1. Articles in category: Funding

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    1. Baylor College of Medicine Receives a 2020 NIH Grant for Biomechanics of Early Mammalian Cardiogenesis

      Baylor College of Medicine Receives a 2020 NIH Grant for Biomechanics of Early Mammalian Cardiogenesis

      Baylor College of Medicine Receives a 2020 NIH Grant for $554,542 for Biomechanics of Early Mammalian Cardiogenesis. The principal investigator is Irina Larina. Below is a summary of the proposed work. Human congenital heart defects (CHD) are very common, occurring in nearly 1% of live births. Moreover, cardiovascular (CV) failures are the leading cause of birth defect- related deaths in infants. It is well established that biomechanical stimuli are important regulators of CV development. Thus, defining how mechanical factors are integrated with genetic pathways to coordinate mammalian heart tube function and morphogenesis is critically important for understanding CHD and ...

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    2. University of Houston Receives a 2020 NIH Grant for Biomechanics of Neural Tube Development using Brillouin-OCT Multimodality

      University of Houston Receives a 2020 NIH Grant for Biomechanics of Neural Tube Development using Brillouin-OCT Multimodality

      University of Houston Receives a 2020 NIH Grant for $633,348 for Biomechanics of Neural Tube Development using Brillouin-OCT Multimodality. The principal investigator is Kirill Larin. Below is a summary of the proposed work. The objective of this proposal is to develop a non-contact, all-optical imaging technology to map elastic moduli and forces involved in critical aspects of embryonic development with high 3D resolution. The proposed technology is based on combined Brillouin spectroscopy and Optical Coherence Tomography (OCT), which will be used to gain fundamental understanding of biomechanical factors involved during neural tube closure (NTC) in normal and pathological cases ...

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    3. Oregon Health and Sciences University Receives a 2020 NIH Grant for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity

      Oregon Health and Sciences University Receives a 2020 NIH Grant  for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity

      Oregon Health and Sciences University Receives a 2020 NIH Grant for $341,800 for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity. The principal investigator is Yifan Jian. Below is a summary of the proposed work. The long-term goal of this project is to determine whether optical coherence tomography (OCT) and OCT angiography (OCTA) might lead more accurate and objective diagnosis, earlier intervention, and improved outcomes in retinopathy of prematurity (ROP). International consensus and National Institute of Health (NIH) funded clinical trials over the last 30 years have defined the phenotypic classifications, natural history, prognosis, and management ...

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    4. UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology

      UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology

      University of California at Irvine Receives a 2020 NIH Grant for $593,557 for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Each year, 50M Americans suffer from chronic rhinosinusitis (CRS) and allergic rhinitis (AR). The economic impact accounts for over $35B/year in health care expenditures alone, with over 3.5M work and 2M school days lost each year. Accordingly, over 600K operations per year are performed to treat sinonasal disease. The disease burden is immense with a profound ...

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    5. UC Irvine Receives a 2020 NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      UC Irvine Receives a 2020 NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California at Irvine Receives a 2020 NIH Grant for $698,188 for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Cardiovascular disease is responsible for 1 in 4 deaths, or 650,000 Americans, every year. It is the leading cause of death in the United States. Ruptured atherosclerotic plaques are the main cause of acute coronary events, and it is of lethal consequence. Clinically, early detection of the latent vulnerability of plaques is the first line of defense against such deadly circumstances, and ...

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    6. Lumedica Incorporated Receives a 2020 NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Incorporated Receives a 2020 NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Incorporated Receives a 2020 NIH Grant for $499,919 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system suitable for diagnostic retinal imaging at the point of care. The target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systems. By breaking the $15,000 system barrier we ...

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    7. Case Western Reserve University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western Reserve University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western Reserve University Receives a 2020 NIH Grant for $727,994 for Computer Assisted Coronary Artery Stent Interventions The principal investigator is David Wilson. Below is a summary of the proposed work. Computer assisted coronary artery stent interventions Summary When treating highly calcified coronary artery lesions with stents, interventional cardiologists, with limited information, make stressful treatment decisions, which can lead to inadequate stent deployment and poor outcomes, or even rare calamitous events. When calcification is present, a cardiologist must choose to use a normal sized angioplasty balloon; a larger angioplasty balloon with increasingly high, prolonged pressures to fracture the ...

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    8. Massachusetts General Hospital Receives NIH Grant for Blood Flow-Based Guidance and Diagnostics Using OCT

      Massachusetts General Hospital Receives NIH Grant for Blood Flow-Based Guidance and Diagnostics Using OCT

      Massachusetts General Hospital Receives a 2020 NIH Grant for $174,174 for Blood Flow-Based Guidance and Diagnostics Using OCT. The principal investigator is Nestor Uribe-Patarroyo. Below is a summary of the proposed work. Diseases diagnosed with assessment of blood flow account for 29% of deaths in the US and are leading causes of premature morbidity, including visual disorders which carry an economic burden of $35 bil- lion per year. The heart disease with the most impact on public health is coronary artery disease (CAD); more than one million percutaneous coronary interventions (PCI) are performed in the US ev- ery year ...

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    9. University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy

      University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy

      University of Washington Receives a 2020 NIH Grant for $575,178 for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy. The principal investigator is Ruikang Wang. Below is a summary of the proposed work. The increasing incidence of diabetes in the US population and the inertial wave of aging in Americans will ensure that diabetic retinopathy (DR) remains one of the principal threats to the sight of adult patients and a significant management challenge for the clinical community. It is now clear that the peripheral retina is the site of pathology in many vision-threatening eye diseases, including ...

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    10. Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives a 2020 NIH Grant for $560,406 for Noninvasive Assessment of the Cornea by Diffusion OCT. The principal investigator is Andrew Rollins. Below is a summary of the proposed work. Keratoconus is a degenerative disease of the cornea that is a major cause of reduced vision-related quality of life in the United States, often leading to corneal transplantation. Ectasia after refractive surgery is a vision-threatening complication that can occur in apparently low-risk patients despite current screening technology. The biomechanical properties of the cornea play a central role in these diseases, but diagnostics are still rooted ...

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    11. National Jewish Health Receives NIH Grant for Role of Lung MSDC in Emphysema

      National Jewish Health Receives NIH Grant for Role of Lung MSDC in Emphysema

      National Jewish Health Receives a 2020 NIH Grant for $616,754 for Role of Lung MSDC in Emphysema. The principal investigator is Susan Majka. Below is a summary of the proposed work. Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality in the United States. COPD often is exacerbated by vasculopathy, which substantially worsens prognosis and limits survival. Vasculopathy is characterized by remodeling and loss of microvessels. Recent evidence has also highlighted a role for the alterations to the microvasculature during the early pathogenesis and heterogeneity of COPD, although the underlying mechanisms are not defined. The goal ...

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    12. Duke University Receives NIH Grant for Portable Motion-Stabilized Optical Coherence Tomography for Eye Care in Acute Care Settings

      Duke University Receives NIH Grant for Portable Motion-Stabilized Optical Coherence Tomography for Eye Care in Acute Care Settings

      Duke University Receives a 2020 NIH Grant for $400,789 for Portable Motion-Stabilized Optical Coherence Tomography for Eye Care in Acute Care Settings. The principal investigator is Anthony Kuo. Below is a summary of the proposed work. This research proposal from a multi-disciplinary team including an emergency medicine physician, ophthalmologists, and biomedical engineers seeks to improve the ability of acute care providers to diagnose and triage eye pathology at the point of care. Acute care settings such as emergency departments frequently take care of patients seeking eye care. In these acute care settings, standard of care instruments to examine the ...

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    13. University of Wisconsin Receives NIH Grant for The Interactions Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin Receives NIH Grant for The Interactions Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin Receives a 2020 NIH Grant for $368,084 for The Interactions Between Vocal Fold Hydration and Vibratory Biomechanics. The principal investigator is Jack Jiang. Below is a summary of the proposed work. Voice disorders affect millions of people worldwide. Patients have reported many negative social economic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and inflammation. The results of these disturbances can lead to ...

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    14. Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery.

      Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery.

      Duke University Receives a 2020 NIH Grant for $754,700 for Intraoperative OCT Guidance of Intraocular Surgery. The principal investigator is Joseph Izatt. Below is a summary of the proposed work. This is a resubmission application for a Bioengineering Research Partnership (BRP) which brings together a highly collaborative and experienced team of engineers and ophthalmic surgeons to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon’s current stereo microscopic view of ocular structures by continuing to integrate optical coherence tomography (OCT) technology, which is already well accepted in ophthalmic practice ...

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    15. Massachusetts General Hospital Receives NIH Grant for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy Response Assessment

      Massachusetts General Hospital Receives NIH Grant for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy Response Assessment

      Massachusetts General Hospital Receives a 2020 NIH Grant for $848,987 for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy Response Assessment. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal form of interstitial lung disease (ILD), affecting 100,000 per year in the US, with a 3-year survival rate of 50% and a large socio-economic healthcare burden. Early, accurate diagnosis is essential to determine treatment, which differs drastically between IPF and other ILDs. Initiating treatment as early as possible is a key strategy to prevent ...

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    16. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dynamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dynamics

      University of Washington Receives a 2020 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dynamics. The principal investigator is Tueng Shen. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not been a topic of major research interest. Topography, tonometry ...

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    17. Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives a 2020 NIH Grant for $188,771for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation. The principal investigator is Joseph Izatt. Below is a summary of the proposed work. This is an application for an Exploratory/Developmental Research Grant which brings together a team of experts in ophthalmic imaging, surgery and robotics to advance the state of the art in image-guided robotic microsurgical intervention. Corneal transplants are one of the most commonly performed allograft procedures worldwide, although there remains a substantial risk of immune rejection or graft failure. An alternative form of corneal transplantation ...

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    18. LighTopTech Corp. Receives Small Business Innovation Research Phase II Award from the US National Institutes of Health (NIH)

      LighTopTech Corp. Receives Small Business Innovation Research Phase II Award from the US National Institutes of Health (NIH)

      LighTopTech Corp., an upstate New York-based company building innovative optical instruments to bring to market disruptive imaging technologies industrial and medical fields, has been awarded a Phase II Small Business Innovation Research (SBIR) award by the National Eye Institute of the National Institutes of Health (NIH). The NIH Phase II award will allow LighTopTech to develop the first 3D high-definition imaging instrument based on Gabor-Domain Optical Coherence Microscopy (GDOCM) for quantitative assessment of corneal tissue at eye banks. LighTopTech will develop and apply machine learning methods to automatically segment the endothelial cells of the cornea and count them to assess ...

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    19. Perimeter Medical Imaging Receives $7.44 Million CPRIT Grant To Further Develop AI ImgAssist Technology at Leading Cancer Centers in Texas

      Perimeter Medical Imaging Receives $7.44 Million CPRIT Grant To Further Develop AI ImgAssist Technology at Leading Cancer Centers in Texas

      Perimeter Medical Imaging , a medical device company, today announces that it has received a $7.44 million grant from CPRIT, a leading state body funding cancer research, to continue developing its artificial intelligence technology that can help surgeons identify if cancer is still present post-tumor removal surgery. The sponsored technology, known as OTIS™, is designed to provide real-time information during breast cancer surgery. The platform’s ability to deliver ultra-high resolution and sub-surface image volumes across the surface of the removed tissue allows surgeons to assess if they have achieved the successful removal of the entire tumor. Should a surgeon ...

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    20. NinePoint Medical Receives NIH Grant for AI Computer Aided Diagnosis (CAD) Algorithm for Identification of Dysplasia in Patients with Barrett Esophagus

      NinePoint Medical Receives NIH Grant for AI Computer Aided Diagnosis (CAD) Algorithm for Identification of Dysplasia in Patients with Barrett Esophagus

      NinePoint Medical Receives a 2020 NIH Grant for $852,440 for AI Computer Aided Diagnosis (CAD) Algorithm for Identification of dysplasia in Patients with Barrett Esophagus. The principal investigator is Eman Namati. Below is a summary of the proposed work. The goal of this project is to develop a based computer aided diagnosis (CAD) algorithm for identification of regions at risk for developing esophageal adenocarcinoma (EAC) in optical coherence tomography (OCT) scans of the esophagus. EAC is one of the deadliest cancers with a 5-year survival rate of less than 20%; yet the standard of care for detecting precursors to ...

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    21. Florida International University Receives NIH Grant for Imaging the Functional Biomarkers of Photoreceptors

      Florida International University Receives NIH Grant for Imaging the Functional Biomarkers of Photoreceptors

      Florida International University Receives a 2020 NIH Grant for $485,580 for Imaging the Functional Biomarkers of Photoreceptors. The principal investigator is Shuliang Jiao. Below is a summary of the proposed work. Vision is the most fundamental of our senses and it is perhaps the greatest tragedy of all when blindness robs us of this modality”. Photoreceptors are light-detecting cells initiating vision. Loss of photoreceptor leads to loss of vision. This happens in millions of Americans with hereditary retinal degenerations or age-related macular degeneration (AMD). Loss of vision is not only a personal tragedy but also a burden to the ...

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    22. Johns Hopkins University Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosi

      Johns Hopkins University Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosi

      Johns Hopkins University Receives a 2020 NIH Grant for $585,102 for Imaging Neurodegeneration in Multiple Sclerosis. The principal investigator is Peter Calabresi. Below is a summary of the proposed work. One of the significant challenges facing treatment of people with multiple sclerosis (MS) is determining their individual likelihood of progression, as this information would significantly influence the type of therapy selected. Thus, developing specific tools to monitor and predict progression is critical to better manage patient care and to understand mechanisms of disease. We have been developing a multi-faceted approach to more readily monitor (through imaging) and predict (through ...

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    23. Indiana University Receives NIH Grant for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells

      Indiana University Receives NIH Grant for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells

      Indiana University Receives a 2020 NIH Grant for $409,668 for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells. The principal investigator is Donald Miller. Below is a summary of the proposed work. Ganglion cells (GCs) and other inner retinal neurons are fundamental to retinal neural circuitry, processing photoreceptor signals relayed from intermediate neurons for transmission to the brain. Yet, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. GCs in particular are lost to neurodegenerative disorders such as glaucoma, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We also know ...

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    24. University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging.

      University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging.

      University of Houston Receives a 2020 NIH Grant for $757,340 for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging. The principal investigator is David Mayerich. Below is a summary of the proposed work. The ability to correlate between large-scale developmental milestones and micro-scale cellular and protein- specific changes is a significant unmet need in the study of developmental biology. The overall objective of this work is to develop a multi-modality imaging platform that can provide time resolved three-dimensional images of tissue development, with high temporal and spatial resolutions at a molecular level. Current studies rely on ...

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