1. Articles in category: Cardiology

    1-24 of 3441 1 2 3 4 ... 142 143 144 »
    1. An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer-coated sirolimus-eluting stents

      An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer-coated sirolimus-eluting stents

      Objectives The aim of the study was to capture the evolution of neointima after implantation of a biodegradable polymer–coated, sirolimus–eluting, cobalt–chromium coronary stent system (BP-DES). Background Optical coherence tomography (OCT) suggests that in-stent neointimal morphology influences clinical outcomes after DES implantation. Methods Sixty patients treated with single BP-DES implantation were examined by quantitative coronary angiography (QCA) and OCT at 3, 6, and 12-month follow-up. Results Median late lumen loss by QCA (mm) was 0.04 (IQR 0, 0.08), 0.17 (IQR 0, 0.32), and 0.14 (IQR 0.07, 0.31) at 3, 6, and ...

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    2. Atlas of Coronary Intravascular Optical Coherence Tomography (Textbook)

      Atlas of Coronary Intravascular Optical Coherence Tomography (Textbook)

      This atlas is a practical and fully illustrated guide to the use of intravascular OCT in diagnosis and treatment of coronary artery disease. It consists of two parts. The first part of the book provides a systematic introduction to coronary imaging with OCT. It describes how to interpret images and describes abnormal findings seen in atherosclerosis, complications after intervention, and stent assessment. The second part of the book presents real-life case studies that show how OCT is used in clinical practice in Mount Sinai to assess the disease, select appropriate treatment, and evaluate complications and results. Each case includes a ...

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    3. Radial artery neointimal hyperplasia after transradial PCI—Serial optical coherence tomography volumetric study

      Radial artery neointimal hyperplasia after transradial PCI—Serial optical coherence tomography volumetric study

      Aims Transradial catheterization (TRC) is a dominant access site for coronary catheterization and percutaneous coronary interventions (PCI) in many centers. Previous studies reported higher intimal thickness of the radial artery (RA) wall in patients with a previous history of TRC. In this investigation the aim was to assess the intimal changes of RA using the optical coherence tomography (OCT) intravascular imaging in a serial manner. Methods and results 100 patients with the diagnosis of non-ST-elevation myocardial infarction (nSTEMI) treated by PCI were enrolled (6 patients were excluded from this analysis because of occluded RA at follow-up [2 patients] and insufficient ...

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    4. Systems, methods and apparatuses for real-time anastomosis guidance and surgical evaluation using optical coherence tomography

      Systems, methods and apparatuses for real-time anastomosis guidance and surgical evaluation using optical coherence tomography

      A surgical evaluation and guidance system for use in extravacular evaluation and guidance of fluid vessel surgeries, includes an optical coherence tomography engine; a vessel probe optically coupled to the optical coherence tomography engine; and a signal processing and display system adapted to communicate with the optical coherence tomography engine to receive imaging signals therefrom. An optical coherence tomography vessel probe for use in extravacular evaluation and guidance of fluid vessel surgeries, includes a probe body having a proximal end and a distal end; an optical relay system disposed within the probe body; and a vessel adapter at least one ...

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    5. OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging

      OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging

      This study is the sub-study of OPINION Trial. (UMIN000010580) The aim of this study is to evaluate how Optical frequency domain imaging (OFDI) or Intravascular Ultrasound (IVUS) imaging technology influence to the Percutaneous Coronary Intervention (PCI) strategy. Optical frequency domain imaging (OFDI) is a novel, high resolution intravascular imaging modality. Intravascular ultrasound (IVUS) is a widely used conventional imaging modality for achieving optimal stent deployment. This study is the sub-study of OPINION Trial. (UMIN000010580) The aim of this study is to evaluate how OFDI or IVUS imaging technology influence to the Percutaneous Coronary Intervention (PCI) strategy. We will enroll the ...

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    6. Optical Frequency Domain Imaging Versus Intravascular Ultrasound in Percutaneous Coronary Intervention (OPINION Trial) : Results From the OPINION Imaging Study

      Optical Frequency Domain Imaging Versus Intravascular Ultrasound in Percutaneous Coronary Intervention (OPINION Trial) : Results From the OPINION Imaging Study

      Objectives We sought to clarify how intravascular ultrasound (IVUS) and optical coherence tomography affect percutaneous coronary intervention (PCI) with current-generation drug-eluting stents in a pre-specified substudy of the OPINION (OPtical frequency domain imaging versus INtravascular ultrasound in percutaneous coronary interventiON) trial, a multicenter, prospective, randomized, noninferiority trial comparing optical frequency domain imaging (OFDI)-guided PCI with IVUS-guided PCI. Background The impact of these 2 imaging modalities in guiding PCI remains unknown. Methods Of 829 patients enrolled in the OPINION trial, 106 were included in the present imaging substudy. Their PCI was guided by either IVUS or OFDI, but all patients ...

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    7. The role of intracoronary imaging in acute coronary syndromes: OCT in focus

      The role of intracoronary imaging in acute coronary syndromes: OCT in focus

      Optical coherence tomography (OCT) has emerged as a powerful intravascular imaging modality in recent years. The introduction of frequency-domain OCT has simplified the procedure and enabled its safe utilisation in different clinical settings including acute coronary syndromes, where it can determine the mechanism of plaque disruption, thrombus burden, and guide percutaneous coronary intervention. In patients presenting with stent failure (stent thrombosis and instent restenosis), OCT can also be very useful in determining the underlying mechanism and guiding therapy thereafter. This article aims to review the role of OCT in acute coronary syndromes as well as its potential clinical applications. OCT ...

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    8. Feasibility and usefulness of three-dimensional optical coherence tomography guidance for optimal side branch treatment in coronary bifurcation stenting

      Feasibility and usefulness of three-dimensional optical coherence tomography guidance for optimal side branch treatment in coronary bifurcation stenting

      Background For the treatment of coronary bifurcation lesions, optimal guidewire (GW) recrossing after main vessel stenting is important for good stent apposition at the side branch (SB) orifice in kissing balloon inflation (KBI). Methods We analyzed 150 bifurcation lesions treated with single stenting following KBI in the three-dimensional optical coherence tomography (3D-OCT) bifurcation registry study (2015–16) and a single center experience (2012–16). OCT examination was performed after GW recrossing to the SB and after KBI. Patients were divided into two-dimensional (2D, n = 78) and 3D groups ( n = 72) according to 2D- or 3D-OCT guidance. GW recrossing position, jailing ...

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    9. Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study

      Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study

      Background Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic structural findings of MB remain to be fully elucidated. Recently, we demonstrated that optical coherence tomography (OCT) enables us to visualize adventitial vasa vasorum (VV) formation in humans. In this study, we examined adventitial VV formation at the coronary segment with MB in humans using OCT. Methods We examined 15 consecutive patients with suspected angina pectoris and MB in the left anterior descending (LAD) coronary arteries but no angiographic coronary stenosis. MB was detected on coronary ...

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    10. University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives a 2017 NIH Grant for $78,500 for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue. The principal investigator is Benjamin Sherlock. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. Cardiovascular disease is a leading cause of death globally. In vitro engineering of replacement blood vessels has emerged as a promising area of research that has the potential to provide lifesaving therapy in patients where autologous bypass grafts are not possible. The challenges of vascular tissue engineering require the developing samples ...

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    11. Off-Line Fusion of Intravascular Ultrasound and Optical Coherence Tomography Images

      Off-Line Fusion of Intravascular Ultrasound and Optical Coherence Tomography Images

      Intravascular ultrasound (IVUS) and optical coherence tomography (IV-OCT) are widely used interventional imaging modalities to visualize vascular morphologies and identify atherosclerotic plaques. IVUS has high detection depth and low spatial resolution while IV-OCT has high resolution and poor tissue penetration. This work presents a registration and fusion method for IV-OCT and IVUS images acquired on a same vessel segment by separate imaging catheters. First, an IVUS image matched with an IV-OCT image is retrieved from the image sequence based on the Fourier descriptor of the detected lumen contour. Then, the IVUS image elastically deforms according to the geometrical transformation parameters ...

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    12. Stent accordion phenomenon visualized with optical coherence tomography

      Stent accordion phenomenon visualized with optical coherence tomography

      Percutaneous coronary intervention (PCI) was done in a 57-year-old male with chronic kidney disease who presented with non-ST segment elevation myocardial infarction. Coronary angiogram showed two vessel disease of the left anterior descending artery (LAD) and the right coronary artery (RCA). The LAD was successfully stented. After predilatation and rotablation, PCI was performed with 2 overlapping drug eluting stents (DES) Promus (Boston Scientific, Marlborough, Massachusetts, USA) 3 mm × 38 mm to the mid RCA and Resolute Onyx 3.5 mm × 34 mm (Medtronic, Minneapolis, Minnesota, USA) to the ostial proximal segment, respectively. After post dilatation using a 3.5 non-compliant ...

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    13. Integrated Coronary Imaging Registry

      Integrated Coronary Imaging Registry

      The coronary images of selective angiography and optical coherence tomography with FFR(Fractional Flow Reserve) values of the intermediate lesions (50-70% stenosis) will be prospectively registered. The coronary images of selective angiography and optical coherence tomography with FFR(Fractional Flow Reserve) values of the intermediate lesions (50-70% stenosis) will be prospectively registered. The patients with intermediate lesions after CT angiography and invasive coronary angiography will be screened, and optical coherence tomography, FFR and selective CT angiography will be performed. The coronary images and FFR values will be registered, and the patients will be followed-up up to 2 years to investigate ...

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    14. Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT

      Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT

      Objectives The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUS–virtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. Background IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. Methods Anatomic landmarks and endoluminal radiopaque markers were used to fuse OCT and IVUS images and match baseline and follow-up. Results Seventy-two IVUS–virtual histology and OCT paired matched cross-sectional in- and out-scaffold segments were fused ...

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    15. Impact of coronary lumen reconstruction on the estimation of endothelial shear stress: in vivo comparison of three-dimensional quantitative coronary angiography and three-dimensional fusion combining optical coherent tomography

      Impact of coronary lumen reconstruction on the estimation of endothelial shear stress: in vivo comparison of three-dimensional quantitative coronary angiography and three-dimensional fusion combining optical coherent tomography

      Aims It is not clearly elucidated how the fusion technique improves the accuracy of endothelial shear stress (ESS) prediction, in comparison with that of three-dimensional (3D) quantitative coronary angiography (QCA) alone. We aimed to evaluate the difference in geometric measurements and haemodynamic estimation between 3D QCA and a 3D fusion model combining 3D QCA and optical coherence tomography (OCT). Methods and results Computational fluid dynamics was assessed in the coronary models of 20 patients. In the plane-per-plane comparison, the difference and agreement were assessed using a generalized linear mixed model and concordance correlation coefficient (CCC), respectively. The haemodynamic feature around ...

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    16. Avinger Receives CE Marking Approval for In-Stent Restenosis Treatment Indication With Pantheris Image-Guided Atherectomy

      Avinger Receives CE Marking Approval for In-Stent Restenosis Treatment Indication With Pantheris Image-Guided Atherectomy

      Avinger, Inc. (NASDAQ: AVGR ), a leading developer of innovative treatments for Peripheral Artery Disease (PAD), today announced Conformité Européenne (CE) Marking approval for treating in-stent restenosis with the Pantheris® Lumivascular atherectomy system. In-stent restenosis occurs when a previously blocked artery treated with a stent becomes narrowed again, blocking blood flow. Physicians often face challenges when treating in-stent restenosis both in terms of safety and efficacy. From a safety standpoint, limitations in imaging techniques such as X-ray fluoroscopy and the inability to control the directionality of other treatment modalities’ mechanism of action creates the concern of potentially impacting the integrity ...

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    17. Effect of Post-Dilatation Following Primary PCI With Everolimus-Eluting Bioresorbable Scaffold Versus Everolimus-Eluting Metallic Stent Implantation: An Angiographic and Optical Coherence Tomography TROFI II Substudy

      Effect of Post-Dilatation Following Primary PCI With Everolimus-Eluting Bioresorbable Scaffold Versus Everolimus-Eluting Metallic Stent Implantation: An Angiographic and Optical Coherence Tomography TROFI II Substudy

      Objectives This study sought to investigate the effect of post-dilatation on angiographic and intracoronary imaging parameters in the setting of primary percutaneous coronary intervention comparing the everolimus-eluting bioresorbable scaffold (BRS) with the everolimus-eluting metallic stent (EES). Background Routine post-dilatation of BRS has been suggested to improve post-procedural angiographic and subsequent device-related clinical outcomes. Methods In the ABSORB STEMI TROFI II trial, 191 patients with ST-segment elevation myocardial infarction were randomly assigned to treatment with BRS (n = 95) or EES (n = 96). Minimal lumen area and healing score as assessed by optical coherence tomography at 6 months were compared between BRS- ...

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    18. Real-time optical coherence tomography coregistration with angiography in percutaneous coronary intervention–impact on physician decision-making: The OPTICO-integration study

      Real-time optical coherence tomography coregistration with angiography in percutaneous coronary intervention–impact on physician decision-making: The OPTICO-integration study

      Aims Intracoronary optical coherence tomography (OCT) imaging allows for high-resolution characterization of coronary lesions. Difficulties in matching cross-sectional OCT-images with angiographic lesion localization may limit optimal clinical utilization. We sought to prospectively assess the impact of a novel system of real-time OCT coregistration with angiography (ACR) on physician decision-making during percutaneous coronary interventions (PCI). Methods and Results Strategy for PCI (stent - length, - diameter, - strategy, landing zone) and PCI-optimization (stent-malappostion, -underexpansion, edge-dissections, geographical mismatch) was prospectively assessed in 50 patients with 58 coronary lesions after (I) angiography, (II) OCT imaging, and (III) ACR. Preprocedural OCT imaging altered stent-length (58.9%), diameter ...

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    19. Neointimal coverage of jailed side branches in coronary bifurcation lesions: an optical coherence tomography analysis

      Neointimal coverage of jailed side branches in coronary bifurcation lesions: an optical coherence tomography analysis

      Objectives: The jailed strut at the side-branch (SB) orifice may be a cause of delayed neointimal coverage and SB flow disturbance after single stenting to bifurcation. The aim of this study was to characterize the exact relationship between the jailed strut pattern at the SB orifice immediately after stent implantation and neointimal coverage of the jailed SB orifice in the chronic phase. Patients and methods: A total of 29 bifurcation (left anterior descending coronary artery and diagonal branch) lesions treated by optical coherence tomography-guide single-stent implantation and followed at 18 months after a percutaneous coronary intervention were included in this ...

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    20. Plaque Progression: Slow Linear or Rapid Stepwise?

      Plaque Progression: Slow Linear or Rapid Stepwise?

      Atherosclerosis was thought to be a disease of insidious onset and slow process, secondary to smooth muscle cell proliferation. 1 However, this concept was challenged during the past 2 decades by the theory that an alternative mode of rapid step-wise plaque progression might also exist. This sudden change in arterial lumen occurs when mural thrombus is organized after disruption of a plaque or by sudden expansion of a plaque secondary to intraplaque hemorrhage. Because of the sudden change in local geometry, this second mode is significant not only to rapid plaque progression, but also to the development of acute coronary ...

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    21. Tissue characterization with depth-resolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images

      Tissue characterization with depth-resolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images

      An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate the backscatter-related term in IVOCT images, such that values can be estimated per pixel without predefining any delineation for the estimation. In order to exclude noisy regions with a weak ...

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    22. Long-term Invasive Follow-up of Bioresorbable Vascular Scaffold: Optical Coherence Tomography Assessment of Jailed Side Branches

      Long-term Invasive Follow-up of Bioresorbable Vascular Scaffold: Optical Coherence Tomography Assessment of Jailed Side Branches

      Background Little is known about the long term development of the tissue bridges covering the struts of bioresorbable vascular scaffold (BVS) at the side branches (SB) ostium. This study aims at assessing the resorption process of jailed SB after BVS implantation. Methods We performed both Optical Coherence Tomography (OCT) and Intravascular Ultrasound (IVUS) analysis of 7 patients enrolled in the ABSORB Cohort B trial at our center. Orifice SB area and mean thickness of tissue bridge covering SB were calculated from 2D assessment. The number of SB orifice compartments separated by BRS struts was analyzed by using 3D OCT reconstruction ...

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