1. Articles in category: Funding

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    1. Galahad project completes development of high-resolution OCT

      Galahad project completes development of high-resolution OCT

      EU-funded research aims to improve retinal imaging for early screening of glaucoma. Galahad in use Galahad , a Horizon 2020 research project developing an OCT platform for improved early screening of glaucoma, has successfully completed its work, according to project coordinators Gooch & Housego ( G&H ). Launched in 2016 , Galahad - from Glaucoma Advanced, LAbel-free High resolution Automated OCT Diagnostics - has now reached the end of its three-year €4-million program to develop ultra-high resolution polarization-sensitive optical coherence tomography (UHR-PS-OCT). Ten European partners made up the consortium. "Over the last 36 months the project has had a major impact on the development of UHR-PS-OCT ...

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    2. University of Illinois at Chicago Receives NIH Grant for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas

      University of Illinois at Chicago Receives NIH Grant for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas

      University of Illinois at Chicago Receives a 2020 NIH Grant for $ 352,927 for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas. The principal investigator is Xincheng Yao. Below is a summary of the proposed work. This project is to investigate spatiotemporal interactions between neural activities and hemodynamic changes in the retina, and to explore quantitative mapping of retinal neurovascular coupling defects caused by neurodegenerative diseases. Retinal neurodegenerative diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR) and glaucoma, can produce severe vision losses if medical interventions cannot be provided promptly. As one ...

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    3. Dyad Medical Receives NIH Grant for Software For OCT Analysis of Vascular Stents

      Dyad Medical Receives NIH Grant for Software For OCT Analysis of Vascular Stents

      Dyad Medical Receives a 2020 NIH Grant for $ 1,085,076 for Software For OCT Analysis of Vascular Stents. The principal investigator is Ronny Shalev. Below is a summary of the proposed work. Dyad Medical, Inc. will create intravascular Optical Coherence Tomography (IVOCT) software for clinical, live time determination of stent apposition and for offline analysis of stent implantation. Every year, 100s of thousands of patients in the US are treated with intravascular stents creating an opportunity for both solutions. Although advancements such as drug eluting metal stents hinder restenosis, there remains significant room for improvement. Stent design parameters include ...

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    4. Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health and Science University Receives a 2020 NIH Grant for $493,238 for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the eye, including the cornea, conjunctiva, sclera, anterior chamber, iris, and crystalline lens. Anterior segment OCT is already widely used in ophthalmology. But a number of high-impact applications were held back ...

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    5. Cornell University Receives NIH Grant for Three-Dimensional Mechano-Microscopy of Stem Cell Niche

      Cornell University Receives NIH Grant for Three-Dimensional Mechano-Microscopy of Stem Cell Niche

      Cornell University Receives a 2020 NIH Grant for $191,422 for Three-Dimensional Mechano-Microscopy of Stem Cel Niche. The principal investigator is Steven Adie. Below is a summary of the proposed work. Biophysical properties of cellular microenvironments can act to direct the self-renewal and differentiation fate outcomes of stem cells in multiple tissue types. As an example, the stem cells resident in skeletal muscles (MuSCs, also called satellite cells) are highly sensitive to elasticity of their surrounding “niche” microenvironment. In culture models, elastic substrates corresponding to the more stiff microenvironments observed in muscle aging and diseases such as muscular dystrophy can ...

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    6. University of Illinois at Chicago Receives NIH Grantfor Differential Artery-Vein Analysis in OCT Angiography for Objective Classification of Diabetic Retinopathy

      University of Illinois at Chicago Receives NIH Grantfor Differential Artery-Vein Analysis in OCT Angiography for Objective Classification of Diabetic Retinopathy

      University of Illinois at Chicago Receives a 2020 NIH Grant for $362,544 for Differential Artery-Vein Analysis in OCT Angiography for Objective Classification of Diabetic Retinopathy. The principal investigator is Xincheng Yao. Below is a summary of the proposed work. This project aims to establish differential artery-vein analysis in optical coherence tomography angiography (OCTA), and to validate comprehensive OCTA features for automated classification of diabetic retinopathy (DR). Early detection, prompt intervention, and reliable assessment of treatment outcomes are essential to prevent irreversible visual loss from DR. It is known that DR can target arteries and veins differently. Therefore, differential artery-vein ...

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    7. UCLA Receives NIH Grant for Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies

      UCLA Receives NIH Grant for Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies

      University of California at Los Angeles Receives a 2020 NIH Grant for $249,063 for Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies. The principal investigator is Irena Tsui. Below is a summary of the proposed work. This application requests funding for a project to improve maternal fetal healthcare using retinal pictures called optical coherence tomography angiography. Pregnancy is a complex process that can lead to complications such as preterm birth and preeclampsia. Preterm birth occurs in about 1 out of 10 pregnancies and is increasing due to increasing rates of in vitro fertilization, advanced maternal age, and ...

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    8. Georgia Institute of Technology Receives NIH Grant for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology

      Georgia Institute of Technology Receives NIH Grant for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology

      Georgia Institute of Technology Receives a 2020 NIH Grant for $233,796 for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology. The principal investigator is Francisco Robles. Below is a summary of the proposed work. The extent of resection of brain tumors is one of the most important factors associated with prolonged survival for patients with brain cancer. Unfortunately, achieving complete resection of the preoperatively-defined tumor region remains a significant clinical challenge. This is due, in part, to the lack of intraoperative tools available to help surgeons differentiate between healthy tissue that ...

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    9. UCLA Receives NIH Grant for Vitreoretinal Surgery via Robotic Microsurgical System with Imaging Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      UCLA Receives NIH Grant for Vitreoretinal Surgery via Robotic Microsurgical System with Imaging Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      University of California at Los Angeles Receives a 2020 NIH Grant for $429,489 for Vitreoretinal Surgery via Robotic Microsurgical System with Imaging Guidance, Force Feedback, Virtual Fixture, and Augmented Reality. The principal investigator is Jean-Pierre Hubschman. Below is a summary of the proposed work. The aims of the present proposal are to extend our work with the Intraocular Robotic Interventional and Surgical System (IRISS) and augment it for teleoperated vitreoretinal surgery. Although novel technologies such as intraoperative optical coherence tomography (i-OCT) have been developed, vitreoretinal surgeons still lack critical information during surgery (e.g., the distance between pre-retinal membrane ...

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    10. Duke University Receives NIH Grant for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children

      Duke University Receives NIH Grant for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children

      Duke University Receives a 2020 NIH Grant for $192,944 for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children. The principal investigator is Sina Farsiu . Below is a summary of the proposed work. Eye diseases in young children, if not detected and treated early, can lead to serious vision loss and even blindness. We have pioneered development of handheld spectral domain optical coherence tomography (HH- SDOCT) imaging systems to provide 3-D visualization of intra-retinal structures. Our previous studies based on HH-SDOCT of neonatal retina have already provided unique and previously unseen information about disease progression in ...

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    11. University of Miami Receives NIH Grant for Endothelium/Descemet's Membrane Complex Optical Tomography

      University of Miami Receives NIH Grant for Endothelium/Descemet's Membrane Complex Optical Tomography

      University of Miami Receives a 2020 NIH Grant for $218,323 for Endothelium/Descemet's Membrane Complex Optical Tomography. The principal investigator is Mohamed Abou Shousha. Below is a summary of the proposed work. More than 50% of corneal transplants, the most common form of solid organ transplantation, are performed to restore vision lost secondary to corneal endothelial failure. More than 25% of those transplants will eventually fail and endothelial cell rejection leading to failure is the single most important cause. The key to protec the endothelium is the early and accurate diagnosis of cell injury to promptly initiate treatment ...

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    12. UC Davis Receives NIH Grant for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT

      UC Davis Receives NIH Grant for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT

      University of California at Davis Receives a 2020 NIH Grant for $245,576 for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT. The principal investigator is George Solomon. Below is a summary of the proposed work. The research proposed for this award will examine functional and structural properties of single cells in the human retina. The three Aims will link the candidate's scientific background and career plans to study the human retina using a combination of adaptive optics (AO) and optical coherence tomography (OCT) which provide high lateral and high axial resolution, respectively (~2.5 μm in all ...

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    13. USC Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      USC Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives a 2020 NIH Grant for $672,471 for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin growth in the middle ear which facilitates erosion of ...

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    14. Massachusetts General Hospital Receives NIH Grant for Unique Value of Real-Time Shear Stress To Enhance Coronary Disease Management

      Massachusetts General Hospital Receives NIH Grant for Unique Value of Real-Time Shear Stress To Enhance Coronary Disease Management

      Massachusetts General Hospital Receives a 2020 NIH Grant for $771,279 for Unique Value of Real-Time Shear Stress To Enhance Coronary Disease Management. The principal investigator is Guillermo Tearney. Below is a summary of the proposed work. Management of CAD is hindered by our inability to investigate fundamental pathobiologic processes that lead to individual coronary plaque progression, destabilization, and adverse clinical events. A critical mechanism responsible for plaque behavior is local endothelial shear stress (ESS), the frictional force of blood flowing across the endothelium, which is governed by the artery’s detailed local geometry. Focal regions of low ESS drive ...

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    15. Massachusetts General Hospital Receives NIH Grant for A Tethered Capsule Endoscopic-Endomicroscopic (TEEM) Approach for Improving Upper GI Tract Diagnosis

      Massachusetts General Hospital Receives NIH Grant for A Tethered Capsule Endoscopic-Endomicroscopic (TEEM) Approach for Improving Upper GI Tract Diagnosis

      Massachusetts General Hospital Receives a 2020 NIH Grant for $627,739 for A Tethered Capsule Endoscopic-Endomicroscopic (TEEM) Approach for Improving Upper GI Tract Diagnosis. The principal investigator is Guillermo Tearney. Below is a summary of the proposed work. The diagnosis of most upper GI tract conditions is currently accomplished by upper endoscopy with biopsy (EGD). EGD is costly primarily because it requires conscious sedation, necessitating that procedures be conducted by physicians in a specialized endoscopy suite, and that patients take time away from work and family. Another limitation is sampling error - endoscopic biopsies are frequently random, resulting in many instances ...

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    16. University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary motion in PCD

      University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary motion in PCD

      University of Alabama at Birmingham Receives a 2020 NIH Grant for $159,882 for Functional Categorization of Ciliary motion in PCD. The principal investigator is George Solomon. Below is a summary of the proposed work. Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous disorder of motile cilia that results in progressive lung disease due to abrogated mucociliary clearance. While new understandings of the genetics have been helpful for clinical diagnostics, functional testing of cilia are needed to understand and predict phenotypic variation and response to therapy. Recent work in our laboratory has identified a link between ciliary genetics and novel ...

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    17. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      Massachusetts Eye and Ear Infirmary Receives a 2020 NIH Grant for $491,220 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

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    18. University of Houston Receives NIH Grant for Relating Structure to Function in Optic Neuropathies

      University of Houston Receives NIH Grant for Relating Structure to Function in Optic Neuropathies

      University of Houston Receives a 2020 NIH Grant for $344,250 for Relating Structure to Function in Optic Neuropathies. The principal investigator is Nimesh Patel. Below is a summary of the proposed work. Glaucoma is a group of diseases that results in a pathological loss of retinal ganglion cells (RGC) and irreversible vision loss. Although glaucoma is an optic neuropathy with characteristic optic nerve head (ONH) changes, risk of developing disease is not based on ONH structure, but factors including intraocular pressure (IOP), central corneal thickness, age, race and family history. In early disease, there is significant thinning of the ...

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    19. Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives a 2020 NIH Grant for $164,676 for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology. The principal investigator is Eric Osborn. Below is a summary of the proposed work. Dr. Eric Osborn is an early career faculty member at Beth Israel Deaconess Medical Center (BIDMC) and Massachusetts General Hospital (MGH), and an Instructor in Medicine at Harvard Medical School, Boston, Massachusetts. He is a graduate of the MD-PhD program at Harvard Medical School and Massachusetts Institute of Technology, and has completed clinical training in medicine and subspecialty training in cardiology at BIDMC. His goal ...

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    20. University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a 2020 NIH Grant for $710,479 for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    21. Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization

      Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization

      Baylor College of Medicine Receives a 2020 NIH Grant for $541,789 for In Vivo Analysis of Mammalian Fertilization. The principal investigator is Irina Larina. Below is a summary of the proposed work. Estrous cycle, ovulation, fertilization, and pre-implantation pregnancy are fundamental reproductive processes of clinical importance. While research has shed light on the cellular and molecular mechanisms mediating these events, much of these data are derived from static histological analysis, low-resolution visualizations, and studies of invertebrate models (e.g. sea urchin). Therefore, any conclusions regarding mammalian fertilization, which takes place deep inside the body, are extrapolated and do not ...

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    22. University of Houston Receives NIH Grant for Artificial Intelligence for Optical Coherence Tomography To Study Effects of Poly-Drug Exposure on Fetal Brain Development

      University of Houston Receives NIH Grant for Artificial Intelligence for Optical Coherence Tomography To Study Effects of Poly-Drug Exposure on Fetal Brain Development

      University of Houston Receives a 2020 NIH Grant for $311,241 for Artificial Intelligence for Optical Coherence Tomography To Study Effects of Poly-Drug Exposure on Fetal Brain Development. The principal investigator is Kirill Larin. Below is a summary of the proposed work. The overall objective of this study is to develop an optical coherence tomography (OCT) based high- resolution mouse embryonic brain imaging and analysis approach, and to use this method in correlation with molecular analysis to understand the interplay between ethanol (EtOH) and nicotine (NIC) effects on embryonic brain development. Maternal exposures to these substances are linked to fetal ...

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    23. Doheny Eye Institute Receives NIH Grant for Artificial Intelligence for Assessment of Stargardt Macular Atrophy

      Doheny Eye Institute Receives NIH Grant for Artificial Intelligence for Assessment of Stargardt Macular Atrophy

      Doheny Eye Institute Receives a 2020 NIH Grant for $235,500 for Artificial Intelligence for Assessment of Stargardt Macular Atrophy. The principal investigator is Zhihong Hu. Below is a summary of the proposed work. Stargardt disease is the most frequent form of inherited juvenile macular degeneration. Fundus autofluorescence (FAF) is a widely available imaging technique which may aid in the diagnosis of Stargardt disease and is commonly used to monitor its progression. FAF imaging provides an in vivo assay of the retinal layers, but is only an indirect measure. Spectral-domain optical coherence tomography (SD-OCT), in contrast, provides three-dimensional visualization of ...

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    24. Reaching the last mile in eye care

      Reaching the last mile in eye care

      Primary care provides a place to which people can bring a wide range of health problems – it is not acceptable that in low-income countries primary care would only deal with a few priority diseases. World Health Report 2008 . On the eve of 2019 World Sight Day (WSD), the World Health Organization (WHO) released the World Report on Vision (WRV). [1] This report is based on three earlier WHO resolutions – primary eye care, universal health coverage, and sustainable development goals (SDG). [2] , [3] , [4] Primary care, often the first contact for patients, provides appropriate, accessible, and affordable care that meets patients ...

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  3. Organizations in the News

    1. (10 articles) National Institutes of Health
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