1. Articles in category: Funding

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    1. University of California at San Francisco Receives NIH Grant for Infrared Methods for Lesion Activity Assessment

      University of California at San Francisco Receives NIH Grant for Infrared Methods for Lesion Activity Assessment

      University of California at San Francisco Receives a 2020 NIH Grant for $45,564 for Infrared Methods for Lesion Activity Assessment. The principal investigator is Nai-Yaun Chang. Below is a summary of the proposed work. The overall objective of this proposed research is to develop methods for the clinical assessment of lesion structure and activity. Improved imaging technologies employing non-ionizing radiation will significantly improve caries diagnosis and management. It is not sufficient to simply detect carious lesions, methods are needed to assess the activity of the lesion and determine if chemical intervention is needed. The central hypothesis underlying this proposal ...

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    2. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives a 2020 NIH Grant for $486,444 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Joseph Carroll. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of treating these devastating diseases is a formidable task. Nevertheless, trials examining novel therapeutic strategies are underway. An important key to success in the early phases of such trials is selection of patients with reasonable therapeutic potential – for example, a ...

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    3. University of Texas Health Science Center in Houston ReceivesNIH Grant for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis

      University of Texas Health Science Center in Houston ReceivesNIH Grant for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis

      University of Texas Health Science Center in Houston Receives a 2020 NIH Grant for $398,791 for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis. The principal investigator is Shervin Assassi. Below is a summary of the proposed work. Systemic sclerosis (SSc-scleroderma) is an autoimmune disease leading to widespread fibrosis in skin and internal organs. Skin involvement is a prominent source of distress and morbidity in this disease. The modified Rodnan skin score (mRSS) as the current gold standard for assessment of skin thickening has limited accuracy, high inter-observer variability, requires extensive training which have ...

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    4. University of Southern California Receives NIH Grant for Comb Light Source/Imaging Spectrometer for Advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives NIH Grant for Comb Light Source/Imaging Spectrometer for Advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives a 2020 NIH Grant for $239,351 for Comb Light Source/Imaging Spectrometer for Advanced Spectral Domain Optical Coherence Tomography. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There is a growing interest in the development of functional imaging with Optical Coherence Tomography (OCT). Many of these approaches to functional imaging rely on the exquisite phase sensitivity of the OCT interferometer. These include well established techniques like Doppler OCT for measuring blood flow as well as emerging applications like OCT elastography for measuring mechanical properties, and Magnetomotive OCT and ...

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    5. General Electric Receives NIH Grant for Multi-Scale 3-D Image Analytics for High Dimensional Spatial Mapping of Normal Tissue

      General Electric Receives NIH Grant for Multi-Scale 3-D Image Analytics for High Dimensional Spatial Mapping of Normal Tissue

      General Electric Receives a 2020 NIH Grant for $750,000 for Multi-Scale 3-D Image Analytics for High Dimensional Spatial Mapping of Normal Tissue. The principal investigator is Yousef Al-Kofahi. Below is a summary of the proposed work. The overall goal of the proposed project is to develop open-source software and algorithms for 3-D reconstruction and multi-scale mapping of normal tissues. Another significant goal is to evaluate effects of aging and environmental factors on molecular and structural architecture of skin. We will leverage our mature (TRL8) technology for multiplexed 2-D imaging (Cell DIVE™), and our vast experience in 2-D image analytics ...

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    6. PhotoniCare Announces More Than $7 Million in Funding for Commercial Expansion of First-In-Class Ear Imaging Technology

      PhotoniCare Announces More Than $7 Million in Funding for Commercial Expansion of First-In-Class Ear Imaging Technology

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced an oversubscribed $5.2 million Series A financing led by i2E Management Company Inc., with co-investment from OSF Ventures, Sony Innovation Fund, and Dreampact Ventures. The company also announced that it has received a $2.1 million Phase II Small Business Innovation Research ( SBIR ) grant from the National Institutes of Health ( NIH ). The competitive NIH SBIR program funds early-stage small businesses seeking to commercialize innovative biomedical technologies. In January, PhotoniCare announced that the U.S. Food and Drug Administration (FDA) had granted clearance ...

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    7. Johns Hopkins Receives NIH Grant for Enabling Technology for Image-Guided Robot-Assisted Sub-Retinal Injections.

      Johns Hopkins Receives NIH Grant for Enabling Technology for Image-Guided Robot-Assisted Sub-Retinal Injections.

      Johns Hopkins Receives a 2020 NIH Grant for $504,023 for Enabling Technology for Image-Guided Robot-Assisted Sub-Retinal Injections. The principal investigator is Iulian Iordachita. Below is a summary of the proposed work. The goal of this proposal is to design, develop and evaluate a novel clinically compatible surgical platform for enhancing the retina surgeon's ability to provide therapy to the subretinal domain. Efficient, safe, reproducible delivery methods would enable safe and precise delivery of stem cell, nanoparticle and gene therapies for prevalent ocular diseases including but not limited to Age-related Macular Degeneration (AMD). The proposed cooperative surgical robot utilizes ...

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    8. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2020 NIH Grant for $299,643 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease. The principal investigator is Danny Wang. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are inaccessible to existing imaging technologies. Characteristic parenchymal lesions on MRI ...

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    9. Massachusetts General Hospital Receives NIH Grant for Volumetric Optical Coherence Tomography of Human Cerebellar Circuitry

      Massachusetts General Hospital Receives NIH Grant for Volumetric Optical Coherence Tomography of Human Cerebellar Circuitry

      Massachusetts General Hospital Receives a 2020 NIH Grant for $248,993 for Volumetric Optical Coherence Tomography of Human Cerebellar Circuitry. The principal investigator is Hui Wang. Below is a summary of the proposed work. The goal in seeking a K99/R00 Pathway to Independence Award is to establish myself as an independent principal investigator to study the structural-functional relationship of the brain circuitry in normal and brain disorders. The proposed project, driven by the need for understanding the human brain with high-resolution high-throughput tools and my extensive experience in biomedical optics for neuroimaging, aims to establish a versatile tool to ...

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    10. University of Maryland Receives NIH Grant for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI

      University of Maryland Receives NIH Grant for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI

      University of Maryland Receives a 2020 NIH Grant for $609,639 for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI. The principal investigator is Daniel Harrison. Below is a summary of the proposed work. Although MRI is the major diagnostic and prognostic tool used in the care of patients with multiple sclerosis (MS), many aspects of MS pathology are still not well visualized. Recent histopathologic studies in MS have shed light on a previously unrecognized phenomenon without a proven MRI correlate- meningeal inflammation. Pathologic data suggests that meningeal inflammation in MS ...

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    11. Massachusetts General Hospital Receives NIH Grant for Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2020 NIH Grant for $420,000 for Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. Below is a summary of the proposed work. Recent progress in the Center for Biomedical OCT Research and Translation has resulted in 1) the ability to detect and map polarimetric signatures for tissue characterization, and 2) fast and effective methods for quantitative angiographic imaging with microscopic resolution over fields of view as large as 10’s of cubic centimeters. Motivated by recent insights from autopsy and clinical studies of Alzheimer’s disease patients, we seek ...

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    12. Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption

      Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption

      Northwestern University Receives a 2020 NIH Grant for $516,102 for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption. The principal investigator is Hao Zhang. Below is a summary of the proposed work. Our long-term goal is to develop new functional extensions of optical coherence tomography (vis-OCT) for clinical diagnosis and management of glaucoma. Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) and optic nerve defects and atrophy, afflicting more than 60 million people worldwide. It is often develops slowly with symptoms and damage that are not noticed at early stage. Caring for those ...

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    13. Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT Evolution to Reveal Early-Stage Changes in Glaucoma

      Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT Evolution to Reveal Early-Stage Changes in Glaucoma

      Legacy Emanuel Hospital and Health Center Receives a 2020 NIH Grant for $543,351 for Advancing OCT Evolution to Reveal Early-Stage Chalnges in Glaucoma. The principal investigator is Brad Fortune. Below is a summary of the proposed work. Currently, diagnosis of glaucoma and patient management decisions are often informed by thinning of the optic nerve head (ONH) neuro-retinal rim, peripapillary retinal nerve fiber layer (RNFL), and macular inner retinal layers, as detected using optical coherence tomography (OCT). These measurements are useful because they are predictive of subsequent visual field decline, and of faster rates of subsequent thinning. However, by the ...

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    14. Duke University Receives a 2020 NIH Grant for $195,750 for High Speed, Motion-Stabilized, Handheld OCT for Pediatric Imaging

      Duke University Receives a 2020 NIH Grant for $195,750 for High Speed, Motion-Stabilized, Handheld OCT for Pediatric Imaging

      Duke University Receives a 2020 NIH Grant for $195,750 for High Speed, Motion-Stabilized, Handheld OCT for Pediatric Imaging. The principal investigator is Joeseph Izatt. Below is a summary of the proposed work. In pre-term infants the development of the retina and retinal vasculature is incomplete at birth and progresses rapidly during the infant’s first few months of life. Many pediatric retinal diseases, including retinopathy of prematurity (ROP), have a vascular etiology and are caused by mal-development of retinal vasculature during this period of rapid growth. Preterm infants at risk for ROP make up 1.4% of the newborn ...

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    15. Physical Sciences Incorporated Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Incorporated Receives a 2020 NIH Grant for $672,2387 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as ...

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    16. Massachusetts General Hospital Receives NIH Grant for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives a 2020 NIH Grant for $179,280 for Low Risk In Vivo Diagnosis of IPF with Optical Imaging. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, ultimately fatal form of idiopathic interstitial pneumonitis (IIP), with a 3 year survival rate of 0%. Diagnostic certainty of IPF is critical to patient management and therapeutic decision-making. Two new FDA-approved therapies, pirfenidone and nintedanib, have been shown to slow disease progression in IPF and brought new hope to IPF patients. Due to their high costs, side ...

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    17. UCSD Receives NIH Grant for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

      UCSD Receives NIH Grant for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

      University of California at San Diego Receives a 2020 NIH Grant for $117,347 for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography. The principal investigator is Mark Christopher. Below is a summary of the proposed work. Primary open angle glaucoma (POAG) is a leading cause of blindness in the United States and worldwide. It is estimated that over 2.2 million Americans suffer from POAG and that over 130,000 are legally blind from the disease. As the population ages, the number of people with POAG in the United States will increase ...

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    18. Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2020 NIH Grant for $187,546 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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    19. Oregon Health & Science University Receives NIH Grant for Optical Coherence Tomography Differential Diagnosis and Treatment of Irregular Corneas

      Oregon Health & Science University Receives NIH Grant for Optical Coherence Tomography Differential Diagnosis and Treatment of Irregular Corneas

      To see well, the cornea must maintain near perfect clarity and shape. Several disease processes can distort corneal shape and degrade vision. These include ectasia/keratoconus (stromal thinning and bulging), primary epithelial deformation (contact lens-related warpage, dry eye, epithelial basement membrane dystrophy), and stromal changes (scar, stromal dystrophy, surgery). Some of these conditions can appear similar on standard anterior topography and yet require very different treatments. Therefore a goal of this project is to use optical coherence tomography (OCT), a 3-dimensional imaging technology with micrometer-level resolution, to differentiate between different types of corneal shape irregularities. The unique ability of OCT ...

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    20. Fred Hutchinson Cancer Research Center Receives NIH Grant for Biologic Correlatives of Chronic GVHD Onset

      Fred Hutchinson Cancer Research Center Receives NIH Grant for Biologic Correlatives of Chronic GVHD Onset

      Fred Hutchinson Cancer Research Center Receives a 2020 NIH Grant for $112,530 for Biologic Correlatives of Chronic GVHD Onset. The principal investigator is Stephanie Lee. Below is a summary of the proposed work. Allogeneic hematopoietic cell transplantation (HCT) can cure many hematologic cancers and other life- threatening hematologic diseases, but 20-50% of survivors develop chronic graft-versus-host disease (cGVHD), the leading cause of morbidity and mortality in transplant survivors. In cGVHD, the donor's immune cells attack the patient setting up a cascade of events resulting in a pleomorphic multi-organ syndrome reminiscent of autoimmune diseases such as systemic sclerosis, systemic ...

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    21. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives a 2020 NIH Grant for $564,228 for Functional and Structural Optical Coherence Tomography for Glaucoma. The principal investigator is David Huang. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnosis and close monitoring of glaucoma are important because the onset is insidious and the damage is irreversible. Advanced imaging modalities such as optical coherence tomography (OCT) have been used in the past 2 decades to improve the objective evaluation of glaucoma. OCT has higher axial spatial resolution than other posterior eye imaging modalities and can precisely ...

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    22. Massachusetts General Hospital Receives NIH Grant for Quantitative Biomechanics Imaging

      Massachusetts General Hospital Receives NIH Grant for Quantitative Biomechanics Imaging

      Massachusetts General Hospital Receives a 2020 NIH Grant for $340,916 for Quantitative Biomechanics Imaging. The principal investigator is Seok-Hyun Andy Yun. Below is a summary of the proposed work. TRD 1 The proposed research in TRD Project 1 is to develop novel optical coherence tomography (OCT)-based techniques and tools for measuring the mechanical properties and parameters as well as acoustic transduction in tissues. The focus on tissue biomechanics responds to the emerging opportunity to harness OCT's unique capabilities to obtain quantitative maps of tissue vibration, deformation, strain, and force at high precision and high spatiotemporal resolution. Specific ...

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    23. Massachusetts General Hospital Receives NIH Grant for Percutaneous and Interstitial Imaging

      Massachusetts General Hospital Receives NIH Grant for Percutaneous and Interstitial Imaging

      Massachusetts General Hospital Receives a 2020 NIH Grant for $317,085 for Percutaneous and Interstitial Imaging. The principal investigator is Martin Villiger. Below is a summary of the proposed work. TRD 3 The overall goal of TRD 3 is to enable advanced OCT imaging, with high resolution and functional and dynamic contrast, inside the living body, through narrow diameter, rotational probes. Instruments and algorithms will be developed that overcome fundamental barriers, intrinsic to flexible, rotational fiber-optic probes, that have previously compromised image quality and prohibited the integration of functional and dynamic contrast. Specific Aim 1 addresses the need for functional ...

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    24. Massachusetts General Hospital Receives NIH Grant for Functional Imaging

      Massachusetts General Hospital Receives NIH Grant for Functional Imaging

      Massachusetts General Hospital Receives a 2020 NIH Grant for $338,401 for Functional Imaging. The principal investigator is Benjamin Vakoc. Below is a summary of the proposed work. TRD 2 TRD project 2 will develop novel optical coherence tomography (OCT) technologies to address unmet needs in the functional imaging of tissue. Specific Aim #1 addresses the need for high-speed and high- resolution angiographic imaging systems for preclinical research. A new high-speed optical architecture for high-resolution optical coherence microscopy (OCM) will be constructed that is 100 times faster than existing OCM instrumentation. These improvements in speed will be leveraged to expand ...

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