1. Articles in category: Ophthalmology

    11689-11712 of 11777 « 1 2 ... 485 486 487 488 489 490 491 »
    1. MIT team takes high-res, 3-D images of eye

      MIT team takes high-res, 3-D images of eye
      In work that could improve diagnoses of many eye diseases, MIT researchers have developed a new type of laser for taking high-resolution, 3-D images of the retina, the part of the eye that converts light to electrical signals that travel to the brain. The research will be presented at the Conference on Lasers and Electro-Optics and the Quantum Electronics and Laser Science Conference in Baltimore on May 10.
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    2. Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography

      Purpose To compare the macular retinal thickness and macular volume between subjects with high myopia and non-myopia. Methods This prospective nonrandomized, comparative study recruited healthy subjects with high myopia subjects, defined as a spherical equivalence (SE) over - 6 dioptres (D) or AXL26.5 mm and the best corrected visual acuity better than 20/25, and subjects with non-myopia, defined as an with SE between 1.5D and - 1.5 D and the BCVA better than 20/25. Optical coherence tomography was performed in each eye. Results Eighty high myopic eyes and 40 non-myopic eyes were included. The mean age of ...
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    3. Optical Coherence Tomography of the Macula in Congenital Achromatopsia

      Optical Coherence Tomography of the Macula in Congenital Achromatopsia
      purpose. It is known that symptoms of congenital achromatopsia are caused by the lack of functioning cones, but there are very few published data on histologic changes in the retina in these cases. This study was conducted to examine in vivo the anatomic structure of the retina of patients with achromatopsia. methods. Fifteen eyes of eight patients with congenital achromatopsia and 18 eyes of nine control subjects were examined by optical coherence tomography. Radial 6-mm scans were taken of the macula. The thickness of the neuroretina was measured both automatically and manually. Measurements were taken at the foveola and at ...
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    4. Relation of optical coherence tomography and unusual angiographic leakage patterns in central serous chorioretinopathy

      Purpose To investigate the anatomic basis of atypical angiographic leaks in central serous chorioretinopathy (CSC) with optical coherence tomography (OCT). Methods Fluorescein angiography (FA) and OCT were performed in three eyes of three patients (two men, one woman) with CSC. The angiographic leaks were treated with transpupillary thermotherapy (TTT) in two patients with long-standing CSC. The investigations were repeated in the treated patients during follow-up visits. Results Clinically, all patients demonstrated typical CSC; the female patient had subretinal fibrin under the detachment. FA showed unusual leakage patterns and OCT revealed bridging tissue connecting the pigment epithelial detachment (PED) to the ...
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    5. Assessment of the posterior segment of the cat eye by optical coherence tomography (oct)

      Objectives To assess the feasibility of optical coherence tomography (OCT) for examining the cat ocular fundus, to provide normative data on retinal thickness in different fundus regions, and to demonstrate selected surgically induced vitreoretinal pathologies in the cat. Animal studied Forty-five eyes of 28 healthy domestic cats and two eyes of domestic cats that had undergone subretinal implantation surgery for a visual prosthesis were examined. Procedures An optical coherence tomograph (Zeiss-Humphrey) was used to examine the anesthetized animals. At least five vertical and five horizontal scans in regular distribution were recorded for each cat including (1) the peripapillary region, (2 ...
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    6. Optical coherence tomography in a patient with tobacco-alcohol amblyopia

      Aim To report optical coherence tomography (OCT) finding in a patient with tobacco-alcohol amblyopia. Methods A 45-year-old man presented with a gradual decrease in vision over 4 years. He had smoked a half to one pack of cigarettes per day and had consumed 350 cc of gin per day for 30 years. A detailed ophthalmologic examination was performed. Results His corrected visual acuities were 20/800 OD and 20/200 OS. A Goldmann visual field examination showed ceco-central scotomas in both eyes. OCT using a peripapillary Fast RNFL (retinal nerve fiber layer) programme showed a small decrease in the RNFL ...

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    7. Correlation between microaneurysm closure rate and reduction in macular thickness following laser photocoagulation of diabetic macular edema

      Aim To correlate the microaneurysmal closure rate measured on fundus fluorescein angiography (FFA) with reduction in macular thickness observed on optical coherence tomography (OCT) following laser photocoagulation of diabetic macular edema. Materials and methods A prospective observational case series. Fifty patients (50 eyes) of type II diabetes mellitus with clinically significant macular oedema (CSME) underwent focal/grid laser photocoagulation. OCT and FFA were performed at baseline and at 2 and 12 weeks following laser photocoagulation to measure the change in macular thickness and the number of leaking microaneurysms respectively. Statistical analysis was performed using paired-ttest and Pearson's correlation test ...
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      Mentions: Amod Gupta
    8. Step by Step Optical Coherence Tomography with Photo CD-ROM (Book)

      Step by Step Optical Coherence Tomography with Photo CD-ROM (Book)
      In "Step by Step OCT" we have endeavored to create a small book conveying only those things that would be important for the non-academic day to day user of OCT. A total of 25 chapters cover all aspects of the subject. Interprets OCT procedures in a simple and user-friendly manner. Describes various disease patterns with typical examples. Emphasizes macular, retinal and optic nerve head diseases. Summarizes important points in the tables and boxes. Useful equally to the students as well as ophthalmologist either in training or in practice.
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    9. Optovue, an ocular disease treatment co., raises $10.5M

      Optovue, a Fremont, Ca. maker of devices that improve diagnosis and treatment of ocular disease, has received $10.5 million in second round of funding, the company announced said. Based on high speed and high resolution Fourier-Domain OCT technology, the products help with retina conditions such as macular degeneration, diabetic retinopathy, glaucoma, and other macular diseases. Trevi Health Ventures led the round, which also included Acorn Campus Ventures, HNQ Asia Pacific, Harbinger Venture Management, iD SoftCapital and other individual investors. Optovue raised about $4.5 million in a first round
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      Mentions: Optovue Jay Wei
    10. Optovue raises $10.5M

      Ophthalmic device maker Optovue Corp. said Friday it received $10.5 million in second-round funding. Fremont-based Optovue said New York-based Trevi Health Ventures led the investment, followed by several partners from Optovue's previous funding round. The company said the money will be used to expand production of the its RTVue device, which was recently released outside the United States, as well as advance development of the company's product pipeline. Optovue also appointed John Moore, forme
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    11. Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy

      Aim: A comparison of retinal thickness (RT) measurements with optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (DM) and no or minimal diabetic retinopathy (DR) versus healthy controls. Methods: Fifty-three patients with type 1 DM with no or minimal DR underwent full ophthalmic examination, fundus photography and OCT. Mean RT measured by OCT was calculated for the central fovea, the fovea, the pericentral and the peripheral area of the macula, and compared to healthy controls. Results: Mean RT in the pericentral area was lower in patients with minimal DR (267 µm ± 20 µm; n = 23) compared to ...

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    12. Targeted stent placement and multi-stent therapy

      A trabecular flow model for producing treatment recommendations for patients with elevated intraocular pressure is disclosed. One method includes providing intraocular pressure measurements for a patient; providing aqueous cavity information, such as collector channel resistance and Schlemm's canal resistance, and determining a treatment recommendation for the patient based on the aforementioned parameters.
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    13. Fluid infusion methods for glaucoma treatment

      The invention relates to methods of treating glaucoma, such as a method that includes inserting a stent through an incision in an eye; the stent having an inflow portion that is in fluid communication with an outflow portion of the stent; transporting the stent from the incision through the anterior chamber of the eye to an aqueous cavity of the eye, such that the inflow portion of the stent is positioned in the anterior chamber and the outflow portion of the stent is positioned at the aqueous cavity; and infusing fluid from the inflow portion to the outflow portion of ...
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    14. Optical coherence tomography on autologous translocation of choroid and retinal pigment epithelium in age-related macular degeneration

      Purpose To analyse structural changes after autologous translocation of choroid and retinal pigment epithelium (RPE) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT).Methods We performed a prospective nonrandomised study in 29 consecutive patients, who underwent submacular surgery with translocation of an autologous full-thickness graft of RPE, Bruch's membrane, and choroid. All patients had recent loss of reading vision due to AMD. OCT was performed before surgery and at 3- and 6- month follow-up to analyse the morphological appearance of the graft and the overlying retina.Results Maximum retinal thickness decreased from mean 408 m ...

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    15. Corneal and Anterior Segment Optical Coherence Tomography - Optovue (CAS-OCT)

      Device: OCT measurements Two OCT systems from Optovue Inc. (Fremont, CA) are used to perform preoperative scanning. The first OCT system is called RTVue. It is a FDA-approved Fourier-Domain OCT system. The second OCT sytem is call ACVue. It is an experimental Time-Domain OCT system and used to measure crystalline lens thickness and anterior chamber depth. The measurements from both OCT systems are used in selecting IOL power.
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    16. Methods, Systems And Computer Program For 3D-Registration Of Three Dimensional Data Sets Obtained By Preferably Optical Coherence Tomography Based On The Alignment Of Projection Images Or Fundus Images, Respectively (Wo 2007/016397)

      Methods of registration of three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified ...
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    17. High-speed imaging of human retina in vivo with swept-source optical coherence tomography

      We present the first demonstration of human retinal imaging in vivo using optical frequency domain imaging (OFDI) in the 800-nm range. With 460-μW incident power on the eye, the sensitivity is 91 dB at maximum and >85 dB over 2-mm depth range. The axial resolution is 13 μm in air. We acquired images of retina at 43,200 depth profiles per second and a continuous acquisition speed of 84 frames/s (512 A-lines per frame) could be maintained over more than 2 seconds.
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    18. Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

      The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 μm where most likely single scattering of light occurs in cornea. It is shown that ...
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    19. Evaluation of peripapillary detachment in pathologic myopia with en face optical coherence tomography

      Background A newly recognized lesion in pathologic myopia is peripapillary detachment of the retinal pigment epithelium (RPE) and retina. Recently introduced en face optical coherence tomography (OCT) provides not only cross-sectional but also coronal scans of the retina, and allows lateral extent visualization and thickness measurement of lesions. Methods Three patients presenting bilateral peripapillary yellow-orange lobulated area in high myopia have been evaluated with fluorescein angiography (FA), indocyanine green angiography (ICGA), en face OCT (OCT/SLO; Ophthalmic Technologies Inc, Toronto, Canada), and Humphrey visual field analyzer. Results In all eyes, en face OCT has shown the presence of a peripapillary ...
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    20. Iris recognition and tracking for optical treatment

      A system and method are provided in which an iris or eye image is taken during a refractive diagnostic analysis. The image is employed for aligning data from the analysis with data from other refractive analysis instruments, as well as aligning a refractive surgical tool, such as a laser, with the eye for treatment. Further, the stored iris image is compared with the patient's iris before treatment, verifying that the correct eye is to be treated with a developed treatment pattern. A variety of refractive instruments can be used, such as corneal topography systems and wavefront aberration systems.
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    21. Optical apparatus and method for comprehensive eye diagnosis

      An eye examination instrument is presented that can perform multiple eye tests. The instrument includes an illumination optical path and an imaging optical path, wherein a focus element in the illumination optical path is mechanically coupled to a focus element in the imaging optical path. In some embodiments, the eye examination instrument can perform a visual eye test, a fundus imaging test, and an optical coherence tomography test.
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      Mentions: Optovue Jay Wei Nidek
    22. Integrated scanning and ocular tomography system and method

      Systems and methods of the present invention measure at least one reflecting surface of an object disposed along an optical path. In some embodiments a measured optical interference signal for each of at least three wavelengths of reflected light may be used to determine a modulation of frequency components of a Fourier series. Frequency components of a Fourier series may be transformed to spatial components that describe intensities and positions of light reflected along an optical path.Systems and methods of the present invention permit rapid measuring and may monitor corneal thickness during surgery. The invention may do so by ...
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    23. System and method for predictive ophthalmic correction

      A system and method for providing a predictive outcome in the form of a predictive best instruction for a therapeutic ophthalmic correction of a patient's vision defects. The predictive best instruction is derived from prospective therapeutic-outcome-influencing, new information that is analyzed in conjunction with optimized, historical therapeutic-outcome information. The instruction is preferably an optimized, custom, photoablative algorithm for driving a photoablative, excimer laser. The instruction can be provided on a fee basis.
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      Mentions: Bausch & Lomb
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