1. Articles in category: Ophthalmology

    73-96 of 12388 « 1 2 3 4 5 6 7 ... 515 516 517 »
    1. Topographic changes simulating keratoconus in patients with irregular inferior epithelial thickening documented by anterior segment optical coherence tomography

      Topographic changes simulating keratoconus in patients with irregular inferior epithelial thickening documented by anterior segment optical coherence tomography

      Purpose: To present six patients with keratoconus-like topographic changes due to inferior inhomogenous epithelial thickening, demonstrated by AS-OCT epithelium map. Patients and methods: We present twelve eyes of six patients evaluated in the refractive surgery consultation with Pentacam ® HR Scheimpflug rotating camera system, presenting topographical irregularities suggestive of keratoconus. Slit-lamp examination, best-corrected visual acuity, Scheimpflug tomography and anterior segment optical coherence tomography epithelium map (Optovue ® ) were conducted and analyzed. Results: The mean age was 42 years and the female:male ratio was 2:1. Mean Kmax was 45±2 D. The mean corneal thickness at apex was 560±33 μm ...

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    2. Study results suggest performing OCTs at same time of day

      Study results suggest performing OCTs at same time of day

      Researchers determined that minimum rim width measures on OCT can vary significantly from one 12-hour period to the next, so the test should be conducted at the same time of day to optimize repeatability, they said Laura P. Pardon, OD, MS, FAAO, an American Academy of Optometry Ezell Fellow, shared these study results during an academy-sponsored press conference here at the AAO meeting . “It’s important to understand changes in the optic nerve head throughout the day,” she said at the press conference, so she and her colleagues sought, “to determine repeatability for optic nerve OCT parameters within a given ...

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    3. Authors’ reply to: Using anterior segment optical coherence tomography to compare the smoothness of anterior iris surface between two eyes in unilateral Fuchs’ uveitis syndrome

      Authors’ reply to: Using anterior segment optical coherence tomography to compare the smoothness of anterior iris surface between two eyes in unilateral Fuchs’ uveitis syndrome

      We thank Zarei M et al. for the comments on our article [ 1 ]. Iris changes are well-known features of Fuchs’ uveitis syndrome (FUS). Diffuse iris atrophy without hypochromia is reported as 49% in a large longitudinal study [ 2 ]. However, the decision on diffuse atrophy existence in this study has been made by observation not based on quantitative analysis. The studies that conducted for analysis of iris thickness of FUS quantitatively have shown decreased iris thickness (IT) in the affected eye compared with the healthy fellow eye [ 3 , 4 ]. In our study, we could not have found a statistically significant difference ...

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    4. Ophthalmic imaging apparatus and ophthalmic image processing apparatus

      Ophthalmic imaging apparatus and ophthalmic image processing apparatus

      An ophthalmic imaging apparatus of an embodiment includes a data acquisition unit, a blood vessel enhanced image forming unit, and a blood vessel gradient distribution determination unit. The data acquisition unit is configured to acquire a three dimensional data set of a fundus of a subject's eye using optical coherence tomography (OCT). The blood vessel enhanced image forming unit is configured to form a blood vessel enhanced image based on the three dimensional data set. The blood vessel gradient distribution determination unit is configured to determine a blood vessel gradient distribution that shows gradients of blood vessels at a ...

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    5. Using anterior segment optical coherence tomography to compare the smoothness of anterior iris surface between two eyes in unilateral Fuchs’ uveitis syndrome

      Using anterior segment optical coherence tomography to compare the smoothness of anterior iris surface between two eyes in unilateral Fuchs’ uveitis syndrome

      Dear editor, We read with great interest the article by Ozer et al. [ 1 ] titled “In vivo analysis and comparison of anterior segment structures of both eyes in unilateral Fuchs’ uveitis syndrome”. Using the specular microscope and anterior segment optical coherence tomography (ASOCT), the authors compared corneal endothelial cell density (ECD), iris stromal thickness (IST), iris pigment epithelium optical density (IPE OD), and Schlemm’s canal (SC) measurements in patients having unilateral Fuchs’ uveitis syndrome (FUS). They concluded that, despite significant reduction in IPE OD in temporal side of iris in FUS eyes, the mean IST is not significantly different ...

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    6. Product News: EnFocus OCT fully integrated into the Proveo 8 microscope

      Product News: EnFocus OCT fully integrated into the Proveo 8 microscope

      At the 2019 ESCRS Congress in Paris, Leica Microsystems previewed their EnFocus intraoperative Optical Coherence Tomography (OCT) system, which is built into the stand of the Proveo 8 ophthalmic microscope. This fully integrated solution is designed to enable surgeons to bridge the gap between pre-operative assessment and intraoperative tissue reaction during complex cornea, glaucoma, and retinal surgeries. EnFocus OCT enhances the ophthalmic surgeon’s view, providing cross-sectional images of subsurface ocular tissue details in real-time with ultra-HD resolution. It can help surgeons to overcome uncertainties in moments where they might ask themselves questions such as: Is there residual sub-retinal fluid ...

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      Mentions: Bioptigen Leica
    7. Comparison of angle-to-angle distance using three devices in normal eyes

      Comparison of angle-to-angle distance using three devices in normal eyes

      Purpose To compare the angle-to-angle (ATA) distance, and the repeatability and the reproducibility of these measurements among the three devices. Methods We performed the ATA measurements in 26 healthy subjects using anterior segment optical coherence tomography (CASIA2, Tomey, Japan), the Scheimpflug camera (Pentacam HR, Oculus, Wetzlar, Germany), and the combined Placido-ring corneal topography and Scheimpflug camera (TMS-5, Tomey). We also compared the repeatability and the reproducibility of the ATA measurements among these three devices. Results The ATA in the CASIA2 group was significantly larger than that in the Pentacam group (Bonferroni test, p  = 0.002), or that in the TMS-5 ...

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    8. Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography

      Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography

      Purpose : To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics. Methods : This study used prospective, noncomparative case series, including 21 eyes of 21 healthy individuals. The 6 × 6-mm macular area was imaged repeatedly to obtain two cube image sets. Images from structural OCT (OCT-S) and OCT angiography (OCT-A) were exported. After vessel-like structures segmentation from the inverted black and white OCT-S images and the OCT-A images, both types of images were reconstructed in a 3D model. The volumes of the outer choroid and the ...

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    9. Impact of integrated multiple image averaging on OCT angiography image quality and quantitative parameters

      Impact of integrated multiple image averaging on OCT angiography image quality and quantitative parameters

      Purpose Multiple image averaging (MIA) is a new approach to improve OCT angiography (OCTA) imaging. The aim of this work was to analyze the impact of MIA on image quality and quantitative OCTA parameters. Methods Twenty eyes from 20 healthy volunteers (55.65 ± 14.8 years) were prospectively enrolled. Imaging was performed using two commercially available OCTA devices (Canon OCT HS-100, Optovue AngioVue) using a uniform imaging protocol. Each participant had two single scans of the macula (3 × 3mm, Canon and Optovue) as well as five continuous single scan imaging procedures (3 × 3mm each) using the Canon device. Three out ...

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    10. Assessment of corneal viscoelasticity using elastic wave optical coherence elastography

      Assessment of corneal viscoelasticity using elastic wave optical coherence elastography

      The corneal viscoelasticity have great clinical significance, such as the early diagnosis of keratoconus. In this work, an analysis method which utilized the elastic wave velocity, frequency and energy attenuation to assess the corneal viscoelasticity is presented. Using phase‐resolved optical coherence tomography, the spatial‐temporal displacement map is derived. The phase velocity dispersion curve and center frequency are obtained by transforming the displacement map into the wavenumber‐frequency domain through the 2D Fast Fourier Transform (FFT). The shear modulus is calculated through Rayleigh wave equation using the phase velocity in the high‐frequency. The normalized energy distribution is plotted ...

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    11. Evaluation of foveal avascular zone and capillary plexus in smokers using optical coherence tomography angiography

      Evaluation of foveal avascular zone and capillary plexus in smokers using optical coherence tomography angiography

      Purpose To evaluate the macular microvasculature in smokers in comparison to healthy subjects using optical coherence tomography angiography (OCTA). Methods Fifty chronic, regular smokers and 50 healthy non-smokers, as a control group, were recruited for the study. Foveal avascular zone (FAZ) area (mm 2 ) and vessel density (VD) (%) in the superficial (SCP) and deep capillary plexus (DCP) were evaluated. Results FAZ area was 0.424 ± 0.100 mm 2 in the smoker group and 0.333 ± 0.093 mm 2 in the non-smoking control group ( P = 0.002). The deep foveal VD was 31.76 ± 6.33% in the smoker ...

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    12. Deep learning based noise reduction method for automatic 3D segmentation of the anterior of lamina cribrosa in optical coherence tomography volumetric scans

      Deep learning based noise reduction method for automatic 3D segmentation of the anterior of lamina cribrosa in optical coherence tomography volumetric scans

      A deep-learning (DL) based noise reduction algorithm, in combination with a vessel shadow compensation method and a three-dimensional (3D) segmentation technique, has been developed to achieve, to the authors best knowledge, the first automatic segmentation of the anterior surface of the lamina cribrosa (LC) in volumetric ophthalmic optical coherence tomography (OCT) scans. The present DL-based OCT noise reduction algorithm was trained without the need of noise-free ground truth images by utilizing the latest development in deep learning of de-noising from single noisy images, and was demonstrated to be able to cover more locations in the retina and disease cases of ...

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    13. Optical coherence tomography in people with epilepsy: symmetry and clinical correlations (Thesis)

      Optical coherence tomography in people with epilepsy: symmetry and clinical correlations (Thesis)

      Optical Coherence Tomography (OCT) provides detailed images by assessing the scattering properties of a tissue (1)⁠. OCT is precise and easily repeatable. It is quick to obtain and does not cause any significant discomfort to patients. For these reasons, it is a useful clinical tool to diagnose and monitor many conditions. Peripapillary retinal nerve fibre layer (pRNFL) thickness measured by OCT was recently confirmed as a biomarker of white matter (WM) integrity in various neurological conditions (2)⁠. In epilepsy, retinal thinning is found in people exposed to vigabatrin (3)⁠ but also in people not exposed to this antiepileptic drug (AED ...

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    14. Optical coherence tomography in the diagnosis and follow-up of eye diseases in childhood - a review

      Optical coherence tomography in the diagnosis and follow-up of eye diseases in childhood - a review

      After its development approximately 20 years ago, optical coherence tomography (OCT) has taken an important part in the scientific and clinical work of the ophthalmologist and continues to develop. Using OCT technology in every day practice helps the eye doctors to make clinical diagnoses and follow-up of socially significant diseases like glaucoma, degenerative retinal diseases, and pathology of the macula and optic nerve head, which could be responsible for irreversible decrease or loss of central and/or peripheral vision. Because of the above-mentioned, we aimed to summarize the diagnostic and follow-up possibilities of OCT as an imaging technique for childhood ...

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    15. Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

      Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

      BACKGROUND AND OBJECTIVE: To evaluate the flow characteristics and textural properties of choriocapillaris (CC) on optical coherence tomography angiography in eyes with resolved inflammatory choriocapillaropathies and Vogt-Koyanagi-Harada (VKH) disease. PATIENTS AND METHODS: A cohort of eyes with healed acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and VKH disease were included. A 3 mm × 3 mm OCT angiogram of CC was acquired and graded for flow characteristics and textural properties. RESULTS: This study included 16 patients. Texture was heterogeneous in all eyes in the SC and VKH groups, and in four eyes (40%) in the APMPPE group. Most ...

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    16. Spectral Domain Optical Coherence Tomography Features For Accurate Diagnosis

      Spectral Domain Optical Coherence Tomography Features For Accurate Diagnosis

      UY SDC Abstract In Brief Author Information Article Metrics Purpose: To report a cohort with optic disk pit maculopathy (ODPM) presenting with neurosensory macular detachment that were initially misdiagnosed and mistreated; and to describe structural features on spectral domain optical coherence tomography in misdiagnosed and all other consecutive cases of ODPM. Methods: Multicenter international retrospective cohort study. Participants: 59 eyes from 59 patients with ODPM. Main outcome measures: 1) Proportion of patients with ODPM initially misdiagnosed, inaccurate diagnosis and treatment. 2) Morphologic features on spectral domain optical coherence tomography : other causes of subretinal and/or intraretinal fluid, inner/outer retinoschisis ...

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    17. Preoperative Vitreoretinal Interface Abnormalities On Spectral Domain Optical Coherence Tomography As Risk Factor For Pseudophakic Cystoid Macular Edema After Phacoemulsification

      Preoperative Vitreoretinal Interface Abnormalities On Spectral Domain Optical Coherence Tomography As Risk Factor For Pseudophakic Cystoid Macular Edema After Phacoemulsification

      Purpose: We assessed the role of vitreoretinal interface status in the development of pseudophakic cystoid macular edema (PCME) after cataract surgery. Methods: Prospective cohort study in which 112 patients (112 eyes) scheduled for cataract surgery were selected at random to undergo spectral domain optical coherence tomography (OCT) within 1 week preoperatively and at 1 and 3 months postoperatively. Spectral domain OCT macular images included no vitreoretinal contact, focal and diffuse vitreomacular adhesion , focal and diffuse vitreomacular traction , epiretinal membrane , macular hole, and macular edema. Results: The incidence of PCME was 11.6% (13 eyes), all of them being diagnosed at ...

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    18. OCT-Angiography: Mydriatic phenylephrine and tropicamide do not influence retinal microvasculature in macula and peripapillary region

      OCT-Angiography: Mydriatic phenylephrine and tropicamide do not influence retinal microvasculature in macula and peripapillary region

      Purpose Optical coherence tomography angiography (OCT-A) enables visualization of retinal microcirculation. As a potential influence of mydriatic eye drops on retinal vessel density (VD) was proposed, the purpose of the present study was to investigate an influence of 5% phenylephrine and 0.5% tropicamide on macula and peripapillary VD. Methods 30 eyes of 30 healthy persons were measured by en face OCT-A (Spectralis OCT II, Heidelberg Engineering, Heidelberg). Scans of the macula (12 sectors, region of interest, ROI: 6.10 mm 2 ) and peripapillary region (4 sectors, ROI: 2.67 mm 2 ) were performed before (-) and 30 minutes after application ...

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    19. Application of functional optical coherence tomography angiography in neurovascular research (Thesis)

      Application of functional optical coherence tomography angiography in neurovascular research (Thesis)

      Optical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring backscattered or backreflected light. Its functional extension, OCT angiography (OCTA), analyzes the intrinsic scattering property of the heterogenous tissue bed to extract dynamic blood flow signals to the capillary level without a need of contrast agents. Aside from the commonly known application of OCTA in clinical ophthalmology for imaging the retinal blood flow in human subjects, the technique has recently emerged as a useful tool in pre-clinical neuroscience for imaging cerebral microcirculation and dynamics ...

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    20. Structural and optical coherence tomography angiography in myopic choroidal neovascularization: Agreement with conventional fluorescein angiography

      Structural and optical coherence tomography angiography in myopic choroidal neovascularization: Agreement with conventional fluorescein angiography

      Purpose: To evaluate the agreement between fluorescein angiography and structural optical coherence tomography in diagnosing and monitoring the activity of myopic choroidal neovascularization and to provide a comparative analysis with optical coherence tomography angiography. Methods: Thirteen patients with active myopic choroidal neovascularization were prospectively enrolled. At the baseline, 2-month, and 6-month visits, each patient underwent a complete ophthalmological examination, including best-corrected visual acuity assessment, fundus examination, fluorescein angiography, and optical coherence tomography with structural and angiographic assessment. Sensitivity and specificity for all optical coherence tomography parameters were evaluated taking fluorescein angiography as the reference examination. Results: At the baseline, fluorescein ...

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    21. Pre-, Intra-, and Post-Operative Evaluation of Extraocular Muscle Insertions Using Optical Coherence Tomography: A Comparison of Four Devices

      Pre-, Intra-, and Post-Operative Evaluation of Extraocular Muscle Insertions Using Optical Coherence Tomography: A Comparison of Four Devices

      OCT (optical coherence tomography) is widely used in ophthalmology and pediatric ophthalmology, but limited research has been done on the use of OCT in strabismus. This study investigates the use of different OCT machines to image rectus muscle insertions pre-, intra-, and post-operatively in pediatric strabismus patients. The OCT machines used in the study were a Bioptigen (Leica Microsystems Inc., Buffalo Grove, IL, USA), Spectralis HRA+OCT with Anterior Segment Module (Heidelberg Engineering, Heidelberg, Germany), Visante (Carl Zeiss, Oberkochen, Germany), and Zeiss Rescan 700 (Carl Zeiss, Oberkochen, Germany). Measurements from the machines were compared with the caliper distance measured during ...

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    22. Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Purpose : To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). Methods : Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 × 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm that detects nonperfusion in full-retina OCT slabs was developed, and the percentages of capillary nonperfusion within the total image area were calculated. Retinal arteries and veins were manually traced. Based ...

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    23. Reproducibility of Foveal Avascular Zone and Superficial Macular Retinal Vasculature Measurements in Healthy Eyes Determined by Two Different Scanning Protocols of Optical Coherence Tomography Angiography

      Reproducibility of Foveal Avascular Zone and Superficial Macular Retinal Vasculature Measurements in Healthy Eyes Determined by Two Different Scanning Protocols of Optical Coherence Tomography Angiography

      Purpose: To assess the reproducibility of quantitative measurements of the foveal avascular zone (FAZ) and retinal vasculature determined by different scanning protocols of optical coherence tomography angiography (OCTA) in healthy volunteers. Method: All participants were scanned by two trained operators using an AngioPlex OCTA. Both angiography protocols (6 × 6 mm and 3 × 3 mm) were performed three times on the same eye by operator A and one additional time by operator B. The FAZ area and perimeter, retinal vessel length density (VLD) and perfusion density (PD) of different regions were analysed. Results: Fifty-two eyes from 52 subjects were recruited for ...

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