1. Articles in category: Ophthalmology

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    1. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography

      Axonal loss is thought to be the predominant cause of disability in progressive multiple sclerosis (MS). The retinal nerve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography (OCT), giving a measure of axonal loss. OCT measures of the RNFL thickness (RNFLT) and macular volume were studied in 23 patients with primary progressive multiple sclerosis (primary progressive MS) (13 male; 10 female; mean age 52 years; median EDSS 6.0; mean disease duration 11 years), and 27 patients with secondary progressive multiple sclerosis (secondary progressive MS) (8 ...
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    2. En Face Optical Coherence Tomography of the Posterior Pole in High Myopia

      Purpose To evaluate a large series of patients affected by high myopia using multiplanar imaging provided by en face optical coherence tomography (OCT). Design Observational cross-sectional study. Methods En face OCT longitudinal cross-sectional B scans and coronal C scans were obtained in 200 eyes of 100 patients with myopia greater than –6 diopters and evidence of posterior staphyloma at fundus examination and at ultrasound B-scan evaluation. Results A macular hole was present in three eyes (1.5%). We detected posterior retinal detachment in 37 cases (18.5%). In 15 eyes (7.5%) detachment was associated with a macular hole. In ...
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    3. Dr. Zhongping Chen Elected Fellow of the Optical Society of America

      Dr. Zhongping Chen Elected Fellow of the Optical Society of America
      Professor Zhongping Chen Elected as Fellow of the Optical Society of America Zhongping Chen, professor of biomedical engineering and electrical engineering and computer science, was recently named a new Fellow of the Optical Society of America. This prestigious honor is given to only ten percent of the OSA membership, and is dedicated to members who have served with distinction in the advancement of optics. Chen was honored specifically for his pioneering contributions to the development of func
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    4. Repeatability and Reproducibility of Pachymetric Mapping with Visante Anterior Segment Optical Coherence Tomography

      purpose. To determine the repeatability and reproducibility of central and peripheral corneal pachymetry mapping with anterior segment–optical coherence tomography (AS-OCT). methods. An observational cross-sectional study involving two groups: 27 healthy eyes and 20 eyes with keratoconus. Each subject underwent scanning sessions with AS-OCT to determine intraobserver repeatability, interobserver reproducibility, and additionally for healthy eyes, intersession reproducibility for different regions of the cornea up to a 10-mm diameter. Main outcome measures were reproducibility and repeatability coefficients, intraclass correlation coefficients, and coefficients of variation of the average central (0–2 mm), pericentral (2–5 mm), transitional (5–7 mm), and peripheral ...
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    5. [Retina] The Effects of Intravitreous Bevacizumab on Retinal Neovascular Membrane and Normal Capillaries in Rabbits

      purpose. To evaluate the effects of intravitreous bevacizumab in a rabbit retinal neovascularization model. methods. Twenty-four rabbits were divided into five groups. Group A included four rabbits; all other groups included five rabbits each. Group A received intravitreous VEGF only, and group E received intravitreous bevacizumab only. In groups B, C, and D, bevacizumab was injected at the same time, at day 2 and at week 1 after VEGF injection, respectively. Follow-up evaluations continued for 3 weeks and included color fundus photography, fluorescein angiography (FA), and optical coherence tomography (OCT). Enucleated eyes were processed for hematoxylin and eosin (H&E ...
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    6. The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis

      purpose. To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness, measured by optical coherence tomography (OCT), in patients with multiple sclerosis (MS). methods. SAP and RNFL thickness were measured in patients with MS in 28 eyes with the last optic neuritis (ON) ≥6 months prior (ON group) and 33 eyes without ON history (non-ON group). Abnormal overall or quadrant RNFL thickness was defined by measured values below 5% of the norm. A whole visual field or a sector of the field was classified as abnormal by using cluster criteria ...
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    7. OPKO Health Acquires OTI for $10M

      On November 28, 2007, OPKO Health, Inc., ("the Company") completed the previously announced acquisition of the remaining shares of Ophthalmic Technologies, Inc. (OTI), a privately owned Canadian company providing innovative ocular imaging systems to eye care professionals worldwide. Pursuant to a Share Purchase Agreement and an Exchange and Support Agreement with OTI and its shareholders, the Company exercised an option (the "Option") to acquire the remaining shares of OTI and issued shares exchangeable into an aggregate of approximately 2,817,000 shares of OPKO Common Stock based upon a purchase price of $10,000,000 and a value of $3 ...
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      Mentions: Optos
    8. OPKO Health Completes Acquisition of Ophthalmic Technologies, Inc.

      MIAMI, Nov. 29 /PRNewswire-FirstCall/ -- OPKO Health Inc. (AMEX: OPK)today announced that it has completed the previously announced acquisition ofOphthalmic Technologies, Inc. (OTI), a privately owned Canadian companyproviding innovative ocular imaging systems to eye care professionalsworldwide. "OPKO has already made excellent progress in integrating OTI as we haveactively worked together over the past months to prepare for the recent marketintroduction of our breakthrough Spectral SLO OCT system," said Rishard Weitz,President of OTI. "Our team believes there is the potential for powerfulsynergies between OPKO's therapeutics pipeline and the diagnostic systems anddevices used by eye care professionals, and we expect ...
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      Mentions: Optos
    9. OPKO Health Completes Acquisition of Ophthalmic Technologies, Inc.

      MIAMI, Nov 29, 2007 /PRNewswire-FirstCall via COMTEX News Network/ -- OPKO Health Inc. (AMEX: OPK) today announced that it has completed the previously announced acquisition of Ophthalmic Technologies, Inc. (OTI), a privately owned Canadian company providing innovative ocular imaging systems to eye care professionals worldwide. "OPKO has already made excellent progress in integrating OTI as we have actively worked together over the past months to prepare for the recent market introduction of our
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      Mentions: Optos
    10. Foveal Photoreceptor Layer in Eyes with Persistent Cystoid Macular Edema Associated with Branch Retinal Vein Occlusion

      A prototype high-speed OCT system was fabricated for patient examinations based on Fourier domain OCT. The system had a sensitivity of 98 dB, a tissue axial resolution of 4.3 μm, and an acquisition rate of approximately 18 700 axial scans per second. Three-dimensional imaging was performed based on a raster-scan protocol. Anatomic features of CSC distinguished by 3-D OCT. A line corresponding to backreflection from the external limiting membrane (ELM) was visible in images from eyes with all sta
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    11. Diabetic Retinopathy: Reports outline diabetic retinopathy research from University of Florence, Department of Ophthalmology

      New research, 'Optical coherence tomography versus stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema: a systematic review,' is the subject of a report. In this recent study, researchers in Florence, Italy conducted a study "To review systematically the sensitivity and specificity of optical coherence tomography (OCT) for diagnosing macular...
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    12. Foveal Dysplasia Evident By Optical Coherence Tomography In Patients With A History Of Retinopathy Of Prematurity.

      For patients with a history of retinopathy of prematurity, optical coherence tomography demonstrates a shallow or absent foveal depression, an anatomical finding that may reflect interrupted fetal macular development and may still be associated with excellent visual acuity.Page: 1221DOI: 10.1097/IAE.0b013e318068de2eAuthors: RECCHIA, FRANCO M. MD; RECCHIA, CYNTHIA C. MD
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    13. Optical Coherence Tomography Characteristics Of Group 2A Idiopathic Parafoveal Telangiectasis.

      Purpose: To describe the optical coherence tomography (OCT) characteristics of patients with group 2A idiopathic parafoveal telangiectasis (IPFT) and to correlate them with biomicroscopic and fluorescein angiographic (FA) findings based on Gass and Blodi staging classification for group 2A IPFT. Methods: Fifty-two eyes of 26 consecutive patients with IPFT underwent biomicroscopic fundus examination, color fundus photography, FA, and OCT. Main outcome measures were OCT characteristics and their correlation with biomicroscopy and FA. Results: The most common OCT findings that help differentiate between stages in group 2A IPFT are 1) highly reflective dots in the inner retina that correspond with microvessels ...

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    14. Intravitreal Bevacizumab (Avastin) Injection As Primary Treatment Of Inflammatory Choroidal Neovascularization.

      In this small case series of eyes with limited follow-up, intravitreal bevacizumab injection for treatment of inflammatory choroidal neovascularization (CNV) was found to be safe and was associated with favorable visual outcomes for both subfoveal and juxtafoveal or extrafoveal inflammatory CNV.Page: 1180DOI: 10.1097/IAE.0b013e31815e9834Authors: ADAN, ALFREDO MD, PhD * +; MATEO, CARLOS MD +; NAVARRO, RAFAEL MD +; BITRIAN, ELENA MD *; CASAROLI-MARANO, RICARDO P. MD, PhD *
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    15. Advances in spectral domain 3-D high-resolution OCT

      Spectral domain optical coherence tomography (SD-OCT), the latest generation of the technology, is a breakthrough because it has dramatically cut the time required to obtain images by eliminating the moving mirror that was a component of standard OCT, according to Cynthia Toth, MD. In addition to being 50 times faster than conventional OCT, SD-OCT has improved resolution because of improved processing. Another benefit is decreased patient movement artifact, especially in pediatric patients. "In
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    16. Enhanced optical coherence tomography for anatomical mapping

      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...
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    17. Optovue Receives FDA Clearance for Cornea/Anterior Module for RTVue

      Fremont, CA — October 25, 2007 - Optovue, Inc., the first company to introduce a Fourier-domain optical coherence tomography (FD-OCT) system to the US market, today announced that on September 28, FDA 510(k) clearance was received for its Cornea/Anterior Module (CAM). The CAM is an optional attachment for the RTVue, Optovue’s high-speed and high-resolution FD-OCT device for retinal imaging. The CAM add-on enhances the RTVue by enabling five-micron resolution, high-magnification imaging of the co
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    18. Optical coherence tomography and disease subtype in multiple sclerosis

      Objective: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). Methods: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). Results: MS ON eyes had decreased RNFL thickness (84.2 µm) compared to controls (102.7 µm) (p p p p p ...
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