1. Articles in category: Ophthalmology

    73-96 of 12085 « 1 2 3 4 5 6 7 ... 502 503 504 »
    1. Displacement of the Foveal Retinal Layers After Macular Hole Surgery Assessed Using En Face Optical Coherence Tomography Images

      Displacement of the Foveal Retinal Layers After Macular Hole Surgery Assessed Using En Face Optical Coherence Tomography Images

      BACKGROUND AND OBJECTIVE: To investigate the displacement of foveal retinal layers in surgically closed macular holes (MHs) after removal of the internal limiting membrane (ILM). PATIENTS AND METHODS: Medical records of 26 consecutive patients who underwent vitrectomy and removal of the ILM for idiopathic MH were retrospectively reviewed. En face optical coherence tomography images were exported at the level of the choroid, ellipsoid zone (EZ), and inner plexiform layer (IPL) at baseline and at 1, 3, and 6 months. The foveal center of the EZ and IPL was marked in the choroid en face image. The choroidal images were overlapped ...

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    2. Diagnostic accuracy of optical coherence tomography angiography for choroidal neovascularization: a systematic review and meta-analysis

      Diagnostic accuracy of optical coherence tomography angiography for choroidal neovascularization: a systematic review and meta-analysis

      Background Optical coherence tomography angiography (OCTA), an innovative image technique, renders visualization of ocular neovascularization through non-invasive means, which has been applied in recent years. Therefore, the present study was designed to assess the diagnostic value of OCTA in detecting the choroidal neovascularization (CNV). Methods In brief, PubMed, Web of Science and Cochrane Library databases were systematically searched from January 2014 to June 2019. Afterwards, a meta-analysis was performed to determine the pooled diagnostic accuracy in a random-effects model using STATA 15.1 and Meta-Disc 1.4 software. Quality Assessment of diagnostic Accuracy Version 2 was used to evaluate the ...

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      Mentions: Rui Wang
    3. Exploring the relationship between collaterals and vessel density in retinal vein occlusions using optical coherence tomography angiography

      Exploring the relationship between collaterals and vessel density in retinal vein occlusions using optical coherence tomography angiography

      Purpose To characterize the types of collaterals in eyes with retinal vein occlusion (RVO) and further investigate their correlations with vessel densities of the superficial (SCP) and the deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). Methods This cross-sectional study included 25 eyes of 23 patients with RVO. 3 x 3 mm 2 OCTA macular scans were used to quantify the parafoveal vessel density (VD) of the SCP and DCP, and to classify the collaterals into one of four types (true superficial, true deep, superficial diving, and foveal collateral). Generalized estimating equation (GEE) regression analysis was performed to ...

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    4. Assessment of Choroidal Thickness Inside and Outside of Vascular Arcade in Diabetic Retinopathy Eyes Using Spectral-Domain Optical Coherence Tomography

      Assessment of Choroidal Thickness Inside and Outside of Vascular Arcade in Diabetic Retinopathy Eyes Using Spectral-Domain Optical Coherence Tomography

      This study aimed to characterise the distribution of choroidal thickness (CT) in diabetic retinopathy eyes, inside and outside of the vascular arcade, as well as at the fovea, using spectral-domain optical coherence tomography (OCT). Forty-nine healthy eyes, 80 diabetic retinopathy (DR) eyes (59 non-proliferative diabetic retinopathy (NPDR) eyes and 21 proliferative diabetic retinopathy (PDR) eyes) were examined with OCT to obtain nine horizontal lines (far superotemporal, near superotemporal, central, near inferotemporal, far inferotemporal, far superonasal, near superonasal, near inferonasal, far inferonasal) inside and outside of the vascular arcade. Nine points were chosen in 0.5-mm intervals to calculate CT, which ...

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    5. Optical Coherence Tomography Angiography and Macular Vessel Density Analysis of Cystoid Macular Edema in Gyrate Atrophy

      Optical Coherence Tomography Angiography and Macular Vessel Density Analysis of Cystoid Macular Edema in Gyrate Atrophy

      BACKGROUND AND OBJECTIVE: To understand the microvascular abnormalities in cystoid macular edema (CME) in gyrate atrophy. PATIENTS AND METHODS: Spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA) were used in four consecutive female patients (eight eyes) with clinically and biochemistry-confirmed cases of gyrate atrophy and associated CME. Foveal avascular zone (FAZ) area and macular vessel density percentage were calculated and compared with normal subjects. RESULTS: The average age was 20 years (range: 13 years to 32 years). The mean refractive error was −6.5 diopters (D) (range: −1.0 D to −11.0 D). The average central macular thickness ...

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    6. Enhanced depth imaging in swept-source optical coherence tomography: Improving visibility of choroid and sclera, a masked study

      Enhanced depth imaging in swept-source optical coherence tomography: Improving visibility of choroid and sclera, a masked study

      Purpose To compare enhanced depth imaging in swept-source optical coherence tomography and non–enhanced depth imaging optical coherence tomography in their ability to capture choroidal and scleral details. Methods Averaged foveal B-Scans were obtained from 40 eyes of 20 healthy volunteers by swept-source optical coherence tomography with and without enhanced depth imaging. Visibility and contrast of vascular details within the choroid, choroidoscleral junction, and sclera were evaluated by masked readers using an ordinal scoring scale. Outcomes were analyzed using the Wilcoxon signed rank-sum test. Results Visibility of the choroidal vascular details ( Z  = 5.94, p  < .001), the choroidoscleral junction ( Z ...

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    7. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study

      Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study

      Background Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only in an attack-dependent manner or also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes in eyes without new optic neuritis (ON) in MOG-IgG-seropositive patients. Methods We included 38 eyes of 24 patients without ON during follow-up (F/U) [median years (IQR)] 1.9 (1.0–2.2) and 56 eyes of 28 age- and sex-matched healthy controls (HC). The patient group’s eyes included 18 eyes without (Eye ON- ) and 20 ...

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      Mentions: Friedemann Paul
    8. System and method for detecting retina disease

      System and method for detecting retina disease

      A system and method for diagnosing retina disease is disclosed. The method comprises capturing a plurality of images of the vascular network within the retina, such as through the use of optical coherence tomography (OCT). This plurality of images are then processed to determine the location and diameter of each vessel in the three-dimensional vascular network in the retina. The vascular network is then divided into a plurality of equal unit volumes. The vessel density, vascular volume density and other metrics can then be determined for each unit volume. This information can then be used to identify retina disease. The ...

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    9. Fundus analysis apparatus and fundus observation apparatus

      Fundus analysis apparatus and fundus observation apparatus

      A fundus analysis apparatus includes a storage, an area setting unit, and a morphological information generating unit. The storage is configured to store OCT information acquired by applying optical coherence tomography to the fundus of an eye. The area setting unit is configured to set a front area corresponding to a front surface of the lamina cribrosa and a rear area corresponding to a rear surface of the lamina cribrosa in the OCT information. The morphological information generating unit is configured to generate morphological information indicating the morphology of the lamina cribrosa based on at least the front area and ...

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    10. Methods of performing surgery using optical coherence tomography (OCT)

      Methods of performing surgery using optical coherence tomography (OCT)

      Methods are provided including obtaining at least one image of a surgical region of a subject oriented for the surgical procedure using an OCT imaging system. An initial structural view of the surgical region to be used during the surgical procedure is constructed based on the obtained at least one OCT image. Parameters are computed as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image. The surgical procedure is periodically assessed and clinical outcomes are monitored using changes to the OCT-derived initial structural view of the surgical region or changes to ...

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    11. Ophthalmologic apparatus, tomographic image generation method, and program that determine an imaging region for capturing a plurality of tomographic images for generating an averaged tomographic image

      Ophthalmologic apparatus, tomographic image generation method, and program that determine an imaging region for capturing a plurality of tomographic images for generating an averaged tomographic image

      An ophthalmologic apparatus includes an error obtaining unit configured to obtain a value corresponding to a difference between a first imaging position which tracks a predetermined position of an eye portion under control of a tracking unit and the predetermined position, a determination unit configured to determine a position which is shifted from the first imaging position which tracks the predetermined position as a second imaging position in accordance with the value corresponding to the difference. The ophthalmologic apparatus averages tomographic images of the first and second imaging positions.

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    12. Automated OCT shows promise in urgent care setting

      Automated OCT shows promise in urgent care setting

      Expanded urgent care access to automated OCT shows promise in increasing accuracy and timeliness of diagnosis as well as providing immediate documentation of pathology to further substantiate medical decision making, according to a study published in BM J Open Ophthalmology. Access to skilled imaging personnel and diagnostic equipment is virtually nonexistent after normal working hours in most clinics, according to study authors. OCT has the ability to reveal more subtle macular changes, including those in the nerve fiber layer or outer retina, that would be imperceptible on clinical examination. “Other ophthalmic imaging modalities such as ocular ultrasound and nonmydriatic fundus ...

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      Mentions: Richard B. Rosen
    13. Assessment of optic edge and the posterior capsule junction on optical coherence tomography

      Assessment of optic edge and the posterior capsule junction on optical coherence tomography

      After cataract surgery, a frequent challenge faced by the anterior segment surgeon is posterior capsule opacification (PCO). Therefore, it is necessary to tackle this intraoperatively by thoroughly removing the lens capsule epithelial cells. 1 A square-edged intraocular lens (IOL) optic has also been shown to reduce the occurrence of PCO. 1 Determining the actual changes along the square edges of the IOL and the capsule junction is important in understanding why PCO develops.

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    14. The role of Müller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission

      The role of Müller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission

      Background To explore the role of foveal and parafoveal Müller cells in the morphology and pathophysiology of tractional macular disorders with a mathematical model of mechanical force transmission. Methods In this retrospective observational study, spectral-domain optical coherence tomography images of tractional lamellar macular holes and patients with myopic foveoschisis were reviewed and analysed with a mathematical model of force transmission. Parafoveal z-shaped Müller cells were modelled as a structure composed of three rigid rods, named R1, R2 and R3. The angle formed between the rods was referred to as θ . R1, R2 and R3 lengths as well as the ...

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    15. Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study

      Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study

      Purpose To evaluate the effect of a topical steroid instillation on recently developed incomplete nasolacrimal duct obstruction (NLDO) evaluated by using anterior segment optical coherence tomography (ASOCT). Methods Forty-nine eyes of 31 patients with incomplete NLDO who developed epiphora within 3 months were recruited and treated with a topical steroid for 3 months. Tear meniscus height (TMH) and area (TMA) were measured by ASOCT. The treatment was considered to be effective when there was improvement of subjective epiphora, normal tear meniscus on slit lamp examination, a fluorescein dye disappearance test with grade 0 or 1, and TMH < 250 μm on ...

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    16. High-resolution multimodal photoacoustic microscopy and optical coherence tomography image-guided laser induced branch retinal vein occlusion in living rabbits

      High-resolution multimodal photoacoustic microscopy and optical coherence tomography image-guided laser induced branch retinal vein occlusion in living rabbits

      Joint high-resolution multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) was developed to improve the efficiency for visualizing newly developed retinal neovascularization (RNV) and to monitor the dynamic changes of retinal vein occlusion (RVO) in living rabbits. The RNV and RVO models were created in New Zealand rabbits by Rose Bengal laser-induced RVO. Dual modalities imaging equipment, including color fundus photography, fluorescein angiography (FA), OCT, and PAM, was used to image and assess the changes of retinal vasculature. In vivo experimental results exhibited that not only the treatment boundaries and the position of the occluded vasculature but also the ...

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    17. Cornea Findings of Spectral Domain Anterior Segment Optical Coherence Tomography in Uveitic Eyes of Various Etiologies

      Cornea Findings of Spectral Domain Anterior Segment Optical Coherence Tomography in Uveitic Eyes of Various Etiologies

      Purpose: To evaluate the morphologic appearance of keratic precipitates (KPs) with spectral domain anterior segment optical coherence tomography (AS-OCT) for the diagnosis of uveitic eyes of various etiologies. Methods: In all, 153 eyes of 153 patients with different types of uveitis were examined to investigate the morphologic appearance of KPs. The study included 63 eyes with herpetic iridocyclitis/endotheliitis, 58 eyes with ocular sarcoidosis, 5 eyes with Fuchs heterochromic iridocyclitis, and 27 eyes with masquerade syndrome with primary intraocular lymphoma (PIOL). AS-OCT was used to analyze the different KP types among various uveitic groups. Results: KPs were observed in 30 ...

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      Mentions: Osaka University
    18. Peripheral hypertrophic subepithelial corneal degeneration: clinical aspects related to in vivo confocal microscopy and optical coherence tomography

      Peripheral hypertrophic subepithelial corneal degeneration: clinical aspects related to in vivo confocal microscopy and optical coherence tomography

      Purpose: To report the findings of anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) in two patients with peripheral hypertrophic subepithelial corneal degeneration (PHSD). Methods: Case series by retrospective chart review and imaging analysis of AS-OCT and IVCM. Results: Slit lamp examination of the two patients revealed a bilateral subepithelial-elevated fibrous tissue of the superior-nasal quadrant, as well as inferior-nasal in one of the patients. Best corrected visual acuity ranged from 20/25 to 20/15. AS-OCT showed continuous, homogenous, well-demarked hyperreflective subepithelial band associated with hyperreflectivity in the anterior stroma. IVCM demonstrated normal epithelial cell ...

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    19. Non-Invasive Longitudinal Imaging of the Developing Eye

      Non-Invasive Longitudinal Imaging of the Developing Eye

      n article published in Experimental Biology and Medicine (Volume 244, Issue 10, July, 2019) (https://journals.sagepub.com/doi/pdf/10.1177/1535370219850787 ) reports that noninvasive imaging techniques can be used to study eye development. The study, led by Dr. Xincheng Yao , Richard and Loan Hill Professor of Bioengineering and Ophthalmology at the University of Illinois at Chicago in Chicago Illinois (USA), demonstrates that quantitative optical coherence tomography and angiography can be used to monitor the vascular system during eye development in mouse models. The hyaloid vascular system (HVS) is a transient circulatory system that nourishes the eyes in the ...

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      Mentions: Xincheng Yao
    20. Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye

      Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye

      Hyaloid vascular system (HVS) is a transient capillary network nourishing developing eye. Better study of the HVS regression correlated with eye development is essential for in-depth understanding of the nature of vision system. In this study, we demonstrate the feasibility of longitudinal optical coherence tomography (OCT) and OCT angiography (OCTA) monitoring of the HVS in C57BL/6J mice. OCT enables morphological monitoring of the HVS regression, and OCTA allows physiological assessment of the HVS involution correlated with eye development. Functional OCTA reveals early physiological dysfunction before morphological regression of the hyaloid vasculature in developing mouse eye. We anticipate that noninvasive ...

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      Mentions: Xincheng Yao
    21. New Proposal For The Pathophysiology Of Type 3 Neovascularization As Based On Multimodal Imaging Findings

      New Proposal For The Pathophysiology Of Type 3 Neovascularization As Based On Multimodal Imaging Findings

      Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease. Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography , optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Results: There were 10 eyes of 9 patients who had a mean age of 87 (range 79–93) years and 7 were women. The patients were seen to have distributed areas of cystoid macular edema, not necessarily contiguous with areas of fluorescein or optical coherence tomography angiographic ...

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    22. Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      Purpose: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). Methods: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 50–99 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis (20 × 20° scan area) instruments, fundus autofluorescence, infrared imaging, and color fundus photography. Spectral domain optical coherence tomography characteristics were analyzed in subjects with AMD (with and without subretinal ...

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    23. Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography

      Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography

      Purpose To determine whether the glaucoma diagnostic accuracy of age and Bruch’s membrane opening area (BMOA) adjusted normative classifications of minimum rim width (MRW) and retinal nerve fibre layer thickness (RNFLT) is dependent on BMOA, in a European descent population. Design Retrospective, cross-sectional study. Methods We included 182 glaucoma patients and 166 healthy controls for the primary study, and 105 glaucoma patients in a second sample used for a replication study. Optical coherence tomography (Spectralis) measurements of BMOA, global MRW and RNFLT and normative classifications from the device software were exported for analysis. Sensitivity and specificity were calculated for ...

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    24. Optical coherence tomography angiography of superficial retinal vessel density and foveal avascular zone in myopic children

      Optical coherence tomography angiography of superficial retinal vessel density and foveal avascular zone in myopic children

      Purpose To assess the superficial retinal vessel density (SRVD) and foveal avascular zone (FAZ) in myopic children using optical coherence tomography angiography (OCTA). Methods 174 eyes of 89 subjects with myopia and 101 eyes of 54 age-matched, emmetropic volunteers (control group) were enrolled in this study. The mean age of the subjects and controls was 13.9 (SD ± 2.3) and 13.1 (SD ± 2.4), respectively. Myopia was defined as spherical equivalent <– 1.0 diopter. Emmetropic subjects were defined as having spherical equivalent from + 0.5 to − 0.5 diopter. The mean axial length (AL) in myopic patients was ...

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