1. Articles in category: Ophthalmology

    11281-11304 of 12085 « 1 2 ... 468 469 470 471 472 473 474 ... 502 503 504 »

    1. Spectral Domain Optical Coherence Tomographic Findings of Occult Macular Dystrophy

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      Occult macular dystrophy is a rare macular disorder in which patients have bilaterally decreased visual acuity without any significant ophthalmoscopic findings. Using spectral domain optical coherence tomography, the authors found a defect in the junction between the inner and outer segments of the foveal photoreceptors in a patient with occult macular dystrophy. [Ophthalmic Surg Lasers Imaging 2008;39:S114-S116.]
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      Mentions: Hideki Koizumi LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    2. Spectral Domain Optical Coherence Tomography in a Patient With Adult-onset Vitelliform Dystrophy Treated With Intravitreal Bevacizumab

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      A patient with adult-onset vitelliform dystrophy received intravitreal injections of bevacizumab in one eye. During 4 months of follow-up, spectral domain optical coherence tomography (SD-OCT) showed a progressive decrease of yellowish deposits and complete resolution of subretinal fluid at the last follow-up. Despite the good anatomic outcome, the patient reported a mild decrease in visual acuity and persistent metamorphopsia. The clinical course and the correlation between the fundus findings and the morphologic information from SD-OCT data are described. [Ophthalmic Surg Lasers Imaging 2008;39:S111-S113.]
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      Mentions: Asan Medical Center University of Ulsan

    3. Spectral Domain Optical Coherence Tomography and Fundus Autofluorescence Findings in Pseudoxanthoma Elasticum

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      A 39-year-old man with pseudoxanthoma elasticum who had a loss of vision was examined using digital imaging. Spectral domain optical coherence tomography (SD-OCT) detected subfoveal deposits that coincided with hyperautofluorescent areas on fundus autofluorescence imaging. These deposits seemed to cause the patient’s rapid visual loss because no angioid streaks or choroidal neovascularization were present in the fovea. These deposits were not observed on fundus and infrared photography. SD-OCT combined with fundus autofluorescence imaging may be a useful tool for diagnosis of the atypical deposits in patients with pseudoxanthoma elasticum, which could lead to visual loss. [Ophthalmic Surg Lasers Imaging ...
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      Mentions: Heidelberg Engineering Cleveland Clinic Carl Zeiss Meditec

    4. Selected Clinical Comparisons of Spectral Domain and Time Domain Optical Coherence Tomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      The authors report four cases where spectral domain optical coherence tomography (SD-OCT) imaged pathology not captured by time domain optical coherence tomography (TD-OCT). These cases include one of angioid streaks, two of juxtafoveal telangiectasia, and one of age-related macular degeneration. In each case, the improved images provided by SD-OCT changed either the management of the patient or the counseling of their disease process. [Ophthalmic Surg Lasers Imaging 2008;39:S104-S107.]
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      Mentions: Heidelberg Engineering

    5. Composite Spectral Domain Optical Coherence Tomography Images of Diabetic Tractional Retinal Detachment

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      This article describes the spectral domain optical coherence tomography (SD-OCT) findings in three patients with diabetic tractional retinal detachment. Three patients underwent fundus photography and SD-OCT imaging before and after pars plana vitrectomy, endolaser, and membrane peel. On SD-OCT, all three patients exhibited significant improvement or resolution of subretinal fluid after the surgical release of traction. In this case series, a clinically useful method of visualizing SD-OCT images is demonstrated. Composite images were manually constructed with commercially available software by merging high-density B-scans from the macula and optic nerve. The composite image allowed simultaneous visualization of the effects of proliferative ...
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      Mentions: Giovanni Gregori Carl Zeiss Meditec University of Miami

    6. Imaging Serpiginous Choroidopathy With Spectral Domain Optical Coherence Tomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      The use of spectral domain optical coherence tomography (SD-OCT) in the study of chronic serpiginous choroiditis was evaluated. Two patients with chronic serpiginous choroiditis were imaged using two prototype SD-OCT systems (6-µm axial resolution). Raster scans covering 6 × 6 × 2-mm regions of the retina were obtained, enabling the study of different retinal cross-sectional images. Thickness maps were obtained after segmentation of retinal layers, which could be compared with those on follow-up. SD-OCT allowed the visualization of the cross-sectional retinal architecture at different horizontal positions. Superimposition of SD-OCT generated reconstructed fundus images with fundus photographs provided accurate images registration. Segmentation of ...
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      Mentions: Giovanni Gregori Carmen A. Puliafito Philip J. Rosenfeld

    7. Myopic Traction Maculopathy: Spectral Domain Optical Coherence Tomographic Imaging and a Hypothesized Mechanism

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      A patient with progressive visual loss and macular hole development due to progressive myopic traction maculopathy was studied using spectral domain optical coherence tomography (SD-OCT). A characteristic, deep retinal schisis-like change was clearly demonstrable. Progression to a full-thickness macular hole was documented. Postoperatively, the macular hole was closed, and the visual acuity was restored. SD-OCT imaging allowed better resolution of macular features but requires evaluation of all scan data. The source of progressive inner retinal traction may be the posterior extension of the staphyloma. [Ophthalmic Surg Lasers Imaging 2008;39:S90-S94.]
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      Mentions: Giovanni Gregori University of Miami Yonsei University

    8. Three-dimensional Visualization of Vitreoretinal Abnormalities in High Myopia

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      The authors have evaluated with three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) four highly myopic eyes (2 patients) presenting with peripapillary detachment of the pigment epithelium (PDPM), vitreoretinal tractions, and myopic retinoschisis. Three-dimensional SD-OCT analysis of PDPM revealed an optically empty space localized beneath the retinal pigment epithelium (RPE). A peripapillary separation of the retina-RPE complex from the choroid could explain the presence of this space. The 3D imaging of vitreomacular tractions could help physicians plan the appropriate surgical approach in patients with myopic posterior detachment due to macular hole. [Ophthalmic Surg Lasers Imaging 2008;39:S86-S89.]
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      Mentions: University Federico II

    9. Fuchs’ Endothelial Dystrophy in 830-nm Spectral Domain Optical Coherence Tomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      This article presents for the first time the potential of 830-nm spectral domain optical coherence tomography (SD-OCT) in the evaluation of Fuchs’ endothelial dystrophy. SD-OCT is an imaging technique that can be used for in vivo cross-sectional corneal visualization. The important features of SD-OCT instruments include improved sensitivity and short acquisition time, which improves the quality of the tomograms compared with conventional time domain OCT. Tomograms of the corneas of three patients in different stages of Fuchs’ endothelial dystrophy are presented. The authors conclude that 830-nm SDOCT provides clinically valuable cross-sectional assessment of pathomorphological changes in Fuchs’ endothelial dystrophy in ...
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      Mentions: Maciej Wojtkowski Nicolaus Copernicus University Andrzej A. Kowalczyk

    10. Correlation of Fourier Domain Optical Coherence Tomography Retinal Nerve Fiber Layer Maps With Visual Fields in Nonarteritic Ischemic Optic Neuropathy

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE To correlate peripapillary retinal nerve fiber layer (NFL) loss and visual field defects in nonarteritic ischemic optic neuropathy (NAION). PATIENTS AND METHODS Patients with NAION and control subjects were enrolled in a case–control study. Participants were scanned with a Fourier domain optical coherence tomography (OCT) system. Peripapillary NFL thickness was averaged in hemispheric, quadrant, and octant divisions. Standard achromatic static perimetry was used to assess visual fields. RESULTS The reproducibility of peripapillary NFL parameters was excellent in both the healthy and NAION groups. Eyes in the NAION group showed a significant decrease of peripapillary NFL thickness ...
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      Mentions: Optovue David Huang University of Southern California

    11. Comparison of Spectral Domain Optical Coherence Tomography and Color Photographic Imaging of the Optic Nerve Head in Management of Glaucoma

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE Spectral domain optical coherence tomography (SD-OCT) allows three-dimensional imaging of the optic disc. The objective of this study was to compare optic disc and cup margins between fundus photographs and SD-OCT. PATIENTS AND METHODS Eighteen eyes with glaucoma were examined by a custom-built SD-OCT. OCT fundus images were used to register fundus photographs and SD-OCT volume. RESULTS Disc margins on fundus photographs corresponded to termination of the highly reflective straight line that represented the retinal pigment epithelium (RPE) or the highly reflective curved line that connected to the RPE on the OCT B-scan images at 99.3 ...
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      Mentions: Topcon Medical Systems Masanori Hangai Yoshiaki Yasuno

    12. Retinal Angiomatous Proliferation: Morphological Changes Assessed by Stratus and Cirrus OCT

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology

      BACKGROUND AND OBJECTIVESpectral domain optical coherence tomography (SD-OCT) should be used to examine lesions containing retinal angiomatous proliferation (RAP) to achieve a better understanding of the origin of this pathology.PATIENTS AND METHODSIn this prospective, observational case series, patients with RAP underwent retinal thickness imaging with Stratus OCT and cube 200 × 200 imaging with Cirrus OCT.RESULTSA total of 12 eyes from 11 patients were included in the study. Of these, eight eyes had stage III RAP and four eyes had stage II RAP. Cirrus OCT detected the hyperrefl ective area corresponding to the neovascularization in all 12 eyes and ...

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      Mentions: Carl Zeiss Meditec Susanne Binder Ludwig Boltzmann Institute

    13. Spectral Domain High-definition Optical Coherence Tomography in Patients Undergoing Epiretinal Membrane Surgery

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology

      BACKGROUND AND OBJECTIVETo evaluate possible advantages of spectral domain optical coherence tomography (SD-OCT) in epiretinal membranes.PATIENTS AND METHODSPatients with idiopathic epiretinal membranes (ERMs) were examined before and after vitreoretinal surgery. Cirrus SD high definition (HD)-OCT was compared with Stratus time domain OCT to find correlations with visual acuity (VA) and metamorphopsia. RESULTS Five consecutive patients were enrolled. With Cirrus HD-OCT, it was possible to differentiate between the ERM and the retinal surface in all patients. In areas where the ERM was adherent, this differentiation was severely limited with Stratus OCT. We found no significant correlations between Cirrus OCT ...

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      Mentions: Carl Zeiss Meditec Susanne Binder Ludwig Boltzmann Institute

    14. Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE Knowledge of the macular thickness in a normal population is important for the evaluation of pathological macular change. The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT). PATIENTS AND METHODS Fifty eyes from 50 normal subjects (29 men and 21 women, aged 22 to 68 years) were scanned with a prototype Cirrus HD-OCT system (5 µm axial resolution) (Carl Zeiss Meditec, Inc.). The proprietary Cirrus segmentation algorithm was used to produce retinal thickness maps, which were then averaged over 9 regions defined by a ...
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      Mentions: Giovanni Gregori Carmen A. Puliafito University of Southern California

    15. Comparison of Macular Thickness Between Cirrus HD-OCT and Stratus OCT

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE To compare macular thicknesses in healthy subjects measured with spectral domain optical coherence tomography (SD-OCT) (Cirrus; Carl Zeiss Meditec, Inc., Dublin, CA) with measurements using time domain (TDOCT) (Stratus; Carl Zeiss Meditec, Inc.). PATIENTS AND METHODS Macular thickness was measured five times in the same eye of 10 healthy subjects with both Cirrus and Stratus to assess reliability and then once in the same eye of 50 healthy subjects with both Cirrus and Stratus to compare the average obtained by each device. RESULTS Using TD-OCT, the coefficient of variations (CV) of the macular thicknesses within a 1-mm ...
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      Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT Zeiss Stratus OCT

    16. Analysis of the Outer Retina Reconstructed by High-resolution, Three-dimensional Spectral Domain Optical Coherence Tomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE A retrospective cross-sectional study was conducted to demonstrate an analysis of an outer retinal layer reconstructed by the three-dimensional and high-speed spectral domain optical coherence tomography (SD-OCT) instrument. PATIENTS AND METHODS New measurement protocols for SD-OCT and methods of analysis and visualization of the individual segmented retinal layer reconstructed by SD-OCT were proposed. Three contour maps representing mutual distances between the basal part of the retinal pigment epithelium, the junction between the inner and outer segments of photoreceptors, and a reference contour representing the shape of a healthy retina were introduced. RESULTS The analysis of the outer ...
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      Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

    17. Calibration of Fundus Images Using Spectral Domain Optical Coherence Tomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE Measurements performed on fundus images using current software are not accurate. Accurate measurements can be obtained only by calibrating a fundus camera using measurements between fixed retinal landmarks, such as the dimensions of the optic nerve, or by relying on a calibrated model eye provided by a reading center. However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image. PATIENTS AND METHODS The ability to measure exact distances on SD-OCT fundus images was tested by measuring the distance between the center of the fovea and the optic nerve ...
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      Mentions: Giovanni Gregori University of Wisconsin Carmen A. Puliafito

    18. Advantages of Using a Ray-traced, Three-dimensional Rendering System for Spectral Domain Cirrus HD-OCT to Visualize Subtle Structures of the Vitreoretinal Interface

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology

      BACKGROUND AND OBJECTIVETo create a ray-traced, three-dimensional display system for Cirrus high-definition optical coherence tomography (Carl Zeiss Meditec, Inc., Dublin, CA) that improves the visualization of subtle structures of the vitreoretinal interface.PATIENTS AND METHODSHigh-definition optical coherence tomography (HD-OCT) data for epiretinal membranes (17 eyes), macular holes (11 eyes), and posterior vitreal detachments (17 eyes) were collected. A display system that visualizes the acquired data using ray-tracing algorithms was designed and compared with the Cirrus HD-OCT 2.0 advanced visualization software system. The area around the vitreoretinal interface was visualized using a 100-µm-thick internal limiting membrane (ILM) fi tted slab ...

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      Mentions: Carl Zeiss Meditec Susanne Binder Ludwig Boltzmann Institute

    19. Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      BACKGROUND AND OBJECTIVE To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using auto fluorescence (FAF). PATIENTS AND METHODS Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. RESULTS GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference ...
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      Mentions: Giovanni Gregori Carmen A. Puliafito Philip J. Rosenfeld

    20. Geometric Deformable Model Driven by CoCRFs: Application to Optical Coherence Tomography

      Explore SpringerLink Home Ophthalmology
      We present a geometric deformable model driven by dynamically updated probability fields. The shape is defined with the signed distance function, and the internal (smoothness) energy consists of a C 1 continuity constraint, a shape prior, and a term that forces the zero-level of the shape distance function towards a connected form. The image probability fields are estimated by our collaborative Conditional Random Field (CoCRF), which is updated during the evolution in an active learning manner: it infers class posteriors in pixels or regions with feature ambiguities by assessing the joint appearance of neighboring sites and using the classification confidence ...
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      Mentions: Giovanni Gregori Philip J. Rosenfeld University of Miami

    21. The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT)

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration and glaucoma. Laser Doppler velocimetry (LDV), a noninvasive optical method combined with vessel size determination has been used extensively as a valuable research tool to examine blood flow dynamics in the human retina. However, no information on the velocity profile within the vessel is available. Ophthalmic color Doppler optical coherence tomography (CDOCT) provides laser Doppler information in addition to conventional optical coherence tomography, allowing the observation of blood flow dynamics simultaneously to imaging retinal structure. We have ...
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      Mentions: Medical University of Vienna

    22. Multifocal VEP and OCT in optic neuritis: a topographical study of the structure–function relationship

      Explore SpringerLink Home Ophthalmology
      Abstract Purpose To investigate topographical relationship between amplitude of multifocal visual evoked potentials (mfVEP) and retinal nerve fibre layer (RNFL) thickness following acute optic neuritis (ON). Patients and Methods Fifty patients with a clinical diagnosis of acute unilateral ON between 6 and 36 months prior to the study and 25 age-matched controls underwent mfVEP testing (Accumap V 2.1, ObjectiVision Pty Ltd, Sydney, Australia) and OCT imaging (fast RNFL protocol, Stratus™, software version 3.0, Carl Zeiss Meditec, Inc., Dublin, CA). RNFL thickness and mfVEP amplitude were measured for upper, temporal and lower retinal sectors and corresponding areas of the ...
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      Mentions: Carl Zeiss Meditec University of Sydney Zeiss Stratus OCT

    23. Macular Hole Surgery With Air Tamponade And Optical Coherence Tomography-Based Duration Of Face-Down Positioning.

      Explore RETINA Ophthalmology
      Air tamponade and face-down positioning for 1 to 3 days led to macular hole closure in 90.9% of cases. The duration of face-down positioning was based on postoperative optical coherence tomography imaging of the status of macular hole closure through the air tamponade using a special optical coherence tomography technique.Page: 1087DOI: 10.1097/IAE.0b013e318185fb5fAuthors: ECKARDT, CLAUS MD; ECKERT, TILLMANN MD; ECKARDT, UTE MD; PORKERT, UTE MD; GESSER, CAROLINE MD
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    24. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis

      Explore Archives of Neurology, a monthly peer Neurology , Ophthalmology

      Background  Optical coherence tomography (OCT) is a promising new method of quantifying axon thickness in the retinal nerve fiber layer (RNFL) that has been used predominantly by ophthalmologists to monitor glaucoma. Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers.Objective  To determine the reproducibility of OCT measurement of mean RNFL thickness in the undilated eyes of healthy control subjects and patients with MS.Design  Prospective analysis of 4 healthy controls to determine interrater, intrarater, and longitudinal reproducibility. Cross-sectional ...

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      Mentions: Peter A. Calabresi Johns Hopkins University University of Alabama
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