1. Articles in category: NDE/NDT

    1-24 of 384 1 2 3 4 ... 14 15 16 »
    1. Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

      Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

      Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.

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    2. At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement Method

      At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement Method

      Optical Coherence Tomography (OCT) is a promising technology for monitoring of pharmaceutical coating processes. However, the pharmaceutical development and manufacturing require a periodic validation of the sensor’s accuracy. For this purpose, we propose polyethylene terephthalate (PET) films as a model system, which can be periodically measured during manufacturing coating monitoring via OCT. This study proposes a new approach addressing the method validation requirement in the pharmaceutical industry and presents results for complementary methods. The methods investigated include direct measurement of the layer thickness using a micrometer gauge as reference, X-ray micro computed tomography, transmission and reflectance terahertz pulsed imaging ...

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    3. Method to characterize cut gemstones using optical coherence tomography

      Method to characterize cut gemstones using optical coherence tomography

      The invention includes an improvement in a method of assessing a gemstone having at least one planar face with an internally reflecting surface including the steps of optically modifying the at least one planar face of the gemstone to return a sample beam from an internally reflecting plane corresponding to the at least one planar face to an optical coherence tomography (OCT) system; selectively directing the sample beam from an optical coherence tomography (OCT) system onto the gemstone; and generating an OCT image map of the gemstone to determine volume, gem carat weight and/or quality.

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    4. Assessing internal fouling during microfiltration optical coherence tomography and evapoporometry

      Assessing internal fouling during microfiltration optical coherence tomography and evapoporometry

      The internal fouling of membranes is typically presumed and inferred, but the direct characterization of representative samples is challenging. This study targeted to assess internal fouling using the Optical Coherence Tomography (OCT) and Evapoporometry (EP) techniques for real-time monitoring during filtration and off-line measurement of the pore size distributions (PSDs) of the fouled membranes, respectively. The results were validated by atomic force microscopy (AFM) measurements and also the three-mechanism fouling model. The foulant used was the well-studied bovine serum albumin (BSA), while the membranes were three commercially available polymeric microfiltration membranes with similar nominal pore sizes and porosities. Although the ...

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    5. 3D Fingerprint Gender Classification Using Deep Learning

      3D Fingerprint Gender Classification Using Deep Learning

      Optical Coherence Tomography (OCT) is a high resolution imaging technology, which provides a 3D representation of the fingertip skin. This paper for the first time investigates gender classification using those 3D fingerprints. Different with current fingerprint gender classification methods, the raw multiple longitudinal( X - Z ) fingertip images of one finger can be applied instead of studying features extracted from fingerprints, and the model can be trained effectively when the training data set is relatively small. Experimental results show that the best accuracy of 80.7% is achieved by classifying left fore finger on a small database with 59 persons. Meanwhile ...

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    6. Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      The success of reef-building corals for >200 million years has been dependent on the mutualistic interaction between the coral host and its photosynthetic endosymbiont dinoflagellates (family Symbiodiniaceae) that supply the coral host with nutrients and energy for growth and calcification. While multiple light scattering in coral tissue and skeleton significantly enhance the light microenvironment for Symbiodiniaceae, the mechanisms of light propagation in tissue and skeleton remain largely unknown due to a lack of technologies to measure the intrinsic optical properties of both compartments in live corals. Here we introduce ISOCT (inverse spectroscopic optical coherence tomography), a non-invasive approach to measure ...

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    7. New imaging platform examines mechanisms behind coral bleaching

      New imaging platform examines mechanisms behind coral bleaching

      As coral reefs deteriorate in the face of climate change, an interdisciplinary Northwestern Engineering research team has developed an innovative method to image coral nanoscale structures and quantify pigment absorption in live corals, an indicator of coral health. The imaging platform could become a valuable tool to help marine biologists better understand coral physiology as well measure and monitor coral health. Reef building corals provide a home to more than 1 million species in our oceans. Yet increasing ocean temperatures have given rise to coral bleaching, a phenomenon where corals expel their life-providing algae, jeopardizing the health and sustainability of ...

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    8. Electromagnetic analysis for optical coherence tomography based through silicon vias metrology

      Electromagnetic analysis for optical coherence tomography based through silicon vias metrology

      This paper reports on progress in the analysis of time-domain optical coherence tomography (OCT) applied to the dimensional metrology of through-silicon vias (TSVs), which are vertical interconnect accesses in silicon, enabling three-dimensional (3D) integration in microelectronics, and estimates the deviations from earlier, simpler models. The considered TSV structures are 1D trenches and circular holes etched into silicon with a large aspect ratio. As a prerequisite for a realistic modeling, we work with spectra obtained from reference interferograms measured at a planar substrate, which fully includes the dispersion of the OCT apparatus. Applying a rigorous modal approach, we estimate the differences ...

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    9. Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

      Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

      In this work a recently developed in-line measurement technique for monitoring of coating thickness was applied to a spray-coating process in a three-dimensional prismatic spouted bed. The layer thickness was quantified with an optical coherence tomography (OCT) sensor positioned in front of the observation window of the process chamber. The time-dependent layer thickness was measured directly and in real-time from the OCT images, with no chemometric calibration being needed. To validate the obtained data, additional off-line OCT measurements were performed with optical particle size measurements and micro–computed tomography (micro-CT). The off-line measurements were conducted with representative samples extracted at ...

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    10. Optical properties of human milk

      Optical properties of human milk

      With human milk being the most important source of infant nutrition, the protection and support of breastfeeding are essential from a global health perspective. Nevertheless, relatively few objective methods are available to investigate human milk composition and lactation physiology when a mother experiences breastfeeding problems. We argue that optics and photonics offer promising opportunities for this purpose. Any research activity within this new application field starts with a thorough understanding on how light interacts with human milk. Therefore, the aim of this study was to investigate the full set of optical properties for human milk and the biological variability therein ...

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    11. Optical coherence tomography in forensic sciences: a review of the literature

      Optical coherence tomography in forensic sciences: a review of the literature

      Optical coherence tomography (OCT) is an interferometric imaging technique that has revolutionized clinical ophthalmology since the first half of the 1990’s. Despite this approach being successfully employed in ophthalmology and having great potential in forensic cases, its use in different forensic fields appears to be quite limited. In this review we reviewed the scientific literature regarding the application of OCT in forensic science and legal medicine from 1995 to 2019. Our research showed the usefulness of this approach for the study of coronary injuries, postmortem ocular changes, forensic entomology, and several other applications of specific forensic interest (the study ...

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    12. Application of optical coherence tomography for improved in-situ flaw detection in nylon 12 selective laser sintering (Thesis)

      Application of optical coherence tomography for improved in-situ flaw detection in nylon 12 selective laser sintering (Thesis)

      Despite significant advances made since the inception of selective laser sintering (SLS), many of the same problems identified by early researchers including high part porosity, inadequate surface finish, and part strength uncertainty persist today. Because of these challenges, quality validation and improved process control continue to be identified as critical areas of improvement in industry roadmaps. To address these issues, an optical coherence tomography (OCT) sensor is investigated for feasibility of use in in-situ flaw detection in SLS. Benchtop OCT imaging of nylon in solid, liquid, and resolidified phases revealed subsurface imaging through liquid and resolidified nylon material was possible ...

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    13. How to Measure Coating Thickness of Tablets: Method Comparison of Optical Coherence Tomography, Near-infrared Spectroscopy and Weight-, Height- and Diameter Gain

      How to Measure Coating Thickness of Tablets: Method Comparison of Optical Coherence Tomography, Near-infrared Spectroscopy and Weight-, Height- and Diameter Gain

      Film coating of pharmaceutical dosage forms, such as tablets and pellets, can be used to tailor the drug release profile. With that regard, a uniform coating thickness of a single tablet (intra-tablet), all tablets (inter-tablet) and subsequent batches (inter-batch) is crucial. We present a method comparison between in-line (optical coherence tomography and near-infrared spectroscopy) and well-established off-line (height-, weight- and diameter-gain) approaches to determining the coating thickness of tablets. We used single tablets drawn during a commercial coating process. Comparing the low intra- and high inter-tablet coating variability indicated that the tablets had a broad distribution of spray zone passes ...

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    14. Laser cleaning of paintings: in situ optimization of operative parameters through non-invasive assessment by optical coherence tomography (OCT), reflection FT-IR spectroscopy and laser induced fluorescence spectroscopy (LIF)

      Laser cleaning of paintings: in situ optimization of operative parameters through non-invasive assessment by optical coherence tomography (OCT), reflection FT-IR spectroscopy and laser induced fluorescence spectroscopy (LIF)

      Nowadays the use of laser technology as a highly precise tool for the cleaning of paintings is gaining ground. The development of a non-invasive analytical protocol aimed at thorough assessment of the treated surfaces and real time monitoring of the laser cleaning action is thus becoming imperative. This ensures that no side effects (e.g. discoloration, darkening, blackening) will occur on the painting surfaces due to laser ablation. In the present study the potential of the combined use of optical coherence tomography (OCT) and reflection FT-IR spectroscopy for in situ non-invasive assessment of laser cleaning procedures has been investigated on ...

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    15. Developments in Contact Lens Imaging: New Applications of Optical Coherence Tomography

      Developments in Contact Lens Imaging: New Applications of Optical Coherence Tomography

      Optical coherence tomography (OCT) is a high-speed and non-contact optical imaging technology widely used for noninvasive cross-sectional imaging of biological objects. Two main OCT technologies have been developed: time domain and Fourier domain technologies. The latter can be further divided into spectral domain OCT, which uses a broadband light source and a spectrometer as a detector, and swept source OCT, which employs a quickly-rotating laser source. Advances in OCT technology have made it one of the most helpful devices in ophthalmic practice. Fourier OCT has revolutionized imaging of the posterior segment of the eye, as well as of anterior structures ...

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    16. Microscopic glass blowing used to make tiny optical lenses

      Microscopic glass blowing used to make tiny optical lenses

      Inserting air into hot glass to form a bubble has been used to make glass objects since Roman times. In new work, researchers apply these same glass blowing principles on a microscopic scale to make specialized miniature cone-shaped lenses known as axicons. Axicons are used to shape laser light in a way that is beneficial for optical drilling, imaging and creating optical traps for manipulating particles or cells. These lenses have been known for more than 60 years, but their fabrication, especially when small, is not easy. "Our technique has the potential of producing robust miniature axicons in glass at ...

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    17. Subsurface and Layer Intertwined Template Protection Using Inherent Properties of Full-Field Optical Coherence Tomography Fingerprint Imaging

      Subsurface and Layer Intertwined Template Protection Using Inherent Properties of Full-Field Optical Coherence Tomography Fingerprint Imaging

      The emergence of Full Field-Optical Coherence Tomography (FF-OCT) for fingerprint imaging has shown it’s ability in addressing and solving the drawbacks of traditional fingerprinting solutions such as spoofing attacks, low accuracy for abraded fingerprint. With the availability of multiple internal fingerprints (from subsurface captured at different depths), it is also essential to consider the aspects of ideal biometrics where the privacy of the fingerprint data is preserved. In this work, we propose a new framework for fingerprint template protection, highly customized to FF-OCT by exploring the interplay between subsurface. As a first of it’s kind work attempting template ...

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    18. 3D Printer Powered by Machine Vision and Artificial Intelligence

      3D Printer Powered by Machine Vision and Artificial Intelligence

      Objects made with 3D printing can be lighter, stronger, and more complex than those produced through traditional manufacturing methods. But several technical challenges must be overcome before 3D printing transforms the production of most devices. ADVERTISEMENT Commercially available printers generally offer only high-speed, high-precision, or high-quality materials. Rarely do they offer all three, limiting their usefulness as a manufacturing tool. Today, 3D printing is used mainly for prototyping and low-volume production of specialized parts. Now Inkbit, a startup out of MIT, is working to bring all of the benefits of 3D printing to a slew of products that have never ...

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      Mentions: Inkbit
    19. Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

      Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.

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      Mentions: Yalin Zheng
    20. Non-Invasive Morphological Characterization of Rice Leaf Bulliform and Aerenchyma Cellular Regions Using Low Coherence Interferometry

      Non-Invasive Morphological Characterization of Rice Leaf Bulliform and Aerenchyma Cellular Regions Using Low Coherence Interferometry

      Non-invasive investigation of rice leaf specimens to characterize the morphological formation and particular structural information that is beneficial for agricultural perspective was demonstrated using a low coherence interferometric method called swept source optical coherence tomography (SS-OCT). The acquired results non-invasively revealed morphological properties of rice leaf, such as bulliform cells; aerenchyma, parenchyma, and collenchyma layer; and vascular bundle. Beside aforementioned morphologic characteristics, several leaf characteristics associated with cytological mechanisms of leaf rolling (leaf inclination) were examined for the pre-identification of inevitable necrosis and atrophy of leaf tissues by evaluating acute angle information, such as angular characteristics of the external bi-directional ...

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    21. Comparison of laser triangulation, phase shift triangulation and swept source optical coherence Tomography for nondestructive inspection of objects with micrometric accuracy

      Comparison of laser triangulation, phase shift triangulation and swept source optical coherence Tomography for nondestructive inspection of objects with micrometric accuracy

      We compare the performance of laser triangulation, phase shift triangulation and swept source optical coherence tomography (SSOCT) for quantitative nondestructive inspection. Measurement accuracies of these three optical 3D imaging techniques can be reduced to a few tens of micrometers or less, making it possible to locate and geometrically characterize defects at the micrometric scale. We consider surfaces with different optical properties and we discuss the ability of these techniques to reconstruct the surface profiles. For opaque surfaces, the three techniques provide very similar results. For semi-transparent and transparent surfaces, the accuracy achieved by SSOCT relies on the capability of detecting ...

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    22. Terahertz continuous wave system using phase shift interferometry for measuring the thickness of sub-100-μm-thick samples without frequency sweep

      Terahertz continuous wave system using phase shift interferometry for measuring the thickness of sub-100-μm-thick samples without frequency sweep

      A terahertz continuous wave system is demonstrated for thickness measurement using Gouy phase shift interferometry without frequency sweep. One arm of the interferometer utilizes a collimated wave as a reference, and the other arm applies a focused beam for sample investigation. When the optical path difference (OPD) of the arms is zero, a destructive interference pattern is produced. Interference signal intensity changes induced by the OPD changes can be easily predicted by calculations. By minimizing the difference between the measured and the calculated signal against the OPD, the thicknesses of sub-100-μm-thick samples are determined at 625 GHz.

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    23. Sub-surface imaging of soiled cotton fabric using full-field optical coherence tomography

      Sub-surface imaging of soiled cotton fabric using full-field optical coherence tomography

      In the laundry industry, colorimetry is a common way to evaluate the stain removal efficiency of detergents and cleaning products. For ease of visualization, the soiling agent is treated with a dye before measurement. However, it effectively measures the dye removal rather than stain removal, and it cannot provide depth-resolved information of the sample. In this study, we show that full-field (FF) optical coherence tomography (OCT) technique is capable of measuring the cleaning effect on cotton fabric by imaging the sub-surface features of fabric samples. We used a broadband light-emitting diode (LED) source to power the FF-OCT system that achieves ...

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      Mentions: Yalin Zheng
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