1. Articles in category: Cardiology

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    1. Avinger Announces Full Commercial Launch of Pantheris SV

      Avinger Announces Full Commercial Launch of Pantheris SV

      Avinger, Inc. (NASDAQ: AVGR ), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the full commercial launch of the Pantheris SV (small vessel) image-guided atherectomy system in the U.S. All current and prospective Lumivascular accounts are now eligible to order the Pantheris SV device. Avinger launched Pantheris SV at select Avinger sites in late July in order to demonstrate the product's ease of use and efficiency across a variety of user approaches and vascular conditions in a real-world clinical setting, as well ...

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      Mentions: Avinger
    2. Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry

      Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry

      Objectives The aim of this study was to compare angiographic and optical coherence tomography findings following subintimal as opposed to intraplaque recanalization of chronic total occlusions (CTOs). Background There is ongoing controversy regarding outcomes of intraplaque versus subintimal CTO recanalization. Methods Consecutive patients undergoing angiography and intravascular optical coherence tomography following CTO recanalization were included in the ISAR-OCT-CTO (Intracoronary Stenting and Angiographic Results - Optical Coherence Tomography for Chronic Total Occlusions) registry. The study endpoints were percent diameter stenosis and late lumen loss as well as rate of uncovered and malapposed struts. Independent correlates of uncovered and malapposed struts were assessed ...

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    3. Effect of evolocumab therapy on coronary fibrous cap thickness assessed by optical coherence tomography in patients with acute coronary syndrome

      Effect of evolocumab therapy on coronary fibrous cap thickness assessed by optical coherence tomography in patients with acute coronary syndrome

      Background The addition of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, evolocumab, to statin therapy produced incremental regression of atherosclerotic plaques and a collaborative prevention of cardiovascular events in patients with coronary artery disease. The effect on fibrous-cup thickness, or extension of the atherosclerotic plaque with PCSK9-inhibitor, for several weeks after onset of acute coronary syndrome (ACS) has never been reported. Methods This study aimed to examine the effect of evolocumab on fibrous-cap thickness, as well as the extent of the atherosclerotic plaque, by serial optical coherence tomography (OCT) analysis in patients with ACS. All patients received rosuvastatin 5 ...

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    4. Intracoronary pressure increase due to contrast injection for optical coherence tomography imaging

      Intracoronary pressure increase due to contrast injection for optical coherence tomography imaging

      Background Optical coherence tomography (OCT) requires intracoronary injection of contrast media to remove blood from the field of view during image acquisition. Contrast injection may cause a temporal increase in intracoronary pressure. The aim of this study was to compare the intracoronary pressure during contrast injection between OCT and coronary angiography . Methods We measured intracoronary pressure by using a pressure guidewire during contrast injection for OCT and angiography in 30 coronary arteries (mean fractional flow reserve = 0.90 ± 0.03). Contrast media was injected into coronary artery through the guiding catheter by using a mechanical injector pump. Results Intracoronary pressure ...

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    5. Avinger Announces Commercial Launch and First Patients Treated in Hong Kong

      Avinger Announces Commercial Launch and First Patients Treated in Hong Kong

      Avinger, Inc. (NASDAQ:AVGR), a commercial-stage medical device company marketing the first-ever image-guided, catheter-based system for the diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the commercial launch of its Lumivascular products in Hong Kong. Avinger has an exclusive distribution agreement with Integmed Ltd. for the sale and marketing of Avinger’s Pantheris image-guided atherectomy and Ocelot image-guided chronic total occlusion (CTO) crossing systems in Hong Kong. The first shipment of devices has been made under the agreement and training of Integmed’s sales and clinical support teams has been completed. Dr. Yiu Che Chan, a highly-experienced vascular ...

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    6. Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University

      Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University

      We have a postdoctoral opportunity to advance new solutions in cardiovascular and ophthalmological biomedical imaging using machine and deep learning approaches. Projects include mass screening of disease, diagnosis/staging, treatment evaluation, and image guided therapies. A particular opportunity exists in coronary artery intravascular OCT, where we use biomechanical experiments, deep learning. and finite element modeling with the intention of creating software to help plan interventional treatments. Trainees will have an opportunity to join and learn from the wide ranging biomedical imaging community at Case Western Reserve University, which includes the Center of Computational Imaging and Personalized Diagnostics (CCIPD), the Case ...

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    7. Second-generation drug-eluting absorbable metal scaffold target-lesion revascularization: an optical coherence tomography case series study and literature review

      Second-generation drug-eluting absorbable metal scaffold target-lesion revascularization: an optical coherence tomography case series study and literature review

      Bioresorbable scaffolds (BRS) were introduced into clinical practice to overcome long-term limitations of drug-eluting stents (DES), but they were instead associated with a high rate of target lesion revascularization (TLR) and thrombosis. Whereas scaffold discontinuity was the most frequent mechanism for polymeric-BRS TLR1, there are no studies on the causes of second-generation drug-eluting absorbable metal scaffold (MgBRS) TLR (Magmaris, BIOTRONIK, Bulach, Switzerland). We sought to determine the optical coherence tomography (OCT) findings in patients who experienced a MgBRS TLR. Moreover, we performed a systematic review of the reported cases. 

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    8. Intracoronary imaging for the diagnosis of the underlying substrate and clinical management of acute coronary syndromes: from evidence to expert consensus … and back!

      Intracoronary imaging for the diagnosis of the underlying substrate and clinical management of acute coronary syndromes: from evidence to expert consensus … and back!

      ntracoronary imaging (ICI) has matured into a well-established clinical and research tool for patients with coronary artery disease (CAD). Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are now widely accepted for the assessment of lesion morphology in patients presenting with acute coronary syndromes (ACS). The large body of evidence gathered on the clinical value of these techniques cannot be summarised in a conventional clinical practice guideline format. Accordingly, a recent expert consensus document on the importance of ICI to guide coronary interventions 1 has now been followed by another expert consensus detailing the value of these techniques to unravel ...

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    9. Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      This consensus document is the second of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS)-IVUS. Beyond guidance of stent selection and optimization of deployment, invasive imaging facilitates angiographic interpretation and may guide treatment in acute coronary syndrome. Intravascular imaging can provide additional important diagnostic information when confronted with angiographically ambiguous lesions and allows assessment of plaque morphology enabling identification of vulnerability characteristics. This second document focuses on useful ...

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    10. 3D Optical Coherence Tomography Reveals Fractured Coronary Stent as Cause of Acute Myocardial Infarction

      3D Optical Coherence Tomography Reveals Fractured Coronary Stent as Cause of Acute Myocardial Infarction

      A 61-year-old male presented with anterior ST-segment elevation. Emergency coronary angiography demonstrated complete occlusion of the left anterior descending (LAD) coronary artery, which was treated with primary percutaneous intervention. Following predilation, a 2.5 mm x 38 mm Xience V drug-eluting stent (Abbott Vascular) was implanted. Due to coronary calcification, the distal portion of the stent was repeatedly postdilated with a 3 mm x 15 mm non-compliant balloon (NC Trek; Abbott Vascular) to ensure adequate stent expansion. The final angiographic result was good. The patient was readmitted 2 days later with recurrence of chest pain and anterior ST-segment elevation. Repeat ...

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    11. Acute stent malapposition: Harmful or harmless?

      Acute stent malapposition: Harmful or harmless?

      Acute Stent malapposition (ASM) is the post-procedure lack of contact of stent struts with vessel wall. Operators are naturally displeased when ASM is revealed by intravascular imaging modalities, such as optical coherence tomography (OCT), because previous studies have reported presence of ASMs in patients suffering from stent thrombosis [1–3]. Actually, ASMs are not that rare [4–6]. We should be aware of what we should do when we encounter the cases of ASM. Many of us may consider postdilation to correct a malapposition with a larger balloon or higher pressure, especially in cases with coexisting stent underexpansion.

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    12. Optimization of Percutaneous Coronary Intervention Using Optical Coherence Tomography

      Optimization of Percutaneous Coronary Intervention Using Optical Coherence Tomography

      Compared to the luminogram obtained by angiography, intravascular modalities produce cross-sectional images of coronary arteries with a far greater spatial resolution. It is capable of accurately determining the vessel size and plaque morphology. It also eliminates some disadvantages such as contrast streaming, foreshortening, vessel overlap, and angle dependency inherent to angiography. Currently, the development of its system and the visualization of coronary arteries has shown significant advancement. Of those, optical coherence tomography (OCT) makes it possible to obtain high-resolution images of intraluminal and transmural coronary structures leading to navigation of the treatment strategy before and after stent implantations. The aim ...

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    13. Optical Coherence Tomography: Defined Plaque Erosion after Removal of a Coronary Guidewire

      Optical Coherence Tomography: Defined Plaque Erosion after Removal of a Coronary Guidewire

      A 45-years-old male patient presented with a non-ST elevation myocardial infarction (MI). Coronary angiography revealed only mild luminal stenosis in the middle portion of the left anterior descending artery ( Figure 1 ). For evaluation of the culprit lesion of an acute MI (AMI), intravascular optical coherence tomography (OCT) was performed ( Figure 2A , Supplementary Video 1 ). A few cross-sectional OCT images at angiographically mildly stenotic segments showed a suspicious presence of an intracoronary thrombus adjacent to the acoustic shadow by the guidewire artifact ( Figure 2B-F ), leading to an undetermined cause of the pathomechanism of the AMI. Therefore, the guidewire was removed from ...

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    14. Ongoing thrombosis assessed by optical coherence tomography

      Ongoing thrombosis assessed by optical coherence tomography

      Two interesting cases of coronary percutaneous intervention (PCI) are presented, describing the very early phase of vascular thrombosis after in-stent restenosis (ISR) treatment and resorbable scaffold implantation using optical coherence tomography (OCT) imaging, which required a change of therapeutic attitude. The first patient is a 51-year-old woman with hypertension, dyslipidemia and type 2 diabetes, and a history of non-ST-elevation myocardial infarction one year prior, with anterior descending artery (ADA) revascularization by implantation of two overlapping anfilimus-eluting stents (Cre8 3*25 and 2.75*12 mm). An angiographic examination performed one year later due to progressive angina revealed severe focal ISR ...

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    15. Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: report of 3 cases

      Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: report of 3 cases

      Studies evaluating individuals for endothelial injury after endovascular thrombectomy (EVT) have been done by means of retrieved human thrombus, MR vessel-wall imaging, and animal histopathological studies. These techniques have limitations, because MR imaging has insufficient spatial resolution to directly visualize endothelium, and histopathological examinations are performed ex vivo and are unable to provide real-time patterns of injury. The purpose of the current study was to obtain in vivo intraluminal imaging after EVT by using optical coherence tomography (OCT), examining for evidence of endothelial injury in real time. Three consecutive patients with acute basilar artery occlusion underwent OCT imaging immediately after ...

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    16. Quality Assurance Specialist Conavi Medical

      Quality Assurance Specialist Conavi Medical

      See your future at Conavi! Join our collaborative and entrepreneurial team designing and manufacturing minimally invasive innovative imaging solutions to improve cardiac care around the world. Conavi Medical’s Foresight ICE catheter is the world's first intracardiac echo system with the capability to acquire 2D and 3D images with a broad field-of-view that includes both side-viewing and forward-looking capabilities. Our Novasight Hybrid System enables simultaneous imaging of coronary arteries with both intravascular ultrasound (IVUS) and Optical Coherence Tomography (OCT). If you would like to be a part of our growing and talented team that is making a difference, we ...

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    17. Temporal Trends in the Use of Intravascular Imaging Among Patients Undergoing Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction in the United States.

      Temporal Trends in the Use of Intravascular Imaging Among Patients Undergoing Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction in the United States.

      Intravascular imaging (intravascular ultrasound, IVUS and optical coherence tomography, OCT) are recommended tools to optimize stent placement during percutaneous coronary intervention (PCI). 1 The use of intravascular imaging is increasing among patients undergoing PCI for non-ST elevation myocardial infarction (NSTEMI). 2 Data on temporal trends of intravascular imaging use in the setting of ST elevation myocardial infarction (STEMI) are unknown. We performed this study to analyze trends of intravascular imaging for PCI in setting of STEMI.

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    18. Multicentre Registry of CCTA, IVUS and OCT

      Multicentre Registry of CCTA, IVUS and OCT

      The Invictus Registry will compare the diagnostic performance of coronary computed tomography angiography (CCTA) versus intravascular imaging by intravenous ultrasound (IVUS) or optical coherence tomography (OCT) for the measurement of minimum lumen area, the identification of stenosis severity, burden, morphology and vulnerability of coronary atherosclerosis.

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    19. Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank

      Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank

      The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture held annually, bringing together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community. During the SCAI 2019 Scientific Sessions, relevant topics in interventional cardiology were identified with the goals of defining the state of the field, current challenges, and future directions. Topics were determined by nomination, and solidified through a voting process ultimately vetted by SCAI leadership and the industry relations committee. The 2019 Think Tank was organized into four parallel sessions reflective of the field of interventional cardiology: (a) coronary intervention, (b ...

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    20. Culprit lesion morphology in young patients with st-segment elevated myocardial infarction: A clinical, angiographic and optical coherence tomography study

      Culprit lesion morphology in young patients with st-segment elevated myocardial infarction: A clinical, angiographic and optical coherence tomography study

      Background and aims About 20% of patients with ST-segment elevated myocardial infarction (STEMI) are young adults. Morphological characteristics of culprit lesion in young STEMI patients have not been systematically evaluated in vivo . The present study aimed to investigate culprit lesion characteristics in young patients versus older patients using optical coherence tomography (OCT). Methods 1442 STEMI patients who underwent OCT examination of culprit lesion were included and divided into young group (age ≤50 years, n = 400) and older group (age >50 years, n = 1042). Clinical characteristics, angiography and OCT findings were compared between the two groups. Results Culprit lesions in STEMI ...

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    21. Diagnostic accuracy of 320-row computed tomography for characterizing coronary atherosclerotic plaques: Comparison with intravascular optical coherence tomography

      Diagnostic accuracy of 320-row computed tomography for characterizing coronary atherosclerotic plaques: Comparison with intravascular optical coherence tomography

      Background/Purpose. This study sought to determine the diagnostic accuracy of 320-row computed tomography (320CT) for characterizing coronary atherosclerotic plaques in comparison with optical coherence tomography (OCT). Methods/Materials. From 32 patients, 42 coronary segments were evaluated and co-registered by both 320CT and OCT. 320CT vulnerable plaque characteristics included low attenuation plaque (LAP) (<30HU), napkin-ring sign (NRS), positive remodeling (PR) and spotty calcification (SC). The presence of macrophage, neovascularization and cholesterol crystals was also determined by OCT. Results Minimal lumen area was 2.78 ± 1.23 mm by OCT and 3.29 ± 1.49 mm by 320CT ( p < 0.001 ...

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    22. Avinger Announces Presentations by Key Opinion Leaders at AMP 2019 Clinical Conference

      Avinger Announces Presentations by Key Opinion Leaders at AMP 2019 Clinical Conference

      Avinger, Inc. (NASDAQ: AVGR ), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for the diagnosis and treatment of Peripheral Artery Disease (PAD), today announced four podium presentations featuring the Company’s Lumivascular technology at the annual AMP (Amputation Prevention Symposium) conference occurring last week. Key opinion leaders in the fields of interventional cardiology highlighted Avinger ’s Lumivascular technology, which includes the Pantheris family of image-guided atherectomy products and the Ocelot family of image-guided chronic total occlusion (CTO) crossing products, in the following sessions: Dr. Thomas Davis, an interventional cardiologist at Eastlake Cardiovascular and one ...

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      Mentions: Avinger
    23. Looking into the Future: Optical Coherence Tomography for the Assessment of Cardiac Allograft Vasculopathy

      Looking into the Future: Optical Coherence Tomography for the Assessment of Cardiac Allograft Vasculopathy

      ntroduction Current guidelines recommend coronary angiography with intravascular ultrasound (IVUS) as a screening and surveillance tool for the assessment of cardiac allograft vasculopathy (CAV). The role of optical coherence tomography (OCT) has not been thoroughly evaluated for patients with CAV. Case Description A 59 M with history of ICM with subsequent OHT in 2016 with evidence of an eccentric LAD plaque and CAV with IMT of 0.66 mm on IVUS being treated with Rosuvastatin and Sirolimus presented for second annual follow up angiogram. On coronary angiography all of his vessels appeared angiographically “pristine” without evidence of vasculopathy (Figure 1 ...

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    24. In-Stent Restenosis Lesion Morphology Related to Repeat Stenting Underexpansion as Evaluated by Optical Coherence Tomography

      In-Stent Restenosis Lesion Morphology Related to Repeat Stenting Underexpansion as Evaluated by Optical Coherence Tomography

      Aims: To use optical coherence tomography (OCT) to predict newly implanted stent expansion for treatment of in-stent restenosis (ISR). Methods and results: With OCT-guidance, 143 ISR lesions were treated with a new stent. Stent underexpansion was defined as minimum stent area (MSA) <4.5mm 2 and MSA/average of reference lumen area <70%. New stent underexpansion was found in 33 lesions (23%), had a smaller old stent MSA (4.13 [3.32-4.62] versus 5.18 [4.01-6.38] mm 2 , p=0.001), and had a higher prevalence of multiple old stent layers (51.5% versus 10.9%, p ...

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