1. Articles in category: Ophthalmology

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    1. Assessment of anterior segment parameters under photopic and scotopic conditions in Indian eyes using anterior segment optical coherence tomography

      The Eye Research Foundation, Vijaya Hospital, Chennai, India Correspondence Address: Dacosta Shaun The Eye Research Foundation, Vijaya Hospital, 180 NSK Salai, Chennai - 600 026 India Purpose: To compare the anterior segment parameters in photopic and scotopic conditions using anterior segment optical coherence tomography (AS OCT) in Indian eyes. Materials and Methods: One hundred eyes of 100 normal subjects of both sexes, aged 19 to 76 years, underwent anterior segment evaluation by AS OCT (Vis
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    2. Maculopathy in uveitis of juvenile idiopathic arthritis: an optical coherence tomography study

      Aim: The aim of this study was to examine the frequency and characteristics of macular lesions observed in juvenile idiopathic arthritis (JIA) uveitis, using optical coherence tomography (OCT). Methods: In this cross-sectional study, 38 consecutive patients were recruited from a tertiary referral center in uveitis. All eyes with JIA uveitis underwent complete ophthalmic examination including OCT 3. Exclusion criterion was the inability to obtain OCT scans. Flare and visual acuity were also analysed by using linear regression. Results: We analysed foveal thickness (FT) and central foveal thickness (CFT), using software mapping, to describe macular lesions in 61 eyes. Maculopathy was ...
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    3. Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy

      Aims: The aim of the study was to assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV). Methods: Intravitreal bevacizumab (1 mg) was injected into 11 eyes of 11 patients with PCV in this retrospective, interventional case series. The main outcome measure was the change in the polypoidal vessels on indocyanine green angiography (IA) 3 months after injection. The foveal height determined by optical coherence tomography and the best-corrected visual acuity (BCVA) also were evaluated before and after treatment. Results: At baseline, subretinal fluid was observed in five eyes and a pigment epithelial detachment in ...
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    4. Intravitreal triamcinolone versus bevacizumab for treatment of refractory diabetic macular oedema (ibeme study)

      Background/aims: The aim of this study was to compare the morphological and visual acuity outcomes associated with a single intravitreal injection of triamcinolone acetonide versus bevacizumab for the treatment of refractory diffuse diabetic macular oedema. Methods: Twenty-eight patients were randomly assigned to receive a single intravitreal injection of either 4 mg/0.1 ml triamcinolone acetonide or 1.5 mg/0.06 ml bevacizumab. Comprehensive ophthalmic evaluation was performed at baseline and at weeks 1, 4, 8 (±1), 12 (±2) and 24 (±2) after treatment. Main outcome measures included central macular thickness measured with optical coherence tomography (OCT) and ...
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    5. Trans-Tenon's retrobulbar triamcinolone acetonide injection for macular oedema related to branch retinal vein occlusion

      Background: The aim of the study was to evaluate the safety and effectiveness of trans-Tenon’s retrobulbar triamcinolone acetonide (TA) injection for macular oedema associated with branch retinal vein occlusion (BRVO). Methods: We reviewed the medical records of 50 consecutive patients with macular oedema associated with BRVO who were treated with trans-Tenon’s retrobulbar TA injection (20 mg) as initial treatment for a follow-up period of at least 12 months. Foveal thickness determined by optical coherence tomography, visual acuity, intraocular pressure (IOP) and cataract progression were measured. Results: The mean duration between oedema onset and TA injection was 4.9 ...
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    6. Central visual field impairment during and following cystoid macular oedema

      Aim: To determine differential light threshold values obtained with the Micro Perimeter 1 (MP1) in uveitis patients suffering from cystoid macular oedema (CMO) and to compare these measures to retinal thickness. Methods: Static threshold perimetry was performed with the MP1 Microperimeter in 27 eyes of 21 patients with a history of chronically recurring CMO. Active CMO was confirmed in 19 eyes. Eight eyes with a history of recurrent CMO were found to have normal foveal contours in optical coherence tomography (OCT). Differential light threshold values (MP1) were compared with the corresponding retinal thickness measures (OCT). Results: Mean differential threshold values ...
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    7. Degree of angle closure and extent of peripheral anterior synechiae: an anterior segment OCT study

      Aims: To evaluate the relationship between angle width as determined by anterior segment optical coherence tomography (AS-OCT) and the presence of peripheral anterior synechiae (PAS). Methods: This was a prospective observational case series in which 203 subjects with primary angle closure or open angles were recruited. Images of the nasal, temporal and inferior angles were obtained with AS-OCT in dark conditions. Subjects then underwent gonioscopy by an independent examiner who was masked to the AS-OCT findings. PAS were identified by gonioscopy and defined as abnormal adhesions of the iris to the angle that were at least half a clock hour ...
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    8. Half-top-hat a new wound configuration for penetrating keratoplasty

      Aims: To describe a new, simpler method of achieving the advantages of a lamellar wound configuration in penetrating keratoplasty (PKP)—the half-top-hat (HTH) configuration. Methods: The donor corneal button was prepared in a top-hat configuration, as previously described. It consisted of a central, full-thickness part, 7–8 mm in diameter, surrounded by a peripheral lamellar wing of deep stroma and endothelium that was 0.5 mm in width (wing diameter 8–9 mm). The recipient bed was prepared by a straight full thickness trephination with a suction trephine. The donor button was positioned by sliding the peripheral wing under the ...
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    9. Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography

      M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, C. K. Hitzenberger We describe a novel instrument capable of acquiring, simultaneously, adaptive optics enhanced scanning laser ophthalmoscopy and optical coherence tomography (OCT) images of the human cone mosaic in vivo. The OCT system is based on transversal scanning of the sample with a line scan rate of 14 kHz, ... [Opt. Lett. 33, 22-24 (2008)]
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    10. Stratus OCT in Dominant Optic Atrophy: Features Differentiating it From Glaucoma.

      PURPOSE: To describe the Stratus optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness profile of dominant optic atrophy (DOA), to differentiate it from that of glaucoma. METHODS: RNFL thickness was measured using Stratus OCT in 32 eyes of 16 DOA patients. RESULTS: The temporal-most clock hour measurement was outside the 95% normal limit in 29 of the 32 DOA eyes (90.6%). The pattern of RNFL damage was bilaterally symmetrical in location and severity in all subjects. CONCLUSION: Stratus OCT shows characteristic findings differentiating DOA from glaucoma. PMID: 18091450 [PubMed - in process]
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    11. Inexpensive Glaucoma Assessment Tool Can Track MS Activity

      University at Buffalo Reporter - New research by neurologists at the University at Buffalo has shown that a technique called optical coherence tomography, or OCT, a simple and inexpensive measure employed currently to assess glaucoma, also could be used as a surrogate marker of ...
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    12. Fourier domain optical coherence tomography with a linear-in-wavenumber spectrometer.

      Related Articles Fourier domain optical coherence tomography with a linear-in-wavenumber spectrometer. Opt Lett. 2007 Dec 15;32(24):3525-7 Authors: Hu Z, Rollins AM We describe Fourier domain optical coherence tomography equipped with a novel linear-in-wavenumber spectrometer. The presented device linearizes the spectral dispersion of the spectrometer in wavenumber using a specifically designed prism. The spectral linearity in wavenumber makes numerical interpolation into wavenumber unnecessary, reduces computing time, and furthermore results in improvement of the falloff of signal with image range inherent to frequency-domain optical coherence tomography imaging. Experiments demonstrate the improvement of the falloff and agree with the expected ...
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    13. Correlation between retinal nerve fibre layer thickness and retinal sensitivity

      Purpose: To evaluate the relationship between retinal nerve fibre layer (RNFL) thickness measured by optical coherence tomography (OCT) and light threshold values obtained with the Micro Perimeter 1 (MP1). Methods: Forty-nine normal subjects and 37 glaucoma patients were included. Thickness of the RNFL around the optic disc was measured with Stratus OCT scans, and static threshold perimetry was performed with the MP1 at the same visit. Total average and mean 12-clock-hour RNFL thickness were measured with Stratus OCT. An automated 4-2-1 staircase strategy with Goldmann III stimuli was used for MP1. The correspondence between Stratus OCT and MP1 RNFL measurements ...
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    14. Accuracy of cornea and lens biometry using anterior segment optical coherence tomography

      Mark C. M. Dunne, Leon N. Davies, and James S. Wolffsohn We assess the accuracy of the Visante anterior segment optical coherence tomographer (AS-OCT) and present improved formulas for measurement of surface curvature and axial separation. Measurements are made in physical model eyes. Accuracy is compared for measurements of corneal thickness (d) and ante ... [J. Biomed. Opt. 12, 064023 (2007)] published Tue Dec 18, 2007.
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    15. Great Strides Moved MS Research Forward During 2007

      National Multiple Sclerosis Society Published: December 14, 2007 The year 2007 saw rapid research progress in the fields of science and medicine that impact our understanding of the unpredictable neurological disease multiple sclerosis. Thanks to its generous contributors, the National MS Society was able to invest over $46 million this year into over 440 new and ongoing MS research projects as part of its international effort to prevent, treat and cure MS. Significant advances have been made in
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    16. Comparison of Optic Nerve Head Topography and Visual Field in Eyes with Open-angle and Angle-closure Glaucoma.

      Related Articles Comparison of Optic Nerve Head Topography and Visual Field in Eyes with Open-angle and Angle-closure Glaucoma. Ophthalmology. 2007 Dec 13; Authors: Boland MV, Zhang L, Broman AT, Jampel HD, Quigley HA OBJECTIVE: To compare the optic disc and visual field (VF) alterations in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). DESIGN: Observational case series. PARTICIPANTS: A total of 146 persons (217 eyes), 110 with POAG and 36 with PACG, recruited from a university glaucoma service. METHODS: Each subject underwent visual acuity measurement, applanation tonometry, gonioscopy, slit-lamp examination, dilated optic disc and retinal examination, axial eye length ...
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    17. Chloroquine retinopathy: lipofuscin- and melanin-related fundus autofluorescence, optical coherence tomography and multifocal electroretinography.

      Related Articles Chloroquine retinopathy: lipofuscin- and melanin-related fundus autofluorescence, optical coherence tomography and multifocal electroretinography. Doc Ophthalmol. 2007 Dec 16; Authors: Kellner U, Kellner S, Weinitz S Purpose To evaluate melanin-related near-infrared fundus autofluorescence (NIA, excitation 787 nm, emission > 800 nm), lipofuscin-related fundus autofluorescence (FAF, excitation 488 nm, emission >500 nm), optical coherence tomography (OCT), and multifocal electroretinography (mfERG) in patients with chloroquine (CQ) retinopathy. Methods Two patients with progressed CQ retinopathy underwent clinical examination, ISCEV mfERG evaluation, and FAF and NIA imaging using a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2) with either a 30 degrees or wide-angle ...
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    18. Birefringence characterization of biological tissue by use of optical coherence tomography.

      Authors: Everett MJ, Schoenenberger K, Colston BW, Da Silva LB An improved polarization-sensitive optical coherence tomography (OCT) system is developed and used to measure birefringence in porcine myocardium tissue and produce two-dimensional birefringence mapping of the tissue. Signal-to-noise issues that cause systematic measurement errors are analyzed to determine the regime in which such measurements are accurate. The advantage of polarization-sensitive OCT systems over standard OCT systems in avoiding image artifacts caused by birefringence is also demonstrated. PMID: 18084468 [PubMed - in process]
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