1. Articles in category: Ophthalmology

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    1. Customized corneal profiling

      A customized corneal profile is provided by combining corneal topography data with captured wavefront aberration data to form a course of refractive treatment of the eye. In one embodiment, the captured wavefront data is employed within the area of a pupil, while the corneal topography data is employed in the area outside of the pupil. In other embodiments, the topography data is adjusted based on the wavefront data, a course of refractive treatment is simulated and displayed upon the topography data, and an initial evaluation of the suitability of a patient for treatment is performed based on the topography data.
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      Mentions: Bausch & Lomb
    2. Optical coherence tomography in anterior segment imaging

      Purpose: To evaluate the ability of optical coherence tomography (OCT), designed primarily to image the posterior segment, to visualize the anterior chamber angle (ACA) in patients with different angle configurations. Methods: In a prospective observational study, the anterior segments of 26 eyes of 26 patients were imaged using the Zeiss Stratus OCT, model 3000. Imaging of the anterior segment was achieved by adjusting the focusing control on the Stratus OCT. A total of 16 patients had abnormal angle configurations including narrow or closed angles and plateau irides, and 10 had normal angle configurations as determined by prior full ophthalmic examination ...
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    3. Optical coherence tomography evidence of rapid progression from vitreomacular traction to full thickness macular hole

      The authors present a case of a patient with idiopathic vitreomacular traction who subsequently developed a full thickness macular hole 3 weeks following the onset of metamorphopsia. Vitreomacular traction is a well described phenomenon and has been known to resolve spontaneously and in this patient the conservative approach was adopted initially. However, she progressed rapidly to a full thickness macular hole and therefore, the authors recommend close monitoring of such patients with a view to early vitrectomy to prevent progressive morbidity.
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    4. Measurement of gradient refractive index profile of crystalline lens of fisheye in vivo using optical coherence tomography

      Measurement of gradient refractive index profile of crystalline lens of fisheye in vivo using optical coherence tomography
      We report the use of optical coherence tomography (OCT) for noninvasive measurement of the refractive index profile of a crystalline lens of a fisheye. The approach exploits the fact that OCT provides a direct measurement of the optical path of the light traveled through the medium. The gradient refractive index profile for the crystalline lens was retrieved by iterative fitting of the optical path calculated by the ray tracing method with that experimentally measured using OCT. The estimated error in refractive index is approximately 1%. The measured gradient refractive index and Matthiessen’s ratio (ratio of focal length to lens ...
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    5. Glaucoma detection using different Stratus optical coherence tomography protocols

      Purpose: To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols. Methods: Stratus OCT data for 90 healthy subjects and 62 glaucoma patients with mild or moderate visual field loss were prospectively collected and analysed using four RNFL thickness protocols that differed in terms of image resolution and number of scans. Cut-off levels corrected for age and refractive error were defined by reference values derived from an independent normal database. Sensitivity and specificity were calculated for average RNFL thickness for the full circle scan, and for ...
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    6. Optical coherence tomography of chorioretinal and choroidal folds

      Purpose: To report the optical coherence tomography (OCT) findings in cases of chorioretinal and choroidal folds. Methods: Eight subjects with folds of the fundus of the eye were examined with fundus photography, fluorescein angiography, B-scan ultrasonography and Stratus OCT. Results: Two types patterns were found on OCT. Five cases showed undulating retinal as well as retinal pigment epithelial lines of normal thickness; these were defined as chorioretinal folds. The posterior vitreous surface often adhered to the crests of the folds only. Three cases exhibited a wavy appearance of the retinal pigment epithelium and a flat retinal surface; these were classified ...
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    7. MIT team takes high-res, 3-D images of eye

      MIT team takes high-res, 3-D images of eye
      In work that could improve diagnoses of many eye diseases, MIT researchers have developed a new type of laser for taking high-resolution, 3-D images of the retina, the part of the eye that converts light to electrical signals that travel to the brain. The research will be presented at the Conference on Lasers and Electro-Optics and the Quantum Electronics and Laser Science Conference in Baltimore on May 10.
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    8. Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography

      Purpose To compare the macular retinal thickness and macular volume between subjects with high myopia and non-myopia. Methods This prospective nonrandomized, comparative study recruited healthy subjects with high myopia subjects, defined as a spherical equivalence (SE) over - 6 dioptres (D) or AXL26.5 mm and the best corrected visual acuity better than 20/25, and subjects with non-myopia, defined as an with SE between 1.5D and - 1.5 D and the BCVA better than 20/25. Optical coherence tomography was performed in each eye. Results Eighty high myopic eyes and 40 non-myopic eyes were included. The mean age of ...
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    9. Optical Coherence Tomography of the Macula in Congenital Achromatopsia

      Optical Coherence Tomography of the Macula in Congenital Achromatopsia
      purpose. It is known that symptoms of congenital achromatopsia are caused by the lack of functioning cones, but there are very few published data on histologic changes in the retina in these cases. This study was conducted to examine in vivo the anatomic structure of the retina of patients with achromatopsia. methods. Fifteen eyes of eight patients with congenital achromatopsia and 18 eyes of nine control subjects were examined by optical coherence tomography. Radial 6-mm scans were taken of the macula. The thickness of the neuroretina was measured both automatically and manually. Measurements were taken at the foveola and at ...
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    10. Relation of optical coherence tomography and unusual angiographic leakage patterns in central serous chorioretinopathy

      Purpose To investigate the anatomic basis of atypical angiographic leaks in central serous chorioretinopathy (CSC) with optical coherence tomography (OCT). Methods Fluorescein angiography (FA) and OCT were performed in three eyes of three patients (two men, one woman) with CSC. The angiographic leaks were treated with transpupillary thermotherapy (TTT) in two patients with long-standing CSC. The investigations were repeated in the treated patients during follow-up visits. Results Clinically, all patients demonstrated typical CSC; the female patient had subretinal fibrin under the detachment. FA showed unusual leakage patterns and OCT revealed bridging tissue connecting the pigment epithelial detachment (PED) to the ...
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    11. Assessment of the posterior segment of the cat eye by optical coherence tomography (oct)

      Objectives To assess the feasibility of optical coherence tomography (OCT) for examining the cat ocular fundus, to provide normative data on retinal thickness in different fundus regions, and to demonstrate selected surgically induced vitreoretinal pathologies in the cat. Animal studied Forty-five eyes of 28 healthy domestic cats and two eyes of domestic cats that had undergone subretinal implantation surgery for a visual prosthesis were examined. Procedures An optical coherence tomograph (Zeiss-Humphrey) was used to examine the anesthetized animals. At least five vertical and five horizontal scans in regular distribution were recorded for each cat including (1) the peripapillary region, (2 ...
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    12. Optical coherence tomography in a patient with tobacco-alcohol amblyopia

      Aim To report optical coherence tomography (OCT) finding in a patient with tobacco-alcohol amblyopia. Methods A 45-year-old man presented with a gradual decrease in vision over 4 years. He had smoked a half to one pack of cigarettes per day and had consumed 350 cc of gin per day for 30 years. A detailed ophthalmologic examination was performed. Results His corrected visual acuities were 20/800 OD and 20/200 OS. A Goldmann visual field examination showed ceco-central scotomas in both eyes. OCT using a peripapillary Fast RNFL (retinal nerve fiber layer) programme showed a small decrease in the RNFL ...

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    13. Correlation between microaneurysm closure rate and reduction in macular thickness following laser photocoagulation of diabetic macular edema

      Aim To correlate the microaneurysmal closure rate measured on fundus fluorescein angiography (FFA) with reduction in macular thickness observed on optical coherence tomography (OCT) following laser photocoagulation of diabetic macular edema. Materials and methods A prospective observational case series. Fifty patients (50 eyes) of type II diabetes mellitus with clinically significant macular oedema (CSME) underwent focal/grid laser photocoagulation. OCT and FFA were performed at baseline and at 2 and 12 weeks following laser photocoagulation to measure the change in macular thickness and the number of leaking microaneurysms respectively. Statistical analysis was performed using paired-ttest and Pearson's correlation test ...
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      Mentions: Amod Gupta
    14. Step by Step Optical Coherence Tomography with Photo CD-ROM (Book)

      Step by Step Optical Coherence Tomography with Photo CD-ROM (Book)
      In "Step by Step OCT" we have endeavored to create a small book conveying only those things that would be important for the non-academic day to day user of OCT. A total of 25 chapters cover all aspects of the subject. Interprets OCT procedures in a simple and user-friendly manner. Describes various disease patterns with typical examples. Emphasizes macular, retinal and optic nerve head diseases. Summarizes important points in the tables and boxes. Useful equally to the students as well as ophthalmologist either in training or in practice.
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    15. Optovue, an ocular disease treatment co., raises $10.5M

      Optovue, a Fremont, Ca. maker of devices that improve diagnosis and treatment of ocular disease, has received $10.5 million in second round of funding, the company announced said. Based on high speed and high resolution Fourier-Domain OCT technology, the products help with retina conditions such as macular degeneration, diabetic retinopathy, glaucoma, and other macular diseases. Trevi Health Ventures led the round, which also included Acorn Campus Ventures, HNQ Asia Pacific, Harbinger Venture Management, iD SoftCapital and other individual investors. Optovue raised about $4.5 million in a first round
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      Mentions: Optovue Jay Wei
    16. Optovue raises $10.5M

      Ophthalmic device maker Optovue Corp. said Friday it received $10.5 million in second-round funding. Fremont-based Optovue said New York-based Trevi Health Ventures led the investment, followed by several partners from Optovue's previous funding round. The company said the money will be used to expand production of the its RTVue device, which was recently released outside the United States, as well as advance development of the company's product pipeline. Optovue also appointed John Moore, forme
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    17. Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy

      Aim: A comparison of retinal thickness (RT) measurements with optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (DM) and no or minimal diabetic retinopathy (DR) versus healthy controls. Methods: Fifty-three patients with type 1 DM with no or minimal DR underwent full ophthalmic examination, fundus photography and OCT. Mean RT measured by OCT was calculated for the central fovea, the fovea, the pericentral and the peripheral area of the macula, and compared to healthy controls. Results: Mean RT in the pericentral area was lower in patients with minimal DR (267 µm ± 20 µm; n = 23) compared to ...

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    18. Targeted stent placement and multi-stent therapy

      A trabecular flow model for producing treatment recommendations for patients with elevated intraocular pressure is disclosed. One method includes providing intraocular pressure measurements for a patient; providing aqueous cavity information, such as collector channel resistance and Schlemm's canal resistance, and determining a treatment recommendation for the patient based on the aforementioned parameters.
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    19. Fluid infusion methods for glaucoma treatment

      The invention relates to methods of treating glaucoma, such as a method that includes inserting a stent through an incision in an eye; the stent having an inflow portion that is in fluid communication with an outflow portion of the stent; transporting the stent from the incision through the anterior chamber of the eye to an aqueous cavity of the eye, such that the inflow portion of the stent is positioned in the anterior chamber and the outflow portion of the stent is positioned at the aqueous cavity; and infusing fluid from the inflow portion to the outflow portion of ...
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    20. Optical coherence tomography on autologous translocation of choroid and retinal pigment epithelium in age-related macular degeneration

      Purpose To analyse structural changes after autologous translocation of choroid and retinal pigment epithelium (RPE) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT).Methods We performed a prospective nonrandomised study in 29 consecutive patients, who underwent submacular surgery with translocation of an autologous full-thickness graft of RPE, Bruch's membrane, and choroid. All patients had recent loss of reading vision due to AMD. OCT was performed before surgery and at 3- and 6- month follow-up to analyse the morphological appearance of the graft and the overlying retina.Results Maximum retinal thickness decreased from mean 408 m ...

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    21. Corneal and Anterior Segment Optical Coherence Tomography - Optovue (CAS-OCT)

      Device: OCT measurements Two OCT systems from Optovue Inc. (Fremont, CA) are used to perform preoperative scanning. The first OCT system is called RTVue. It is a FDA-approved Fourier-Domain OCT system. The second OCT sytem is call ACVue. It is an experimental Time-Domain OCT system and used to measure crystalline lens thickness and anterior chamber depth. The measurements from both OCT systems are used in selecting IOL power.
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    22. Methods, Systems And Computer Program For 3D-Registration Of Three Dimensional Data Sets Obtained By Preferably Optical Coherence Tomography Based On The Alignment Of Projection Images Or Fundus Images, Respectively (Wo 2007/016397)

      Methods of registration of three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified ...
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