1. Articles in category: Funding

    1-24 of 550 1 2 3 4 ... 21 22 23 »
    1. Opticent Incorporated Receives NIH Grant for Clinical Optical Coherence Tomography for Retina Metabolic Imaging

      Opticent Incorporated Receives NIH Grant for Clinical Optical Coherence Tomography for Retina Metabolic Imaging

      Opticent Incorporated Receives a 2016 NIH Grant for $224,139 for Clinical Optical Coherence Tomography for Retina Metabolic Imaging. The principal investigator is Andrew Radosevich. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. The primary endpoint of this SBIR phase I proposal is to develop a method capable of monitoring retinal oxygen metabolism in patients undergoing treatment for vision-threatening diabetic retinopathy (DR) in the clinical Ophthalmology setting. I is estimated that by the year 2030 over 150 million individuals will suffer from DR worldwide. In its earliest form, DR is characterized ...

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    2. University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas

      University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas

      University of Washington Receives a 2016 NIH Grant for $235,226 for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...

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    3. University of North Carolina Receives NIH Grant for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus

      University of North Carolina Receives NIH Grant for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus

      University of North Carolina at Chapel Hill Receives a 2016 NIH Grant for $234,624 for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus. The principal investigator is Amy Oldenburg. The program began in 2016 and ends in 2018. Below is a summary of the proposed work. Mucus coats the lung epithelium and traps thousands of pathogens that we inhale every day. Human bronchial epithelial (hBE) cells lining the lung have cilia that propel mucus via shear forces, a mechanism known as muco-ciliary transport (MCT). MCT acts to clear mucus, providing a primary defense against trapped pathogens. In respiratory diseases ...

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    4. Jackson Laboratory Receives NIH Grant for Eye Mutan Resource

      Jackson Laboratory Receives NIH Grant for Eye Mutan Resource

      Jackson Laboratory Receives a 2016 NIH Grant for $437,500 for Eye Mutan Resource. The principal investigator is Bo Chang. The program began in 2010 and ends in 2019. Below is a summary of the proposed work. The main objective of the Eye Mutant Resource (EMR) is to identify, characterize, and preserve mice with genetically caused ocular disorders. Our purpose is to distribute these well-characterized models quickly and efficiently to support and promote vision research with the ultimate goal of advancing the elucidation, treatment, and cure of heritable eye diseases. Award of this grant is critical to the continuation of ...

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    5. Children's Hospital of Philadelphia Receives NIH Grant for Visual Outcome Measures in Children With Optical Pathway Gliomas

      Children's Hospital of Philadelphia Receives NIH Grant for Visual Outcome Measures in Children With Optical Pathway Gliomas

      Children's Hospital of Philadelphia Receives 2016 NIH Grant for $228,593 for Visual Outcome Measures in Children With Optical Pathway Gliomas. The principal investigator is Robert Avery. The program began in 2015 and ends in 2017. Below us a summary of the proposed work. This Mentored Patient-Oriented Research Career Development Award will prepare a pediatric neuroophthalmologist for an academic career as an independent multidisciplinary clinical researcher with a focus on vision outcomes in children with brain tumors of the visual pathway called optic pathway gliomas (OPGs). The candidate's application provides training needed to establish a clinical research career ...

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    6. Heads up displays for optical coherence tomography integrated surgical microscopes

      Heads up displays for optical coherence tomography integrated surgical microscopes

      Surgical microscope systems are provided including an optical coherence tomography (OCT) system; an objective lens; oculars for direct viewing of a subject distal to the objective lens; a heads up display module configured to direct an optical image through the oculars to be visible to a user of at least one ocular; and a coupling element connected to the surgical microscope coupling the OCT system, the heads up display module and the objective lens. The coupling element has first and second faces, the first face positioned toward the oculars of the surgical microscope and the second face positioned toward the ...

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    7. Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance

      Physical Sciences Incorporated Receives a 2016 NIH Grant for $475,423 for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2011 and ends in 2017. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Caliber Imaging & Diagnostics Inc. (Caliber ID), proposes to develop a hand-held reflectance confocal microscopy - optical coherence tomography (RCM-OCT) imaging probe and clinically evaluate its potential use for guiding laser ablation therapy of BCC basal cell carcinoma (BCC). While RCM provides en ...

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    8. Brigham and Women's Hospital Receives a NIH Grant for Aortic Valve Microcalicifacation

      Brigham and Women's Hospital Receives a NIH Grant for Aortic Valve Microcalicifacation

      Brigham and Women's Hospital Receives a 2016 NIH Grant for $415,740 for Aortic Valve Microcalicifacation. The principal investigator is Elena Aikawa. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. This research project will test the hypothesis that, in the diabetic milieu, S100A9 induces the calcification potential of valvular interstitial cell (VIC)-derived matrix vesicles, precursors of microcalcification, offering the novel mechanism of calcific aortic valve disease (CAVD). Our pilot studies showed that S100A9 - a recently identified biomarker of acute cardiovascular events - is expressed by VIC and a component of ...

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    9. University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives a 2016 NIH Grant for $662,015 for Interferometric Optophysiology of the Human Retina. The principal investigator is Austin Roorda. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Our goal is to develop a new technology for non-invasive optical monitoring of activity of individual retinal neurons and their light-driven inputs at cellular resolution, in the living human retina. If successful, this technology will provide an entirely new and objective approach to understand and monitor treatment of retinal disease, thereby transforming scientific studies of the eye ...

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    10. OCT Medical Imaging Inc. Receives a NIH Grant for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System

      OCT Medical Imaging Inc. Receives a NIH Grant for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System

      OCT Medical Imaging Inc. Receives a 2016 NIH Grant for $1,252,899 for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System. The principal investigator is Tirunelveli Ramalingam. The program began in 2015 and ends in 2018. Below is a summary of the proposed work. Understanding that not a single imaging technique can alone address needs of all vascular diagnosis, OCT medical imaging Inc. (OCTMI) propose to develop a clinical multimodal intravascular imaging system encompassing ultra-high resolution optical coherence tomography (OCT) and IVUS. This Combined multimodal vascular imaging system will permit cross-sectional visualization of vascular artery with ...

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    11. Johns Hopkins University Receives a NIH Grant for Tissue Pharmacology Imaging and Modeling

      Johns Hopkins University Receives a NIH Grant for Tissue Pharmacology Imaging and Modeling

      Johns Hopkins University Receives a 2016 NIH Grant for $542,099 for Tissue Pharmacology Imaging and Modeling. The principal investigator is Namandjen Bumpus. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. A successful microbicide product has pharmacokinetics (PK) that effect prophylactic pharmacodynamics (PD). Product design should manipulate candidate compositions, volumes, and drug packaging in a rational manner to yield target PK/PD; but we have limited understanding of this relationship. Further, our methods for experimentally evaluating PK in animals and humans are limited: they do not delineate drug concentration distributions throughout ...

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    12. Drs. Campbell, Hariri, and Lehman Receive 2016 LUNGevity Career Development Awards

      Drs. Campbell, Hariri, and Lehman Receive 2016 LUNGevity Career Development Awards

      Lida Hariri , MD, Massachusetts General Hospital, who will use a novel high-resolution imaging technique called Optical Coherence Tomography to perform virtual optical biopsies to determine its value in complementing tissue biopsies in the determination of early-stage lung cancer

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    13. Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for $573,805 for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy. The principal investigator is Guillermo Tearney. The program began in $2014 and ends in 2019. Below is a summary of the proposed work. Celiac disease (CD) is an autoimmune response to gluten proteins that affects 3M people in the US and 50M worldwide. These proteins incite an inflammatory reaction that eventually destroys the absorptive villi in the duodenum, resulting in gastrointestinal symptoms, malabsorption, malnutrition, and an increased incidence of other autoimmune diseases, diabetes, and cancer. A definitive diagnosis of CD is ...

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    14. UCLA Receives a NIH Grant for Detection of Glaucoma Progression With Macular OCT Imaging

      UCLA Receives a NIH Grant for Detection of Glaucoma Progression With Macular OCT Imaging

      The University of California at Los Angeles Receives a 2016 NIH Grant for $229,139 for Detection of Glaucoma Progression With Macular OCT Imaging. The principal investigator is Kourous Nouri-Mahdavi. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. This application is a formal request for a career development award (K23) for an academic glaucoma specialist with a serious interest in the role of imaging in glaucoma using optical coherence tomography (OCT). This will allow the candidate to establish a clinical research program with the main goal of improving detection of glaucoma ...

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    15. Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives a 2016 NIH Grant for $483,717 for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects. The principal investigator is Michael Jenkins. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Congenital heart defects (CHDs) are one of the most common and devastating birth defects, afflicting 32,000 babies born in the United States each year, and over 1 million Americans alive today. Altered hemodynamics during development has been shown to be a contributing factor to CHDs, regardless of whether ...

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    16. Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $590,459 for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The human brain is made up of an array of functionally and structurally defined regions. Localizing these regions is critical for early diagnosis of an array of diseases such as Alzheimer's disease (AD), as well as for neuroscientific research aimed at understanding the brain's functional and structural properties and clinical intervention in drug-resistant depression ...

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    17. Baylor College of Medicine Receives NIH Grant for Small Animal Visual System Module

      Baylor College of Medicine Receives NIH Grant for Small Animal Visual System Module

      Baylor College of Medicine Receives a 2016 NIH Grant for $139,554 for Small Animal Visual System Module. The principal investigator is Ching-Kang Chen. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. Recent advance in genome editing technology will lead to an explosion of small animal models of human diseases. These animal models, when characterized efficiently and correctly, will benefit investigations that elucidate disease mechanisms and lead to exciting discovery of therapeutic interventions. The small animal visual system analysis module (SAVSAM) of the Baylor College of Medicine (BCM) Vision Core Facilities ...

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    18. Massachusetts General Hospital Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $1,460,266 for the Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the propose work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the ...

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    19. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography ...

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    20. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of ...

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    21. Horizon 2020 project aims to transform optical coherence tomography

      Horizon 2020 project aims to transform optical coherence tomography

      Advances in silicon photonics development for datacom applications are set to be applied in biophotonics, with a new €4.9 million European project aiming to create a tiny and low-cost system for optical coherence tomography (OCT). While OCT has become widely used for ophthalmic diagnosis and is gaining traction in cardiovascular imaging, the technique still relies on relatively expensive and bulky combinations of laser, optical and electronic equipment. Now a team led by Wolfgang Drexler from the Medical University of Vienna is aiming to shrink the core technology to no more than the size of a coin, primarily to diagnose ...

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    22. Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives a 2016 NIH Grant for $742,986 for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function. The principal investigator is David Sosnovik. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. Pressure overload of the left and right ventricles initially leads to adaptive hypertrophy. This, however, is frequently followed by maladaptive hypertrophy, heart failure and death. We hypothesize here that changes in 3D myocardial fiber architecture play a significant role in the deleterious transition from adaptive to maladaptive hypertrophy and heart failure. We further hypothesize that ...

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    23. State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received a 2016 NIH Grant for $195,071 for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents. The principal investigator is Congwu Du. The program began in 2016 and ends in 2018. Below is a summary of the propose work. The medial prefrontal cortex (mPFC) plays a critical role in cocaine addiction. The mechanism underlying mPFC dysfunction in cocaine abusers are not well understood and could reflect disruption of cerebral blood flow (cocaine’s vascular effects) and/or disruption of dopaminergic modulation of the prefrontal cortex (cocaine’s ...

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    1-24 of 550 1 2 3 4 ... 21 22 23 »
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