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OCT Companies in the News
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(14 articles) University of Western Australia
(10 articles) Dresden University of Technology
(10 articles) Sir Charles Gairdner Hospital
(8 articles) British Columbia Cancer Agency
(5 articles) University of British Columbia
(3 articles) Beth Israel Deaconess Medical Center
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Advances in Diagnostic Bronchoscopy
Explore Article ajrccm.atsjournals.org (Aug 28 2010)
Diagnostic bronchoscopy has undergone two major paradigm shifts in the last 40 years. First, the advent of flexible bronchoscopy gave chest physicians improved access to the tracheobronchial tree with a rapid learning curve and greater patient comfort compared with rigid bronchoscopy. The second paradigm shift has evolved over the last 5 years with the proliferation of new technologies that have significantly enhanced the diagnostic capabilities of flexible bronchoscopy compared with traditional methods. At the forefront of these new technologies is endobronchial ultrasound. In its various forms, endobronchial ultrasound has improved diagnostic yield for pulmonary masses, nodules, intrathoracic adenopathy, and disease ...
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Changes and Current State of Diagnosis of Lung Cancer After Development of the Flexible Bronchofiberscope
Explore Article Oxford Journals (Aug 24 2010)
The flexible bronchofiberscope developed by Ikeda et al. has brought about revolutionary changes in the diagnosis and treatment of lung cancer. Advances in this device are continuing to emerge and lesions even smaller than those visible to the naked eye can now be visualized. In addition, the use of ultrasound now enables diagnosis of extramural bronchial lesions. Bronchoscopy is also used for the treatment of early hilar lung cancer, and in patients with airway stenosis due to advanced cancer, laser therapy, brachytherapy, and stenting can be performed. The bronchofiberscope is also very useful for tissue sampling from the lung periphery. ...
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Photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways more than 1.0 cm in diameter.
Explore Article Journal of Clinical Oncology (Jun 15 2010)
Background: Photodynamic therapy (PDT) is recommended as a treatment option for centrally located early lung cancers (CLELCs), meaning roentgenographically occult squamous cell carcinomas that are located no more distally than segmental bronchi and, histologically, are either carcinoma in situ or carcinoma associated with only limited invasion. Since CLELC patients who are heavy smokers are at fairly high risk of developing a second primary lung cancer, they require treatment that will preserve their cardiopulmonary function. Most centrally located early lung cancers (CLELCs) less than 1.0 cm in diameter do not invade beyond the bronchial cartilage, and photodynamic therapy (PDT) with Photofrin ...
Comment on Article Mentions: Tokyo Medical University
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Virtual four-dimensional imaging of lung parenchyma by optical coherence tomography in mice
Explore Article SPIE Digital Library (May 20 2010)
In this feasibility study, we present a method for virtual 4-D imaging of healthy and injured subpleural lung tissue in the ventilated mouse. We use triggered swept source optical coherence tomography (OCT) with an A-scan frequency of 20 kHz to image murine subpleural alveoli during the inspiratory phase. The data acquisition is gated to the ventilation pressure to take single B-scans in each respiration cycle for different pressure levels. The acquired B-scans are combined off-line into one volume scan for each pressure level. The air fraction in healthy lungs and injured lungs is measured using 2-D OCT en-face images. Upon ...
Comment on Article Mentions: Sven Meissner Dresden University of Technology Edmund Koch
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Combining optical coherence tomography with fluorescence microscopy: a closer look into tissue
Explore Article SPIE Digital Library (May 18 2010)
Optical coherence tomography (OCT) is a technique, capable of high resolution and non-invasive 3D imaging in vivo by detection of backscattered light from cellular and sub cellular structures. Due to visualization of micrometer sized tissue constituents and high penetration depths of up to 2 mm, it is already well established in medical fields like ophthalmology and dermatology. Laser scanning confocal microscopy (LSCM), on the contrary, gives further information on structural tissue components stained with suitable dyes. In combination, these two methods yield three dimensional and high resolution data providing geometrical and structural details of tissue. In this study, we present ...
Comment on Article Mentions: Sven Meissner Edmund Koch Dresden University of Technology
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Optical Coherence Tomography as an Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer: A Pilot Study
Explore Article chestjournal.chestpubs.org (May 16 2010)
Background: Lung cancer is the leading cause of cancer-related deaths in the United States and the second most common type of cancer in both men and women. Optical coherence tomography (OCT) can generate high resolution cross-sectional images of complex, living tissues in real time. The objectives of this study were to determine the feasibility of using OCT during flexible bronchoscopy, and to preliminarily assess the ability of OCT to distinguish an endobronchial malignancy from normal endobronchial mucosa. Methods: A NirisTM OCT probe was introduced into the airways of patients with an endobronchial mass during flexible bronchoscopy. An investigational device exemption ...
Comment on Article Mentions: Imalux Imalux Niris FDA
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Competing Technologies: Ultrasound, Navigational Bronchoscopy, Optical Coherence Tomography, etc. – Who Will Win Out?
Explore Article karger.com (May 1 2010)
Bronchoscopy in the new millennium spells an exciting time for the pulmonologist, which likens to Alice peering through the looking glass into a wonderland of miniaturized probes, superior optics and technology that are advancing at a maddening pace. Whilst scientists continue to push the envelope using nanotechnology where nanoparticles each measuring one billionth of a meter may facilitate further miniaturization of probes to allow imaging at the cellular or molecular level as well as for targeted drug or gene delivery in the near future, it is opportune to evaluate the strengths and weaknesses of available technologies in thoracic imaging, for ...
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Bronchoscopic Advances: On the Way to the Cells
Explore Article karger.com (May 1 2010)
In the past 15 years, new endoscopic methods have been developed in order to improve the detection of early bronchial cancers, with autofluorescence bronchoscopy being the leading technique. However, autofluorescence bronchoscopy is hampered by the low specificity of the fluorescence defect which ranges from 25 to 50%, and its limitation to the proximal bronchial tree from which arise only half of the lung cancers that are currently diagnosed. To overcome these limitations, other techniques emerge including video/autofluorescence bronchoscopy, narrow band imaging, optical coherence tomography, and ‘endomicroscopy’ using confocal fluorescent laser microscopy. These emerging techniques provide new insight into bronchology, extending ...
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Tomophase Receives Seventh Patent: Delivering Light via Optical Waveguide and Multiview Optical Probe Head
Explore Article Optical Coherence Tomography News (Apr 27 2010)
BURLINGTON, Mass.--(BUSINESS WIRE)--Tomophase Corporation, a leading developer of non-invasive optical coherence tomography (OCT) tissue imaging devices, announced today that it has received notification of the issuance of its seventh patent: Delivering Light via Optical Waveguide and Multi-view Opt
Comment on Article Mentions: Peter Norris Tomophase Corporation FDA
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Delivering light via optical waveguide and multi-view optical probe head
Explore Article uspto.gov (Apr 27 2010)
Techniques, apparatus and systems that use an optical probe head to deliver light to a target and to collect light from the target for imaging, monitoring, medical diagnostics and medical treatment applications.
Comment on Article Mentions: Tomophase Corporation
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Outcome of Photodynamic Therapy Using NPe6 for Bronchogenic Carcinomas in Central Airways >1.0 cm in Diameter
Explore Article Clinical Cancer Research (Mar 29 2010)
Purpose: Most centrally located early lung cancers (CLELC) <1.0 cm in diameter do not invade beyond the bronchial cartilage, and photodynamic therapy (PDT) with Photofrin is currently recommended as a treatment option for such lesions. NPe6 is a second-generation photosensitizer, and because it has a longer absorption band (664 nm) than Photofrin (630 nm), we hypothesized that NPe6-PDT would exert a strong antitumor effect against cancer lesions >1.0 cm in diameter, which are assumed to involve extracartilaginous invasion and to be unsuitable for treatment with Photofrin-PDT. Experimental Design: Between June 2004 and December 2008, 75 patients (91 lesions) with CLELC ...
Comment on Article Mentions: LightLab Imaging Tokyo Medical University
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Tomophase Corporation Names Ralph S. Johnston President and Chief Operating Officer
Explore Article Healthcare Sales & Marketing Network (Mar 22 2010)
BURLINGTON, Mass.--(HSMN NewsFeed)--Tomophase Corporation, a leading developer of non-invasive optical coherence tomography (OCT) tissue imaging devices, announced today that Ralph S. Johnston has been appointed President and Chief Operating Officer of the company. The announcement was made by Dr. Peter Norris, CEO, Co-Founder and Chairman of the Board. Mr. Johnston brings over 25 years of experience in medical devices and pharmaceuticals to the business. He has held senior management positions in business development, strategic marketing and sales with venture-backed start-up enterprises and Fortune 500 companies Pfizer and Corning Medical.
Comment on Article Mentions: Peter Norris Tomophase Corporation
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Early Diagnosis of Lung Cancer
Explore Article Clinics In Chest Medicine (Feb 23 2010)
Early detection and surgical resection is essential for the treatment of lung cancer. Although the introduction of low-dose spiral computed tomography (CT) is considered to be one of the most promising clinical research developments, CT screening is used for detecting small peripheral lesions. Tumors arising in the central airways require other techniques for early detection. Centrally arising squamous cell carcinoma of the airway, especially in heavy smokers, is thought to develop through multiple stages from squamous metaplasia to dysplasia, followed by carcinoma in situ (CIS), progressing to invasive cancer. It would be ideal to be able to detect and treat ...
Comment on Article Mentions: University of Toronto
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Three-dimensional Fourier domain optical coherence tomography in vivo imaging of alveolar tissue in the intact thorax using the parietal pleura as a window
Explore Article SPIE Digital Library (Feb 9 2010)
In vivo determination of 3-D and dynamic geometries of alveolar structures with adequate resolution is essential for developing numerical models of the lung. A thorax window is prepared in anesthetized rabbits by removal of muscle tissue between the third and fourth rib without harming the parietal pleura. The transparent parietal pleura allows contact-free imaging by intravital microscopy IVM and 3-D optical coherence tomography 3-D OCT. We demonstrate that dislocation of the lung surface is small enough to observe identical regions in the expiratory and inspiratory plateau phase, and that OCT in this animal model is suitable for generating 3-D geometry ...
Comment on Article Mentions: Sven Meissner Dresden University of Technology Edmund Koch
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Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography
Explore Article Respiratory Research (Jan 23 2010)
Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway narrowing responses across a portion of the porcine bronchial tree was determined in vitro. The portion comprised contiguous airways spanning bronchial generations (#3-11), including the associated side branches. We used a ...
Comment on Article Mentions: Julian J. Armstrong David D. Sampson University of Western Australia
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