1. Articles in category: Funding

    1-24 of 934 1 2 3 4 ... 37 38 39 »
    1. New Jersey Institute of Technology Receives NIH Grant for Optically computed compressive OCT for ultra-high speed phase-resolved dynamic imaging

      New Jersey Institute of Technology Receives NIH Grant for Optically computed compressive OCT for ultra-high speed phase-resolved dynamic imaging

      New Jersey Institute of Technology Received a 2022 NIH Grant for $172,187 for Optically computed compressive OCT for ultra-high speed phase-resolved dynamic imaging. The principal investigator is Xuan Liu. Below is a summary of the proposed work. The objective of this study is to investigate an optically computed compressive optical coherence tomography (OCC- OCT) technology for ultra-high speed phase-resolved dynamic imaging. Optical coherence tomography (OCT) is a cross- sectional imaging modality based on low coherence light interferometry. OCT has been used to image mechanical motion at cellular and tissue level for various biomedical applications. However, the state-of-the-art OCT technology ...

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    2. National Eye Institute Receives Intramural 2022 NIH Grant for Evaluation of Visual Function in Animal Models

      National Eye Institute Receives Intramural 2022 NIH Grant for Evaluation of Visual Function in Animal Models

      National Eye Institute Receives Intramural 2022 NIH Grant for $201,678 for Evaluation of Visual Function in Animal Models. The principal investigator is Haohua Qian. Below is a summary of the proposed work. During the past year, we investigated functional regulation of an outer retina hyporeflective band on optical coherence tomography images. In particular, we studied the mechanisms of light-induced OCT responses in rodent eye and examined hypothesis that two light-evoked OCT indices in the outer retina, subretinal space elongation and hyporeflective band reflect two stages in an outer retinal signaling pathway. Human and animal retinal optical coherence tomography (OCT ...

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    3. Avinger Announces $7.6 Million Registered Direct Offering

      Avinger Announces $7.6 Million Registered Direct Offering

      Avinger, Inc. (NASDAQ:AVGR) (the "Company"), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced that it has entered into a definitive agreement with certain institutional investors for the issuance and sale in a registered direct offering of an aggregate of 7,600 shares of Series D convertible preferred stock (the "Preferred Stock") and warrants to purchase up to an aggregate of 16,150,000 shares of common stock for gross proceeds of $7.6 million. The shares of Preferred Stock will have a ...

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    4. University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary Motion in PCD

      University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary Motion in PCD

      University of Alabama at Birmingham Received a 2022 NIH Grant for $159,882 for Functional Categorization of Ciliary Motion in PCD. The principal investigator is George Solomon. Below is a summary of the proposed work. Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous disorder of motile cilia that results in progressive lung disease due to abrogated mucociliary clearance. While new understandings of the genetics have been helpful for clinical diagnostics, functional testing of cilia are needed to understand and predict phenotypic variation and response to therapy. Recent work in our laboratory has identified a link between ciliary genetics and novel ...

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    5. Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis

      Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis

      Massachusetts General Hospital Received a 2022 NIH Grant for $480,931 for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis. The principal investigator is Guillermo Tearney. Below is a summary of the proposed work. The diagnosis of most upper GI tract conditions is currently accomplished by upper endoscopy with biopsy (EGD). EGD is costly primarily because it requires conscious sedation, necessitating that procedures be conducted by physicians in a specialized endoscopy suite, and that patients take time away from work and family. Another limitation is sampling error - endoscopic biopsies are frequently random, resulting in many instances ...

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    6. University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

      University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

      University of Southern California Received a 2022 NIH Grant for $516,925 for Mechanisms of cochlear synaptopathy after noise or blast trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    7. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      Massachusetts Eye and Ear Infirmary Received a 2022 NIH Grant for $488,619 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

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    8. Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

      Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

      Washington University Received a 2022 NIH Grant for $492,557 for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart. The principal investigator is Chao Zhou. Below is a summary of the proposed work. Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subsequent sustained episode of ischemia. An emerging body of evidence demonstrated that neural regulated heart rate modulation confers cardiac preconditioning responses. Understanding the mechanism through model systems of preconditioning would help us identify the genes and proteins when ...

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    9. Medical College of Wisconsin Receives 2022 NIH Grant for Otitis Media Diagnosis and Treatment

      Medical College of Wisconsin Receives 2022 NIH Grant for Otitis Media Diagnosis and Treatment

      Medical College of Wisconsin received a 2022 NIH Grant for $576,383 for Otitis Media Diagnosis and Treatment. The principal investigator is Joseph Kerchner. Below is a summary of the proposed work. Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States (1,2), affects 90% of all children (3,4) and is the most common indication for antimicrobial therapy and surgery (5) in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity (1,3,6-30). OM continues ...

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    10. University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes

      University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes

      University of Southern California received a 2022 NIH Grant for $586,520 for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin growth in the middle ear which facilitates erosion of ...

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    11. Massachusetts General Hospital Receives NIH Grant for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives NIH Grant for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives a 2022 NIH Grant for $582,146 for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy. The principal investigator is Melissa Suter. Below is a summary of the proposed work. Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread offering patients little hope for cure (average 5-year survival rate < 15%). The U.S. Preventive Services Task Force recommends individuals at high risk of developing lung cancer undergo yearly screening with low dose computed tomography (LDCT). Screening ...

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    12. Perimeter Medical Imaging AI Announces Strategic Private Placement to Social Capital (C$43.4 million)

      Perimeter Medical Imaging AI Announces Strategic Private Placement to Social Capital (C$43.4 million)

      Perimeter Medical Imaging AI, Inc. (TSX-V:PINK)(OTC:PYNKF) (FSE:4PC) (“Perimeter” or the “Company”), a medical technology company driven to transform cancer surgery with ultra-high-resolution, real-time, advanced imaging tools to address high unmet medical needs, today announced that it has entered into a subscription agreement pursuant to which an affiliate of Social Capital Holdings Inc. (“Social Capital”) will make a strategic C$43.4 million investment in the Company. Jeremy Sobotta, Perimeter’s Chief Executive Officer stated, “We believe Social Capital’s investment marks a transformative, pivotal event for Perimeter that will help accelerate our growth. This strategic partnering ...

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    13. Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Glannaventa Receives a 2021 NIH NCI SBIR Grant for $399,331 for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. The principal investigator is John Black. Below is a summary of the proposed work. This year, over 22,000 women in the U.S. will be diagnosed with ovarian cancer (OvCa), and ~14,000 will die from this disease. Approximately 9,000 of these deaths occur from high-grade serous epithelial cancer (HGSC) primarily because of our inability to detect the disease in its early stages. OvCa accounts for 2.5% of all ...

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    14. Neurovascular Interventional Devices for Hemorrhagic Stroke - Global Market Analysis and Outlook 2020-2025 - ResearchAndMarkets.com

      Neurovascular Interventional Devices for Hemorrhagic Stroke - Global Market Analysis and Outlook 2020-2025 - ResearchAndMarkets.com

      DUBLIN--(BUSINESS WIRE)--Oct 8, 2021-- The "Global Neurovascular Interventional Devices for Hemorrhagic Stroke Market" report has been added to ResearchAndMarkets.com 's offering. This report covers the impact of COVID-19 on the neurovascular interventional devices for hemorrhagic stroke market, including a recent forecast from 2020 to 2025. COVID-19 has impacted leading competitors, such as Abbott, Boston Scientific, Cardinal Health, Penumbra, Stryker, Terumo, and others.

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    15. High-Risk, High-Reward grants awarded to three Stanford researchers

      High-Risk, High-Reward grants awarded to three Stanford researchers

      Winetraub’s research focuses on utilizing Optical Coherence Tomography and machine learning to image cancer non-invasively at a single-cell resolution. Currently, detecting most solid cancers and confirming the boundaries – or margins – of the tumor often entails analyzing chemically stained sections of tissue that are obtained via biopsy. Winetraub and members of the de la Zerda group at Stanford have recently developed a virtual version of this process. The NIH award will support further work on this project. “This imaging modality provides real-time diagnosis of tumor margins and invasiveness by scanning a large tissue area for residual cancer cells. Such information ...

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    16. University or Rochester Receives NIH Grant for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography

      University or Rochester Receives NIH Grant for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography

      University of Rochester Receives a 2021 NIH Grant for $51,036 for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography. The principal investigator is Gary Ge. Below is a summary of the proposed work. The rapidly advancing field of “elastography” has had some major successes in answering basic science questions and improving clinical diagnostics and therapies. For example, increased liver stiffness is strongly correlated with advanced liver disease such as fibrosis, increased aortic stiffness has been linked with cardiovascular disease, and multiple cancers can be assessed with viscoelastic heterogeneity. Other studies have used ...

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    17. Northwestern University Receives NIH Grant for Clinical glaucoma management enabled by visible-light OCT

      Northwestern University Receives NIH Grant for Clinical glaucoma management enabled by visible-light OCT

      Northwestern University Receives a 2021 NIH Grant for $698,124 for Clinical glaucoma management enabled by visible-light OCT. The principal investigator is Hao Zhang. Below is a summary of the proposed work. This collaborative technology focused project seeks to develop, characterize, and validate visible-light optical coherence tomography (vis-OCT) as a functional tool to transform the clinical management of glaucoma. We will address two unmet needs in clinical glaucoma diagnosis and detection of progression: (1) the ability to measure retinal sublayer structure and (2) to accurately assess local retinal hemoglobin oxygen saturation (sO2). The earliest structural changes in glaucoma are thought ...

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    18. University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      University of California at Irvine Receives a 2021 NIH Grant for $1,946,945 for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy. The principal investigator is Zhongping Chen. Below is a summary of the proposed work. Genitourinary Syndrome of Menopause (GSM) affects up to 50% of women and negatively affects their quality of life with regard to general health and sexual function. Hormone therapy is the most commonly performed procedure to supplement the natural estrogen, but health risk associated with long-term therapy exists. Recently, an alternative therapy has been proposed using fractional CO2 micro- ablation ...

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    19. Case Western Reserve University ReceivesNIH Grant for Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart disease

      Case Western Reserve University ReceivesNIH Grant for Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart disease

      Case Western Reserve University Receives a 2021 NIH Grant for $193,063 for Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart disease. The principal investigator is Stephanie Ford. Below is a summary of the proposed work. This proposal describes a five-year mentored research and training plan that will facilitate the development of Dr. Stephanie Ford, MD as an independent investigator in the pathogenesis of congenital heart disease. Building upon Dr. Ford’s background as a clinical neonatologist and a basic scientist, she will attain expertise in design of mouse studies, RNA-FISH, and epigenetic mechanisms. She will gain skills through ...

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    20. New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives a 2021 NIH Grant for $586,535 for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography. The principal investigator is Vivek Srinivasan. Below is a summary of the proposed work. Optical Coherence Tomography (OCT) has greatly advanced the diagnosis and management of many retinal diseases by enabling volumetric structural imaging of the retina. Usually, retinal OCT is performed at near- infrared (NIR) wavelengths, limiting both axial resolution and contrast for molecules that play a role in vision. Though NIR OCT defines biomarkers that quantify progression of dry age-related macular degeneration (AMD ...

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    21. Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives a 2021 NIH Grant for $582,395 for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging. The principal investigator is Nathan Doble. Below is a summary of the proposed work. The proposed design and construction of an optical coherence tomography (OCT) system, namely, a full-field (FF)-swept-source (SS)-OCT will allow rapid structural and functional measures of individual cone and rod photoreceptors (PRCs), the sub-retinal space (SRS) and retinal pigment epithelial (RPE) cells to an external light stimulus. Current OCT systems either have limited temporal resolution i.e. they are not fast enough ...

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    22. Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives a 2021 NIH Grant for $471,602 for OCT Angiography for Neovascular Age-related Macular Degeneration. The principal investigator is Yali Jia. Below is a summary of the proposed work. Neovascular age-related macular degeneration (AMD), characterized by the presence of choroidal neovascularization (CNV), accounts for the majority of AMD related vision loss. Invasive dye-based fluorescein angiography (FA) remains the gold standard for CNV detection. Using high-speed OCT systems, we have developed novel OCT angiography (OCTA) technologies to image CNV as well as vascular plexuses associated with AMD. Our recent clinical studies have demonstrated that (1 ...

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    23. Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hospital Receives a 2021 NIH Grant for $46,036 for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection. The principal investigator is Taylor Cannon. Below is a summary of the proposed work. Better imaging-based screening and surveillance methods stand to improve patient outcomes in cancers that are typically diagnosed at late stages, such as esophageal adenocarcinoma (EAC). Although success- ful proactive treatment options are available to patients diagnosed with low- or high-grade dysplasia, many at-risk patients are diagnosed at later stages with few effective treatment options, leading to high mortality rates. Dysplasia is diagnosed based ...

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