1. Articles in category: Ophthalmology

    73-96 of 11376 « 1 2 3 4 5 6 7 ... 472 473 474 »
    1. Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma

      Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma

      Purpose To segment the inner macular layers (IML) and compare the discriminating abilities of the macular and peripapillary retinal nerve fiber layer (mRNFL and pRNFL, respectively) thicknesses in patients with early-stage normal tension glaucoma (NTG). Design Cross-sectional study Methods Forty-nine normal subjects and 69 preperimetric glaucoma (PPG) and 60 NTG patients were enrolled. Spectral-domain optical coherence tomography (SD-OCT) was used to obtain pRNFL and macular thickness parameters and segment the IML in all subjects. Area under the receiver operating characteristic (AUROC) curves were used to compare the diagnostic capabilities of different parameters. Results The pRNFL, total macular layer (TML), mRNFL ...

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    2. Image Artifacts In Optical Coherence Tomography Angiography Among Patients With Multiple Sclerosis

      Image Artifacts In Optical Coherence Tomography Angiography Among Patients With Multiple Sclerosis

      Purpose : To evaluate artifacts in OCT-A images of multiple sclerosis (MS) patients and healthy controls. Materials and Methods : This was a prospective cross-sectional study conducted at the Department of Neurology and the Wilmer Eye Institute at Johns Hopkins Hospital. Subjects included patients with an established diagnosis of MS and healthy volunteers. OCT-A was performed using Spectralis® OCT-A prototype, OCT2 (Heidelberg, Germany). The type and frequency of artifacts, the clinical factors associated with them, and their impact on vessel density measurements were assessed. Results : Overall, 385 images from 102 participants were analyzed. The majority of images (97.1%) had some degree ...

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    3. Digital Imaging in Vitreoretinal Surgery Advances could improve surgical outcomes and change how vitrectomy is taught

      Digital Imaging in Vitreoretinal Surgery Advances could improve surgical outcomes and change how vitrectomy is taught

      S urgery is an ever-evolving field, driven toward achieving better outcomes with fewer complications. Therefore, it is a natural frontier for the development and application of novel technologies, designed to improve results, make procedures easier, and make the impossible a reality. Vitreoretinal surgery is a highly advanced and specialized subfield of surgery, which relies heavily on technology. For instance, although primitive forms of ocular surgery have existed for centuries, vitreoretinal surgery has only been possible for several decades. Taking retinal detachment as an example, it was an irreversible blinding condition until the development of scleral buckling by Schepens in the ...

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    4. Diabetic retinal neuropathy revisited. A perspective after optical coherence tomography angiography

      Diabetic retinal neuropathy revisited. A perspective after optical coherence tomography angiography

      Diabetic retinal neuropathy is a disorder that can appear before clinical signs of diabetic retinopathy; the evidence of neuronal damage has been reported in histologic and experimental studies in subjects with diabetic retinopathy. Signs of early dysfunction can be identified using functional tests such as retinal sensitivity, contrast sensitivity, color vision and electroretinogram, all of which show changes in diabetic subjects without retinopathy compared with non-diabetic subjects. Optical coherence tomography has identified a thinning of the ganglion cell layer in diabetic subjects without retinopathy, which has been considered a surrogate of early neuronal damage and has been proposed to develop ...

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    5. Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration

      Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration

      Background Epilepsy is a chronic neurological disease characterized with recurrent seizures. Progressive neuronal degeneration is a common consequence of long-term and/or recurrent seizure activity in epilepsy. Optical coherence tomography (OCT) is a new medical imaging technique that displays biological tissue layers as high-resolution tomographic sections. The aim of our study was to evaluate OCT findings in patients with epilepsy and to compare OCT findings in terms of disease duration , presence of status, seizure frequency, and drug use. Methods Forty-three patients who had epilepsy according to the Commission on Classification and Terminology of the International League Against Epilepsy (ILAE) in ...

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    6. Correlation of SWAP (short wavelength automated perimetry) with OCT (optical coherence tomography in pre perimetric glaucoma

      Correlation of SWAP (short wavelength automated perimetry) with OCT (optical coherence tomography in pre perimetric glaucoma

      Purpose To find out correlation of swap and OCT in preperimetric glaucoma patient coming to Dhiraj general hospital. Materials and Methods A complete ophthalmological examination will be done including uncorrected and best corrected visual acuity, slit lamp examination, central corneal thickness measurement by pachymetry, applanation tonometry, gonioscopy and dilated fundus examination and Humphrey perimetry followed by SWAP and FDT. Result In the present study a total of 50 patients were screened. Out of this 22 patients had a CDR of 0.5 with healthy neuroretinal rim (HNRR) in both the eyes. One patient had 0.5 CDR with inferior thinning ...

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    7. Inner macular layer thickness by spectral domain optical coherence tomography in children and adults: a hospital-based study

      Inner macular layer thickness by spectral domain optical coherence tomography in children and adults: a hospital-based study

      Purpose To establish the normative ranges of macular ganglion cell layer (mGCL) and macular inner plexiform layer (mIPL) thickness using Spectralis spectral domain optical coherence tomography (SD-OCT) (Heidelberg Engineering, Inc., Heidelberg, Germany) in both Korean children and adults, and to determine factors associated with mGCL and mIPL thickness. Methods We conducted a retrospective, observational study of 573 healthy subjects (5–70 years old) who underwent comprehensive ophthalmic examinations in a single institution. Each inner retinal layer thickness was measured using SD-OCT and automatic segmentation software. Cross-sectional analysis was used to evaluate the effect of gender, age and ocular parameters on ...

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    8. Colloidal silver toxicity with absence of choroidal signal on optical coherence tomography

      Colloidal silver toxicity with absence of choroidal signal on optical coherence tomography

      Silver, aside from its physical properties making it popular for electric applications and in jewellery, has a history of being used to treat various medical conditions. 1 It has been used to treat mental illness, epilepsy, gastrointestinal disorders, and infectious diseases and in surgical prostheses. 1 A review performed by Drake and Hazelwood in 2005 suggested that metallic silver posed minimal risk to health—the most common side effects being argyria (greyish discoloration of the skin) and argyrosis (greyish discoloration of the sclera). 1 Exposure to soluble silver may result in toxic effects such as kidney, liver, respiratory, gastrointestinal, hematopoietic ...

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    9. OPTICAL COHERENCE TOMOGRAPHY PREDICTORS OF SHORT-TERM VISUAL ACUITY IN EYES WITH MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL CONBERCEPT

      OPTICAL COHERENCE TOMOGRAPHY PREDICTORS OF SHORT-TERM VISUAL ACUITY IN EYES WITH MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL CONBERCEPT

      Purpose: To identify the spectral domain optical coherence tomography predictors of visual prognosis in retinal vein occlusion macular edema after intravitreal conbercept injection. Methods: Retrospective cohort study of 63 treatment-naive retinal vein occlusion macular edema eyes received pro re nata intravitreal conbercept with at least 3 months of follow-up. The best-corrected visual acuity (BCVA) and optical coherence tomography scans were recorded at baseline, 1 month, and 3 months after starting therapy. On spectral domain optical coherence tomography , the following lesions in the 1-mm-wide retinal area centered on the fovea: disorganization of the retinal inner layer extent, cysts, hyperreflective foci, microaneurysms ...

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    10. Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema

      Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema

      Purpose : The purpose of this study is to evaluate differences in optical coherence tomography angiography (OCT-A) findings between patients with papilledema and pseudopapilledema. Methods : In this prospective, comparative study, 41 eyes of 21 subjects with papilledema, 27 eyes of 15 subjects with pseudopapilledema, and 44 eyes of 44 healthy normal subjects were included and were imaged using OCT-A. In addition to peripapillary total vasculature maps obtained with commercial vessel density mapping, major vessel removal using customized image analysis software was also used to measure whole image capillary density and peripapillary capillary density (PCD). Peripapiilary retinal nerve fiber layer (RNFL) and ...

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    11. Region-segmentation strategy for Bruch’s membrane opening detection in spectral domain optical coherence tomography images

      Region-segmentation strategy for Bruch’s membrane opening detection in spectral domain optical coherence tomography images

      Bruch’s membrane opening (BMO) is an important biomarker in the progression of glaucoma. Bruch’s membrane opening minimum rim width (BMO-MRW), cup-to-disc ratio in spectral domain optical coherence tomography (SD-OCT) and lamina cribrosa depth based on BMO are important measurable parameters for glaucoma diagnosis. The accuracy of measuring these parameters is significantly affected by BMO detection. In this paper, we propose a method for automatically detecting BMO in SD-OCT volumes accurately to reduce the impact of the border tissue and vessel shadows. The method includes three stages: a coarse detection stage composed by retinal pigment epithelium layer segmentation, optic ...

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    12. Sensitivity of indocyanine green angiography compared to fluorescein angiography and enhanced depth imaging optical coherence tomography during tapering and fine-tuning of therapy in primary stromal choroiditis: A case series

      Sensitivity of indocyanine green angiography compared to fluorescein angiography and enhanced depth imaging optical coherence tomography during tapering and fine-tuning of therapy in primary stromal choroiditis: A case series

      Purpose To investigate indocyanine green angiography (ICGA), fluorescein angiography (FA), and enhanced depth imaging optical coherence tomography measured choroidal thickness (EDI-OCT-CT) in the follow-up of inflammatory activity in stromal choroiditis [Vogt-Koyanagi-Harada disease (VKH) and birdshot retinochoroiditis (BRC)] under treatment in order to monitor tapering of therapy or readjustment of therapy in case of subclinical disease recurrence . Methods Patients with initial onset disease and/or treatment-naive stromal choroiditis (VKH & BRC) at entry, quiet under therapy, and having had a follow-up of at least four years monitored with dual FA and ICGA and EDI-OCT-CT measurements were analyzed retrospectively. ICGA and FA scores ...

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    13. Spontaneous anterior dislocation of lens in a case of ectopia lentis et pupillae: a rare entity treated by a novel technique of microscope integrated optical coherence tomography (MIOCT) guided intralenticular lens aspiration

      Spontaneous anterior dislocation of lens in a case of ectopia lentis et pupillae: a rare entity treated by a novel technique of microscope integrated optical coherence tomography (MIOCT) guided intralenticular lens aspiration

      A 7-year-old girl presented with watering and redness in the left eye for 2 months. Her parents reported poor vision in both eyes for 4 years. Visual acuity was finger counting at 1 m and finger counting close to face in the right and left eyes, respectively. Slit lamp examination of the right eye revealed corectopia, aphakia in the pupillary area, temporally subluxated clear crystalline lens, persistent pupillary membrane, irido-hyaloidal adhesion and poorly dilating pupil. Left eye revealed central corneal oedema with descemet scarring, anteriorly dislocated clear crystalline lens with lenticulo-corneal touch. Ultrasound examination of the left eye was normal ...

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    14. Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia

      Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia

      AIM : To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness obtained by spectral-domain optical coherence tomography (SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma (PPG) from highly myopic healthy eyes. METHODS : A total of 254 eyes, including 76 normal controls (NC), 116 eyes with high myopia (HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by the areas under the receiver operating characteristic (AUROC) curve in two distinguishing groups: PPG eyes with non-glaucomatous eyes including NC and HM (Group 1), and PPG eyes with HM eyes ...

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    15. Sex-Related Variations of Retinal and Choroidal Thickness and Foveal Avascular Zone in Healthy and Diabetic Children Assessed by Optical Coherence Tomography Imaging

      Sex-Related Variations of Retinal and Choroidal Thickness and Foveal Avascular Zone in Healthy and Diabetic Children Assessed by Optical Coherence Tomography Imaging

      Purpose of the Study: The aim of this study was to investigate the presence of gender differences in the chorioretinal microvasculature of children with and without vascular pathology. Methods: Healthy and type 1 diabetic children without diabetic retinopathy underwent optical coherence tomography angiography (OCTA) and structural OCT. We measured the foveal avascular zone (FAZ) area in the superficial capillary plexus (SCP) and deep CP (DCP), central retina, and choroid thickness. Results: OCTA examination was conducted in 112 diabetic and 30 healthy children, and structural OCT in 121 diabetic children and 32 controls. DCP FAZ area in boys was significantly smaller ...

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    16. Retinal Microvascular Change in Hypertension as measured by Optical Coherence Tomography Angiography

      Retinal Microvascular Change in Hypertension as measured by Optical Coherence Tomography Angiography

      Many studies have reported the effect of hypertension on microcirculation of the retina. Advance of optical coherence tomography angiography (OCTA) allows us more detailed observations of microcirculation of the retina. Therefore, we compared OCTA parameters between chronic hypertension (disease duration of at least 10 yrs; Group A, 45 eyes), relieved hypertensive retinopathy (grade IV HTNR < 1 yr prior; Group B, 40 eyes), and normal controls [Group C (50 eyes) ≥ 50 yrs old and Group D (50 eyes) < 50 yrs old]. A 3 × 3 mm macular scan was performed in each group by OCTA. In vessel density of 3 mm full ...

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    17. Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography

      Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography

      Aims To evaluate the microvascular and neural differences of the optic nerve head (ONH) between type 2 diabetes mellitus (T2DM) subjects and controls. Methods This was a cross-sectional observational study. One hundred and eight eyes of 108 T2DM subjects with or without diabetic retinopathy (DR) (54 preclinical DR and 54 mild-to-moderate DR) were included. Fifty-two eyes of 52 healthy subjects were included as controls. The 4.5-mm Angio Disc scan mode and the ganglion cell complex scan mode were performed with all participants using AngioVue software 2.0 of the optical coherence tomography angiography (OCTA) device. Results Regarding ONH radial ...

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    18. Optical Coherence Tomography Angiography Findings in Chronic Central Serous Chorioretinopathy After Photodynamic Therapy

      Optical Coherence Tomography Angiography Findings in Chronic Central Serous Chorioretinopathy After Photodynamic Therapy

      BACKGROUND AND OBJECTIVES: To report the acute and long-term choroidal findings in patients with chronic central serous chorioretinopathy (CCSC) undergoing half-fluence photodynamic therapy (PDT). PATIENTS AND METHODS: This is a prospective, consecutive, interventional, noncomparative case series at a tertiary referral vitreoretinal practice. Twenty-one eyes from 21 patients are included. RESULTS: Among 21 eyes, all had improved vision following PDT during a mean of 5.2 months ± 4.8 months of follow-up. The incidence of choroidal neovascular membranes was 19.0% (four in 21), with only one of these eyes (4.8%) requiring intravitreal anti-vascular endothelial growth factor injections. Changes in ...

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    19. Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

      Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

      The aim of this narrative mini review is to analyze optical coherence tomography angiography (OCTA) parameters from reports that involved both superficial and deep vascular layers in patients with diabetes and to assess their relevance for the pathogenesis of diabetic retinopathy (DR). Papers published from January 2015 to August 2018 describing the use of OCTA in diabetes were identified and reviewed through a Medline/PubMed search. OCTA studies suggest that parameters are altered in patients with diabetes in all retinal vascular layers. From all included studies that evaluated both the superficial and the deep vascular layer, a number of studies ...

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    20. SWEPT-SOURCE AND SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS DYE ANGIOGRAPHY IN THE MEASUREMENT OF TYPE 1 NEOVASCULARIZATION

      SWEPT-SOURCE AND SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS DYE ANGIOGRAPHY IN THE MEASUREMENT OF TYPE 1 NEOVASCULARIZATION

      Purpose: To compare the area of Type 1 neovascularization in patients with age-related macular degeneration calculated on spectral domain optical coherence tomography angiography (SD-OCTA), swept-source OCTA, and indocyanine green angiography (ICGA). Methods: Cross-sectional study enrolling patients with neovascular age-related macular degeneration with Type 1 neovascularization . During the same visit, ICGA (Spectralis HRA, Heidelberg, Germany), 3 × 3-mm or 6 × 6-mm SD-OCTA (CIRRUS AngioPlex model 5000; Carl Zeiss Meditec, Inc, Dublin, OH), and 3 × 3-mm or 6 × 6-mm swept-source OCTA (Plex Elite 9000; Carl Zeiss Meditec, Inc) were performed. Neovascularization areas were compared among the three instruments. The degree of consistency between ...

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    21. Impact of automated OCT in a highvolume eye urgent care setting

      Impact of automated OCT in a highvolume eye urgent care setting

      Background/Aims Optical coherence tomography (OCT) has become standard of care in the diagnosis and management of a myriad of retinal and optic nerve pathology. Access to diagnostic equipment and skilled imaging personnel in the after-hours setting is often limited. We examined the utility and diagnostic indications for automated OCT in a high-volume after-hours clinic within an eye institute. Methods OCT images obtained over a period of 15 months were reviewed in the context of electronic patient records. Residents and fellows were surveyed regarding their experience with the OCT and its value in emergency patient management. Results 202 patients and ...

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      Mentions: Richard B. Rosen
    22. Tear film analysis and evaluation of optical quality: A review of the literature

      Tear film analysis and evaluation of optical quality: A review of the literature

      Dry eye is a complex multifactorial disease of the ocular surface and tears. It is associated with ocular surface symptoms and is one of the most common causes for ophthalmologic consultation. Despite their frequent use in clinical practice, the usual tests to evaluate dry eye and ocular surface disease–history of symptoms, tear break-up time (TBUT), Meibomian gland evaluation, corneal fluorescein staining, Schirmer test–have shown low reproducibility and reliability. In addition, subjective symptoms are often weakly or poorly correlated with objective signs. Since the tear film is the first system through which light must pass, the optical quality of ...

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    23. Increased Subfoveal Choroidal Thickness and Retinal Structure Changes on Optical Coherence Tomography in Pediatric Alport Syndrome Patients

      Increased Subfoveal Choroidal Thickness and Retinal Structure Changes on Optical Coherence Tomography in Pediatric Alport Syndrome Patients

      Objective . To evaluate optical coherence tomography (OCT) findings of pediatric Alport syndrome (AS) patients with no retinal pathology on fundus examination. Materials and Methods . Twenty-one patients being followed up with the diagnosis of AS (Group 1) and 24 age- and sex-matched healthy volunteers (Group 2) were prospectively evaluated. All participants underwent standard ophthalmologic examination, retinal nerve fibre layer (RNFL) analysis, and horizontal and vertical scan macula enhanced depth imaging OCT (EDI-OCT). Statistical analysis of the data obtained in this study was performed with SPSS 15.0. Results . Macula thickness was significantly decreased in the temporal quadrant in Group 1 compared ...

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    24. NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF A CASE OF SYMPATHETIC OPHTHALMIA AFTER 23-GAUGE VITRECTOMY

      NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF A CASE OF SYMPATHETIC OPHTHALMIA AFTER 23-GAUGE VITRECTOMY

      Purpose: Sympathetic ophthalmia (SO) is a rare panuveitis after trauma to one eye. We present a case of SO after 23-gauge transconjunctival vitrectomy , including optical coherence tomography evidence of response to treatment. To our knowledge, this is the first SO case report to include spectral domain optical coherence tomography images of Dalen-Fuchs nodules. Methods: Observational case report of a case of SO after two pars plana vitrectomies in the fellow eye. Results: A 67-year-old woman who had an operation for her pseudophakic left eye for a macula-off retinal detachment . She had two surgeries and later on had a total retinal ...

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