1. Articles in category: Ophthalmology

    73-96 of 14095 « 1 2 3 4 5 6 7 ... 586 587 588 »
    1. The effect of conjunctivochalasis detected by anterior segment optical coherence tomography on tear function in an elderly population

      The effect of conjunctivochalasis detected by anterior segment optical coherence tomography on tear function in an elderly population

      Introduction: The aim of this study was to evaluate conjunctivochalasis (CCH) and its relationship with tear meniscus and tear function in an elderly population. Materials and methods: This prospective, observational study included 144 eyes of 144 patients aged >65 years who were referred to our clinic for various reasons. The patients were separated into group 1 including 64 eyes of 64 patients with CCH and group 2 including 80 eyes of 80 patients without CCH. All patients in both groups underwent a full ophthalmological examination, and the presence of CCH, fluorescein tear break-up time (FTBUT) test, Schirmer test, ocular surface ...

      Read Full Article
    2. Peripapillary and Macular Flow Changes in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) by Optical Coherence Tomography Angiography (OCT-A)

      Peripapillary and Macular Flow Changes in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) by Optical Coherence Tomography Angiography (OCT-A)

      Background . To analyze the blood flow changes of radial peripapillary capillaries (RPCs) and macula with time procession in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by optical coherence tomography angiography (OCT-A). Methods . A total of 21 affected eyes and 19 unaffected eyes from 21 NAION patients were included. Assessments of BCVA, CFP, SD-OCT, and OCT-A were performed on NAION patients at enrollment and at 1-2 weeks, 1-2 months, and 3–6 months after enrollment. Measures of the thickness of the peripapillary retinal nerve fiber layer (wRNFL) and macular ganglion cell complex (wGCC) of the whole image in SD-OCT, vessel ...

      Read Full Article
    3. Optical coherence tomography angiography measured area of retinal neovascularization is predictive of treatment response and progression of disease in patients with proliferative diabetic retinopathy

      Optical coherence tomography angiography measured area of retinal neovascularization is predictive of treatment response and progression of disease in patients with proliferative diabetic retinopathy

      Background The purpose of this study was to evaluate the area of retinal neovascularization in patients with treatment-naïve proliferative diabetic retinopathy (PDR) as measured by optical coherence tomography angiography (OCT-A) as a marker of subsequent treatment response after panretinal photocoagulation (PRP), and to examine if this area correlated with area of retinal neovascularization as measured by fluorescein angiography (FA). Methods En face OCT-A scans (4.5 × 4.5 mm) of neovascularizations were obtained at baseline (BL) before PRP and at month (M) 3 and M6 after treatment. Progression of PDR were defined as lesion growth (assessed by ophthalmoscopy and ...

      Read Full Article
    4. A Novel Approach to Quantitative Evaluation of Outer Retinal Lesions Via a New Parameter “Integral” in Spectral Domain Optical Coherence Tomography

      A Novel Approach to Quantitative Evaluation of Outer Retinal Lesions Via a New Parameter “Integral” in Spectral Domain Optical Coherence Tomography

      Purpose : The purpose of this study was to design a new parameter “integral” to quantitatively evaluate the spatial cumulative reflectivity of the outer retinal layers in optical coherence tomography (OCT), and to investigate its role in the detection of outer retinal diseases. Methods : This was a cross-sectional study. Fovea-centered line OCT scans were performed on 60 eyes of 60 healthy volunteers and 44 eyes of 44 patients diagnosed with outer retinal diseases. The integrals of the ellipsoid zone (EZ) and interdigitation zone (IZ) were measured by respectively accumulating the grayscale values of all the pixels within the EZ and IZ ...

      Read Full Article
      Mentions: Fudan University
    5. 8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020”

      8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020”

      More than 50 leading scholars will share their enthusiasm for OCT Angiography and OCT . Highlights of the Congress: scientific and technology session organized by James Fujimoto, Lumbroso Lecture by Larry Yannuzzi, five clinical sessions planned by David Sarraf. Look up the complete program at http://www.apmeetings.com/singolo_evento_sem.php?id=3&lang=en

      Read Full Article
    6. Depth-resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes

      Depth-resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes

      Purpose: Recent developments in optical coherence tomography (OCT) technology enable direct enface visualisation of retinal nerve fibre bundle (RNFB) loss in glaucoma. However, the optimum depth at which to visualise RNFBs across the retina is unknown. We aimed to evaluate the range of depths and optimum depth at which RNFBs can be visualised across the retina in healthy eyes. Methods: The central ± 25° retina of 10 healthy eyes from 10 people aged 57-75 years (median 68.5 years) were imaged with spectral domain OCT. Slab images of maximum axial resolution (4 μm) containing depth-resolved attenuation coefficients were extracted from 0 ...

      Read Full Article
    7. Reasons why OCT Global Circumpapillary Retinal Nerve Fiber Layer Thickness is a Poor Measure of Glaucomatous Progression

      Reasons why OCT Global Circumpapillary Retinal Nerve Fiber Layer Thickness is a Poor Measure of Glaucomatous Progression

      Purpose: To assess the effects of local defects, segmentation errors, and improper image alignment on the performance of the commonly used optical coherence tomography (OCT) measure of progression, that is the change in global (average) circumpapillary retinal nerve fiber layer (cpRNFL) thickness (ΔG). Methods: One hundred fifty eyes suspected of, or with, early glaucoma had OCT circle and cube scans obtained using eye tracking on two occasions at least 1 year apart. Statistical progression was defined by fixed values of ΔG (3-8 um) and quantile regression. For a reference standard, four authors identified 30 eyes as "likely progressed," and 61 ...

      Read Full Article
    8. Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics

      Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics

      A retinal imaging system was designed for full-field (FF) swept-source (SS) optical coherence tomography (OCT) with cellular resolution. The system incorporates a real-time adaptive optics (AO) subsystem and a very high-speed CMOS sensor, and is capable of acquiring volumetric images of the retina at rates up to 1 kHz. While digital aberration correction (DAC) is an attractive potential alternative to AO, it has not yet been shown to provide resolution allowing visualization of cones in the fovea, where early detection of functional deficits is most critical. Here we demonstrate that FF-SS-OCT with hardware AO permits resolution of foveal cones, imaged ...

      Read Full Article
    9. Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT

      Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT

      The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like glaucoma or diabetic retinopathy (DR), might alter the birefringence of the RNFL, which could be used for diagnostic purposes. In this pilot study, we used a state-of-the-art polarization sensitive optical coherence tomography (PS-OCT) system with an integrated retinal tracker to analyze the RNFL birefringence in patients with glaucoma, DR, and in age-matched ...

      Read Full Article
    10. Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography

      Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography

      Purpose: To demonstrate the clinical and research value of a simplified technique enabling alignment of functional microperimetry data with retinal structure imaged by eye-tracked optical coherence tomography (OCT) in eyes with macular disease. Methods: Normal and diseased eyes underwent sequential Spectralis OCT macular raster scans and Macular Integrity Assessment (MAIA) microperimetry using both standard central 10° analysis and custom scan patterns. The microperimetry data were imported into Spectralis research software which was automatically registered to the scanning laser ophthalmoscopy near-infrared reflectance image obtained during OCT acquisition. The OCT B-scans were directly correlated to the microperimetry data so that retina sensitivity ...

      Read Full Article
    11. Gap in capillary perfusion and burden of treatment in branch retinal vein occlusion: A wide-field optical coherence tomography angiography study

      Gap in capillary perfusion and burden of treatment in branch retinal vein occlusion: A wide-field optical coherence tomography angiography study

      Purpose: To evaluate correlations between the burden of anti-vascular endothelial growth factor (VEGF) treatment and microperfusion status in superficial and deep capillary plexus (SCP and DCP) using wide-field optical coherence tomography angiography (OCT-A). Methods: A total 19 eyes with branch retinal vein occlusion (BRVO) were included in this retrospective study. Area of foveal avascular zone (FAZ), capillary non-perfusion area (NPA), vascular density, and perfusion gap were compared between SCP and DCP. Internal areas of 3, 6, 12 mm in diameter around the fovea were analyzed separately. Results: Mean number of injections per months was 0.20 ± 0.12. Number of ...

      Read Full Article
    12. Multimodal imaging of a retinal cavernous hemangioma

      Multimodal imaging of a retinal cavernous hemangioma

      Purpose: We describe the characteristics of an isolated retinal cavernous hemangioma in a young female patient using multimodal imaging. Case description: Fundus examination of the right eye showed a large vascular mass, composed by clusters of dark red and dilated saccular angiomatous formations with superficial whitish fibroglial tissue and hemorrhages, located in the inferonasal peripheral retina, along the vascular arcade. On green-light fundus autofluorescence the lesion appeared hypoautofluorescent, with moderately hyperautofluorescent areas. On multiColor imaging it showed mainly a green pseudocolor, with knobby surface and well-defined irregular margins. Fundus fluorescein angiography showed early hypofluorescence within the tumor mass and late ...

      Read Full Article
    13. Eigenlenses: a new model for full crystalline lens shape representation and its applications

      Eigenlenses: a new model for full crystalline lens shape representation and its applications

      The crystalline lens is an important optical element in the eye, responsible for focusing, and which experiences significant changes throughout life. The shape of the lens is usually studied only in the optical area (central 4 to 6 mm). However, for a great number of applications, a description of the full shape of the crystalline lens is required. We propose a new method for the representation of the full shape of the crystalline lens, constructed from 3-dimensional optical coherence tomography images of 133 isolated crystalline lenses (0-71 y/o), which we have called eigenlenses . The method is shown to be ...

      Read Full Article
    14. OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study

      OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study

      Purpose: To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A). Methods: Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density (VLD) and fractal dimension were computed. VPD of the full-retina OCT-A underneath the RNV was determined to evaluate potential laser-induced changes in vascular perfusion. Results: Fifteen eyes of 13 patients ...

      Read Full Article
    15. Optical Coherence Tomography Angiography Reveals Distinct Retinal Structural and Microvascular Abnormalities in Cerebrovascular Disease

      Optical Coherence Tomography Angiography Reveals Distinct Retinal Structural and Microvascular Abnormalities in Cerebrovascular Disease

      Cerebrovascular disease (CeVD) is one of the leading global causes of death and severe disability. To date, retinal microangiopathy has become a reflection of cerebral microangiopathy, mirroring the vascular pathological modifications in vivo . To evaluate the retinal structure and microvasculature in patients with CeVD, we conducted a cross-sectional study in Zhongshan Ophthalmic Center and Department of Neurology of Third Affiliated Hospital, Sun Yat-sen University using optical coherence tomography angiography (OCTA). CeVD patients ( n = 121; 238 eyes) and healthy controls ( n = 44; 57 eyes) were included in the analysis. The CeVD group showed significant thinning of the peripapillary retinal nerve fiber ...

      Read Full Article
    16. AQP4-IgG and MOG-IgG Related Optic Neuritis-Prevalence, Optical Coherence Tomography Findings, and Visual Outcomes: A Systematic Review and Meta-Analysis

      AQP4-IgG and MOG-IgG Related Optic Neuritis-Prevalence, Optical Coherence Tomography Findings, and Visual Outcomes: A Systematic Review and Meta-Analysis

      Background: Optic neuritis (ON) is a cardinal manifestation of multiple sclerosis (MS), aquaporin-4 (AQP4)-IgG-, and myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease. However, the prevalence of AQP4-IgG seropositivity and MOG-IgG seropositivity in isolated ON is unclear, and studies comparing visual outcomes and optical coherence tomography (OCT)-derived structural retinal measures between MS-ON, AQP4-ON, and MOG-ON eyes are limited by small sample sizes. Objectives: (1) To assess the prevalence of AQP4-IgG and MOG-IgG seropositivity among patients presenting with isolated ON; (2) to compare visual outcomes and OCT measures between AQP4-ON, MOG-ON, and MS-ON eyes. Methods: In this systematic review and meta-analysis ...

      Read Full Article
    17. Accuracy of anterior segment optical coherence tomography for pre-operative localization of insertions of extraocular recti muscles

      Accuracy of anterior segment optical coherence tomography for pre-operative localization of insertions of extraocular recti muscles

      Introduction: To study the accuracy of anterior segment optical coherence tomography (AS-OCT) function of Cirrus HD-OCT 500 (Carl Zeiss Meditec, Dublin, CA) in calculating the insertion of rectus muscles from the limbus in patients undergoing primary squint surgery. Methodology: A prospective, double-masked, observational study was conducted on 128 muscles of 46 patients with strabismus who were planned for strabismus surgery between January 2019 and December 2019. Insertion distance from limbus was measured using AS-OCT function of Cirrus HD-OCT 500 preoperatively. Intraoperative measurements were taken using Castroviejo caliper. A Bland-Altman analysis was performed to determine the agreement between the readings. Results ...

      Read Full Article
    18. Quantitative deep vascular complex analysis of different AMD stages on optical coherence tomography angiography

      Quantitative deep vascular complex analysis of different AMD stages on optical coherence tomography angiography

      Aims: To investigate alterations in deep retinal vascular complex (DVC) in patients with non-neovascular intermediate AMD (iAMD), treatment-naïve quiescent macular neovascularization (qMNV), exudative AMD (eAMD) by means of OCT angiography (OCTA). Methods: Patients with iAMD, qMNV, eAMD and healthy controls presenting in the Department of Ophthalmology of the Centre Hospitalier Intercommunal de Créteil between January 2016 and January 2018, were retrospectively included. 3 × 3-mm OCTA (AngioVue RTVue XR Avanti) perfusion density (PD) of DVC was computed in all groups at baseline and follow up (12.0 ± 1.1 months). Results: A total of 46 eyes of 45 patients ...

      Read Full Article
    19. Early Retinal Changes by OCT Angiography and Multifocal Electroretinography in Diabetes

      Early Retinal Changes by OCT Angiography and Multifocal Electroretinography in Diabetes

      Background: To evaluate the earliest retinal morphological and functional changes in diabetic eyes without or with early signs of diabetic retinopathy (DR). Methods: Twenty-two eyes with no DR (noDR group), 22 eyes with mild DR (DR group), and 18 healthy nondiabetic eyes (controls) were enrolled. All eyes were studied by means of spectral domain optical coherence tomography (OCT), OCT angiography (OCTA), and multifocal electroretinogram (mfERG). Results: A significantly higher number of OCT hyperreflective intraretinal foci (HRF) was found in both noDR and DR groups versus controls, but not between DR groups. The OCTA parameters of the superficial vascular plexus (SVP ...

      Read Full Article
    20. Association of Retinal Nerve Fiber Layer (RNFL) Thickness with Smoking Using Optical Coherence Tomography (OCT) in Pakistani Population

      Association of Retinal Nerve Fiber Layer (RNFL) Thickness with Smoking Using Optical Coherence Tomography (OCT) in Pakistani Population

      Background : Smoking has multisystem effects on human body due to hypoxia and systemic inflammation, which it produces. This contributory effect is observed in ocular tissues as well. The aim of the study was to evaluate retinal nerve fiber layer (RNFL) thickness in healthy individuals with a history of smoking, using optical coherence tomography (OCT). Methods : Patients healthy eyes n=300 were examined. Two groups were made; Group A with history of smoking (n=50) and Group B with no history of smoking (n=250). Subjects with a history of diabetes, hypertension, raised intra ocular pressure (IOP >21 mmHg), any neurological ...

      Read Full Article
    21. Atlas of Anterior Segment Optical Coherence Tomography (Textbook)

      Atlas of Anterior Segment Optical Coherence Tomography (Textbook)

      Atlas of Anterior Segment Optical Coherence Tomography is organized into comprehensive chapters on the following topics: fundamentals, technologies and technological differences among platforms, application of OCT, corneal OCT angiography, as well as case-based chapters. Numerous highly-detailed figures, illustrations and photographs make this an ideal resource for the corneal specialist seeking further instruction on this cutting-edge technology. The case-based chapters include such conditions as bowman dystrophies, trauma, cataract, glaucoma, sclera, refractive surgery, ocular infections, and are structured to facilitate the consultant surgeon by providing practical information applicable to practical cases in their practice.

      Read Full Article
    22. Investigation of the efficacy of an online tool for improving the diagnosis of macular lesions imaged by optical coherence tomography

      Investigation of the efficacy of an online tool for improving the diagnosis of macular lesions imaged by optical coherence tomography

      Purpose: Optical coherence tomography (OCT) is a non-invasive method for diagnosis and monitoring of retinal (typically, macular) conditions. The unfamiliar nature of OCT images can present considerable challenges for some community optometrists. The purpose of this research is to develop and assess the efficacy of a novel internet resource designed to assist optometrists in using OCT for diagnosis of macular disease and patient management. Methods: An online tool (OCTAID) has been designed to assist practitioners in the diagnosis of macular lesions detected by OCT. The effectiveness of OCTAID was evaluated in a randomised controlled trial comparing two groups of practitioners ...

      Read Full Article
    23. Alterations in the Retinal Vascular Network and Structure in MOG Antibody-Associated Disease: An Optical Coherence Tomography Angiography Study

      Alterations in the Retinal Vascular Network and Structure in MOG Antibody-Associated Disease: An Optical Coherence Tomography Angiography Study

      Background: To determine retinal vessel density in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods: Twenty-five patients with MOGAD and 20 healthy participants were enrolled. Patients with MOGAD were divided into myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-positive eyes with a history of optic neuritis (ON; MOG-Ab-ON+ group) or without a history of ON (MOG-Ab-ON- group). Visual function, retinal vessel densities, and thickness were measured. Results: The retinal nerve fiber layer, parafoveal ganglion cell and inner plexiform layers, and vessel densities in the peripapillary and parafoveal areas were significantly decreased in the MOG-Ab-ON+ eyes compared with healthy eyes and MOG-Ab-ON- ...

      Read Full Article
      Mentions: Fudan University
    24. Weakly Supervised Deep Learning Based Optical Coherence Tomography Angiography

      Weakly Supervised Deep Learning Based Optical Coherence Tomography Angiography

      Optical coherence tomography angiography (OCTA) is a promising imaging modality for microvasculature studies. Deep learning networks have been widely applied in the field of OCTA reconstruction, benefiting from its powerful mapping capability among images. However, these existing deep learning-based methods depend on high-quality labels, which are hard to acquire considering imaging hardware limitations and practical data acquisition conditions. In this paper, we proposed an unprecedented weakly supervised deep learning-based pipeline for OCTA reconstruction task, in the absence of high-quality training labels. The proposed pipeline was investigated on an in vivo animal dataset and a human eye dataset by a cross-validation ...

      Read Full Article
    73-96 of 14095 « 1 2 3 4 5 6 7 ... 586 587 588 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (4 articles) UCLA
    2. (4 articles) University of Miami
    3. (3 articles) University College London
    4. (3 articles) The Chinese University of Hong Kong
    5. (3 articles) Fudan University
    6. (2 articles) University of Tokyo
    7. (2 articles) Massachusetts Institute of Technology
    8. (2 articles) LuEsther T. Mertz Retinal Research Center
    9. (2 articles) Duke University
    10. (2 articles) University of Washington
    11. (2 articles) University of Toronto
    12. (2 articles) University of Tsukuba
  4. People in the News

    1. (2 articles) Srinivas R. Sadda
    2. (2 articles) Cynthia A. Toth
    3. (2 articles) K. Bailey Freund
    4. (2 articles) James G. Fujimoto
    5. (2 articles) Pearse A. Keane
    6. (2 articles) Ruikang K. Wang
    7. (2 articles) Yan Li
    8. (2 articles) Michael Pircher
    9. (2 articles) David Huang
    10. (2 articles) Christoph K. Hitzenberger
    11. (1 articles) Johannes F. de Boer
    12. (1 articles) Michael D. Twa
  5. OCT Companies in the News

    1. (6 articles) Optovue
    2. (6 articles) Carl Zeiss Meditec
    3. (5 articles) Heidelberg Engineering
    4. (3 articles) Alcon
    5. (3 articles) Optos
    6. (2 articles) Topcon Medical Systems
    7. (2 articles) Tomey Corporation
    8. (2 articles) Haag-Streit
    9. (1 articles) Leica