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(14 articles) University of Western Australia
(10 articles) Sir Charles Gairdner Hospital
(8 articles) Dresden University of Technology
(8 articles) British Columbia Cancer Agency
(5 articles) University of British Columbia
(3 articles) Beth Israel Deaconess Medical Center
(2 articles) Food and Drug Administration
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Early Diagnosis of Lung Cancer
Explore Article Clinics In Chest Medicine (Feb 23 2010) Bronchoscopy
Early detection and surgical resection is essential for the treatment of lung cancer. Although the introduction of low-dose spiral computed tomography (CT) is considered to be one of the most promising clinical research developments, CT screening is used for detecting small peripheral lesions. Tumors arising in the central airways require other techniques for early detection. Centrally arising squamous cell carcinoma of the airway, especially in heavy smokers, is thought to develop through multiple stages from squamous metaplasia to dysplasia, followed by carcinoma in situ (CIS), progressing to invasive cancer. It would be ideal to be able to detect and treat ...
Comment on Article Mentions: University of Toronto
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Three-dimensional Fourier domain optical coherence tomography in vivo imaging of alveolar tissue in the intact thorax using the parietal pleura as a window
Explore Article SPIE Digital Library (Feb 9 2010) Bronchoscopy
In vivo determination of 3-D and dynamic geometries of alveolar structures with adequate resolution is essential for developing numerical models of the lung. A thorax window is prepared in anesthetized rabbits by removal of muscle tissue between the third and fourth rib without harming the parietal pleura. The transparent parietal pleura allows contact-free imaging by intravital microscopy IVM and 3-D optical coherence tomography 3-D OCT. We demonstrate that dislocation of the lung surface is small enough to observe identical regions in the expiratory and inspiratory plateau phase, and that OCT in this animal model is suitable for generating 3-D geometry ...
Comment on Article Mentions: Sven Meissner Dresden University of Technology Edmund Koch
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Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography
Explore Article Respiratory Research (Jan 23 2010) Bronchoscopy
Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway narrowing responses across a portion of the porcine bronchial tree was determined in vitro. The portion comprised contiguous airways spanning bronchial generations (#3-11), including the associated side branches. We used a ...
Comment on Article Mentions: Julian J. Armstrong David D. Sampson University of Western Australia
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Optical coherence tomography imaging of preneoplastic lung lesion
Explore Article Cancer Prevention Research (Jan 8 2010) Bronchoscopy , Oncology
Although autofluorescence bronchoscopy improves the detection rate of high grade dysplasia and carcinoma in-situ compares to white-light examination, the natural history of preneoplastic bronchial lesions is still poorly understood because the biopsy procedure for histological confirmation can mechanically remove these small lesions. The lack of accurate information regarding the spontaneous progression and regression rates of preneoplastic lesions make if difficult to assess the effect of chemoprevention agents. It is therefore important to develop non-biopsy methods that can characterize preneoplastic lesions in the bronchial epithelium. Optical coherence tomography (OCT) is an optical imaging method that can visualize cellular and extra-cellular structures ...Comment on Article Mentions: University of British Columbia Victor X. D. Yang Ryerson University
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In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance
Explore Article SPIE Digital Library (Dec 22 2009) Bronchoscopy
The purpose of this study was to develop a dynamic tunable focal distance graded-refractive-index lens rod-based high-speed 3-D swept-source (SS) optical coherence tomography (OCT) endoscopic system and demonstrate real-time in vivo, high-resolution (10-µm) imaging of pleural-based malignancies in an animal model. The GRIN lens-based 3-D SS OCT system, which images at 39 fps with 512 A-lines per frame, was able to capture images of and detect abnormalities during thoracoscopy in the thoracic cavity, including the pleura, chest wall, pericardium, and the lungs. The abnormalities were confirmed by histological evaluation and compared to OCT findings. The dynamic tunable focal distance range ...Comment on Article Mentions: Zhongping Chen UC Irvine
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Improved three-dimensional Fourier domain optical coherence tomography by index matching in alveolar structures
Explore Article SPIE Digital Library (Dec 21 2009) Bronchoscopy
Three-dimensional Fourier domain optical coherence tomography (3-D FDOCT) is used to demonstrate that perfusion fixation with a mixture of glutaraldehyde and paraformaldehyde does not alter the geometry of subpleural lung parenchyma in isolated and perfused rabbit lungs. This is confirmed by simultaneous imaging of lung parenchyma with intravital microscopy. To eliminate the diffraction index interfaces between alveolar pockets and walls, we fill the fixed lungs with ethanol by perfusing with gradually increasing concentrations. This bottom-up filling process leaves no remaining air bubbles in the alveolar structures, thus drastically improving the resolution and penetration depth of 3-D FDOCT imaging. We observe ...Comment on Article Mentions: Dresden University of Technology Edmund Koch Sven Meissner
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Optical Coherence Tomography: An Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer
Explore Article Home - ClinicalTrials.gov (Dec 11 2009) Bronchoscopy , Oncology , Clinical Trials
Optical coherence tomography will be a feasible adjunct to flexible bronchoscopy, and provide images with good sensitivity and specificity to determine the presence of endobronchial malignancies. OCT could become a powerful tool in diagnostic pulmonary medicine, not only in the early recognition of lung cancer, but also in the evaluation and monitoring of microstructures in the lower respiratory tract that are affected by other inflammatory or invasive disease processes. Initially, OCT could be used to guide the location of biopsies which would likely provide increased specificity to traditional bronchoscopy. However, if the sensitivity and specificity of OCT images are comparable ... -
In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography
Explore Article SPIE Digital Library (Dec 7 2009) Bronchoscopy
We report on the feasibility of rapid, high-resolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based on ...
Comment on Article Mentions: Zhongping Chen UC Irvine Matthew Brenner
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Gaining a better picture of lung disease
Explore Article Western News (Nov 20 2009) Bronchoscopy , Funding
Chronic obstructive pulmonary disease (COPD), a respiratory disease commonly known as chronic bronchitis or emphysema, is the fourth leading cause of death worldwide, but a University of Western Ontario researcher is providing new insight into the disease. With 600 million people living with COPD, researchers have yet to find any real treatment or cure. However, Grace Parraga of Robarts Research Institute is using various imaging techniques to learn more about the diease. The World Health Organization officially recognized World COPD Day on Wednesday. Parraga is a scientist in the Imaging Research Laboratories at Robarts and recently recruited to the Departments ...Comment on Article Mentions: World Health Organization Grace Parraga
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Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis
Explore Article www3.interscience.wiley.com (Nov 18 2009) Bronchoscopy
Objectives/Hypothesis. Recurrent respiratory papillomatosis (RRP) of the central airways requires removal to potentially reduce recurrence and risk for malignant transformation. Analogous to the principles of treatment for early lung cancer, a precise determination of the extent of cartilage invasion could help guide therapeutic decisions and monitor response to treatment. The purpose of this study was to determine whether a bronchoscopy platform comprised of white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) could identify layered microstructure of RRP and underlying cartilage. Study Design. Case study. Methods. A bronchoscopy platform consisting of commercially available WLB, EBUS using a ...Comment on Article Mentions: UC Irvine University of Ulsan Matthew Brenner
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Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function
Explore Article Journal of Applied Physiology (Nov 13 2009) Bronchoscopy
Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter with a range of imaging modalities. We describe a new optical technique, anatomical optical coherence tomography (aOCT), which allows changes at the luminal surface (airway caliber) to be temporally related ...
Comment on Article Mentions: Julian J. Armstrong David D. Sampson University of Western Australia
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Simultaneous three-dimensional optical coherence tomography and intravital microscopy for imaging subpleural pulmonary alveoli in isolated rabbit lungs
Explore Article SPIE Digital Library (Oct 12 2009) Bronchoscopy
There is a growing interest in analyzing lung mechanics at the level of the alveoli in order to understand stress-related pathogenesis and possibly avoid ventilator associated lung injury. Emerging quantitative models to simulate fluid mechanics and the associated stresses and strains on delicate alveolar walls require realistic quantitative input on alveolar geometry and its dynamics during ventilation. Here, three-dimensional optical coherence tomography (OCT) and conventional intravital microscopy are joined in one setup to investigate the geometric changes of subpleural alveoli during stepwise pressure increase and release in an isolated and perfused rabbit lung model. We describe good qualitative agreement and ...Comment on Article Mentions: Sven Meissner Dresden University of Technology Edmund Koch
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Comparison of two in vivo microscopy techniques to visualize alveolar mechanics
Explore Article SpringerLink Home (Sep 19 2009) Bronchoscopy , Microscopy
Objective In conventional in vivo microscopy, a three dimensional illustration of tissue is lacking. Concerning the microscopic analysis of the pulmonary alveolar network, surgical preparation of the thorax and fixation of the lung is required to place the microscope’s objective. These effects may have influence on the mechanical behaviour of alveoli. Relatively new methods exist for in vivo microscopy being less invasive and enabling an observation without fixation of the lung. The aim of this study was to compare a fibered confocal laser scanning microscopy (FCLSM) with optical coherence tomography (OCT) in a mouse and a rabbit model. Moreover, FCLSM ...Comment on Article Mentions: Dresden University of Technology Edmund Koch Sven Meissner
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Developmental Aspects of the Upper Airway
Explore Article pats.atsjournals.org (Sep 10 2009) Bronchoscopy , Otolaryngology
The upper airway serves three important functions: respiration, swallowing, and speech. During development it undergoes significant structural and functional changes that affect its size, shape, and mechanical properties. Abnormalities of the upper airway require prompt attention, because these often alter ventilatory patterns and gas exchange, particularly during sleep when upper airway motor tone and ventilatory drive are diminished. Recognizing the relationship of early life events to lung health and disease, the National Heart, Lung, and Blood Institute (NHLBI), with cofunding from the Office of Rare Diseases (ORD), convened a workshop of extramural experts, from many disciplines. The objective of the ...Comment on Article Mentions: University of Wisconsin University of Maryland Johns Hopkins University
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Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography
Explore Article SPIE Digital Library (Aug 25 2009) Bronchoscopy
Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technology capable of delivering real-time, near-histologic images of tissues. Mustard gas is a vesicant-blistering agent that can cause severe and lethal damage to airway and lungs. The ability to detect and assess airway injury in the clinical setting of mustard exposure is currently limited. The purpose of this study is to assess the ability to detect and monitor progression of half-mustard [2-chloroethylethylsulfide (CEES)] airway injuries with OCT techniques. A ventilated rabbit mustard exposure airway injury model is developed. A flexible fiber optic OCT probe is introduced into the distal trachea to ...Comment on Article Mentions: Zhongping Chen Shuguang Guo UC Irvine
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