1. Articles in category: Funding

    1-24 of 913 1 2 3 4 ... 36 37 38 »
    1. Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives a 2021 NIH Grant for $582,395 for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging. The principal investigator is Nathan Doble. Below is a summary of the proposed work. The proposed design and construction of an optical coherence tomography (OCT) system, namely, a full-field (FF)-swept-source (SS)-OCT will allow rapid structural and functional measures of individual cone and rod photoreceptors (PRCs), the sub-retinal space (SRS) and retinal pigment epithelial (RPE) cells to an external light stimulus. Current OCT systems either have limited temporal resolution i.e. they are not fast enough ...

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    2. Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives a 2021 NIH Grant for $471,602 for OCT Angiography for Neovascular Age-related Macular Degeneration. The principal investigator is Yali Jia. Below is a summary of the proposed work. Neovascular age-related macular degeneration (AMD), characterized by the presence of choroidal neovascularization (CNV), accounts for the majority of AMD related vision loss. Invasive dye-based fluorescein angiography (FA) remains the gold standard for CNV detection. Using high-speed OCT systems, we have developed novel OCT angiography (OCTA) technologies to image CNV as well as vascular plexuses associated with AMD. Our recent clinical studies have demonstrated that (1 ...

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    3. Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hospital Receives a 2021 NIH Grant for $46,036 for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection. The principal investigator is Taylor Cannon. Below is a summary of the proposed work. Better imaging-based screening and surveillance methods stand to improve patient outcomes in cancers that are typically diagnosed at late stages, such as esophageal adenocarcinoma (EAC). Although success- ful proactive treatment options are available to patients diagnosed with low- or high-grade dysplasia, many at-risk patients are diagnosed at later stages with few effective treatment options, leading to high mortality rates. Dysplasia is diagnosed based ...

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    4. University of California at Los Angeles Receives NIH Grant for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery.

      University of California at Los Angeles Receives NIH Grant for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery.

      University of California at Los Angeles Receives a 2021 NIH Grant for $557,751 for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery. The principal investigator is Jean-Pierre Hubschman. Below is a summary of the proposed work. The long-term goals of the present study are to improve surgical outcomes and reduce the risk of surgical complications of cataract surgery. It is our central hypothesis that intraoperative stabilization of the ocular structures, complete lens extraction, and accurate positioning of the intraocular lens implant through robotic manipulations and optical coherence tomography (OCT) feedback will significantly improve the safety of critical ...

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    5. New England College of Optometry Receives NIH Grant for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo

      New England College of Optometry Receives NIH Grant for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo

      New England College of Optometry Receives a 2021 NIH Grant for $196,651 for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo. The principal investigator is Ji Change He. Below is a summary of the proposed work. The crystalline lens of the human eye grows throughout life with continuous change in its size, shape and internal structure. The lifetime growth of the lens generates a special structure inside the lens: the gradient distribution. From the lens surface to the lens center, the gradient distribution is characterized ...

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    6. Massachusetts General Hospital Receives NIH Grant for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT

      Massachusetts General Hospital Receives NIH Grant for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT

      Massachusetts General Hosptial Receives a 2021 NIH Grant for $199,976 for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT. The principal investigator is Benjamin Vakoc. Below is a summary of the proposed work. Despite advances in OCT technology over the past two decades, retinal OCT systems are still limited by their speed. This has many consequences on how OCT is used. Perhaps most significantly, current speeds restrict the imaged field to a fraction of the total retinal area. This prevents diseases of the peripheral retina from being imaged in routine OCT scans. Two recent technologies ...

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    7. University of Southern California Receives NIH Grant for Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives NIH Grant for Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives a 2021 NIH Grant for $193,633 for Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There is a growing interest in the development of functional imaging with Optical Coherence Tomography (OCT). Many of these approaches to functional imaging rely on the exquisite phase sensitivity of the OCT interferometer. These include well established techniques like Doppler OCT for measuring blood flow as well as emerging applications like OCT elastography for measuring mechanical properties, and Magnetomotive OCT and ...

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    8. Oregon Health & Science University Receives NIH Grant for Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma

      Oregon Health & Science University Receives NIH Grant for Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma

      Oregon Health & Science University Receives a 2021 NIH Grant for $500,718 for Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma. The principal investigator is Yali Jia. Below is a summary of the proposed work. Glaucoma damage to the optic nerve and impairment of vision are progressive and irreversible. Understanding mechanisms of glaucomatous injury will help to develop new approaches for treatments that can be used along with traditional therapies that lower intraocular pressure (IOP). Recent developments in optical coherence tomography (OCT) angiography have brought increased attention to the role of the inner retinal circulation ...

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    9. Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives a 2021 NIH Grant for $468,446 for Multi-contrast dynamic optical imaging to advance live developmental biology. The principal investigator is Shang Wang. Below is a summary of the proposed work. Imaging is essential for the study of developmental biology. In particular, optical imaging, with its high resolution, has been making revolutionary impacts on our understanding of biological development. To a large degree, the imaging capability defines what can be studied in developmental biology. From 2D to 3D, from static to dynamic, advancements in optical imaging have enabled us to connect molecular genetics with volumetric ...

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    10. New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives a 2021 NIH Grant for $468,446 for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography. The principal investigator is Vivek Srinivasan. Below is a summary of the proposed work. The earliest changes in the photoreceptors, retinal pigment epithelium, and Bruch’s membrane in age-related macular degeneration (AMD) are subtle and challenging to detect non-invasively. Here, we will develop and validate a new in vivo imaging technology, visible light Optical Coherence Tomography (OCT), which, if implemented carefully, delineates these layers with unprecedented depth resolution and functional contrast. The ability to precisely ...

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    11. Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives a 2021 NIH Grant for $468,446 for Enabling technology for image-guided robot-assisted sub-retinal injections. The principal investigator is Iulian Iordachita. Below is a summary of the proposed work. The goal of this proposal is to design, develop and evaluate a novel clinically compatible surgical platform for enhancing the retina surgeon's ability to provide therapy to the subretinal domain. Efficient, safe, reproducible delivery methods would enable safe and precise delivery of stem cell, nanoparticle and gene therapies for prevalent ocular diseases including but not limited to Age-related Macular Degeneration (AMD). The proposed cooperative surgical robot ...

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    12. PROSCOPE project aims for early-stage bowel cancer detection

      PROSCOPE project aims for early-stage bowel cancer detection

      Multimodal platform should allow cellular-level colon imaging in real-time. Improving diagnosis: PROSCOPE A project funded by the EU's Horizon 2020 program is on course to develop a new imaging system for the diagnosis of bowel cancer. PROSCOPE , officially titled "Point-of-care instrument for diagnosis and image-guided intervention of colorectal cancer," was launched in 2020 and backed by €6 million of EU funding. The project has now carried out an 18-month formal review, confirming that its research program is on target to help reduce the 160,000 deaths and €9 billion in healthcare costs associated with the disease. "Currently, only 14 ...

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    13. New imaging system to detect bowel cancer at the earliest stages using photonics

      New imaging system to detect bowel cancer at the earliest stages using photonics

      Early intervention could prevent many of the 160,000 deaths from colon cancer in Europe each year. Colonoscopies, the gold standard for spotting bowel cancer early, can still miss up to 20% of precancerous cells. But now, thanks to a pan-European health consortium, a new concept that uses photonics to help doctors spot bowel cancer could soon prevent up to half of these deaths and save €9 billion in reduced healthcare costs. No tools exist that can look inside the colon at the cellular level in real-time to give an immediate diagnosis. But now, this European research team based across ...

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    14. Countermeasures for Visual Impairment in Astronauts

      Countermeasures for Visual Impairment in Astronauts

      This study is being done to prevent changes in the vision of astronauts during prolonged residence on the International Space Station or a mission to Mars. This project will provide data about the efficacy of lower body negative pressure to mimic daily upright posture by intermittently lowering central venous pressure while in simulated microgravity (3 days of bed rest). The investigators expect that 3 days of bed rest will increase choroid thickness, and choroid area. The investigators hypothesize that nightly LBNP (-20mmHg) will prevent these changes.

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    15. University of Arizona Receives NIH Grant for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting

      University of Arizona Receives NIH Grant for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting

      University of Arizona Receives a 2021 NIH Grant for $693,571 for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting . The principal investigator is Rongguang Liang. Below is a summary of the proposed work. Oral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancer worldwide, accounting for 400,000 new cancer cases each year. Two-thirds of these cancers occur in low- and middle-income countries (LMICs). While the 5-year survival rate in the U.S. is 62%, the survival rate is only 10- 40% and cure rate around 30% in ...

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    16. University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement

      University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement

      University of North Carolina Receives a 2021 NIH Grant for $797,092 for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement. The principal investigator is Amy Oldenburg. Below is a summary of the proposed work. Subglottic stenosis (SGS) is one of the most common life-threatening airway disorders in infants and children. Current treatment methods are based on airway endoscopy, which provides only qualitative information. Surgical treatment failures for the most severe grades of SGS range toward 50%, often due to post-operative airway collapse in new, unpredicted locations. Treatment ...

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    17. MGH Receives NIH Grant for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging

      MGH Receives NIH Grant for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging

      Massachusetts General Hospital Receives a 2021 NIH Grant for $210,000 for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging. The principal investigator is Hui Wang. Below is a summary of the proposed work. Development of the human cerebellum undergoes a precisely programmed sequence of processes, spanning from the third trimester of pregnancy into the first postnatal year. Due to advances in neonatal imaging techniques, cerebellar injury has been increasingly detected in premature infants and full-terms with birth complications. Although perinatal cerebellar injury and malformation have been broadly associated with developmental delays in motor, language, cognition, and ...

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    18. University of Alabama Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama Receives NIH Grant  for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama at Birmingham Receives a 2021 NIH Grant for $258,726 for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease. The principal investigator is Yuqiang Bai. Below is a summary of the proposed work. In humans, the precorneal tear film (PCTF) is a thin layer (~3-5 µm) of a complex biological fluid coating the ocular surface, that serves to nourish and protect the ocular surface and provide a smooth refractive optical surface for vision. In dry eye disease, the PCTF becomes thinner, and destabilizes (evaporates ...

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    19. MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2021 NIH Grant for $198,000 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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    20. Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT evaluation to reveal early-stage changes in glaucoma

      Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT evaluation to reveal early-stage changes in glaucoma

      Legacy Emanuel Hospital and Health Center Receives a 2021 NIH Grant for $683,321 for Advancing OCT evaluation to reveal early-stage changes in glaucoma. The principal investigator is Brad Fortune. Below is a summary of the proposed work. Currently, diagnosis of glaucoma and patient management decisions are often informed by thinning of the optic nerve head (ONH) neuro-retinal rim, peripapillary retinal nerve fiber layer (RNFL), and macular inner retinal layers, as detected using optical coherence tomography (OCT). These measurements are useful because they are predictive of subsequent visual field decline, and of faster rates of subsequent thinning. However, by the ...

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    21. Washington University Receives NIH Grant for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids

      Washington University Receives NIH Grant for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids

      Washington University Receives a 2021 NIH Grant for $347,287 for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids. The principal investigator is Chao Zhou. Below is a summary of the proposed work. More than 90% of the drugs being developed fail because of lack of efficacy or unexpected toxicity in clinical trials. This failure rate in the late stages of clinical development is in large part due to the use of overly simplistic in vitro cell assays, and in vivo animal models with limited predictive value during the various stages ...

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    22. Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives a 2021 NIH Grant for $683,321 for Optically guided catheter ablation of atrial fibrillation. The principal investigator is Andrew Rollins. Below is a summary of the proposed work. Atrial fibrillation (AF) affects approximately 3 million patients and its prevalence is expected to rise as the population ages. Catheter ablation, the preferred treatment strategy for symptomatic patients, creates local regions of tissue necrosis in the atria called lesions that are meant to abolish abnormal electrical activity that causes AF. However, AF recurrence is significant in these patients mostly due to inadequate lesions formed by ablation ...

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    23. UCSD Receives NIH Grant for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

      UCSD Receives NIH Grant for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

      University of California at San Diego Receives a 2021 NIH Grant for $117,347 for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography . The principal investigator is Mark Christopher. Below is a summary of the proposed work. Primary open angle glaucoma (POAG) is a leading cause of blindness in the United States and worldwide. It is estimated that over 2.2 million Americans suffer from POAG and that over 130,000 are legally blind from the disease. As the population ages, the number of people with POAG in the United States will increase ...

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    24. Robotic Scanner Automates Diagnostic Imaging in the Eye

      Robotic Scanner Automates Diagnostic Imaging in the Eye

      Engineers and ophthalmologists at Duke University have developed a robotic imaging tool that can automatically detect and scan a patient’s eyes for markers of different eye diseases. The new tool, which combines an imaging scanner with a robotic arm, can automatically track and image a patient’s eyes in less than a minute, and produce images that are as clear as the traditional scanners in specialized eye clinics. Their paper appeared July 12 in Nature Biomedical Engineering. Physicians and researchers use optical coherence tomography, or OCT, to diagnose various diseases in the eye, including glaucoma, diabetic retinopathy and age-related ...

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