1. Articles in category: Funding

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    1. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2019 NIH Grant for $1,230,507 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease .The principal investigator is Danny Wang. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are inaccessible to existing imaging technologies. Characteristic parenchymal lesions on ...

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    2. Columbia University Receives NIH Grant for Measures of Human Receptor and post Receptor Activity

      Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity

      Columbia University Receives a 2019 NIH Grant for $636,552 for Measures of Human Receptor and post Receptor Activity. The principal investigator is Donald Hood. Below is a summary of the proposed work. Our long-term objective has been to develop noninvasive techniques for studying the human retina for both basic science and clinical purposes. By applying current theories of phototransduction to the full-field electroretinogram (ERG), we successfully developed widely used techniques for studying the global activity of the rod and cone receptors, as well as the rod bipolar cells. These indices of objective retinal function are appropriate outcome measures for ...

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    3. University of Alabama Receives NIH Grant for Clinical and Translational Core.

      University of Alabama Receives NIH Grant  for Clinical and Translational Core.

      University of Alabama Receives a 2019 NIH Grant for $225,529 for Clinical and Translational Core. The principal investigator is Steven Rowe. Below is a summary of the proposed work. Experimental techniques that require measurements in cystic fibrosis (CF) patients and tissues have demonstrated clear utility in CF science. Such capabilities have enabled advances including important contributions to our understanding of basic aspects of disease pathogenesis, characterization of novel therapeutics directed towards CF ion transport defects, and the evaluation of CFTR modulators in human subjects. The purpose of Core C is to provide resources, expertise, and support to a wide ...

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    4. University of Alabama Receives NIH Grant for Cell Model Evaluation Core.

      University of Alabama Receives NIH Grant for Cell Model Evaluation Core.

      University of Alabama Receives a 2019 NIH Grant for $241,719 for Cell Model Evaluation Core. The principal investigator is Bradford Woodworth. Below is a summary of the proposed work. A Well-differentiated primary human airway epithelial cells and the assays that can be used with them are an instrumental model for understanding epithelial biology and are highly predictive of in vivo results in clinical trials. Primary cells can be used with methodologies that translate readily to assays of airway function in vivo, including measures of CFTR activity or other ion transporters, airway surface liquid depth and mucus hydration, and mucus ...

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    5. Doheny Eye Institute Receives NIH Grant for Discovery and Validation of AMD Biomarkers for Progression Using Deep Learning

      Doheny Eye Institute Receives NIH Grant for Discovery and Validation of AMD Biomarkers for Progression Using Deep Learning

      Doheny Eye Institute Receives a 2019 NIH Grant for $235,500 for Discovery and Validation of AMD Biomarkers for Progression Using Deep Learning. The principal investigator is Zhihong Hu. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is the leading cause of blindness among elderly individuals. Currently there are no proven effective therapies for treatment of advanced non-neovascular AMD, termed geographic atrophy (GA). Earlier intervention may be preferable, but this would require identification of those individuals with the highest risk for progression to atrophy. Over the last two decades, various studies including ours have identified several ...

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      Mentions: UCSF Zhihong Hu
    6. Massachusetts General Hospital Receives NIH Grant for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant  for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $179,280 for Low Risk In Vivo Diagnosis of IPF with Optical Imaging. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, ultimately fatal form of idiopathic interstitial pneumonitis (IIP), with a 3 year survival rate of 0%. Diagnostic certainty of IPF is critical to patient management and therapeutic decision-making. Two new FDA-approved therapies, pirfenidone and nintedanib, have been shown to slow disease progression in IPF and brought new hope to IPF patients. Due to their high costs, side ...

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    7. Indiana University Receives NIH Grant for Objective Outcome Measure for clinical Assessment of Erosive Tooth Wear

      Indiana University Receives NIH Grant for Objective Outcome Measure for clinical Assessment of Erosive Tooth Wear

      Indiana University Receives a 2019 NIH Grant for $198,747 for Objective Outcome Measure for clinical Assessment of Erosive Tooth Wear. The principal investigator is Anderson Hara. Below is a summary of the proposed work. Erosive tooth wear (ETW) is a multifactorial and cumulative condition of growing prevalence that leads to substantial loss of dental structure, resulting in pain and harm to dental function and esthetics. Specifically in the USA, it affects approximately 46% of teenagers and 80% of adults. Despite these alarming numbers, USA dental professionals are largely unaware of this condition, and specific diagnostic set rules and management ...

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    8. Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2019 NIH Grant for $186,711 for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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    9. Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex

      Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex

      Massachusetts General Hospital Receives a 2019 NIH Grant for $463,473 for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex. The principal investigator is Anastasia Yendiki. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The objective of the proposed research is to map the organization of human white matter (WM) with cutting-edge ex vivo imaging technologies. This work will produce microscopic-level information on several long-range WM projections, as well as a more targeted mapping of circuits that serve the prefrontal cortex (PFC). These circuits are of particular interest in ...

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    10. Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives a 2019 NIH Grant for $300,000 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy ...

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    11. Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT

      Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT

      Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable Vertical Cavity Surface Emitting Lasers for Low-Cost Ophthalmic Swept Source Optical Coherence Tomography. The principal investigator is Christopher Burgner. The program began in 2012 and ends in 2020. Below is a summary of the proposed work. The ultimate goal of this effort is to bring advanced ophthalmic swept source optical coherence tomography (SS-OCT) imaging to low cost broadly accessible environments. SS-OCT is a powerful non-invasive diagnostic imaging modality, and an increasingly valuable tool in the early detection and monitoring of a number ...

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    12. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives a 2019 NIH Grant for $299,221 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...

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    13. MGH Receives NIH Grant for Quantitative Biomechanics Imaging

      MGH Receives NIH Grant for Quantitative Biomechanics Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $340,916 for Quantitative Biomechanics Imaging. The principal investigator is Seok-Hyun Andy Yun. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. TRD 1 The proposed research in TRD Project 1 is to develop novel optical coherence tomography (OCT)-based techniques and tools for measuring the mechanical properties and parameters as well as acoustic transduction in tissues. The focus on tissue biomechanics responds to the emerging opportunity to harness OCT's unique capabilities to obtain quantitative maps of tissue vibration, deformation, strain, and ...

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    14. MGH Receives NIH Grant for: Percutaneous and Interstitial Imaging

      MGH Receives NIH Grant for: Percutaneous and Interstitial Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $317,085 for TRD23: Percutaneous and Interstitial Imaging. The principal investigator is Martin Villiger. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. TRD 3 The overall goal of TRD 3 is to enable advanced OCT imaging, with high resolution and functional and dynamic contrast, inside the living body, through narrow diameter, rotational probes. Instruments and algorithms will be developed that overcome fundamental barriers, intrinsic to flexible, rotational fiber-optic probes, that have previously compromised image quality and prohibited the integration of functional and ...

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    15. MGH Receives NIH Grant for TRD: Functional Imaging

      MGH Receives  NIH Grant  for TRD: Functional Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $338,551 for TRD: Functional Imaging. The principal investigator is Benjamin Vakoc. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. TRD 2 TRD project 2 will develop novel optical coherence tomography (OCT) technologies to address unmet needs in the functional imaging of tissue. Specific Aim #1 addresses the need for high-speed and high- resolution angiographic imaging systems for preclinical research. A new high-speed optical architecture for high-resolution optical coherence microscopy (OCM) will be constructed that is 100 times faster than existing OCM ...

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    16. MGH Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      MGH Receives  NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2019 NIH Grant for $749,999 for the Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource ...

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    17. UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT for In-vivo identification of Bacterial Otitis Media

      UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT  for In-vivo identification of Bacterial Otitis Media

      University of Illinois at Urbana Champaign Receives a 2019 NIH Grant for $648,154 for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-vivo identification of Bacterial Otitis Media. The principal investigator is Stephen Boppart. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Otitis media (middle ear infection) is a highly prevalent disease, especially in young children. It has been documented that more than 75% of children will have at least one episode of otitis media (OM) by age 3, and many children will have recurrent or chronic OM ...

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    18. Veterans Affairs Medical Center in San Francisco Receives a 2019 NIH Grant for Collateral Flow and Stroke Outcome

      Veterans Affairs Medical Center in San Francisco Receives a 2019 NIH Grant for Collateral Flow and Stroke Outcome

      Veterans Affairs Medical Center in San Francisco Receives a 2019 NIH Grant for Collateral Flow and Stroke Outcome. The principal investigator is Jialing Liu. . Below is a summary of the proposed work. Collateral status is an independent predictor of stroke outcome, as well as response to thrombolytic therapies in patients with ischemic stroke. Genetic factors contribute to the extent and development of native collaterals, whereas patients with metabolic syndromes are associated with poor collateral status during acute ischemic stroke. Diabetes increases the risk of stroke and exacerbates ischemic brain damage, although the impact of diabetes on collateral dynamics remains to ...

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    19. Baylor College of Medicine Receives NIH Grant for Biomechanics of Early Cardiogenesis

      Baylor College of Medicine Receives NIH Grant for Biomechanics of Early Cardiogenesis

      Baylor College of Medicine Receives a 2019 NIH Grant for $554,542 for Biomechanics of Early Cardiogenesis. The principal investigator is Irina Larina. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Human congenital heart defects (CHD) are very common, occurring in nearly 1% of live births. Moreover, cardiovascular (CV) failures are the leading cause of birth defect- related deaths in infants. It is well established that biomechanical stimuli are important regulators of CV development. Thus, defining how mechanical factors are integrated with genetic pathways to coordinate mammalian heart tube function and ...

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    20. Case Western Reserve University Receives NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives a 2019 NIH Grant for $493,857 for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects. The principal investigator is Michael Jenkins. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Congenital heart defects (CHDs) are one of the most common and devastating birth defects, afflicting 32,000 babies born in the United States each year, and over 1 million Americans alive today. Altered hemodynamics during development has been shown to be a contributing factor to CHDs, regardless of whether ...

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    21. Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives a 2019 NIH Grant for $499,978 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system suitable for diagnostic retinal imaging at the point of care. The target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systems ...

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    22. Lumedica looks to fine-tune low-cost OCT system with SBIR grant

      Lumedica looks to fine-tune low-cost OCT system with SBIR grant

      Lumedica's low-cost OCT system Lumedica , the startup company spun out of co-founder Adam Wax’s Duke University research group, has won a $1 million small business innovation research (SBIR) grant to further develop its low-cost optical coherence tomography (OCT) platform. The Phase II funding, supported by the US National Institutes of Health (NIH) and National Eye Institute (NEI), is intended to help the company deliver a system for point-of-care diagnosis of debilitating retinal diseases. Meanwhile, Wax and colleagues have just published results from the first clinical study using Lumedica equipment for retinal iamging, with results suggesting strong potential for ...

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    23. University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy

      University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy

      University of Washington Receives a 2019 NIH Grant for $364,428 for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy. The principal investigator is Ruikang Wang. The program began in 2018 and ends in 2022. Below is a summary of the proposed work. The increasing incidence of diabetes in the US population and the inertial wave of aging in Americans will ensure that diabetic retinopathy (DR) remains one of the principal threats to the sight of adult patients and a significant management challenge for the clinical community. It is now clear that the peripheral retina is the ...

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    24. Aeon Imaging Receives NIH Grant for Confocal and Autofluorescence Imaging of Macular Degeneration Using a Low Cost Digital Imager

      Aeon Imaging Receives  NIH Grant for Confocal and Autofluorescence Imaging of Macular Degeneration Using a Low Cost Digital Imager

      Aeon Imaging Receives a 2019 NIH Grant for Confocal and Autofluorescence Imaging of Macular Degeneration Using a Low Cost Digital Imager. The principal investigator is Mathew Muller. Below is a summary of the proposed work. The overall goal of the proposed SBIR Phase II research is to build and evaluate a low cost, multi-mode retinal camera used to detect and manage causes of macular impairment. Age-related macular degeneration (AMD) remains the most common cause of permanent vision loss in the US and many industrialized countries. Treatments with portable lasers and injectable drugs can save sight, but early detection and careful ...

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    1-24 of 739 1 2 3 4 ... 29 30 31 »
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