Pulmonology -Optical Coherence Tomography News

Articles in category: Pulmonology

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1. Rapid non-destructive volumetric tumor yield assessment in fresh lung core needle biopsies using polarization sensitive optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 5 2021 Pulmonology
  
  Adequate tumor yield in core-needle biopsy (CNB) specimens is essential in lung cancer for accurate histological diagnosis, molecular testing for therapeutic decision-making, and tumor biobanking for research. Insufficient tumor sampling in CNB is common, primarily due to inadvertent sampling of tumor-associated fibrosis or atelectatic lung, leading to repeat procedures and delayed diagnosis. Currently, there is no method for rapid, non-destructive intraprocedural assessment of CNBs. Polarization-sensitive optical coherence tomography (PS-OCT) is a high-resolution, volumetric imaging technique that has the potential to meet this clinical need. PS-OCT detects endogenous tissue properties, including birefringence from collagen, and degree of polarization uniformity (DOPU) indicative ...
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  Mentions: University of Michigan Massachusetts General Hospital Harvard University
2. Endobronchial Optical Coherence Tomography for the Diagnosis of Fibrotic ILD: A Light at the End of the Tunnel?
  
  Explore Home (thoracic) Sep 3 2021 Pulmonology
  
  No abstract provided.
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  Mentions: University of British Columbia
3. Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma
  
  Explore ScienceDirect Sep 1 2021 Pulmonology
  
  Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), including thickening of airway smooth muscle (ASM) as a key element of this alteration. 1 Patients with severe asthma may benefit from bronchial thermoplasty (BT), an endoscopic treatment that targets structural AR and induces ASM reduction. 2 Assessment of AR is critical to evaluate the impact of BT and might provide a tool for patient selection for BT. Polarization sensitive optical coherence tomography (PS-OCT) imaging has been proposed as a minimally invasive diagnostic method to assess ASM mass as an alternative to focal airway biopsies. Bronchoscopic standard optical coherence ...
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  Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam
4. Airway remodeling and bronchodilator responses in asthma assessed by endobronchial optical coherence tomography
  
  Explore Wiley Online Library Aug 28 2021 Pulmonology
  
  LETTER TO THE EDITOR
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5. University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement
  
  Explore Optical Coherence Tomography News Aug 18 2021 Pulmonology , Funding
  
  University of North Carolina Receives a 2021 NIH Grant for $797,092 for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement. The principal investigator is Amy Oldenburg. Below is a summary of the proposed work. Subglottic stenosis (SGS) is one of the most common life-threatening airway disorders in infants and children. Current treatment methods are based on airway endoscopy, which provides only qualitative information. Surgical treatment failures for the most severe grades of SGS range toward 50%, often due to post-operative airway collapse in new, unpredicted locations. Treatment ...
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  Mentions: National Institutes of Health University of North Carolina
6. Diagnostic Accuracy of Endobronchial Optical Coherence Tomography for the Microscopic Diagnosis of Usual Interstitial Pneumonia
  
  Explore Home (thoracic) Aug 11 2021 Pulmonology
  
  Rationale: Early, accurate diagnosis of interstitial lung disease (ILD) informs prognosis and therapy, especially in idiopathic pulmonary fibrosis (IPF). Current diagnostic methods are imperfect. HRCT resolution is limited while surgical lung biopsy (SLB) carries risks of morbidity/mortality. Endobronchial optical coherence tomography (EB-OCT) is a low-risk, bronchoscope-compatible modality that images large lung volumes in vivo with microscopic resolution, including subpleural lung, and has the potential to improve the diagnostic accuracy of bronchoscopy for ILD diagnosis. Objectives: We performed a prospective diagnostic accuracy study of EB-OCT in ILD patients with a low-confidence diagnosis undergoing SLB. Primary endpoints were EB-OCT sensitivity/specificity ...
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  Mentions: Massachusetts General Hospital Harvard University UCLA
7. MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Aug 10 2021 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2021 NIH Grant for $198,000 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
8. All-fiber probes for endoscopic optical coherence tomography of the large airways
  
  Explore OSA | OSA Publishing Jul 24 2021 Pulmonology , Probes
  
  Endoscopic optical coherence tomography of large airways poses unique challenges. A hybrid lens is described that consists of a section of coreless fiber and graded index fiber (GIF), followed by a ball lens section. This design produces low numerical aperture beams better suited for large airway imaging. The performance of this lens is compared against conventional GIF and ball lens designs. Forward- and side-viewing probes were modeled, fabricated, and tested. The impact of a sheath on the beam profile was also investigated. Probes with working distances larger than 10 mm and depth-of-focus exceeding 12 mm are demonstrated with the proposed ...
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  Mentions: University of North Carolina
9. Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction
  
  Explore SPIE Digital Library Jul 17 2021 Pulmonology
  
  Significance: Chronic lung allograft dysfunction (CLAD) is the leading cause of death in transplant patients who survive past the first year post-transplant. Current diagnosis is based on sustained decline in lung function; there is a need for tools that can identify CLAD onset. Aim: Endoscopic optical coherence tomography (OCT) can visualize structural changes in the small airways, which are of interest in CLAD progression. We aim to identify OCT features in the small airways of lung allografts that correlate with CLAD status. Approach: Imaging was conducted with an endoscopic rotary pullback OCT catheter during routine bronchoscopy procedures (n = 54), collecting ...
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  Mentions: University of British Columbia British Columbia Cancer Agency
10. University of Alabama Receives NIH Grant for The Role of Airway Mucus in Infection and Inflammation
  
  Explore Optical Coherence Tomography News Jun 8 2021 Pulmonology , Funding
  
  University of Alabama at Birmingham Receives a 2021 NIH Grant for $400,833 for The Role of Airway Mucus in Infection and Inflammation. The principal investigator is Susan Birket. Below is a summary of the proposed work. Abnormal mucociliary clearance (MCC) is a critical component of cystic fibrosis (CF) lung disease, and is postulated to contribute to the high incidence of chronic pulmonary infections in this patient population; in turn the presence of chronic infection is thought to worsen the MCC defect, creating a cycle of mucus obstruction, infection, and inflammation that is difficult to interrupt or reverse. However, the ...
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  Mentions: National Institutes of Health University of Alabama
11. Massachusetts General Hospital Receives NIH Grant for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy Response Assessment
  
  Explore Optical Coherence Tomography News Jun 8 2021 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2021 NIH Grant for $872,315 for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy Response Assessment. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal form of interstitial lung disease (ILD), affecting 100,000 per year in the US, with a 3-year survival rate of 50% and a large socio-economic healthcare burden. Early, accurate diagnosis is essential to determine treatment, which differs drastically between IPF and other ILDs. Initiating treatment as early as possible is a key strategy to prevent ...
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  Mentions: National Institutes of Health Massachusetts General Hospital
12. In vivo assessment of changes to canine airway smooth muscle volume following bronchial thermoplasty with OR-OCT
  
  Explore American Physiological Society Journal Apr 24 2021 Pulmonology
  
  The inability to assess and measure changes to the airway smooth muscle (ASM) in vivo is a major challenge to evaluating asthma and its clinical outcomes. Bronchial thermoplasty (BT) is a therapy for asthma that aims to reduce the severity of excessive bronchoconstriction by ablating ASM. While multiple long-term clinical studies of BT have produced encouraging results, the outcomes of BT treatment in practice have been variable, and questions remain regarding the selection of patients. Previously we have demonstrated an imaging platform called orientation-resolved optical coherence tomography that can assess ASM endoscopically using an imaging catheter compatible with bronchoscopy. In ...
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13. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway smooth muscle detection in bronchial thermoplasty treated asthma patients
  
  Explore CHEST Apr 1 2021 Pulmonology
  
  To the editor, 79 Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), 80 including thickening of airway smooth muscle (ASM) as a key element of this alteration (1). 81 Severe asthma patients may benefit from bronchial thermoplasty (BT), an endoscopic 82 treatment that targets structural AR and induces ASM reduction (2). Assessment of AR is 83 critical to evaluate the impact of BT and might provide a tool for BT patient selection. 84 Polarization sensitive optical coherence tomography (PS-OCT) has been proposed as a 85 minimally invasive diagnostic method to assess ASM mass as alternative to focal ...
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  Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam
14. Massachusetts General Hospital Receives NIH Grant for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy
  
  Explore Optical Coherence Tomography News Mar 12 2021 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2021 NIH Grant for $848,987 for In Vivo Endobronchial OCT for IPF Diagnosis and Therapy. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal form of interstitial lung disease (ILD), affecting 100,000 per year in the US, with a 3-year survival rate of 50% and a large socio-economic healthcare burden. Early, accurate diagnosis is essential to determine treatment, which differs drastically between IPF and other ILDs. Initiating treatment as early as possible is a key strategy to prevent irreversible loss ...
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  Mentions: National Institutes of Health Massachusetts General Hospital
15. Optical coherence tomography angiography in miliary tuberculosis
  
  Explore Oman Journal of Ophthalmology Feb 8 2021 Ophthalmology , Pulmonology
  
  A 14-year-old female was admitted with a history of high-grade fever. On admission, she underwent a comprehensive clinical, laboratory, and radiological evaluation. A contrast-enhanced computed tomography (CT) scan of the chest revealed multiple, tiny, nodular opacities in a ground-glass pattern bilaterally. Sputum studies were positive for Mycobacterium tuberculosis . Dilated fundus examination revealed multiple, yellow-white, deep choroidal lesions consistent with choroidal tubercles. She underwent optical coherence tomography angiography (OCTA) in both eyes, which revealed normal superficial and deep retinal plexuses but multiple areas of flow void in the choriocapillaris. The optical coherence tomography (OCT) sections showed hyperreflective areas in the choriocapillaris ...
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16. Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19
  
  Explore Home - ClinicalTrials.gov Jan 20 2021 Pulmonology , Clinical Trials
  
  The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure as measured by OCT. Correlating endobronchial assessment with multiple breath nitrogen washout and impulse oscillometry will allow the characterisation of the relationship between small airway structural findings and these validated investigations. A small volume lung wash, endobronchial brushings and the collection of a limited number of endobronchial cryobiopsy samples will be performed to better understand the endobronchial environment of the small airways through inflammatory studies. Following the completion ...
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  Mentions: Imperial College London
17. Application of Polarization Sensitive-Optical Coherence Tomography to the Assessment of Phase Retardation in Subpleural Cancer in Rabbits
  
  Explore Home - Springer Jan 9 2021 Pulmonology
  
  Background: Polarization sensitive-optical coherence tomography (PS-OCT) provides the unique advantage of being able to measure the optical characteristics of tissues by using polarized light. Although the well-organized fibers of healthy muscle can change the polarization states of passing light, damaged tissue has different behaviors. There are studies on optical imaging methods applied to the respiratory organs; however, they are restricted to structural imaging. In particular, the intercostal muscle situated under the pleura is very challenging to visualize due to the difficulty of access. Method: In this study, PS-OCT was used to identify subpleural cancer in male New Zealand white rabbits ...
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18. Massachusetts General Hospital Receives NIH Grant for Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
  
  Explore Optical Coherence Tomography News Jan 5 2021 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2021 NIH Grant for $662,413 for Early Detection and Diagnosis of Lung Cancer with Endomicroscopy. The principal investigator is Melissa Suter. Below is a summary of the proposed work. Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread offering patients little hope for cure (average 5-year survival rate < 15%). The U.S. Preventive Services Task Force recommends individuals at high risk of developing lung cancer undergo yearly screening with low dose computed tomography (LDCT). Screening is highly ...
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  Mentions: National Institutes of Health Massachusetts General Hospital
19. Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise
  
  Explore The Physiological Society Dec 30 2020 Pulmonology
  
  Airway luminal area (A i ) influences respiratory mechanics during dynamic exercise; however, previous studies have investigated the relationship between airway anatomy and physiological function in different groups of individuals. The purpose of this study was to determine the effect of A i on respiratory mechanics by making in vivo measures of airway dimensions and work of breathing (Wb) in the same individuals. Healthy participants (3F/2M; 23-45 years) completed a cycle exercise test to exhaustion. During exercise, Wb was assessed using an esophageal balloon catheter, while simultaneously assessing minute ventilation ( ˙ V E ). On a separate day, subjects underwent a bronchoscopy ...
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  Mentions: University of British Columbia
20. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging
  
  Explore European Respiratory Journal Nov 3 2020 Pulmonology
  
  Introduction: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma that reduces airway smooth muscle (ASM) by radiofrequent energy. No diagnostic method is currently available to assess ASM, other than invasive, focal airway biopsies. Bronchoscopic standard optical coherence tomography (OCT) generates high resolution images of the airways. Polarization sensitive OCT (PS-OCT) provides tissue-specific contrast that might enable ASM detection and quantification. Aim: Use novel PS-OCT to detect ASM and determine changes in ASM before and after BT in severe asthma. Methods: Bronchoscopic PS-OCT was performed from distal to proximal airways in a severe asthma patient before and after BT ...
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21. Massachusetts General Hospital Receives NIH Grant for Low Risk In Vivo Diagnosis of IPF with Optical Imaging
  
  Explore Optical Coherence Tomography News Aug 4 2020 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2020 NIH Grant for $179,280 for Low Risk In Vivo Diagnosis of IPF with Optical Imaging. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, ultimately fatal form of idiopathic interstitial pneumonitis (IIP), with a 3 year survival rate of 0%. Diagnostic certainty of IPF is critical to patient management and therapeutic decision-making. Two new FDA-approved therapies, pirfenidone and nintedanib, have been shown to slow disease progression in IPF and brought new hope to IPF patients. Due to their high costs, side ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
22. Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Aug 4 2020 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2020 NIH Grant for $187,546 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...
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  Mentions: National Institutes of Health Massachusetts General Hospital Harvard University
23. Massachusetts General Hospital Receives NIH Grant for Functional Imaging
  
  Explore Optical Coherence Tomography News Jul 22 2020 Pulmonology , Funding
  
  Massachusetts General Hospital Receives a 2020 NIH Grant for $338,401 for Functional Imaging. The principal investigator is Benjamin Vakoc. Below is a summary of the proposed work. TRD 2 TRD project 2 will develop novel optical coherence tomography (OCT) technologies to address unmet needs in the functional imaging of tissue. Specific Aim #1 addresses the need for high-speed and high- resolution angiographic imaging systems for preclinical research. A new high-speed optical architecture for high-resolution optical coherence microscopy (OCM) will be constructed that is 100 times faster than existing OCM instrumentation. These improvements in speed will be leveraged to expand ...
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  Mentions: National Institutes of Health Massachusetts General Hospital
24. CLE and OCT in Acute Respiratory Insufficiency
  
  Explore Home - ClinicalTrials.gov Jul 21 2020 Pulmonology , Clinical Trials
  
  Acute respiratory distress syndrome is a severe complication of critical illness. The diagnosis of ARDS is difficult, and it could be important to differentiate ARDS from other causes of acute respiratory failure. Innovative probe-based imaging techniques such as 'Confocal Laser Endomicroscopy' (CLE) and Optical Coherence Tomography (OCT) are high resolution optical techniques that, combined with conventional bronchoscopy, have been found to provide non-invasive, real-time near-histology information about the alveolar compartment in non ventilated non-critically ill patients.
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  Mentions: Academic Medical Center at the University of Amsterdam
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