1. Articles in category: Ophthalmology

    73-96 of 12918 « 1 2 3 4 5 6 7 ... 537 538 539 »
    1. TOPOGRAPHIC OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION SHOWS LIMITED ELLIPSOID ZONE RECOVERY IN MILD HYDROXYCHLOROQUINE RETINOPATHY

      TOPOGRAPHIC OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION SHOWS LIMITED ELLIPSOID ZONE RECOVERY IN MILD HYDROXYCHLOROQUINE RETINOPATHY

      urpose: Optical coherence tomography (OCT) cross-sections have shown limited ellipsoid zone (EZ) improvement in mild hydroxychloroquine (HCQ) retinopathy within a few years after drug cessation. However, the extent, functional significance, and stability of such changes over time remain unclear. Methods: We created en face EZ maps using automated pixel-by-pixel segmentation for four patients with early-moderate HCQ toxicity followed for 6-8 years after drug cessation. These maps were compared with OCT cross-sections, fundus autofluorescence, and automated 10-2 visual fields. Results: One patient had no EZ line loss; one had stable EZ loss throughout follow-up; two showed 30 to 40% reduction in ...

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    2. Comparison of composite and segmental methods for acquiring optical axial length with swept-source optical coherence tomography

      Comparison of composite and segmental methods for acquiring optical axial length with swept-source optical coherence tomography

      This study compared the optical axial length (AL) obtained by composite and segmental methods using swept-source optical coherence tomography (SS-OCT) devices, and demonstrated its effects on the post-operative refractive errors (RE) one month after cataract surgery. Conventional AL measured with the composite method used the mean refractive index. The segmented-AL method used individual refractive indices for each ocular medium. The composite AL (24.52 ± 2.03 mm) was significantly longer ( P  < 0.001) than the segmented AL (24.49 ± 1.97 mm) among a total of 374 eyes of 374 patients. Bland–Altman analysis revealed a negative proportional bias for ...

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      Mentions: Osaka University
    3. Differentiation of Diabetic Status Using Statistical and Machine Learning Techniques on Optical Coherence Tomography Angiography Images

      Differentiation of Diabetic Status Using Statistical and Machine Learning Techniques on Optical Coherence Tomography Angiography Images

      Purpose : To investigate the potential of statistical and machine learning approaches to determine the diabetic status of patients from optical coherence tomography angiography (OCT-A) images. Methods : This was a retrospective cross-sectional observational study based at Manchester Royal Eye Hospital, United Kingdom. OCT-A scans were sequentially selected from one eye of each of 182 patients who were either not diabetic, diabetic without retinopathy, or diabetic with retinopathy requiring hospital follow-up. Eligible images were analyzed by expert purpose-built automated algorithms to calculate clinically relevant outcome measures. These were used in turn as inputs to machine learning and statistical procedures to derive algorithms ...

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    4. Intraoperative Optical Coherence Tomography–Assisted Descemet Membrane Endothelial Keratoplasty: Toward More Efficient, Safer Surgery

      Intraoperative Optical Coherence Tomography–Assisted Descemet Membrane Endothelial Keratoplasty: Toward More Efficient, Safer Surgery

      Purpose: To evaluate the clinical value of intraoperative optical coherence tomography (iOCT) and prolonged overpressure in Descemet membrane endothelial keratoplasty for surgical safety, efficiency, and outcome. Methods: All Descemet membrane endothelial keratoplasties performed by the same surgeon from November 2016 through April 2018 at the University Medical Center Utrecht were included, including 6 months of follow-up. The primary outcome was the prevalence of adverse events, and the secondary outcomes included critical decision-making and surgery time. Surgeries that included prolonged (ca. 12 minutes) overpressurization of the globe were classified as group 1, and those without prolonged overpressurization of the globe were ...

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    5. Spectral domain optical coherence tomography classification of diabetic macular edema: a new proposal to clinical practice

      Spectral domain optical coherence tomography classification of diabetic macular edema: a new proposal to clinical practice

      Purpose To classify the types of diabetic macular edema (DME) and evaluate its morphological features on spectral domain optical coherence tomography (SD-OCT) and determine correlations between visual acuity and OCT findings. Methods We assessed 406 eyes of 309 patients with a diagnosis of DME retrospectively. Three types based on SD-OCT were identified: diffuse macular edema, cystoid macular edema, and cystoid degeneration. Morphological features such as serous macular detachment (SMD), vitreomacular interface abnormalities (VMAI), hard exudates, photoreceptor status, and correlations between visual acuity and those morphological features were also evaluated by SD-OCT. Results The most common type of DME was cystoid ...

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    6. Evaluation of meridional scans for angle closure assessment with anterior segment swept-source optical coherence tomography

      Evaluation of meridional scans for angle closure assessment with anterior segment swept-source optical coherence tomography

      Background/aims As swept-source optical coherence tomography (SS-OCT) simultaneously obtains 128 meridional scans, it is important to identify which scans are playing the main role in classifying gonioscopic angle closure to simplify the analysis. We aimed to evaluate the diagnostic performance of every meridional scan in its ability to detect gonioscopic angle closure. Methods Observational study with 2027 phakic subjects consecutively recruited from a community polyclinic. Gonioscopy and SS-OCT were performed. Gonioscopic angle closure was defined as non-visibility of the posterior trabecular meshwork in ≥180° of the angle, while SS-OCT was defined as iridotrabecular contact anterior to the scleral spur ...

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    7. Full range line-field optical coherence tomography for high-accuracy measurements of optical lens

      Full range line-field optical coherence tomography for high-accuracy measurements of optical lens

      A full range line-field Fourier domain optical coherence tomography system (LF-FDOCT) with an accuracy at nanoscale was proposed for high-accuracy measurements of optical lens surface profile. The line-field surface curve information of optical lens could be obtained in one measurement which does not need point-by-point scanning used in traditional one-dimensional FDOCT system. The measurement accuracy of surface profile curve could be improved from micrometer scale to nanoscale by applying spectral centre correction method (SCCM) to the complex spectral interferogram. The corrected five phase shifting (CFPS) method was employed to eliminate the complexconjugate artifacts and the polychromatic error. Numerical simulation and ...

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    8. Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus

      Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus

      Purpose : To investigate the clinical significance of the changes in the macular microvasculature in patients with diabetes mellitus type 2 without diabetic retinopathy. Methods : Fifty-five patients with diabetes mellitus type 2 without diabetic retinopathy and 48 healthy individuals were enrolled in a prospective cross-sectional study. We identified the changes of optical coherence tomography angiography parameters (foveal avascular zone [FAZ] area and circularity, vessel density, and perfusion index) of the 6 × 6-mm macular scan. Correlation and multiple regression analyses were performed between optical coherence tomography angiography parameters and previously known diabetes mellitus type 2-related demographic and systemic characteristics, and serum biochemical ...

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    9. Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography

      Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography

      Purpose To study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using swept-source optical coherence tomography angiography (SS-OCTA). Methods Patients with high myopia (≥ − 6D; axial length ≥ 26.5 mm), moderate myopia (≥ − 3D, < − 6D), and age-matched healthy subjects presenting to the Shanghai General Hospital and Doheny-UCLA Eye Centers were enrolled in this prospective, multicenter study. Any subjects with evidence of macular abnormalities suggestive of pathologic myopia were excluded. SS-OCTA at both sites was performed using a Zeiss PLEX Elite instrument with a 6 × 6 mm scan pattern centered on the fovea. Two repeated volume scans were acquired for ...

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    10. Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography

      Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography

      Background To measure the crystalline lens tilt in eyes with various degrees of myopia before cataract surgery using swept-source optical coherence tomography (SS-OCT). Methods We used SS-OCT (IOLMaster 700) to scan 131 emmetropic eyes (axial length < 24.5 mm), 25 mild/moderate myopic eyes (axial length 24.5–26 mm), and 123 high myopic eyes (52, 29, and 42 eyes with axial lengths of 26–28, 28–30, and > 30 mm, respectively) as part of the routine preoperative examination before cataract surgery. SS-OCT involved B-scans along six meridians. The data were analyzed to assess the magnitude and orientation of the ...

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    11. Diversity in optical coherence tomography normative databases: moving beyond race

      Diversity in optical coherence tomography normative databases: moving beyond race

      Normative databases of optical coherence tomography (OCT) metrics, such as retinal nerve fiber layer (RNFL) and macular thickness, are critical to clinical use of OCT imaging. In order to accurately represent the range of normal variation in patient populations, these normative databases must themselves be adequately diverse. Thus far, diversity in OCT normative databases has largely been defined as racial diversity. However, this has largely been based on self-reported “race,” which is inconsistent and generally not scientifically rigorous as a form of categorization. Moreover, there is a great deal of variation even within any single racial group, suggesting that other ...

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    12. Integrated device for ophthalmology

      Integrated device for ophthalmology

      A device (100) for ophthalmic radiation is provided. The device comprises a radiation interface (102), an optical branch coupler (104), and a plurality of ophthalmic units (106, 108, 110, 112). The radiation interface is adapted to at least one of output and capture radiation on an optical path (124). The optical path is directable towards a patient's eye. The optical branch coupler is adapted to couple output radiation from a plurality of optical branches (118, 119, 120, 122, 123) into the optical path and to couple captured radiation from the optical path into the optical branches. The captured radiation ...

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    13. Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography

      Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography

      Purpose: To quantify and assess the reproducibility of the corneal stromal thickness profiles captured by the SD-OCT. Secondly, we correlated the zonal thicknesses to the age, gender and axial length. Methods: We included 227 normal eyes of 227 patients with a maximum hypermetropia of +5 and myopia of – 6 diopters (D). Subjects with an intraocular pressure exceeding 22 mm Hg, evidence of cataract formation, history of ophthalmic surgery or disease were excluded. Lastly, reproducibility was evaluated in a subset of 50 participants by means of an identical scan protocol repeated by 2 different OCT operators. Results: Stromal values were consistently ...

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    14. Plume Sign in the Deturgescence of Macular Cysts – A Novel OCT Finding

      Plume Sign in the Deturgescence of Macular Cysts – A Novel OCT Finding

      Aim: To describe a novel OCT finding called “Plume sign” in macular cysts. Methods: Case records of five cases were retrospectively reviewed. Their case history and imaging findings on spectral domain optical coherence tomography (SD-OCT, Spectralis, Heidelberg, Germany) have been described. Results: We observed five cases which had a solitary cyst foveal or parafoveal in location, was unique due to the presence of a plume-shaped internal substance, was treated with topical NSAIDs and was associated with good visual outcomes. We observed three cardinal events; firstly, retinal thickening followed by the formation of a foveal or parafoveal solitary cyst. Secondly, a ...

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    15. OCT motion contrast acquisition method and optical coherence tomography device

      OCT motion contrast acquisition method and optical coherence tomography device

      An OCT motion contrast data acquisition method using an optical coherence tomography device includes: controlling an optical scanner for scanning measurement light on a test subject; performing a first scanning control for obtaining a first OCT signal group including at least four temporally different OCT signals at a same scanning position; performing a second scanning control for obtaining a second OCT signal group including at least four temporally different OCT signals at the same scanning position; obtaining first motion contrast data based on the first OCT signal group obtained in the first scanning control; obtaining second motion contrast data based ...

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      Mentions: Nidek
    16. ZEISS Medical Technology Announces Changes in Ophthalmic Devices Executive Leadership

      ZEISS Medical Technology Announces Changes in Ophthalmic Devices Executive Leadership

      Effective 1 May 2020, Jim Mazzo will retire from his position as President Ophthalmic Devices and Head of the Ophthalmic Devices Strategic Business Unit for ZEISS. He will continue to support ZEISS as an advisor. With over forty years in the ophthalmic industry, Jim has successfully transformed ZEISS Global Ophthalmic Devices as the number two industry leader in Ophthalmology by creating a strong customer focused organization within his three plus years with ZEISS. "I am very proud of what we have accomplished for customers and employees and pleased to hand over responsibility to Euan and the team. With this team ...

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    17. Optical Coherence Tomography Angiography of Idiopathic Foveal Hypoplasia and Its Correlation With Visual Acuity

      Optical Coherence Tomography Angiography of Idiopathic Foveal Hypoplasia and Its Correlation With Visual Acuity

      SIGNIFICANCE Foveal hypoplasia is described clinically by the absence of a foveal pit and subsequent reduction in visual acuity. Optical coherence tomography angiography provides precise segmentation of the retinal vascular supply demonstrating the vascular perfusion in affected patients. Preservation of perfusion is linked to visual acuity and function. PURPOSE This case report describes a patient with foveal hypoplasia and preservation of visual acuity with preserved retinal capillary density of the superficial and deep capillary plexuses on optical coherence tomography angiography. In addition, the diagnostic findings of foveal hypoplasia as seen on optical coherence tomography angiography will be described. CASE REPORT ...

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    18. Cylite receives ISO 13485 Certification

      Cylite receives ISO 13485 Certification

      Cylite Pty Ltd, a developer and manufacturer of 4 th Generation OCT systems for Ophthalmology and Optometry, is pleased to announce that it has been awarded International Organization for Standardization (ISO) 13485:2016 certification for medical device quality management systems (QMS) following review by BSI. ISO 13485:2016 is an internationally recognized quality standard specific to the medical device industry. ISO 13485 certification affirms to Cylite’s patients and partners that the company is providing the best quality management systems and regulatory compliance for its 4 th generation OCT platform. Yameena Ratnayake, Cylite’s Quality Manager commented,” We are very ...

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      Mentions: Cylite
    19. The Role of Optical Coherence Tomography Signal Strength in the Diagnosis and Follow-up of Patients with Posterior Capsular Opacification Treated with Nd:YAG Laser Capsulotomy

      The Role of Optical Coherence Tomography Signal Strength in the Diagnosis and Follow-up of Patients with Posterior Capsular Opacification Treated with Nd:YAG Laser Capsulotomy

      Objectives: To investigate the relationship between optical coherence tomography (OCT) signal strength (SS) and visual acuity in patients with posterior capsule opacification (PCO) and evaluate the effect of PCO on retinal thickness measurements. Materials and Methods: Forty-one eyes of 35 patients who were diagnosed with PCO were included in the study. Patients with any anterior or posterior segment pathology other than PCO were excluded. After ophthalmologic examination, pupil dilation was induced using 0.5% tropicamide and OCT images were acquired. The assessment was repeated 1 month after Nd:YAG laser capsulotomy and postoperative values were compared with baseline values. Results ...

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    20. Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems

      Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems

      Optical tomographic cross-sectional images of biological samples were made possible by interferometric imaging techniques such as Optical Coherence Tomography (OCT) [1, 2, 3]. Owing to its unprecedented view of the sample, OCT has become a gold standard, namely for human retinal imaging in the clinical environment. In this Letter, we present Optical Incoherence Tomography (OIT): a completely digital method extending the possibility to generate tomographic retinal cross-sections to non-interferometric imaging systems such as en-face AO-ophthalmoscopes [4, 5]. We demonstrate that OIT can be applied to different imaging modalities using back-scattered and multiply-scattered light including systems without inherent optical sectioning. We ...

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    21. Study of vessel density in adult-onset foveomacular vitelliform dystrophy with Optical Coherence Tomography Angiography

      Study of vessel density in adult-onset foveomacular vitelliform dystrophy with Optical Coherence Tomography Angiography

      Background To evaluate retinal and choriocapillaris (CC) vessel density in macular region in patients affected by adult-onset foveomacular vitelliform dystrophy (AOFVD) using optical coherence tomography angiography (OCTA) Methods A total forty-four right eyes of 44 AOFVD patients (20 females, 24 males, mean age 69.17 ± 11.57 years) divided in 3 stages (vitelliform, pseudohypopyon and vitelliruptive) and 60 normal right eyes of 60 controls (20 females, 40 males, mean age 66.04 ± 6.40 years) were included in this prospective study. We evaluated the vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and CC in different macular ...

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    22. Short-Term Effects of Dark Chocolate on Retinal and Choriocapillaris Perfusion in Young, Healthy Subjects Using Optical Coherence Tomography Angiography

      Short-Term Effects of Dark Chocolate on Retinal and Choriocapillaris Perfusion in Young, Healthy Subjects Using Optical Coherence Tomography Angiography

      (1) Aim: Contrasting results have been published on the effect of dark chocolate on visual function. The aim of this study was to evaluate retinal and choriocapillaris perfusion, using optical coherence tomography angiography (OCT-A), and visual function in healthy subjects following dark chocolate ingestion. (2) Methods: This prospective randomized study was carried out on 18 healthy young subjects at the St. Andrea Hospital, Sapienza, University of Rome. Visual acuity assessment and a complete ophthalmologic examination were carried out at baseline. In session one, each subject was randomized to eat either a 100 g dark chocolate bar or a 100 g ...

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    23. Correlation of corneal pigmented arc with wide epithelial thickness map in orthokeratology-treated children using optical coherence tomography measurements

      Correlation of corneal pigmented arc with wide epithelial thickness map in orthokeratology-treated children using optical coherence tomography measurements

      Purpose To determine the intensity of corneal pigmented arc in orthokeratology (ortho-k)-treated children and its correlation with wide epithelial thickness map (ETM) obtained through anterior segment optical coherent tomography (AS-OCT). Methods This retrospective case series reviews medical records of children who received ortho-k treatment for myopia control. Intensity of ortho-k-associated pigmented arc after wearing ortho-k lens more than 12 months and its correlation with each sector/zone of wide ETM obtained by AS-OCT was explored. Pigmented arcs were further divided into apparent and unapparent groups, and the clinical differences between groups were determined. Results This study included 57 eyes ...

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