1. Articles in category: Ophthalmology

    73-96 of 13767 « 1 2 3 4 5 6 7 ... 572 573 574 »
    1. Stack generalized deep ensemble learning for retinal layer segmentation in Optical Coherence Tomography images

      Stack generalized deep ensemble learning for retinal layer segmentation in Optical Coherence Tomography images

      0Segmentation of retinal layers is a vital and important step in computerized processing and the study of retinal Optical Coherence Tomography (OCT) images. However, automatic segmentation of retinal layers is challenging due to the presence of noise, widely varying reflectivity of image components, variations in morphology and alignment of layers in the presence of retinal diseases. In this paper, we propose a Fully Convolutional Network (FCN) termed as DelNet based on a deep ensemble learning approach to selectively segment retinal layers from OCT scans. The proposed model is tested on a publicly available DUKE DME dataset. Comparative analysis with other ...

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    2. The Pigtail Sign: A New Spectral Domain Optical Coherence Tomography Finding After Inverted ILM Flap Surgery for Idiopathic Macular Hole

      The Pigtail Sign: A New Spectral Domain Optical Coherence Tomography Finding After Inverted ILM Flap Surgery for Idiopathic Macular Hole

      Purpose: To report a new spectral domain optical coherence tomography (OCT) finding called the pigtail sign. It was found during follow-up of idiopathic macular hole cases after inverted internal limiting membrane (ILM) flap surgery. Methods: This is a retrospective case series of 12 eyes (12 patients) who underwent inverted ILM flap technique for idiopathic macular hole closure. Spectral domain optical coherence tomography images were analyzed for the presence of this new finding. Results: A new spectral domain OCT finding of a curved coiled line hanging above the surface of the retinal layers was seen in all patients. The mean preoperative ...

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    3. Guidelines for imaging the choriocapillaris using OCT angiography

      Guidelines for imaging the choriocapillaris using OCT angiography

      Purpose To provide guidance on how to appropriately quantitate various choriocapillaris (CC) parameters with optical coherence tomography angiography (OCTA). Design Evidence-based perspective. Methods Review of literature and experience of authors. Results Accurate and reliable quantification of the CC using OCTA requires that the CC can be visualized and that the measurements of various CC parameters are validated. For accurate visualization, the selected CC slab must be physiologically sound, must produce images consistent with histology, and must yield qualitatively similar images when viewing repeats of the same scan or scans of different sizes. For accurate quantification, the measured inter-capillary distances (ICDs ...

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    4. An Intelligent Optical Coherence Tomography-based System for Pathological Retinal Cases Identification and Urgent Referrals

      An Intelligent Optical Coherence Tomography-based System for Pathological Retinal Cases Identification and Urgent Referrals

      Purpose : This study aimed to develop an automated system with artificial intelligence algorithms to comprehensively identify pathologic retinal cases and make urgent referrals. Methods : To build and test the intelligent system, this study obtained 28,664 optical coherence tomography (OCT) images from 2254 patients in the Eye and ENT Hospital of Fudan University (EENT Hospital) and Shanghai Tenth People's Hospital (TENTH Hospital). We applied a deep learning model with an adapted feature pyramid network to detect 15 categories of retinal pathologies from OCT images as common signs of various retinal diseases. Subsequently, the pathologies detected in the OCT images ...

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    5. Sensitivity and specificity of choroidal thickness measurement by EDI-OCT for central serous chorioretinopathy diagnosis

      Sensitivity and specificity of choroidal thickness measurement by EDI-OCT for central serous chorioretinopathy diagnosis

      Purpose To evaluate the utility of choroidal thickness (CT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT) for central serous chorioretinopathy (CSC) diagnosis. Methods Cross-sectional comparative study of 62 consecutive patients: 38 with acute CSC and 24 with macular subretinal fluid from differential diagnoses (DD). Subfoveolar choroidal thickness was measured using EDI 9-mm horizontal protocol. We evaluated sensitivity, specificity and intraclass correlation coefficient. Results Mean subfoveolar CT was greater in CSC group than in DD group (465.45 ± 115.42 μm vs. 347.54 ± 111.27 μm, p  < 0.001). The best threshold measure was 390 μm in patients ...

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    6. Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

      Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

      Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a unique biomarker for objective optoretinography (ORG) of photoreceptor function. We report here the first-time in vivo ORG detection of photoreceptor dysfunction due to retinal degeneration. A custom-designed optical coherence tomography (OCT) was employed for longitudinal ORG monitoring of photoreceptor-IOS distortions in retinal degeneration mice. Depth-resolved OCT analysis confirmed the outer segment (OS) as the physical source of the photoreceptor-IOS. Comparative ERG measurement verified the phototransduction activation as the physiological correlator of the photoreceptor-IOS. Histological examination ...

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    7. Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images

      Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images

      Purpose: To evaluate the performance of a deep learning-based, fully automated, multi-class, macular fluid segmentation algorithm relative to expert annotations in a heterogeneous population of confirmed wet age-related macular degeneration (wAMD) subjects. Methods: Twenty-two swept-source optical coherence tomography (SS-OCT) volumes of the macula from 22 from different individuals with wAMD were manually annotated by two expert graders. These results were compared using cross-validation (CV) to automated segmentations using a deep learning-based algorithm encoding spatial information about retinal tissue as an additional input to the network. The algorithm detects and delineates fluid regions in the OCT data, differentiating between intra- and ...

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    8. Recent advances in imaging technologies for assessment of retinal diseases

      Recent advances in imaging technologies for assessment of retinal diseases

      Introduction Retinal imaging is a key investigation in ophthalmology. New devices continue to be created to keep up with the demand for better imaging modalities in this field. This review looks to highlight current trends and the future of retinal imaging. Areas covered This review looks at the advances in topographical imaging, photoacoustic microscopy, optical coherence tomography and molecular imaging. There is future scoping Expert opinion Retinal imaging continues to develop at a rapid pace to improve diagnosis and management of patients. We will see the development of big data to gain powerful insights and new technologies such as teleophthalmology ...

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    9. Optical Coherence Tomography Can Be Used to Assess Glaucomatous Optic Nerve Damage in Most Eyes With High Myopia

      Optical Coherence Tomography Can Be Used to Assess Glaucomatous Optic Nerve Damage in Most Eyes With High Myopia

      Precis: It is generally assumed that optical coherence tomography ( OCT ) cannot be used to diagnose glaucomatous optic neuropathy ( GON ) in high myopes. However, this study presents evidence that there is sufficient information in OCT scans to allow for accurate diagnosis of GON in most eyes with high myopia . Purpose: The purpose of this study was to test the hypothesis that glaucomatous damage can be accurately diagnosed in most high myopes via an assessment of the OCT results. Patients and Methods: One hundred eyes from 60 glaucoma patients or suspects, referred for OCT scans and evaluation, had corrected spherical refractive errors ...

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    10. Evaluation of The Foveal Avascular Zone Alterations Through Optical Coherence Tomography Angiography In Eyes With Retinal Vein Occlusion

      Evaluation of The Foveal Avascular Zone Alterations Through Optical Coherence Tomography Angiography In Eyes With Retinal Vein Occlusion

      Background: To detect the effectiveness of OCT-A in evaluation of foveal avascular zone (FAZ) alterations in eyes with retinal vein occlusion . Objectives: To investigate the relationship between best-corrected visual acuity (BCVA) and the FAZ in patients with (RVO) evaluated with (OCT-A) in comparison to the unaffected fellow eyes. Patients and Methods: We retrospectively reviewed the medical records of 15 patients with (RVO); BRVO in 8 patients, CRVO in 7 patients) and we considered the unaffected fellow eyes of these patients as a control group, who were evaluated by OCT-A by a 6 mm × 6-mm region scan centered on the fovea ...

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    11. Comparison of ocular surface squamous neoplasia and pterygium using anterior segment optical coherence tomography angiography

      Comparison of ocular surface squamous neoplasia and pterygium using anterior segment optical coherence tomography angiography

      Purpose To compare ocular surface squamous neoplasia (OSSN) and pterygium using anterior segment optical coherence tomography angiography (AS-OCTA). Observations Flow patterns of conjunctival vessels in patients with OSSN and pterygium were investigated using AS-OCTA. In case 1, slit-lamp examination of a 72-year-old woman revealed an elevated lesion with increased permeability of fluorescein in the inferior nasal conjunctiva of her left eye. AS-OCTA showed markedly meandering large blood vessels in both the superficial and deep layers. Histopathological evaluation of the conjunctival biopsy indicated conjunctival intraepithelial neoplasia. Case 2 was that of a 79-year-old man with a history of three conjunctival tumor ...

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      Mentions: Osaka University
    12. Stepwise segmentation error correction in optical coherence tomography angiography images of patients with diabetic macular edema

      Stepwise segmentation error correction in optical coherence tomography angiography images of patients with diabetic macular edema

      Aim: To determine the minimum number of optical coherence tomography B-scan corrections required to provide acceptable vessel density measurements on optical coherence tomography angiography images in eyes with diabetic macular edema. Methods: In this prospective, noninterventional case series, the optical coherence tomography angiography images of eyes with center-involving diabetic macular edema were assessed. Optical coherence tomography angiography imaging was performed using RTVue Avanti spectral-domain optical coherence tomography system with the AngioVue software (V.2017.1.0.151; Optovue, Fremont, CA, USA). Segmentation error was recorded and manually corrected in the inner retinal layers in the central foveal, 100th and 200th ...

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      Mentions: Optovue
    13. Johns Hopkins Receives NIH Grant for Enabling Technology for Image-Guided Robot-Assisted Sub-Retinal Injections.

      Johns Hopkins Receives NIH Grant for Enabling Technology for Image-Guided Robot-Assisted Sub-Retinal Injections.

      Johns Hopkins Receives a 2020 NIH Grant for $504,023 for Enabling Technology for Image-Guided Robot-Assisted Sub-Retinal Injections. The principal investigator is Iulian Iordachita. Below is a summary of the proposed work. The goal of this proposal is to design, develop and evaluate a novel clinically compatible surgical platform for enhancing the retina surgeon's ability to provide therapy to the subretinal domain. Efficient, safe, reproducible delivery methods would enable safe and precise delivery of stem cell, nanoparticle and gene therapies for prevalent ocular diseases including but not limited to Age-related Macular Degeneration (AMD). The proposed cooperative surgical robot utilizes ...

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    14. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2020 NIH Grant for $299,643 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease. The principal investigator is Danny Wang. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are inaccessible to existing imaging technologies. Characteristic parenchymal lesions on MRI ...

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    15. Comparison of foveal optical coherence tomography angiography findings between premature children with ROP and non-premature healthy children

      Comparison of foveal optical coherence tomography angiography findings between premature children with ROP and non-premature healthy children

      Our aim is to compare foveal microvascular structure, foveal retinal thickness, and best-corrected visual acuity (BCVA) in children with a history of premature retinopathy (ROP) and healthy children. It is also evaluated whether microvascular structural changes in the course of ROP had resulted from treatment modalities of ROP or the disease itself. Methods This is a cross-sectional observational comparative study. Seventy-one children were analyzed in four different groups: children treated with bevacizumab (18), or laser (19) for ROP; or spontaneously regressed disease (18) and non-premature healthy children (16). We analyzed foveal avascular zone (FAZ) and vessel densities (VDs) of the ...

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    16. Analysis of optical coherence angiography in cystoid macular oedema associated with gyrate atrophy

      Analysis of optical coherence angiography in cystoid macular oedema associated with gyrate atrophy

      Background To evaluate the relationship between superficial, deep foveal avascular zone (FAZ) and foveal cyst areas in eyes with cystoid macular oedema (CMO) associated with gyrate atrophy of the choroid and retina (GA). Methods This is a retrospective collaborative multicenter study of optical coherence tomography-angiography (OCTA) images in GA. Superficial and deep FAZ and foveal cyst were measured using Image J by two independent experts. Values were corrected for myopia magnification. These values were compared with age-matched controls from normative data. Results Twenty-three eyes from 12 patients with GA and CMO were included in the study. The mean ± standard deviation ...

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    17. Role of wide-angle optical coherence tomography angiography in detection of proliferative diabetic retinopathy in a patient with dense asteroid hyalosis

      Role of wide-angle optical coherence tomography angiography in detection of proliferative diabetic retinopathy in a patient with dense asteroid hyalosis

      A 56-year-old woman presented with painless diminution of vision in her left eye since the last 2 months. She is a known case of type 2 diabetes mellitus on insulin. Her best-corrected visual acuity in right eye was 20/60; N8 and left eye were only counting fingers close to face. She was a known case of primary angle-closure glaucoma and had previously undergone peripheral iridotomy in both eyes elsewhere. She had early cataractous lens changes in both eyes. Her left eye, in addition, also showed faint iris neovascularisation at 2’o clock. Her intraocular pressure in the right and ...

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    18. Spectral-domain optical coherence tomography features in cases of pre-eclampsia and the relationship with systemic parameters

      Spectral-domain optical coherence tomography features in cases of pre-eclampsia and the relationship with systemic parameters

      Pre-eclampsia is a multisystem progressive disorder characterized by the new onset of hypertension and proteinuria or end-organ dysfunction in the last half of pregnancy. The prevalence of retinal involvement may vary according to the severity of pre-eclampsia. The correlation between systemic features and retinal morbidity in pre-eclamptic women is still controversial. To the best of our knowledge, there is lack of data regarding the correlation between other systemic features and retinal morbidity.

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    19. Retinal microvasculature impairment in patients with congenital heart disease investigated by optical coherence tomography angiography

      Retinal microvasculature impairment in patients with congenital heart disease investigated by optical coherence tomography angiography

      Importance A high prevalence of retinal abnormalities have been reported in congenital heart disease (CHD), but quantitative analysis of retinal vasculature is scarce. Optical coherence tomography angiography (OCTA) is a noninvasive method to quantitatively assess the retinal microvasculature. Background To investigate the retinal microvasculature changes in CHD patients by using OCTA. Design Cross‐sectional study. Participants A total of 158 participants including 57 cyanotic CHD (CCHD) patients, 60 acyanotic CHD (ACHD) patients, and 41 control subjects were included. Methods All participants underwent a comprehensive ophthalmologic examination, including refraction measurement, intraocular pressure measurement, and OCTA. Main Outcome Measures Vessel density (VD ...

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    20. Association between sleep apnoea risk score and retinal microvasculature using optical coherence tomography angiography

      Association between sleep apnoea risk score and retinal microvasculature using optical coherence tomography angiography

      Purpose To investigate the retinal vessel changes at peripapillary and parafoveal regions using optical coherence tomography angiography in patients with varying obstructive sleep apnoea syndrome (OSAS) risk, identified by the STOP-BANG questionnaire. Design Prospective, hospital-based cross-sectional study. Methods Participants were divided into 3 groups based on the OSAS risk score. Flow areas and vessel densities were calculated at peripapillary and parafoveal regions using optical coherence tomography angiography. Microvasculature changes between the 3 groups and correlation between OSAS risk score and vascular changes were calculated. Results Six hundred and six eyes of 303 patients were included in groups 1 (n=96 ...

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      Mentions: Rohit Shetty
    21. Measurement of macular thickness with optical coherence tomography: impact of using a paediatric reference database and analysis of interocular symmetry

      Measurement of macular thickness with optical coherence tomography: impact of using a paediatric reference database and analysis of interocular symmetry

      Purpose Optical coherence tomography (OCT) software is used to classify abnormality of macular thickness by colour category based on reference data from adult series. We assessed the impact of using paediatric reference thickness values for macular thickness instead of adult reference values. Methods Cross-sectional study. Primary and tertiary healthcare setting. Out of 140 healthy participants aged 5 to 18 years, 126 were eligible, 83% from European origin. Following a dilated eye examination and cycloplegic refraction, participants underwent macular scanning with OCT (Topcon 3D OCT-2000). Macular thickness paediatric reference values were recorded by spherical equivalent (SE) and sex, and the specific ...

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    22. Refractive surprise after cataract surgery secondary to smeared optics of swept-source optical coherence tomography biometer: a case report

      Refractive surprise after cataract surgery secondary to smeared optics of swept-source optical coherence tomography biometer: a case report

      Background Inaccurate biometry can lead to the wrong intraocular lens implantation and result in refractive surprise following cataract surgery. It is important to be sceptical of biometry results that do not match the refractive or clinical picture and ask for it to be repeated. Case presentation We present a unique cause of refractive surprise in a patient undergoing cataract surgery. Pre-operative refraction demonstrated hypermetropia, yet swept-source optical coherence tomography (SS-OCT) biometry repeatedly calculated the axial length as > 35.00 mm in both eyes. The patient underwent phacoemulsification and intraocular lens insertion using the provided biometry calculations, however post-operatively the patient ...

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    23. Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

      Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

      Objectives: To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL). Materials and Methods: A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study. Refraction and biometry measurements were performed. Retinal nerve fiber layer thickness (RNFLT), central macular volume, and central macular thickness (CMT) were measured by optical coherence tomography (OCT) after dilatation. Using the ...

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    24. Is optical coherence tomography angiography a useful tool in the screening of hydroxychloroquine retinopathy?

      Is optical coherence tomography angiography a useful tool in the screening of hydroxychloroquine retinopathy?

      Purpose To detect the early changes in retinal vasculature via optical coherence tomography angiography (OCTA) by comparing the quantitative OCTA parameters in the group of patients who were using hydroxychloroquine (HCQ) or not. Methods This was a cross-sectional, comparative, and observational study. The patients who were newly or previously prescribed HCQ for an autoimmune disease were included. OCTA imaging was performed via OCT RT XR Avanti with AngioVue software (Optivue Inc, Freemont, CA). The study group had two groups: a control group (patients newly diagnosed and who were not taking any medication) and a treatment group (patients who were receiving ...

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