1. Articles in category: Funding

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    1. MedLumics raises $21.8M to test its optically guided heart ablation catheter

      MedLumics raises $21.8M to test its optically guided heart ablation catheter

      The Madrid-based company’s AblaView system is equipped with sensors that use optical coherence tomography—an imaging technique using light to scan and penetrate a few millimeters of tissue—to directly observe the creation of ablation lesions in the cardiac muscle wall in real time and assure the correct placement of the catheter’s electrodes. The proceeds will help carry MedLumics into first-in-human clinical testing, following the preclinical feasibility studies it completed last year, the company said. The fundraising was backed by Asabys Partners, Kurma Partners, VI Partners Swiss Innovation, CDTI Innvierte Economía, Andera Partners, Caixa Capital Risc and ...

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      Mentions: MedLumics
    2. Johns Hopkins University Receives NIH Grant for Artificial Intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Kerotoplasty (Auto-Dalk)

      Johns Hopkins University Receives NIH Grant for Artificial Intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Kerotoplasty (Auto-Dalk)

      Johns Hopkins University Receives a 2021 NIH Grant for $409,997 for Artificial Intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Kerotoplasty (Auto-Dalk). The principal investigator is Jin U. Kang. Below is a summary of the proposed work. Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-instruments, where the outcomes are often limited by the surgeon's skill levels and experiences. To overcome these human factors, we have assembled an interdisciplinary team including a clinician-scientist and eye surgeon, an optical device scientist and medical robotic engineers to translate existing and ...

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    3. Oregon Science and Health University Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Science and Health University Receives NIH Grant  for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Science and Health University Receives a 2021 NIH Grant for $440,684 for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the eye, including the cornea, conjunctiva, sclera, anterior chamber, iris, and crystalline lens. Anterior segment OCT is already widely used in ophthalmology. But a number of high-impact applications were held back ...

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    4. Spectrawave Raises $13.2M for Intracoronary Imaging Solution

      Spectrawave Raises $13.2M for Intracoronary Imaging Solution

      SpectraWave today announced a $13.2 million Series A-2 financing to support completion of product development and regulatory filing for its flagship intracoronary imaging product, designed to help physicians optimize coronary stenting interventions and limit future adverse events. The funding round is led by prior investor Deerfield Management, and includes follow-on investment from prior unnamed seed investors. Coronary artery disease (CAD), the buildup of plaque in the wall of the coronary arteries that supply blood to the heart, causes 9 million deaths worldwide each year. In CAD, patients can undergo stent placement to relieve symptoms, but one in five patients ...

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    5. Nanoscope® team conferred Phase II Retinal Organoid Challenge (ROC) award by National Institute of Health

      Nanoscope® team conferred Phase II Retinal Organoid Challenge (ROC) award by National Institute of Health

      To meet the advance challenge for generating a physiologically relevant three-dimensional (3D) retinal organoid, Nanoscope researchers® in collaboration with University of Colorado, and Miami University were recently awarded the top prize from... We are also advancing OCT guided targeted laser microirradiation technology for creating models of degenerative eye diseases such as Retinitis Pigmentosa (RP) and dry age-related macular degeneration (dry-AMD) as well as for targeted delivery of therapeutic genes," said Sulagna Bhattacharya , CEO of Nanoscope.

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    6. Massachusetts General Hospital Receives NIH Grant for Unique Value of Real-Time Shear Stress to Enhance Coronary Disease Management

      Massachusetts General Hospital Receives NIH Grant for Unique Value of Real-Time Shear Stress to Enhance Coronary Disease Management

      Massachusetts General Hospital Receives a 2021 NIH Grant for $729,926 for Unique Value of Real-Time Shear Stress to Enhance Coronary Disease Management. The principal investigator is Guillermo Tearney. Below is a summary of the proposed work. Management of CAD is hindered by our inability to investigate fundamental pathobiologic processes that lead to individual coronary plaque progression, destabilization, and adverse clinical events. A critical mechanism responsible for plaque behavior is local endothelial shear stress (ESS), the frictional force of blood flowing across the endothelium, which is governed by the artery’s detailed local geometry. Focal regions of low ESS drive ...

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    7. Washington University in St. LouisReceives NIH Grant for High-Throughput Integrated Live Imaging and Optogentic Pacing Platform to Assess Hypoxia Responsiveness in the Fly Heart

      Washington University in St. LouisReceives NIH Grant for High-Throughput Integrated Live Imaging and Optogentic Pacing Platform to Assess Hypoxia Responsiveness in the Fly Heart

      Washington University Receives a 2021 NIH Grant for $529,434 for High-Throughput Integrated Live Imaging and Optogentic Pacing Platform to Assess Hypoxia Responsiveness in the Fly Heart. The principal investigator is Chao Zhou. Below is a summary of the proposed work. Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subsequent sustained episode of ischemia. An emerging body of evidence demonstrated that neural regulated heart rate modulation confers cardiac preconditioning responses. Understanding the mechanism through model systems of preconditioning would help us identify the genes and proteins when ...

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    8. University of California at San Diego Receives NIH Grant for OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-Up

      University of California at San Diego Receives NIH Grant for OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-Up

      University of California at San Diego Receives a 2021 NIH Grant for $182,600 for OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-Up. The principal investigator is Linda Zangwill. Below is a summary of the proposed work. The “Ocular Hypertension Treatment Study (OHTS 3): 20-year follow-up (Phase 3)” was designed to determine the incidence and severity of primary open angle glaucoma (POAG) in the longstanding OHTS cohort. and determine the frequency and severity of functional limitations associated with POAG. Moreover, this well-characterized cohort has precise information on the dates/timing of the development of POAG assessed by 3 ...

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    9. Massachusetts General Hospital Receives NIH Grant for Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives NIH Grant for Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives a 2021 NIH Grant for $662,413 for Early Detection and Diagnosis of Lung Cancer with Endomicroscopy. The principal investigator is Melissa Suter. Below is a summary of the proposed work. Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread offering patients little hope for cure (average 5-year survival rate < 15%). The U.S. Preventive Services Task Force recommends individuals at high risk of developing lung cancer undergo yearly screening with low dose computed tomography (LDCT). Screening is highly ...

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    10. University of Southern California Receives NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives NIH Grant for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma

      University of Southern California Receives a 2021 NIH Grant for $606,342 for Mechanisms of Cochlear Synaptopathy After Noise or Blast Trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    11. Dohney Eye Institute Receives NIH Grant for Artificial Intelligence for Assessment of Stargardt Macular Atrophy

      Dohney Eye Institute Receives NIH Grant for Artificial Intelligence for Assessment of Stargardt Macular Atrophy

      Dohney Eye Institute Receives a 2021 NIH Grant for $176,625 for Artificial Intelligence for Assessment of Stargardt Macular Atrophy. The principal investigator is Zhihong Hu. Below is a summary of the proposed work. Stargardt disease is the most frequent form of inherited juvenile macular degeneration. Fundus autofluorescence (FAF) is a widely available imaging technique which may aid in the diagnosis of Stargardt disease and is commonly used to monitor its progression. FAF imaging provides an in vivo assay of the retinal layers, but is only an indirect measure. Spectral-domain optical coherence tomography (SD-OCT), in contrast, provides three-dimensional visualization of ...

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    12. Lumedica Receives NIH Grant for Low-Cost OCT Angiography with Spectroscopic Contrast

      Lumedica Receives NIH Grant for Low-Cost OCT Angiography with Spectroscopic Contrast

      Lumedica Receives a 2021 NIH Grant for $259,079 for Low-Cost OCT Angiography with Spectroscopic Contrast. The principal investigator is William Brown. Below is a summary of the proposed work. The overall objective of this research project is to develop a low cost implementation of optical coherence tomography based angiography (OCTA). To meet this objective, we propose to incorporate several novel OCT components and techniques into a new OCTA instrument which can be applied in research studies and offers a pathway for commercialization and clinical use. This imaging system will use the agile design capabilities of our low cost OCT ...

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    13. New Jersey Institute of Technology Receives NIH Gran for Instrumentation for Optically Computed Compressive OCT for Ultra-High-Speed Phase-Resolved Dynamic Imaging

      New Jersey Institute of Technology Receives NIH Gran for Instrumentation for Optically Computed Compressive OCT for Ultra-High-Speed Phase-Resolved Dynamic Imaging

      New Jersey Institute of Technology Receives a 2020 NIH Grant for $230,250 for Instrumentation for Optically Computed Compressive OCT for Ultra-High-Speed Phase-Resolved Dynamic Imaging. The principal investigator is Xuan Liu. Below is a summary of the proposed work. The objective of this study is to investigate an optically computed compressive optical coherence tomography (OCC- OCT) technology for ultra-high speed phase-resolved dynamic imaging. Optical coherence tomography (OCT) is a cross- sectional imaging modality based on low coherence light interferometry. OCT has been used to image mechanical motion at cellular and tissue level for various biomedical applications. However, the state-of-the-art OCT ...

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    14. A look into stent‐related thrombus‐burden: Bivalirudin versus heparin

      A look into stent‐related thrombus‐burden: Bivalirudin versus heparin

      Use of optical coherence tomography (OCT) adds an assessment of thrombus burden remaining on stents after PCI for acute coronary syndromes. Potential variations in stent‐related thrombus burden can be documented by OCT as a function of peri‐procedural pharmacology supporting the use of OCT in future hypothesis testing. Bivalirudin remains a reliable and expensive alternative to heparin in cases of HIT or patients at high bleeding risk during transfemoral PCI.

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    15. Lumedica Receives Phase II SBIR-NSF Grant to develop dual-axis optical coherence tomography for deep tissue imaging

      Lumedica Receives Phase II SBIR-NSF Grant to develop dual-axis optical coherence tomography for deep tissue imaging

      Lumedica Inc., a privately held company, focused on creating low-cost imaging systems for medical and scientific use, has been awarded a $999,281 Small Business Innovation Research (SBIR) grant from the National Science Foundation. The grant enables further development of an optical coherence tomography imaging system that will penetrate skin and teeth more deeply to improve utility for the clinic. “We’re so grateful for the continued support and confidence on this project from the National Science Foundation,” said Principal Investigator and Lumedica CTO Dr. William Brown. “This award proves that we’re on the right track to create an ...

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    16. University of Southern California Receives NIH Grant for Role of Tonic Outer Hair Cell Motility in Cochlear Amplification

      University of Southern California Receives NIH Grant for Role of Tonic Outer Hair Cell Motility in Cochlear Amplification

      University of Southern California Receives a 2020 NIH Grant for $165,000 for Role of Tonic Outer Hair Cell Motility in Cochlear Amplification. The principal investigator is Hames Dewey Below is a summary of the proposed work. Mammalian hearing sensitivity depends on outer hair cells (OHCs), which change length and generate force to amplify sound-evoked vibrations within the cochlea. While it is often assumed that amplification depends on cycle-by-cycle OHC motility, the ability of this mechanism to operate at sufficiently high frequencies in vivo has been questioned, and exactly how OHCs interact with the surrounding organ of Corti structures to ...

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    17. Columbia University Receives NIH Grant for Instrumentation for Animal-Dedicated In Vivo Eye Imaging By Spectral Domain Optical Coherence Tomography.

      Columbia University Receives NIH Grant for Instrumentation for Animal-Dedicated In Vivo Eye Imaging By Spectral Domain Optical Coherence Tomography.

      Columbia University Receives a 2020 NIH Grant for $297,148 for Instrumentation for Animal-Dedicated In Vivo Eye Imaging By Spectral Domain Optical Coherence Tomography. The principal investigator is Janet Sparrow. Below is a summary of the proposed work. Columbia University has a large and vigorous vision research community supported by the National Eye Institute (NEI). The Department of Ophthalmology supports and develops clinically-oriented basic and translational research directed towards deciphering the genetic, biochemical and pathological determinants of vision threatening eye disease. This application proposes to advance ongoing NEI-funded research in the Department by the acquisition of shared animal-dedicated Bioptigen SD-OCT ...

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    18. University of Rochester Receives NIH Grant for Advanced Brain OCT Elastography

      University of Rochester Receives NIH Grant for Advanced Brain OCT Elastography

      University of Rochester Receives a 2020 NIH Grant for $421,880 for Advanced Brain OCT Elastography. The principal investigator is Kevin Parker. Below is a summary of the proposed work. Changes in the local and global mechanical properties of brain tissue associated with aging and neurodegenerative diseases has not been extensively studied and quantified. Pathology and autopsy case studies have provided some qualitative insight, and magnetic resonance elastography (MRE) studies have demonstrated some general patterns. However, current techniques require technical refinement and much remains to be elucidated about the relationship between the evolution of brain biomechanics and these complex processes ...

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    19. University of Illinois at Chicago Receives NIH Grant for Roles of Tau Oligomers in Alzheimer's Vasculopathy

      University of Illinois at Chicago Receives NIH Grant for Roles of Tau Oligomers in Alzheimer's Vasculopathy

      University of Illinois at Chicago Receives a 2020 NIH Grant for $389,542 for Roles of Tau Oligomers in Alzheimer's Vasculopathy. The principal investigator is James Lee. Below is a summary of the proposed work. Extracellular oligomeric tau (o-tau) and vascular deposition of o-tau has been observed in brains of Alzheimer's disease (AD) patients. In this project, we propose to examine how the direct interactions of o-tau with the basolateral side of human brain microvascular endothelial cells (HBMECs) impact their function, including oxidative stress, inflammation, adhesion molecule expression, membrane tether adhesion, and transendothelial migration of monocytes through activations ...

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    20. University of California at San Francisco Receives NIH Grant for Infrared Methods for Lesion Activity Assessment

      University of California at San Francisco Receives NIH Grant for Infrared Methods for Lesion Activity Assessment

      University of California at San Francisco Receives a 2020 NIH Grant for $45,564 for Infrared Methods for Lesion Activity Assessment. The principal investigator is Nai-Yaun Chang. Below is a summary of the proposed work. The overall objective of this proposed research is to develop methods for the clinical assessment of lesion structure and activity. Improved imaging technologies employing non-ionizing radiation will significantly improve caries diagnosis and management. It is not sufficient to simply detect carious lesions, methods are needed to assess the activity of the lesion and determine if chemical intervention is needed. The central hypothesis underlying this proposal ...

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    21. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives a 2020 NIH Grant for $486,444 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Joseph Carroll. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of treating these devastating diseases is a formidable task. Nevertheless, trials examining novel therapeutic strategies are underway. An important key to success in the early phases of such trials is selection of patients with reasonable therapeutic potential – for example, a ...

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    22. University of Texas Health Science Center in Houston ReceivesNIH Grant for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis

      University of Texas Health Science Center in Houston ReceivesNIH Grant for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis

      University of Texas Health Science Center in Houston Receives a 2020 NIH Grant for $398,791 for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis. The principal investigator is Shervin Assassi. Below is a summary of the proposed work. Systemic sclerosis (SSc-scleroderma) is an autoimmune disease leading to widespread fibrosis in skin and internal organs. Skin involvement is a prominent source of distress and morbidity in this disease. The modified Rodnan skin score (mRSS) as the current gold standard for assessment of skin thickening has limited accuracy, high inter-observer variability, requires extensive training which have ...

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    23. University of Southern California Receives NIH Grant for Comb Light Source/Imaging Spectrometer for Advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives NIH Grant for Comb Light Source/Imaging Spectrometer for Advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives a 2020 NIH Grant for $239,351 for Comb Light Source/Imaging Spectrometer for Advanced Spectral Domain Optical Coherence Tomography. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There is a growing interest in the development of functional imaging with Optical Coherence Tomography (OCT). Many of these approaches to functional imaging rely on the exquisite phase sensitivity of the OCT interferometer. These include well established techniques like Doppler OCT for measuring blood flow as well as emerging applications like OCT elastography for measuring mechanical properties, and Magnetomotive OCT and ...

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    24. General Electric Receives NIH Grant for Multi-Scale 3-D Image Analytics for High Dimensional Spatial Mapping of Normal Tissue

      General Electric Receives NIH Grant for Multi-Scale 3-D Image Analytics for High Dimensional Spatial Mapping of Normal Tissue

      General Electric Receives a 2020 NIH Grant for $750,000 for Multi-Scale 3-D Image Analytics for High Dimensional Spatial Mapping of Normal Tissue. The principal investigator is Yousef Al-Kofahi. Below is a summary of the proposed work. The overall goal of the proposed project is to develop open-source software and algorithms for 3-D reconstruction and multi-scale mapping of normal tissues. Another significant goal is to evaluate effects of aging and environmental factors on molecular and structural architecture of skin. We will leverage our mature (TRL8) technology for multiplexed 2-D imaging (Cell DIVE™), and our vast experience in 2-D image analytics ...

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