1. Articles in category: Funding

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    1. University of Alabama Receives NIH Grant for In Vivo Ultrastructure of Chorioretinal Disease

      University of Alabama Receives NIH Grant for In Vivo Ultrastructure of Chorioretinal Disease

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $367,500 for In Vivo Ultrastructure of Chorioretinal Disease. The principal investigator is Yuhua Zhang. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is a leading cause of vision loss in more than 10 million older Americans. For decades, AMD has been characterized by accumulation of extracellular lesions called drusen on the inner surface of Bruch's membrane (BrM), posterior to the retinal pigment epithelium (RPE), in a compartment called the sub-RPE space. Drusen are now ...

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    2. UC Davis Receives NIH Grant for Studying Properties of Photoreceptors and Muller Cells Investigated with AO-OCT

      UC Davis Receives NIH Grant for Studying Properties of Photoreceptors and Muller Cells Investigated with AO-OCT

      University of California Davis Receives a 2019 NIH Grant for $245,479 for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT. The principal investigator is Ravi Jonnal. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The research proposed for this award will examine functional and structural properties of single cells in the human retina. The three Aims will link the candidate's scientific background and career plans to study the human retina using a combination of adaptive optics (AO) and optical coherence tomography (OCT) which provide high lateral and high ...

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    3. Dyad Medical Incorporated Receives NIH Grant for Software for OCT Analysis of Vascular Stents

      Dyad Medical Incorporated Receives NIH Grant for Software for OCT Analysis of Vascular Stents

      Dyad Medical Incorporated Receives a 2019 NIH Grant for $1,265,906 for Software for OCT Analysis of Vascular Stents. The principal investigator is Ronny Shalev The program began in 2017 and ends in 2021. Below is a summary of the proposed work. Dyad Medical, Inc. will create intravascular Optical Coherence Tomography (IVOCT) software for clinical, live time determination of stent apposition and for offline analysis of stent implantation. Every year, 100s of thousands of patients in the US are treated with intravascular stents creating an opportunity for both solutions. Although advancements such as drug eluting metal stents hinder restenosis ...

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    4. Iowa City VA Medical Center Receives NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging.

      Iowa City VA Medical Center Receives NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging.

      Iowa City VA Medical Center Receives a 2019 NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury, and from idiopathic causes. Currently, the diagnosis of papilledema and its severity are assessed by direct funduscopic observation or digital fundus photographs using a six-stage grading scale. The scale ...

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      Mentions: Mona K. Garvin
    5. Johns Hopkins Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosis

      Johns Hopkins Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosis

      Johns Hopkins University Receives a 2019 NIH Grant for $628,385 for Imaging Neurodegeneration in Multiple Sclerosis. The principal investigator is Peter Calabresi. The program began in 2013 and ends in 2023. Below is a summary of the proposed work. One of the significant challenges facing treatment of people with multiple sclerosis (MS) is determining their individual likelihood of progression, as this information would significantly influence the type of therapy selected. Thus, developing specific tools to monitor and predict progression is critical to better manage patient care and to understand mechanisms of disease. We have been developing a multi-faceted approach ...

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    6. Georgia Institute of Technology Receives NIH Grant for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology

      Georgia Institute of Technology Receives NIH Grant for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology

      Georgia Institute of Technology Receives a 2019 NIH Grant for $182,900 for Stimulated Raman Scattering Spectroscopic Optical Coherence Tomography (SRS-SOCT) for Label-Free Molecular Imaging of Brain Tumor Pathology. The principal investigator is Francisco Robels. The program began in 2018 and ends in 2021. Below is a summary of the proposed work. The extent of resection of brain tumors is one of the most important factors associated with prolonged survival for patients with brain cancer. Unfortunately, achieving complete resection of the preoperatively-defined tumor region remains a significant clinical challenge. This is due, in part, to the lack of intraoperative tools ...

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    7. UCLA Receives NIH Grant for Vitroretinal Surgery via Rogbotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      UCLA Receives NIH Grant for Vitroretinal Surgery via Rogbotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      University of California at Los Angeles Receives a 2019 NIH Grant for $439,347 for Vitroretinal Surgery via Rogbotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality. The principal investigator is Jean-Pierre Hubschman. The program began in 2019 and ends in 2024. Below is a summary of the proposed work. The aims of the present proposal are to extend our work with the Intraocular Robotic Interventional and Surgical System (IRISS) and augment it for teleoperated vitreoretinal surgery. Although novel technologies such as intraoperative optical coherence tomography (i-OCT) have been developed, vitreoretinal surgeons still lack critical information ...

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    8. OSHU Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      OSHU Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health & Science University Receives a 2019 NIH Grant for $496,687 for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the eye, including the cornea, conjunctiva, sclera, anterior chamber, iris, and crystalline lens. Anterior segment OCT is already widely used in ophthalmology. But ...

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    9. Duke University Receives NIH Grant for Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young Children

      Duke University Receives NIH Grant for Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young Children

      Duke University Receives a 2019 NIH Grant for $230,682 for Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young Children. The principal investigator is Sina Farsiu. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. Eye diseases in young children, if not detected and treated early, can lead to serious vision loss and even blindness. We have pioneered development of handheld spectral domain optical coherence tomography (HH- SDOCT) imaging systems to provide 3-D visualization of intra-retinal structures. Our previous studies based on HH-SDOCT of neonatal retina have already provided unique ...

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    10. Lightoptech Corporation Receives NIH Grant for Towards In Vivo High-Definition 3D Corneal Imaging

      Lightoptech Corporation Receives NIH Grant for Towards In Vivo High-Definition 3D Corneal Imaging

      Lightoptech Corporation Receives a 2019 NIH Grant for $225,000 for Towards In Vivo High-Definition 3D Corneal Imaging. The principal investigator is Cristina Canavesi. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The cornea, the outermost window of our visual system, is vulnerable to various types of infections and diseases. Corneal disease is one of the leading causes of visual deficiency and blindness.!There are nearly 5 million bilaterally corneal blind persons worldwide, and an estimated 23 million people affected by unilateral corneal blindness globally. In a conservative estimate, corneal diseases ...

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    11. University of Alabama Receives NIH Grant for The Mechanisms Underlying Abnormal Mucus and Its Clearance in the Cystic Fibrosis Rat

      University of Alabama Receives NIH Grant for The Mechanisms Underlying Abnormal Mucus and Its Clearance in the Cystic Fibrosis Rat

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $135,841 for The Mechanisms Underlying Abnormal Mucus and Its Clearance in the Cystic Fibrosis Rat. The principal investigator is Susan Birket. The program began in 2017 and ends in 2022. Below is a summary of the proposed work. Abnormal mucociliary clearance (MCC) is a critical component of cystic fibrosis (CF) lung disease, especially in the presence of infection; however, the mechanisms responsible for the defect are not well understood. Until recently, evaluation of this question has been primarily limited to cell culture models which do not replicate the ...

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    12. Cornell University Receives NIH Grant for Three-Dimensional Mechano-Microscopy of the Stem Cell Niche

      Cornell University Receives NIH Grant for Three-Dimensional Mechano-Microscopy of the Stem Cell Niche

      Cornell University Receives a 2019 NIH Grant for $190,047 for Three-Dimensional Mechano-Microscopy of the Stem Cell Niche. The principal investigator is Steven Adie. The program began in 2018 and ends in 2021. Below is a summary of the proposed work. Biophysical properties of cellular microenvironments can act to direct the self-renewal and differentiation fate outcomes of stem cells in multiple tissue types. As an example, the stem cells resident in skeletal muscles (MuSCs, also called satellite cells) are highly sensitive to elasticity of their surrounding “niche” microenvironment. In culture models, elastic substrates corresponding to the more stiff microenvironments observed ...

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    13. University of Alabama Receives NIH Grant for Functional Categorization of Ciliary Motion in PCD

      University of Alabama Receives NIH Grant for Functional Categorization of Ciliary Motion in PCD

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $159,882 for Functional Categorization of Ciliary Motion in PCD. The principal investigator is George Solomon. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous disorder of motile cilia that results in progressive lung disease due to abrogated mucociliary clearance. While new understandings of the genetics have been helpful for clinical diagnostics, functional testing of cilia are needed to understand and predict phenotypic variation and response to therapy. Recent work in our laboratory ...

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    14. Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives 2019 NIH Grant for $165,376 for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology. The principal investigator is Eric Osborn. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Dr. Eric Osborn is an early career faculty member at Beth Israel Deaconess Medical Center (BIDMC) and Massachusetts General Hospital (MGH), and an Instructor in Medicine at Harvard Medical School, Boston, Massachusetts. He is a graduate of the MD-PhD program at Harvard Medical School and Massachusetts Institute of Technology, and has completed clinical training in medicine and ...

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    15. Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization

      Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization

      Baylor College of Medicine Receives a 2019 NIH Grant for $657,043 for In Vivo Analysis of Mammalian Fertilization. The principal investigator is Irina Larina. The program began in 2019 and ends in 2022. Below is a summary of the propose work. Estrous cycle, ovulation, fertilization, and pre-implantation pregnancy are fundamental reproductive processes of clinical importance. While research has shed light on the cellular and molecular mechanisms mediating these events, much of these data are derived from static histological analysis, low-resolution visualizations, and studies of invertebrate models (e.g. sea urchin). Therefore, any conclusions regarding mammalian fertilization, which takes place ...

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    16. University of Miami Receives NIH Grant for Endothelium/Deschmet's Membrane Complex Optical Tomography

      University of Miami Receives NIH Grant for Endothelium/Deschmet's Membrane Complex Optical Tomography

      University of Miami Receives a 2019 NIH Grant for $219,654 for Endothelium/Deschmet's Membrane Complex Optical Tomography. The principal investigator is Abou Shousha. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. More than 50% of corneal transplants, the most common form of solid organ transplantation, are performed to restore vision lost secondary to corneal endothelial failure. More than 25% of those transplants will eventually fail and endothelial cell rejection leading to failure is the single most important cause. The key to protec the endothelium is the early and accurate ...

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    17. MEEI Receives NIH Grant for Measuring and Modeling The Cochlear Motions that Drive The Inner and Outer Hair Cells and Produce Otoacoustic Emissions

      MEEI Receives NIH Grant for Measuring and Modeling The Cochlear Motions that Drive The Inner and Outer Hair Cells and Produce Otoacoustic Emissions

      Massachusetts Eye and Ear Infirmary Receives a 2019 NIH Grant for $540,156 for Measuring and Modeling The Cochlear Motions that Drive The Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. The program began in 2007 and ends in 2022. Below is a summary of the propose work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in ...

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    18. MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.

      MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.

      Massachusetts General Hospital Receives a 2019 NIH Grant for $729,778 for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management. The principal investigator is Guillermo Tearney. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. Management of CAD is hindered by our inability to investigate fundamental pathobiologic processes that lead to individual coronary plaque progression, destabilization, and adverse clinical events. A critical mechanism responsible for plaque behavior is local endothelial shear stress (ESS), the frictional force of blood flowing across the endothelium, which is governed by the artery’s ...

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    19. University of Houston Receives NIH Grant for Optical Coherence Tomography to Study Effects of Poly-Drug Exposure of Fetal Brain Development

      University of Houston Receives NIH Grant for Optical Coherence Tomography to Study Effects of Poly-Drug Exposure of Fetal Brain Development

      University of Houston Receives 2019 NIH Grant for $345,824 for Optical Coherence Tomography to Study Effects of Poly-Drug Exposure of Fetal Brain Development. The principal investigator is Kirill Larin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The overall objective of this study is to develop an optical coherence tomography (OCT) based high- resolution mouse embryonic brain imaging and analysis approach, and to use this method in correlation with molecular analysis to understand the interplay between ethanol (EtOH) and nicotine (NIC) effects on embryonic brain development. Maternal exposures to these ...

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    20. Researchers design technology that sees nerve cells fire

      Researchers design technology that sees nerve cells fire

      Researchers at Stanford University, Palo Alto, California, have created a noninvasive technology that detects when nerve cells fire based on changes in shape. The method could be used to observe nerve activity in light-accessible parts of the body, such as the eye, which would allow physicians to quantitatively monitor visual function at the cellular level. The study was published in the journal Light: Science and Applications . The work was funded by the National Eye Institute, part of the National Institutes of Health. When nerves fire, there's a change in the electrical potential (trans-membrane voltage) in the cell. Current techniques ...

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    21. Eunice Kennedy Shriver National Institute of Child Health & Human Development receives a NIH Grant for Quantitative Biophontonics for Tissue Characterization and Function

      Eunice Kennedy Shriver National Institute of Child Health & Human Development receives a NIH Grant for Quantitative Biophontonics for Tissue Characterization and Function

      Eunice Kennedy Shriver National Institute of Child Health & Human Development receives a 2018 NIH Grant for $741,019 for Quantitative Biophontonics for Tissue Characterization and Function. The principal investigator is Amir Gandjbakache. Below is a summary of the proposed work. Monitoring the placenta oxygenation is critical to ensure a healthy pregnancy outcome. Abnormalities in placental oxygenation has been associated with preeclampsia and intrauterine growth restriction, fetal hypoxia, asphyxia, and cerebral palsy. Currently, there are no patient-friendly devices to measure the oxygenation of the anterior placenta. Therefore, it is crucial to have a quantitative understanding of placental oxygenation. Functional Near Infrared ...

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    22. Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System

      Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System

      Notal Vision, Ltd., ("Notal") a privately-held ophthalmic diagnostic services company, focused on advancing eye care by extending ophthalmic disease management from the clinic to the home, has announced the U.S. Food and Drug Administration (FDA) granted the Notal Vision Home-based Optical Coherence Tomography (OCT) System with "Breakthrough Device" designation for the agreed upon indications for use. This designation indicates that FDA intends to provide interactive and timely communication with the sponsor during device development and throughout the review process for various types of premarket submissions. FDA's Breakthrough Devices Program was established in late 2016 to help patients gain ...

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    23. Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. Ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.

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    24. PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare, a medical device company headquartered in Champaign, Illinois, received a $2.1 million award through the National Institute of Health (NIH) Phase llb Small Business Innovation Research (SBIR) program. The National Institute of Deafness & Communications Disorders (NIDCD), part of the NIH, is funding this award. The NIDCD conducts and supports research in the normal and disordered processes of hearing, balance, taste, smell, voice, speech, and language. In fiscal years 2015 and 2016 PhotoniCare was awarded SBIR Phase ll funding from the NIDCD. The SBIR program is the mechanism by which the NIH and other Federal agencies bring innovative solutions ...

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