1. Articles in category: Ophthalmology

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    1. Disruption of the Photoreceptor Inner Segment-Outer Segment Junction in Eyes With Macular Holes

      Purpose: To examine the relationship between visual acuity and morphologic characteristics of macular holes as determined using spectral domain optical coherence tomography (SD OCT). Methods: A retrospective analysis was performed of eyes with open and closed macular holes at a single, referral-based retina practice. The main outcome measures included best-corrected Snellen visual acuity and SD OCT findings, including the size of the macular hole and the disruption of the junction between inner segments (ISs) and outer segments (OSs) of the photoreceptors. Results: The mean visual acuity for eyes with open (n = 24) and closed (n = 17) macular holes was 20 ...
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    2. A review of in vivo animal studies in retinal prosthesis research

      Background The development of a functional retinal prosthesis for acquired blindness is a great challenge. Rapid progress in the field over the last 15 years would not have been possible without extensive animal experimentation pertaining to device design and fabrication, biocompatibility, stimulation parameters and functional responses. This paper presents an overview of in vivo animal research related to retinal prosthetics, and aims to summarize the relevant studies. Methods A Pubmed search of the English language literature was performed. The key search terms were: retinal implant, retinal prosthesis, artificial vision, rat, rabbit, cat, dog, sheep, pig, minipig. In addition a manual ...
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    3. Ultrasound provides clearer picture of posterior segment

      "Currently available ultrasound techniques can evaluate the cornea to the level of microns. By imaging the sulcus, ciliary body, and lens, the results are superior to OCT imaging," he said. "For retina specialists, this technology is useful for looking at the anterior segment, that is, the ciliary body and the area around the lens. This imaging approach is also useful to diagnose and follow patients with tumors to determine if treatment with an iodine or other radioactive plaque is necessary or, if used, was effective. However, the posterior segment cannot be visualized using high frequencies because of ultrasound absorption, thus ...
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    4. Spectral-domain optical coherence tomography an improvement over previous optical coherence tomography systems

      Spectral-domain optical coherence tomography (SD-OCT) offers several major advantages over conventional OCT: faster image acquisition time, improved resolution, and improved image processing. In addition, the technology decreases patient motion artifact, which is especially useful when obtaining images in children.
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    5. Automated system separates glaucomatous, healthy eyes

      An automated glaucoma risk indicator using digital color fundus photos proved to be accurate in the detection of glaucoma disease in a recent study. This novel technique is not intended to replace other state-of-the-art diagnostic techniques currently used . Ophthalmologists, however, can receive a confirmation from this automated diagnosing system that the diagnosis they are making in regards to glaucoma is the right one.
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    6. Fourier-domain optical coherence tomography allows improved visualization of retinal layers

      Sacramento, CA—Fourier-domain optical coherence tomography (OCT) is a new technology that enables improved visualization of the retinal layers, especially the photoreceptor layer. This technology, also known as spectral-domain OCT, is sensitive enough to facilitate the diagnosis of maculopathy in eyes with vision loss unexplained using routine diagnostic tests, such as funduscopy, fluorescein angiography, and time-domain OCT technology (Stratus OCT, Carl Zeiss Meditec). So says Susanna S. Park, MD, PhD, who with colleagues used for research a high-resolution Fourier-domain OCT instrument developed by the Vision Science and Advanced Retinal Imaging Laboratory at the University of California Davis. The system differs ...
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    7. Optical coherence tomography a useful addition to clinical practice, doctor finds

      A proprietary device for optical coherence tomography (Visante, Carl Zeiss Meditec) seems to be a highly useful addition to clinical practice. The instrument, according to one physician, may be the best resource thus far to evaluate placement of intracorneal segments, femtosecond laser-enabled keratoplasty, and penetrating keratoplasty.
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    8. 3-D optical coherence tomography gaining ground, but 2-D optical coherence tomography may be mainstay

      Three-dimensional optical coherence tomography (OCT) has improved on the speed with which scans are obtained and has added more detailed information about the retina in various retinal diseases. Two-dimensional OCT, however, should remain a staple in retinal practice for some time to come.
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    9. Spectral domain-optical coherence tomography produces better results of retinal nerve fiber thickness imaging than scanning laser polarimetry, study shows

      A recent study using a high-resolution spectral-domain optical coherence tomography (SD-OCT) to image and quantify retinal nerve fiber (RNF) loss in patients with glaucoma showed superior imaging results when compared with the imaging of a scanning laser polarimetry (SLP) device.
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    10. An Analysis of Normal Variations in Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography.

      Purpose: To assess the normal variations in retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). Subjects and Methods: Both eyes of 48 individuals (age 56.4+/-9.5 y) with normal vision and refractive errors between +/-6.0 D were tested with the fast RNFL scan protocol of the OCT3 (Zeiss Meditech). Their 256-point RNFL profiles were exported for analysis. The location and peak amplitude of the maxima of the RNFL profiles were measured. Intersubject and interocular variations were assessed with a coefficient of determination, R2. An R2 of 1.0 indicated that the average profile ...
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    11. Posterior Cystoid Retinal Degeneration in Central Serous Chorioretinopathy.

      Related Articles Posterior Cystoid Retinal Degeneration in Central Serous Chorioretinopathy. Retina. 2008 July/August;28(7):1008-1012 Authors: Piccolino FC, De La Longrais RR, Manea M, Cicinelli S PURPOSE:: To study the pattern of cystoid retinal changes in the posterior fundi of eyes with chronic central serous chorioretinopathy (CSC) using optical coherence tomography (OCT). METHODS:: We retrospectively studied 34 eyes with chronic CSC and cystoid retinal changes at the posterior pole documented by OCT. We analyzed the distribution of cystoid retinal changes with respect to the fovea and chorioretinal lesions. RESULTS:: Generally, cystoid retinal changes occurred in the papillomacular region ...
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    12. Features of Age-Related Macular Degeneration Assessed with 3-Dimensional-Fourier-Domain OCT

      Background/Aims: Age-related macular degeneration (AMD) is amongst the leading causes of severe visual loss in individuals over 60 years old. Retinal changes associated with AMD were previously studied by time-domain optical coherence tomography (OCT). Recently, Fourier-Domain OCT (FD-OCT) has been introduced. FD-OCT provides increased scan resolution, scanning speed and generates 3-dimensional OCT images. The purpose of this study was to demonstrate features of AMD assessed with high-density scanning 3d-FD-OCT (Topcon 3d-OCT1000). Methods: The study was designed as a prospective, observational case series. Five patients with typical morphological changes due to AMD were chosen based on funduscopic findings. Eyes with ...
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    13. Early Morphologic Changes and Functional Abnormalities in Group 2A Idiopathic Juxtafoveolar Retinal Telangiectasis Using Spectral Domain Optical Coherence Tomography and Microperimetry

      Aims: To report early morphologic changes and functional abnormalities in group 2A idiopathic juxtafoveolar retinal telangiectasis (IJRT) using spectral domain optical coherence tomography (SD-OCT) and microperimetry. Methods: Six eyes (three patients; average age, 64 years) with group 2A IJRT were examined using SD-OCT and microperimetry. Results: On SD-OCT, breaks in the highly reflective line, considered the boundary between the photoreceptor inner and outer segments, at the temporal to the fovea and corresponding to the telangiectasis lesions were observed in all eyes. Highly reflective tissue was observed in the outer retinal layer in five eyes. In three eyes with a right-angle ...
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    14. OTI received a warning letter in connection with a FDA

      On March 25, 2008, OTI received a warning letter in connection with a FDA inspection of OTI's facilities in July and August of 2007. The warning letter cited several deficiencies in OTI's quality, record keeping, and reporting systems relating to certain of OTI's products, including the OTI Scan 1000, OTI Scan 2000, and OTI OCT/SLO combination imaging system. Based upon the observations noted in the warning letter, OTI is not currently in compliance with cGMP. The FDA indicated that it has issued an Import Alert and may refuse admission of these products. As a result, we ...
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    15. Monte Carlo modeling of corneal and retinal Optical Coherence Tomography imaging

      Monte Carlo simulations of OCT images of cornea and retina was performed for various setup parameters. Several models of cornea and retina were implemented; the optical parameters or the model were chosen basing on the experimental results. Obtained simulated image exhibits qualitative agreement with the experimental ones allowing for preliminary numerical study of OCT technique for ocular structure and ophthalmologic diseases diagnostics.
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    16. Physical Sciences Inc. Adaptive Optics Spectral Domain Optical Coherence Tomography

      Physical Sciences Inc. Adaptive Optics Spectral Domain Optical Coherence Tomography
      The adaptive optics spectral domain optical coherence tomography (AO-SDOCT) system combines adaptive optics for detection and correction of ocular aberrations with high-speed SDOCT. The combination of AO for increased lateral resolution with high axial resolution low coherence interferometry allows micron-level resolution of retinal structures and layers.
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    17. Detection of the Optic Nerve Head Neural Canal Opening within Three-Dimensional Histomorphometric and Spectral Domain Optical Coherence Tomography Data Sets.

      Purpose: To assess the ability to detect the neural canal opening (NCO) and its characteristics within 3-D histomorphometric and 3-D spectral domain optical coherence tomography (SD-OCT) reconstructions of the optic nerve head from non-human primate (NHP) eyes. Methods: NCO was delineated within 40 radial, sagittal sections of 3-D histomorphometric reconstructions of 44 normal eyes of 38 NHPs, each perfusion-fixed at IOP 10 mmHg, and Heidelberg Spectralis 3-D SD-OCT volumes acquired in vivo from a separate group of 33 normal eyes of 24 NHPs. Within all reconstructions, a least-squares ellipse was fitted to the 80 NCO points. For each eye, the ...
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    18. Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration

      Background/Aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomic changes in eyes with non-neovascular age related macular degeneration (AMD) compared to time domain optical coherence tomography (TDOCT). Methods: Images were obtained from 3 eyes of 3 patients with AMD using an experimental SDOCT system. Both a Titanium-sapphire (Ti:Sapphire) laser and a superluminescent diode (SLD) was used as a broadband light source to achieve cross-sectional images of the retina. Qualitative and quantitative analysis was done of structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyze drusen size ...

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    19. Analysis of Macular Thickness in British Population Using Optical Coherence Tomography (oct): An Emphasis on Interocular Symmetry

      Purpose: To evaluate macular thickness measurements in normal subjects from British origin, to assess interocular asymmetry using optical coherence tomography (OCT) and to establish standard values for macular and foveal thickness. Methods: Two hundred eyes of 100 normal individuals underwent serial scans using fast macular thickness map protocol in the Stratus OCT version 3.51, with foveal fixation. Minimum foveal thickness (MFT), central 1 mm average foveal thickness (AFT), total foveal volume (TFV) and total macular volume (TMV at 6 mm) of both eyes were assessed. The interocular asymmetry was measured and statistically analyzed. Results: The mean ± SD (N = 200 ...

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