1. Articles in category: Ophthalmology

    73-96 of 11162 « 1 2 3 4 5 6 7 ... 463 464 465 »
    1. Evaluation of anterior chamber volume using Pentacam and anterior segment optical coherence tomography among normal subjects

      Evaluation of anterior chamber volume using Pentacam and anterior segment optical coherence tomography among normal subjects

      Aim: To compare the anterior chamber volume measurements obtained with Pentacam and derived from anterior segment optical coherence tomography. Design: Cross-sectional study. Methods: We included normal subjects who underwent a comprehensive eye examination including refraction, keratometry, Goldmann applanation tonometry, gonioscopy, anterior segment optical coherence tomography (AS-OCT) (Carl Zeiss Meditec Inc.; Dublin, CA, USA) and Pentacam (Oculus Inc.; Lynnwood, WA, USA). Fifty scans were selected for Pentacam and 12 images were selected for calculation of anterior chamber volume. Only the right eye was considered for analysis. Results: One-hundred and nineteen eyes of 119 subjects were included for analysis. The mean age ...

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    2. Optical Coherence Tomography in Disorders of the Central Nervous System

      Optical Coherence Tomography in Disorders of the Central Nervous System

      Retinal changes and visual symptoms are present in several inflammatory, degenerative and tumorous disorders of the central nervous system (CNS). Optical coherence tomography (OCT) is a method that can be used in clinical practice to detect and quantify the structural correlates of these visual symptoms in neurological disorders. OCT is a non-invasive imaging technique, based on interferometry, which can create high-resolution images of the retina and measure the thickness and volume of the different retinal layers. The combined ganglion cell- and inner plexiform layer (GCIPL) and the peripapillary retinal nerve fibre layer (pRNFL) are of particular interest in the field ...

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    3. Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Fundus autofluorescence (FAF) imaging is commonly used in ophthalmic clinics for diagnosis and monitoring of retinal diseases. Lipofuscin in the retinal pigment epithelium (RPE), with A2E as its most abundant component and a visual cycle by-product, is the major fluorophore of FAF. Lipofuscin accumulates with age and is implicated in degenerative retinal diseases. The amount of lipofuscin in RPE can be assessed by quantitative measurement of FAF. However, the currently available FAF imaging technologies are not capable of quantifying the absolute intensity of FAF, which is essential for comparing images from different individuals, and from the same individual over time ...

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    4. Optical coherence tomography apparatus for selectively visualizing and analyzing vascular network of choroidal layer, and image-processing program and image-processing method for the same

      Optical coherence tomography apparatus for selectively visualizing and analyzing vascular network of choroidal layer, and image-processing program and image-processing method for the same

      From OCT-measured data, only the image data of the choroidal vascular network present in the layer of the choroidal layer is selectively extracted, thereby accurately obtaining the thickness of the choroidal vessels and thickness of the choroidal vascular network from the image data, to allow for quantitative evaluation of the choroidal vascular network. The optical coherence tomography apparatus has an optical coherence tomography device, and a computer that processes the three-dimensional OCT tomographic images obtained based on the OCT-measured data acquired by the optical coherence tomography device. The computer functions as a means for selectively separating out only the images ...

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    5. Correlation of “Panoramic” Optical Coherence Tomography Angiography With Indocyanine Green Angiography Characteristics of Serpiginous-Like Choroiditis

      Correlation of “Panoramic” Optical Coherence Tomography Angiography With Indocyanine Green Angiography Characteristics of Serpiginous-Like Choroiditis

      BACKGROUND AND OBJECTIVES: To analyze the panorama optical coherence tomography angiography (P-OCTA) characteristics of serpiginous-like choroiditis (SLC) and to correlate these findings with indocyanine green angiography (ICGA). PATIENTS AND METHODS: Prospective, observational study of 32 eyes of 24 patients. Twenty-seven eyes of 16 patients who met inclusion criteria were included in the final study. Multimodal imaging was performed using P-OCTA, OCT, fundus autofluorescence, fluorescein angiography, and ICGA. Morphologic features at the site of lesions were analyzed using P-OCTA and correlated with ICGA. RESULTS: P-OCTA in active phase revealed areas of large flow void, which correlated with hypofluorescent areas on ICGA ...

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    6. Anatomic Localization of Type 1 and Type 2 Macular Neovascularization Using Swept-Source OCT Angiography

      Anatomic Localization of Type 1 and Type 2 Macular Neovascularization Using Swept-Source OCT Angiography

      BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography angiography (SS-OCTA) and different boundary-specific segmentation strategies were used to distinguish type 1 macular neovascularization (MNV) from type 2 MNV in eyes with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Eyes with exudative AMD were enrolled in a prospective study. Segmentation strategies included a slab from the outer retina (OR) to the choriocapillaris (CC) for the entire MNV, a slab from the retinal pigment epithelium (RPE) to the CC for the type 1 MNV, and a slab from the OR to the RPE for the type 2 MNV. RESULTS: In 13 eyes ...

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    7. Choroidal Neovascularization in Torpedo Maculopathy Assessed on Optical Coherence Tomography Angiography

      Choroidal Neovascularization in Torpedo Maculopathy Assessed on Optical Coherence Tomography Angiography

      Torpedo maculopathy is characterized by a congenital, unilateral, and torpedo-shaped chorioretinal lesion with unclear pathogenesis and evolution. Although the optical coherence tomography angiography (OCTA) characteristics have already been defined in literature, the authors describe for the first time the presence of choroidal neovascularization (CNV) on the temporal edge of this lesion in a 36-year-old woman with a history of altered visual field in her left eye. The authors' investigation supports the hypothesis of an aberrant choroidal circulation underlying the pathogenesis of this condition, and proves the advantage conferred by OCTA in CNV detection over the other angiographic techniques.

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    8. Choroidal imaging biomarkers

      Choroidal imaging biomarkers

      The choroid is the vascular coat of the eye,and its role has been studied in multiple chorioretinal disorders. The recent advancements in choroidal imaging techniques including enhanced depth imaging optical coherence tomography (EDI-OCT), swept source (SS-OCT), enface OCT and OCT angiography have facilitated an in-depth analysis of choroid. The gradual shift from manual to automated segmentation and binarization methods have led to precise and reproducible measurements of choroidal parameters. These qualitative and quantitative parameters, called choroidal imaging biomarkers, have evolved over the past decade from a simple linear subfoveal choroidal thickness to more complex 3 dimensional (3-D) choroidal reconstruction ...

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    9. Correlation between morphological characteristics in spectral‐domain‐optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy

      Correlation between morphological characteristics in spectral‐domain‐optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy

      Purpose The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice. Methods Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center. These morphologic characteristics were compared with functional variables [best‐corrected visual acuity (BCVA), contrast sensitivity (CS), retinal sensitivity/microperimetry, fixation stability], and patients’ subjective handicap from CSC using the ...

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    10. A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

      A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

      AIM : To compare the clinical performance of 4 spectral-domain (SD) optical coherence tomography angiography (OCTA) systems: AngioVueTM, AngioPlexTM, Spectralis® OCTA, AngioScan, and 1 swept-source (SS) OCTA SS OCT AngioTM. METHODS : Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm2 scan pattern (Spectralis OCTA for 3×3 mm2 scan only). Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance (ANOVA) with Bonferroni's post-test and Friedman test with Dunn's post-test were used to ...

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    11. Investigating the reliability and clinical utility of minimally invasive portable electroretinography and optical coherence tomography techniques in children undergoing vigabatrin therapy (Thesis)

      Investigating the reliability and clinical utility of minimally invasive portable electroretinography and optical coherence tomography techniques in children undergoing vigabatrin therapy (Thesis)

      The antiepileptic drug for Infantile Spasms – vigabatrin, has been associated with retinal toxicity in over one third of children treated. Young and non-verbal children cannot cooperate with conventional adult-oriented monitoring devices, therefore a safe and reliable technique to monitor for vigabatrin retinal toxicity is missing. This study evaluated the tolerability, reliability and clinical feasibility of two alternative, handheld systems for assessment of retinal function: the RETeval ERG and Envisu OCT. We found that non-sedated children showed poor tolerability on the RETeval ERG. Under sedation the same children showed high tolerability on the handheld OCT. Responses from both techniques demonstrated good ...

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    12. Optical coherence tomography in the diagnosis of sarcoidosis of lung and other organs

      Optical coherence tomography in the diagnosis of sarcoidosis of lung and other organs

      Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomas. The disease can affect the lungs, skin, lymph nodes, eyes, liver, heart, and brain. As for the eyes it occupies 3-4 place among organs-target. Diagnosis of eye sarcoidosis is quite complicated and is usually found in ophthalmologic examination. Objective: Studying of diagnostic significance of additional methods of ophthalmology examination for sarcoidosis of lung and other localizations. Methods: It was a prospective investigation. The study group consisted of patients with the first identified sarcoidosis in different organs. The control group consisted of patients with tuberculosis ...

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    13. Optical coherence tomography angiography analysis of changes in the retina and the choroid after haemodialysis

      Optical coherence tomography angiography analysis of changes in the retina and the choroid after haemodialysis

      The purpose of this study is to evaluate the effect of haemodialysis on perfused vessel density, choroidal thickness (CT), and retinal thickness in end-stage renal disease (ESRD) using swept-source optical coherence tomography angiography (SS-OCTA). We studied twenty-nine eyes of 29 ESRD patients by ophthalmologic examination and SS-OCTA before and after haemodialysis. The colour-coded perfusion density maps were generated and perfused vessel density was calculated. Changes in systemic and other ocular parameters such as retinal and choroidal thickness were measured and analysed. Total perfused vessel density decreased significantly after haemodialysis in the choriocapillaris; it was not significantly different in the superficial ...

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    14. Detection of Age-Related Macular Degeneration by Portable Optical Coherence Tomography Operated by Nonexpert Personnel: Potential Use for Screenings

      Detection of Age-Related Macular Degeneration by Portable Optical Coherence Tomography Operated by Nonexpert Personnel: Potential Use for Screenings

      Purpose: The purpose of this study is to determine the sensitivity and specificity of detecting age-related macular degeneration (AMD) using portable optical coherence tomography (OCT) operated by nonexpert photographers on undilated patients. Methods: In this case-control study, 92 individuals were recruited from the glaucoma and retina clinics at the Wilmer Eye Institute (Johns Hopkins University, Baltimore, MD). Using the portable iVue (Optovue, Inc, Fremont, CA) spectral-domain OCT (SD-OCT), 2 nonexpert photographers acquired retina map scans on undilated eyes of all participants. In total, 33 AMD eyes and 105 control eyes were evaluated and graded by ophthalmologists masked to the diagnoses ...

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    15. Absence of the foveal avascular zone in a nanophthalmic child revealed by optical coherence tomography angiography

      Absence of the foveal avascular zone in a nanophthalmic child revealed by optical coherence tomography angiography

      Purpose Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that does not require the use of contrast agents and that allows the visualization of the retinal microvasculature in a layer-by-layer manner without bright light. This merit allows us to obtain the fundus image in children. Retinal vessels are typically absent from the center of the fovea , an area known as the foveal avascular zone (FAZ). The purpose of the present case study was to evaluate the FAZ in a nanophthalmic pediatric patient with OCTA. Obsevations A 6-year-old girl was referred to the Hiroshima University Hospital because of ...

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    16. Changes in retinal flow density measured by optical coherence tomography angiography in patients with carotid artery stenosis after carotid endarterectomy

      Changes in retinal flow density measured by optical coherence tomography angiography in patients with carotid artery stenosis after carotid endarterectomy

      The aim of the study presented here was to evaluate retinal and optic nerve head (ONH) perfusion in patients with severe asymptomatic carotid artery stenosis (CAS) compared with healthy controls and to analyze the impact of carotid endarterectomy using optical coherence tomography angiography (OCT-A). 25 eyes of 25 patients with CAS (study group) and 25 eyes of 25 healthy controls (control group) were prospectively included in this study. OCT-A was performed using RTVue XR Avanti (Optovue, Inc, Fremont, California, USA). The flow density data in the superficial and deep retinal OCT-angiogram of the macula and in the radial peripapillary capillary ...

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    17. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF SUBRETINAL FIBROSIS AFTER MYOPIC NEOVASCULARIZATION

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF SUBRETINAL FIBROSIS AFTER MYOPIC NEOVASCULARIZATION

      Purpose: To describe the optical coherence tomography (OCT) angiography features of subretinal fibrosis in eyes with myopic choroidal neovascularization after natural evolution or secondary to intravitreal anti–vascular endothelial growth factor therapy. Methods: Retrospective observational case series. All eyes underwent a multimodal imaging examination including fluorescein angiography, spectral domain OCT, OCT angiography, and en face OCT. Results: Twenty-five eyes of 25 patients with mean age of 56.4 ± 14.9 were included in the study. Subretinal fibrosis was diagnosed at mean 30 (range 6–116) months before inclusion. Within the subretinal fibrosis , an abnormal vascular network was observed in 20 ...

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    18. SURGICAL MANAGEMENT OF TRAUMATIC MACULAR HOLE Optical Coherence Tomography Features and Outcomes

      SURGICAL MANAGEMENT OF TRAUMATIC MACULAR HOLE Optical Coherence Tomography Features and Outcomes

      Purpose: To report the outcomes of eyes receiving surgical management for traumatic macular holes. To describe the preoperative and postoperative optical coherence tomography features of traumatic macular holes and to explore associations between preoperative clinical and optical coherence tomography features, and visual outcome. Methods: Retrospective study of patients undergoing vitrectomy for traumatic macular hole and entered into the Australian and New Zealand Society of Retinal Specialists surgical registry. Preoperative clinical data, surgical details, and 3-month postoperative outcomes were recorded prospectively. Longer-term outcomes at 12 months were requested retrospectively, as were preoperative and postoperative optical coherence tomography scans. Results: Hole closure ...

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    19. Optical Coherence Tomography Angiography of Optic Disc and Macula Vessel Density in Glaucoma and Healthy Eyes

      Optical Coherence Tomography Angiography of Optic Disc and Macula Vessel Density in Glaucoma and Healthy Eyes

      Aim: To study the microvascular density of the macular and optic nerve head in healthy and glaucoma subjects using optical coherence tomography angiography . Methodology: We performed a cross-sectional cohort study on healthy subjects and patients with glaucoma . The AngioVue Enhanced Microvascular Imaging System was used to capture the optic nerve head and macula images during one visit. En face segment images of the macular and optic disc were studied in layers. Microvascular density of the optic nerve head and macula were quantified by the number of pixels measured by a novel in-house developed software. Areas under the receiver operating characteristic ...

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      Mentions: Hon-Tym Wong
    20. Macular microvasculature features before and after vitrectomy in idiopathic macular epiretinal membrane: an OCT angiography analysis

      Macular microvasculature features before and after vitrectomy in idiopathic macular epiretinal membrane: an OCT angiography analysis

      Purpose To evaluate pre-operative and post-operative morphologic characteristics in idiopathic macular epiretinal membrane (ERM) by optical coherence tomography angiography (OCTA). Methods Thirty-three subjects with unilateral idiopathic ERM were enrolled and the contralateral eyes served as controls. Vascular parameters including superficial capillary plexus (SCP), deep capillary plexus (DCP), outer capillary plexus (OCP), and choroidal capillary plexus (CCP) were evaluated by OCTA. Results The superficial foveal avascular zone (FAZ) was significantly smaller in eyes with ERM ( P  < 0.0001). The vessel densities (VDs) were significantly increased in the fovea but dramatically decreased in the parafovea in SCP and DCP of ERM eyes ...

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    21. Role of anterior segment optical coherence tomography for safer management of mature white cataracts

      Role of anterior segment optical coherence tomography for safer management of mature white cataracts

      Purpose Role of anterior segment optical coherence tomography for safer management of mature white cataracts Setting Patients with mature white cataract attending the outpatient department of a tertiary eye care hospital, aspiring to get cataract surgery done, were scheduled for elective phacoemulsification and intraocular lens implantation by two surgeons during the time period of October 2017 till March 2018. Design A prospective interventional study of 30 patients. Methods All patients with mature cataracts and absence of any retinal pathology, underwent anterior segment optical coherence tomography (ASOCT) to assess the presence or absence of intra-lenticular subcapsular fluid pockets. The patients with ...

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    22. Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography

      Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography

      Purpose To develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma. Methods This retrospective study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients. We reconstructed 3D volume data for a 3 x 3 mm disc, using a method similar to OCT angiography, and segmented the structure of the lamina cribrosa. Then, we manually segmented each laminar pore in sequential C-scan images (>90 slices at 2.6-micron intervals) with VCAT5 (RIKEN, Japan). We compared the control ...

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      Mentions: Masahiro Akiba
    23. New Interpretation of Multimodality Fundus Imaging for Retinal Cavernous Hemangioma

      New Interpretation of Multimodality Fundus Imaging for Retinal Cavernous Hemangioma

      Objective : The aim of this study was to investigate the multimodality imaging features of retinal cavernous hemangiomas (RCHs). Materials and Methods : The clinical data of three patients with RCH were reviewed and the imaging findings were analyzed. Results : The color photographs of the fundus showed bead-like vesicles in the retina. Some vesicles showed plasma erythrocyte separation—with plasma on the top and erythrocytes at the bottom—which was consistently detected as high spontaneous fluorescence on fundus fluorescence angiography. Other vesicles were surrounded by thick walls and fibrous tissue, showing high spontaneous fluorescence, although they did not show any changes on ...

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