1. Articles in category: Funding

    1-24 of 373 1 2 3 4 ... 14 15 16 »
    1. Massachusetts General Hospital Receives NIH Grant for The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives 2014 NIH Grant For $1,449,151 for The Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly ...

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    2. Dynamics of a short cavity swept source OCT laser

      Dynamics of a short cavity swept source OCT laser

      We investigate the behaviour of a short cavity swept source laser with an intra cavity swept filter both experimentally and theoretically. We characterise the behaviour of the device with real-time intensity measurements using a fast digital oscilloscope, showing several distinct regimes, most notably regions of mode-hopping, frequency sliding mode-locking and chaos. A delay differential equation model is proposed that shows close agreement with the experimental results. The model is also used to determine important quantities such as the minimum and maximum sweep speeds for the mode-locking regime. It is also shown that by varying the filter width the maximum sweep ...

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    3. University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for $188,364 for Computational Ophthalmology. The principal investigator is Linda Zangwill. The program began in 2014 and ends in 2014. Below is a summary of the proposed work. COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization ...

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    4. University of California at San Diego receives NIH Grant for Studying Animal Structure and Function

      University of California at San Diego receives NIH Grant for Studying Animal Structure and Function

      University of California at San Diego received a 2014 NIH Grant for $167,628 for Animal Structure and Function. The principal investigator is Dirk-Uwe Bartsch. The program began in 2014 and ends in 2015. Below is a summary of the proposed work. The Animal Structure and Function Module will provide new centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The recent growth in the number of faculty in the Department of Ophthalmology conducting animal structure ...

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    5. Physical Sciences Receives NIH Grant for Optical Coherence Tomography Based on Freeze Drying Microscopy

      Physical Sciences Receives NIH Grant for Optical Coherence Tomography Based on Freeze Drying Microscopy

      Physical Sciences Incorporated Received a 2014 NIH Grant for $538,335 for Optical Coherence Tomography Based on Freeze Drying Microscopy. The principal investigator is Mircea Mujat. The program began in 2009 and ends in 2015. Below is a summary of the proposed work. Physical Sciences Inc. (PSI), in collaboration with the University of Connecticut (UConn), proposes to develop the 2nd generation of an advanced 3D freeze-drying microscopy (FDM) system to advance the understanding of freeze-drying and to enable the development of efficient commercial freeze drying processes. During the Phase I program PSI demonstrated the application of Optical Coherence Tomography (OCT ...

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    6. Baylor College of Medicine Receives NIH Grant for Studying Biomechanics of Early Mammalian Cardiogenesis

      Baylor College of Medicine Receives NIH Grant for Studying Biomechanics of Early Mammalian Cardiogenesis

      Baylor College of Medicine Received a 2014 NIH Grant for $378,647 for Biomechanics of Early Mammalian Cardiogenesis. The principal investigator is Irina Larina. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Congenital heart defects are among the most common birth defects and the leading cause of death in children born with congenital defects. Understanding how the early embryonic heart functions and what regulatory mechanisms are involved in early cardiogenesis is highly important for advancement of heart defects research. Biomechanical stimuli, including blood flow and heart contraction, are important regulators of ...

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    7. University of Houston Receives NIH Grant for Optical Coherence Elastography of the Cornea

      University of Houston Receives NIH Grant  for Optical Coherence Elastography of the Cornea

      University of Houston Received a 2014 NIH Grant for $388,129 for Optical Coherence Elastography of the Cornea. The principal investigator is Kirill Larin. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement ...

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    8. MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Received a 2014 NIH Grant for $302,576 for Optical Biopsy Using Optical Coherence Tomography. THe principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

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    9. Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography

      Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography

      Yale University Receivesd a 2014 NIH Grant for $201,881 for Development of a New Light Sources for Parallel Optical Coherence Tomography. The principal investigator is Michel Choma. The program began in 2013 and ends in 2015. Below is a summary of the proposed work. The ability of optical coherence tomography (OCT) to perform high-speed, micron-scale, cross-sectional imaging has transformed ophthalmic medicine and has the potential to transform cardiovascular, gastrointestinal, pulmonary, and dermatological medicine. Current OCT systems use raster scanning, a serial method for acquiring depth reflectivity profiles at different locations on a sample. Shifting the paradigm fro serial to ...

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    10. UIUC Receives NIH Grant for Partnership for Primary Care Imaging

      UIUC Receives NIH Grant for Partnership for Primary Care Imaging

      University of Illinois at Urbana Champaign Received a 2014 NIH Grant for $933,337 for Partnership for Primary Care Imaging. The principal investigator is Stephen Boppart. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Primary Care Medicine, including Family Practice and Pediatrics, has traditionally relied on physical exam skills and simplistic instruments for critical diagnostic decision making, monitoring, and referral to medical specialists. The otoscope and ophthalmoscope are two historical and ubiquitous instruments that largely only illuminate and magnify tissue surfaces in the ear and eye, respectively. This Partnership will develop ...

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    11. UC Riverside Receives a 2014 NIH Grant for Studying Optical Detection of the Pre-Seizure State

      UC Riverside Receives a 2014 NIH Grant for Studying Optical Detection of the Pre-Seizure State

      UC Riverside Received a 2014 NIH Grant for $437,523 for Studying Optical Detection of the Pre-Seizure State. The principal investigator is Devin Binder. The program began in 2-012 and ends in 2016. Below is a summary of the proposed work. Reliable means of detecting changes which occur during the "pre-seizure state" could serve as a method of seizure prediction, a benchmark in epilepsy research (NIH Curing Epilepsy Conferences, 2000 and 2007). Our preliminary data indicate pre-seizure constriction in brain extracellular space (ECS) accompanied by reduction in near-infrared (NIR) optical scattering prior to detection of seizure by electroencephalography (EEG). The ...

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    12. Visdex Corporation Received a 2014 NIH Grant for Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease

      Visdex Corporation Received a 2014 NIH Grant for Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease

      Visdex Corporation Received a 2014 NIH Grant for $496,465 for Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease. The principal investigator is Scott Frasier. The program began in 2010 and ends in 2015. Below is a summary of the proposed work. Since its introduction in the 1960's, fluorescein angiography (FA) has been the gold standard for retinal vascular diagnosis. However, FA is costly, invasive, and time-consuming, which limits its usefulness as a screening tool. As a potential non-invasive alternative to FA for diagnosing retinovascular disease, we have developed an imaging method called phase contrast optical coherence tomography ...

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    13. UC Irvine Receives at 2014 NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      UC Irvine Receives at 2014 NIH Grant  for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      University of California Irvine Receives at 2014 NIH Grant for $122,254 for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT. The principal investigator is Jun Zhang. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States. Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for ...

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    14. Motion artifact and background noise suppression on optical microangiography frames using a naïve Bayes mask

      Motion artifact and background noise suppression on optical microangiography frames using a naïve Bayes mask

      Optical coherence tomography (OCT) is a technique that allows for the three-dimensional (3D) imaging of small volumes of tissue (a few millimeters) with high resolution ( ∼ 10     μ m ). Optical microangiography (OMAG) is a method of processing OCT data, which allows for the extraction of the tissue vasculature with capillary resolution from the OCT images. Cross-sectional B-frame OMAG images present the location of the patent blood vessels; however, the signal-to-noise-ratio of these images can be affected by several factors such as the quality of the OCT system and the tissue motion artifact. This background noise can appear in the en face projection ...

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    15. Optical Coherence Tomography Used to Image Pain Management in Labor and Diabetic Retinopathy and Glaucoma

      Optical Coherence Tomography Used to Image Pain Management in Labor and Diabetic Retinopathy and Glaucoma

      Researchers are using established imaging technology called optical coherence tomography (OCT) and integrating it with other devices for cutting-edge imaging of women in labor and individuals with diabetic retinopathy and glaucoma. The research was presented at CLEO 2014, the Conference on Lasers and Electro-Optics, which was held June 8–13, 2014, in San Jose (CA, USA). OCT uses scattered “echoes” or reflections of light waves to create high-resolution images of biologic tissues, similar to ultrasound imaging but with one order of magnitude improvement in the resolution. Ophthalmologists have long been using OCT to study the retina. More recently, OCT has ...

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    16. Fiber-optic polarization diversity detection for rotary probe optical coherence tomography

      Fiber-optic polarization diversity detection for rotary probe optical coherence tomography

      We report a polarization diversity detection scheme for optical coherence tomography with a new, custom, miniaturized fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the X and Y OCT polarization channels prior to interference and the PM fiber outputs ensure defined X and Y axes after interference. Advantages for this scheme include easier alignment, lower cost, and easier miniaturization compared to designs with free-space bulk optical components. We demonstrate the utility of the detection system to mitigate the effects of rapidly changing polarization states ...

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    17. Massachusetts General Hospital Receives NIH Grant for Improved Screening and Surveillance in Barrett's Patients

      Massachusetts General Hospital Receives NIH Grant for Improved Screening and Surveillance in Barrett's Patients

      Massachusetts General Hospital received a 2014 NIH grant for $464,015 for Improved Screening and Surveillance in Barrett's Patients. The principal investigator is Gary Tearney. The program began in 2003 and ends in 2015. Below is a summary of the proposed work. Barrett's esophagus (BE) is a metaplastic condition that is associated with chronic gastroesophageal reflux disease (GERD). BE is important because it can progress to esophageal adenocarcinoma, a cancer with a high mortality rate and a rapidly rising incidence. Since identification of BE with dysplasia or early cancer can lead to cure, gastroenterological societies recommend that patients ...

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    18. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University receives a 2014 NIH grant for $373,641 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the prposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of ...

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    19. University of Wisconsin Receives NIH grant for Spectral Domain Optical Coherence Tomography Instrument for Multimodal Imaging

      University of Wisconsin Receives NIH grant  for Spectral Domain Optical Coherence Tomography Instrument for Multimodal Imaging

      University of Wisconsin receives a 2014 NIH grant for $210,000 for Spectral Domain Optical Coherence Tomography Instrument for Multimodal Imaging. The principal investigator is Gillian McLellan. The program began in 2014 and ends in 2015. Below is a summary of the proposed work. This proposal requests funds for a spectral domain optical coherence tomography (OCT) from Heidelberg Industries, Inc. This instrument will be housed in a laboratory located at the University of Wisconsin McPherson Eye Research Institute (ERI), within the Wisconsin Institutes for Medical Research (WIMR) and immediately adjacent to the Clinical Science Centre at University of Wisconsin-Madison. This ...

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    20. University of Illinois Urbana-Champaign receives NIH Grant for Interoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins

      University of Illinois Urbana-Champaign receives NIH Grant for Interoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins

      University of Illinois Urbana-Champaign received at 2014 NIH grant for $483,605 for Interoperative Label-Free Optidcal Molecular Imaging of Breast Tumor Margins. The principal investigator is Stephen Boppart. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to verify ...

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    21. OCT in Zero Gravity

      OCT in Zero Gravity

      Heidelberg Engineering’s annual 2014 Xtreme Research Award was presented to the NASA Ocular Health Study during the recent award ceremony in Orlando, Florida. Over 200 scientists who were in the city for the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) gathered for the event. Dr. Nimesh Patel, Assistant Professor at the University of Houston, College of Optometry and a consultant to NASA accepted the award and presented the award lecture. In the presentation, entitled “OCT in Zero G,” Dr. Patel provided details about the use of SPECTRALIS ® Optical Coherence Tomography (OCT) on board the ...

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    22. OCT Developments Address Skin

      OCT Developments Address Skin

      Recent developments in optical coherence tomography (OCT) address skin cancer diagnosis. MedLumics (Madrid, Spain) has launched a three-year initiative to translate research into new clinical applications—with help from $4.9 million (€3.6 million) in Series A funding from EU joint investors. Called the BiopsyPen Project, the initiative is led by MedLumics and the Medical University of Vienna (Austria), along with European members including VTT Finland (Espoo, Finland), Delft University of Technology in The Netherlands, Exalos (Schlieren, Switzerland), the Polytechnic University of Madrid, and Optocap (Livingston, Scotland). The organizations are working to develop a handheld system for point-of-care diagnosis ...

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    23. Florida International University receives NIH grant for Multimodal Retinal Functional Imaging for Diabetic Retinopathy

      Florida International University receives NIH grant for Multimodal Retinal Functional Imaging for Diabetic Retinopathy

      Florida International University received a 2014 NIH grant for $547,068 for Multimodal Retinal Functional Imaging for Diabetic Retinopathy. The principle investigator was Shuliang Jiao. The program began in 2013 and ends in 2016. Below is a summary of the proposed work. Diabetic retinopathy (DR) is a leading cause of irreversible blindness among working-age adults, which is a typical type of ischemia driven retinal disease characterized by microvascular damage to the retina in patients with diabetes. DR progresses through a sequence of recognizable stages, which begin with structural and functional derangement of the retinal microcirculation even before the early clinical ...

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    24. Washington University Receives NIH Grant for Studying Mechanics of Early Brain and Eye Development

      Washington University Receives NIH Grant for Studying Mechanics of Early Brain and Eye Development

      Washington University Receives a 2014 NIH Grant for $332,591 for Studying Mechanics of Early Brain and Eye Development. The principle investigator is Larry Taber. The program beganin 2010 and ends in 2015. Below is a summary of the proposed work. In human embryos, the primary subdivisions of the brain (forebrain, midbrain, and hindbrain) are formed by the fourth week of gestation. During this time, the primitive eyes (optic vesicles) emerge as protrusions from the forebrain. The forms of these organs are highly conserved. Abnormalities in size and shape of the early brain are known to cause serious neurological disorders ...

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    1. (11 articles) National Institutes of Health
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    1. (1 articles) Michael A. Choma
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