1. Articles in category: Funding

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    1. Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition

      Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition

      Boston Medical Center Receives a 2019 NIH Grant for $197,189 for Eye To Brain: Eye Biomarkers and Cognition. The principal investigator is Manju Subramanian. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. The goal of our research is to identify ocular biomarkers that have diagnostic and potentially prognostic utility in Alzheimer's Disease (AD), and establish a relationship to cognition. We seek to determine this relationship in an already established cohort of patients (the Vitreous Biomarkers Study, or VBS) with eye disease where protein biomarkers have been identified in the ...

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    2. Physical Sciences Receives NIH Grant for Optical Prove for Real-Time Assessment of Periodontal Health Status

      Physical Sciences Receives NIH Grant for Optical Prove for Real-Time Assessment of Periodontal Health Status

      Physical Sciences Incorporated Received a 2019 NIH Grant for $641,715 for Optical Prove for Real-Time Assessment of Periodontal Health Status. The principal investigator is Nicusor Iftimia. The program began in 2013 and ends in 2020. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA is proposing to develop a technology that will address a major unmet medical need in periodontology: the lack of tools to quantitatively and objectively assess the health/disease status of the gingival soft tissues. The proposed technology will combine high resolution micro-Optical Coherence Tomography ...

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    3. University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives a 2019 NIH Grant for $381,250 for Choroidal Disease Mechanisms in AMD. The principal investigator is Elliott Sohn. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. We propose to investigate the pathophysiology of choroidal degeneration in age-related macular degeneration (AMD), the most common form of untreatable central vision loss in the western world. The choroid, the complex vascular system supplying the outer retina, photoreceptors, and retinal pigment epithelium (RPE), can now be visualized in living humans using enhanced depth imaging optical coherence tomography (OCT). Recent studies ...

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    4. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives NIH Grant  for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives a 2019 NIH Grant for $39,955 for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography. The principal investigator is Brian Soetikno. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The retina is one of the most metabolically active tissues in the human body, making it particularly susceptible to hypoxia. In diabetic retinopathy (DR), aberrant oxygen metabolism has been hypothesized to play a pivotal role its pathogenesis. An improved understanding of how imbalances in oxygen delivery and demand lead to the progression of DR ...

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    5. University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives a 2019 NIH Grant for $487,053 for Understanding Otoacoustic Emissions. The principal investigator is Christopher Shera. The program began in 1999 and ends in 2024. Below is a summary of the proposed work. Realizing the potential of otoacoustic emissions (OAEs) as noninvasive probes of cochlear function requires understanding the physical and physiological mechanisms that generate and shape these sounds. To address important unresolved issues of cochlear mechanics while improving our understanding of OAE generation, we propose three aims involving innovative theoretical modeling rigorously tested by experimental measurements. The first Aim studies the action of ...

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    6. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives a 2019 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dyanamics. The principal investigator is Sueng Shen. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not ...

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    7. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives a 2019 NIH Grant for $408,735 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion ...

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    8. Indiana University Receives NIH Grant for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells

      Indiana University Receives NIH Grant for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells

      Indiana University Receives a 2019 NIH Grant for $452,718 for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells. The principal investigator is Donald Miller. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Ganglion cells (GCs) and other inner retinal neurons are fundamental to retinal neural circuitry, processing photoreceptor signals relayed from intermediate neurons for transmission to the brain. Yet, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. GCs in particular are lost to neurodegenerative disorders such as glaucoma, Alzheimer’s disease ...

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    9. University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging

      University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging

      University of Houston Receives a 2019 NIH Grant for $676,224 for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging. The principal investigator is David Mayerich The program began in 2019 and ends in 2024. Below is a summary of the proposed work. The ability to correlate between large-scale developmental milestones and micro-scale cellular and protein- specific changes is a significant unmet need in the study of developmental biology. The overall objective of this work is to develop a multi-modality imaging platform that can provide time resolved three-dimensional images of tissue development, with high temporal and spatial ...

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    10. University of Alabama at Birmingham Receives NIH Grant for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression

      University of Alabama at Birmingham Receives NIH Grant for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $635,960 for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression. The principal investigator is Massimo Fazio. The program began in 2017 and ends in 2021. Below is a summary of the proposed work. This proposal is focused on morphological changes in the lamina cribrosa with glaucoma onset and progression, and how those changes impact visual function, with a focus on racial disparities. This project leverages on the longitudinal monitoring of a subset of glaucoma patients in the existing ADAGES cohort of which ...

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    11. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2019 NIH Grant for $63,746 for Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for ...

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    12. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...

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    13. Interdisciplinary UCLA team wins funding for laser eye research

      Interdisciplinary UCLA team wins funding for laser eye research

      A n interdisciplinary team of UCLA engineers and medical professionals has won an award from the UCLA Innovation Fund for their work in advancing efforts to image structures of the eye using lasers. The endeavor is a collaboration between Kouros Nouri-Mahdavi , an assistant professor of ophthalmology in the glaucoma division of the UCLA Jules Stein Eye Institute, Chee Wei Wong , professor of electrical and computer engineering in the UCLA Samueli School of Engineering, and Jinghui Yang and Yoon-Soo Jang, two research scientists in Wong’s lab . Organized by the UCLA Technology Development Group, the UCLA Innovation Fund ’s goal is ...

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    14. Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head

      Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head

      Emanuel Hospital and Health Center Receives a 2019 NIH Grant for $579,552 for IOP-Related Force and Failure in the Optical Nerve Head. The principal investigator is Claude Burgoyne. The program began in 2018 and ends in 2021. Below is a summary of the proposed work. In the previous project period we completed our 3D histomorphometric characterization of connective tissue deformation and remodeling in early through end-stage monkey experimental glaucoma (EG). Based on those findings, in this renewal proposal we will seek to identify important molecular and cellular components of optic nerve head (ONH) connective tissue and retrolaminar myelin remodeling ...

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    15. UC San Diego Receives NIH Grant for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Diseas

      UC San Diego Receives NIH Grant for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Diseas

      University of California at San Diego Receives a 2019 NIH Grant for $392,468 for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Disease. The principal investigator is Linda Zangwill. The program began in 2017 and ends in 2022. Below is a summary of the proposed work. This new study, Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced Disease, will overcome barriers to detection of progressive OAG in two cohorts of patients who are among the most challenging clinically to manage, OAG patients with advanced disease (advOAG) and OAG patients with high myopia (mypOAG). Determining whether ...

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    16. Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives a 2019 NIH Grant for $761,782 for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care. The principal investigator is Cynthia Toth. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that may impact vision in vulnerable preterm neonates for a lifetime. Clinical care of infants with ROP decreases the likelihood of blindness, but abnormal vision is common, especially in those with disease severe enough to require treatment. Because it has ...

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    17. Vanderbilt University Receives NIH Grant for In Vivo Molecular Imaging of Vascular Disease of the Retina

      Vanderbilt University Receives NIH Grant for In Vivo Molecular Imaging of Vascular Disease of the Retina

      Vanderbilt University Receives a 2019 NIH Grant for $431,513 for In Vivo Molecular Imaging of Vascular Disease of the Retina. The principal investigator is Imam Uddin. The program began in 2019 and ends in 2024. Below is a summary of the proposed work. Neovascularization (NV) is a common complication in age-related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP) and retinal vein occlusion (RVO). Retinal hypoxia plays an important role during NV development and progression. Thus, in vivo molecular imaging of retinal hypoxia at an early stage could be an important predictive tool assessing the risk of ...

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    18. University of Miami Receives NIH Grant for Intraoperative OCT-Based Wavefront Aberrometer

      University of Miami Receives NIH Grant for Intraoperative OCT-Based Wavefront Aberrometer

      University of Miami Receives a 2019 NIH Grant for $191,875 for Intraoperative OCT-Based Wavefront Aberrometer. The principal investigator is Marco Ruggeri. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. The long term goal of the project is to develop a combined intraoperative aberrometer and Optical Coherence Tomography (OCT) system optimized for cataract surgery guidance. Currently, surgeons rely on eye biometry performed before surgery to make their best guess as to the correct intraocular lens (IOL) power and how to position it inside the eye. The current approach does not deliver ...

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    19. Boston Medical Center Receives NIH Grant for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications

      Boston Medical Center Receives NIH Grant for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications

      Boston Medical Center Receives a 2019 NIH Grant for $669,582 for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications. The principal investigator is Hemat Roy. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. The overall goal of this project is to develop a rectal probe for minimally intrusive highly accurate risk stratification with the vision of utilizing it for a precision medicine approach to colon cancer screening and also potentially chemoprevention (companion biomarker). We will employ cutting edge biophotonics (ISOCT) and biological approaches combined with large scale human studies to elucidate ...

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    20. UC Davis Receives NIH Grant for Mechanisms of Visual Transduction

      UC Davis Receives NIH Grant for Mechanisms of Visual Transduction

      University of California at Davis Receives a 2019 NIH Grant for $438,120 for Mechanisms of Visual Transduction. The principal investigator is Edward Pugh. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Human vision operates over a billion-fold range of light intensities ranging from starlight to bright daylight, with night vision subserved by retinal rod photoreceptor cells, and day vision by cone photoreceptor cells. Rods and cones mediate the first steps in vision by capturing light in their G-protein coupled receptors Rhodopsin, and L/M and S-cone opsins, respectively, whose activation ...

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    21. Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives a 2019 NIH Grant for $428,832 for Auditory Mechanics and Cochlear Amplification. The principal investigator is Elizabeth Olson. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. Sound input to the inner ear (cochlea) causes a frequency-segregated wave-pattern of sensory tissue motion that conveys sound information to the auditory neurons, leading to hearing. A currently untreatable aspect of hearing impairment is the deterioration of the cochlea's ability to sharply segregate sound by frequency. The cochlea's healthy frequency tuning is largely provided by the cochlear amplifier, an ...

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    22. Johns Hopkins University Receives NIH Grant for Intra-Operative, Label-Free Detention of Brain Cancer infiltration with Quantitative Optical Imaging

      Johns Hopkins University Receives NIH Grant for Intra-Operative, Label-Free Detention of Brain Cancer infiltration with Quantitative Optical Imaging

      Johns Hopkins University Receives a 2019 NIH Grant for $589,760 for Intra-Operative, Label-Free Detention of Brain Cancer infiltration with Quantitative Optical Imaging. The principal investigator is Xingde Li The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Glioma is the most common adult primary brain cancer, with inevitable recurrence and finite survival times. Safe maximal resection for glioma patients remains the standard of care based on best evidence medicine (coupled with adjuvant therapies such as radiation and chemotherapy). Multiple studies have shown clear relief of symptoms, improvement of life quality, survival ...

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    23. Children's Hospital of Philadelphia Receives NIH Grant for Biomarkers of Vision Loss in Children with Optical Pathway Gliomas

      Children's Hospital of Philadelphia Receives NIH Grant for Biomarkers of Vision Loss in Children with Optical Pathway Gliomas

      Children's Hospital of Philadelphia Receives a 2019 NIH Grant for $686,771 for Biomarkers of Vision Loss in Children with Optical Pathway Gliomas. The principal investigator is Robert Avery. The program began in 2019 and ends in 2024. Below is a summary of the proposed work. Low-grade gliomas are the most common brain tumor in children and frequently involve the optic nerve, chiasm, and tract—so they are referred to as optic pathway gliomas (OPGs). OPGs cause vision loss, typically between 1 and 8 years of age, resulting in lifelong disability as well as reduced academic and vocational achievement ...

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    24. University of Alabama Receives NIH Grant for In Vivo Ultrastructure of Chorioretinal Disease

      University of Alabama Receives NIH Grant for In Vivo Ultrastructure of Chorioretinal Disease

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $367,500 for In Vivo Ultrastructure of Chorioretinal Disease. The principal investigator is Yuhua Zhang. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is a leading cause of vision loss in more than 10 million older Americans. For decades, AMD has been characterized by accumulation of extracellular lesions called drusen on the inner surface of Bruch's membrane (BrM), posterior to the retinal pigment epithelium (RPE), in a compartment called the sub-RPE space. Drusen are now ...

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