1. Articles in category: Patents

    1-24 of 1697 1 2 3 4 ... 69 70 71 »
    1. Spectral optical coherence tomography

      Spectral optical coherence tomography

      The invention relates to an apparatus for generating a scannable optical delay for a beam of light and an apparatus for Fourier domain optical coherence tomography having said apparatus for generating a scannable optical delay in its reference arm (15). The light beam is directed to a pivotably driven mirror (10) from where it is reflected to a fixed mirror (12), and from there back retro reflected along the reference arm (5). Lens optics (9) are provided to ensure accurate optical alignment in several pivot positions of the pivotably driven mirror (10).

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    2. Two-dimensional confocal imaging using OCT light source and scan optics

      Two-dimensional confocal imaging using OCT light source and scan optics

      Various approaches are disclosed for simultaneously generating optical coherence tomography (OCT) and confocal scanning laser images by spatially separating the signal normally used for OCT imaging with selective reflecting or beam directing devices. In one preferred embodiment, the invention includes a mirror having a central transmission region, such that the radially outer region of the returning signal beam is reflected and used for generating a confocal image while the central part of the signal beam is transmitted and used to generate an OCT image. In other embodiments, the signals may be spatially separated in other ways, such as with an ...

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    3. Method and system for analyzing optical coherence tomography (OCT) results using color reflectivity discretization analysis

      Method and system for analyzing optical coherence tomography (OCT) results using color reflectivity discretization analysis

      A method of analyzing an OCT image. An OCT image has many differently colored dots. The system detects the number of differently colored dots, quantifies them and performs statistical analysis to determine a likelihood of disease. The different colored dots correspond to different retina cell types and structures.

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    4. Imaging probe with combined ultrasound and optical means of imaging

      Imaging probe with combined ultrasound and optical means of imaging

      The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image, signals during scanning a region of interest.

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    5. Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

      Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

      OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length ...

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    6. Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

      Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

      Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first ...

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    7. Monitoring blood constituent levels in biological tissue

      Monitoring blood constituent levels in biological tissue

      In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in ...

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    8. Image capture apparatus and method

      Image capture apparatus and method

      It has been very cumbersome to determine whether or not alignment is required before the fundus image is acquired after the tomographic image is acquired, causing the reduction in diagnostic efficiency. An ophthalmic apparatus is provided to solve this problem, which comprises an irradiation unit that irradiates an eye to be inspected with a first beam for acquiring a tomographic image of the eye and a second beam for acquiring a fundus image of the eye, the second beam having a beam diameter larger than the beam diameter of the first beam; and a determination unit that, based on information ...

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    9. Polarization scrambling based on cascaded optical polarization devices having modulated optical retardation

      Polarization scrambling based on cascaded optical polarization devices having modulated optical retardation

      Techniques and devices use cascaded optical polarization devices having modulated optical retardation to control optical polarization of light and can be configured for polarization scrambling. Uniform rate scrambling and quasi-uniform rate scrambling modes are provided in described devices and rate-additive designs based on multiple cascaded devices are also disclosed to achieve high-speed scrambling.

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    10. Surgical microscopes using optical coherence tomography and related methods

      Surgical microscopes using optical coherence tomography and related methods

      Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls ...

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    11. Enhanced imaging for optical coherence tomography

      Enhanced imaging for optical coherence tomography

      An imaging device to obtain images, comprising: an optical source; an x-y scanner receiving light from the optical source and directing it onto a sample; a detector receiving reflected light from the scanner; and a computer receiving a signal from the detector and providing a 3D data set containing voxels with a given voxel resolution of a sample, the computer further executing instructions for finding values other than a single axes sum to represent a set of voxels; composing a 2D image using the values.

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      Mentions: Optovue
    12. Electrothermal microactuator for large vertical displacement without tilt or lateral shift

      Electrothermal microactuator for large vertical displacement without tilt or lateral shift

      A microactuator for displacing a platform vertically with respect to a substrate includes a first rigid frame, a first flexible bimorph beam connecting the first frame to the substrate, a second rigid frame, a second flexible bimorph beam connecting the second frame to the first frame, and a third flexible bimorph beam connecting a platform to the second frame. Activation of the first, second, and third flexible bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A microactuator assembly includes a substrate, a plurality of first rigid frames, a plurality of first ...

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    13. Imaging system and method using partial-coherence speckle interference tomography

      Imaging system and method using partial-coherence speckle interference tomography

      A system for generating an image of contoured surface includes a light source that is configured to project an electromagnetic radiation beam onto the contoured surface, wherein the projected beam generates first radiation reflected from a first portion of the contoured surface to form a speckle pattern, and second radiation reflected from a second portion of the contoured surface which is substantially uniform in intensity. The reflected first and second reflected radiation is received by an optical detector, and may be processed. The processing is configured to (1) generate a plurality of images from the first and second reflected radiation ...

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    14. Capsule camera with variable illumination of the surrounding tissue

      Capsule camera with variable illumination of the surrounding tissue

      The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system ...

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    15. Systems and methods for imaging and processing tissue

      Systems and methods for imaging and processing tissue

      In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging layers of the tissue, sectioning a portion of the tissue, capturing the sectioned tissue, and imaging additional layers of the tissue in a second volume of the tissue, and capturing each portion of sectioned tissue, and processing three-dimensional data that is collected to ...

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    16. Scanning and processing using optical coherence tomography

      Scanning and processing using optical coherence tomography

      In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 ...

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    17. Device with an OCT system for examining and treating living tissue by means of heating of the tissue by absorbing electromagnetic radiation

      Device with an OCT system for examining and treating living tissue by means of heating of the tissue by absorbing electromagnetic radiation

      A device for examining or treating living tissue by means of local heating of the tissue by absorbing electromagnetic radiation, with at least one radiation source emitting electromagnetic radiation, a control unit for controlling the irradiation parameters of the radiation source, and at least one FD-OCT apparatus with a light source emitting a measurement light for illuminating that tissue region in which the electromagnetic radiation is absorbed by the tissue, characterized by a computational unit for carrying out the following steps: determining the depth-resolved tissue velocity in the radiation direction of the measurement light at a predetermined measurement point of ...

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    18. Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories

      Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories

      An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a ...

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    19. Method And System For Determining Whether Arterial Tissue Comprises Atherosclerotic Plaque

      Method And System For Determining Whether Arterial Tissue Comprises Atherosclerotic Plaque

      Provided herein are methods and systems to determine at least one mechanical property of a tissue sample and, based upon the determined at least one mechanical property, whether the tissue sample comprises atherosclerotic plaque. The method comprises generating a shear wave in an arterial tissue sample by applying an acoustic impulse thereto; measuring propagation of the shear wave via an optical coherence elastography apparatus; determining at least one mechanical property of the arterial tissue sample based on the propagation of the shear wave; and comparing the at least one mechanical property of the arterial tissue sample to a reference data ...

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    20. Handheld imaging probe

      Handheld imaging probe

      A handheld imaging probe for performing optical coherence tomography is disclosed. The handheld imaging probe includes a lens tube and a housing. The lens tube contains an objective lens and a polycarbonate sheet. The polycarbonate sheet provides a bio-safe contact with a tissue sample to be examined. The housing, which is connected to the lens tube, contains a micromirror for directing a laser beam to irradiate the tissue sample via the objective lens and the polycarbonate sheet.

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    21. Time domain-frequency domain optical coherence tomography apparatus and methods for use

      Time domain-frequency domain optical coherence tomography apparatus and methods for use

      An optical coherence tomography (OCT) system comprising: a splitter configured to receive and split an optical source beam generating a reference beam and a sample beam, the sample beam directed at a sample and interacting with the sample to generate a return beam; a delay module configured to receive and introduce an optical delay in the reference beam, to generate a delayed reflected beam configured to interfere with the return beam to generate an interferogram; a spatial filter system capable of filtering randomly scattered light from at least one of the return beam or the interferogram; and a detector array ...

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    22. Multispot monitoring for use in optical coherence tomography

      Multispot monitoring for use in optical coherence tomography

      Optical coherence tomography (herein "OCT") based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for ...

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    23. Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging

      Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging

      An imaging probe for a biological sample includes an OCT probe and an ultrasound probe combined with the OCT probe in an integral probe package capable of providing by a single scanning operation images from the OCT probe and ultrasound probe to simultaneously provide integrated optical coherence tomography (OCT) and ultrasound imaging of the same biological sample. A method to provide high resolution imaging of biomedical tissue includes the steps of finding an area of interest using the guidance of ultrasound imaging, and obtaining an OCT image and once the area of interest is identified where the combination of the ...

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    1-24 of 1697 1 2 3 4 ... 69 70 71 »
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