1. Articles in category: Ophthalmology

    73-96 of 14575 « 1 2 3 4 5 6 7 ... 606 607 608 »
    1. Swept Source Optical Coherence Tomography Compared to Ultrasound and Biomicroscopy for Diagnosis of Posterior Vitreous Detachment

      Swept Source Optical Coherence Tomography Compared to Ultrasound and Biomicroscopy for Diagnosis of Posterior Vitreous Detachment

      Background: Biomicroscopy, B-scan ultrasound imaging, and SD-OCT are all modalities used to characterize a posterior vitreous detachment (PVD). Our objective is to assess the precision of the diagnosis of PVD by SS-OCT. Methods: This prospective observational study examines ninety-five eyes of forty-nine patients with biomicroscopy, B-scan ultrasound, and SS-OCT for the presence or absence of a complete PVD. All SS-OCT images were reviewed by two retina specialists (RWSC, ZM). All three diagnostic methods were evaluated for agreement by Cohen’s kappa statistic. Results: The inter-rater reliability between retina specialists reading the SS-OCT images was 97.9% (κ = 0.957). Agreement on ...

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    2. Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements

      Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements

      Quantifying intraocular inflammation is crucial in managing uveitis patients. We assessed the minimum B-scan density for reliable automated vitreous intensity (VI) assessment, using a novel approach based on optical coherence tomography (OCT). OCT volume scans centered on the macula were retrospectively collected in patients with uveitis. Nine B-scans per volume scan at fixed locations were automatically analyzed. The following B-scan selections were compared against the average score of 9 B-scans per volume scan as a reference standard: 1/3/5/7 central scans (1c/3c/5c/7c), 3 widely distributed scans (3w). Image data of 49 patients (31 females) were ...

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    3. Optical Coherence Tomography findings in patients with Multiple Substance Use Disorder

      Optical Coherence Tomography findings in patients with Multiple Substance Use Disorder

      Objective Optical Coherence Tomography (OCT) is a relatively new diagnosis method displaying biological tissue layers by with high-resolution sections. In the present study, the purpose was to examine the OCT findings of patients with Multiple Substance Use Disorder (MSUD) by comparing these findings with healthy controls. Methods The study included 30 MSUD and 30 controls. Detailed biomicroscopic examinations were carried out for all participants, and intraocular pressure, followed by OCT. The central macular thickness (CMT), mean macular thickness (MMT), mean macular volume (MMV), and retinal nerve fibre layer thickness (RNFL) were measured by using OCT. Results It was determined that ...

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    4. SYSTEMS AND METHODS OF OPTICAL COHERENCE TOMOGRAPHY STEREOSCOPIC IMAGING FOR IMPROVED MICROSURGERY VISUALIZATION

      SYSTEMS AND METHODS OF OPTICAL COHERENCE TOMOGRAPHY STEREOSCOPIC IMAGING FOR IMPROVED MICROSURGERY VISUALIZATION

      Background. Smoking is one of the leading causes of death worldwide. smoking has played a role in the cause of death of approximately 6 million people per year (Muezzinler et al., 2015). While some diseases that cause morbidity and mortality from smoking include myocard infarct, cerebrovascular damage, lung cancer and chronic obstructive pulmonary disease. Smoking is also one of the factors that affects damage to visual disorders, such as cataracts, or macular degeneration (McNabula and Gill, 2009; Mojon et al., 2008). Smoking can result in changes in retinal and choroidal vascular and endothelial reactivity and high risk of affecting the ...

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    5. Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy

      Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy

      Purpose: To describe microvascular changes in the maculas of individuals with type 2 diabetes observed on optical coherence tomography angiography (OCTA) images. We compared the maculas of diabetic subjects without diabetic retinopathy with those of healthy subjects and correlated the findings with the clinical profiles of diabetic subjects. Methods: One eye each of 30 patients with diabetes and 30 healthy individuals were examined. The patients with diabetes underwent funduscopy, retinography, and fluorescein angiography to rule out retinopathy. All subjects underwent optical coherence tomography angiography of a macular area (6×6 mm 2 ), and the foveal and parafoveal vascular densities were ...

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    6. Can deep learning improve the automatic segmentation of deep foveal avascular zone in optical coherence tomography angiography

      Can deep learning improve the automatic segmentation of deep foveal avascular zone in optical coherence tomography angiography

      Optical coherence tomography angiography (OCTA) is extensively used for visualizing retinal vasculature, including the foveal avascular zone (FAZ). Assessment of the FAZ is critical in the diagnosis and management of various retinal diseases. Accurately segmenting the FAZ in the deep retinal layer (dFAZ) is very challenging due to unclear capillary terminals. In this study, a customized encoder-decoder deep learning network was used for dFAZ segmentation. Six-fold cross-validation was performed on a total of 80 subjects (63 healthy subjects and 17 diabetic retinopathy subjects). The proposed method obtained an average Dice of 0.88 and an average Hausdorff distance of 17 ...

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    7. Microscope-Integrated Optical coherence Tomography Assisted Pre-Descemetic Endothelial Keratoplasty

      Microscope-Integrated Optical coherence Tomography Assisted Pre-Descemetic Endothelial Keratoplasty

      Four patients of pseudophakic corneal edema were subjected to pre-Descemetic endothelial keratoplasty (PDEK) under the direct guidance of microscope-integrated optical coherence tomography (i-OCT). i-OCT facilitated successful type 1 big-bubble formation during donor preparation, debridement of hypertrophic epithelium, planning and placement of surgical wounds, descemetorrhexis with removal of remnant Descemet membrane tags, and identification of correct donor orientation and interface details. It was also possible to discern the stability of intraocular lens, flat iris configuration, adequate stromal hydration and wound apposition on i-OCT. Preoperative visual acuity was counting fingers (50%), 0.78 logMAR (25%) and 1.48 logMAR (25%), while postoperative ...

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      Mentions: Amar Agarwal
    8. Angle-closure assessment in anterior segment OCT images via deep learning

      Angle-closure assessment in anterior segment OCT images via deep learning

      Precise characterization and analysis of anterior chamber angle (ACA) are of great importance in facilitating clinical examination and diagnosis of angle-closure disease. Currently, the gold standard for diagnostic angle assessment is observation of ACA by gonioscopy. However, gonioscopy requires direct contact between the gonioscope and patients' eye, which is uncomfortable for patients and may deform the ACA, leading to false results. To this end, in this paper, we explore a potential way for grading ACAs into open-, appositional- and synechial angles by Anterior Segment Optical Coherence Tomography (AS-OCT), rather than the conventional gonioscopic examination. The proposed classification schema can be ...

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    9. Evaluation of axial length measurement using enhanced retina visualization mode of the swept-source optical coherence tomography biometer in dense cataract

      Evaluation of axial length measurement using enhanced retina visualization mode of the swept-source optical coherence tomography biometer in dense cataract

      Introduction: It has been reported that even using the swept-source optical coherence biometer, it is challenging to measure the axial length (AL) in cases with advanced cataracts. The enhanced retina visualization (ERV) mode, which is equipped with OCTB1 (ARGOS), shifts the peak of measurement sensitivity to the retina side so that the AL can be measured even if the light energy is attenuated. The aim of the present study was to evaluate the accuracy and efficacy of the ERV mode in measuring the AL of dense cataracts. Methods: This was a single-center retrospective observational case series conducted in Japan. We ...

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    10. Johns Hopkins University Receives NIH Grant for Artificial Intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Kerotoplasty (Auto-Dalk)

      Johns Hopkins University Receives NIH Grant for Artificial Intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Kerotoplasty (Auto-Dalk)

      Johns Hopkins University Receives a 2021 NIH Grant for $409,997 for Artificial Intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Kerotoplasty (Auto-Dalk). The principal investigator is Jin U. Kang. Below is a summary of the proposed work. Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-instruments, where the outcomes are often limited by the surgeon's skill levels and experiences. To overcome these human factors, we have assembled an interdisciplinary team including a clinician-scientist and eye surgeon, an optical device scientist and medical robotic engineers to translate existing and ...

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    11. Oregon Science and Health University Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Science and Health University Receives NIH Grant  for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Science and Health University Receives a 2021 NIH Grant for $440,684 for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the eye, including the cornea, conjunctiva, sclera, anterior chamber, iris, and crystalline lens. Anterior segment OCT is already widely used in ophthalmology. But a number of high-impact applications were held back ...

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    12. Segmentation in optical coherence tomography imaging

      Segmentation in optical coherence tomography imaging

      A method for improving segmentation in optical coherence tomography imaging. The method comprises obtaining an OCT image of imaged tissue, generating a first feature image for at least a portion of the OCT image, and generating a second feature image for at least the portion of the OCT image, based on either the OCT image or the first feature image, by integrating image data in a first direction across the OCT image or first feature image. A third feature image is generated as a mathematical function of the first and second feature images, and layer segmentation for the OCT image ...

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      Mentions: Alcon
    13. Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity

      Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity

      To describe the foveal avascular zone (FAZ) and vessel density (VD) in the superficial and deep capillary plexus in children with a history of prematurity on optical coherence tomography angiography (OCTA) and their correlation with gestational age (GA) and birth weight (BW). Methods We enrolled 81 preterm- and eight term-born children in this prospective observational study. The Optovue RTVue AVANTI (Optovue Inc., Fremont, CA) was used to procure the OCTA images. The 3 × 3 mm scan protocol centered on the fovea and the central 1 mm of the grid along with the FAZ of the superficial capillary plexus (SCP) and ...

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      Mentions: Optovue
    14. Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography

      Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography

      Importance: Determination of retinal thinning rates may help to identify patients who are at risk of progression of sickle cell retinopathy. Objective: To assess the rates of macular thinning in adults with and without sickle cell retinopathy using spectral-domain optical coherence tomography (OCT) and to identify ocular and systemic risk factors associated with retinal thinning. Design, setting, and participants: This longitudinal prospective case-control study enrolled adult participants from a university-based retina subspecialty clinic between February 11, 2009, and July 3, 2019. The study was designed in autumn 2008 and conducted from February 2, 2009, to July 3, 2020. Participants with ...

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    15. Macular thickness analysis and resolution of subretinal drusenoid deposits with optical coherence tomography in vitamin A deficiency-related retinopathy

      Macular thickness analysis and resolution of subretinal drusenoid deposits with optical coherence tomography in vitamin A deficiency-related retinopathy

      Purpose To report the resolution of subretinal drusenoid deposits (SDDs) and the changes in macular thickness at various segmentation levels in a patient who was treated for vitamin A deficiency-related retinopathy. Observations A 67-year-old man with cirrhosis secondary to hepatitis C was referred for unexplained vision decline and nyctalopia. He was diagnosed with vitamin A deficiency after he was found to have yellow-white drusen-like deposits in the posterior pole and midperiphery, which corresponded to SDDs on optical coherence tomography (OCT). Treatment with vitamin A supplementation was initiated, and, over the course of eight months, the symptoms improved, the SDDs resolved ...

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    16. Evaluation of Lamina Cribrosa by Using Enhanced Depth Imaging Optical Coherence Tomography in Ocular Sarcoidosis during Quiescent Phase

      Evaluation of Lamina Cribrosa by Using Enhanced Depth Imaging Optical Coherence Tomography in Ocular Sarcoidosis during Quiescent Phase

      Significance: Enhanced depth imaging optical coherence tomography is a useful method to allow for the evaluation of deep ocular structures, such as choroid and lamina cribrosa (LC), which are affected by ocular diseases. We hypothesized that choroidal and optic nerve inflammation in patients with ocular sarcoidosis (OS) might affect the LC structure. Purpose: This study aimed to evaluate changes in the LC and anterior LC depth (ALCD) in patients with OS. Methods: Forty-eight eyes of 26 patients with OS who received the treatment of panuveitis and were in the quiescent phase for at least 6 months were included in the ...

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    17. Comparison of Subjective and Objective Methods of Corneoscleral Limbus Identification from Anterior Segment Optical Coherence Tomography Images

      Comparison of Subjective and Objective Methods of Corneoscleral Limbus Identification from Anterior Segment Optical Coherence Tomography Images

      Significance: This study evaluates the reliability and validity of an automatic method of the external and internal limbal points identification from anterior segment optical coherence tomography (OCT) images in comparison with manual delineation. Purpose: The purpose of this work was to evaluate the repeatability and precision of a previously proposed automatic method of external and internal limbal points identification and to compare them with the manual delineation by experienced clinicians in terms of limbus diameter. Methods: Optical coherence tomography tomograms obtained for 12 healthy volunteers without a history of eye diseases were analyzed. Fifteen OCT tomograms were captured for each ...

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    18. Optical coherence tomography angiography in miliary tuberculosis

      Optical coherence tomography angiography in miliary tuberculosis

      A 14-year-old female was admitted with a history of high-grade fever. On admission, she underwent a comprehensive clinical, laboratory, and radiological evaluation. A contrast-enhanced computed tomography (CT) scan of the chest revealed multiple, tiny, nodular opacities in a ground-glass pattern bilaterally. Sputum studies were positive for Mycobacterium tuberculosis . Dilated fundus examination revealed multiple, yellow-white, deep choroidal lesions consistent with choroidal tubercles. She underwent optical coherence tomography angiography (OCTA) in both eyes, which revealed normal superficial and deep retinal plexuses but multiple areas of flow void in the choriocapillaris. The optical coherence tomography (OCT) sections showed hyperreflective areas in the choriocapillaris ...

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    19. Optical coherence tomography biomarkers as predictive factors for postoperative visual acuity in patients with epiretinal membrane treated with vitrectomy

      Optical coherence tomography biomarkers as predictive factors for postoperative visual acuity in patients with epiretinal membrane treated with vitrectomy

      Background: The purpose of this retrospective study was to evaluate potential predictive factors of postoperative visual outcome in patients with idiopathic epiretinal membrane (iERM), treated with pars plana vitrectomy (PPV). Methods: Participants in the study were 46 patients diagnosed with iERM, who underwent PPV. Best-corrected visual acuity measurement and spectral domain-optical coherence tomography (OCT) were performed at baseline (preoperatively), and at months 6 and 12 postoperatively. Demographic characteristics and OCT parameters were assessed as potential predictive factors for postoperative visual outcome. Results: Increasing age, retinal thickness, presence of disorganization of inner retinal layers, ellipsoid zone disruption, and presence of vitreomacular ...

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    20. Anterior segment optical coherence tomography and ultrasound biomicroscopy for measuring thickness of corneal and bulbar conjunctival tumours

      Anterior segment optical coherence tomography and ultrasound biomicroscopy for measuring thickness of corneal and bulbar conjunctival tumours

      Background/objective: Anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) are two non-invasive imaging techniques used for the measurement of tumour thickness in corneal and bulbar conjunctival tumours. Histopathology (HP), however, remains the gold standard for the measurement of tumour thickness. The aim of this study was to determine whether AS-OCT and UBM are as accurate as HP for measuring tumour thickness. Methods: Forty-two corneal and bulbar conjunctival tumours were imaged using AS-OCT and UBM. Images were assessed and tumour thickness was measured. Eleven patients subsequently underwent surgical excision. All specimens were measured during histopathological analysis. The correlation ...

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    21. A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      Cataract surgery with intraocular lens (IOL) implantation is generally a safe procedure with a very low complication rate.1 Where complications occur that are related to the IOL biomaterial, these can cause partial or complete lens opacification, and we categorize them according to the water-content of the IOL: “Glistenings,” microvacuole inclusions in the polymer are most commonly found in hydrophobic acrylic IOLs,2,3 while the pathology most associated with hydrophilic acrylic IOLs is calcification, an opacification resulting from Calcium compound depositions.

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    22. Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      PURPOSE : To compare the achieved vault using the conventional manufacturer's nomogram and the predicted vault using machine learning, in a large cohort of eyes undergoing posterior chamber phakic intraocular lens (EVO ICL, STAAR Surgical) implantation. DESIGN : Reliability and validity assessment and comparison. METHODS : Our study comprised a total of 1745 eyes of 1745 consecutive patients (mean age ± standard deviation, 26.2 ± 6.8 years) undergoing ICL implantation. At 1-month postoperatively, we quantitatively measured the actual vault, and compared it with the predicted vault using machine leaning of anterior segment optical coherence tomography (CASIA 2, Tomey) metrics. RESULTS : All machine ...

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    23. Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence

      Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence

      Machine learning has greatly facilitated the analysis of medical data, while the internal operations usually remain intransparent. To better comprehend these opaque procedures, a convolutional neural network for optical coherence tomography image segmentation was enhanced with a Traceable Relevance Explainability (T-REX) technique. The proposed application was based on three components: ground truth generation by multiple graders, calculation of Hamming distances among graders and the machine learning algorithm, as well as a smart data visualization (‘neural recording’). An overall average variability of 1.75% between the human graders and the algorithm was found, slightly minor to 2.02% among human graders ...

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    24. Early alterations in retinal microvasculature on swept-source optical coherence tomography angiography in acute central serous chorioretinopathy

      Early alterations in retinal microvasculature on swept-source optical coherence tomography angiography in acute central serous chorioretinopathy

      The purpose of the study was to evaluate the retinal blood flow in patients with acute central serous chorioretinopathy (CSC) over an observational period of 1 month using swept-source optical coherence tomography (SS-OCTA), focusing especially on changes in the area of subretinal fluid (A-SRF). We correlated these findings with conventional indocyanine green angiography (ICGA). ICGA and SS-OCTA images were collected and analyzed of 12 eyes of 12 patients. The A-SRF was annotated and a qualitative analysis of choriocapillaris, the vessel density (VD) and perfusion density (PD) of the retinal superficial capillary plexus (SCP) and the deep capillary plexus (DCP) was ...

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