiently reliable for immediate decision of treatment. Methods A novel semiautomatic segmentation method to quantify coronary fibrous cap thickness in optical coherence tomography is introduced. To cope with the ...

      Read Full Article
    15. Thin Cap Fibroatheroma Defined as Lipid Core Abutting Lumen (LCAL) on Integrated Backscatter Intravascular Ultrasound

      Thin Cap Fibroatheroma Defined as Lipid Core Abutting Lumen (LCAL) on Integrated Backscatter Intravascular Ultrasound

      Background:This study evaluated the ability of a newly developed integrated backscatter intravascular ultrasound (IB-IVUS) system (VISIWAVE, Terumo, Tokyo, Japan) to detect optical coherence tomography (OCT)-verified thin cap fibroatheroma (TCFA) and assessed the correlation with peri-procedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI).Methods and Results:One hundred culprit lesions in 100 consecutive patients with ischemic heart disease who consented to repeated IVUS and OCT prior to PCI were studied. Of 100 lesions, 48 had OCT-verified TCFA with a cap thickness <65 µm. Such lesions had larger percentage lipid area and lipid angle >2 quadrants on IB-IVUS. A ...

      Read Full Article
    16. Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 months Following Biolimus A9-Eluting Biodegradable Polymer Coated Stent Implantation

      Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 months Following Biolimus A9-Eluting Biodegradable Polymer Coated Stent Implantation

      Background Nobori is a biolimus A9-eluting stent (BES) featured with a biodegradable polymer coated on the abluminal side only. We previously reported that favorable vessel healing was achieved at 6-12 months after BES implantation. However, detailed long-term vessel reaction post-BES deployment is unclear. Methods Twenty-two BESs were serially evaluated by optical coherence tomography (OCT) at 6, 12, and 24 months post-stenting. Average neointimal thickness, uncovered struts and neointimal unevenness score (NUS: each cross section as maximum neointimal thickness in one cross section divided by the average neointimal thickness of the same cross-section) were manually measured. In addition, we evaluated the ...

      Read Full Article
    17. Application and Practical Use of Optical Coherence Tomography to Guide Percutaneous Coronary Intervention in Clinical Practice

      Application and Practical Use of Optical Coherence Tomography to Guide Percutaneous Coronary Intervention in Clinical Practice

      Background While many hundreds of studies have been published utilising coronary artery optical coherence tomography (OCT), very few have focused on the application of OCT in daily clinical practice. The following case studies are intended to help guide physicians on specific clinical situations in which OCT can help optimise physician treatment strategies. The cardiac cath lab at Mount Sinai Hospital, New York, New York, is a leader in sharing best practices for improving outcomes in complex coronary cases. Mount Sinai has established guidelines to help drive best practices among interventional cardiologists and fellows in the cath lab. OCT has been ...

      Read Full Article
      Mentions: St. Jude Medical
    18. Vascular Response After Zilver PTX Stent Implantation for Superficial Femoral Artery Lesions Serial Optical Coherence Tomography Findings at 6 and 12 Months

      Vascular Response After Zilver PTX Stent Implantation for Superficial Femoral Artery Lesions Serial Optical Coherence Tomography Findings at 6 and 12 Months

      Purpose: To compare the vascular response after paclitaxel-coated nitinol drug-eluting stent (Zilver PTX) implantation for superficial femoral artery lesions after 6 and 12 months using optical coherence tomography (OCT). Methods: Serial OCT examinations were performed in 5 patients (4 men; mean age 78.4±6.8 years) with 9 Zilver PTX stents at 6- and 12-month follow-up. Variables evaluated included neointimal thickness and apposition on each strut, the incidence of extrastent lumen (ESL), peristrut low-intensity area (PLIA), and neovascularization at 1-mm intervals. Results: A total of 249 matched cross-section images were evaluated and included 4788 and 4826 struts at 6 ...

      Read Full Article
    19. Very late thrombosis observed on optical coherence tomography 22 months after the implantation of a polymer-based bioresorbable vascular scaffold

      Very late thrombosis observed on optical coherence tomography 22 months after the implantation of a polymer-based bioresorbable vascular scaffold

      A 47-year-old man was referred to our catheterization laboratory with an acute coronary syndrome. The patient received a bioresorbable vascular scaffold (BVS, Absorb) in the right coronary artery (RCA) ( Panel A ). The procedure was guided with intravascular ultrasound. Coronary angiography was performed at 22 months due to atypical symptoms and revealed haziness in the RCA ( Panel B ). Optical coherence tomography (OCT) showed homogeneous neointimal proliferation in the previously treated coronary …

      Read Full Article
    20. Optical coherence tomography features of angiographic complex and smooth lesions in acute coronary syndromes

      Optical coherence tomography features of angiographic complex and smooth lesions in acute coronary syndromes

      Plaque rupture (PR) and superimposed thrombosis have been shown as the most frequent underlying substrate in acute coronary syndromes (ACS). Coronary angiography is a luminogram not able to define in vivo features of the culprit plaques. The aim of the study was to use optical coherence tomography (OCT) to investigate the pathology underlying complex (CL) and non-complex angiographic lesions (NCL). We retrospectively enrolled 107 ACS patients admitted to our institution; 83 with non-ST elevation ACS (NSTE-ACS) and 24 with ST-elevation myocardial infarction. Coronary angiography was performed and culprit lesions were classified according to Ambrose criteria into NCL (n = 47) and ...

      Read Full Article
    21. Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis

      Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis

      Aims The aim of this study was to validate novel imaging technology for simultaneous morphological and biochemical endogenous optical imaging of coronary atherosclerotic plaque. Methods and results Optical coherence tomography (OCT) generates high-resolution 3D images of plaque morphology and endogenous fluorescence lifetime imaging microscopy (FLIM) characterizes biochemical composition. Both imaging modalities rely on plaque's intrinsic optical characteristics, making contrast agents unnecessary. A multimodal OCT/FLIM system was utilized to generate luminal biochemical maps superimposed on high-resolution (7 µm axial and 13 µm lateral) structural volumetric images. Forty-seven fresh postmortem human coronary segments were imaged: pathological intimal thickening (PIT, n ...

      Read Full Article
    22. Clinical and pathological characteristics of homogeneous and nonhomogeneous tissue of in-stent restenosis visualized by optical coherence tomography

      Clinical and pathological characteristics of homogeneous and nonhomogeneous tissue of in-stent restenosis visualized by optical coherence tomography

      Background: Although it is known that in-stent restenosis (ISR) patterns appear homogeneous or nonhomogeneous by optical coherence tomography (OCT), interpretations of the ISR inflammatory response, of the OCT image, and its pathological implications are unclear. The aim of this study was to use OCT to characterize ISR and its inflammatory index in patients after coronary stenting. Methods: OCT was performed at follow-up in 100 angiographic ISR lesions. ISR lesions were divided into two groups: (a) homogeneous (n=48) and (b) nonhomogeneous (n=52) image groups. We assessed the ISR images produced by OCT for tissue heterogeneity and neo-intimal hyperplasia using ...

      Read Full Article
    1-24 of 2525 1 2 3 4 ... 104 105 106 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (2 articles) Case Western Reserve University
    2. (2 articles) Erasmus University
    3. (2 articles) Ryerson University
    4. (1 articles) Korea University
    5. (1 articles) University of Texas at Austin
    6. (1 articles) European Society of Cardiology
    7. (1 articles) Iwate Medical University
    8. (1 articles) Columbia University
    9. (1 articles) Yonsei University
    10. (1 articles) University of Tsukuba
    11. (1 articles) University of Toronto
    12. (1 articles) Kobe University Graduate School of Medicine
  4. People in the News

    1. (2 articles) Victor X. D. Yang
    2. (2 articles) Cuiru Sun
    3. (2 articles) Evelyn Regar
    4. (2 articles) Francesco Prati
    5. (2 articles) Yusuke Fujino
    6. (2 articles) Antonios Karanasos
    7. (1 articles) David L. Wilson
    8. (1 articles) Hiram G. Bezerra
    9. (1 articles) Yukio Ozaki
    10. (1 articles) Toshiro Shinke
    11. (1 articles) Hiromasa Otake
    12. (1 articles) Robert-Jan van Geuns
  5. OCT Companies in the News

    1. (2 articles) St. Jude Medical
    2. (1 articles) Terumo Corporation