1. Articles in category: Funding

    1-24 of 531 1 2 3 4 ... 21 22 23 »
    1. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of ...

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    2. Horizon 2020 project aims to transform optical coherence tomography

      Horizon 2020 project aims to transform optical coherence tomography

      Advances in silicon photonics development for datacom applications are set to be applied in biophotonics, with a new €4.9 million European project aiming to create a tiny and low-cost system for optical coherence tomography (OCT). While OCT has become widely used for ophthalmic diagnosis and is gaining traction in cardiovascular imaging, the technique still relies on relatively expensive and bulky combinations of laser, optical and electronic equipment. Now a team led by Wolfgang Drexler from the Medical University of Vienna is aiming to shrink the core technology to no more than the size of a coin, primarily to diagnose ...

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    3. Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives a 2016 NIH Grant for $742,986 for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function. The principal investigator is David Sosnovik. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. Pressure overload of the left and right ventricles initially leads to adaptive hypertrophy. This, however, is frequently followed by maladaptive hypertrophy, heart failure and death. We hypothesize here that changes in 3D myocardial fiber architecture play a significant role in the deleterious transition from adaptive to maladaptive hypertrophy and heart failure. We further hypothesize that ...

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    4. State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received a 2016 NIH Grant for $195,071 for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents. The principal investigator is Congwu Du. The program began in 2016 and ends in 2018. Below is a summary of the propose work. The medial prefrontal cortex (mPFC) plays a critical role in cocaine addiction. The mechanism underlying mPFC dysfunction in cocaine abusers are not well understood and could reflect disruption of cerebral blood flow (cocaine’s vascular effects) and/or disruption of dopaminergic modulation of the prefrontal cortex (cocaine’s ...

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    5. Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives a 2016 NIH Grant for $416,250 for Quantitative Optical Imaging of Cilia-Driven Fluid Flow. The principal investigator is Michael Choma. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Respiratory diseases are major causes of pediatric morbidity and mortality. These diseases are incompletely understood, which is a barrier to improving clinical care. Therefore, new mechanisms of disease need to be discovered. Optical imaging (e.g. optical coherence tomography [OCT]) will enable these discoveries since traditional imaging (e.g. x-ray, CT, MRI) cannot visualize structures smaller than ~1 mm ...

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    6. Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives a 2016 NIH Grant for $746,856 for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo. The principal investigator is Robert Brown. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. This Biomedical Research Partnership (BRP) proposal involves a partnership among a biomedical engineering team, a pulmonary physiology team, and a clinical pulmonary medicine team. This research program will incorporate state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human obstructive lung diseases (OLD). Optical coherence tomography (OCT) is ...

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    7. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives  NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      University of Illionois at Urbana-Champaign Receives a 2016 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investiagator is Stephen Boppart. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...

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    8. EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential

      EU Funded Careioca Projet Lead to New High-Speed Ex-Vivo and Endoscopic Optical Imaging Systems for Real-Time Cancer Diagnosis Showing High Potential

      Cancer diagnosis relies on the long and complex histology process. During surgery, there is currently no real- time guidance at the histology level, leading to up to 40% of reoperations . Along the cancer care workflow , in particular for tumor biopsy and excision, current existing preoperative and intraoperative imaging techniques fail to perform a reliable in situ diagnosis. Moreover, the complete pathological diagnosis, often based on histology slides preparation, is usually only available after a few days. For these reasons a significant number of patients need to undergo secondary biopsy or surgery. The CAReIOCA project combined the latest advances in CMOS ...

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    9. An implant to catch metastatic cancer cells before they grow into tumors

      An implant to catch metastatic cancer cells before they grow into tumors

      There could be a way around this, though: a special imaging method under development at Northwestern University called Inverse Spectroscopic Optical Coherence Tomography (ISOCT). ISOCT detects molecular-level differences in the way cells in the body scatter light. And when we scan our implant with ISOCT, the light scatter pattern looks different when it's full of normal cells than when cancer cells are present. In fact, the difference is apparent when even as few as 15 out of the hundreds of thousands of cells in the implant are cancer cells. There's a catch – ISOCT cannot penetrate deep into tissue ...

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    10. Oregon Health and Science University Receives NIH Grant for Ossicle Vibration Measurement sin Conductive Hearing Loss

      Oregon Health and Science University Receives NIH Grant for Ossicle Vibration Measurement sin Conductive Hearing Loss

      Oregon Health and Science University Receives a 2016 NIH Grant for $418,717 for Ossicle Vibration Measurement sin Conductive Hearing Loss. The principal investigator is Steven Jaques. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane. The system is based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to ¿m amplitude. In Aim ...

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    11. University of Iowa Receives NIH Grant for 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema

      University of Iowa Receives NIH Grant for 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema

      University of Iowa Receives a 2016 NIH Grant for $339,750 for 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema. The principal investigator is Mona Garvin. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Currently, the clinical assessment of optic nerve swelling is limited by the subjective ophthalmoscopic evaluation by experts in order to diagnose and differentiate the cause of the optic disc edema. The long-term goal of our research effort is to develop automated 3D image-analysis approaches for the identification of an optimal set of ...

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    12. Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2016 NIH Grant for $288,576 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

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    13. Massachusetts General Hospital Receives NIH Grant for Octology: Histology using Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Octology: Histology using Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2016 NIH Grant for $253,600 for Octology: Histology using Optical Coherence Tomography. The principal investigator is Burce Fischl. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. While histology remains the gold standard for assessing human neuroanatomy, the procedures for sectioning and hand mounting tissue for microscopic imaging are not substantially different than they were 100 years ago. These steps introduce irremediable distortions into the tissue sections making it difficult or impossible to align sections with suffiient accuracy to create 3D histological volumes at the micron ...

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    14. Columbia University Receives NIH Grant for Structural and Functional Progression for Glaucomatous Damage to Macula

      Columbia University Receives NIH Grant for Structural and Functional Progression for Glaucomatous Damage to Macula

      Columbia University Receives a 2016 NIH Grant for $400,000 for Structural and Functional Progression for Glaucomatous Damage to Macula. The principal investigator is Carlos De Moraes. The program began in 2015 and ends in 2018. Below is a summary of the proposed work. There is compelling evidence that glaucomatous damage to the macula occurs even in early stages of the disease. The macula comprises about 30% of all retinal ganglion cells and its information corresponds to over 50% of the visual cortex. However, glaucomatous damage to the macula is often missed in clinical practice. Some of the reasons are ...

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    15. University of California at Irvine Receives NIH Grant for Phased Resolved ARF optical Coherence Elastography for Intravascular Imaging

      University of California at Irvine Receives NIH Grant for Phased Resolved ARF optical Coherence Elastography for Intravascular Imaging

      University of California at Irvine Receives a 2016 NIH Grant for $721,594 for Phased Resolved ARF optical Coherence Elastography for Intravascular Imaging. The principal investigatoor is Zhonping Chen. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution ...

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    16. Northwestern University Receives a 2016 NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography

      Northwestern University Receives a 2016 NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography

      Northwestern University Receives a 2016 NIH Grant for $48,576 for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography. The principal investigator is Brian Soetikno. The program began in 2016 and ends in 2021. Below is a summary of the proposed work.

      The retina is one of the most metabolically active tissues in the human body, making it particularly susceptible to hypoxia. In diabetic retinopathy (DR), aberrant oxygen metabolism has been hypothesized to play a pivotal role its pathogenesis. An improved understanding of how imbalances in oxygen delivery and demand lead to the progression of DR ...

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    17. Iowa City Veterans Administration Medical Center Received a 2016 NIH Grant for Automated Assessment of Optical Edema with Low-Cost Imaging

      Iowa City Veterans Administration Medical Center Received a 2016 NIH Grant for Automated Assessment of Optical Edema with Low-Cost Imaging

      Iowa City Veterans Administration Medical Center Received a 2016 NIH Grant for Automated Assessment of Optical Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury, and from idiopathic causes. Currently, the diagnosis of papilledema and its severity are assessed by direct funduscopic observation or digital fundus photographs using a six-stage grading scale. The scale ...

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    18. Valery Tuchin Honored with Joseph W. Goodman Award for Book on Light Scattering Applications in Medical Diagnostics

      Valery Tuchin Honored with Joseph W. Goodman Award for Book on Light Scattering Applications in Medical Diagnostics

      Valery Tuchin of Saratov State University (SSU) is the recipient of the 2016 Joseph W. Goodman Book Writing Award for his book titled Light Scattering Methods and Instruments for Medical Diagnosis, 3rd ed., published by SPIE Press in 2015. The award is co-sponsored by SPIE, the international society for optics and photonics , and The Optical Society. The Goodman Award , a biennial award funded by a personal gift from Joseph W. and Hon Mai Goodman, recognizes a recent and outstanding book in the field of optics and photonics that has contributed significantly to research, teaching, or the optics and photonics industry ...

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    19. Five finalists compete for Nvidia 2016 Global Impact Award this week

      Five finalists compete for Nvidia 2016 Global Impact Award this week

      The fourth finalist group is Joseph Izatt and his team at Duke University for their work in using GPU-accelerated, real-time stereoscopic 3D data for eye surgery. A single Titan GPU takes a stream of raw “optical coherence tomography” (OCT) data, processes it, and renders 3D volumetric images. These images, at a resolution of a few micrometers, are projected into microscope eyepieces. With Nvidia 3D Vision-ready monitors and 3D glasses, live stereoscopic data can be viewed by both a surgeon using the microscope and a group observing the operation as it occurs. The blog post is titled “How GPUs Help Eye ...

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    20. MIT receives a NIH grant for Novel Diagnostics with Optical Coherence Tomography.

      MIT receives a NIH grant for Novel Diagnostics with Optical Coherence Tomography.

      Massachusetts Institute of Technology receives a 2016 NIH grant for $437,893 for Novel Diagnostics with Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1985 and ends in 2020. Below is a summary of the propose work. This proposal is a resubmission of a competing renewal application for an ongoing collaborative program among investigators at the Massachusetts Institute of Technology, New England Eye Center and University of Pittsburgh Medical Center Eye Center. This is a multidisciplinary program which integrates imaging technology research, clinical and small animal imaging studies. The specific aims are: Aim 1. Next ...

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    21. Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives NIH Grant  for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives a 2016 NIH Grant for $691,728 for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care. The principal investigator is Cynthia Toth. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that may impact vision in vulnerable preterm neonates for a lifetime. Clinical care of infants with ROP decreases the likelihood of blindness, but abnormal vision is common, especially in those with disease severe enough to require treatment. Because it has ...

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    22. Recanalization system using radiofrequency energy

      Recanalization system using radiofrequency energy

      A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. In this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

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      Mentions: Osamu Katoh
    23. Emanuel Hospital Receives a 2016 NIH Grant for Optic Nerve Head SD-OCT Imaging in Glaucoma

      Emanuel Hospital Receives a 2016 NIH Grant for Optic Nerve Head SD-OCT Imaging in Glaucoma

      Emanuel Hospital Receives a 2016 NIH Grant for $559,400 for Optic Nerve Head SD-OCT Imaging in Glaucoma. The principal investigator is Claude Burgoyne. The program began in 2010 and ends in 2017. Below is a summary of the proposed work. As a result of discoveries made during the first project period, we propose a paradigm change for clinical assessment of the Optic Nerve Head (ONH), peripapillary retinal nerve fiber layer (RNFL) and macula based on acquisition and regionalization of Spectral Domain Optical Coherence Tomography (SDOCT) ONH, RNFL and macula datasets relative to the axis between the center of Bruch ...

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