1. Articles in category: Ophthalmology

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    1. Methods, Systems And Computer Program For 3D-Registration Of Three Dimensional Data Sets Obtained By Preferably Optical Coherence Tomography Based On The Alignment Of Projection Images Or Fundus Images, Respectively (Wo 2007/016397)

      Methods of registration of three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified ...
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    2. High-speed imaging of human retina in vivo with swept-source optical coherence tomography

      We present the first demonstration of human retinal imaging in vivo using optical frequency domain imaging (OFDI) in the 800-nm range. With 460-μW incident power on the eye, the sensitivity is 91 dB at maximum and >85 dB over 2-mm depth range. The axial resolution is 13 μm in air. We acquired images of retina at 43,200 depth profiles per second and a continuous acquisition speed of 84 frames/s (512 A-lines per frame) could be maintained over more than 2 seconds.
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    3. Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

      The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 μm where most likely single scattering of light occurs in cornea. It is shown that ...
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    4. Evaluation of peripapillary detachment in pathologic myopia with en face optical coherence tomography

      Background A newly recognized lesion in pathologic myopia is peripapillary detachment of the retinal pigment epithelium (RPE) and retina. Recently introduced en face optical coherence tomography (OCT) provides not only cross-sectional but also coronal scans of the retina, and allows lateral extent visualization and thickness measurement of lesions. Methods Three patients presenting bilateral peripapillary yellow-orange lobulated area in high myopia have been evaluated with fluorescein angiography (FA), indocyanine green angiography (ICGA), en face OCT (OCT/SLO; Ophthalmic Technologies Inc, Toronto, Canada), and Humphrey visual field analyzer. Results In all eyes, en face OCT has shown the presence of a peripapillary ...
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    5. Iris recognition and tracking for optical treatment

      A system and method are provided in which an iris or eye image is taken during a refractive diagnostic analysis. The image is employed for aligning data from the analysis with data from other refractive analysis instruments, as well as aligning a refractive surgical tool, such as a laser, with the eye for treatment. Further, the stored iris image is compared with the patient's iris before treatment, verifying that the correct eye is to be treated with a developed treatment pattern. A variety of refractive instruments can be used, such as corneal topography systems and wavefront aberration systems.
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    6. Optical apparatus and method for comprehensive eye diagnosis

      An eye examination instrument is presented that can perform multiple eye tests. The instrument includes an illumination optical path and an imaging optical path, wherein a focus element in the illumination optical path is mechanically coupled to a focus element in the imaging optical path. In some embodiments, the eye examination instrument can perform a visual eye test, a fundus imaging test, and an optical coherence tomography test.
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      Mentions: Optovue Jay Wei Nidek
    7. Integrated scanning and ocular tomography system and method

      Systems and methods of the present invention measure at least one reflecting surface of an object disposed along an optical path. In some embodiments a measured optical interference signal for each of at least three wavelengths of reflected light may be used to determine a modulation of frequency components of a Fourier series. Frequency components of a Fourier series may be transformed to spatial components that describe intensities and positions of light reflected along an optical path.Systems and methods of the present invention permit rapid measuring and may monitor corneal thickness during surgery. The invention may do so by ...
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    8. System and method for predictive ophthalmic correction

      A system and method for providing a predictive outcome in the form of a predictive best instruction for a therapeutic ophthalmic correction of a patient's vision defects. The predictive best instruction is derived from prospective therapeutic-outcome-influencing, new information that is analyzed in conjunction with optimized, historical therapeutic-outcome information. The instruction is preferably an optimized, custom, photoablative algorithm for driving a photoablative, excimer laser. The instruction can be provided on a fee basis.
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      Mentions: Bausch & Lomb
    9. Everyday OCT: A Handbook for Clinicians and Technicians (Book)

      Everyday OCT: A Handbook for Clinicians and Technicians (Book)
      Authorities on OCT technology and imaging, Dr. Joel S. Schuman, Dr. Carmen A. Puliafito, and Dr. James G. Fujimoto review OCT and provide both the beginning and advanced user with expert pearls on how to effectively perform and interpret OCT imaging. Everyday OCT contains a wealth of technical information about the principles of operating the Stratus OCTTM and the main components of this medical diagnostic imaging technology. Everyday OCT explains how to: Set up and employ OCT technology Select and facilitate scans Ensure and assess the quality of scans Accurately interpret OCT images Additional Features: Over 200 color images Tips ...
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    10. Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

      Purpose To determine macular sensitivity and fixation characteristics in patients with unilateral resolved central serous chorioretinopathy (CSC) using fundus-related microperimetry. Methods We reviewed 15 eyes with resolved CSC and 15 normal healthy eyes that had undergone fundus-related microperimetry. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, MP-1. The best-corrected visual acuity (VA) (BCVA), mean retinal sensitivity in the central 10° (central microperimetry, cMP-1) and in the paracentral 10–20° (paracentral microperimetry, pMP-1), and fixation stability and location were determined and compared with measurements in control eyes. Results BCVA at the time of this study was 20/20 ...
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    11. Medical device and methods of use of glaucoma treatment

      The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
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    12. System for measuring the optical image quality of an eye in a contactless manner

      A system is used for contactless measurement of the optical imaging quality of an eye with an interferometer by which at least one light pulse with a short coherence length is coupled into the eye from a light source. The optical path length of at least one arm of the interferometer is varied for measuring the length of the eye until a typical interference pattern between a reflection of the cornea and a reflection of the retina of the eye occurs in a detector. This interference pattern together with a known path segment of the variation of the optical path ...
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    13. In vivo measurements of macular and nerve fibre layer thickness in retinal arterial occlusion

      Aim To investigate the structure–function relationship in patients with retinal arterial occlusion by measuring the macular and the peripapillary retinal nerve fibre layer (RNFL) thickness and the visual sensitivity. Methods This is an observational case series with three patients with central retinal arterial occlusion (CRAO) and two patients with branch retinal arterial occlusion (BRAO). The macular/peripapillary RNFL thickness and the visual field were measured with Stratus optical coherence tomography (OCT) and Humphrey visual field analyzer, respectively, at least 1 year after the diagnosis of CRAO or BRAO. Results The macular thickness, in particular the inner retinal layer, and ...
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    14. Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation

      Purpose Cataract surgery is known to elicit postoperative macular oedema owing to its traumatic effect. The aim of the study was to measure the foveal and perifoveal thickness of the retina after uneventful phacoemulsification and posterior chamber intraocular lens (PC-IOL) implantation. Methods Retinal thickness values of the foveal and perifoveal (fovea+3.0 mm, fovea+6.0 mm) sectors and the minimum values were measured in a prospective study using optical coherence tomography (OCT) in 71 eyes of 71 patients (34 men, 37 women, mean age: 68.8 years) who underwent cataract surgery. Phacoemulsification and 'in the bag' implantation of ...
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    15. Optical frequency domain imaging of human retina and choroid (Thesis)

      Optical frequency domain imaging of human retina and choroid (Thesis)
      Optical coherence tomography (OCT) has emerged as a practical noninvasive technology for imaging the microstructure of the human eye in vivo. Using optical interferometry to spatially-resolve backreflections from within tissue, this high-resolution technique provides cross-sectional images of the anterior and posterior eye segments that had previously only been possible with histology. Current commercially-available OCT systems suffer limitations in speed and sensitivity, preventing them from effective screening of the retina and having a larger impact on the clinical environment. While other technological advances have addressed this problem, they are inadequate for imaging the choroid, which can be useful for evaluating choroidal ...
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    16. Optical Coherence Tomography For The Screening of Donor Corneas and Examination of the Retinal Nerve Fiber Directional Reflectance (Thesis)

      Optical Coherence Tomography For The Screening of Donor Corneas and Examination of the Retinal Nerve Fiber Directional Reflectance (Thesis)
      Optical coherence tomography (OCT) is a high resolution, non-invasive imaging technology that employs light to create detailed images of the body. In medicine, OCT is most widely used in ophthalmology to create high resolution images of the cornea and the retina. The group index of cornea, rather than phase refractive index, is required for thickness calculations with optical coherence tomography (OCT). Recent advances with high speed OCT at 1.3 m make index measurement at this wavelength of great interest. Group indices of 3 human eye bank corneas were measured in vitro using optical low-coherence reflectometry. Measurements were made in ...
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    17. Implant with pressure sensor for glaucoma treatment

      A trabecular shunt and methods for treating glaucoma are disclosed. One of the methods comprises transporting fluid from the anterior chamber of an eye to Schlemm's canal through an implant, the implant extending between the anterior chamber and Schlemm's canal; sensing an intraocular pressure using a sensor incorporated into the implant; and transmitting a signal indicative of the sensed pressure to an external receiver.
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    18. Automated detection of retinal layer structures on optical coherence tomography images

      Automated detection of retinal layer structures on optical coherence tomography images
      Segmentation of retinal layers from OCT images is fundamental to diagnose the progress of retinal diseases. In this study we show that the retinal layers can be automatically and/or interactively located with good accuracy with the aid of local coherence information of the retinal structure. OCT images are processed using the ideas of texture analysis by means of the structure tensor combined with complex diffusion filtering. Experimental results indicate that our proposed novel approach has good performance in speckle noise removal, enhancement and segmentation of the various cellular layers of the retina using the STRATUSOCTTM system.
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    19. Novel Diagnostics With Optical Coherence Tomography: Retinal Imaging

      The purpose of this research is to evaluate optical coherence tomography (OCT) and FDA approved device used to image diseases of the eye. The ultra-high resolution OCT is a non-significant risk device used in this study. Optical Coherence Tomography may be useful for early diagnosis and monitoring of different types of eye diseases.
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    20. Method and apparatus for improving vision and the resolution of retinal images

      A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which ...

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    21. System and method for evaluating a secondary Lasik treatment

      A method and system are disclosed for evaluating the safety of a prospective secondary LASIK treatment to correct a person's vision. The difficulties with making an accurate, direct measurement of corneal thickness of a cornea having a pre-existing keratectomy are overcome by using pre-LASIK topography and pachymetry measurements, and per- and post-LASIK wavefront measurements to determine post-LASIK corneal thickness, and thus the suitability and safety of a prospective secondary LASIK procedure. A system embodiment includes diagnostic and computing platforms for generating and analyzing data, and a device readable medium for storing and transferring an instruction to a laser ablation ...
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      Mentions: Bausch & Lomb
    22. Device and method for monitoring aqueous flow within the eye

      The present invention provides a device and method for monitoring the flow of aqueous humor within the eye. The invention provides that the aqueous flow rate and/or pattern within the anatomical structures of the eye can be determined by monitoring a traceable component. Such determination provides diagnostic indications of the degree and location of ocular disease associated with aqueous outflow, such as glaucoma, and can further provide post-treatment indications of effectiveness.
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