1. Articles in category: Ophthalmology

    49-72 of 14575 « 1 2 3 4 5 6 ... 606 607 608 »
    1. Optical Coherence Tomography Guided Conjunctival Tick Infestation Treatment: A Case Report

      Optical Coherence Tomography Guided Conjunctival Tick Infestation Treatment: A Case Report

      Conjunctival infestation of ticks is not a common event, even in endemic regions. We presented a case of conjunctival tick attachment treatment guided by spectral domain optical coherence tomography (SD-OCT). This patient experienced a two-day history of pain, itching and redness in the right eye. Anterior segment examination revealed a tick body in the lower bulbar conjunctiva. No invasion of the sclera was confirmed with anterior segment SD-OCT. Tick was removed with conjunctival excision. We would like to state that the use of SD-OCT can be useful in clinical practice for safe and complete removal of conjunctival ticks.

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    2. OCTA Assessment of the Diabetic Macula: a Comparison Study among Different Algorithms

      OCTA Assessment of the Diabetic Macula: a Comparison Study among Different Algorithms

      Purpose: To assess the impact of histogram adjustments and binarization thresholding selection on quantitative measurements of diabetic macular ischemia using optical coherence tomography angiography (OCTA). Methods: Patients with diabetic retinopathy (DR) who had swept-source OCTA imaging obtained were enrolled. An additional group of 15 healthy control subjects was included for comparison. Previously employed brightness/contrast changes and binarization thresholds were applied to original OCTA images in order to obtain and compare different binarized images. Qualitative and quantitative comparisons were performed. Results: Thirty patients with DR (30 eyes) were included in the analysis. Fifteen eyes displayed the presence of diabetic macular ...

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    3. A sharper look at the interior of semiconductors

      A sharper look at the interior of semiconductors

      Images provide information—what we can observe with our own eyes enables us to understand. Constantly expanding the field of perception into dimensions that are initially hidden from the naked eye, drives science forward. Today, increasingly powerful microscopes let us see into the cells and tissues of living organisms, into the world of microorganisms as well as into inanimate nature. But even the best microscopes have their limits. "To be able to observe structures and processes down to the nanoscale level and below, we need new methods and technologies," says Dr. Silvio Fuchs from the Institute of Optics and Quantum ...

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    4. Optical Coherence Tomography Angiography Findings After Intravitreal Ranibizumab in Patients With Coats Disease

      Optical Coherence Tomography Angiography Findings After Intravitreal Ranibizumab in Patients With Coats Disease

      The aim of this retrospective study was to describe the vascular features in eyes with Coats disease, using optical coherence tomography angiography (OCTA), at baseline and after 3 monthly intravitreal injections of ranibizumab. Fifteen eyes of 15 consecutive patients affected by Coats' disease were recruited in this study. All patients underwent the best-corrected visual acuity (BCVA) evaluation, fundus examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), multicolor imaging, structural Spectral Domain (SD)-OCT and OCTA at baseline and 1 month after the third monthly ranibizumab injection (loading phase). Fifteen patients completed the study, of whom nine were males and six ...

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    5. Clinical Utility of Artificial Intelligence Algorithms to Enhance Wide-Field Optical Coherence Tomography Angiography Images

      Clinical Utility of Artificial Intelligence Algorithms to Enhance Wide-Field Optical Coherence Tomography Angiography Images

      The aim of this paper is to investigate the clinical utility of the application of deep learning denoise algorithms on standard wide-field Optical Coherence Tomography Angiography (OCT-A) images. This was a retrospective case-series assessing forty-nine 10 × 10 mm OCT-A1 macula scans of 49 consecutive patients attending a medical retina clinic over a 6-month period. Thirty-seven patients had pathology; 13 had none. Retinal vascular layers were categorised into superficial or deep capillary plexus. For each category, the retinal experts compared the original standard image with the same image that had intelligent denoise applied. When analysing the Superficial Capillary Plexus (SCP), the ...

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    6. Adjustment of intraocular lens tilt during intrascleral fixation assisted by intraoperative optical coherence tomography

      Adjustment of intraocular lens tilt during intrascleral fixation assisted by intraoperative optical coherence tomography

      Purpose: To evaluate the efficacy of using intraoperative optical coherence tomography (OCT) to adjust the tilting of an intraocular lens (IOL) during implantation with intrascleral fixation. Setting: Kyorin University Hospital, Tokyo, Japan. Design: Retrospective, case-control single-center study. Methods: Thirty-seven eyes of 37 patients who had undergone pars plana vitrectomy with intrascleral fixation of an IOL by a single surgeon were retrospectively studied. Intraoperative cross-sectional OCT (RESCAN 700, Carl Zeiss Meditec) scans were used to adjust the degree of IOL tilt in 23 eyes (iOCT group) and not used in 14 eyes (control group). The length of the externalized haptics was ...

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    7. Real-time intraoperative optical coherence tomography imaging of the vitreolenticular interface during pediatric cataract surgery

      Real-time intraoperative optical coherence tomography imaging of the vitreolenticular interface during pediatric cataract surgery

      PURPOSE: To report on the use of intraoperative optical coherence tomography (OCT) imaging of the vitreolenticular interface (VLI) during pediatric cataract surgery. To determine the incidence of VLI dysgenesis and surgical difficulties. SETTING: Department of Ophthalmology, Antwerp University Hospital, Belgium. DESIGN: Retrospective cohort study. METHODS: This study included 51 pediatric patients who underwent cataract surgery between April 2016 and December 2018. Video recordings and OCT images of the VLI were analyzed and compared. VLI dysgenesis was considered present when intraoperative OCT images demonstrated partial or total adhesions between the posterior lens capsule and the anterior hyaloid membrane. Video recordings were ...

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    8. ANALYSIS OF CONJUNCTIVAL VASCULAR DENSITY IN SCLERAL CONTACT LENS WEARERS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      ANALYSIS OF CONJUNCTIVAL VASCULAR DENSITY IN SCLERAL CONTACT LENS WEARERS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose To investigate conjunctival vascular density (VD) using Anterior Segment Optical Coherence Tomography Angiography (OCTA) in Scleral Contact Lens (ScCL) wearers. Methods In this cross-sectional study, the conjunctival blood VD was assessed using OCTA with an anterior segment lens adapter. The nasal surface of each eye (6 ×6 mm) was scanned to a depth of 800 μm with ScCL and fifteen minutes after removing the lens. Conjunctival VD was defined as the percentage of the scanned volume occupied by vessels in which blood flow was measured. Measures of limbal indentation were subjectively determined by two independent observers using Anterior Segment ...

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    9. Study of retinal structural–functional relationship in choroideremia using fundus autofluorescence and optical coherence tomography

      Study of retinal structural–functional relationship in choroideremia using fundus autofluorescence and optical coherence tomography

      Objective The objective of this study was to assess the structural–functional relationship in choroideremia (CHM) patients using optical coherence tomography (OCT) and autofluorescence (AF) images. Methods In this study, 53 eyes of 28 CHM patients were included. Demographic, ocular and clinical fundus features were recorded. Fundus AF and OCT images were analysed. Patients were classified into two groups based on AF features: group 1, CHM patients where the foveal island was present and group 2, CHM patients where the foveal island was absent. Inner and outer retinal layer thicknesses, retinal pigment epithelium (RPE) and subfoveal choroidal thickness (SFCT) were ...

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    10. Automated retinal layer segmentation on optical coherence tomography image by combination of structure interpolation and lateral mean filtering

      Automated retinal layer segmentation on optical coherence tomography image by combination of structure interpolation and lateral mean filtering

      Segmentation of layers in retinal images obtained by optical coherence tomography (OCT) has become an important clinical tool to diagnose ophthalmic diseases. However, due to the susceptibility to speckle noise and shadow of blood vessels etc., the layer segmentation technology based on a single image still fail to reach a satisfactory level. We propose a combination method of structure interpolation and lateral mean filtering (SI-LMF) to improve the signal-to-noise ratio based on one retinal image. Before performing one-dimensional lateral mean filtering to remove noise, structure interpolation was operated to eliminate thickness fluctuations. Then, we used boundary growth method to identify ...

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    11. Robust three-dimensional registration on optical coherence tomography angiography for speckle reduction and visualization

      Robust three-dimensional registration on optical coherence tomography angiography for speckle reduction and visualization

      Background: In the clinical applications of optical coherence tomography angiography (OCTA), the repeated scanning and averaging method can provide better contrast with reduced speckle noises in the final results, which are useful for visualizing and quantifying vascular components with high accuracy, reproducibility, and reliability. However, the inevitable patient motion presents a challenge to this method. The objective of this study is to meet this challenge by introducing a 3D registration method to register optical coherence tomography (OCT)/OCTA scans for precise volume averaging of multiple scans to improve the signal-to-noise ratio (SNR) and increase quantification accuracy. Methods: The proposed method ...

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    12. A Wide-Field Optical Coherence Tomography Normative Database Considering the Fovea-Disc Relationship for Glaucoma Detection

      A Wide-Field Optical Coherence Tomography Normative Database Considering the Fovea-Disc Relationship for Glaucoma Detection

      Purpose : One purpose of this study was to collect wide-field swept-source optical coherence tomography (SS-OCT) data from healthy eyes and build a wide-filed normative database. Another purpose was to compare the glaucoma diagnostic ability of new parameters based on this normative database to the parameters that are currently in use, such as the peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell-inner plexiform layer, and ganglion cell complex (GCC) thickness. Methods : This study had 220 healthy eyes and 292 eyes with early-stage glaucoma (EG) and moderate-stage glaucoma (MG) enrolled. Using the wide-field SS-OCT images (12 × 9 mm) of healthy eyes ...

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    13. Wide-Field Swept-Source Optical Coherence Tomography Angiography Analysis of the Periarterial Capillary-Free Zone in Branch Retinal Vein Occlusion

      Wide-Field Swept-Source Optical Coherence Tomography Angiography Analysis of the Periarterial Capillary-Free Zone in Branch Retinal Vein Occlusion

      Purpose : To investigate the characteristics of the retinal periarterial capillary-free zone (paCFZ) with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in eyes with branch retinal vein occlusion (BRVO). Methods : Seventy treatment-naïve eyes with BRVO and 35 healthy eyes were included. The paCFZ areas, artery calibers, and areas of the major arteries in the unaffected quadrants of BRVO eyes were measured in 12 × 12-mm SS-OCTA images and compared with those of the contralateral eyes and healthy eyes. Other multimodal imaging data were collected. Results : There were no significant differences in the unaffected artery caliber or area among the three groups ...

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      Mentions: Fudan University
    14. An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases

      An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases

      Purpose: This work aimed to examine the microvasculature of macular fibrosis in Coats disease. Methods: Three boys (aged 3, 4, and 6 years) with Coats disease (stages 2B to 3A2) and macular fibrotic nodules were imaged using optical coherence tomography angiography (OCTA) on the Spectralis spectral-domain OCT tabletop and investigational portable Spectralis Flex module (version 6.9, Heidelberg Engineering). Results: In 2 eyes, a neovascular complex was observed in the avascular slab on OCTA. This neovascular complex had vessels connected to diving vessels from the superficial vascular complex that traveled through the deep vascular complex to the avascular complex. In ...

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    15. Automatic screening of tear meniscus from lacrimal duct obstructions using anterior segment optical coherence tomography images by deep learning

      Automatic screening of tear meniscus from lacrimal duct obstructions using anterior segment optical coherence tomography images by deep learning

      Purpose We assessed the ability of deep learning (DL) models to distinguish between tear meniscus of lacrimal duct obstruction (LDO) patients and normal subjects using anterior segment optical coherence tomography (ASOCT) images. Methods The study included 117 ASOCT images (19 men and 98 women; mean age, 66.6 ± 13.6 years) from 101 LDO patients and 113 ASOCT images (29 men and 84 women; mean age, 38.3 ± 19.9 years) from 71 normal subjects. We trained to construct 9 single and 502 ensemble DL models with 9 different network structures, and calculated the area under the curve (AUC), sensitivity ...

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    16. Back-calculation of keratometer index based on OCT data and raytracing - a Monte Carlo simulation

      Back-calculation of keratometer index based on OCT data and raytracing - a Monte Carlo simulation

      Purpose: This study aims to develop a raytracing-based strategy for calculating corneal power from anterior segment optical coherence tomography data and extracting the individual keratometer index, which converts the corneal front surface radius to corneal power. Methods: A large OCT dataset (10,218 eyes of 8,430 patients) from the Casia 2 (Tomey, Japan) was post-processed in MATLAB (MathWorks, USA). Radius of curvature, asphericity of the corneal front and back surface, central corneal thickness and pupil size (aperture) were used to trace a bundle of rays through the cornea and derive the best focus plane. Corneal power was calculated with ...

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    17. Retinal cross‐section motion correction in three‐dimensional retinal optical coherence tomography

      Retinal cross‐section motion correction in three‐dimensional retinal optical coherence tomography

      Motion correction is an important issue in ophthalmic optical coherence tomography (OCT), and can improve the ability of datasets to reflect the physiological structures of tissues and make visualization and subsequent analysis easier. In this study, we present a novel method to correct the cross-sectional motion artifacts in retinal OCT volumes. Motion along the x-direction (fast-scan direction) is corrected through the normalized cross-correlation algorithm, while axial motion compensation is performed using the polynomial fitting method on the inner segment/outer segment (IS/OS) layer segmented by the shortest path faster algorithm (SPFA). The results of volunteers with central serous chorioretinopathy ...

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    18. Association between Optical Coherence Tomography Measurements and Clinical Parameters in Idiopathic Intracranial Hypertension

      Association between Optical Coherence Tomography Measurements and Clinical Parameters in Idiopathic Intracranial Hypertension

      Purpose: To correlate optical coherence tomography (OCT) measurements with clinical parameters in idiopathic intracranial hypertension (IIH). Methods: A cross-sectional study was conducted with 22 patients with IIH and 11 controls. All participants underwent comprehensive ophthalmological examination followed by spectral-domain OCT (SD-OCT) and standard automated perimetry using the 30-2 program of the Humphrey visual field analyzer. Correlations between ganglion cell complex (GCC) thickness and retinal nerve fiber layer (RNFL) thickness, as measured by SD-OCT, and clinical parameters were assessed using generalized estimating equations. Result: The mean age of the participants was 35.0 ± 10.83 years. The groups were similar regarding ...

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    19. Quantitative assessment of vascular density in diabetic retinopathy subtypes with optical coherence tomography angiography

      Quantitative assessment of vascular density in diabetic retinopathy subtypes with optical coherence tomography angiography

      Background: Quantitative assessment of vascular density (VD) of retinal and choriocapillaris (CC) in various stages of diabetic retinopathy (DR) using spectral domain optical coherence tomography angiography (SD OCTA). Methods: 188 eyes of 97 participants were recruited in this cross-sectional study. The macular OCTA (3x3mm) scan was performed and the computer algorithm assessed VD at the level of superficial capillary plexus (SCP), deep capillary plexus (DCP) and CC. Results: All measured parameters were decreased in retinal VD at the more extreme stages of DR, with the exception of SCP foveal VD. There was a constant pattern of decrease in VD of ...

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    20. Agreement Between Angle-to-Angle Distance and Aqueous Depth Obtained With Two Different Optical Coherence Tomographers and a Scheimpflug Camera

      Agreement Between Angle-to-Angle Distance and Aqueous Depth Obtained With Two Different Optical Coherence Tomographers and a Scheimpflug Camera

      PURPOSE: To compare angle-to-angle (ATA) distance and aqueous depth (AQD) readings produced by two different optical coherence tomography (OCT) devices and a Scheimpflug camera. METHODS: ATA distance and AQD were measured in 60 eyes using the Visante time-domain OCT (TD-OCT) (Carl Zeiss Meditec AG), the Anterion swept-source OCT (SS-OCT) (Heidelberg Engineering GmbH), and the Pentacam HR Scheimpflug camera (Oculus Optikgeräte GmbH). Moreover, ATA distance was measured along the horizontal and vertical meridians. Bland-Altman analysis was used to assess the agreement between devices. RESULTS: All three devices did not yield similar horizontal ATA distance: 11.96 ± 0.47 mm (TD-OCT ...

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    21. Discordance in Retinal and Choroidal Vascular Densities in Patients with Type 2 Diabetes Mellitus on Optical Coherence Tomography Angiography

      Discordance in Retinal and Choroidal Vascular Densities in Patients with Type 2 Diabetes Mellitus on Optical Coherence Tomography Angiography

      Purpose . In the present study, the retinal and choroidal vascular densities (VDs) in type 2 diabetes mellitus (DM) patients were analyzed using optical coherence tomography angiography (OCTA). Methods . The study included 282 eyes of 152 patients with type 2 DM (114 without retinopathy, 79 nonproliferative diabetic retinopathy (NPDR), 48 severe NPDR, and 41 proliferative diabetic retinopathy (PDR) eyes). The superficial and deep retinal vessel, choriocapillaris, and choroidal VDs were measured using a binarization method on OCTA images. VDs were compared based on retinopathy severity. Correlations among densities were analyzed. Results . Retinal and choriocapillaris VDs were lower in PDR than in ...

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    22. Correlations Between Retinal Optical Coherence Tomography and Histopathology in Preclinical Safety Assessment of Ocular Therapies

      Correlations Between Retinal Optical Coherence Tomography and Histopathology in Preclinical Safety Assessment of Ocular Therapies

      Methods: Twelve studies that involved intravitreal or subretinal test article administration in multiple laboratory animal species and employed both OCT and histopathologic assessment were identified. These data were compared to determine the degree of correlation for each identified abnormality. Results: Severity of observed OCT and histopathological changes ranged from minimal to severe, with moderate and severe changes having a higher rate of agreement between the 2 techniques. Changes to well-defined structures, including the retinal blood vessels, optic nerve, and retinal pigment epithelium, also showed a strong correlation. Conclusions: There was a strong correlation between OCT and histopathology in both intravitreal ...

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    23. Vessel density in early-stage primary open angle glaucoma and pseudoexfoliation glaucoma: a comparative controlled optical coherence tomography angiography study

      Vessel density in early-stage primary open angle glaucoma and pseudoexfoliation glaucoma: a comparative controlled optical coherence tomography angiography study

      Purpose: This study aimed to compare the vessel density of the optic nerve head and radial peripapillary capillary in the eyes with early-stage primary open angle glaucoma and pseudoexfoliation glaucoma and control eyes. Methods: With visual field mean deviation scores >-6.0 dB, 54 eyes from 37 patients diagnosed with primary open angle glaucoma (n=18) and pseudoexfoliation glaucoma (n=18) and healthy controls (n=18) were enrolled in this cross-sectional observational study. Retrieved from optical coherence tomography angiography, vessel density for the optic nerve head and radial peripapillary capillary were analyzed according to the distribution of the data and ...

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    24. Investigation of Retinal Vascular Changes during Pregnancy Using Optical Coherence Tomography Angiography

      Investigation of Retinal Vascular Changes during Pregnancy Using Optical Coherence Tomography Angiography

      Purpose : To investigate retinal vascular changes in pregnant women using optical coherence tomography angiography (OCTA). Materials and Methods : This prospective, cross-sectional study included 97 pregnant women and age-matched 34 healthy control subjects. The OCTA parameters of one eye (left) of pregnancy group and control group were compared. Besides, the OCTA parameters of three trimesters were compared between themselves and the control group. The foveal avascular zone (FAZ) area and the vessel density percentages of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and radial peripapillary capillary (RPC) of all the groups were evaluated by OCTA. Results : In the pregnancy ...

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