1. Articles in category: Cardiology

    1-24 of 3203 1 2 3 4 ... 132 133 134 »
    1. Neoatherosclerosis in the Iliac Artery Stent ― Insights From Optical Coherence Tomography and Intravascular Ultrasound ―

      Neoatherosclerosis in the Iliac Artery Stent ― Insights From Optical Coherence Tomography and Intravascular Ultrasound ―

      There has been increasing attention on neoatherosclerosis in coronary arteries following implantation of bare-metal and drug-eluting stents.1,2 Neoatherosclerosis might be a concern even in the field of peripheral artery disease (PAD). A 75-year-old man with hypertension, diabetes mellitus, dyslipidemia and a history of right iliac artery stenting with a Wallstent 12 years previously, was referred to hospital for treatment of recurrent/progressive intermittent claudication (Rutherford category 3) that had started 6 months earlier. Ankle brachial index (ABI) was 0.51 on the right. Diagnostic angiography showed significant in-stent restenosis in the right iliac artery stent (Figure A). Intravascular ...

      Read Full Article
    2. Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography

      Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography

      The composition of plaque is a major determinant of coronary-related clinical syndromes. By combining photoacoustic tomography (PAT) and optical coherence tomography (OCT), the optical absorption and scattering properties of vascular plaque can be revealed and subsequently used to distinguish the plaque composition and structure. The feasibility and capacity of the dual-mode PAT-OCT technique for resolving vascular plaque was first testified by plaque composition mimicking experiment. PAT obtained lipid information due to optical absorption differences, while owing to scattering differences, OCT achieved imaging of collagen. Furthermore, by combining PAT and OCT, the morphological characteristic and scattering difference of normal and lipid-rich ...

      Read Full Article
    3. Development of a new catheter prototype for laser thrombolysis under guidance of optical coherence tomography (OCT): validation of feasibility and efficacy in a preclinical model

      Development of a new catheter prototype for laser thrombolysis under guidance of optical coherence tomography (OCT): validation of feasibility and efficacy in a preclinical model

      In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There were four experimental groups: placebo, 20 mg alteplase, laser, 20 mg alteplase + laser. The extent of thrombolysis was analyzed by weighing, OCT imaging and relative thrombus size. In the alteplase group, thrombus size decreased to 0.250 ± 0.036 g (p < 0.0001) and 14.495 ± 0.526 mm 2 (p < 0 ...

      Read Full Article
    4. Comparisons of Morphological Measurement Between Coronary Computed Tomography and Optical Coherence Tomography

      Comparisons of Morphological Measurement Between Coronary Computed Tomography and Optical Coherence Tomography

      The objective of this study is to evaluate the precision of semi-automated lumen boundary identification from coronary computed tomography angiography (cCTA) by current version of HeartFlow software and the impact on fractional flow reserve (FFRCT) by using optical coherence tomography (OCT) as reference standard.

      Read Full Article
    5. Ex Vivo Assessment of Coronary Atherosclerotic Plaque by Grating-Based Phase-Contrast Computed Tomography: Correlation With Optical Coherence Tomography

      Ex Vivo Assessment of Coronary Atherosclerotic Plaque by Grating-Based Phase-Contrast Computed Tomography: Correlation With Optical Coherence Tomography

      Objectives: The aim of this study was to determine the diagnostic accuracy of grating-based phase-contrast computed tomography (gb-PCCT) to classify and quantify coronary vessel characteristics in comparison with optical coherence tomography (OCT) and histopathology in an ex vivo setting. Materials and Methods: After excision from 5 heart specimens, 15 human coronary arteries underwent gb-PCCT examination using an experimental imaging setup consisting of a rotating molybdenum anode x-ray tube, a Talbot-Lau grating interferometer, and a single photon counting detector. Subsequently, all vessels were imaged by OCT and histopathologically processed. Optical coherence tomography, gb-PCCT, and histopathology images were manually matched using anatomical ...

      Read Full Article
    6. Optical coherence tomography assessment of a complex bifurcation lesion treated with double kissing Crush technique: A case report

      Optical coherence tomography assessment of a complex bifurcation lesion treated with double kissing Crush technique: A case report

      The DEFINITION (Impact of the complexity of bifurcation lesions treated with drug-eluting stents) study has provided a novel classification to evaluate the complexity of coronary bifurcation lesion according to coronary angiography, but angiographic imaging due to its low resolution and inherited limitation may result in an inaccurate adjudication. We used optical coherence tomography (OCT) to further evaluate the coronary characteristics in a patient with “simple” bifurcation lesion which was classified by the DEFINITION criteria. However, a “complex” bifurcation lesion was defined and confirmed according to the OCT results. A double kissing Crush stenting approach was adopted to treat this “complex ...

      Read Full Article
    7. Beth Isreal Deaconess Medical Center Receives Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Isreal Deaconess Medical Center Receives Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Isreal Deaconess Medical Center Receives a 2017 NIH Grant for $164,376 for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology. The principal investigator is Eric Osborn. The program began in 2017 and ends in 2020. Below is a summary of the propose work. Dr. Eric Osborn is an early career faculty member at Beth Israel Deaconess Medical Center (BIDMC) and Massachusetts General Hospital (MGH), and an Instructor in Medicine at Harvard Medical School, Boston, Massachusetts. He is a graduate of the MD-PhD program at Harvard Medical School and Massachusetts Institute of Technology, and has completed clinical training in medicine ...

      Read Full Article
    8. Plaque erosion causing ST-segment elevation myocardial infarction: report of an optical coherence tomography-documented case and concise literature review

      Plaque erosion causing ST-segment elevation myocardial infarction: report of an optical coherence tomography-documented case and concise literature review

      A 61-year-old man presented to the Emergency Room of a referring hospital with anterior ST-segment elevation myocardial infarction (STEMI) and was immediately treated by antiplatelet therapy and transferred to our hospital to perform a primary percutaneous coronary intervention (PCI)...

      Read Full Article
      Mentions: Rocco Vergallo
    9. Optical Coherence Tomography For the Detection of the Vulnerable Plaque

      Optical Coherence Tomography For the Detection of the Vulnerable Plaque

      Morphological characteristics of the atheromatous plaque have been associated with the development of plaque rupture and the pathogenesis of acute coronary syndromes (ACS). Plaques with a specific morphological phenotype that are at high risk of causing ACS are called vulnerable plaques, and can be identified in vivo through the use of intracoronary imaging. Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality that enables detailed visualization of atheromatous plaques. Consequently, OCT is a valuable research tool for examining the role of morphological characteristics of atheromatous plaques in the progression of coronary artery disease and plaque destabilisation, which leads to ...

      Read Full Article
    10. Assessment of Coronary Plaque Vulnerability in Acute Coronary Syndromes using Optical Coherence Tomography and Intravascular Ultrasound. A Systematic Review

      Assessment of Coronary Plaque Vulnerability in Acute Coronary Syndromes using Optical Coherence Tomography and Intravascular Ultrasound. A Systematic Review

      The aim of this systematic review was to analyze studies characterizing vulnerable coronary plaques using optical coherence tomography (OCT) and intravascular ultrasound (IVUS), in order to identify the most efficient invasive technique permitting plaque characterization in patients with acute myocardial infarction. Method: A total number of 432 studies were identified, 420 through database searching and 12 through manual searching. Eight duplicate studies were removed, leaving a total number of 424 studies to be screened. Twenty-six studies only available in abstract-only form were excluded, resulting in 398 studies checked for eligibility. Eleven studies fulfilled the eligibility criteria and were included in ...

      Read Full Article
    11. Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study

      Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study

      Aims: This study sought to investigate differences in vascular response between self-expanding bare metal nitinol stents (BMS) and paclitaxel-eluting nitinol stents (PES), in superficial femoral artery (SFA) disease, using optical frequency domain imaging (OFDI). Methods and results: Six months after stent implantation, follow-up quantitative vascular angiography (QVA) and OFDI assessment were scheduled to evaluate vascular response. Volume index (VI) was defined as volume divided by stent length. The primary endpoint was OFDI-derived late lumen area loss, defined as lumen VI post stent implantation minus lumen VI at follow-up. A total of 28 SFA lesions were analysed, with cases randomised to ...

      Read Full Article
    12. Intracoronary Imaging

      Intracoronary Imaging

      Two intracoronary imaging techniques are routinely available to complement angiography in the management of coronary artery disease, namely intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The former has been in clinical use for >25 years and has directly informed the fundamentals of atherosclerotic plaque composition and arterial remodelling, as well as contemporary optimal stent implantation technique. 1 , 2 The latter, introduced 10 years ago, has only been more widely adopted with the development of the frequency domain (FD)-OCT imaging, which enables complete image acquisition over a 6–10 cm segment during a 3–5 s pullback period obtaining ...

      Read Full Article
    13. Abnormality of retinal arterial velocity profiles using Doppler Fourier-domain optical coherence tomography in a case of Takayasu's arteritis with aortic regurgitation

      Abnormality of retinal arterial velocity profiles using Doppler Fourier-domain optical coherence tomography in a case of Takayasu's arteritis with aortic regurgitation

      Purpose To evaluate the retinal microcirculation using a segmental-scanning Doppler optical coherence tomography (DOCT) flowmeter in a patient with Takayasu's arteritis (TA) with aortic valve regurgitation (AR). Observations We measured the retinal blood velocity (V), retinal blood flow (RBF), and retinal blood velocity profiles (RBVP) of the major retinal arterioles using a DOCT flowmeter. The arteries were measured at the straight portion 1 disc diameter from the optic disc. Horizontal velocity profiles were extracted to evaluate the RBVP during one cardiac cycle. A patient with TA with stage 2 Takayasu retinopathy (TR) and AR, had normal RBF and V ...

      Read Full Article
    14. Vessel Intimal Extraction of Coronary Optical Coherence Tomography Imagery Based on an Improved CV Model

      Vessel Intimal Extraction of Coronary Optical Coherence Tomography Imagery Based on an Improved CV Model

      Optical coherence tomography (OCT) is a novel technology used in coronary artery disease diagnosis for its high resolution. It has numerous advantages in 3D vessel modeling and vulnerable plaque quantification. This paper proposes a robust vessel intimal extraction algorithm using active contours. A pre-processing module, that takes into consideration the characteristics of coronary OCT imagery, is introduced to eliminate a variety of visual disruptions. Then, a monotonically decreasing function is added into the Chan-Vese (CV) method in order to avoid over segmentation. This is done by controlling the evolution speed in closing the boundary area. A postprocess is followed after ...

      Read Full Article
    15. Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry

      Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry

      Aim. To determine the potential clinical impact of OCT (Optical Coherence Tomography) during primary percutaneous coronary intervention in patients presenting with ACS (Acute Coronary Syndrome). Methods and Results. FORMIDABLE is a multicentre retrospective registry enrolling all patients presenting with ACS and treated with an OCT-guided approach, while the USZ registry enrolled patients treated with a standard angiography guided approach. Multivariate adjustment was performed via a propensity score matching. The number stents useds was the primary outcome, while the incidence of MACE (a composite of death, myocardial infarction, target vessel revascularization, and stent thrombosis) was the secondary endpoint. A total of ...

      Read Full Article
    16. Optical Coherence Tomography to Evaluate Plaque Burden and Morphology in Patients With Takotsubo Syndrome

      Optical Coherence Tomography to Evaluate Plaque Burden and Morphology in Patients With Takotsubo Syndrome

      ackground Disrupted atherosclerotic plaques in the left anterior descending coronary artery are discussed controversially as a potential pathophysiological mechanism in Takotsubo syndrome ( TTS ). Therefore, the aim of the present study was to assess plaque burden and morphology by using optical coherence tomography in patients with TTS . Methods and Results A total of 23 consecutive TTS patients were included in this single‐center study and underwent optical coherence tomography imaging of the left main coronary artery and the left anterior descending coronary artery at acute presentation. All patients fulfilled the established diagnostic criteria for TTS and the diagnosis was confirmed with ...

      Read Full Article
    17. The impact of blood pressure variability on coronary plaque vulnerability in stable angina: an analysis using optical coherence tomography

      The impact of blood pressure variability on coronary plaque vulnerability in stable angina: an analysis using optical coherence tomography

      Background: Blood pressure variability (BPV), especially visit-to-visit BPV, has been reported to be a risk factor for cardiovascular disease. The impact of BPV on coronary plaque vulnerability remains uncertain. The aim of this study was to investigate the relationship between BPV and coronary plaque vulnerability. Patients and methods: From August 2013 to May 2014, 36 patients with both hypertension and stable angina pectoris who underwent a percutaneous coronary intervention guided by frequency-domain optical coherence tomography were investigated retrospectively. The size of the lipid cores and the thickness of the fibrous cap covering the lipid core were measured by frequency-domain optical ...

      Read Full Article
    18. Not all plaque ruptures are born equal: an optical coherence tomography study

      Not all plaque ruptures are born equal: an optical coherence tomography study

      Aims Plaque rupture (PR) represents the most common substrate of coronary thrombosis, in at least 50% of cases. Chronic low grade inflammation is a common background for atherosclerosis development; however, increased plaque inflammation may predispose by itself to PR. In the last decade, studies performed by optical coherence tomography (OCT) have allowed to establish the severity of plaque inflammation by assessing macrophage infiltration (MØI). Our retrospective study aimed at assessing the role of plaque inflammation in PR among patients with acute coronary syndrome (ACS) using OCT. Methods and results We enrolled 56 patients with ACS exhibiting PR at the ...

      Read Full Article
      Mentions: Rocco Vergallo
    19. EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging

      EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging

      Aims: Qualitative criteria for plaque tissue characterisation by OCT are well established, but quantitative methods lack systematic validation in vivo . High optical attenuation coefficient µ t has been associated with unstable plaque features, such as lipid core. The purpose of this study was to validate optical coherence tomography (OCT) attenuation imaging for tissue characterisation in vivo , specifically to detect lipid core in coronary atherosclerotic plaques, and to evaluate quantitatively the ability of OCT attenuation imaging to differentiate thin-cap (TCFA) and thick-cap fibroatheroma (FA). Methods and results: We prospectively enrolled 85 patients undergoing imaging of a native coronary segment by both OCT ...

      Read Full Article
    20. Mother-and-child catheter-facilitated optical coherence tomography: A novel approach to improve intracoronary imaging

      Mother-and-child catheter-facilitated optical coherence tomography: A novel approach to improve intracoronary imaging

      Background: Our aim was to prospectively analyze the usefulness of mother-and-child catheter approach with the GuideLiner® (GL) catheter extension system to overcome some potential limitations associated with the use of optical coherence tomography (OCT). Methods: We included consecutive patients referred to our institution for coronary angiogram in whom OCT image acquisition was obtained using GL. From February 2015 to May 2016, a total of 19 procedures (18 patients) were prospectively included. Results: In more than two thirds of the procedures, the OCT catheter was unable to cross the coronary stenosis prior to the use of GL. The right coronary artery ...

      Read Full Article
      Mentions: Fernando Alfonso
    21. Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by

      Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by

      Background Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT). Methods We prospectively enrolled 38 consecutive patients with ULM disease, whom were treated with single-stent procedure using DES, crossover the ULM-left anterior descending artery (LAD) following by KBT. Twelve patients were ...

      Read Full Article
    1-24 of 3203 1 2 3 4 ... 132 133 134 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (2 articles) Harvard University
    2. (2 articles) Erasmus University
    3. (2 articles) Massachusetts General Hospital
    4. (1 articles) Tohoku University
    5. (1 articles) Stanford University
    6. (1 articles) Beth Israel Deaconess Medical Center
    7. (1 articles) Kumamoto University
    8. (1 articles) Massachusetts Institute of Technology
    9. (1 articles) University of Catania
    10. (1 articles) National Institutes of Health
    11. (1 articles) Royal Brompton Hospital
    12. (1 articles) Case Western Reserve University
  4. People in the News

    1. (2 articles) Hiram G. Bezerra
    2. (2 articles) Konstantinos Toutouzas
    3. (2 articles) Antonios Karanasos
    4. (2 articles) Guilherme F. Attizzani
    5. (2 articles) Rocco Vergallo
    6. (1 articles) Guillermo J. Tearney
    7. (1 articles) Felix I. Feldchtein
    8. (1 articles) Grigory V. Gelikonov
    9. (1 articles) Natalia D. Gladkova
    10. (1 articles) Giovanni J. Ughi
    11. (1 articles) Peter Libby
    12. (1 articles) Robert-Jan van Geuns
  5. OCT Companies in the News

    1. (1 articles) Avinger