1. Articles in category: Funding

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    1. University of Applied Sciences, Jena Receives a BMBF Grant to Establish a Interdomain Framwork for an AI-based OCT-Data Image Analysis

      University of Applied Sciences, Jena Receives a BMBF Grant to Establish a Interdomain Framwork for an AI-based OCT-Data Image Analysis

      The University of Applied Sciences, Jena has received a Federal Ministry of Education and Research (BMBF) grant for €799,558 to establish an Open Lab Framework for an AI-based interdomain OCT-Data analysis. The principal investigators are Prof. Dr. Dirk Schmalzried, Prof. Dr. Jens Bliedtner and Prof. Dr. Iwan Schie. Within the project 'OpenLab AI - OpenLab for Data Analysis and Applied AI' a cross-domain framework for the analysis and processing of optical tomographic image data will be developed, which can be used cross-domain for the investigation of material surfaces in the domain of manufacturing and quality assurance as well as in ...

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    2. DFG grants funding to quantify ocular blood flow

      DFG grants funding to quantify ocular blood flow

      The German research foundation provides support to the Pattern Recognition Lab’s ophthalmic imaging group, led by Stefan Ploner, in the amount of more than a quarter million Euro, over a 30-month funding period. With this meanwhile third grant, DFG continues to strengthen a long standing collaboration in OCT(A) motion correction and signal reconstruction between the pattern recognition lab at FAU, led by Prof. Andreas Maier; the Biomedical Optical Imaging and Biophotonics group at MIT, led by the inventor of OCT, Prof. James Fujimoto; and clinicians at the New England Eye Center, led by retinal specialist Prof. Nadia Waheed ...

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    3. Massachusetts General Hosptial Receives NIH Grant for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

      Massachusetts General Hosptial Receives NIH Grant for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

      Massachusetts General Hosptial Received a 2022 NIH Grant for $643,503 for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy. The principal investigator is Guillermo Tearney. Below is a summary of the proposed study. Esophageal adenocarcinoma (EAC) is a deadly cancer that is preceded by a metaplastic change called Barrett's esophagus (BE). It has long been thought that endoscopic screening for BE followed by endoscopic surveillance can significantly decrease the mortality of EAC. This unfortunately has not borne out as the cost and inconvenience of conscious sedation prohibits endoscopy from being used as a population-based ...

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    4. Duke University Receives NIH Grant for Robotic Point-of-Care OCT

      Duke University Receives NIH Grant for Robotic Point-of-Care OCT

      Duke University Received a 2022 NIH Grant for $97,825 for Robotic Point-of-Care OCT . The principal investigator is Mark Draelos. Below is a summary of the proposed study. The PI was previously funded by the F30 mechanism while completing the Duke Medical Scientist Training Program. He has since completed medical school and internship and now returns for a full-time research career. This career development proposal is an effective continuation of the PI’s prior mentored training and research experience and seeks to develop him into an independent investigator. The proposed project concerns the role of optical coherence tomography (OCT) in ...

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    5. University or Rochester Receives NIH Grant for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography

      University or Rochester Receives NIH Grant for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography

      University or Rochester Received a 2022 NIH Grant for $51,752 for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography. The principal investigator is Gary Ge. Below is a summary of the proposed study. The rapidly advancing field of “elastography” has had some major successes in answering basic science questions and improving clinical diagnostics and therapies. For example, increased liver stiffness is strongly correlated with advanced liver disease such as fibrosis, increased aortic stiffness has been linked with cardiovascular disease, and multiple cancers can be assessed with viscoelastic heterogeneity. Other studies have used ...

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    6. Duke University Receives NIH Grant for $504,051 for Secondary Data Analysis for Neonates with Retinal OCT Imaging

      Duke University Receives NIH Grant for $504,051 for Secondary Data Analysis for Neonates with Retinal OCT Imaging

      Duke University Received a 2022 NIH Grant for $257,350 for Secondary Data Analysis for Neonates with Retinal OCT Imaging. The principal investigator is Cynthia Toth. Below is a summary of the proposed study. The Secondary Data Analysis for Neonates with Retinal OCT Imaging includes data from 330 infant participants previously enrolled into prospective observational studies which included use of investigational OCT devices for imaging at the bedside. These data have been divided into two groups: the Retinopathy of Prematurity (ROP) Group and the Healthy Term Infant Group. The ROP Group consists of data from 239 preterm infants evaluated for ...

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    7. University of Illinois at Chicago Receives NIH Grant for Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy

      University of Illinois at Chicago Receives NIH Grant for Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy

      University of Illinois at Chiago Received a 2022 NIH Grant for $250,000 for Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy. The principal investigator is Xincheng Yao. Below is a summary of the proposed study. This is an administrative supplement application for the R01 project, entitled ‘Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy’ (R01EY030842). The purpose of this supplement application is to add artificial intelligence (AI) topic research for enhanced retinal image construction and automated artery-vein analysis. Potential impact of the proposed AI topic research is twofold: 1) to advance ...

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    8. Stevens Institute of Technology Receives NIH Grant for Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy

      Stevens Institute of Technology Receives NIH Grant for Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy

      Stevens Institute of Technology Received a 2022 NIH Grant for $504,051 for Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy (DR). The principal investigator is Jennifer Kang-Mieler. Below is a summary of the proposed study. Diabetic retinopathy (DR) is one of the most common complications associated with diabetes. Detection of clinical DR signs can take several years from the onset of diabetes; hence, the long preclinical phase should provide a window to apply interventions that can slow or prevent progression to clinical endpoint (mild to severe visual impairment). In fact, early detection and treatment of DR can prevent ...

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    9. New imaging technique could speed up development of eye disease treatments

      New imaging technique could speed up development of eye disease treatments

      Researchers have developed a simple and fast way to perform optoretinography, an imaging technique that measures light-induced functional activity in the eye's retina, the network of neurons in the back of our eyes responsible for detecting light and initiating vision. More than 50% of people in the U.S. over age 60 are affected by retinal diseases such as macular degeneration and diabetic retinopathy.

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    10. University of Houston Receives NIH Grant for Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel Function

      University of Houston Receives NIH Grant for Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel Function

      University of Houston Received a 2022 NIH Grant for $609,697 for Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel Function. The principal investigator is Kirill Larin. Below is a summary of the proposed study. The etiology of congenital brain growth anomalies is complex, but prenatal alcohol/ethanol and nicotine exposure (PEE/PNE) are common causal factors in the US and worldwide. Research has mainly focused on the growth deficits in neural stem cells (NSCs) and their progeny following PEE/PNE. However, we recently used high- resolution imaging to document that PEE results in ...

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    11. Stanford University Received a 2022 NIH Grant for development of a Human Ear Cellular Atlas

      Stanford University Received a 2022 NIH Grant for development of a Human Ear Cellular Atlas

      Stanford University Received a 2022 NIH Grant for $803,331 for for development of a Human Ear Cellular Atlas. The principal investigator is Alan Cheng. Below is a summary of the proposed study. Hearing and balance disorders disable nearly half a billion people worldwide, yet there are virtually no pharmacological or biological therapies for these disorders. This alarming state of medicine coexist with the brighter state of science where numerous therapeutic approaches have shown efficacy in animal models. This conundrum reflects the fact that there are important differences between animal models and humans, that we have an incomplete understanding of ...

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    12. University of Massachusetts, Amherst Receives NIH Grant for Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney Viability

      University of Massachusetts, Amherst Receives NIH Grant for Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney Viability

      University of Massachusetts, Amherst Received a 2022 NIH Grant for $671,945 for Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney Viability. The principal investigator is Yu Chen. Below is a summary of the proposed study. There is a worldwide shortage of kidneys for transplantation due mainly to the fact that there is no reliable means to determine the viability of kidneys available for transplant. There are unmet clinical needs to reduce the >8,000 deaths that occur each year from failures of finding viable kidney matches for transplant, to reduce the nearly 4- year time on donor ...

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    13. Praevium Research Inc Receives NIH Grant for Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging

      Praevium Research Inc Receives NIH Grant for Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging

      Praevium Research Inc Received a 2022 NIH Grant for $275,001 for Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging. The principal investigator is Vijaysekhar Jayaraman. Below is a summary of the proposed study. This proposal aims to enable a new generation of high-speed, low-cost, wavelength-flexible swept source optical coherence tomography (SS-OCT) imaging device technology targeting applications in dental imaging and based on microelectromechanical systems vertical cavity surface emitting lasers (MEMS-VCSELs) and planar lightwave circuits (PLCs). MEMS-VCSELs provide an unmatched combination of high and variable axial scan rate, dynamic single mode operation enabling ...

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    14. Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Received a 2022 NIH Grant for $385,500 for Multi-contrast dynamic optical imaging to advance live developmental biology. The principal investigator is Shang Wang. Below is a summary of the proposed study. Imaging is essential for the study of developmental biology. In particular, optical imaging, with its high resolution, has been making revolutionary impacts on our understanding of biological development. To a large degree, the imaging capability defines what can be studied in developmental biology. From 2D to 3D, from static to dynamic, advancements in optical imaging have enabled us to connect molecular genetics with volumetric ...

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    15. New York University School of Medicine Receives NIH Grant for Full Field OCT for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives NIH Grant for Full Field OCT for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Received a 2022 NIH Grant for $666,893 for Full Field OCT for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. Below is a summary of the proposed study. Glaucoma is a leading cause of vision morbidity and blindness worldwide. Early disease detection and sensitive monitoring of progression are crucial to allow timely treatment for preservation of vision. The introduction of ocular imaging technologies significantly improves these capabilities, but in clinical practice there are still substantial challenges at certain stages of the disease severity spectrum, specifically in the early ...

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    16. Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Received a 2022 NIH Grant for $548,978 for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging. The principal investigator is Nathan Dobel. Below is a summary of the proposed study. The proposed design and construction of an optical coherence tomography (OCT) system, namely, a full-field (FF)-swept-source (SS)-OCT will allow rapid structural and functional measures of individual cone and rod photoreceptors (PRCs), the sub-retinal space (SRS) and retinal pigment epithelial (RPE) cells to an external light stimulus. Current OCT systems either have limited temporal resolution i.e. they are not fast enough ...

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    17. University of Southern California Receives NIH Grant for Role of tonic outer hair cell motility in cochlear amplification

      University of Southern California Receives NIH Grant for Role of tonic outer hair cell motility in cochlear amplification

      University of Southern California Received a 2022 NIH Grant for $165,000 for Role of tonic outer hair cell motility in cochlear amplification. The principal investigator is James Dewey. Below is a summary of the proposed work. Mammalian hearing sensitivity depends on outer hair cells (OHCs), which change length and generate force to amplify sound-evoked vibrations within the cochlea. While it is often assumed that amplification depends on cycle-by-cycle OHC motility, the ability of this mechanism to operate at sufficiently high frequencies in vivo has been questioned, and exactly how OHCs interact with the surrounding organ of Corti structures to ...

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    18. Indiana University Receives NIH Grant for Imaging Structure and Function of Photoreceptors.

      Indiana University Receives NIH Grant for Imaging Structure and Function of Photoreceptors.

      Indiana University Received a 2022 NIH Grant for $577,031 for Imaging Structure and Function of Photoreceptors. The principal investigator is Donald Miller. Below is a summary of the proposed work. Human vision starts when photoreceptors collect and respond to light. Normal photoreceptor function is essential for normal vision, yet techniques to assess these processes in vivo are limited. New optical modalities that are rapid, specific, and non‐invasive promise to greatly expand our capability to monitor more accurately and completely photoreceptors. This study takes advantage of unique adaptive‐optics OCT instrumentation developed in my laboratory in conjunction with custom ...

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    19. Massachusetts General Hosptial Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hosptial Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hosptial Received a 2022 NIH Grant for $46,752 for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection. The principal investigator is Taylor Cannon. Below is a summary of the proposed work. Better imaging-based screening and surveillance methods stand to improve patient outcomes in cancers that are typically diagnosed at late stages, such as esophageal adenocarcinoma (EAC). Although success- ful proactive treatment options are available to patients diagnosed with low- or high-grade dysplasia, many at-risk patients are diagnosed at later stages with few effective treatment options, leading to high mortality rates. Dysplasia is diagnosed based ...

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    20. University of Southern California Receives NIH Grant for Long-wavelength 1.7-micron optical coherence tomography for otologic imaging and hearing research

      University of Southern California Receives NIH Grant for Long-wavelength 1.7-micron optical coherence tomography for otologic imaging and hearing research

      University of Southern California Received a 2022 NIH Grant for $67,582 for Long-wavelength 1.7-micron optical coherence tomography for otologic imaging and hearing research. The principal investigator is Jack Tang. Below is a summary of the proposed work. Hearing loss affects the quality of life in nearly one-in-four adults in the United States, yet in many cases it is difficult to identify the cause. CT imaging can provide high-resolution contrast in the small bony structures in the middle/inner ear, and MRI can provide medium-resolution contrast in soft tissues, but there exists a need for high-resolution imaging of the ...

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    21. Loma Linda Veterans Association Receives NIH Grant Role of Organ of Corti Outer Hair Cell/Vibration Hot Spots in Distortion Product Otoacoustic Emission Generation

      Loma Linda Veterans Association Receives NIH Grant Role of Organ of Corti Outer Hair Cell/Vibration Hot Spots in Distortion Product Otoacoustic Emission Generation

      Loma Linda Veterans Association Received a 2022 NIH Grant for $219,750 for Role of Organ of Corti Outer Hair Cell/Vibration Hot Spots in Distortion Product Otoacoustic Emission Generation. The principal investigator is Wei Dong. Below is a summary of the proposed work. Earlier research in our laboratory using interference tones (ITs) and vector-difference analyses between control and various experimental conditions established that large distortion product otoacoustic emissions (DPOAEs) components evidenced by strong enhancement and/or suppression, can arise from regions located up to several octaves basal to the f2 primary-tone. The proposed experiments in gerbils are focused on ...

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    22. University of California at Los Angeles Received a 2022 NIH Grant for $567,451 for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery

      University of California at Los Angeles Received a 2022 NIH Grant for $567,451 for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery

      University of California at Los Angeles Received a 2022 NIH Grant for $567,451 for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery. The principal investigator is Tsu-Chin Tsao. Below is a summary of the proposed work. The long-term goals of the present study are to improve surgical outcomes and reduce the risk of surgical complications of cataract surgery. It is our central hypothesis that intraoperative stabilization of the ocular structures, complete lens extraction, and accurate positioning of the intraocular lens implant through robotic manipulations and optical coherence tomography (OCT) feedback will significantly improve the safety of critical ...

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    23. Northwestern University Receives NIH Grant for Clinical glaucoma management enabled by visible-light OCT

      Northwestern University Receives NIH Grant for Clinical glaucoma management enabled by visible-light OCT

      Northwestern University Received a 2022 NIH Grant for $631,924 for Clinical glaucoma management enabled by visible-light OCT. The principal investigator is Hao Zhang. Below is a summary of the proposed work. This collaborative technology focused project seeks to develop, characterize, and validate visible-light optical coherence tomography (vis-OCT) as a functional tool to transform the clinical management of glaucoma. We will address two unmet needs in clinical glaucoma diagnosis and detection of progression: (1) the ability to measure retinal sublayer structure and (2) to accurately assess local retinal hemoglobin oxygen saturation (sO2). The earliest structural changes in glaucoma are thought ...

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    24. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Received a 2022 NIH Grant for $590,490 for Functional and Structural Optical Coherence Tomography for Glaucoma . The principal investigator is David Huang. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness in the US. The management of glaucoma is based on early detection, followed by careful evaluation and monitoring to identify those with rapid disease progression and high risk for vision loss. This allows for the rational use of medical, laser, and surgical treatments. Current methods of assessing glaucoma have significant limitations. Visual field (VF) testing has a low ...

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