1. Articles in category: Ophthalmology

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    1. Advances in spectral domain 3-D high-resolution OCT

      Spectral domain optical coherence tomography (SD-OCT), the latest generation of the technology, is a breakthrough because it has dramatically cut the time required to obtain images by eliminating the moving mirror that was a component of standard OCT, according to Cynthia Toth, MD. In addition to being 50 times faster than conventional OCT, SD-OCT has improved resolution because of improved processing. Another benefit is decreased patient movement artifact, especially in pediatric patients. "In
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    2. Enhanced optical coherence tomography for anatomical mapping

      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...
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    3. Optovue Receives FDA Clearance for Cornea/Anterior Module for RTVue

      Fremont, CA — October 25, 2007 - Optovue, Inc., the first company to introduce a Fourier-domain optical coherence tomography (FD-OCT) system to the US market, today announced that on September 28, FDA 510(k) clearance was received for its Cornea/Anterior Module (CAM). The CAM is an optional attachment for the RTVue, Optovue’s high-speed and high-resolution FD-OCT device for retinal imaging. The CAM add-on enhances the RTVue by enabling five-micron resolution, high-magnification imaging of the co
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    4. Optical coherence tomography and disease subtype in multiple sclerosis

      Objective: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). Methods: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). Results: MS ON eyes had decreased RNFL thickness (84.2 µm) compared to controls (102.7 µm) (p p p p p ...
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    5. In vivo functional imaging of humancone photoreceptors

      We evaluate a novel non-invasive optical technique for observing fast physiological processes, in particular phototransduction, in single photoreceptor cells in the living human eye. The method takes advantage of the interference of multiple reflections within the outer segments (OS) of cones. ... [Opt. Express 15, 16141-16160 (2007)]

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    6. Use of a scanner to modulate spatial interferograms for in vivo full-range Fourier-domain optical coherence tomography

      Use of a scanner to modulate spatial interferograms for in vivo full-range Fourier-domain optical coherence tomography
      Lin An, Ruikang K. WangWe report a new yet simple method to achieve full-range complex Fourier-domain optical coherence tomography (OCT) for in vivo imaging. The method utilizes a scanner that is dedicated for lateral scanning in the system to introduce a constant carrier frequency into the OCT spectral interferograms ... [Opt. Lett. 32, 3423-3425 (2007)]
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    7. Optical coherence tomography and vessel diameter changes after intravitreal bevacizumab in diabetic macular oedema

      Purpose: To assess the effect of intravitreal bevacizumab on diabetic macular oedema (DMO) and retinal vessel calibres. Methods: We performed a consecutive case series study in which 10 consecutive eyes with diffuse DMO, two of which had not previously been treated, received an intravitreal injection of bevacizumab 1 mg, which was followed by two more injections at 6-week intervals. Fundus photography and optical coherence tomography (OCT) were carried out at baseline immediately before injection and at 1, 2.5 and 4 months after the first injection. Outcome measures were best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study ...

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    8. Eye scan helps detect multiple sclerosis

      Eye scan helps detect multiple sclerosis
      by MT Bureau - October 17, 2007 - 0 comments Baltimore -- U.S. researchers suggest an eye exam that takes five minutes could become an inexpensive and effective way to gauge and track multiple sclerosis, or MS. Baltimore -- U.S. researchers suggest an eye exam that takes five minutes could become an inexpensive and effective way to gauge and track multiple sclerosis, or MS. The study, published in Neurology, used optical coherence tomography to scan optic
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    9. Early detection of macular changes in patients with diabetes using Rarebit Fovea Test and optical coherence tomography

      Aim: To evaluate central retinal thickness and foveal function using optical coherence tomography (OCT) and the Rarebit Fovea Test (RFT) in patients with diabetes without previously known retinopathy or maculopathy. Method: Forty-two patients with diabetes mellitus (DM) were selected from the screening records at St Erik Eye Hospital. Inclusion criteria were absence of macular or other retinal changes at previous screening examination and best corrected visual acuity >=1.0. These patients and 42 healthy controls were examined with the recently developed RFT, and retinal thickness was measured using OCT. Lens thickness and light scatter were evaluated by Scheimpflug photography. Results ...
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    10. Association between integrity of foveal photoreceptor layer and visual acuity in branch retinal vein occlusion

      Aim: To study the correlation between integrity of the photoreceptor layer after resolution of macular oedema (MO) associated with branch retinal vein occlusion (BRVO) and final visual acuity (VA), and to determine prognostic factors for visual outcome. Methods: We retrospectively studied 46 eyes from 46 patients with resolved MO secondary to BRVO, the foveal thickness of which was less than 250 µm at final observation. We assessed the status of the third high reflectance band (HRB) in the fovea using optical coherence tomography (OCT) at final observation, and studied OCT images taken at the initial visit in the hope of ...
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    11. The characteristic features of optical coherence tomography in posterior uveitis

      Aim: To describe the different retinal morphological characteristics that can present on optical coherence topography (OCT) in a spectrum of uveitic diseases. Methods: We reviewed the literature and our own OCT image archive for characteristic features that may be suggestive of a particular disease process. Results: OCT demonstrates a variety of characteristic morphological changes, some that may point towards a specific disease process. We describe the various forms of macular oedema found in uveitis as well as OCT features typically found in multifocal choroiditis, serpiginous chorioretinitis, toxoplasma chorioretinitis, Vogt–Koyanagi–Harada, sympathetic ophthalmia and the vitreomacular traction syndrome. Conclusion: Ophthalmologists ...
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    12. Effect of pupillary dilatation on glaucoma assessments using optical coherence tomography

      Aims: To examine the effect of pupillary dilatation on the reliability of retinal nerve fibre layer (RNFL) and optic nerve head (ONH) assessments using Stratus OCT in a glaucoma clinic. Methods: Observational study of 38 patients attending a glaucoma clinic. The "fast optic disc" and "fast RNFL thickness" programs on Stratus OCT were used to measure the RNFL thickness and ONH cup to disc ratio (CDR). Two scans were done before dilatation and two after dilatation with tropicamide 1% drops. The mean values and reproducibility before and after dilatation were compared, along with the quality of scans as indicated by ...
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    13. OCT reveals vitreous abnormalities associated with optic disc pit ...

      Optical coherence tomography can be used to preoperatively identify various vitreal abnormalities associated with optic disc pit maculopathy, a study by researchers in Greece shows. The finding suggests that the abnormal vitreous likely contributes to the macular elevation seen in such patients, the authors noted. Panagiotis G. Theodossiadis, MD, and colleagues used optical coherence tomography (OCT) to examine the vitreous of 38 eyes in 38 patients aged 14 to 51 years. All patients had macular
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    14. Eye Scan May Help Diagnose, Treat MS

      MONDAY, Oct. 15 (HealthDay News) -- A short and simple eye scan not only appears capable of spotting multiple sclerosis earlier in the course of the disease, but might also provide a way to track progression of the illness, as well as the effectiveness new drugs in development, researchers say. "We're in the process of validating this for clinical utility," said Dr. Peter Calabresi, lead author of the study and director of the Johns Hopkins Multiple Sclero
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    15. The predictive value of optical coherence tomography after grid laser photocoagulation for diffuse diabetic macular oedema

      Purpose: To assess the predictive value of optical coherence tomography (OCT) mapping of retinal thickness and intraretinal morphological changes after macular grid for diffuse diabetic macular oedema (DMO). Methods: We carried out a prospective, non-controlled, case series study, in which 28 consecutive eyes with previously untreated diffuse DMO underwent fundus photography and OCT at baseline and at 1, 3 and 6 months after treatment. Results: Macular photocoagulation was followed by a significant reduction in retinal thickness in the foveal centre (− 80 μm) and in the foveal subfield (− 65 μm) from baseline to 6 months (p 0.05). The relative decrease ...

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    16. Photoreceptor Disruption Secondary to Posterior Vitreous Detachment as Visualized Using High-Speed Ultrahigh-Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has been shown to be beneficial in the diagnosis of posterior vitreous detachment (PVD) and vitreomacular traction. In 2001, ultrahigh-resolution OCT (UHR-OCT), capable of 3-μm axial resolution in the human eye, has demonstrated refined visualization of outer retinal layers.1Dramatic advances in the imaging speed of OCT enable high pixel density, high-definition imaging with further improved image quality.2 The following is a case of bilateral photoreceptor disruption secondary to PVD, imaged using high-speed UHR-OCT.

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    17. Eye Scan May Help Diagnose, Treat MS

      The inexpensive test could lead to new drugs, researchers add By Amanda Gardner Posted 10/15/07 MONDAY, Oct. 15 (HealthDay News) -- A short and simple eye scan not only appears capable of spotting multiple sclerosis earlier in the course of the disease, but might also provide a way to track progression of the illness, as well as the effectiveness new drugs in development, researchers say. Related News * Video: Health News & Features * Health Community * More
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    18. Doctor Gets Cutting Edge 3-D Gadget

      JESSE OSBOURNE/Highlands Today Optometric Assistant Alma Garcia demonstrates the new 3D Optical Coherence Tomography machine at the office of Sevigny & Johnson in Avon Park. By Jim Konkoly of Highlands Today Published: November 1, 2007 AVON PARK — For about four years, said Dr. Ron Sevigny, eye doctors have been awaiting development of a break-through technology that gives a much more detailed and three dimensional view of the retina. On Monday, that technol
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    19. Autofluorescence Of Orange Pigment Overlying Small Choroidal Melanoma.

      Orange pigment overlying small choroidal melanoma shows bright hyperautofluorescence, contrasting with isoautofluorescence of the underlying tumor.Page: 1107DOI: 10.1097/IAE.0b013e31814934efAuthors: SHIELDS, CAROL L. MD; BIANCIOTTO, CARLOS MD; PIRONDINI, CESARE MD; MATERIN, MIGUEL A. MD; HARMON, SARAH A. BS; SHIELDS, JERRY A. MD
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    20. Rebound Of Cystoid Macular Edema With Continued Use Of Acetazolamide In Patients With Retinitis Pigmentosa.

      Optical coherence tomography is more sensitive than fluorescein angiography for the detection and monitoring of cystoid macular edema during treatment with acetazolamide in patients with retinitis pigmentosa.Page: 1112DOI: 10.1097/IAE.0b013e31805f6b79Authors: APUSHKIN, MARSHA A. MD; FISHMAN, GERALD A. MD; GROVER, SANDEEP MD; JANOWICZ, MARK J. BA
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    21. Automatic retinal blood flow calculation using spectral domain optical coherence tomography

      Keywords (OCIS): (110.4500) Imaging systems : Optical coherence tomography (120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation (170.4580) Medical optics and biotechnology : Optical diagnostics for medicine Abstract Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed
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