1. Articles in category: Funding

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    1. Duke University Receives NIH Grant for Handheld Confocal Scanning Laser Ophthalmoscope for Remote Screening of Diabetic Retinopathy

      Duke University Receives NIH Grant for Handheld Confocal Scanning Laser Ophthalmoscope for Remote Screening of Diabetic Retinopathy

      Duke University Receives a 2019 NIH Grant for $233,465 for Handheld Confocal Scanning Laser Ophthalmoscope for Remote Screening of Diabetic Retinopathy. The principal investigator is Joseph Izatt. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. This is an application for an Exploratory/Developmental Research Grant which brings together a team of engineers and clinician-scientists with expertise in ophthalmic imaging technology development and translation to advance the state of the art remote screening for diabetic retinopathy (DR). Diabetic retinopathy (DR) is a complication from diabetes mellitus (DM) that causes damage to ...

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    2. Case Western Reserve University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western Reserve University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western Reserve University Receives a 2019 NIH Grant for $732,934 for Computer Assisted Coronary Artery Stent Interventions. The principal investigator is David WIlson. The program began in 2018 and ends in 2022. Below is a summary of the proposed work. Computer assisted coronary artery stent interventions Summary When treating highly calcified coronary artery lesions with stents, interventional cardiologists, with limited information, make stressful treatment decisions, which can lead to inadequate stent deployment and poor outcomes, or even rare calamitous events. When calcification is present, a cardiologist must choose to use a normal sized angioplasty balloon; a larger angioplasty ...

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    3. Massachusetts General Hospital Receives NIH Grant for Novel Optical Coherence Tomography Tool Development for Quantitative Peripheral Nerve Imaging

      Massachusetts General Hospital Receives NIH Grant for Novel Optical Coherence Tomography Tool Development for Quantitative Peripheral Nerve Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $388,832 for Novel Optical Coherence Tomography Tool Development for Quantitative Peripheral Nerve Imaging. The principal investigator is Benjamin Vakoc. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Peripheral nerves serve as a bidirectional link between the central nervous system (CNS) and its distal targets. The autonomic nervous system (ANS), which is part of the peripheral nervous system, innervates internal organs to modulate their function and transmits sensory information back to the CNS. By selectively stimulating the ANS nerves, neuromodulation of target ...

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    4. Massachusetts General Hospital Receives NIH Grant for Blood Flow-Based Guidance and Diagnostics Using OCT

      Massachusetts General Hospital Receives NIH Grant for Blood Flow-Based Guidance and Diagnostics Using OCT

      Massachusetts General Hospital Receives a 2019 NIH Grant for $164,400 for Blood Flow-Based Guidance and Diagnostics Using OCT. The principal investigator is Nestor Uribe-Patarroyo. The program began in 2017 and ends in 2021. Below is a summary of the proposed work. Diseases diagnosed with assessment of blood flow account for 29% of deaths in the US and are leading causes of premature morbidity, including visual disorders which carry an economic burden of $35 bil- lion per year. The heart disease with the most impact on public health is coronary artery disease (CAD); more than one million percutaneous coronary interventions ...

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    5. Duke University Receives NIH Grant for Portable Stabilized Optical Coherence Tomography for Eye Care in Acute Care Settings

      Duke University Receives NIH Grant for Portable Stabilized Optical Coherence Tomography for Eye Care in Acute Care Settings

      Duke University Receives a 2019 NIH Grant for $384,440 for Portable Stabilized Optical Coherence Tomography for Eye Care in Acute Care Settings. The principal investigator is Anthony Kuo The program began in 2018 and ends in 2021. Below is a summary of the proposed work. This research proposal from a multi-disciplinary team including an emergency medicine physician, ophthalmologists, and biomedical engineers seeks to improve the ability of acute care providers to diagnose and triage eye pathology at the point of care. Acute care settings such as emergency departments frequently take care of patients seeking eye care. In these acute ...

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    6. University of Wisconsin-Madison Receives NIH Grant for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin-Madison Receives  NIH Grant for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics

      University of Wisconsin-Madison Receives a 2019 NIH Grant for $400,600 for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics. The principal investigator is Jack Jiang. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Voice disorders affect millions of people worldwide. Patients have reported many negative social econmic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and ...

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    7. Johns Hopkins University Receives NIH Grant for Eye Determinants of Cognition (EYEDOC) study.

      Johns Hopkins University Receives NIH Grant for Eye Determinants of Cognition (EYEDOC) study.

      Johns Hopkins University Receives a 2019 NIH Grant for $395,304 for Eye Determinants of Cognition (EYEDOC) study. The principal investigator is Alison Abraham. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Eye Determinants of Cognition (EyeDOC) Study Rationale: Dementia and mild cognitive impairment (MCI) pose enormous health and societal costs in our aging US population. While cerebral neural loss is known to contribute to Alzheimer's dementia, vascular diseases may contribute substantially to the total burden of dementia and its precursor, MCI. Small-vessel cerebrovascular changes, which are most strongly associated ...

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    8. Berkley Receives a 2019 NIH Grant for Interferometric Optophysiology of the Human Retina

      Berkley Receives a 2019 NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkley Receives a 2019 NIH Grant for $608,727 for Interferometric Optophysiology of the Human Retina. The principal investigator is Austin Roorda. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Our goal is to develop a new technology for non-invasive optical monitoring of activity of individual retinal neurons and their light-driven inputs at cellular resolution, in the living human retina. If successful, this technology will provide an entirely new and objective approach to understand and monitor treatment of retinal disease, thereby transforming scientific studies of the eye ...

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    9. Iowa City Medical Center Receives NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging.

      Iowa City Medical Center Receives NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging.

      Iowa City Medical Center Receives a 2019 NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury, and from idiopathic causes. Currently, the diagnosis of papilledema and its severity are assessed by direct funduscopic observation or digital fundus photographs using a six-stage grading scale. The scale is ...

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    10. Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives a 2019 NIH Grant for $ 505,632 for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance. The principal investigator is Jesung Park. The program began in 2016 and ends in 2021. Below is a summary of the proposed work.

      Sensorineural hearing loss (SNHL) is a source of significant morbidity and in isolated cases is irreversible. Most cases of SNHL are associated with damage or loss of cochlear hair cells. The diagnosis of SNHL is based primarily on audiometric testing as the inner ear cannot be “biopsied” without causing profound hearing loss. Contemporary ...

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    11. University of Washington Receives NIH Grant for In Vivo Photoreceptor Physiology in the Human Retina

      University of Washington Receives NIH Grant for In Vivo Photoreceptor Physiology in the Human Retina

      University of Washington Receives a 2019 NIH Grant for $100,000 for In Vivo Photoreceptor Physiology in the Human Retina.  The principal investigator is Ramkumar Sabesan. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. Photoreceptor death due to retinal degenerations is the leading cause of blindness in the developed world. Recent approaches to treat these blinding diseases include re-conferring the light sensitivity of the degenerated retina, either by genetic manipulation or stem-cell transplants of photoreceptors. The fundamental impediment to translating these treatments to the living human retina is the ability to ...

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    12. University of Alabama at Birmingham Receives NIH Grant for Functionally Validated Structural endpoints for Early AMD

      University of Alabama at Birmingham Receives NIH Grant for Functionally Validated Structural endpoints for Early AMD

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $511,340 for Functionally Validated Structural endpoints for Early AMD. The principal investigator is Cynthia Owsley. The program began in 2019 and ends in 2024. Below is a summary of the proposed work. Age-related macular degeneration (AMD), the leading cause of irreversible vision impairment in the US and third globally, is a disease of the photoreceptor support system involving the retinal pigment epithelium (RPE), Bruch's membrane, and the choriocapillaris, ultimately leading to photoreceptor demise and eventual vision loss. Our research with that of others has clearly documented the ...

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    13. University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives a 2019 NIH Grant for $215,469 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex ...

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    14. Stanford University Receives NIH Grant for Structural and Functional Tests of Ganglion cell Damage in Glaucoma

      Stanford University Receives NIH Grant for Structural and Functional Tests of Ganglion cell Damage in Glaucoma

      Stanford University Receives a 2019 NIH Grant for $360,264 for Structural and Functional Tests of Ganglion cell Damage in Glaucoma. The principal investigator is Anthony Morcia. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. This project will use a combination of structural and functional measurements to test the hypothesis that early- stage damage in human glaucoma occurs first in the inner plexiform layer (IPL) of the retina – especially its OFF sub-lamina – as suggested by murine glaucoma models. In the first Aim, we will use a novel visible-light optical coherence tomograph ...

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    15. OHSU Receives NIH Grant ffor Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

      OHSU Receives NIH Grant ffor Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

      Oregon Health and Science University Receives a 2019 NIH Grant for $250,000 for Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas. The principal investigator is Yan Li. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. To see well, the cornea must maintain near perfect clarity and shape. Several disease processes can distort corneal shape and degrade vision. These include ectasia/keratoconus (stromal thinning and bulging), primary epithelial deformation (contact lens-related warpage, dry eye, epithelial basement membrane dystrophy), and stromal changes (scar, stromal dystrophy, surgery). Some of these conditions ...

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    16. University Houston ReceivesNIH Grant for Optical Coherence Elastography of the Cornea

      University Houston ReceivesNIH Grant for Optical Coherence Elastography of the Cornea

      University Houston Receives a 2019 NIH Grant for $379,941 for Optical Coherence Elastography of the Cornea. The principal investigator is Kirill Larin. The program began in 2012 and ends in 2020. Below is a summary of the proposed work. The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement ...

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    17. OHSU Receives NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy

      OHSU Receives NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy

      Oregon Health and Science University Receives a 2019 NIH Grant for $281,474 for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy. The principal investigator is Yali Jia. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. Our group has demonstrated that optical coherence tomography angiography (OCTA) can address many of the disadvantages of fluorescein angiography (FA) in diabetic retinopathy (DR). OCTA uses the intrinsic contrast of blood cell motion and therefore does not require dye injection, making it entirely non-invasive and suitable for routine examination. OCTA is three-dimensional and can ...

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    18. Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation

      Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation

      Duke University Receives a 2019 NIH Grant for $150,000 for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation. The principal investigator is Joseph Izatt. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. This is an application for an Exploratory/Developmental Research Grant which brings together a team of experts in ophthalmic imaging, surgery and robotics to advance the state of the art in image-guided robotic microsurgical intervention. Corneal transplants are one of the most commonly performed allograft procedures worldwide, although there remains a substantial risk of immune ...

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    19. UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Auytoflourescence Fundus Camera For Age-Related Macular Degeneration

      UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Auytoflourescence Fundus Camera For Age-Related Macular Degeneration

      University of Illinois at Urbana Champaign Receives a 2019 NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Auytoflourescence Fundus Camera For Age-Related Macular Degeneration. The principal investigator is Liang Giao. Below is a summary of the proposed work. An imaging modality that allows for fast, simultaneous, noninvasive probing of both 3D cellular resolution retinal morphology by optical coherence tomography (OCT) and molecular-specific functions by autofluorescence (AF) could substantially improve both basic understanding and the early diagnosis of age- related macular degeneration (AMD), the leading cause of blindness in the developed world. The evaluation and management of AMD utilize several ...

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    20. Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition

      Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition

      Boston Medical Center Receives a 2019 NIH Grant for $197,189 for Eye To Brain: Eye Biomarkers and Cognition. The principal investigator is Manju Subramanian. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. The goal of our research is to identify ocular biomarkers that have diagnostic and potentially prognostic utility in Alzheimer's Disease (AD), and establish a relationship to cognition. We seek to determine this relationship in an already established cohort of patients (the Vitreous Biomarkers Study, or VBS) with eye disease where protein biomarkers have been identified in the ...

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    21. Physical Sciences Receives NIH Grant for Optical Prove for Real-Time Assessment of Periodontal Health Status

      Physical Sciences Receives NIH Grant for Optical Prove for Real-Time Assessment of Periodontal Health Status

      Physical Sciences Incorporated Received a 2019 NIH Grant for $641,715 for Optical Prove for Real-Time Assessment of Periodontal Health Status. The principal investigator is Nicusor Iftimia. The program began in 2013 and ends in 2020. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA is proposing to develop a technology that will address a major unmet medical need in periodontology: the lack of tools to quantitatively and objectively assess the health/disease status of the gingival soft tissues. The proposed technology will combine high resolution micro-Optical Coherence Tomography ...

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    22. University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives a 2019 NIH Grant for $381,250 for Choroidal Disease Mechanisms in AMD. The principal investigator is Elliott Sohn. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. We propose to investigate the pathophysiology of choroidal degeneration in age-related macular degeneration (AMD), the most common form of untreatable central vision loss in the western world. The choroid, the complex vascular system supplying the outer retina, photoreceptors, and retinal pigment epithelium (RPE), can now be visualized in living humans using enhanced depth imaging optical coherence tomography (OCT). Recent studies ...

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    23. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives NIH Grant  for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives a 2019 NIH Grant for $39,955 for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography. The principal investigator is Brian Soetikno. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The retina is one of the most metabolically active tissues in the human body, making it particularly susceptible to hypoxia. In diabetic retinopathy (DR), aberrant oxygen metabolism has been hypothesized to play a pivotal role its pathogenesis. An improved understanding of how imbalances in oxygen delivery and demand lead to the progression of DR ...

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    24. University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives a 2019 NIH Grant for $487,053 for Understanding Otoacoustic Emissions. The principal investigator is Christopher Shera. The program began in 1999 and ends in 2024. Below is a summary of the proposed work. Realizing the potential of otoacoustic emissions (OAEs) as noninvasive probes of cochlear function requires understanding the physical and physiological mechanisms that generate and shape these sounds. To address important unresolved issues of cochlear mechanics while improving our understanding of OAE generation, we propose three aims involving innovative theoretical modeling rigorously tested by experimental measurements. The first Aim studies the action of ...

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