1. Articles in category: Funding

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    1. Case Western Reserve University Receives NIH Grant for Investigating Optical Pacing of the Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Investigating Optical Pacing of the Embryonic Heart

      Case Western Reserve University Received a 2013 NIH Grant for $176,625 for Investigating Optical Pacing of the Embryonic Heart. The principal investigator is Michael Jenkins. The program started in 2012 and ends in 2014. Below is a summary of the proposed work. Our long-term objective is to determine the influence biophysical forces have on heart development and how alterations of these forces early in development can lead to congenital heart defects (CHDs). CHDs are extremely prevalent affecting almost 36,000 newborns in the US each year, or 9 out of 1,000 live births. In order to tease apart ...

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    2. University of Arizona Receives NIH Grant for Diagnosis of Ovarian Cancer by Confocal Microendoscopy.

      University of Arizona Receives NIH Grant for Diagnosis of Ovarian Cancer by Confocal Microendoscopy.

      University of Arizona Received a 2013 NIH Grant for $65,063 for Diagnosis of Ovarian Cancer by Confocal Microendoscopy. The principal investigator is Arthur Gmitro. The program started in 2005 and ends in 2014. Below is a summary of the proposed work. The objective of this research is to further develop and clinically validate a real-time multispectral confocal microendoscope for in vivo diagnosis of ovarian cancer. The confocal microendoscope is a new type of instrument for visualizing tissue at the cellular level and has shown great promise for performing optical biopsy. Confocal microendoscopy has the potential to provide a physician ...

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    3. University of California at Irvine Receives NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      University of California at Irvine Receives NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      University of California at Irvine Received a 2013 NIH Grant for $123,249 for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT. The principal investigator is Jun Zhang. The program started in 2011 and ends in 2016. Below is a summary of the proposed work. There are approximately 20-40 million people in the United States with sleep apnea. The majority of them are undiagnosed and untreated at this time. Sleep apnea can lead to severe health complications including hypertension, heart failure, memory impairment, motor vehicle and work accidents, decreased work productivity, and increased risk of death. The ...

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    4. University of Pittsburgh Receives NIH Grant for Microsurgical In-Situ Image Guidance With Optical Coherence Tomography

      University of Pittsburgh Receives NIH Grant for Microsurgical In-Situ Image Guidance With Optical Coherence Tomography

      University of Pittsburgh Receives 2013 NIH Grant for $501,440 Microsurgical In-Situ Image Guidance With Optical Coherence Tomography. The principal investigator is George Stetten. The program started in 2011 and ends in 2015. Below is a summary of the proposed work. Over the past eight years of continuous funding by NIH, our laboratory has developed the concept of in-situ image guidance, which permits a real-time tomographic scan to be displayed as a virtual image within the patient, superimposed on the clinician's direct view of hands, tools, and target. One result has been a new ultrasound device, the Sonic Flashlight ...

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    5. Duke University Receives NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health

      Duke University Receives NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health

      Duke University Received a 2013 NIH Grant for $410,399 for Novel Determination of Microbicide PK in Women's Reproductive Health. The principal investigator is David Katz. The program started in 2012 and ends in 2016. Below is a summary of the proposed work. Vaginal microbicides offer much promise to prevent sexual transmission of HIV. The pharmacokinetics (PK) of a product (active pharmaceutical ingredient + dosage form) is central to prophylactic functionality (PD). But our ability to measure and predict microbicide PK is currently limited. Further, microbicide PD depends on how product + dosage regimen accommodate a range of conditions of the ...

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    6. MGH Receives 2013 NIH Grant for Development of a Preclinical Optical Frequency Domain Angiography Instrument

      MGH Receives 2013 NIH Grant for Development of a Preclinical Optical Frequency Domain Angiography Instrument

      MGH Receives 2013 NIH Grant for $204,038 for Development of a Preclinical Optical Frequency Domain Angiography Instrument. The principal investigator is Benjamin Vakoc. The program is part is a one year project. Below is a summary of the work. The National Institute on Deafness and Other Communication Disorders (NIDCD) supports research and development of innovative technologies for improving the quality and use of hearing aid devices. Physical Optics Corporation (POC) proposes the development of a new Ear Canal Optical Coherent Tomography (ECOCT) system to obtain the shape of the individual ear canal and the corresponding 3D image of the ...

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    7. Physical Optics Corporation Receives 2013 NIH Grant for Ear Canal Optical Coherence Tomography System

      Physical Optics Corporation Receives 2013 NIH Grant for Ear Canal Optical Coherence Tomography System

      Physical Optics Corporation Receives 2013 NIH Grant for $682,804 for Ear Canal Optical Coherence Tomography System. The principal investigator is Paul Shnitser. The program is part of a multiyear program that started in 2010 and ends in 2014. Below is a summary of the work. The National Institute on Deafness and Other Communication Disorders (NIDCD) supports research and development of innovative technologies for improving the quality and use of hearing aid devices. Physical Optics Corporation (POC) proposes the development of a new Ear Canal Optical Coherent Tomography (ECOCT) system to obtain the shape of the individual ear canal and ...

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    8. Oregon Health and Science University Receives 2013 NIH Grant for Studies in Glaucomatous Optic Nerve Damange

      Oregon Health and Science University Receives 2013 NIH Grant for Studies in Glaucomatous Optic Nerve Damange

      Oregon Health and Science University Receive a 2013 NIH Grant for $648,783 for Studies in Glaucomatous Optic Nerve Damange. The principal investigator is John Morrison. The program is part of a multiyear program that started in 1993 and ends in 2018.  Below is a summary of the work. Understanding cellular mechanisms of axonal injury from elevated intraocular pressure (IOP) is essential for developing glaucoma treatments that will protect the optic nerve. We have determined that an 8- hour exposure to Controlled Elevation of IOP (CEI) in anesthetized rats will reproduce optic nerve injury and gene expression changes within the ...

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    9. National Research Council Canada Receives a 2013 NIH Grant for Validating OCT and Raman Spectroscopy for Assessment of Tooth De/Remineralization

      National Research Council Canada Receives a 2013 NIH Grant for Validating OCT and Raman Spectroscopy for Assessment of Tooth De/Remineralization

      National Research Council Canada Receives a 2013 NIH Grant for $245,305 for Validating OCT and Raman Spectroscopy for Assessment of Tooth De/Remineralization. The principal investigator is Lin-P'ing Choo-Smith. The program is part of a multiyear program that started in 2006 and ends in 2017. Below is a summary of the work. Dental caries continues to be prevalent in children and youth, with significant oral health disparities existing in some population groups. This disease arises when the balance between pathological factors (e.g. cariogenic bacteria) and protective factors (e.g. saliva flow) is tipped in favour of demineralization ...

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    10. Johns Hopkins University Receives 2013 NIH Grant for Imaging Neurodegeneration in Multiple Sclerosis

      Johns Hopkins University Receives 2013 NIH Grant for Imaging Neurodegeneration in Multiple Sclerosis

      Johns Hopkins University Receives 2013 NIH Grant for $438,855 Imaging Neurodegeneration in Multiple Sclerosis. The principal investigator is Peter Calabresi. The program is part of a multiyear program that started in 2013 and ends in 2018. Below is a summary of the work. There is emerging evidence that gray matter (GM) degeneration is common in multiple sclerosis (MS), and more closely linked with disability than white matter (WM) injury. Indeed, WM volumes, as measured by high resolution MRI, wax and wane as a reflection of inflammation, whereas GM atrophy accelerates with time in MS. Whether GM degeneration purely results ...

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    11. Texas A&M University Receives NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research

      Texas A&M University Receives NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research

      Texas A&M University Received a 2013 NIH Grant for $294,979 Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research. The principal investigator is Brian E. Applegate. The program is part of a multiyear program that started in 2012 and ends in 2017. Below is a summary of the work. Atherosclerosis is the leading cause of morbidity and mortality in the United States and is characterized as a systemic, progressive disease process in which the arterial wall thickens through a process of inflammation, oxidative stress, and dyslipidemia. This process leads to plaque formation and flow limitation in the ...

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    12. NinePoint Medical Raises $10M in Equity Capital From Hercules Technology Growth Captial

      NinePoint Medical Raises $10M in Equity Capital From Hercules Technology Growth Captial

      Hercules Technology Growth Capital, Inc. (NYSE: HTGC), (“Hercules”), the leading specialty finance company focused on providing senior secured loans to venture capital-backed companies in technology-related markets, including technology, biotechnology, life science and cleantech industries, at all stages of development, today announced its first quarter 2013 portfolio update. $10.0 million commitment to NinePoint Medical , a medical device company using a platform technology called Nvision VLE, a non-invasive, endo-microscopic 3-D imaging solution.

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    13. Imaging Tech Could Lower Heart Disease Deaths

      Imaging Tech Could Lower Heart Disease Deaths

       Under a two-year, $498,325 Small Business Innovation Research (SBIR) Phase II National Science Foundation grant, Wasatch Photonics Inc. will continue the development of its intravascular optical coherence tomography technique, which shows where lesions and plaques have formed. Physicians can use these images to determine the best course of action, and to resolve issues such as stent placement. The technology will provide a new tool to identify and treat coronary artery disease, which “affects an estimated 16 million Americans and is a primary cause of heart attacks and strokes,” said William J. Brown, vice president of business development. “Identifying and ...

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    14. Imaging technology could lower coronary disease mortality rate

      Imaging technology could lower coronary disease mortality rate

      Wasatch Photonics Press Release - Patients undergoing angioplasty or other heart-related medical procedures could benefit from a new technology being developed with funding from the National Science Foundation (NSF). Optical imaging technology from Wasatch Photonics Inc. creates images of coronary artery walls in vivo to show where lesions and plaques have formed. Physicians can use the images to determine the best course of action, including where a stent might be placed. William J. Brown, vice president of business development at Wasatch Photonics, said the outcome of developing the technology will be the availability of a new tool to identify and treat ...

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    15. OCT Medical Imaging Incorporated receives NIH Grant for Development of a 3D Real-Time Imaging System for Subglottic Stenosis

      OCT Medical Imaging Incorporated receives NIH Grant for Development of a 3D Real-Time Imaging System for Subglottic Stenosis

      OCT Medical Imaging Incorporated received a $308,509 2013 NIH grant for Development of a 3D Real-Time Imaging System for Subglottic Stenosis. The principal investigator is Tirunelveli Ramalingam. The program is part of a multi-year program that started in 2012 and ends in 2014. Below is a summary of the work. Major common cause of subglotis is endotracheal intubation during the critical first days of life. In the premature infant and newborn patient, thi condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Further, the tissues of the subglottis are delicate in nature, easily ...

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    16. Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment

      Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment

      Methodist Hospital Research Institute receives a $301,316 NIH grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment. The principal investigator is Seok-Hyun (Andy) Yun. The program is part of a multi-year program that started in 2012 and ends in 2014. Below is a summary of the work. Core 2 will provide the five projects with a number of unique advanced optical systems; collaborate with the project investigators in the design, execution, and analysis of animal experiments; and develop new instrumentation and methodology as needs arise. The Core will be established in Boston within the Wellman Center ...

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    17. University of Alabama at Birmingham Receives NIH Grant for Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using MicroOCT

      University of Alabama at Birmingham Receives NIH Grant for Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using MicroOCT

      University of Alabama at Birmingham Received a $599,221 2013 NIH Grant for Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using MicroOCT. The principal investigator is Steven Rowe. The program is part of a multiyear program that started in 2012 and ends in 2016. Below is a summary of the work. Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an anion transporter of chloride and bicarbonate. Defective or deficient CFTR leads to severe mucoobstructive lung disease and severe morbidity and early mortality due to lung infections. Even though substantial ...

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    18. Mytek LLC Receives NIH Grant for Developing a Compact Swept Near-Infrared Light Source for Broadband Diffuse Optical Spectroscopy

      Mytek LLC Receives NIH Grant for Developing a Compact Swept Near-Infrared Light Source for Broadband Diffuse Optical Spectroscopy

      Mytek LLC Received a $272,604 2013 NIH Grant for Developing a Compact Swept Near-Infrared Light Source for broadband Diffuse Optical Spectroscopy. The principal investigator is Matthew Dummer. The program is part of a multi-year program that started in 2012 and ends in 2013. Below is a summary of the work. This project will develop a swept near-infrared light source that enables a portable hyperspectral tomographic functional optical imager. While such a device has many applications within endogenous NIR spectroscopy and imaging, or molecular imaging spectroscopy, we will focus on the application of the light source within an instrument designed ...

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    19. Stanford University Receives NIH Grant for Molecular Imaging of Protein Glycosylation in Living Subject

      Stanford University Receives NIH Grant for Molecular Imaging of Protein Glycosylation in Living Subject

      Stanford University Received a $392,572 2013 NIH Grant for Molecular Imaging of Protein Glycosylation in Living Subjects. The principal investigator is Adam De La Zerda. The program is part of a multiyear program that started in 2012 and ends in 2017. Below is a summary of the work. The broad objective of this project is to develop instrumentation and chemistry imaging technologies to advance the study of protein glycosylation in living subjects. Protein glycosylation is the most abundant and complex posttranslational modification (PTM). Changes in protein glycosylation have been correlated with cancer progression, neurological disorders and many other diseases ...

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    20. Duke University Receives NIH Grant for Comparison of AMD Treatment Trials-OCT Reading Center

      Duke University Receives NIH Grant for Comparison of AMD Treatment Trials-OCT Reading Center

      The Duke University Received a $64,511 2013 NIH Grant for Comparison of AMD Treatment Trials-OCT Reading Center. The principal investigator is Glenn Jaffe. The program is part of a multiyear program that started in 2006 and ends in 2013. Below is a summary of the work. The primary objective of the activities proposed in this application is to provide optical coherence tomography (OCT) Reading Center support to the Comparison of Age Related Macular Degeneration Treatment trial (CATT) during the conclusion of the CATT randomized clinical trial phase, and for the subsequent 3-year follow-up phase. The long term goals of ...

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      Mentions: Duke University
    21. University of Miami Receives NIH Grant for Advanced Imaging for Diabetic Retinopathy

      University of Miami Receives NIH Grant for Advanced Imaging for Diabetic Retinopathy

      The University of Miami Received a $497,284 2013 NIH Grant for Advanced Imaging for Diabetic Retinopathy. The principal investigator is Delia Cabrera Debuc. The program is part of a multiyear program that started in 2011 and ends in 2016. Below is a summary of the work. Diabetic retinopathy (DR) is a major cause of visual loss in diabetic individuals that presents a significant diagnostic challenge. Advances in preventing vision loss in these individuals are hindered by limited understanding of mechanisms underlying DR and the altered relationships between the retinal neural tissue and retinal vasculature. Therefore, an objective test for ...

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    22. MGH Receives NIH Award for Image-Guided and Model-Based Optical Dosimetry Tools

      MGH Receives NIH Award for Image-Guided and Model-Based Optical Dosimetry Tools

      Massachusetts General Hospital received a 2013 NIH Award for $113,925 for Image-Guided and Model-Based Optical Dosimetry Tools. The principal Investigator is Brian Pogue. Below is a summary of that work. This project advances the use of two novel technologies to image tissue in experimental cancer models and in patients, and will test hypothesis that these can be used to image tissue biophysical parameters, photosensitizer concentration and blood flow in tumors. The central theme in this project is that optical spectroscopy can be used in vivo to accurately measure bulk tissue values, but must be used in a way, which ...

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    23. Duke University Receives $994,553 NIH Award for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Receives $994,553 NIH Award for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University received a 2013 NIH Award for $994,553 for Intraoperative OCT Guidance of Intraocular Surgery. This is the first installment of a new four year Biomedical Research Partnership award funded by the National Eye Institute. The Partnership includes investigators from the Departments of Biomedical Engineering and Ophthalmology at Duke University and the Cole Eye Institute of the Cleveland Clinic Foundation. The project is lead by multiple principal investigators Joseph Izatt, Ph.D., and Cynthia Toth, M.D., both of Duke University. M.D. Below is a summary of that work. This Bioengineering Research Partnership proposal brings together a ...

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    24. Columbia University Receives NIH Award for Studying Models and Mechanisms of Optic Nerve Diseases

      Columbia University Receives NIH Award for Studying Models and Mechanisms of Optic Nerve Diseases

      Columbia University received a 2013 NIH Award for $354,975 for Studying Models and Mechanisms of Optic Nerve Diseases. The principal Investigator is Donald Hood. This part of a multi-year program that started in 1977 and ends in 2015. Below is a summary of that work. Glaucoma is the second leading cause of blindness in the world, but, with proper treatment, blindness can be avoided in 90% of individuals with glaucoma. Proper treatment begins with the detection of glaucoma. Our long-term goal is to improve the detection of early glaucomatous damage, as well as the detection of progression of such ...

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