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New scheme for polarimetric glucose sensing without polarizers
Explore Article SPIE Digital Library (Feb 25 2010) Glucose , Ophthalmology
Polarimetric glucose sensing is a promising method for noninvasive estimation of blood glucose concentration. Published methods of polarimetric glucose sensing generally rely on measuring the rotation of light as it traverses the aqueous humor of the eye. In this article, an interferometer is described that can detect polarization changes due to glucose without the use of polarization control or polarization analyzing elements. Without polarizers, this system is sensitive to optical activity, inherent to glucose, but minimally sensitive to linear retardance, inherent to the cornea. The underlying principle of the system was experimentally verified using spectral domain optical coherence tomography. A ...
Comment on Article Mentions: Jennifer K. Barton Amy M. Winkler Garret T. Bonnema
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Full-Field Optical Coherence Tomography for the Rapid Estimation of Epidermal Thickness
Explore Article Optical Coherence Tomography News (Jan 16 2010) Dermatology , Glucose
Feature Of The Week 1/17/10: A number of recent developments in non-invasive physiological monitoring of the human body have demonstrated a high potential for the use of such techniques in the in vivo estimation of various clinically relevant parameters such as haemoglobin content and its’ oxygen
Comment on Article Mentions: Heliotis AG Andreas Caduff Isabel Kolm
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Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography
Explore Article www3.interscience.wiley.com (Oct 12 2009) Dermatology , Glucose
Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that ...Comment on Article Mentions: Kirill V. Larin University of Houston Saratov State University
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Recent Developments in Less Invasive Technology to Monitor Blood Glucose Levels in Patients with Diabetes
Explore Article LabMedicine (Sep 19 2009) Glucose
In this review we discuss recent developments focused on less invasive methods of self monitoring for diabetes mellitus. The gold standard for self monitoring currently involves a small device measuring the blood glucose level in a droplet of blood taken from the fingertip or forearm of a patient. This lancet approach is done on average 3–4 times a day and can be uncomfortable and inconvenient. It is known that monitoring blood glucose more frequently leads to better control and maintaining overall health. However, invasiveness of the finger stick method has caused patients to ignore the need to monitor their blood ... -
Methods And Systems For Analyte Level Estimation In Optical Coherence Tomography (Wo 2009/111542)
Explore Article wipo.int (Sep 11 2009) Glucose , Patents
Optical coherence tomography (herein 'OCT') based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple ...Comment on Article Mentions: GlucoLight Philip W. Wallace Matthew J. Schurman
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The Retinal Function in Relation to Glucose Changes
Explore Article Home - ClinicalTrials.gov (Sep 8 2009) Glucose , Ophthalmology , Clinical Trials
This project has the following specific purposes: To develop a clinically usable test to determine the blood glucose level or HbA1c-level, to which the retina is adapted. This will be performed by means of ERG implicit time measurements in relation to the blood glucose level during an oral glucose tolerance test (OGTT) and inter- or extrapolation to the level of blood glucose (or HbA1c) where implicit time is normal. To examine darkadaptation in diabetics in relation to changes in the glucose level. To examine vessel diameter changes in diabetic individuals when changing the glucose level transiently -
Multiple reference non-invasive analysis system
Explore Article PatFT » Page 1 of 1 (Apr 28 2009) Glucose , Patents
A non-invasive imaging and analysis system suitable for measuring concentrations of specific components, such as blood glucose concentration and suitable for non-invasive analysis of defects or malignant aspects of targets such as cancer in skin or human tissue, includes an optical processing system which generates a probe and composite reference beam. The system also includes a means that applies the probe beam to the target to be analyzed and modulates at least some of the components of the composite reference beam such that signals with different frequency content are generated. The system combines a scattered portion of the probe beam ... -
OCT based method for diagnosis and therapy
Explore Article PatFT » Page 1 of 1 (Mar 31 2009) Glucose , Patents
This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a physiological perturbation and measuring the response of the microsample to the perturbation using optical coherence tomography (OCT). In an exemplary embodiment, the concentration of glucose in the microsample is perturbed, as by providing the subject with a high glucose drink, and subsequently monitoring at a high sample rate in a microsample by OCT. Pathology, such as diabetes, can be diagnosed by deviation of the concentration vs. ...Comment on Article Mentions: GlucoLight Matthew J. Schurman
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Effect of temperature on permeation of low-density lipoprotein particles through human carotid artery tissues
Explore Article www3.interscience.wiley.com (Mar 11 2009) Cardiology , Glucose
Quantification of the diffusion of small molecules and large lipid transporting lipoproteins across arterial tissues could be useful in elucidating the mechanism(s) of atherosclerosis. Optical coherence tomography (OCT) was used to determine the effect of temperature on the rate of diffusion of glucose and low-density lipoproteins (LDL) in human carotid endarterectomy tissue in vitro. The permeability rate for glucose was calculated to be (3.51 ± 0.27) × 10-5 cm/s (n = 13) at 20 °C, and (3.70 ± 0.44) × 10-5 cm/s (n = 5) at 37 °C; for LDL the rate was (2.42 ± 0.33) × 10-5 cm/s (n ...Comment on Article Mentions: Kirill V. Larin University of Houston Mohamad G. Ghosn
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The nonlinear relationship between concentration of analyte and its permeability coefficient in ocular tissues
Explore Article SPIE Digital Library (Feb 23 2009) Glucose
Monitoring and quantifying the permeability of different drugs and chemical solutions through ocular tissues is of great importance due to its potential use in pharmacological research. In this study, Optical Coherence Tomography, a relatively new innovation in biomedical imaging was used for the functional imaging of glucose diffusion in the sclera of the eye. The permeability coefficient for different glucose concentrations was quantified non-destructively in order to compare the effect of glucose concentration on its rate of diffusion. In these in vitro experiments, fresh New Zealand white rabbit eyes were imaged during the diffusion of different glucose concentrations (10, 15, ...
Comment on Article Mentions: Kirill V. Larin Valery V. Tuchin Mohamad G. Ghosn
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Determination of glucose concentration using Fourier domain optical coherence tomogram
Explore Article SPIE Digital Library (Feb 23 2009) Glucose
In order to enhance cell culture growth in biosensors such as those for glucose detection must be developed that are capable of monitoring cell culture processes continuously and accurate. Fourier domain optical coherence tomography (FD-OCT) is used to obtain cell images with nanometer level resolut ... [Proc. SPIE 7182, 71821L (2009)] published Mon Feb 23, 2009. -
Quantifying the effect of milli-molar glucose concentration on thickness of rabbit cornea with optical coherence tomography
Explore Article SPIE Digital Library (Feb 20 2009) Glucose , Ophthalmology
The cornea contributes about 65% of the eye's ability to refract light. Thus, any fluctuation in corneal thickness can cause noticeable changes in vision. The presence of glucose molecules induces a driving force for water to leave the collagen fibrils in the cornea due to the concentration gradient created, thus changing its thickness. In this study, the effect of various milli-molar glucose concentrations on corneal thickness was explored using Optical Coherence Tomography. Whole rabbit eyes were placed in a specially designed dish while immersed in saline to ensure proper hydration of the eye. The cornea was imaged for 10 minutes. ...Comment on Article Mentions: Kirill V. Larin Mohamad G. Ghosn University of Houston
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Newton Photonics wins NSF grant for new glucose meter
Explore Article masshightech.com (Nov 30 2008) Glucose , Funding
The National Science Foundation has awarded a nearly half-million dollar grant to startup Newton Photonics Inc. to create a non-invasive optical sensor capable of continuously monitoring a patient’s glucose levels. The NSF made the $480,000 Phase 2 Small Business Innovation Research (SBIR) award on Nov. 3, explained the Newton-based company’s co-founder Shmuel Halevi. The firm specializes in making biophotonic sensors. The NSF cash will fund the company’s effort to create the glucose-monitoring instrument using proprietary Optical Coherence Tomography (OCT) technology. Currently, no company has released to market a glucose monitor using OCT. Existing technologies from larger companies require the patient’s ...Comment on Article Mentions: GlucoLight Shmuel Halevi Newton Photonics
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Newton Photonics Wins a NSF SBIR Grant for OCT Glucose Monitor
Explore Article Your Diabetes May Vary (Nov 28 2008) Glucose , Funding
The National Science Foundation has awarded a nearly half-million dollar grant to startup Newton Photonics Inc. to create a non-invasive optical sensor capable of continuously monitoring a patient’s glucose levels. The NSF made the $480,000 Phase 2 Small Business Innovation Research (SBIR) award on Nov. 3, explained the Newton-based company’s co-founder Shmuel Halevi. The firm specializes in making biophotonic sensors. The NSF cash will fund the company’s effort to create the glucose-monitoring instrument using proprietary Optical Coherence Tomography (OCT) technology. Currently, no company has released to market a glucose monitor using OCT. Existing technologies from larger companies require the patient’s ...Comment on Article Mentions: GlucoLight Shmuel Halevi Newton Photonics
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Study of Correlation Between Glucose Concentration and Reduced Scattering Coefficients in Turbid media using Optical Coherence Tomography
Explore Article arxiv.org (Aug 3 2008) Glucose
Noninvasive, non-contact and \textit{in vivo} monitoring of blood glucose is a long needed pathology tool for saving patients from recurring pain and hassle that can accompany conventional blood glucose testing methods. Optical coherence tomography known for its high axial resolution imaging modality is adopted in this article for monitoring glucose levels in tissue like media non-invasively. Making use of changes in reduced scattering coefficient due to the refractive-index mismatch between the extracellular fluid and the cellular membranes and armed with a theoretical model, we establish a correlation between the glucose concentration and reduced scattering coefficient. The scattering coefficients are extracted ...
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Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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