1. Articles in category: Funding

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    1. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2017 NIH Grant for $37,696 Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for activation ...

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    2. Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives a 2017 NIH Grant for $139,730 for Imaging Structure and Function. The principal investigator is Thomas Clandinin. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Imaging technologies such as confocal microscopy, multiphoton microscopy and super- resolution imaging as well as optical coherence tomography have transformed the ability of scientists to observe structural and functional changes in the visual system, in vivo and ex vivo, in both health and disease. The overarching goal of the imaging core is to transform the ability of vision scientists to use these ...

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    3. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives a 2017 NIH Grant $317,544 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion from ...

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    4. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography (OCT ...

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    5. University of Miami Receives NIH Grant f for Dynamics of the Aging Ciliary Muscle

      University of Miami Receives NIH Grant f for Dynamics of the Aging Ciliary Muscle

      The long-term goal of this project is to enable the development of more effective treatments for presbyopia, the loss of near vision with age, by providing new insight into the mechanism behind presbyopia. The prevailing theory suggests that presbyopia is due mainly to age-related changes in the stiffness of the lens, but alternative theories have been proposed suggesting that age-related changes in the ciliary muscle may play a significant role. Age-related changes in the function of the ciliary muscle have been difficult to characterize in vivo due to the lack of suitable clinical imaging technology. The project will address two ...

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    6. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant  for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2017 NIH Grant for $1,191,714 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease. The principal investigator is Danny Wang. The program began in 2016 and ends in 2018. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are ...

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    7. Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives a 2017 NIH Grant for $50,000 Quantitative Imaging of Collagen Morphology in Human Scars. The principal investigator is Martin Villiger. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The overall goal of the proposed research is to develop and validate high-resolution birefringence imaging. The intrinsic birefringence of collagen offers an attractive contrast mechanism to investigate the collagen morphology in human skin and scars. Non-invasive characterization of the collagen organization in scar tissue would facilitate clinical trials that investigate novel therapeutic approaches to reduce scarring by providing ...

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    8. Physical Sciences, Incorporated Receives NIH Grant for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Physical Sciences, Incorporated Receives NIH Grant  for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Physical Sciences, Incorporated Receives a 2017 NIH Grant for $525,207 for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins. The principal investigator is Nicusor Iftima. The program began in 2014 and end sin 2019. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) and Caliber ID, Rochester, NY proposes to develop a novel technology for real-time assessment of surgical margins on breast cancer lumpectomy specimens and provide immediate feedback to the surgeon. A multimodal microscope will be used in conjunction with a high sensitivity cancer targeting agent ...

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    9. Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex

      Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex

      Massachusetts General Hospital Receives a 2017 NIH Grant for $474,273 for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex. The principal investigator is Anastasia Yendiki. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The objective of the proposed research is to map the organization of human white matter (WM) with cutting-edge ex vivo imaging technologies. This work will produce microscopic-level information on several long-range WM projections, as well as a more targeted mapping of circuits that serve the prefrontal cortex (PFC). These circuits are of particular interest in ...

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    10. LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients

      LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients

      LX Medical Corporation Receives a 2017 NIH Grant for $223,403 for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients. The principal investigator is Andrei Vertikov. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Lung transplantation is increasingly used to treat patients with end-stage lung diseases. Complications frequently occur with chronic allograft rejection causing most of late morbidity and mortality in lung transplant recipients. Pathological manifestations of chronic rejection mostly affect small airways or bronchioles in the lung, often progressing undetected until the patient presents with an ...

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    11. New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives a 2017 NIH Grant for $654,143 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2016 and ends in 2019. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of upmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project ...

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    12. University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core

      University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core

      University of Alabama at Birmingham Receives a 2017 NIH Grant for $43,191 for Occular Phenotyping Core. The principal investigator is Timothy Kraft. A summary of the proposed work is given below. Non-invasive assessment of eye structure and function is essential to both basic and translational research in vision science. Widely used technologies include slit lamp for biomicroscopy of anterior and posterior segment, electroretinography (ERG, for massed retinal signal separable into components), optical coherence tomography (OCT) for display of layered tissues in posterior and anterior segments, imaging of the fundus via multiple modes of visualization (color, autofluorescence, dye-based angiography, infrared ...

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    13. Massachusetts General Hospital Receives NIH Grant for Blood Flow-Based Guidance and Diagnostics Using OCT

      Massachusetts General Hospital Receives NIH Grant for Blood Flow-Based Guidance and Diagnostics Using OCT

      Massachusetts General Hospital Receives a 2017 NIH Grant for $173,504 for Blood Flow-Based Guidance and Diagnostics Using OCT. The principal investigator is Nestor Uribe-Patarroyo. The program began in 2017 and ends in 2021. Below is a summary of the proposed work. Diseases diagnosed with assessment of blood flow account for 29% of deaths in the US and are leading causes of premature morbidity, including visual disorders which carry an economic burden of $35 bil- lion per year. The heart disease with the most impact on public health is coronary artery disease (CAD); more than one million percutaneous coronary interventions ...

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    14. Indiana University Receives NIH Grant for Imaging Structure and Function of the Photoreceptor-RPE-Choriocapillaris Complex

      Indiana University Receives NIH Grant for Imaging Structure and Function of the Photoreceptor-RPE-Choriocapillaris Complex

      Indiana University Receives a 2017 NIH Grant for $461,610 for Imaging Structure and Function of the Photoreceptor-RPE-Choriocapillaris Complex. The principal investigator is Donald Miller. The program began in 2007 and ends in 2021. Below is a summary of the proposed work. Human vision starts when photoreceptors collect and respond to light. Photoreceptors do not function in isolation though, but share close interdependence with neighboring photoreceptors, retinal pigment epithelium (RPE) cells, and choriocapillaris (CC). These close interactions underlie normal function of photoreceptors, but also the entire photoreceptor-RPE-CC complex, the primary site of most retinal dystrophies including age-related macular degeneration (AMD ...

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    15. Massachusetts General Hospital Receives NIH Grant for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives a 2017 NIH Grant for $179,120 for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging. The principal investigator is Lida Hariri. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, ultimately fatal form of idiopathic interstitial pneumonitis (IIP), with a 3 year survival rate of 0%. Diagnostic certainty of IPF is critical to patient management and therapeutic decision-making. Two new FDA-approved therapies, pirfenidone and nintedanib, have been shown to slow disease progression in IPF and brought new ...

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    16. Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives a NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives a 2017 NIH Grant for $203,124 for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery. The principal investigator is Justis Ehlers. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Optical coherence tomography (OCT) has revolutionized the management of ophthalmic diseases with the precise anatomic information it provides with non-invasive imaging. The high-resolution cross-sectional tissue details make OCT a natural complement to ophthalmic surgery. Intraoperative OCT (iOCT) has the potential to provide real-time feedback to surgeons thus improving surgical care and outcomes. This research activity will focus on translating ...

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    17. Duke University Receives NIH Grant for Arbitrary Viewpoint Robotic Surgery

      Duke University Receives NIH Grant for Arbitrary Viewpoint Robotic Surgery

      Duke University Receives a 2017 NIH Grant for $4,165 for Arbitrary Viewpoint Robotic Surgery. The principal investigator is Mark Draelos. The program began in 2016 and ends in 2019. Below is a summary of the proposed work. Modern ophthalmic surgery depends on the stereo microscope for surgical field visualization to the extent that procedures best performed from alternate viewpoints are difficult if not impossible due to an inadequate view and non-intuitive surgical maneuvers. We seek to overcome limitations which physically couple the surgeon to both the stereo microscope and hand-held surgical instruments. This current paradigm causes ophthalmic mi- crosurgeons ...

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    18. Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain

      Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain

      Cornell University Receives a 2017 NIH Grant for $244,625 for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain. The principal investigator is Steven Adie. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. Optical imaging holds tremendous promise in our endeavor to understand brain functions. The major challenges for optical brain imaging are depth and speed. Due to strong tissue scattering, the penetration depth and imaging speed of optical microscopy in the mouse brain is very limited. These constraints in depth and speed make large scale ...

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    19. 'PhotonControl' uses Optical Coherence Tomography, Raman spectroscopy to test quality of bioprinted tissue | 3D Printer News & 3D Printing News

      'PhotonControl' uses Optical Coherence Tomography, Raman spectroscopy to test quality of bioprinted tissue | 3D Printer News & 3D Printing News

      Scientists from Würzburg and Lübeck in Germany are attempting to improve the quality control of 3D bioprinted tissue implants. Their “PhotonControl” system uses both Optical Coherence Tomography (OCT) and Raman spectroscopy (Raman) to test fabricated tissue. With its ability to repair damaged areas of the human body in a safe and cost-effective manner, 3D bioprinted tissue is on the rise. But since printed tissue is a relatively new concept, it’s important that scientists use thorough quality control measures in order to maintain patient safety. Unfortunately, that is often easier said than done: quality control can be difficult ...

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    20. Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives  NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives a 2017 NIH Grant for $603,912 for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The human brain is made up of an array of functionally and structurally defined regions. Localizing these regions is critical for early diagnosis of an array of diseases such as Alzheimer's disease (AD), as well as for neuroscientific research aimed at understanding the brain's functional and structural properties and clinical intervention in drug-resistant depression ...

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    21. Google DeepMind is funding NHS research at Moorfields Eye Hospital

      Google DeepMind is funding NHS research at Moorfields Eye Hospital

      DeepMind, the London-based artificial intelligence (AI) lab owned by Google, is funding research being carried out by the National Health Service (NHS). The company has paid Moorfields Eye Hospital NHS Foundation Trust £110,000 since it signed a deal with the hospital last July, according to a Freedom of Information request made by Business Insider. DeepMind and Moorfields are working together to see if DeepMind's AI technology can be used to help spot early signs of eye conditions that human eye care experts might miss. Specifically, Moorfields is applying DeepMind's algorithms to 1 million anonymous OCT (Optical Coherence ...

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    22. MGH Receives NIH Grant for $1,512,015 for Center for Biomedical OCT Research and Translation.

      MGH Receives NIH Grant for $1,512,015 for Center for Biomedical OCT Research and Translation.

      Massachusetts General Hospital Receives a 2017 NIH Grant for $1,512,015 for Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource ...

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    23. UIUC Receives a NIH Grant for Partnership for Primary Care Imaging of the Ear

      UIUC Receives a NIH Grant for Partnership for Primary Care Imaging of the Ear

      University of Illinois at Urbana-Champaign Receives a 2017 NIH Grant for $454,301 for Partnership for Primary Care Imaging of the Ear. The principal investigator is Stepen Boppart. The program began in 2011 and ends in 2019. Below is a summary of the proposed work. Biofilms in the human middle-ear are known to be directly associated with chronic otitis media (OM), and the bacteria that reside within these protective biofilms are likely responsible for contributing to the persistence and re-seeding of the infection despite repeated doses of antibiotics. While prior sampling of human middle-ear biofilms was performed invasively during a ...

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    24. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives a 2017 NIH Grant for $334,425 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...

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