1. Articles in category: Ophthalmology

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    1. The predictive value of optical coherence tomography after grid laser photocoagulation for diffuse diabetic macular oedema

      Explore Blackwell Synergy Ophthalmology

      Purpose: To assess the predictive value of optical coherence tomography (OCT) mapping of retinal thickness and intraretinal morphological changes after macular grid for diffuse diabetic macular oedema (DMO). Methods: We carried out a prospective, non-controlled, case series study, in which 28 consecutive eyes with previously untreated diffuse DMO underwent fundus photography and OCT at baseline and at 1, 3 and 6 months after treatment. Results: Macular photocoagulation was followed by a significant reduction in retinal thickness in the foveal centre (− 80 μm) and in the foveal subfield (− 65 μm) from baseline to 6 months (p 0.05). The relative decrease ...

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      Mentions: University of Copenhagen Michael Larsen Birgit Sander

    2. Photoreceptor Disruption Secondary to Posterior Vitreous Detachment as Visualized Using High-Speed Ultrahigh-Resolution Optical Coherence Tomography

      Explore Archives of Ophthalmology Ophthalmology

      Optical coherence tomography (OCT) has been shown to be beneficial in the diagnosis of posterior vitreous detachment (PVD) and vitreomacular traction. In 2001, ultrahigh-resolution OCT (UHR-OCT), capable of 3-μm axial resolution in the human eye, has demonstrated refined visualization of outer retinal layers.1Dramatic advances in the imaging speed of OCT enable high pixel density, high-definition imaging with further improved image quality.2 The following is a case of bilateral photoreceptor disruption secondary to PVD, imaged using high-speed UHR-OCT.

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      Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

    3. Eye Scan May Help Diagnose, Treat MS

      Explore health.usnews.com Neurology , Ophthalmology
      The inexpensive test could lead to new drugs, researchers add By Amanda Gardner Posted 10/15/07 MONDAY, Oct. 15 (HealthDay News) -- A short and simple eye scan not only appears capable of spotting multiple sclerosis earlier in the course of the disease, but might also provide a way to track progression of the illness, as well as the effectiveness new drugs in development, researchers say. Related News * Video: Health News & Features * Health Community * More
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      Mentions: Patricia O'Looney Johns Hopkins University

    4. Doctor Gets Cutting Edge 3-D Gadget

      Explore Latest stories Ophthalmology
      JESSE OSBOURNE/Highlands Today Optometric Assistant Alma Garcia demonstrates the new 3D Optical Coherence Tomography machine at the office of Sevigny & Johnson in Avon Park. By Jim Konkoly of Highlands Today Published: November 1, 2007 AVON PARK — For about four years, said Dr. Ron Sevigny, eye doctors have been awaiting development of a break-through technology that gives a much more detailed and three dimensional view of the retina. On Monday, that technol
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      Mentions: Topcon Medical Systems University of Miami

    6. Autofluorescence Of Orange Pigment Overlying Small Choroidal Melanoma.

      Explore RETINA Ophthalmology
      Orange pigment overlying small choroidal melanoma shows bright hyperautofluorescence, contrasting with isoautofluorescence of the underlying tumor.Page: 1107DOI: 10.1097/IAE.0b013e31814934efAuthors: SHIELDS, CAROL L. MD; BIANCIOTTO, CARLOS MD; PIRONDINI, CESARE MD; MATERIN, MIGUEL A. MD; HARMON, SARAH A. BS; SHIELDS, JERRY A. MD
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      Mentions: Thomas Jefferson University Jerry A. Shields Miguel A. Materin

    7. Rebound Of Cystoid Macular Edema With Continued Use Of Acetazolamide In Patients With Retinitis Pigmentosa.

      Explore RETINA Ophthalmology
      Optical coherence tomography is more sensitive than fluorescein angiography for the detection and monitoring of cystoid macular edema during treatment with acetazolamide in patients with retinitis pigmentosa.Page: 1112DOI: 10.1097/IAE.0b013e31805f6b79Authors: APUSHKIN, MARSHA A. MD; FISHMAN, GERALD A. MD; GROVER, SANDEEP MD; JANOWICZ, MARK J. BA
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      Mentions: University of Florida Sandeep Grover

    8. Automatic retinal blood flow calculation using spectral domain optical coherence tomography

      Explore opticsinfobase.org Ophthalmology
      Keywords (OCIS): (110.4500) Imaging systems : Optical coherence tomography (120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation (170.4580) Medical optics and biotechnology : Optical diagnostics for medicine Abstract Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed
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      Mentions: Marco B. Ruggeri Giovanni Gregori Hassan M. Wehbe

    10. Corneal Imaging with Anterior Segment Optical Coherence Tomography for Lamellar Keratoplasty Procedures

      Explore ScienceDirect Ophthalmology
      Ten eyes of eight patients with pathologies involving the corneal stroma and sparing the Descemet membrane (DM) were included in this study conducted at a tertiary care hospital. The indications for DALK included corneal clouding attributable to mucopolysaccharidoses (n = 2), macular corneal dystrophy (n = 5), lattice corneal dystrophy (n = 1), granular corneal dystrophy (n = 1), and stromal scar attributable to infectious keratitis (n = 1). DALK was performed using the big-bubble technique in o
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      Mentions: Singapore Eye Research Institute Carl Zeiss Meditec National University of Singapore

    12. Changes in diabetic macular oedema after phacoemulsification surgery

      Explore Nature Publishing Group Ophthalmology
      Purpose To quantitatively examine changes in macular oedema after phacoemulsification surgery in eyes with diabetic retinopathy (DR) and in eyes without DR. Methods Thirty-four eyes with DR and 34 eyes with no DR scheduled for phacoemulsification surgery were recruited. Foveal thickness and macular volume were measured using optical coherence tomography preoperatively and at 3, 6, and 12 months postoperatively. Grade of diabetic macular oedema was also examined. Results Preoperatively, there were no significant differences between groups in foveal thickness and macular volume. The foveal thickness increased by 20.3% in the DR group and by 6.0% in the no ...
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    13. Optical Coherence Tomography versus Stereoscopic Fundus Photography or Biomicroscopy for Diagnosing Diabetic Macular Edema: A Systematic Review

      Explore iovs.org Ophthalmology

      PURPOSE. To review systematically the sensitivity and specificity of optical coherence tomography (OCT) for diagnosing macular edema attributable to diabetic retinopathy compared with well-established gold standard tests such as fundus stereophotography or contact and noncontact fundus biomicroscopy. METHODS. Medline and Embase were searched electronically and six major ophthalmic journals from 1998 to 2006 were hand searched. Two reviewers independently assessed trial searches, studied quality with the QUADAS (Quality Assessment of Diagnostic Accuracy Studies) checklist, and extracted data. The target disease was clinically significant macular edema (CSME) according to Early Treatment of Diabetic Retinopathy Study (ETDRS) criteria. A bivariate model was ...

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      Mentions: Francesco Bandello

    14. A Comparison of Macular Structure Imaged by Optical Coherence Tomography in Preterm and Full-Term Children

      Explore iovs.org Ophthalmology
      purpose. Macular anatomic abnormalities were examined by optical coherence tomography (OCT) imaging in premature children and compared with those of full-term children. methods. In a prospective case–control study, premature patients 7 to 14 years of age were divided into three groups (group I, laser-treated retinopathy of prematurity [ROP]; group II, spontaneously regressed ROP; group III, no ROP), and age-matched children (group IV). All the eligible 74 eyes had normal-appearing posterior pole, myopia ≤3 D, and best corrected visual acuity 1.0. When both eyes of a subject were eligible for the study, one eye was randomly selected (10 eyes ...
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    15. Optical Coherence Tomography for Multiple Sclerosis

      Explore GeneRef Neurology , Ophthalmology
      * A group of investigators from Johns Hopkins studied 40 multiple sclerosis (MS) patients with optical coherence tomography (OCT) of the eye (see flashbacks below about the technology), and found that this technique offers a potentially new, cost-effecti... ... Medgadget, Thursday, October 18, 2007 © 2007 SpaceRef Interactive Inc. All rights reserved
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      Mentions: Johns Hopkins University

    16. Retreatment of full-thickness macular hole: predictive value of optical coherence tomography

      Explore BJO Online Ophthalmology
      Aim: To determine whether the efficacy of re-operation for idiopathic full-thickness macular hole (FTMH) remaining open after initial surgery with internal limiting membrane (ILM) peeling is correlated with macular hole configuration as determined by optical coherence tomography (OCT), macular hole size, macular hole duration before the first operation, or type of tamponade (gas or silicone oil). Methods: A retrospective consecutive interventional case series of 28 patients (28 eyes) with a persisting macular hole after vitrectomy, ILM peel, and gas tamponade. 28 patients underwent repeat surgery involving vitrectomy and gas (n = 15) or silicone oil tamponade (n = 12) or no tamponade ...
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      Mentions: Carsten Framme

    17. Changes in anterior segment morphology in response to illumination and after laser iridotomy in Asian eyes: an anterior segment OCT study

      Explore BJO Online Ophthalmology

      Aim: Using the anterior segment optical coherence tomography (AS-OCT) to quantify changes in anterior segment morphology going from light to dark and following laser iridotomy (LI). Methods: Prospective observational study. 17 consecutive subjects without peripheral anterior synechiae undergoing LI were evaluated using gonioscopy and AS-OCT. Angle configuration including angle opening distance (AOD) at 500 microns anterior to the scleral spur, AOD500, trabecular-iris space area up to 750 microns from the scleral spur, TISA750 and the increase in angle opening going from dark to light conditions was determined. Results: Both mean AOD500 and TISA750 increased nearly threefold going from dark to ...

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      Mentions: Johns Hopkins University David Huang Cleveland Clinic

    18. Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography

      Explore BJO Online Ophthalmology
      Aim: To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography. Methods: Twenty-five normal subjects were invited for anterior chamber angle imaging with an anterior segment optical coherence tomography (OCT) on one randomly selected eye in three separate visits within a week. Each eye was imaged three times under room light (light intensity = 368 lux) and three times in the dark during the first visit. In the subsequent visits, each eye was imaged once in the light and once in the dark. The angle opening distance (AOD 500) and the trabecular–iris ...
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      Mentions: Chris K. S. Leung UCSD Robert N. Weinreb

    19. Tear dynamics measured with optical coherence tomography

      Explore uspto.gov Ophthalmology , Patents
      A system and method are provided for measuring the thickness of a tear film layer and the heights of tear menisci around upper and lower eyelids of an eye. A plurality of images are acquired between consecutive blinks the eye using optical coherence tomography (OCT). The images depict the tear film layer and tear menisci as distinct from the cornea of the eye. In an embodiment, a plurality of reflectivity profiles from an OCT image are aligned and averaged. The difference between a first peak and a second peak of the average reflectivity profile is measured to determine the thickness ...
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      Mentions: Jianhua Wang University of Miami

    20. High efficiency low coherence interferometry

      Explore uspto.gov Microscopy , Ophthalmology , Patents
      In accordance with the present invention, embodiments of interferometers are presented that improves both the polarization dependency problem and helps prevents light from being reflected back into the light source, among other things. Interferometer embodiments can include an isolator coupled to a light source and polarization dependent optics coupled with the isolator to provide light to a reference arm and a sample arm, wherein reflected light provided to optical detectors is such that a polarization independent optical signal can be formed in an optical signal processor coupled to the optical detectors, and the isolator blocks reflected light from the reference ...
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      Mentions: Optovue Jay Wei

    22. Comparison of macular hole size measured by optical coherence tomography, digital photography, and clinical examination

      Explore Nature Publishing Group Ophthalmology
      Aim To report on the agreement of macular hole size as measured using optical coherence tomography (OCT), Topcon digital photography, and surgeon estimate on clinical examination. Methods Observational cohort series of patients who underwent macular hole surgery over an 18-month period. Patients had OCT scan and digital fundus photographs preoperatively. At operation the surgeon estimated the size of macular hole. The agreement between methods was assessed using the technique described by Bland and Altman. Results There was good repeatability of photographic and OCT assessment and no evidence of systematic bias between repeated macular hole measurement by digital photography (P=0 ...
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    23. Medical device and methods of use for glaucoma treatment

      Explore uspto.gov Ophthalmology , Patents
      The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
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    24. Polypoidal choroidal vasculopathy examined with en face optical coherence tomography

      Explore Blackwell Synergy Ophthalmology
      Background: To study the morphologic features of polypoidal choroidal vasculopathy (PCV) with the use of en face optical coherence tomography (OCT). Methods: We reviewed retrospectively 57 eyes of 57 patients with PCV. The macular region was examined with OCT en face planes scanned at different sequential depths, following which detailed scanning was performed of arbitrarily selected longitudinal planes. Results: In 48 of the cases (84.2%), en face OCT allowed us to detect round protrusions of the retinal pigment epithelium (RPE) that corresponded to the polypoidal lesions seen on indocyanine green angiography (ICGA); the branching vascular networks seen on ICGA ...
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      Mentions: Nagahisa Yoshimura Akitaka Tsujikawa Kyoto University Graduate School of Medicine
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