1. Articles in category: Pulmonology

    193-216 of 231 « 1 2 3 4 5 6 7 8 9 10 »
    1. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

      The ability to measure airway dimensions is important for clinicians, interventional bronchoscopists and researchers in order to accurately quantify structural abnormalities and track their changes over time or in response to treatment. Most quantitative airway measurements are based on X-ray computed tomography and, more recently, on multidetector computed tomography. Quantitative bronchoscopic techniques have also been developed, although these are less widely employed. Emerging techniques, including magnetic resonance imaging, endoscopic optical coherence tomography, endobronchial ultrasound and confocal endomicroscopy, provide new research tools with potential clinical applications. An understanding of issues related to the acquisition, processing and analysis of images, and how ...
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    2. Multimodality bonchoscopic imaging of tracheopathica osteochondroplastica

      Results of a commercial optical coherence tomography system used as part of a multimodality diagnostic bronchoscopy platform are presented for a 61-year-old patient with central airway obstruction from tracheopathica osteochondroplastica. Comparison to results of white-light bronchoscopy, histology, ... [J. Biomed. Opt. 14, 034035 (2009)] published Thu Jun 25, 2009.
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    3. A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)

      A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)
      The present disclosure provides a method of providing quantitative information about a property of the lower airways of a lung using optical coherence tomography. The method comprises inserting a probe head of an anatomical optical coherence tomography device into the lower airways. Further, the method comprises directing light to, and receiving reflected light from, an internal wall portion of the lower airways. The light is suitable for optical coherence tomography. An electronic signal indicative of a phase difference between reference light and the received light is then generated. In addition the method comprises determining a quantity associated with a property ...
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    4. Respiratory gating of anatomical optical coherence tomography images of the human airway

      Respiratory gating of anatomical optical coherence tomography images of the human airway
      Anatomical optical coherence tomography (aOCT) is a longrange endoscopic imaging modality capable of quantifying size and shape of the human airway. A challenge to its in vivo application is motion artifact due to respiratory-related movement of the airway walls. This paper represents the first demonstration of respiratory gating of aOCT airway data, and introduces a novel error measure to guide appropriate parameter selection. Results indicate that at least four gates per respiratory cycle should be used, with only minor improvements as the number of gates is further increased. It is shown that respiratory gating can substantially improve the quality of ...
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    5. Gender Differences in Airway Wall Measurements with Optical Coherence Tomography (OCT).

      Purpose: To examine the difference in the relationship between airway wall dimensions and lung function in male and female smokers. Methods: 35 male and 18 female subjects from the BC Lung Health Cohort, who underwent OCT imaging and spirometry, were studied. OCT images, acquired at the time of bronchoscopy, were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis software on 5 consecutive frames when the airway attained the diameter of the OCT probe (1.5mm) Lung function, represented by FEV1% predicted, was plotted against the wall area percent ...

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    6. Inter- and Intra-Observer Variability in Measurements of Airways Using Optical Coherence Tomography (OCT).

      Purpose: To devise a protocol for the measurement of airways using optical coherence tomography (OCT) with acceptable inter− and intra−observer variability. Methods: 59 subjects from the British Columbia Lung Health Cohort who underwent OCT imaging were studied. OCT images, acquired at the time of bronchoscopy were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis software on 5 consecutive frames when the probe was located in an airway with the same diameter as the probe (1.5mm). The airway lumen and wall areas were measured using the circular ...

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    7. Feature Of The Week 3/1/09: Optical Coherence Tomography to Improve Diagnostic and Therapeutic Bronchoscopy

      Feature Of The Week 3/1/09: Optical Coherence Tomography to Improve Diagnostic and Therapeutic Bronchoscopy
      Feature Of The Week 3/1/09: Ophthalmic and Cardiovascular applications are two of the leading commercialized areas of OCT. There are an ever increasing number of applications poised to make the successful transition to commercialization thanks to progress by researchers around the world. One such area is Bronchoscopy where, for example, researchers at University of Western Australia and Sir Charles Gairdner Hospital have been very active. A recent publication by Jonathan P. Williamson et al presents new work on anatomical optical coherence tomography to accurately measure diameter and lumen area of the central airways during bronchoscopy. This study describes ...
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    8. Elastin peptides increase lung cancer cell growth in 3D models

      The lung is an organ heavily involved in cancer as both the origin of lung cancer and where metastases from tumours originating in other organs develop. Therefore, it is obvious that the interaction between cancer cells and lung tissue plays a role in cancer development, invasion, and/or growth. Out of all the components of the lung's extracellular matrix, elastin fragmentation products, the so-called elastin peptides, have been associated with tumour growth and invasion. Therefore, we studied using a 3D model whether elastin peptides could increase the proliferative activity of lung cancer cells. To this purpose, we grew lung ...
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      Mentions: Ying Yang
    9. Using Optical Coherence Tomography To Improve Diagnostic and Therapeutic Bronchoscopy

      Background Flexible bronchoscopy is a common procedure used in both diagnostic and therapeutic settings but does not readily permit measurement of central airway dimensions. Anatomical optical coherence tomography (aOCT), a modification of conventional optical coherence tomography (OCT), is a novel, light-based imaging tool with the capacity to accurately measure diameter and lumen area of the central airways during bronchoscopy. This study describes the first clinical use of anatomical optical coherence tomography in the lower airways in three individuals with common endobronchial pathologies. Methods During bronchoscopy, a specialized fiber-optic probe was passed through the biopsy channel of a standard flexible bronchoscope ...
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    10. Three-dimensional Imaging of subpleural Alveoli by Fourier Domain Optical Coherence Tomography

      Understanding alveolar mechanics is essential to improve artificial ventilation strategies and hence minimize ventilator associated lung injury. The investigation of alveolar geometry changes during ventilation was performed by intravital microscopy (IVM) and 3D Fourier domain optical coherence tomography (3D-OCT) in an in-vivo mouse model and in isolated, perfused and ventilated rabbit lungs. Air pocket size of individual alveoli was quantified in the en-face view. For both imaging techniques, IVM and 3D-OCT, subpleural air-pocket size was positively correlated with the applied airway pressure (endinspiratory pressure or continuous positive airway pressure, respectively). No alveolar recruitment/derecruitment was observed. We conclude that in ...
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    11. Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention

      (Article in Romanian) Early diagnosis of pulmonary cancer is crucial in the fight against this disease. Pre-neoplastic bronchial lesions are the first stage in the evolution towards invasive cancers. This paper describes histological patterns of these pre-neoplastic bronchial lesions, as well as early, intermediate and late molecular disturbancies associated with this condition. The ways to early identification of these lesions are: a) bronchoscopy with laser-induced auto-fluorescence guided through Optical Coherence Tomography, which is able to identify celular and extracelular structures, from the celular surface or beneath it; b) PET-CT which identifies lesions over 6 mm; c) bio-markers: the sensitivity of ...
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    12. Effect of Body Posture on Pharyngeal Shape and Size in Adults With and Without Obstructive Sleep Apnea

      Study Objectives: In patients with obstructive sleep apnea (OSA), the severity and frequency of respiratory events is increased in the supine body posture compared with the lateral recumbent posture. The mechanism responsible is not clear but may relate to the effect of posture on upper airway shape and size. This study compared the effect...
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    13. Tomophase to Exhibit First In-vivo Cross-sectional Images of Pulmonary Stenting Using Proprietary OCT System

      Tomophase to Exhibit First In-vivo Cross-sectional Images of Pulmonary Stenting Using Proprietary OCT System
      Results to be displayed at CHEST meeting in October BURLINGTON, Mass., Oct. 21 /PRNewswire/ -- Tomophase Corporation announced today that it will display the first in-vivo cross-sectional images of implanted pulmonary stents using their proprietary optical coherence tomography (OCT) system at the CHEST meeting in Philadelphia, Oct. 27th through Oct. 29th. The images were captured using the Tomophase OCT System as part of an ongoing research collaboration with Dr. Armin Ernst, Director of Interve
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    14. Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway

      Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
      Endoscopic treatment of lower airway pathologies requires accurate quantification of airway dimensions. We demonstrate the application of a real-time endoscopic optical coherence tomography system that can image lower airway anatomy and quantify airway lumen dimensions intra-operatively. Results ... [Opt. Express 16, 17521-17529 (2008)]
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    15. Optical Coherence Tomography of the Airway in Detecting Abnormal Cells in Patients Undergoing Surgery for Lung Cancer or Lung Disease

      RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells. PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease. OBJECTIVES: Correlate optical coherence tomography images of the airway with airway histology. Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer. OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on ...
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    16. Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor

      Jianping Su, Jun Zhang, Lingfeng Yu et al. A fast-scan-rate swept laser for optical coherence tomography (OCT) is suitable to record and analyze a 3-D image volume. However, the whole OCT system speed is limited by data streaming, processing, and storage. In this case, postprocessing is a common technique. Endoscopic clinical applications pr ... [J. Biomed. Opt. 13, 030506 (2008)] published Tue Jul 1, 2008.
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    17. In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model

      Matthew Brenner, Kelly Kreuter, Johnny Ju et al. Smoke inhalation injury causes acute airway injury that may result in airway compromise with significant morbidity and mortality. We investigate the ability of high resolution endobronchial optical coherence tomography (OCT) to obtain real-time images for quantitatively assessing regional difference ... [J. Biomed. Opt. 13, 034001 (2008)] published Mon Jun 23, 2008.
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    18. Optical Coherence Tomography of the Newborn Airway

      Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 μm). We examined the ability of this noninvasive technique to characterize the newborn airway in ...
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    193-216 of 231 « 1 2 3 4 5 6 7 8 9 10 »
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