1. Articles in category: Funding

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    1. Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System

      Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System

      Notal Vision, Ltd., ("Notal") a privately-held ophthalmic diagnostic services company, focused on advancing eye care by extending ophthalmic disease management from the clinic to the home, has announced the U.S. Food and Drug Administration (FDA) granted the Notal Vision Home-based Optical Coherence Tomography (OCT) System with "Breakthrough Device" designation for the agreed upon indications for use. This designation indicates that FDA intends to provide interactive and timely communication with the sponsor during device development and throughout the review process for various types of premarket submissions. FDA's Breakthrough Devices Program was established in late 2016 to help patients gain ...

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      Mentions: FDA Notal Vision
    2. Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

      This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. Ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.

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    3. PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare, a medical device company headquartered in Champaign, Illinois, received a $2.1 million award through the National Institute of Health (NIH) Phase llb Small Business Innovation Research (SBIR) program. The National Institute of Deafness & Communications Disorders (NIDCD), part of the NIH, is funding this award. The NIDCD conducts and supports research in the normal and disordered processes of hearing, balance, taste, smell, voice, speech, and language. In fiscal years 2015 and 2016 PhotoniCare was awarded SBIR Phase ll funding from the NIDCD. The SBIR program is the mechanism by which the NIH and other Federal agencies bring innovative solutions ...

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    4. OCTLIGHT Closes Investment Round on Path to Commercialize OCT Swept Source

      OCTLIGHT Closes Investment Round on Path to Commercialize OCT Swept Source

      OCTLIGHT secures funding years ahead upon successful reaching key milestone OCTLIGHT ApS announces that it has closed an investment round following the successful completion of milestones towards commercializing OCT swept source modules. The funding, which was closed according to plan, will cover the activities of OCTLIGHT over the coming years, focused on development of OCT swept source modules for Ophthalmology as the primary market. Wavelength tuning range doubled to 52 nm showing path towards goal of 100 nm OCTLIGHT has achieved significant milestones towards bringing OCT swept source modules to market. The development of the core VCSEL technology continues, with ...

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    5. University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives a 2017 NIH Grant for $78,500 for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue. The principal investigator is Benjamin Sherlock. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. Cardiovascular disease is a leading cause of death globally. In vitro engineering of replacement blood vessels has emerged as a promising area of research that has the potential to provide lifesaving therapy in patients where autologous bypass grafts are not possible. The challenges of vascular tissue engineering require the developing samples ...

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    6. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives a 2017 NIH Grant for $225,116 for Method for Accurate Retinal Oxygen Metabolic Rate Extraction. The principal investigator is Wenzhong Liu. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. DR is a secondary complication of diabetes and a leading cause of blindness in the world. Although it is well known that DR is driven by ischemia, the current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non-proliferative DR and angiogenesis in proliferative DR. As a result, when ...

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    7. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant  for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives a 2017 NIH Grant for $559,269 for Functional and Structural Optical Coherence Tomography for Glaucoma. The principal investigator is David Huang. The program began in 2013 and ends in 2021. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnosis and close monitoring of glaucoma are important because the onset is insidious and the damage is irreversible. Advanced imaging modalities such as optical coherence tomography (OCT) have been used in the past 2 decades to improve the objective evaluation of glaucoma. OCT has higher axial spatial resolution ...

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    8. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of treating these devastating diseases is a formidable task. Nevertheless, trials examining novel therapeutic strategies are underway. An important key to success in the early phases of such trials is selection ...

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    9. Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives a 2017 NIH Grant for $25,000 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system for use in point of care settings. The target system price will be one third the price of currently available research OCT system while providing system performance comparable to other entry level OCT imaging systems. By breaking ...

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    10. Massachusetts General Hospital Receives NIH Grant The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2017 NIH Grant for $171,000 The Center for Biomedical OCT Research and Translation. The principal investogator is Brett Bouma. THe progbram began in 2017 and ends in 2018. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource will ...

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    11. Iowa City VA Receives NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging

      Iowa City VA  Receives NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging

      Iowa City VA Medical Center Receives a 2017 NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury, and from idiopathic causes. Currently, the diagnosis of papilledema and its severity are assessed by direct funduscopic observation or digital fundus photographs using a six-stage grading scale. The scale ...

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    12. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography (OCT ...

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    13. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2017 NIH Grant for $37,696 Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for activation ...

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    14. Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives a 2017 NIH Grant for $139,730 for Imaging Structure and Function. The principal investigator is Thomas Clandinin. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Imaging technologies such as confocal microscopy, multiphoton microscopy and super- resolution imaging as well as optical coherence tomography have transformed the ability of scientists to observe structural and functional changes in the visual system, in vivo and ex vivo, in both health and disease. The overarching goal of the imaging core is to transform the ability of vision scientists to use these ...

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    15. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives a 2017 NIH Grant $317,544 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion from ...

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    16. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography (OCT ...

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    17. University of Miami Receives NIH Grant f for Dynamics of the Aging Ciliary Muscle

      University of Miami Receives NIH Grant f for Dynamics of the Aging Ciliary Muscle

      The long-term goal of this project is to enable the development of more effective treatments for presbyopia, the loss of near vision with age, by providing new insight into the mechanism behind presbyopia. The prevailing theory suggests that presbyopia is due mainly to age-related changes in the stiffness of the lens, but alternative theories have been proposed suggesting that age-related changes in the ciliary muscle may play a significant role. Age-related changes in the function of the ciliary muscle have been difficult to characterize in vivo due to the lack of suitable clinical imaging technology. The project will address two ...

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    18. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant  for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2017 NIH Grant for $1,191,714 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease. The principal investigator is Danny Wang. The program began in 2016 and ends in 2018. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are ...

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    19. Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives a 2017 NIH Grant for $50,000 Quantitative Imaging of Collagen Morphology in Human Scars. The principal investigator is Martin Villiger. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The overall goal of the proposed research is to develop and validate high-resolution birefringence imaging. The intrinsic birefringence of collagen offers an attractive contrast mechanism to investigate the collagen morphology in human skin and scars. Non-invasive characterization of the collagen organization in scar tissue would facilitate clinical trials that investigate novel therapeutic approaches to reduce scarring by providing ...

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    20. Physical Sciences, Incorporated Receives NIH Grant for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Physical Sciences, Incorporated Receives NIH Grant  for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Physical Sciences, Incorporated Receives a 2017 NIH Grant for $525,207 for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins. The principal investigator is Nicusor Iftima. The program began in 2014 and end sin 2019. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) and Caliber ID, Rochester, NY proposes to develop a novel technology for real-time assessment of surgical margins on breast cancer lumpectomy specimens and provide immediate feedback to the surgeon. A multimodal microscope will be used in conjunction with a high sensitivity cancer targeting agent ...

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    21. Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex

      Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex

      Massachusetts General Hospital Receives a 2017 NIH Grant for $474,273 for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex. The principal investigator is Anastasia Yendiki. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The objective of the proposed research is to map the organization of human white matter (WM) with cutting-edge ex vivo imaging technologies. This work will produce microscopic-level information on several long-range WM projections, as well as a more targeted mapping of circuits that serve the prefrontal cortex (PFC). These circuits are of particular interest in ...

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    22. LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients

      LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients

      LX Medical Corporation Receives a 2017 NIH Grant for $223,403 for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients. The principal investigator is Andrei Vertikov. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Lung transplantation is increasingly used to treat patients with end-stage lung diseases. Complications frequently occur with chronic allograft rejection causing most of late morbidity and mortality in lung transplant recipients. Pathological manifestations of chronic rejection mostly affect small airways or bronchioles in the lung, often progressing undetected until the patient presents with an ...

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    23. New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives a 2017 NIH Grant for $654,143 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2016 and ends in 2019. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of upmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project ...

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    24. University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core

      University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core

      University of Alabama at Birmingham Receives a 2017 NIH Grant for $43,191 for Occular Phenotyping Core. The principal investigator is Timothy Kraft. A summary of the proposed work is given below. Non-invasive assessment of eye structure and function is essential to both basic and translational research in vision science. Widely used technologies include slit lamp for biomicroscopy of anterior and posterior segment, electroretinography (ERG, for massed retinal signal separable into components), optical coherence tomography (OCT) for display of layered tissues in posterior and anterior segments, imaging of the fundus via multiple modes of visualization (color, autofluorescence, dye-based angiography, infrared ...

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