1. Articles in category: Funding

    1-24 of 442 1 2 3 4 ... 17 18 19 »
    1. University of Alabama Receives NIH Grant for Developing a Clinical and Translation Core Related to Cystic Fibrosis

      University of Alabama Receives NIH Grant  for Developing a Clinical and Translation Core Related to Cystic Fibrosis

      University of Alabama Receives a 2015 NIH Grant for $193,380 for Developing a Clinical and Translation Core related to Cystic Fibrosis. The principal investigator is steven Rowe. The program began in 2015 and ends in 2016. Below is a summary of the proposed work. Numerous investigators within the current P30 application have indicated a need for 1) primary human airway epithelial cells (from lung transplantation) or nasal epithelial cells from CF and non-CF individuals; 2) measurements of the functional anatomy of respiratory epithelia that track airway surface liquid homeostasis, ciliary beating, and mucociliary transport; or 3) CFTR bioelectric assays ...

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    2. University of Maryland Receives NIH Grant for Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds

      University of Maryland Receives NIH Grant for Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds

      University of Maryland Receives a 2015 NIH Grant for $320.744 for Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds. The principal investigator is Yu Chen. Below is a summary of the propose work. Three-dimensional (3D) cell-based tissue grafts have been increasingly useful in tissue engineering and regenerative medicine. A critical building block in tissue engineering is the scaffold which can act as the supporting medium to deliver cell populations and induce the ingrowth of vessels and surrounding tissues. Therefore, it is necessary to develop tools to characterize the architecture of the scaffold. In addition, to study ...

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    3. Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Received a 2015 NIH Grant for $780,355 for Intracoronary Imaging of Plaque Collagen in Patients. The principal investigator is Seemantini Nadkarni. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The goal of this proposal is to develop and validate an intracoronary imaging device for the assessment of plaque collagen content and architecture in patients. Acute myocardial infarction (AMI), caused by the rupture of unstable plaque, is the leading cause of death worldwide. Collagen and vascular smooth muscle cells (vSMCs) together impart mechanical stability to a plaque, and ...

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    4. University of Iowa Receives NIH grant for 3D Image Analysis Approach to Determine Severity and Cause of Optical Nerve Edema

      University of Iowa Receives  NIH grant for 3D Image Analysis Approach to Determine Severity and Cause of Optical Nerve Edema

      University of Iowa Received a 2015 NIH grant for $332,955 for 3D Image Analysis Approach to Determine Severity and Cause of Optical Nerve Edema. The principal investigator is Mona Garvin. The program began in 2013 and ends in 12018. Below is a summary of the proposed work. Currently, the clinical assessment of optic nerve swelling is limited by the subjective ophthalmoscopic evaluation by experts in order to diagnose and differentiate the cause of the optic disc edema. The long-term goal of our research effort is to develop automated 3D image-analysis approaches for the identification of an optimal set of ...

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    5. Massachusetts General Hospital Receives NIH Grant for OCTOLOGY: Histology Using Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for OCTOLOGY: Histology Using Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2015 NIH Grant for $217,500 for OCTOLOGY: Histology Using Optical Coherence Tomography. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. While histology remains the gold standard for assessing human neuroanatomy, the procedures for sectioning and hand mounting tissue for microscopic imaging are not substantially different than they were 100 years ago. These steps introduce irremediable distortions into the tissue sections making it difficult or impossible to align sections with suffiient accuracy to create 3D histological volumes at the micron ...

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    6. University of Maryland Receives NIH Grant for Identification of AF Ablation Targets via a Steerable Actuated Catheter

      University of Maryland Receives NIH Grant for Identification of AF Ablation Targets via a Steerable Actuated Catheter

      University of Maryland Receives a 2015 NIH Grant for $222,800 for Identification of AF Ablation Targets via a Steerable Actuated Catheter. The principal investigator is Jaydev Desai. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. Atrial fibrillation (AF) is the most common cardiac arrhythmia and has high patient morbidity, increases mortality two-fold, and increases health care costs. Each year, about 200,000 Americans are newly diagnosed with AF with a prevalence of several million in the U.S. alone. In the majority of cases, AF has been shown to originate ...

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    7. Columbia University Receives NIH Grant for Structural and Functional Progression of Glaucomatous Damage to the Macula

      Columbia University Receives NIH Grant for Structural and Functional Progression of Glaucomatous Damage to the Macula

      Columbia University Receives 2015 NIH Grant for $400,000 for Structural and Functional Progression of Glaucomatous Damage to the Macula. The principal investigator is Carlos Gustavo De Moraes. The program began in 20125 and ends in 2018. Below is a summary of the propose work. There is compelling evidence that glaucomatous damage to the macula occurs even in early stages of the disease. The macula comprises about 30% of all retinal ganglion cells and its information corresponds to over 50% of the visual cortex. However, glaucomatous damage to the macula is often missed in clinical practice. Some of the reasons ...

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    8. University of California Irvine Receives NIH Grant for Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California Irvine Receives NIH Grant for Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California Irvine Receives a 2015 NIH Grant for $664,990 for Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging. The principal investigator is Zhongping Chan The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution of ...

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    9. Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging

      Massachusetts General Hospital Receives a 2015 NIH Grant for $285,859 for High Resolution Optical Imaging. The principal investigator is David Boas. The program began in 2015 and ends in 2015. Below is a summary of the proposed work.

      This core will support the theme of functional coupling between glial, endothelial, and neuronal cells by using both in vivo and in vitro novel optical imaging to dissect the mechanisms of brain plasticity after cerebral ischemia . Novel optical imaging technologies have unique capability to measure the dynamics of glia, endothelium, and neurons as well as hemodynamic, metabolic, and electrophysiologic responses upon ...

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    10. UC Irvine Receives NIH Grant for Low-Cost Simple Oral cancer Screening Device for Low-Resource Settings.

      UC Irvine Receives NIH Grant  for Low-Cost Simple Oral cancer Screening Device for Low-Resource Settings.

      University of California Irvine Receives a 2015 NIH Grant for $25,263 for Low-Cost Simple Oral cancer Screening Device for Low-Resource Settings. The principal investigator is Petra Wilder-Smith. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. Our long-term goal is to develop an inexpensive, simple, portable means of screening for oral cancer in the field by basic level healthcare workers in low-resource environments. Screening will identify whether a person needs to travel to a center with higher levels of expertise in oral cancer for further tests and potential cancer therapy. The ...

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    11. Boston University Receives NIH Grant for Visualizing Cortical Microstructures by Optical Coherence Tomography

      Boston University Receives NIH Grant for Visualizing Cortical Microstructures by Optical Coherence Tomography

      Boston University Receives a 2015 NIH Grant for $259,490 for Visualizing Cortical Microstructures by Optical Coherence Tomography. The principal investigator is Katehleen Rockland. The program began in 2015 and ends in 2017. Below is a summary of the propose work.

      Area-specific differences in microstructure and cell-type distribution are well-established across cortical regions in the human brain; and specific morphological changes have been identified in different disease conditions, such as cortical thinning or, at a finer level of resolution, changes in specific pyramidal or non-pyramidal cell populations. These data, however, are based on relatively small sample sizes and can be ...

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    12. University of Texas, Austin Receives NIH Grant for Optical Imaging of Baseline Blood Flow and Oxygenation During Stroke

      University of Texas, Austin Receives NIH Grant for Optical Imaging of Baseline Blood Flow and Oxygenation During Stroke

      University of Texas, Austin Receives a 2015 NIH Grant for $465,127 for Optcial Imaging of Baseline Blood Flow and Oxygenation During Stroke. The principal investigator is Andrew Dunn. The program began in 2010 and ends in 2019. Below is a summary of the proposed work. Quantitative imaging of cerebral blood flow is essential in preclinical stroke studies for monitoring the efficacy of potential treatments and for understanding the role of vascular reorganization in functional recovery. Similarly, real-time imaging of blood flow is crucial during neurovascular surgery in humans, where intraoperative visualization of vascular patency and tissue perfusion are needed ...

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    13. National Research Council of Canada Receives NIH Grant for Validating OCT and Raman Spectrosopy for Assessment of Tooth De/Remineralization

      National Research Council of Canada Receives NIH Grant for Validating OCT and Raman Spectrosopy for Assessment of Tooth De/Remineralization

      National Research Council of Canada Receives NIH Grant for $208,382 for Validating OCT and Raman Spectrosopy for Assessment of Tooth De/Remineralization. The principal investigator is Michale Sowa. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Dental caries continues to be prevalent in children and youth, with significant oral health disparities existing in some population groups. This disease arises when the balance between pathological factors (e.g. cariogenic bacteria) and protective factors (e.g. saliva flow) is tipped in favour of demineralization. The prevalence of caries suggests that the disease ...

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    14. Stanford University Receives a NIH Grant for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo

      Stanford University Receives a  NIH Grant for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo

      Stanford University Receives a 2015 NIH Grant for $448,758 for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion from one ...

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    15. Georgetown University Receives NIH Grant for Non-Invasive Evaluation of Transplant Kidney using OCT

      Georgetown University Receives NIH Grant  for Non-Invasive Evaluation of Transplant Kidney using OCT

      Georgetown University Receives a 2015 NIH Grant for $388,865 for Non-Invasive Evaluation of Transplant Kidney using OCT. The principal investigator is Peter Andrews. The program began in 2014 and ends in 2016. Below is a summary of the proposed work. There is currently a worldwide shortage of kidneys for transplantation due mainly to the fact that there is no reliable means to determine their viability (i.e., kidneys stored for long periods of time, etc.). Also, following transplantation, kidneys oftn do not function immediately and their status is unclear. Previously, we have shown that the histopathology of living, superficial ...

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    16. Duke University Receives NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health

      Duke University Receives NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health

      Duke University Receives a 2015 NIH Grant for Novel Determination of Microbicide PK in Women's Reproductive Health. The principal investigator is David Katz. The program began in 2012 and ends in 2016. Below is a summary of the proposed work. Vaginal microbicides offer much promise to prevent sexual transmission of HIV. The pharmacokinetics (PK) of a product (active pharmaceutical ingredient + dosage form) is central to prophylactic functionality (PD). But our ability to measure and predict microbicide PK is currently limited. Further, microbicide PD depends on how product + dosage regimen accommodate a range of conditions of the vaginal environment. These ...

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      Mentions: Duke University
    17. Massachusetts Institute of Technology Received a 2015 NIH Grant for Novel Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Received a 2015 NIH Grant for Novel Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Received a 2015 NIH Grant for Novel Diagnostics with Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1985 and ends in 2020. Below is a summary of the propose work. This proposal is a resubmission of a competing renewal application for an ongoing collaborative program among investigators at the Massachusetts Institute of Technology, New England Eye Center and University of Pittsburgh Medical Center Eye Center. This is a multidisciplinary program which integrates imaging technology research, clinical and small animal imaging studies. The specific aims are: Aim 1. Next generation OCT technology ...

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    18. UC Irvine Receives a 2015 NIH grant for Combined OCT/US/PAT System for Intravascular Imaging

      UC Irvine Receives a 2015 NIH grant for Combined OCT/US/PAT System for Intravascular Imaging

      University of California Irvine Receives a 2015 NIH grant for Combined OCT/US/PAT System for Intravascular Imaging. The principal investigator is Zhongping Chen. The program begain in 2015 and ends in 2019. Below is a summary of the propose work.

      Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, cholesterol, fibrous constituents, monocytes, and various other inflammatory cells in the arterial wall. Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. The major cause of deaths from heart attacks (86%) and brain aneurysm (45%) are due to "vulnerable plaques" that ...

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    19. VA North Texas Health Care System Receives NIH Grant for Prasugrel for Prevention of Early Saphenous Vein Grant Thrombosis.

      VA North Texas Health Care System Receives NIH Grant for Prasugrel for Prevention of Early Saphenous Vein Grant Thrombosis.

      VA North Texas Health Care System Receives a 2015 NIH Grant for Prasugrel for Prevention of Early Saphenous Vein Grant Thrombosis. The principal investigator is Emmanouil Brilakis. The program began in 2012 and ends in 2016. Below is a summary of the proposed work. Early aortocoronary saphenous vein bypass graft (SVG) failure is common and is associated with high morbidity and mortality. Aspirin significantly reduces the incidence of early saphenous vein graft failure, whereas clopidogrel use provided conflicting results in small randomized studies. Prasugrel is a novel thienopyridine that provides more rapid, consistent, and intense platelet inhibition than clopidogrel. However ...

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    20. Texas Engineering Experiment Station Receives NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research

      Texas Engineering Experiment Station Receives NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research

      Texas Engineering Experiment Station Receives a 2015 NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research. The Principal invesigator is Brian Applegate. The program began in 2012 and ends in 2017. Below is a summary of the proposed work.

      Atherosclerosis is the leading cause of morbidity and mortality in the United States and is characterized as a systemic, progressive disease process in which the arterial wall thickens through a process of inflammation, oxidative stress, and dyslipidemia. This process leads to plaque formation and flow limitation in the vessel lumen. The sudden rupture of this arterial plaques ...

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    21. Columbia University Receives NIH Grant for Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration

      Columbia University Receives NIH Grant for Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration

      Columbia University Receives a 2015 NIH Grant for $281,840 for Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration. The principal investigator is Ronald Silverman. The program began in 2012 and ends in 2016. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is a disease of the retinal pigment epithelium characterized by the appearance of protein/lipid deposits (drusen), geographic atrophy and neovascularization. Techniques currently used for diagnostic imaging of AMD include indocyanine green dye or fluorescein angiography, autofluorescence imaging and optical coherence tomography (OCT). OCT images depict optical backscatter, caused by variation in ...

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    22. “How Does Breast Cancer Develop?” Pilot Grants Awarded to Multidisciplinary Teams Using the Intraductal Approach to Advance Breast Cancer Prevention

      “How Does Breast Cancer Develop?” Pilot Grants Awarded to Multidisciplinary Teams Using the Intraductal Approach to Advance Breast Cancer Prevention

      Dr. Sheldon Feldman and Dr. Fatih Balci study intraductal approaches to breast cancer. They are currently investigating the effectiveness of optical coherence tomography (OCT), which is used in cardiology to look at blood vessels from the inside using light instead of sound (as an ultrasound does) to create three-dimensional images. OCT may be able to identify early changes in the breast duct before ductal carcinoma in situ (DCIS) or cancer forms. This consortium received $17,000 to study whether it is feasible to use OCT to distinguish different types of breast cells and tissues and whether OCT can show features ...

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    23. Wasatch Photonics Receives NIH SBIR for a Hand-Held Advanced Functional Imaging for Assessing Local Tissue Oxygenation

      Wasatch Photonics Receives NIH SBIR for a Hand-Held Advanced Functional Imaging for Assessing Local Tissue Oxygenation

      Wasatch Photonics Received a 2015 NIH SBIR for $149,950 for a Hand-Held Advanced Functional Imaging for Assessing Local Tissue Oxygenation. The principal investgator is Roman Kuranov. The program began in 2015 and ends in 2015. Below is a summary of the purposed work. We propose development of an advanced functional imager to assess red blood cell (RBC) transfusion. The prototype will be tested in a functional phantom during this SBIR Phase I project. The key features of the imager are the ability to quantify local tissue oxygenation with a handheld probe for easy tissue access. Our preliminarily market research ...

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    24. Florida International University Received a 2015 NIH Grant Multimodal Retinal Functional Imaging for Diabetic Retinopathy

      Florida International University Received a 2015 NIH Grant Multimodal Retinal Functional Imaging for Diabetic Retinopathy

      Florida International University Received a 2015 NIH Grant for $542,882 for Multimodal Retinal Functional Imaging for Diabetic Retinopathy. The principal investigator is Shuliang Jiao. The program begain in 2013 and ends in 2016. Below is a summary of the proposed work. Diabetic retinopathy (DR) is a leading cause of irreversible blindness among working-age adults, which is a typical type of ischemia driven retinal disease characterized by microvascular damage to the retina in patients with diabetes. DR progresses through a sequence of recognizable stages, which begin with structural and functional derangement of the retinal microcirculation even before the early clinical ...

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