1. Articles in category: Funding

    1-24 of 386 1 2 3 4 ... 14 15 16 »
    1. University of Arizona Receives NIH Grant for Translational Studies and Clinical Pharmacology of New Drugs for Chemoprevention

      University of Arizona Receives NIH Grant for Translational Studies and Clinical Pharmacology of New Drugs for Chemoprevention

      University of Arizona Receives a 2014 NIH Grant for $294,662 for Translational Studies and Clinical Pharmacology of New Drugs for Chemoprevention. The principal investigator is Steven Stratton The program began in 2014 and ends in 2015 Below is a summary of the proposed work. Project 3 will test and clinically validate mechanisms and pharmacologic strategies explored in Projects 1-2, which target Akt-mTOR, AMPK-mTOR, and Fyn/RSK pathways. Advanced clinical/translational study of skin cancer carcinogenesis, biology, and pathophysiology will help reduce morbidity/ mortality, provide insight into keratinocyte signaling, and provide an easily-accessed human model of full-spectrum carcinogenesis for other ...

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    2. Columbia University Receives NIH Grant for Measures Of Human Receptor and Post Receptor Activity

      Columbia University Receives NIH Grant for Measures Of Human Receptor and Post Receptor Activity

      Columbia University Receives 2014 NIH Grant for $532,143 for Measures Of Human Receptor and Post Receptor Activity. The principal investigator is Donald Hood. The program began in 1991 and ends in 2016. Below is a summary of the proposed work. Our long-term objective has been to develop a set of noninvasive techniques for studying the human retina. By applying novel techniques and current theories of phototransduction to the full-field electroretinogram (ERG), we have successfully developed widely-used noninvasive techniques for studying the global activity of the rod and cone receptors, as well as the rod bipolar cells. These indices of ...

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    3. University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas

      University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas

      University of Washington Received a 2014 NIH Grant For $232,550 for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...

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    4. UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California at Irvine Received a 2014 NIH Grant for $598,705 for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging. The principal investigator is Zhongping Chen. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution ...

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    5. Johns Hopkins University Receives NIH Grant to investigate OCT To Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer

      Johns Hopkins University Receives  NIH Grant to investigate OCT To Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer

      Johns Hopkins University Receives a 2014 NIH Grant for $47,676 to investigate OCT To Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer. The principal investigator is Carmen Kut. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. In brain cancers such as gliomas, aggressive removal of the solid tumor through surgery is associated with improved overall survival. In fact, i has been shown that at least 78% of the tumor has to be removed to make a meaningful difference in the patient's survival. Current techniques for tumor removal ...

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    6. Stanford University Receives a NIH grant for Enhanced Clinical Diagnosis of Early Osteoarthritis

      Stanford University Receives a NIH grant  for Enhanced Clinical Diagnosis of Early Osteoarthritis

      Stanford University Receives a 2014 NIH grant for $460,742 for Enhanced Clinical Diagnosis of Early Osteoarthritis. The principal investigator was Constance Chu. The program began in 2005 and ends in 2016. Below is a summary of the proposed work. Osteoarthritis is a leading cause of disability, and a major public health issue. Progressive loss of articular cartilage due to injury and degeneration are important etiological factors in the development of osteoarthritis. While laboratory studies show a potential to reverse pathological changes in articular cartilage prior to breakdown of the articular surface, a major barrier to clinical translation of these ...

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    7. Quantitative comparison of analysis methods for spectroscopic optical coherence tomography: reply to comment

      Quantitative comparison of analysis methods for spectroscopic optical coherence tomography: reply to comment

      We reply to the comment by Kraszewski et al on “Quantitative comparison of analysis methods for spectroscopic optical coherence tomography.” We present additional simulations evaluating the proposed window function. We conclude that our simulations show good qualitative agreement with the results of Kraszewski, in support of their conclusion that SOCT optimization should include window shape , next to choice of window size and analysis algorithm.

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    8. University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      University of Pittsburgh Receives a 2014 NIH Grant for $726,299 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2000 and ends in 2019. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of utmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project is to precisely ...

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    9. Johns Hopkins University Receives a 2014 NIH Grant for 3D Segmentation and Registration of Macular SD-OCT for Applications in Multiple Sclerosis

      Johns Hopkins University Receives a 2014 NIH Grant for 3D Segmentation and Registration of Macular SD-OCT for Applications in Multiple Sclerosis

      Johns Hopkins University Receives a 2014 NIH Grant for $387,284 for 3D Segmentation and Registration of Macular SD-OCT for Applications in Multiple Sclerosis. The principal investigator is Jerry Prince. Below is a summary of the proposed work. Vision is compromised in at least 55% of multiple sclerosis (MS) patients and may represent the very first manifestation of disease onset. Spectral domain optical coherence tomography (SD-OCT) enables in-vivo, high-resolution studies of the retina, and is increasingly being used as a biomarker in neurodegenerative diseases. SD-OCT has provided phenotypical measurements of the retinal nerve fiber layer, ganglion cell layer, and overall ...

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    10. Wasatch Photonics Receives an NIH SBIR Grant for Cost-Effective MHz Rate Optical Coherence Tomography for Biomedical Applications

      Wasatch Photonics Receives an NIH SBIR Grant for Cost-Effective MHz Rate Optical Coherence Tomography for Biomedical Applications

      Wasatch Photonics Receives an NIH SBIR Grant for $207,045 for Cost-Effective MHz Rate Optical Coherence Tomography for Biomedical Applications. The principal investigator is Roman Kuranov. The program began in 2014 and ends in 2015. Below is a summary of the proposed work. During this SBIR Phase I project we propose to build and test in phantoms a prototype of an innovative cost-effective Optical Coherence Tomography (OCT) system with a 10X increase in acquisition rate compared to commercially available systems. Further development may add an additional 10X increased acquisition rate for a total of 100X. Current market demand for Mega ...

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    11. UCSF received a NIH Grant for Clinical Assessment of Tooth Demineralization & Remineralization with PS-OCT

      UCSF received a NIH Grant for Clinical Assessment of Tooth Demineralization & Remineralization with PS-OCT

      University of California at San Francisco received a 2014 NIH Grant for $333,825 for Clinical Assessment of Tooth Demineralization & Remineralization with PS-OCT. The principal investigator is Daniel Fried. The program began in 2006 and ends in 2015. Below is a summary of the proposed work. The overall objective of this proposed research is to develop polarization sensitive optical coherence tomography (PS-OCT) as a non-invasive optical device for the accurate and early clinical assessment of tooth demineralization and remineralization. The central hypothesis underlying this proposal is that the depth-resolved changes in the magnitude of light scattering of dental hard tissues ...

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    12. Cleveland Clinic / CWRU NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic / CWRU NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic/ Case Western Reserve University Receiver 2014 NIH Grant for $203,124 for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery. The principal investigator is Justis Ehlers. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Optical coherence tomography (OCT) has revolutionized the management of ophthalmic diseases with the precise anatomic information it provides with non-invasive imaging. The high-resolution cross-sectional tissue details make OCT a natural complement to ophthalmic surgery. Intraoperative OCT (iOCT) has the potential to provide real-time feedback to surgeons thus improving surgical care and outcomes. This research activity will ...

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    13. Yale University Receives NIH Grant for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers

      Yale University Receives  NIH Grant  for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers

      Yale University Receives 2014 NIH Grant for $209,850 for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers. The principal nvestigator is Michael Choma. Below is a summary of the proposed work. Confocal microscopy uses geometric principles to generate cross-sectional images of scattering biological tissue. Traditional reflectance confocal microscopes use serial pixel acquisition, thereby limiting acquisition speeds. Parallelization of pixel acquisition would dramatically increase imaging speeds and enable the study of new kinds of physiology. For example, massively parallelized reflectance confocal microscopy would be invaluable in the emerging field of cilia-driven mucus physiology in the respiratory system. Indeed, in terms ...

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    14. Massachusetts General Hospital Receives NIH Grant for The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives 2014 NIH Grant For $1,449,151 for The Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly ...

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    15. Dynamics of a short cavity swept source OCT laser

      Dynamics of a short cavity swept source OCT laser

      We investigate the behaviour of a short cavity swept source laser with an intra cavity swept filter both experimentally and theoretically. We characterise the behaviour of the device with real-time intensity measurements using a fast digital oscilloscope, showing several distinct regimes, most notably regions of mode-hopping, frequency sliding mode-locking and chaos. A delay differential equation model is proposed that shows close agreement with the experimental results. The model is also used to determine important quantities such as the minimum and maximum sweep speeds for the mode-locking regime. It is also shown that by varying the filter width the maximum sweep ...

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    16. University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for $188,364 for Computational Ophthalmology. The principal investigator is Linda Zangwill. The program began in 2014 and ends in 2014. Below is a summary of the proposed work. COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization ...

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    17. University of California at San Diego receives NIH Grant for Studying Animal Structure and Function

      University of California at San Diego receives NIH Grant for Studying Animal Structure and Function

      University of California at San Diego received a 2014 NIH Grant for $167,628 for Animal Structure and Function. The principal investigator is Dirk-Uwe Bartsch. The program began in 2014 and ends in 2015. Below is a summary of the proposed work. The Animal Structure and Function Module will provide new centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The recent growth in the number of faculty in the Department of Ophthalmology conducting animal structure ...

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    18. Physical Sciences Receives NIH Grant for Optical Coherence Tomography Based on Freeze Drying Microscopy

      Physical Sciences Receives NIH Grant for Optical Coherence Tomography Based on Freeze Drying Microscopy

      Physical Sciences Incorporated Received a 2014 NIH Grant for $538,335 for Optical Coherence Tomography Based on Freeze Drying Microscopy. The principal investigator is Mircea Mujat. The program began in 2009 and ends in 2015. Below is a summary of the proposed work. Physical Sciences Inc. (PSI), in collaboration with the University of Connecticut (UConn), proposes to develop the 2nd generation of an advanced 3D freeze-drying microscopy (FDM) system to advance the understanding of freeze-drying and to enable the development of efficient commercial freeze drying processes. During the Phase I program PSI demonstrated the application of Optical Coherence Tomography (OCT ...

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    19. Baylor College of Medicine Receives NIH Grant for Studying Biomechanics of Early Mammalian Cardiogenesis

      Baylor College of Medicine Receives NIH Grant for Studying Biomechanics of Early Mammalian Cardiogenesis

      Baylor College of Medicine Received a 2014 NIH Grant for $378,647 for Biomechanics of Early Mammalian Cardiogenesis. The principal investigator is Irina Larina. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Congenital heart defects are among the most common birth defects and the leading cause of death in children born with congenital defects. Understanding how the early embryonic heart functions and what regulatory mechanisms are involved in early cardiogenesis is highly important for advancement of heart defects research. Biomechanical stimuli, including blood flow and heart contraction, are important regulators of ...

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    20. University of Houston Receives NIH Grant for Optical Coherence Elastography of the Cornea

      University of Houston Receives NIH Grant  for Optical Coherence Elastography of the Cornea

      University of Houston Received a 2014 NIH Grant for $388,129 for Optical Coherence Elastography of the Cornea. The principal investigator is Kirill Larin. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement ...

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    21. MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Received a 2014 NIH Grant for $302,576 for Optical Biopsy Using Optical Coherence Tomography. THe principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

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    22. Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography

      Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography

      Yale University Receivesd a 2014 NIH Grant for $201,881 for Development of a New Light Sources for Parallel Optical Coherence Tomography. The principal investigator is Michel Choma. The program began in 2013 and ends in 2015. Below is a summary of the proposed work. The ability of optical coherence tomography (OCT) to perform high-speed, micron-scale, cross-sectional imaging has transformed ophthalmic medicine and has the potential to transform cardiovascular, gastrointestinal, pulmonary, and dermatological medicine. Current OCT systems use raster scanning, a serial method for acquiring depth reflectivity profiles at different locations on a sample. Shifting the paradigm fro serial to ...

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    23. UIUC Receives NIH Grant for Partnership for Primary Care Imaging

      UIUC Receives NIH Grant for Partnership for Primary Care Imaging

      University of Illinois at Urbana Champaign Received a 2014 NIH Grant for $933,337 for Partnership for Primary Care Imaging. The principal investigator is Stephen Boppart. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Primary Care Medicine, including Family Practice and Pediatrics, has traditionally relied on physical exam skills and simplistic instruments for critical diagnostic decision making, monitoring, and referral to medical specialists. The otoscope and ophthalmoscope are two historical and ubiquitous instruments that largely only illuminate and magnify tissue surfaces in the ear and eye, respectively. This Partnership will develop ...

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    24. UC Riverside Receives a 2014 NIH Grant for Studying Optical Detection of the Pre-Seizure State

      UC Riverside Receives a 2014 NIH Grant for Studying Optical Detection of the Pre-Seizure State

      UC Riverside Received a 2014 NIH Grant for $437,523 for Studying Optical Detection of the Pre-Seizure State. The principal investigator is Devin Binder. The program began in 2-012 and ends in 2016. Below is a summary of the proposed work. Reliable means of detecting changes which occur during the "pre-seizure state" could serve as a method of seizure prediction, a benchmark in epilepsy research (NIH Curing Epilepsy Conferences, 2000 and 2007). Our preliminary data indicate pre-seizure constriction in brain extracellular space (ECS) accompanied by reduction in near-infrared (NIR) optical scattering prior to detection of seizure by electroencephalography (EEG). The ...

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