1. Articles in category: Pulmonology

    217-240 of 243 « 1 2 ... 7 8 9 10 11 »
    1. Elastin peptides increase lung cancer cell growth in 3D models

      The lung is an organ heavily involved in cancer as both the origin of lung cancer and where metastases from tumours originating in other organs develop. Therefore, it is obvious that the interaction between cancer cells and lung tissue plays a role in cancer development, invasion, and/or growth. Out of all the components of the lung's extracellular matrix, elastin fragmentation products, the so-called elastin peptides, have been associated with tumour growth and invasion. Therefore, we studied using a 3D model whether elastin peptides could increase the proliferative activity of lung cancer cells. To this purpose, we grew lung ...
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      Mentions: Ying Yang
    2. Using Optical Coherence Tomography To Improve Diagnostic and Therapeutic Bronchoscopy

      Background Flexible bronchoscopy is a common procedure used in both diagnostic and therapeutic settings but does not readily permit measurement of central airway dimensions. Anatomical optical coherence tomography (aOCT), a modification of conventional optical coherence tomography (OCT), is a novel, light-based imaging tool with the capacity to accurately measure diameter and lumen area of the central airways during bronchoscopy. This study describes the first clinical use of anatomical optical coherence tomography in the lower airways in three individuals with common endobronchial pathologies. Methods During bronchoscopy, a specialized fiber-optic probe was passed through the biopsy channel of a standard flexible bronchoscope ...
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    3. Three-dimensional Imaging of subpleural Alveoli by Fourier Domain Optical Coherence Tomography

      Understanding alveolar mechanics is essential to improve artificial ventilation strategies and hence minimize ventilator associated lung injury. The investigation of alveolar geometry changes during ventilation was performed by intravital microscopy (IVM) and 3D Fourier domain optical coherence tomography (3D-OCT) in an in-vivo mouse model and in isolated, perfused and ventilated rabbit lungs. Air pocket size of individual alveoli was quantified in the en-face view. For both imaging techniques, IVM and 3D-OCT, subpleural air-pocket size was positively correlated with the applied airway pressure (endinspiratory pressure or continuous positive airway pressure, respectively). No alveolar recruitment/derecruitment was observed. We conclude that in ...
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    4. Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention

      (Article in Romanian) Early diagnosis of pulmonary cancer is crucial in the fight against this disease. Pre-neoplastic bronchial lesions are the first stage in the evolution towards invasive cancers. This paper describes histological patterns of these pre-neoplastic bronchial lesions, as well as early, intermediate and late molecular disturbancies associated with this condition. The ways to early identification of these lesions are: a) bronchoscopy with laser-induced auto-fluorescence guided through Optical Coherence Tomography, which is able to identify celular and extracelular structures, from the celular surface or beneath it; b) PET-CT which identifies lesions over 6 mm; c) bio-markers: the sensitivity of ...
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    5. Effect of Body Posture on Pharyngeal Shape and Size in Adults With and Without Obstructive Sleep Apnea

      Study Objectives: In patients with obstructive sleep apnea (OSA), the severity and frequency of respiratory events is increased in the supine body posture compared with the lateral recumbent posture. The mechanism responsible is not clear but may relate to the effect of posture on upper airway shape and size. This study compared the effect...
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    6. Tomophase to Exhibit First In-vivo Cross-sectional Images of Pulmonary Stenting Using Proprietary OCT System

      Tomophase to Exhibit First In-vivo Cross-sectional Images of Pulmonary Stenting Using Proprietary OCT System
      Results to be displayed at CHEST meeting in October BURLINGTON, Mass., Oct. 21 /PRNewswire/ -- Tomophase Corporation announced today that it will display the first in-vivo cross-sectional images of implanted pulmonary stents using their proprietary optical coherence tomography (OCT) system at the CHEST meeting in Philadelphia, Oct. 27th through Oct. 29th. The images were captured using the Tomophase OCT System as part of an ongoing research collaboration with Dr. Armin Ernst, Director of Interve
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    7. Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway

      Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
      Endoscopic treatment of lower airway pathologies requires accurate quantification of airway dimensions. We demonstrate the application of a real-time endoscopic optical coherence tomography system that can image lower airway anatomy and quantify airway lumen dimensions intra-operatively. Results ... [Opt. Express 16, 17521-17529 (2008)]
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    8. Optical Coherence Tomography of the Airway in Detecting Abnormal Cells in Patients Undergoing Surgery for Lung Cancer or Lung Disease

      RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells. PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease. OBJECTIVES: Correlate optical coherence tomography images of the airway with airway histology. Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer. OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on ...
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    9. Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor

      Jianping Su, Jun Zhang, Lingfeng Yu et al. A fast-scan-rate swept laser for optical coherence tomography (OCT) is suitable to record and analyze a 3-D image volume. However, the whole OCT system speed is limited by data streaming, processing, and storage. In this case, postprocessing is a common technique. Endoscopic clinical applications pr ... [J. Biomed. Opt. 13, 030506 (2008)] published Tue Jul 1, 2008.
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    10. In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model

      Matthew Brenner, Kelly Kreuter, Johnny Ju et al. Smoke inhalation injury causes acute airway injury that may result in airway compromise with significant morbidity and mortality. We investigate the ability of high resolution endobronchial optical coherence tomography (OCT) to obtain real-time images for quantitatively assessing regional difference ... [J. Biomed. Opt. 13, 034001 (2008)] published Mon Jun 23, 2008.
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    11. Optical Coherence Tomography of the Newborn Airway

      Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 μm). We examined the ability of this noninvasive technique to characterize the newborn airway in ...
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    12. Respiratory gating of endoscopic OCT images of the upper airway

      Robert A. McLaughlin, Julian J. Armstrong, Sven Becker et al. Anatomical optical coherence tomography (aOCT) is an endoscopic imaging modality that can be used to quantify size and shape of the upper airway. We report the application of respiratory gating to aOCT images. Our results show that respiratory gating can reduce motion artefact in upper airway images ... [Proc. SPIE 7004, 70045V (2008)] published Fri May 16, 2008.
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    13. Anatomical Optical Coherence Tomography for Long-Term, Portable, Quantitative Endoscopy

      n this paper, we report on anatomical optical coherence tomography, a catheter-based optical modality designed to provide quantitative sectional images of internal hollow organ anatomy over extended observational periods. We consider the design and performance of an instrument and its initial intended application in the human upper airway for the characterization of obstructive sleep apnea (OSA). Compared with current modalities, the technique uniquely combines quantitative imaging, bedside operation, and safety for use over extended periods of time with no cumulative dose limit. Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record ...
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    14. In vivo Optical Coherence Tomography Imaging of Preinvasive Bronchial Lesions

      Purpose: Optical coherence tomography (OCT) is an optical imaging method that can visualize cellular and extracellular structures at and below tissue surface. The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy. Experimental Design: A 1.5-mm fiberoptic probe was inserted via a bronchoscope into the airways of 138 volunteer heavy smokers participating in a chemoprevention trial and 10 patients with lung cancer to evaluate areas that were found to be normal or abnormal on autofluorescence bronchoscopy. Radial scanning of the airways was done to generate OCT images ...
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    15. Optical Biopsy Characterizing Tissue While Its in the Body

      Cover Story Table of Contents E-Newsletter Article Archive Editorial Calendar Datebook Writers' Guidelines Orgs/Links Opinion Polls Reprints Forum Lung cancer patients face the possibility that it could be more than two months from the time their cancer is first suspected from a chest x-ray or CT or PET scan until their diagnosis is confirmed and treatment begun. “By the time the patients go through six different appointments and getting this test and that, it could be 70 to 80 days until they a
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    16. Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography

      Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography

      Rationale: Computed tomography (CT) has been shown to reliably measure the airway wall dimensions of medium to large airways. Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less. Objectives: To correlate OCT measurements of airway dimensions with measurements assessed using CT scans and lung function. Methods: Forty-four current and former smokers received spirometry, CT scans, and OCT imaging at the time of bronchoscopy. Specific bronchial segments were identified and measured using the OCT images and three-dimensional reconstructions of the bronchial tree using CT. Measurements and Main ...

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    17. Anatomical optical coherence tomography: a safe and effective tool for quantitative long-term monitoring of upper airway size and shape

      J. J. Armstrong, S. Becker, R. A. McLaughlin et al. Anatomical optical coherence tomography (aOCT) is an endoscopic optical technique that enables continuous, quantitative assessment of hollow organ size and shape in three dimensions. It is a powerful alternative to X-ray computed tomography, magnetic resonance imaging, and video endoscopy for the as ... [Proc. SPIE Int. Soc. Opt. Eng. 6842, 68421N (2008)] published Fri Feb 8, 2008.
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    18. Imaging of the Pediatric Airway Using Optical Coherence Tomography.

      Laryngoscope. 117(12):2206-2212, December 2007. Ridgway, James Matthew MD; Ahuja, Gurpreet MD; Guo, Shuguang PhD; Su, Jianping BS; Mahmood, Usama BS; Chen, Zhongping PhD; Wong, Brian MD, PhD Abstract: Objectives: Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high-resolution cross-sectional images in living tissue (8-20 [mu]m). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess the
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    19. Radiation dose could be cut for pulmonary embolism scans of pregnant patients

      Pulmonary embolism and other conditions may be detected in pregnant women using lower radiation doses than is currently standard, according to studies presented at the RSNA meeting on Monday. New techniques show promise, but obstacles such as small study populations and the lack of prospective trials must be overcome before a definitive protocol can be devised.
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    20. Tomophase to Exhibit First Cross-Sectional Images of Human Bronchus Using Proprietary OCT System

      【字体:大 中 小】 】   BURLINGTON, Mass., Oct. 17 /PRNewswire/ -- Tomophase Corporation announced today that it will display the first cross-sectional images of excised human bronchial tissue using their patented optical coherence tomography ("OCT") system at the CHEST meeting in Chicago, October 22nd through October 24th. The images were captured using the Tomophase OCT system as part of an ongoing research collaboration with Dr. Armin Ernst, Director of Interventional Pulmonology, at Be
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    21. Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography

      Matthew Brenner, Kelly Kreuter, David Mukai et al. Optical coherence tomography (OCT) is a micron scale high-resolution optical technology that can provide real-time in vivo images noninvasively. The ability to detect airway mucosal and submucosal injury rapidly will be valuable for a range of pulmonary applications including assessment of acute inh ... [J. Biomed. Opt. 12, 051701 (2007)] published Mon Oct 29, 2007.
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    22. Optical Coherence Tomography of Airway and Pleural Disorders

      Optical methods for obtaining images in airway passages for early detection of endobronchial lung and pleural cancer are needed. Optical coherence tomography (OCT) is a non-invasive or minimally invasive diagnostic technique that can provide information about tissue abnormalities. OCT can produce images of abnormalities both at and below the surface of the airways without damaging the tissue surface This technique uses a harmless device to emit infrared (not visible) light that can produce images of the specimen under investigation without causing damage or alterations
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