1. Articles in category: Funding

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    1. PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare, a medical device company headquartered in Champaign, Illinois, received a $2.1 million award through the National Institute of Health (NIH) Phase llb Small Business Innovation Research (SBIR) program. The National Institute of Deafness & Communications Disorders (NIDCD), part of the NIH, is funding this award. The NIDCD conducts and supports research in the normal and disordered processes of hearing, balance, taste, smell, voice, speech, and language. In fiscal years 2015 and 2016 PhotoniCare was awarded SBIR Phase ll funding from the NIDCD. The SBIR program is the mechanism by which the NIH and other Federal agencies bring innovative solutions ...

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    2. Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first waveguide receives the first radiation, and the second waveguide receives the second radiation. The first arrangement, the second arrangement and the configuration can be housed in a probe.

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    3. OCTLIGHT Closes Investment Round on Path to Commercialize OCT Swept Source

      OCTLIGHT Closes Investment Round on Path to Commercialize OCT Swept Source

      OCTLIGHT secures funding years ahead upon successful reaching key milestone OCTLIGHT ApS announces that it has closed an investment round following the successful completion of milestones towards commercializing OCT swept source modules. The funding, which was closed according to plan, will cover the activities of OCTLIGHT over the coming years, focused on development of OCT swept source modules for Ophthalmology as the primary market. Wavelength tuning range doubled to 52 nm showing path towards goal of 100 nm OCTLIGHT has achieved significant milestones towards bringing OCT swept source modules to market. The development of the core VCSEL technology continues, with ...

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    4. Visualization of corneal vascularization in peripheral hypertrophic subepithelial corneal opacification with OCT angiography

      Visualization of corneal vascularization in peripheral hypertrophic subepithelial corneal opacification with OCT angiography

      Purpose The major goal of this study was to test the hypothesis that in patients with peripheral hypertrophic subepithelial corneal opacification (PHSCO), visualization of corneal vessels is better with optical coherence tomography angiography (OCTA) than with conventional slit lamp microphotography. Methods Patients with PHSCO were included in this prospective study. The corneal findings were photographed using a slit lamp camera (Haag Streit BM 900 ® ) and visualized with anterior‐segment OCT (Optovue XR Avanti, Fremont, California, USA). Additionally, OCTA with the Angiovue Imaging™ System was performed in the area of PHSCO. Results Thirty‐four eyes of 19 patients (26% male and ...

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      Mentions: Optovue Haag-Streit
    5. Systems and methods for ocular anterior segment tracking, alignment, and dewarping using optical coherence tomography

      Systems and methods for ocular anterior segment tracking, alignment, and dewarping using optical coherence tomography

      The present application discloses methods and systems to track the anterior segment while establishing a position of the delay which will permit good control of the placement of anterior segment structures. This allows accurate dewarping by maximizing the amount of corneal surface that is imaged as well as reducing or eliminating overlap between real and complex conjugate images present in frequency-domain optical coherence tomography. A method to dewarp surfaces given partial corneal surface information is also disclosed.

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    6. Apparatus and method of image registration

      Apparatus and method of image registration

      A method for bringing an IVUS and an OCT image into register. In one embodiment, the method includes obtaining an IVUS image of an area of a lumen; obtaining an OCT image of the same area of the lumen; determining the same asymmetry in each of the IVUS and OCT images; and overlaying the IVUS and OCT images and rotating them with respect to one another until the asymmetry in each of the IVUS and OCT images are in register, and determining the angle of rotation that resulted in the registration. In another aspect, the invention relates to a probe ...

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    7. Wavelength encoded multi-beam optical coherence tomography

      Wavelength encoded multi-beam optical coherence tomography

      Optical coherence tomography (OCT) apparatuses and methods include a first electro-magnetic radiation (EMR) source providing EMR to a first optical path associated with a sample and a second optical path associated with a reference. A multi-beam generator unit (MBGU) generates first and second EMR beams having different wavelength contents. A scanning system illuminates the sample with the first and second EMR beams, at a first and second time, at a first and second location. An interference module generates interference signals based on received EMR returning from the reference and the first and second EMR beams returning from the sample. A ...

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    8. Systems, methods and apparatuses for real-time anastomosis guidance and surgical evaluation using optical coherence tomography

      Systems, methods and apparatuses for real-time anastomosis guidance and surgical evaluation using optical coherence tomography

      A surgical evaluation and guidance system for use in extravacular evaluation and guidance of fluid vessel surgeries, includes an optical coherence tomography engine; a vessel probe optically coupled to the optical coherence tomography engine; and a signal processing and display system adapted to communicate with the optical coherence tomography engine to receive imaging signals therefrom. An optical coherence tomography vessel probe for use in extravacular evaluation and guidance of fluid vessel surgeries, includes a probe body having a proximal end and a distal end; an optical relay system disposed within the probe body; and a vessel adapter at least one ...

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    9. University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives a 2017 NIH Grant for $78,500 for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue. The principal investigator is Benjamin Sherlock. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. Cardiovascular disease is a leading cause of death globally. In vitro engineering of replacement blood vessels has emerged as a promising area of research that has the potential to provide lifesaving therapy in patients where autologous bypass grafts are not possible. The challenges of vascular tissue engineering require the developing samples ...

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    10. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives a 2017 NIH Grant for $225,116 for Method for Accurate Retinal Oxygen Metabolic Rate Extraction. The principal investigator is Wenzhong Liu. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. DR is a secondary complication of diabetes and a leading cause of blindness in the world. Although it is well known that DR is driven by ischemia, the current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non-proliferative DR and angiogenesis in proliferative DR. As a result, when ...

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    11. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant  for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives a 2017 NIH Grant for $559,269 for Functional and Structural Optical Coherence Tomography for Glaucoma. The principal investigator is David Huang. The program began in 2013 and ends in 2021. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnosis and close monitoring of glaucoma are important because the onset is insidious and the damage is irreversible. Advanced imaging modalities such as optical coherence tomography (OCT) have been used in the past 2 decades to improve the objective evaluation of glaucoma. OCT has higher axial spatial resolution ...

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    12. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of treating these devastating diseases is a formidable task. Nevertheless, trials examining novel therapeutic strategies are underway. An important key to success in the early phases of such trials is selection ...

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    13. Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives a 2017 NIH Grant for $25,000 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system for use in point of care settings. The target system price will be one third the price of currently available research OCT system while providing system performance comparable to other entry level OCT imaging systems. By breaking ...

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    14. Massachusetts General Hospital Receives NIH Grant The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2017 NIH Grant for $171,000 The Center for Biomedical OCT Research and Translation. The principal investogator is Brett Bouma. THe progbram began in 2017 and ends in 2018. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource will ...

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    15. Iowa City VA Receives NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging

      Iowa City VA  Receives NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging

      Iowa City VA Medical Center Receives a 2017 NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury, and from idiopathic causes. Currently, the diagnosis of papilledema and its severity are assessed by direct funduscopic observation or digital fundus photographs using a six-stage grading scale. The scale ...

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    16. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography (OCT ...

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    17. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2017 NIH Grant for $37,696 Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for activation ...

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    18. Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives a 2017 NIH Grant for $139,730 for Imaging Structure and Function. The principal investigator is Thomas Clandinin. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Imaging technologies such as confocal microscopy, multiphoton microscopy and super- resolution imaging as well as optical coherence tomography have transformed the ability of scientists to observe structural and functional changes in the visual system, in vivo and ex vivo, in both health and disease. The overarching goal of the imaging core is to transform the ability of vision scientists to use these ...

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    19. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives a 2017 NIH Grant $317,544 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion from ...

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    20. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives a 2017 NIH Grant for $616,301 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography (OCT ...

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    21. University of Miami Receives NIH Grant f for Dynamics of the Aging Ciliary Muscle

      University of Miami Receives NIH Grant f for Dynamics of the Aging Ciliary Muscle

      The long-term goal of this project is to enable the development of more effective treatments for presbyopia, the loss of near vision with age, by providing new insight into the mechanism behind presbyopia. The prevailing theory suggests that presbyopia is due mainly to age-related changes in the stiffness of the lens, but alternative theories have been proposed suggesting that age-related changes in the ciliary muscle may play a significant role. Age-related changes in the function of the ciliary muscle have been difficult to characterize in vivo due to the lack of suitable clinical imaging technology. The project will address two ...

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    22. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant  for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2017 NIH Grant for $1,191,714 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease. The principal investigator is Danny Wang. The program began in 2016 and ends in 2018. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are ...

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    23. Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives a 2017 NIH Grant for $50,000 Quantitative Imaging of Collagen Morphology in Human Scars. The principal investigator is Martin Villiger. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The overall goal of the proposed research is to develop and validate high-resolution birefringence imaging. The intrinsic birefringence of collagen offers an attractive contrast mechanism to investigate the collagen morphology in human skin and scars. Non-invasive characterization of the collagen organization in scar tissue would facilitate clinical trials that investigate novel therapeutic approaches to reduce scarring by providing ...

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    24. Physical Sciences, Incorporated Receives NIH Grant for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Physical Sciences, Incorporated Receives NIH Grant  for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Physical Sciences, Incorporated Receives a 2017 NIH Grant for $525,207 for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins. The principal investigator is Nicusor Iftima. The program began in 2014 and end sin 2019. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) and Caliber ID, Rochester, NY proposes to develop a novel technology for real-time assessment of surgical margins on breast cancer lumpectomy specimens and provide immediate feedback to the surgeon. A multimodal microscope will be used in conjunction with a high sensitivity cancer targeting agent ...

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