1. Articles in category: Ophthalmology

    11065-11088 of 11751 « 1 2 ... 459 460 461 462 463 464 465 ... 488 489 490 »
    1. Anterior segment OCT useful in preop, postop evaluations of refractive surgery patients

      Anterior segment OCT useful in preop, postop evaluations of refractive surgery patients
      Introduction Amar Agarwal Optical coherence tomography is a technique that uses light to create a two-dimensional cross-section image of the eye. This technique allows for imaging of either the anterior segment or the posterior segment. Decision-making for refractive surgery is aided by evaluations in either the preoperative or postoperative stages. My special guests in this column are Amin Ashrafzadeh, MD, and Roger F. Steinert, MD, who discuss the Visante anterior segment OCT in evaluation of patients being considered for excimer laser treatment. Amar Agarwal, MS, FRCS, FRCOphth OSN Complications Consult Editor Optical coherence tomography is a non-contact, real-time technique that ...
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    2. Anterior Chamber Angle Measurement with Anterior Segment Optical Coherence Tomography: A Comparison between Slit Lamp OCT and Visante OCT

      PURPOSE. To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility. METHODS. Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each subject and measured by two independent observers. The angle-opening distance (AOD 500), the trabecular–iris angle (TIA 500), and the trabecular–iris space area (TISA 500) at the nasal and ...
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    3. Effects of laser irradiation on collagen organization in chemically induced degenerative annulus fibrosus of lumbar intervertebral disc.

      Related Articles Effects of laser irradiation on collagen organization in chemically induced degenerative annulus fibrosus of lumbar intervertebral disc. Lasers Surg Med. 2008 Jul 22;40(6):422-432 Authors: Ignatieva N, Zakharkina O, Andreeva I, Sobol E, Kamensky V, Lunin V BACKGROUND AND OBJECTIVE: The number of in vitro experimental studies was carried out with the use of intact tissues to establish a mechanism of laser-tissue interaction. However, in the process of degeneration, both biochemical composition and behavior of the disc were altered drastically. The objective of this study was to evaluate the role of the main matrix components in ...
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    4. Effect of Soft Contact Lenses on Optical Measurements of Axial Length and Keratometry for Biometry in Eyes with Corneal Irregularities

      purpose. To assess the repeatability and reliability of IOLMaster (Carl Zeiss Meditec, Inc., Dublin, CA) axial length and keratometry measurements (K readings) with a soft contact lens on normal eyes. The method is designed for eyes with corneal irregularities or after endothelial keratoplasty. methods. Biometry was performed on 20 healthy right eyes of volunteer subjects with mean age, 27.3 ± 4.9 years; axial length, 24.77 ± 1.04 mm; and K reading, 43.48 ± 1.69 D. Axial length and keratometry were measured and repeated with –0.5 D SofLens38 (Bausch & Lomb, Rochester, NY) and Acuvue2 (Johnson & Johnson, New ...
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    5. Retinal Nerve Fiber Layer Analysis in RP Patients Using Fourier-Domain OCT

      purpose. To determine peripapillary retinal nerve fiber layer thickness (RNFL) abnormalities in patients with retinitis pigmentosa (RP) using Fourier-domain optical coherence tomography (Fd-OCT) and to evaluate the potential effect of cystoid macular edema (CME) or axial length on RNFL measurements in such patients. methods. Ninety-seven eyes of 52 patients with diagnoses of retinitis pigmentosa or Usher syndrome type II underwent complete ocular examination. Peripapillary RNFL thickness was measured using Fd-OCT in 16 segments from 4 quadrants—temporal (316°-45°), superior (46°-135°), nasal (136°-225°), and inferior (226°-315°). These measurements were compared with age- and disc size-adjusted control values ...
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    6. Differential Optical Densities of Intraretinal Spaces

      purpose. To test the hypothesis that hyporeflective spaces in the neuroretina found on optical coherence tomography (OCT) examination have different optical reflectivities according to whether they are associated with exudation or degeneration. methods. Retrospective analysis of eyes with idiopathic perifoveal telangiectasia (IPT), diabetic macular edema (DME), idiopathic central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), or cone dystrophy (CD) and eyes of healthy control subjects. OCT scans were performed. Raw scan data were exported and used to calculate light reflectivity profiles. Reflectivity data were acquired by projecting three rectangular boxes, each 50 pixels long and 5 pixels wide, into the intraretinal ...
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    7. A New Method to Monitor Visual Field Defects Caused by Photoreceptor Degeneration by Quantitative Optical Coherence Tomography

      purpose. To correlate the dimension of the visual field (VF) tested by Goldman kinetic perimetry with the extent of visibility of the highly reflective layer between inner and outer segments of photoreceptors (IOS) seen in optical coherence tomography (OCT) images in patients with retinitis pigmentosa (RP). methods. In a retrospectively designed cross-sectional study, 18 eyes of 18 patients with RP were examined with OCT and Goldmann perimetry using test target I4e and compared with 18 eyes of 18 control subjects. A-scans of raw scan data of Stratus OCT images (Carl Zeiss Meditec, AG, Oberkochen, Germany) were quantitatively analyzed for the ...
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    8. In Situ Ultrahigh-resolution Optical Coherence Tomography Characterization of Eye Bank Corneal Tissue Processed for Lamellar Keratoplasty.

      Purpose: To use optical coherence tomography (OCT) as a noninvasive tool to perform in situ characterization of eye bank corneal tissue processed for lamellar keratoplasty. Methods: A custom-built ultrahigh-resolution OCT (UHR-OCT) was used to characterize donor corneal tissue that had been processed for lamellar keratoplasty. Twenty-seven donor corneas were analyzed. Four donor corneas were used as controls, whereas the rest were processed into donor corneal buttons for lamellar transplantation by using hand dissection, a microkeratome, or a femtosecond laser. UHR-OCT was also used to noninvasively characterize and monitor the viable corneal tissue immersed in storage medium over 3 weeks. Results ...

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    9. Correlation of Visual Function Impairment and Optical Coherence Tomography Findings in Patients with Adult-Onset Foveomacular Vitelliform Macular Dystrophy

      PurposeTo investigate the relationship between morphologic and functional abnormalities in patients affected with adult-onset foveomacular vitelliform macular dystrophy (AFVD).DesignProspective, noncomparative observational study.MethodsA complete ophthalmologic examination, including best-corrected visual acuity (BCVA), fundus examination, fundus-related perimetry, and optical coherence tomography (OCT), was performed in 20 consecutive AFVD patients. The stage of the disease and the thickness of the neuroepithelium at the foveola (neurosensory retina) were compared with the BCVA as well as with the type of scotoma, the average retinal sensitivity, and the location and stability of fixation.ResultsThirty-five eyes of 20 consecutive patients (10 men and 10 women; mean ...

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    10. Ultrastructural Correlation of Spectral-Domain Optical Coherence Tomographic Findings in Vitreomacular Traction Syndrome

      Purpose To examine the ultrastructural correlates of spectral-domain optical coherence tomography (SD-OCT) findings in patients with vitreomacular traction (VMT). Design Observational case series. Methods Retrospective analysis of six eyes of consecutive patients who underwent vitrectomy surgery for VMT was performed in this single-center, noncomparative study. One patient had a concurrent macular hole. Preoperative assessment included SD-OCT examination with 3-dimensional image reconstruction. During surgery the vitreous cone was dissected from the vitreous body using scissors, then removed from the surface of the retina with a combination of sharp dissection and peeling, and subsequently submitted for histologic and transmission electron microscopic processing ...
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    11. The prevalence of cystoid macular oedema in retinitis pigmentosa patients determined by optical coherence tomography

      Aims: To determine the prevalence of cystoid macular oedema (CMO) in retinitis pigmentosa (RP) patients of various genetic subtypes using optical coherence tomography (OCT). Methods: We performed a complete ocular examination on 124 RP patients including best corrected visual acuity, intraocular pressure measurement, anterior segment and a detailed fundus exam. OCT images were then acquired using two different units. The presence of hypo-reflective lacunae was used to diagnose CMO. Results: Of the 124 patients, 47 showed CMO in at least one eye (38%), while 34 showed CMO in both eyes (27%). The prevalence of CMO in at least one eye ...
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    12. Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients

      Aim: To compare the retinal nerve fibre layer (RNFL) thickness in eyes of migraine patients with age-matched healthy subjects using optical coherence tomography. Methods: The study was designed as an observational cross-sectional study. 70 eyes of 70 patients (mean age 28.2 (SD 7.9) years) with migraine with or without aura according to the criteria of the Headache International Society and 53 eyes of 53 age-matched healthy controls (mean age 28.0 (8.1) years) were included. Optical coherence tomography was performed with the Stratus OCT (model 3000, software ver. 4.0.2; Carl Zeiss Meditec, Dublin, CA) after ...
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    13. Peripapillary retinal nerve fibre layer thickness in highly myopic Caucasians as measured by Stratus optical coherence tomography

      Aims: To assess peripapillary retinal nerve fibre layer (RNFL) thickness distribution in a group of non-glaucomatous Caucasian subjects with a high degree of myopia and to evaluate the relationship between RNFL thickness, both global and sectoral, and other variables including axial length and optic disc size. Method: 31 eyes of 31 healthy Caucasian subjects with spherical equivalent >=–6 dioptres (D) were recruited from a community optometric practice. RNFL thickness was measured using the Stratus optical coherence tomography (OCT) Fast RNFL 3.4 mm scan protocol. Optic disc area was measured using the Heidelberg Retinal Tomograph II and axial length using ...
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    14. Comparison of the optical coherence tomographic features of choroidal neovascular membranes in pathological myopia versus age-related macular degeneration, using quantitative subanalysis

      Aim: To compare the retinal morphological characteristics of eyes with choroidal neovascularisation (CNV) secondary to pathological myopia versus eyes with CNV secondary to age-related macular degeneration (AMD), using quantitative optical coherence tomography (OCT) subanalysis. Methods: Twenty-one eyes of 21 patients newly diagnosed as having CNV secondary to pathological myopia, and 43 consecutive cases of eyes with newly diagnosed subfoveal CNV secondary to AMD were retrospectively collected. In all patients, StratusOCT images and fluorescein angiograms (FA) were available for analysis. StratusOCT images were analysed using custom software (termed "OCTOR"), which allowed calculation of the thickness/volume of the neurosensory retina, subretinal ...

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    15. Corneal wound malapposition after penetrating keratoplasty: an optical coherence tomography study

      Aims: To examine the wound configuration after penetrating keratoplasty (PKP) using anterior segment optical coherence tomography (OCT). Methods: All PKP patients who were examined for routine follow-up, between November and December 2006, after having all their sutures removed were included. Patients underwent clinical examination, refraction, corneal topography, aberrometry and Visante anterior segment OCT. Results: 204 graft–host sections from 27 eyes (25 patients, mean age 51.6 (SD 17.7) years) were analysed. Although all the graft–host junctions had continuous smooth epithelial surfaces, 124 of them (60.8%) had internal graft–host malappositions such as gapes (15.7%), steps ...
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    16. Retinopathy of Coton de Tulear dogs: clinical manifestations, electroretinographic, ultrasonographic, fluorescein and indocyanine green angiographic, and optical coherence tomographic findings

      ABSTRACT Objectives To document the clinical manifestations, development, progression, and mode of inheritance of the retinopathy of Coton de Tulear dogs. Materials and methods Multiple Coton de Tulear dogs were examined with biomicroscopy, indirect ophthalmoscopy, photopic and scotopic electroretinography, fluorescein and indocyanine green angiography, optical coherence tomography, ultrasonography, and fundic photography for 3 years. Results The retinopathy of Coton de Tulear dogs is inherited as an autosomal recessive condition and manifests as multifocal serous retinal detachments in homozygous puppies, between 3 and 4 months of age. Optic coherence tomography and ultrasonography confirm multiple focal serous retinal detachments. Serial fundic photographs ...
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    17. Retinopathy of Coton de Tulear dogs: clinical manifestations, electroretinographic, ultrasonographic, fluorescein and indocyanine green angiographic, and optical coherence tomographic findings.

      Related Articles Retinopathy of Coton de Tulear dogs: clinical manifestations, electroretinographic, ultrasonographic, fluorescein and indocyanine green angiographic, and optical coherence tomographic findings. Vet Ophthalmol. 2008 Jul-Aug;11(4):242-9 Authors: Grahn BH, Sandmeyer LL, Breaux C Objectives To document the clinical manifestations, development, progression, and mode of inheritance of the retinopathy of Coton de Tulear dogs. Materials and methods Multiple Coton de Tulear dogs were examined with biomicroscopy, indirect ophthalmoscopy, photopic and scotopic electroretinography, fluorescein and indocyanine green angiography, optical coherence tomography, ultrasonography, and fundic photography for 3 years. Results The retinopathy of Coton de Tulear dogs is inherited as ...
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    18. Intra-observer and Inter-observer Reliability and Reproducibility of Slit-Lamp–Adapted Optical Coherence Tomography for Evaluation of Anterior Chamber Depth and Central Corneal Thickness

      BACKGROUND AND OBJECTIVE To evaluate the intra-observer and inter-observer reproducibility of anterior chamber depth (ACD) and central corneal thickness (CCT) measurements taken by slit-lamp–adapted optical coherence tomography (SL-OCT) and to evaluate concordance of CCT and ACD values obtained by SL-OCT with gold standard devices. PATIENTS AND METHODS Three images of each eye were taken by two different operators using SL-OCT. ACD and CCT values obtained by each operator were determined and compared to one another and to ultrasonic pachymetry (CCT) and axial OCT biometry (ACD) values obtained by a third, masked operator. Intra-observer and inter-operator reproducibility was assessed using ...
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    19. Detailed Visualization of the Anterior Segment Using Fourier-Domain Optical Coherence Tomography

      Objective To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. Methods A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study. Results Schlemm’s canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures ...
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    20. Image Processing and Clinical Applications of Anterior Segment Optical Coherence Tomography (Thesis)

      Image Processing and Clinical Applications of Anterior Segment Optical Coherence Tomography (Thesis)
      Optical coherence tomography (OCT) is an emerging imaging modality. It provides in vivo cross-sectional images with micron level resolution. OCT is attractive for imaging the anterior eye segment because of its characteristics on high resolution, non-contact, and easy anatomical interpretation. The fast data acquisition rate (>2000 axial scans per second) of current anterior segment OCT systems allows the measurement of corneal dimensions without significant motion error. It also generates huge amount of data. Manual anatomic reconstruction and measurement are time consuming and operator-dependent. Automated image processing and analysis techniques can overcome these limitations and make routine clinical use of OCT ...
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    21. A Pilot Study of Fourier-Domain Optical Coherence Tomography of Retinal Dystrophy Patients

      Purpose To characterize the macular anatomy of retinal dystrophy eyes using high-speed, high-resolution, Fourier-domain optical coherence tomography (FD-OCT). Design Case-control study. Methods Retinal dystrophy patients and normal age- and gender-matched controls underwent FD-OCT imaging using the RTVue (Optovue Inc, Fremont, California, USA). Vertical and horizontal 8-mm scans of 1024 lines/cross-section were obtained. Based on boundaries manually drawn on computer displays of OCT cross-sections, the thicknesses of the retina, inner retinal layer (IRL), and outer retinal layer (ORL) were averaged over both 5-mm (macular) and 1.5-mm (foveal) regions centered at the fovea. The IRL was the sum of nerve ...
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    22. OCT-based re-injections for anti-VEGF-treatment for neovascular Armd.

      [OCT-based re-injections for anti-VEGF-treatment for neovascular ARMD.] Ophthalmologe. 2008 Jul 19; Authors: Schaal KB, Höh AE, Scheuerle A, Schütt F, Dithmar S BACKGROUND: We present an optical coherence tomography (OCT)-based individual reinjection procedure for bevacizumab treatment in neovascular age-related macular degeneration (ARMD). METHODS: Thirty-two patients with active subfoveal occult choroidal neovascularisation in ARMD received a single intravitreal injection of 1.25 mg bevacizumab and were reinjected based on new or persisting subretinal or intraretinal fluid on OCT. Patient visits were every 6-8 weeks. RESULTS: After a single injection, 74% of patients demonstrated complete retinal fluid absorption, with ...
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