1. Articles in category: Funding

    1-24 of 542 1 2 3 4 ... 21 22 23 »
    1. University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives a 2016 NIH Grant for $662,015 for Interferometric Optophysiology of the Human Retina. The principal investigator is Austin Roorda. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Our goal is to develop a new technology for non-invasive optical monitoring of activity of individual retinal neurons and their light-driven inputs at cellular resolution, in the living human retina. If successful, this technology will provide an entirely new and objective approach to understand and monitor treatment of retinal disease, thereby transforming scientific studies of the eye ...

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    2. OCT Medical Imaging Inc. Receives a NIH Grant for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System

      OCT Medical Imaging Inc. Receives a NIH Grant for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System

      OCT Medical Imaging Inc. Receives a 2016 NIH Grant for $1,252,899 for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System. The principal investigator is Tirunelveli Ramalingam. The program began in 2015 and ends in 2018. Below is a summary of the proposed work. Understanding that not a single imaging technique can alone address needs of all vascular diagnosis, OCT medical imaging Inc. (OCTMI) propose to develop a clinical multimodal intravascular imaging system encompassing ultra-high resolution optical coherence tomography (OCT) and IVUS. This Combined multimodal vascular imaging system will permit cross-sectional visualization of vascular artery with ...

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    3. Johns Hopkins University Receives a NIH Grant for Tissue Pharmacology Imaging and Modeling

      Johns Hopkins University Receives a NIH Grant for Tissue Pharmacology Imaging and Modeling

      Johns Hopkins University Receives a 2016 NIH Grant for $542,099 for Tissue Pharmacology Imaging and Modeling. The principal investigator is Namandjen Bumpus. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. A successful microbicide product has pharmacokinetics (PK) that effect prophylactic pharmacodynamics (PD). Product design should manipulate candidate compositions, volumes, and drug packaging in a rational manner to yield target PK/PD; but we have limited understanding of this relationship. Further, our methods for experimentally evaluating PK in animals and humans are limited: they do not delineate drug concentration distributions throughout ...

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    4. Drs. Campbell, Hariri, and Lehman Receive 2016 LUNGevity Career Development Awards

      Drs. Campbell, Hariri, and Lehman Receive 2016 LUNGevity Career Development Awards

      Lida Hariri , MD, Massachusetts General Hospital, who will use a novel high-resolution imaging technique called Optical Coherence Tomography to perform virtual optical biopsies to determine its value in complementing tissue biopsies in the determination of early-stage lung cancer

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    5. Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for $573,805 for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy. The principal investigator is Guillermo Tearney. The program began in $2014 and ends in 2019. Below is a summary of the proposed work. Celiac disease (CD) is an autoimmune response to gluten proteins that affects 3M people in the US and 50M worldwide. These proteins incite an inflammatory reaction that eventually destroys the absorptive villi in the duodenum, resulting in gastrointestinal symptoms, malabsorption, malnutrition, and an increased incidence of other autoimmune diseases, diabetes, and cancer. A definitive diagnosis of CD is ...

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    6. UCLA Receives a NIH Grant for Detection of Glaucoma Progression With Macular OCT Imaging

      UCLA Receives a NIH Grant for Detection of Glaucoma Progression With Macular OCT Imaging

      The University of California at Los Angeles Receives a 2016 NIH Grant for $229,139 for Detection of Glaucoma Progression With Macular OCT Imaging. The principal investigator is Kourous Nouri-Mahdavi. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. This application is a formal request for a career development award (K23) for an academic glaucoma specialist with a serious interest in the role of imaging in glaucoma using optical coherence tomography (OCT). This will allow the candidate to establish a clinical research program with the main goal of improving detection of glaucoma ...

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    7. Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives a 2016 NIH Grant for $483,717 for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects. The principal investigator is Michael Jenkins. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Congenital heart defects (CHDs) are one of the most common and devastating birth defects, afflicting 32,000 babies born in the United States each year, and over 1 million Americans alive today. Altered hemodynamics during development has been shown to be a contributing factor to CHDs, regardless of whether ...

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    8. Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $590,459 for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The human brain is made up of an array of functionally and structurally defined regions. Localizing these regions is critical for early diagnosis of an array of diseases such as Alzheimer's disease (AD), as well as for neuroscientific research aimed at understanding the brain's functional and structural properties and clinical intervention in drug-resistant depression ...

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    9. Baylor College of Medicine Receives NIH Grant for Small Animal Visual System Module

      Baylor College of Medicine Receives NIH Grant for Small Animal Visual System Module

      Baylor College of Medicine Receives a 2016 NIH Grant for $139,554 for Small Animal Visual System Module. The principal investigator is Ching-Kang Chen. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. Recent advance in genome editing technology will lead to an explosion of small animal models of human diseases. These animal models, when characterized efficiently and correctly, will benefit investigations that elucidate disease mechanisms and lead to exciting discovery of therapeutic interventions. The small animal visual system analysis module (SAVSAM) of the Baylor College of Medicine (BCM) Vision Core Facilities ...

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    10. Massachusetts General Hospital Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $1,460,266 for the Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the propose work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the ...

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    11. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography ...

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    12. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of ...

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    13. Horizon 2020 project aims to transform optical coherence tomography

      Horizon 2020 project aims to transform optical coherence tomography

      Advances in silicon photonics development for datacom applications are set to be applied in biophotonics, with a new €4.9 million European project aiming to create a tiny and low-cost system for optical coherence tomography (OCT). While OCT has become widely used for ophthalmic diagnosis and is gaining traction in cardiovascular imaging, the technique still relies on relatively expensive and bulky combinations of laser, optical and electronic equipment. Now a team led by Wolfgang Drexler from the Medical University of Vienna is aiming to shrink the core technology to no more than the size of a coin, primarily to diagnose ...

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    14. Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives a 2016 NIH Grant for $742,986 for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function. The principal investigator is David Sosnovik. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. Pressure overload of the left and right ventricles initially leads to adaptive hypertrophy. This, however, is frequently followed by maladaptive hypertrophy, heart failure and death. We hypothesize here that changes in 3D myocardial fiber architecture play a significant role in the deleterious transition from adaptive to maladaptive hypertrophy and heart failure. We further hypothesize that ...

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    15. State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received a 2016 NIH Grant for $195,071 for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents. The principal investigator is Congwu Du. The program began in 2016 and ends in 2018. Below is a summary of the propose work. The medial prefrontal cortex (mPFC) plays a critical role in cocaine addiction. The mechanism underlying mPFC dysfunction in cocaine abusers are not well understood and could reflect disruption of cerebral blood flow (cocaine’s vascular effects) and/or disruption of dopaminergic modulation of the prefrontal cortex (cocaine’s ...

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    16. Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives a 2016 NIH Grant for $416,250 for Quantitative Optical Imaging of Cilia-Driven Fluid Flow. The principal investigator is Michael Choma. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Respiratory diseases are major causes of pediatric morbidity and mortality. These diseases are incompletely understood, which is a barrier to improving clinical care. Therefore, new mechanisms of disease need to be discovered. Optical imaging (e.g. optical coherence tomography [OCT]) will enable these discoveries since traditional imaging (e.g. x-ray, CT, MRI) cannot visualize structures smaller than ~1 mm ...

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    17. Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives a 2016 NIH Grant for $746,856 for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo. The principal investigator is Robert Brown. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. This Biomedical Research Partnership (BRP) proposal involves a partnership among a biomedical engineering team, a pulmonary physiology team, and a clinical pulmonary medicine team. This research program will incorporate state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human obstructive lung diseases (OLD). Optical coherence tomography (OCT) is ...

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    18. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives  NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      University of Illionois at Urbana-Champaign Receives a 2016 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investiagator is Stephen Boppart. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...

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    19. EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential

      EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential

      Cancer diagnosis relies on the long and complex histology process. During surgery, there is currently no real- time guidance at the histology level, leading to up to 40% of reoperations . Along the cancer care workflow , in particular for tumor biopsy and excision, current existing preoperative and intraoperative imaging techniques fail to perform a reliable in situ diagnosis. Moreover, the complete pathological diagnosis, often based on histology slides preparation, is usually only available after a few days. For these reasons a significant number of patients need to undergo secondary biopsy or surgery. The CAReIOCA project combined the latest advances in CMOS ...

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    20. An implant to catch metastatic cancer cells before they grow into tumors

      An implant to catch metastatic cancer cells before they grow into tumors

      There could be a way around this, though: a special imaging method under development at Northwestern University called Inverse Spectroscopic Optical Coherence Tomography (ISOCT). ISOCT detects molecular-level differences in the way cells in the body scatter light. And when we scan our implant with ISOCT, the light scatter pattern looks different when it's full of normal cells than when cancer cells are present. In fact, the difference is apparent when even as few as 15 out of the hundreds of thousands of cells in the implant are cancer cells. There's a catch – ISOCT cannot penetrate deep into tissue ...

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    21. Oregon Health and Science University Receives NIH Grant for Ossicle Vibration Measurement sin Conductive Hearing Loss

      Oregon Health and Science University Receives NIH Grant for Ossicle Vibration Measurement sin Conductive Hearing Loss

      Oregon Health and Science University Receives a 2016 NIH Grant for $418,717 for Ossicle Vibration Measurement sin Conductive Hearing Loss. The principal investigator is Steven Jaques. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane. The system is based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to ¿m amplitude. In Aim ...

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    22. University of Iowa Receives NIH Grant for 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema

      University of Iowa Receives NIH Grant for 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema

      University of Iowa Receives a 2016 NIH Grant for $339,750 for 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema. The principal investigator is Mona Garvin. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Currently, the clinical assessment of optic nerve swelling is limited by the subjective ophthalmoscopic evaluation by experts in order to diagnose and differentiate the cause of the optic disc edema. The long-term goal of our research effort is to develop automated 3D image-analysis approaches for the identification of an optimal set of ...

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    23. Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2016 NIH Grant for $288,576 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

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    1-24 of 542 1 2 3 4 ... 21 22 23 »
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