1. Articles in category: Ophthalmology

    73-96 of 12767 « 1 2 3 4 5 6 7 ... 530 531 532 »
    1. Optical coherence tomographic angiography and ultra-widefield indocyanine green angiography of a choroidal macrovessel

      Optical coherence tomographic angiography and ultra-widefield indocyanine green angiography of a choroidal macrovessel

      Purpose We evaluated a choroidal macrovessel using optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA). Observations A 79-year-old female presented with blurred vision in both eyes and metamorphopsia of the left eye. Mild cataract was noted in both eyes. Color fundus photography of the left eye revealed a red-orange tortuous vessel originating from the fovea and running in an inferior-temporal direction. Enhanced-depth imaging OCT revealed a large caliber choroidal vascular shadow and ambiguous line of the photoreceptor and retinal pigment epithelium layers. OCTA demonstrated a serpentine-shaped choroidal vessel. This anomalous vessel was seen by early phase ICGA as ...

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    2. Malapposition of graft-host interface after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK): an optical coherence tomography study

      Malapposition of graft-host interface after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK): an optical coherence tomography study

      Backgroud Previous studies of internal graft-host malappositions have not dealt with the precise ways in which each malapposition affected post-penetrating keratoplasty (post-PK) visual outcomes. In this study, we reviewed our post-PK and post-deep anterior lamellar keratoplasty (post-DALK) keratoconic patients and used anterior segment optical coherence tomography (AS-OCT) to evaluate the associations between graft-host interface (GHI) characteristics and visual outcomes. Methods Novel GHI metrics included: mean graft-host touch (GHT), total prevalence of malapposition proportion (Pm), frequency of apposition (F), size of malapposition (Sm), junctional graft thickness (Tg), junctional host thickness (Th) and the absolute value of difference between Tg and Th ...

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      Mentions: Fudan University
    3. Choroidoscleral Interface Irregularity Index: A novel optical coherence tomography-based parameter in patients with epiretinal membrane

      Choroidoscleral Interface Irregularity Index: A novel optical coherence tomography-based parameter in patients with epiretinal membrane

      This study aimed to assess the regularity of the choroidoscleral interface (CSI) using a novel parameter, CSI irregularity index, before and after epiretinal membrane (ERM) surgery. This study included 36 patients with idiopathic ERM who underwent pars plana vitrectomy and ERM removal. All subjects underwent ocular examinations at baseline and at 1, 2, 4, and 6 months after surgery. The regular contour of the CSI was found in 14 patients (38.9%); mean CSI irregularity index was 14.84 ± 11.01 in this group. The irregular contour of the CSI was found in 22 patients (61.1%); mean CSI irregularity ...

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    4. Evaluation of macular thickness and volume tested by optical coherence tomography as biomarkers for Alzheimer’s disease in a memory clinic

      Evaluation of macular thickness and volume tested by optical coherence tomography as biomarkers for Alzheimer’s disease in a memory clinic

      Building on previous studies that report thinning of the macula in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) patients, the use of optical coherence tomography (OCT) has been proposed as a potential biomarker for AD. However, other studies contradict these results. A total of 930 participants (414 cognitively healthy people, 192 with probable amnestic MCI, and 324 probable AD patients) from a memory clinic were consecutively included in this study and underwent a spectral domain OCT scan (Maestro, Topcon) to assess total macular volume and thickness. Macular width measurements were also taken in several subregions (central, inner, and ...

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    5. Fundus autofluorescence, spectral‐domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model

      Fundus autofluorescence, spectral‐domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model

      Stargardt disease (STGD1), known as inherited retinal dystrophy, is caused by ABCA4 mutations. The pigmented Abca4 −/− mouse strain only reflects the early stage of STGD1 since it is devoid of retinal degeneration. This blue light‐illuminated pigmented Abca4 −/− mouse model presented retinal pigment epithelium (RPE) and photoreceptor degeneration which was similar to the advanced STGD1 phenotype. In contrast, wild‐type mice showed no RPE degeneration after blue light illumination. In Abca4 −/− mice, the acute blue light diminished the mean autofluorescence (AF) intensity in both fundus short‐wavelength autofluorescence (SW‐AF) and near‐infrared autofluorescence (NIR‐AF) modalities correlating with reduced ...

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    6. Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in normal rats by optical coherence tomography

      Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in normal rats by optical coherence tomography

      Gene therapy has been proposed as a feasible strategy for RGC survival and optic nerve regeneration. Some preclinical and clinical studies revealed intraocular inflammation after intravitreal injection of adeno-associated virus (AAV) by slit-lamp or indirect ophthalmoscope. Here we evaluate the longitudinal profile of immediate inflammatory responses after AAV2 injection in rat retina and vitreous body by optical coherence tomography (OCT). Adult Fischer F344 rats were intravitreally injected once with saline, AAV2 or zymosan. Retinal thickness and cell infiltration were recorded by OCT longitudinally for 2 months and verified by histological analysis. The transduction rate of single intravitreal AAV2 injection was ...

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    7. University of Illinois at Chicago Receives NIH Grantfor Differential Artery-Vein Analysis in OCT Angiography for Objective Classification of Diabetic Retinopathy

      University of Illinois at Chicago Receives NIH Grantfor Differential Artery-Vein Analysis in OCT Angiography for Objective Classification of Diabetic Retinopathy

      University of Illinois at Chicago Receives a 2020 NIH Grant for $362,544 for Differential Artery-Vein Analysis in OCT Angiography for Objective Classification of Diabetic Retinopathy. The principal investigator is Xincheng Yao. Below is a summary of the proposed work. This project aims to establish differential artery-vein analysis in optical coherence tomography angiography (OCTA), and to validate comprehensive OCTA features for automated classification of diabetic retinopathy (DR). Early detection, prompt intervention, and reliable assessment of treatment outcomes are essential to prevent irreversible visual loss from DR. It is known that DR can target arteries and veins differently. Therefore, differential artery-vein ...

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    8. UCLA Receives NIH Grant for Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies

      UCLA Receives NIH Grant for Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies

      University of California at Los Angeles Receives a 2020 NIH Grant for $249,063 for Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies. The principal investigator is Irena Tsui. Below is a summary of the proposed work. This application requests funding for a project to improve maternal fetal healthcare using retinal pictures called optical coherence tomography angiography. Pregnancy is a complex process that can lead to complications such as preterm birth and preeclampsia. Preterm birth occurs in about 1 out of 10 pregnancies and is increasing due to increasing rates of in vitro fertilization, advanced maternal age, and ...

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    9. UCLA Receives NIH Grant for Vitreoretinal Surgery via Robotic Microsurgical System with Imaging Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      UCLA Receives NIH Grant for Vitreoretinal Surgery via Robotic Microsurgical System with Imaging Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      University of California at Los Angeles Receives a 2020 NIH Grant for $429,489 for Vitreoretinal Surgery via Robotic Microsurgical System with Imaging Guidance, Force Feedback, Virtual Fixture, and Augmented Reality. The principal investigator is Jean-Pierre Hubschman. Below is a summary of the proposed work. The aims of the present proposal are to extend our work with the Intraocular Robotic Interventional and Surgical System (IRISS) and augment it for teleoperated vitreoretinal surgery. Although novel technologies such as intraoperative optical coherence tomography (i-OCT) have been developed, vitreoretinal surgeons still lack critical information during surgery (e.g., the distance between pre-retinal membrane ...

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    10. Duke University Receives NIH Grant for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children

      Duke University Receives NIH Grant for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children

      Duke University Receives a 2020 NIH Grant for $192,944 for Handheld Portable Adaptive Optics optical Coherence Tomography for Imaging in Young Children. The principal investigator is Sina Farsiu . Below is a summary of the proposed work. Eye diseases in young children, if not detected and treated early, can lead to serious vision loss and even blindness. We have pioneered development of handheld spectral domain optical coherence tomography (HH- SDOCT) imaging systems to provide 3-D visualization of intra-retinal structures. Our previous studies based on HH-SDOCT of neonatal retina have already provided unique and previously unseen information about disease progression in ...

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    11. Comparison of corneal thickness in patients with dry eye disease using the Pentacam rotating Scheimpflug camera and anterior segment optical coherence tomography

      Comparison of corneal thickness in patients with dry eye disease using the Pentacam rotating Scheimpflug camera and anterior segment optical coherence tomography

      The purpose of this study was to compare central corneal thickness, thinnest corneal thickness, and the thinnest point of the cornea between Pentacam and anterior segment optical coherence tomography (ASOCT) in patients with dry eye disease (DED). This cross-sectional study included 195 participants between November 2015–June 2017. DED was diagnosed using the Asia Dry Eye Society criteria and further divided into mild and severe DED based on kerato-conjunctival vital staining. Central corneal thickness, thinnest corneal thickness, and the thinnest point of the cornea measured by Pentacam and ASOCT were compared, and Pearson’s correlation coefficients were estimated. The differences ...

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    12. Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Acucela Inc. (“Acucela”), a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596), announced today that the company was invited to meet with NASA and the Translational Research Institute for Space Health (TRISH) *1 to present on January 30, 2020 the status of its Swept Source-OCT *2 (“SS-OCT”) device being developed for NASA’s Deep Space missions. The purpose of the meeting was to review and discuss progress of this Phase 1 project with the engineers, basic and medical scientists and program managers from NASA and TRISH. Additionally, a demonstration of the Phase 1 device ...

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    13. Multimodal Imaging Approach for the Diagnosis of a Challenging Case of Bilateral Chronic Central Serous Retinopathy

      Multimodal Imaging Approach for the Diagnosis of a Challenging Case of Bilateral Chronic Central Serous Retinopathy

      Central serous retinopathy is one of relatively common clinical conditions, it is an idiopathic disorder characterized by a localized serous detachment of the sensory retina at the macula due leakage from the choriocapillaris through focal or diffuse retinal pigment epithelial defects. Usually affects the middle age people. Risk factors include type A personality, use of systemic steroids, stress, pregnancy and autoimmune diseases. The acute course of the disease (ACSR) usually spontaneously resolved within 3-6 months in 80% of cases, while the chronic course (CSCR) lasting more than 12 months. Multimodal new imaging techniques like Swept Source OCT (SS-OCT), FAF (Fundus ...

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    14. Comparison of Retinal Vascular Structure in Eyes With and Without Amblyopia by Optical Coherence Tomography Angiography

      Comparison of Retinal Vascular Structure in Eyes With and Without Amblyopia by Optical Coherence Tomography Angiography

      PURPOSE: To evaluate the retinal vascular structure in amblyopic eyes by optical coherence tomography angiography (OCTA). METHODS: Thirty-seven eyes of 37 patients with anisometric amblyopia were compared with 37 eyes of 37 age- and gender-matched control subjects by OCTA in terms of superficial capillary plexus vessel density, deep capillary plexus vessel density, and foveal avascular zone. RESULTS: The mean age was 12 ± 4.2 years in patients with amblyopia and 13 ± 6.1 years in individuals without amblyopia. Foveal superficial capillary plexus vessel densities were 20.49% ± 3.27%, 19.70% ± 3.82%, and 19.96% ± 3.84%, and parafoveal ...

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    15. DIAGNOSTIC CHARACTERISTICS OF POLYPOIDAL CHOROIDAL VASCULOPATHY BASED ON B-SCAN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ITS INTERRATER AGREEMENT COMPARED WITH INDOCYANINE GREEN ANGIOGRAPHY

      DIAGNOSTIC CHARACTERISTICS OF POLYPOIDAL CHOROIDAL VASCULOPATHY BASED ON B-SCAN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ITS INTERRATER AGREEMENT COMPARED WITH INDOCYANINE GREEN ANGIOGRAPHY

      Purpose: To examine the characteristics of polypoidal choroidal vasculopathy using B-scan optical coherence tomography angiography (OCTA), and determine the diagnostic criteria of polypoidal choroidal vasculopathy based on OCTA. Methods: This retrospective case series included patients diagnosed with treatment-naïve polypoidal choroidal vasculopathy who underwent indocyanine green angiography (ICGA) and swept-source OCTA at baseline. We compared the characteristics of the polyps detected using B-scan OCTA and ICGA. Then, the diagnostic concordance of each polypoidal lesion between ICGA and OCTA was evaluated. Results: Among 54 eyes of 52 patients, all 54 eyes showed flow signals indicating polyps on both ICGA and B-scan ...

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    16. MASSIVE RETINAL NEOVASCULARIZATION IN VON HIPPEL–LINDAU DISEASE ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR, VITRECTOMY, IMMUNOHISTOCHEMISTRY, AND OPTICAL COHERENCE TOMOGRAPHY FEATURES

      MASSIVE RETINAL NEOVASCULARIZATION IN VON HIPPEL–LINDAU DISEASE ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR, VITRECTOMY, IMMUNOHISTOCHEMISTRY, AND OPTICAL COHERENCE TOMOGRAPHY FEATURES

      Purpose: To report a rare presentation of ocular von Hippel–Lindau disease associated with a massive epiretinal vascular proliferation over the macula removed by vitrectomy and submitted to histological analysis. Methods: Interventional case report. Results: A 13-year-old woman with von Hippel–Lindau disease reported progressive visual loss in the right eye over the preceding 6 months. Best-corrected visual acuity was 20/100 in the right eye. Fundoscopy showed retinal neovascularization (RNV) with macular traction and a small superotemporal hemangioblastoma. Spectral-domain optical coherence tomography confirmed increased macular thickness and macular traction secondary to RNV. Bevacizumab was injected intravitreally, resulting in partial ...

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    17. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF FOCAL CHOROIDAL EXCAVATION AND THE CHOROIDAL STROMA VARIATIONS WITH OCCURRENCE OF EXCAVATION

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF FOCAL CHOROIDAL EXCAVATION AND THE CHOROIDAL STROMA VARIATIONS WITH OCCURRENCE OF EXCAVATION

      Purpose: To describe retinal and choroidal vascular changes and choroidal stroma variations occurring in focal choroidal excavation (FCE). Methods: Study design was a cross-sectional case series. Consecutive patients affected by FCE and healthy controls were recruited. All patients underwent complete ophthalmologic assessment and multimodal imaging, including structural optical coherence tomography and optical coherence tomography angiography. Choroidal thickness and stromal index were calculated from structural optical coherence tomography images. Moreover, we measured vessel density values of superficial capillary plexus, deep capillary plexus, and choriocapillaris at the level of the macula. Results: Twenty-two patients (28 eyes; mean age 57.2 ± 16.4 ...

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    18. Diagnostic Ability of Optical Coherence Tomography Angiography Macula Vessel Density for the Diagnosis of Glaucoma Using Difference Scan Sizes

      Diagnostic Ability of Optical Coherence Tomography Angiography Macula Vessel Density for the Diagnosis of Glaucoma Using Difference Scan Sizes

      Précis: There is diagnostic information in the outer region of OCTA macula scans not available in the inner region, and this information is especially useful in the early stages of glaucoma . Purpose: To evaluate the diagnostic accuracy of 3×3▒mm 2 and 6×6▒mm 2 macula OCT-A scans for classifying healthy, mild glaucoma , and moderate to severe glaucoma eyes. Methods: Participants enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS) with good quality 3×3▒mm 2 and 6×6▒mm 2 OCT-A images of the macula (AngioVue; Optovue, Freemont, CA) acquired on the same day were ...

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    19. Retinal Capillary Plexus Pattern and Density from Fovea to Periphery Measured in Healthy Eyes with Swept-Source Optical Coherence Tomography Angiography

      Retinal Capillary Plexus Pattern and Density from Fovea to Periphery Measured in Healthy Eyes with Swept-Source Optical Coherence Tomography Angiography

      Optical coherence tomography angiography is evolving towards wider fields of view. As single widefield acquisitions have a lower resolution, preventing an accurate segmentation of vascular plexuses in the periphery, we examined the retinal vascularisation from the macula to the periphery in all retinal quadrants, using 3 × 3-mm volume scans, to obtain montages with sufficient image resolution up to 11 mm from the foveal centre. Images were qualitatively and quantitatively analysed, using C- and B-scan approaches to calculate the capillary density (CD) and the interplexus distance (IPD). Three vascular plexuses ( i.e ., superficial vascular plexus: SVP, intermediate capillary plexus: ICP, and ...

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      Mentions: ESPCI ParisTech
    20. Multimodal imaging characteristics of congenital grouped hyper‐ and hypo‐pigmented fundus lesions

      Multimodal imaging characteristics of congenital grouped hyper‐ and hypo‐pigmented fundus lesions

      Background The imaging characteristics of congenital grouped pigmentation of the retinal pigment epithelium (CGP‐RPE) and its non‐pigmented variant – grouped congenital albinotic retinal pigment epithelial spots (GCARPES) are poorly defined in the literature. Our case series reports their multimodal imaging characteristics across a spectrum of presentations. Methods A retrospective review of patient records was conducted on patients seen at the Centre for Eye Health between January and December 2016. The multimodal imaging findings across four cases is described using optical coherence tomography (OCT), infrared imaging, ultra‐widefield imaging, fundus photography and fundus autofluorescence (FAF). Results Case 1 is a ...

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    21. Assessing the Impact of En Face Retinal Nerve Fiber Layer Imaging on Clinical Decision Making for Glaucoma Suspects

      Assessing the Impact of En Face Retinal Nerve Fiber Layer Imaging on Clinical Decision Making for Glaucoma Suspects

      SIGNIFICANCE Assessing and managing glaucoma are a complicated process in which experience plays a key role in decision making. Although advanced glaucoma is more easily diagnosed, patients with early glaucoma or who present with suspicious findings are more complicated. A need to aid clinicians in the decision-making process exists. PURPOSE The purpose of this study was to assess the impact of en face ocular coherence tomography images to clinical decision making when added to standard presentations of circumpapillary retinal nerve fiber layer thickness and automated perimetry. METHODS Thirty participants from two centers presenting either as a glaucoma suspect or for ...

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    22. Assessing Corneal Speckle in Optical Coherence Tomography: A New Look at Glaucomatous Eyes

      Assessing Corneal Speckle in Optical Coherence Tomography: A New Look at Glaucomatous Eyes

      SIGNIFICANCE Optical coherence tomography speckle is used here in an unconventional way as the indirect source of information on tissue microstructure. The study reveals that the corneal speckle of glaucoma suspects has a similar relationship between the parameters of scattering exhibited in glaucoma patients. PURPOSE The purpose of this study was to evaluate the potential of optical coherence tomography imaging of the cornea in early diagnosis of glaucoma. METHODS Corneas of 64 subjects of three groups, including 18 primary open-angle glaucoma patients, 24 glaucoma suspects with normal levels of IOP and uncompromised visual field, and 22 age-matched controls, were imaged ...

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    23. Using Anterior Segment Optical Coherence Tomography to Assess Angle Anatomy in Patients with Neurofibromatosis Type 1

      Using Anterior Segment Optical Coherence Tomography to Assess Angle Anatomy in Patients with Neurofibromatosis Type 1

      SIGNIFICANCE Lisch nodules have been identified in more than 90% of patients 16 years or older with neurofibromatosis type 1 (NF1). According to our hypothesis, the presence of Lisch nodules in patients with NF1 might affect the anterior chamber angle (ACA) parameters. PURPOSE The aim of this study was to evaluate the anterior segment angle parameters using anterior segment optical coherence tomography in patients with NF1. METHODS A total of 42 eyes from 21 patients with NF1 (study group) and 42 eyes from 21 age- and sex-matched healthy individuals (control group) were included in this study. Angle opening distance at ...

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