1. Articles in category: Ophthalmology

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    1. Retinal nerve fiber layer thickness measurements using optical coherence tomography in migraine patients

      Purpose: To compare the retinal nerve fiber layer thickness (RNFL) in eyes of migraine patients with age-matched healthy subjects using optical coherence tomography. Methods: The study was designed as an observational cross-sectional study. 70 eyes of 70 patients (mean age 28.2 +/- 7.9 years) with migraine with or without aura according to the criteria of the Headache International Society (HIS) and 53 eyes of 53 age-matched healthy controls (mean age 28.0 +/- 8.1 years) were included. OCT was performed with the Stratus OCT (model 3000, software ver. 4.0.2; Carl Zeiss Meditec, Dublin, CA) after pupillary dilation ...
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    2. Correlation of Spectral Optical Coherence Tomography with Fluorescein and Indocyanine Green Angiography in Multiple Evanescent White Dot Syndrome

      Aims: To determine spatial location of lesions in Multiple Evanescent White Dot Syndrome (MEWDS) with the aid of spectral optical coherence topography (SOCT), fluorescein angiography (FA) and indocyanine green angiography (ICGA). Methods: A novel method of three-dimensional SOCT data analysis called reflectivity maps was introduced. The reflectivity maps display the distribution of a back-reflected intensity taken only from individual retinal layers located at specific distance from the reference plane. Reflectivity maps of the inner retina, the junction between photoreceptor inner and outer segments (IS/OS), retinal pigment epithelium and choroid of the patient with MEWDS were created and correlated with ...
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    3. Retinal Nerve Fiber Layer Measures in High- and Normal-Tension Glaucoma.

      Retinal Nerve Fiber Layer Measures in High- and Normal-Tension Glaucoma. Optom Vis Sci. 2008 Jul;85(7):538-542 Authors: Konstantakopoulou E, Reeves BC, Fenerty C, Harper RA PURPOSE.: To use optical coherence tomography (OCT) to investigate the qualitative and quantitative differences in the defects of the retinal nerve fiber layer (RNFL) in subjects with high tension primary open angle glaucoma and subjects with normal tension glaucoma. METHODS.: RNFL was assessed with OCT in 21 eyes with high-tension glaucoma (HTG) and 20 eyes with normal-tension glaucoma (NTG). Regression analyses were performed to investigate the interaction of disease group and location for ...
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    4. Juxtafoveolar Telangiectasis Associated with Crest Syndrome

      Purpose: To report a case of CREST syndrome associated with juxtafoveolar telangiectasias (JT). Design: Case report. Methods: Observational case report. Results: A 64-year-old woman affected with CREST syndrome developed bilateral visual loss. Capillary dilatation and permeability changes in the outer retina were noticed during an angiographic study. Optical coherence tomography (OCT) showed thickening with loss of the foveal depression and inner lamellar cyst. The patient was diagnosed as stage 3, group 2A JT associated with CREST syndrome. Conclusions: Finding JT in association with CREST syndrome suggests a common pathophysiologic process.
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    5. The relationship between Rarebit perimetry and OCT-derived retinal nerve fibre layer thickness in glaucoma

      Purpose: To examine the association between measures of neuroretinal matrix integrity as determined with Rarebit perimetry and optical coherence tomography (OCT)-derived retinal nerve fibre layer thickness.Methods: One randomly selected eye of 30 White primary open-angle glaucoma patients (age: 60.9 ± 11.7 years; MD: [minus]3.2 ± 5.1 dB) and 16 healthy White individuals (age: 33.2 ± 6.4 years; MD: [minus]0.8 ± 0.8 dB) were included in the study. Participants underwent Rarebit perimetry testing (central field, software version 4) and an OCT fast retinal nerve fibre layer (RNFL) scan. Correlation was investigated between hemifield ...
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    6. Myopic foveoschisis: Vitrectomy beneficial before macular hole development

      Detecting a macular hole or photoreceptor detachment is critical for obtaining good surgical results in patients with myopic foveoschisis. Patients with the foveal detachment type seem to benefit the most from vitrectomy. Spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) are valuable for managing these patients, said Yasushi Ikuno, MD, Osaka University Medical School, Osaka, Japan.
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    7. Optometric referrals to retina specialists: evaluation and triage via teleophthalmology.

      Optometric referrals to retina specialists: evaluation and triage via teleophthalmology. Telemed J E Health. 2008 Jun;14(5):441-5 Authors: Hanson C, Tennant MT, Rudnisky CJ A retrospective noncomparative consecutive case series was conducted to evaluate the clinical outcomes of a novel teleophthalmology program linking optometrists to retina specialists in Alberta, Canada. One hundred seventy-one patients, referred by optometrists via teleophthalmology to a group retina practice between June 2004 and May 2006 underwent stereoscopic, mydriatic digital photography. Images were transmitted to a secure Web server and analyzed by a retina specialist. Diagnosis and recommendations were sent back to the optometrist ...

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    8. Comparison of the Optical Coherence Tomographic Features of Choroidal Neovascular Membranes in Pathologic Myopia versus Age-Related Macular Degeneration, using Quantitative Subanalysis

      Aim: To compare the retinal morphologic characteristics of eyes with choroidal neovascularization (CNV) secondary to pathologic myopia versus eyes with CNV secondary to age-related macular degeneration (AMD), using quantitative optical coherence tomography (OCT) subanalysis.Methods: Twenty-one eyes of 21 patients newly diagnosed with CNV secondary to pathologic myopia, and 43 consecutive cases of eyes with newly diagnosed subfoveal CNV secondary to AMD were retrospectively collected. In all patients, StratusOCT images and fluorescein angiograms (FA) were available for analysis. StratusOCT images were analyzed using custom software (termed "OCTOR"), which allowed calculation of the thickness/volume of the neurosensory retina, subretinal fluid ...

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    9. Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal.

      Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal. Acta Ophthalmol. 2008 Jun 17; Authors: Hougaard JL, Heijl A, Bengtsson B Purpose: We aimed to compare the retinal nerve fibre layer (RNFL) in different Stratus optical coherence tomography (OCT) images in glaucoma eyes with RNFL thickness values within normal limits. Methods: We studied the Stratus OCT high-resolution standard protocol for assessment of peripapillary RNFL thickness. The four glaucoma eyes presented (with reproducible visual field defects, mean deviations from - 3.49 dB to - 0.49 dB and structural loss on RNFL and/or disc ...
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    10. Uveitic macular oedema: correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography.

      Uveitic macular oedema: correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography. Br J Ophthalmol. 2008 Jul;92(7):922-7 Authors: Tran TH, de Smet MD, Bodaghi B, Fardeau C, Cassoux N, Lehoang P AIMS: (1) To associate optical coherence tomography (OCT) patterns with particular fluorescein angiography (FA) findings in uveitis patients with macular oedema. (2) To investigate the correlation between tomographic features and visual acuity (VA). (3) To determine the impact of OCT patterns on visual improvement over time. METHODS: 129 eyes of 90 patients followed for uveitis with macular oedema and adequate media clarity were ...
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    11. Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

      Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized ...

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    12. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis.

      Background Studying axonal loss in the retina is a promising biomarker for multiple sclerosis (MS). Our aim was to compare optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) techniques to measure the thickness of the retinal nerve fiber layer (RNFL) in patients with MS, and to explore the relationship between changes in the RNFL thickness with physical and cognitive disability. We studied 52 patients with MS and 18 proportionally matched controls by performing neurological examination, neuropsychological evaluation using the Brief Repetitive Battery-Neuropsychology and RNFL thickness measurement using OCT and HRT. Results We found that both OCT and HRT could ...
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    13. Quantitative Subanalysis of Optical Coherence Tomography after Treatment with Ranibizumab for Neovascular Age-Related Macular Degeneration

      PURPOSE. To investigate the effects of ranibizumab on retinal morphology in patients with neovascular age-related macular degeneration (AMD) using optical coherence tomography (OCT) quantitative subanalysis. METHODS. Data from 95 patients receiving intravitreal ranibizumab for neovascular AMD were collected. StratusOCT images were analyzed using custom software that allows precise positioning of prespecified boundaries on every B-scan. Changes in thickness/volume of the retina, subretinal fluid (SRF), subretinal tissue (SRT), and pigment epithelial detachments (PEDs) at week 1 and at months 1, 3, 6, and 9 after treatment were calculated. RESULTS. Total retinal volume reached its nadir at month 1, with an ...

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    14. Mapping Standard Automated Perimetry to the Peripapillary Retinal Nerve Fiber Layer in Glaucoma

      purpose. To establish a map relating visual field (VF) test points to corresponding areas of the retinal nerve fiber layer (RNFL) measured with optical coherence tomography (OCT) in patients with glaucomatous optic neuropathy.methods. One hundred four consecutive subjects with open-angle glaucoma were prospectively selected. All subjects underwent standard automated perimetry (SAP) and imaging with OCT. Factor analyses of the mean thresholds for the SAP test points were performed, independently for each hemifield, to define regions of related points. Pearson correlations were then calculated between the VF regions and peripapillary RNFL thickness measured with OCT at each of the 12 ...

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    15. Morphologic Changes in Patients with Geographic Atrophy Assessed with a Novel Spectral OCT-SLO Combination

      purpose. To investigate the appearance of geographic atrophy in high-resolution optical coherence tomography (OCT) images, the fundus autofluorescence (FAF) pattern, and infrared images simultaneously recorded with a novel combined OCT-scanning laser ophthalmology (SLO) system. methods. Patients aged over 50 years with geographic atrophy secondary to dry age-related macular degeneration (ARMD) were assessed in a prospective cross-sectional study by means of simultaneous spectral OCT-SLO (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany). The integrity of the retinal layers was analyzed in the apparently normal areas, the junctional zone between the normal retina and the geographic atrophy, and the atrophic area. The presence ...

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    16. Evidence of Retinal Function Using Microperimetry following Autologous Retinal Pigment Epithelium-Choroid Graft in Macular Dystrophy

      purpose. To describe the outcomes of autologous retinal pigment epithelium (RPE)-choroid graft in macular dystrophy. methods. In this prospective interventional case series, five patients with macular dystrophy were enrolled to undergo autologous RPE-choroid patch graft between August 2005 and January 2007. All patients received preoperative and postoperative evaluations including visual acuity, contrast sensitivity, reading ability, microperimetry, fluorescein angiography, indocyanine green angiography, fundus autofluorescence (AF) imaging, and optical coherence tomography (OCT). results. Patients were followed up for an average of 13.4 (9–23) months. Two patients gained reading acuity but only one regained visual task function after graft. This ...

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      Mentions: Fred K. Chen
    17. Meridional differences in internal dimensions of the anterior segment in human eyes evaluated with 2 imaging systems.

      PURPOSE: To evaluate meridional differences in angle-to-angle (A-A) and sulcus-to-sulcus (S-S) dimensions in human eyes using very high frequency ultrasound (VHF US) and anterior segment optical coherence tomography (AS-OCT). SETTING: John A. Moran Eye Center, University of Utah, USA; Berlin Eye Research Institute, Germany; Quattroelle Centri Oftalmochirurgici, Italy. METHODS: Human autopsy eyes were fixated to special eye holders and had anterior segment scanning using 50 MHz ultrasound (Artemis, Ultralink) (20 eyes) and AS-OCT (SL-OCT, Heidelberg Engineering) (24 eyes). Seventy-three eyes (58 patients) also had anterior segment scanning using the same systems (Artemis, 50 eyes; SL-OCT, 23 eyes). Four meridians were ...
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    18. Uveitic macular oedema: correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography

      Aims: (1) To associate optical coherence tomography (OCT) patterns with particular fluorescein angiography (FA) findings in uveitis patients with macular oedema. (2) To investigate the correlation between tomographic features and visual acuity (VA). (3) To determine the impact of OCT patterns on visual improvement over time. Methods: 129 eyes of 90 patients followed for uveitis with macular oedema and adequate media clarity were consecutively included from February to November 2004. We examined the relationship between VA, the fluorescein angiograms grading and central thickness. Results: Mean retinal thickness at the central fovea was 357 (SD 128) µm. The mean VA was ...
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    19. Optical coherence tomography: limits of the retinal-mapping program in age-related macular degeneration

      Aim: The retinal-mapping program of Stratus optical coherence tomography (Carl Zeiss Meditec, Dublin, CA, USA) calculates the retinal volume of the central region between the retinal surface and the retinal pigment epithelium (RPE). This study evaluates the retinal-mapping program for studies dealing with AMD. Methods: The scans of both eyes of patients examined from August to October 2006 because of macular degeneration were evaluated retrospectively. Independent examiners tested whether the two lines indicating the retinal surface and the RPE were positioned correctly by the threshold algorithm that corresponded with correct measurements. Results: The scans of 233 eyes of 117 patients ...
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    20. Comparison of Optical Coherence Tomography Retinal Thickness Measurements in Diabetic Macular Edema with and without Reading Center Manual Grading from a Clinical Trials Perspective.

      Title: Comparison of Optical Coherence Tomography Retinal Thickness Measurements in Diabetic Macular Edema with and without Reading Center Manual Grading from a Clinical Trials Perspective. Invest Ophthalmol Vis Sci. 2008 Jun 19; Authors: Glassman AR, Beck RW, Browning DJ, Danis RP, Kollman C Purpose: To analyze the value of reading center error correction in automated Optical Coherence Tomography (OCT) retinal thickness measurements in eyes with diabetic macular edema (DME). Methods: 6,522 Zeiss Stratus OCT scans obtained in 7 DRCR.net studies were analyzed. The Reading Center evaluated whether the automated center point measurement appeared correct, and when not, it ...
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