1. Articles in category: Ophthalmology

    121-144 of 12741 « 1 2 ... 3 4 5 6 7 8 9 ... 529 530 531 »
    1. Patience needed to grow OCTA adoption in practice

      Patience needed to grow OCTA adoption in practice

      Even though OCT angiography is a helpful diagnostic tool, there are practical challenges to implementing this technology in practice. According to the ASRS 2019 Preferences and Trends survey, only 28.6% of U.S. respondents said they used OCTA in clinical practice and found it useful. Thirty-two percent said they did not have access, nor did they intend to gain access any time soon. “It is a great technology, and it can be helpful in ambiguous cases, but the key takeaway about OCT angiography is: Be patient,” Roger A . Goldberg , MD, MBA, said in a presentation giving a “real-world” perspective ...

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    2. Widefield Swept Source OCTA in Retinitis Pigmentosa

      Widefield Swept Source OCTA in Retinitis Pigmentosa

      1) Background: To evaluate superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), perfusion density (PD), and vessel length density (VLD) in macular and near/mid periphery regions in patients with retinitis pigmentosa (RP) using widefield swept source optical coherence tomography angiography (WSS-OCTA). (2) Methods: Twelve RP patients (20 eyes) and 20 age-matched subjects (20 eyes) were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). Quantitative analysis was performed in the macular and peripheral regions. The main outcome measures were SCP, DCP, CC, PD, and VLD in central and peripheral areas. (3 ...

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    3. Anterior segment optical coherence tomographic characterisation of keratic precipitate

      Anterior segment optical coherence tomographic characterisation of keratic precipitate

      Background/objectives Anterior segment optical coherence tomography (AS-OCT) can be used to visualise keratic precipitates (KPs) on the corneal endothelium. However, there has been no correlation between characteristic clinical appearances of KPs and AS-OCT morphology. We wished to assess the potential diagnostic role of AS-OCT in patients presenting with inflammatory eye disease and KPs. Subjects/methods Six patients with inflammatory KPs were compared to one patient with infective interface keratitis following Descemet Membrane Endothelial Keratoplasty (DMEK) and one patient with endothelial pigment. AS-OCT was performed in each case and morphological features of the KPs were compared. Reflectivity of KPs was ...

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    4. Vascular changes with optical coherence tomography angiography during aura of migraine: A case report

      Vascular changes with optical coherence tomography angiography during aura of migraine: A case report

      Purpose: To demonstrate macular and optic disk vessel changes by optical coherence tomography angiography during and after a migraine attack with aura Methods: Case report Results: A 34-year-old healthy female patient was evaluated by optical coherence tomography angiography imaging during visual aura with phosphenes in the left visual field. Optical coherence tomography angiography imaging showed diffuse narrowing of the retinal vessels, decreased radial peripapillary capillary density, and decreased superficial and deep foveal vessel density in the right eye. These changes improved 3 hours after visual aura. The patient suffered from right eye pain and right-sided headache, which are typical for ...

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    5. Numerical method for axial motion artifact correction in retinal spectral-domain optical coherence tomography

      Numerical method for axial motion artifact correction in retinal spectral-domain optical coherence tomography

      A numerical method that compensates image distortions caused by random fluctuations of the distance to an object in spectral-domain optical coherence tomography (SD OCT) has been proposed and verified experimentally. The proposed method is based on the analysis of the phase shifts between adjacent scans that are caused by micrometer-scale displacements and the subsequent compensation for the displacements through phase-frequency correction in the spectral space. The efficiency of the method is demonstrated in model experiments with harmonic and random movements of a scattering object as well as during in vivo imaging of the retina of the human eye.

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    6. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH RETINITIS PIGMENTOSA–ASSOCIATED CYSTOID MACULAR EDEMA

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH RETINITIS PIGMENTOSA–ASSOCIATED CYSTOID MACULAR EDEMA

      Purpose: To investigate the microstructure of cystoid macular edema (CME) in retinitis pigmentosa (RP) and the associated vascular changes using optical coherence tomography (OCT) angiography. Methods: In this retrospective study, we included 42 eyes of 21 patients with RP and age-similar normally sighted controls who underwent both OCT and optical coherence tomography angiography . Using OCT, spatial distribution of CME and the retinal layer, which CME located, was examined. Optical coherence tomography angiography images of the superficial capillary plexus and deep capillary plexus were obtained. Foveal and parafoveal flow densities in each layer and foveal avascular zone area were measured. Results ...

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    7. Optical coherence tomography angiography in diabetes: A review

      Optical coherence tomography angiography in diabetes: A review

      Diabetic retinopathy is a common diabetes complication representing a heavy burden in terms of visual impairment and heath expenditure. Optical coherence tomography angiography is a relatively new imaging method and has proven to be a powerful tool in the analysis of diabetic retinopathy common features, including microaneurysms, intraretinal microvascular abnormalities, or neovascularization, as well as in research field, challenging the gold standard of fluorescein angiography. Many studies underlined the vascular impairment observed through optical coherence tomography angiography and its typical parameters such as vessel length density, foveal avascular zone, and fractal dimension. Choriocapillaris involvement in the pathogenesis of diabetic retinopathy ...

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    8. ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen

      ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen

      Purpose: Macular edema is a common retinal disease which may leave important anatomical and functional sequelaes. Directional fundus imaging consists of comparing on- and off-axis images to reveal angle-dependent reflectance properties of fundus structures, which may be related to misaligned photoreceptors . Here, we analyzed directional optical coherence tomography (OCT) and flood-illumination adaptive optics ophthalmoscopy images to detect evidence of misaligned photoreceptors following macular edema . Methods: Transversal, observational study. Nine patients having recovered a normal macular profile after macular edema due to retinal vein occlusion were included. For each patient, a reference OCT scan (i.e., with the incident beam normal ...

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    9. Quantification of Retinal Nerve Fibre Layer Thickness on Optical Coherence Tomography with a Deep Learning Segmentation-Free Approach

      Quantification of Retinal Nerve Fibre Layer Thickness on Optical Coherence Tomography with a Deep Learning Segmentation-Free Approach

      This study describes a segmentation-free deep learning (DL) algorithm for measuring retinal nerve fibre layer (RNFL) thickness on spectral-domain optical coherence tomography (SDOCT). The study included 25,285 B-scans from 1,338 eyes of 706 subjects. Training was done to predict RNFL thickness from raw unsegmented scans using conventional RNFL thickness measurements from good quality images as targets, forcing the DL algorithm to learn its own representation of RNFL. The algorithm was tested in three different sets: (1) images without segmentation errors or artefacts, (2) low-quality images with segmentation errors, and (3) images with other artefacts. In test set 1 ...

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    10. Optical coherence tomography of the retina in schizophrenia: Inter-device agreement and relations with perceptual function

      Optical coherence tomography of the retina in schizophrenia: Inter-device agreement and relations with perceptual function

      Background Optical coherence tomography (OCT) studies have demonstrated differences between people with schizophrenia and controls. Many questions remain including the agreement between scanners. The current study seeks to determine inter-device agreement of OCT data in schizophrenia compared to controls and to explore the relations between OCT and visual function measures. Methods Participants in this pilot study were 12 individuals with schizophrenia spectrum disorders and 12 age- and sex-matched controls. Spectralis and Cirrus OCT machines were used to obtain retinal nerve fiber layer (RNFL) thickness and macular volume. Cirrus was used to obtain ganglion cell layer + inner plexiform layer (GCL + IPL ...

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    11. Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, a Cross-Sectional Study

      Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, a Cross-Sectional Study

      Background: Optic neuritis (ON) is an inflammatory demyelinating lesion in the optic nerve, which is strongly associated with multiple sclerosis (MS). Optical coherence tomography (OCT) is a noninvasive technique for the evaluation of the retinal layers. Our aim was to examine OCT metrics including retinal nerve fiber layer thickness (RNFLT), and total macular volume (TMV), in MS subtypes and their relationship with duration, first manifestation, and severity of disease. Material and Methods: In this cross-sectional study, patients with a definite diagnosis of MS underwent complete ophthalmic and neurologic examination. OCT parameters including TMV and RNFLT were compared between MS subtypes ...

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    12. OCT Angiography Features of Neovascularization as Predictive Factors for Frequent Recurrence in Age-Related Macular Degeneration

      OCT Angiography Features of Neovascularization as Predictive Factors for Frequent Recurrence in Age-Related Macular Degeneration

      Purpose To investigate the features of neovascularization (NV) in eyes with neovascular age-related macular degeneration (NVAMD) using optical coherence tomography angiography (OCTA) according to the treatment interval of intravitreal aflibercept injection (IVI). Design Retrospective, interventional, comparative case series. Methods Patients with type 1 NV treated with the “pro-re-nata” regimen after three loading IVI were classified into two groups based on the numbers of treatments during 12 months, specifically a stable group who required less than two injections and an unstable group who required more than three injections. Quantitative features of OCTA including NV area, NV length, NV density, endpoint density ...

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    13. New Methods for Spatial Analysis of Thickness in Optical Coherence Tomography

      New Methods for Spatial Analysis of Thickness in Optical Coherence Tomography

      The retina is the most accessible alive neuronal tissue and is relevant not only for ophthalmology but also for neuroscience, because of the increasing evidence that it shows degeneration processes similar to those found in the brain of patients with Alzheimer’s disease and Amyotrophic Lateral Sclerosis. Optical Coherence Tomography (OCT) provides retinal scanning noninvasively, in few seconds, at low cost, and with a spatial resolution thousand times finer than what today is feasible in the living brain. But OCT data have some features derived from its 3D structure that render unsuited classical data analysis methods. Current proposal is to ...

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    14. Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer

      Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer

      Purpose To compare the accuracy of the five commonly used intraocular lens (IOL) calculation formulas integrated to a swept-source optical biometer, the IOLMaster 700, and evaluate the extent of bias within each formula for different ocular biometric measurements. Methods The study included patients undergoing cataract surgery with a ZCB00 IOL implant, using IOLMaster 700 optical biometry. A single eye per patient was included in the final analysis for a total of 324 cases. The SRK/T, Hoffer Q, Haigis, Holladay 2, and Barrett Universal II formulas were evaluated. The correlations between the refractive prediction errors calculated using the five formulas ...

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    15. Deep OCT Angiography Image Generation for Motion Artifact Suppression

      Deep OCT Angiography Image Generation for Motion Artifact Suppression

      Eye movements, blinking and other motion during the acquisition of optical coherence tomography (OCT) can lead to artifacts, when processed to OCT angiography (OCTA) images. Affected scans emerge as high intensity (white) or missing (black) regions, resulting in lost information. The aim of this research is to fill these gaps using a deep generative model for OCT to OCTA image translation relying on a single intact OCT scan. Therefore, a U-Net is trained to extract the angiographic information from OCT patches. At inference, a detection algorithm finds outlier OCTA scans based on their surroundings, which are then replaced by the ...

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    16. Anterior chamber configuration changes after phacoemulsification and IOL implantation measured by anterior segment optical coherence tomography

      Anterior chamber configuration changes after phacoemulsification and IOL implantation measured by anterior segment optical coherence tomography

      Objective: To measure early changes in anterior chamber morphology after phacoemulsification and IOL implantation using anterior segment optical coherence tomography. Materials and Methods: Prospective consecutive interventional study measuring the anterior chamber configuration changes in twenty (20 eyes) after 1 month of phacoemulsification and posterior chamber IOL implantation. Results: Showing significant difference regarding nasal, superior, temporal and inferior angle measured by anterior segment optical coherence tomography before and after phacoemulsification operation with p.value were (0.027_0.009_0.02_0.012) respectively. Conclusion: Quantitative values showed the anterior chamber angle (ACA), measured using AS-OCT, has increased following uneventful phacoemulsification and IOL implantation.

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    17. SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF PACHYCHOROID NEOVASCULOPATHY IN RETINITIS PIGMENTOSA

      SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF PACHYCHOROID NEOVASCULOPATHY IN RETINITIS PIGMENTOSA

      Purpose: To report a rare case of pachychoroid neovasculopathy in retinitis pigmentosa (RP) and to describe its features and changes after treatment with bevacizumab as documented by swept-source optical coherence angiography. Methods: A case report of a 69-year-old man with a history of RP who presented at our clinic with an acute decrease in visual acuity (Best corrected visual acuity) in his left eye. Results: Upon the first examination, best-corrected visual acuity in the left eye was 20/50. Fundus examination and fundus autofluorescence showed bilaterally typical features of RP, and enhanced depth imaging–optical coherence tomography revealed a pachychoroid ...

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    18. Early Diagnostic Value of Optical Coherence Tomography in The Clinical Prediction Model for Optic Nerve Injury in Saddle Space Occupying Patients

      Early Diagnostic Value of Optical Coherence Tomography in The Clinical Prediction Model for Optic Nerve Injury in Saddle Space Occupying Patients

      In this study, 50 patients with anterior ischemic optic neuropathy due to saddle block were selected as the experimental group, and 50 healthy subjects were used as the control group to conduct a study. The best corrected visual acuity examination, optical coherence tomography and visual evoked potential examination were performed on the two groups. The results of the study showed that the majority of patients were middle-aged and older people over the age of 50, but the youngest patients were only 37 years old. After various examinations, it was found that patients with optic nerve injury had a significant reduction ...

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      Mentions: Yan Li
    19. Vitreoretinal interface slab in optical coherence tomography-angiography for detecting diabetic retinal neovascularization

      Vitreoretinal interface slab in optical coherence tomography-angiography for detecting diabetic retinal neovascularization

      Purpose To compare neovascularization (NV) identified in proliferative diabetic retinopathy (PDR) eyes by wide-field swept-source optical coherence tomography angiography (SS-OCTA) using vitreoretinal interface (VRI) slab images, composed by automated and manual segmentation, with that identified by fluorescein angiography (FA). Design Retrospective study. Subjects Forty-two eyes of 30 treatment-naïve PDR patients who visited the outpatient clinic of the Ophthalmology Department of Shinshu University from June 2018 through October 2019. Methods All patients underwent comprehensive ophthalmological examinations, including SS-OCTA and FA. Main Outcome Measures. NV detected by en face SS-OCTA 15 × 15-mm VRI slab images and FA in the same 15 ...

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    20. Quantitative analysis of optical coherence tomography angiography metrics in diabetic retinopathy

      Quantitative analysis of optical coherence tomography angiography metrics in diabetic retinopathy

      Purpose: To evaluate the correlation of the visual acuity and diabetic retinopathy stage using optical coherence tomography and optical coherence tomography angiography metrics. Methods: In this prospective study, optical coherence tomography and optical coherence tomography angiography images of patients with different stages of diabetic retinopathy were obtained. In optical coherence tomography angiography images, the size of foveal avascular zone, central macular thickness, and vessel density at superficial and deep capillary layers of the macula were measured. In optical coherence tomography images, the presence of intraretinal cyst, disorganization of retinal inner layer, and ellipsoid zone and external limiting membrane disruption were ...

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    21. Analysis of Choroidal Vascularity Index in Keratoconus Patients Using Swept-Source Optical Coherence Tomography-Based Binarization Techniques

      Analysis of Choroidal Vascularity Index in Keratoconus Patients Using Swept-Source Optical Coherence Tomography-Based Binarization Techniques

      Purpose . To analyse the vascular density of the choroid in a keratoconus (KC) population using swept-source optical coherence tomography (SS-OCT). Methods . Prospective, noninterventional study that analysed 97 eyes from 52 KC patients and 145 eyes from 89 healthy controls. The sample was divided in four different age groups. Inclusion criteria were topographic diagnosis of KC using Pentacam, axial length shorter than 26 mm, good quality of the images, and no other systemic or ocular diseases. A 12 mm horizontal single-line SS-OCT b-scan was performed to create a choroidal thickness (CT) profile. Validated automated segmentation and binarization were used in order ...

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    22. Clinical Implications of Suspended Scattering Particles in Motion Observed by Optical Coherence Tomography Angiography

      Clinical Implications of Suspended Scattering Particles in Motion Observed by Optical Coherence Tomography Angiography

      The objective of this study was to investigate the relationship between suspended scattering particles in motion (SSPiM) in optical coherence tomography angiography (OCTA) and treatment response in diabetic macular edema (DME). We retrospectively reviewed the medical records of patients diagnosed with DME who had undergone intravitreal injection. The optical density ratio (ODR) of the intraretinal cyst and the numbers of hyperreflective foci from OCT images and SSPiM from OCTA images were compared, and their association with treatment response was analyzed. Forty-five eyes from 45 patients were included in this study. Twenty-four patients were treated with anti-vascular endothelial growth factor, and ...

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    23. Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy

      Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy

      Purpose To quantify the structural and perfusion changes in choriocapillaris in chronic central serous chorioretinopathy after half-dose photodynamic therapy by using spectral-domain optical coherence tomography and optical coherence tomography angiography. Methods This retrospective interventional case series examined the eyes of patients with central serous chorioretinopathy. Patients underwent full ophthalmic examinations, including spectral-domain optical coherence tomography and angiography, prior to and 1, 3, and 6 months after the treatment. Clinical and tomographic features of the choriocapillaris and choroidal thickness and vascular changes were evaluated by assessing flow signal voids. Results All 56 eyes of 56 patients showed complete resolution of subretinal ...

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    24. Associations Between Retina and Brain Function

      Associations Between Retina and Brain Function

      Case-control studies and meta-analysis have reported that several fundus features, especially the thickness of the peripapillary retinal nerve fiber layer, are related to the brain degeneration and cognitive impairment. In our study, we aim to quantitatively assess retina features using OCT and define its associations with brain development and intelligence in children.

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