1. Articles in category: Ophthalmology

    49-72 of 12918 « 1 2 3 4 5 6 ... 537 538 539 »
    1. Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions

      Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions

      A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diagnose glaucoma. The objective of this work was to review and analyse the discriminative capacity of vascular density, retrieved from different ROIs, on differentiating healthy subjects from glaucoma patients. PubMed was used to perform a systematic review on the analysis of glaucomatous vascular damage using OCTA. All studies up to 21 April 2019 were ...

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    2. Study of vessel density by optical coherence tomography angiography in patients with central serous chorioretinopathy after low-fluence photodynamic therapy

      Study of vessel density by optical coherence tomography angiography in patients with central serous chorioretinopathy after low-fluence photodynamic therapy

      Background To perform a quantitative analysis of retinal and choriocapillaris vessel density (VD) in patients with central serous chorioretinopathy (CSC) after low-fluence verteporfin photodynamic therapy (vPDT), using Optical Coherence Tomography Angiography (OCTA). Methods A total of 28 eyes of 27 patients with CSC (21 females, 6 males, mean age 47 ± 11 years) were included in this retrospective study. At baseline and after 6 months after vPDT, we evaluated VD of the superficial capillary plexus (SCP), the deep capillary plexus (DCP) and the choriocapillaris (CC) in different macular areas (whole image, parafovea and fovea). We also analyzed the central foveal thickness ...

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    3. Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice

      Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice

      Purpose : The retinal phenotype of popular mouse models mimicking ophthalmic diseases, such as the superoxide dismutase 1 (SOD1) knockout (KO) mouse model, has mainly been assessed by ex vivo histology and in vivo fundus photography. We used multifunctional optical coherence tomography (OCT) to characterize the retinas of SOD1 KO mice in vivo. Methods : The custom-made ophthalmoscope featured a combination of conventional OCT, polarization-sensitive OCT, and OCT angiography. Seven SOD1 KO mice and nine age-matched controls were imaged between 6 and 17 months of age. A postprocessing framework was used to analyze total and outer retinal thickness changes. Drusenlike lesions were ...

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    4. INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY AND ENDOSCOPY-GUIDED EXPLANTATION OF ARGUS II DEVIC

      INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY AND ENDOSCOPY-GUIDED EXPLANTATION OF ARGUS II DEVIC

      Purpose: To describe a surgical approach using intraoperative optical coherence tomography and endoscopy for successful Argus II retinal prosthesis system removal. Methods: Retrospective review of a patient undergoing Argus II explantation 8 months after initial implantation. Results: Successful explantation of the Argus II device was performed in this patient. Conclusion: Explantation of the Argus II device can be a difficult surgery, and intraoperative optical coherence tomography and endoscopy can be used to help avoid potential complications.

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      Mentions: Duke University
    5. Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis

      Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis

      Introduction For quantification of Optical Coherence Tomography Angiography (OCTA) images, Vessel Density (VD) and Vessel Skeleton Density (VSD) are well established parameters and different algorithms are in use for their calculation. However, comparability, reliability and ability to discriminate healthy and impaired macular perfusion of different algorithms are unclear, yet, of potential high clinical relevance. Hence, we assessed comparability and test-retest reliability of the most common approaches. Materials and methods Two consecutive 3×3mm OCTA en face images of the superficial and deep retinal layer were acquired with swept-source OCTA. VD and VSD were calculated with manual thresholding and six automated ...

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    6. Different Scan Protocols Affect the Detection Rates of Diabetic Retinopathy Lesions by Wide-field Swept-Source Optical Coherence Tomography Angiography

      Different Scan Protocols Affect the Detection Rates of Diabetic Retinopathy Lesions by Wide-field Swept-Source Optical Coherence Tomography Angiography

      Purpose To compare different scan protocols of wide field swept-source optical coherence tomography angiography (SS-OCTA) for the detection of diabetic retinopathy (DR) lesions. Design Comparison of diagnostic approaches. Methods A prospective, observational study was conducted at Mass Eye and Ear from December 2018 to July 2019. Proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR) and diabetic patients without DR were included. All patients were imaged with a SS-OCTA using following scan protocol: Angio 3mm×3mm centered on fovea, Angio 6mm×6mm centered on fovea and optic disc, Montage 15mm×9mm and Angio 12mm×12mm centered on fovea and optic disc ...

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    7. Recent developments in pediatric retina

      Recent developments in pediatric retina

      Purpose of review Pediatric retina is an exciting, but also challenging field, where patient age and cooperation can limit ease of diagnosis of a broad range of congenital and acquired diseases, inherited retinal degenerations are mostly untreatable and surgical outcomes can be quite different from those for adults. This review aims to highlight some recent advances and trends that are improving our ability to care for children with retinal conditions. Recent findings Studies have demonstrated the feasibility of multimodal imaging even in nonsedated infants, with portable optical coherence tomography (OCT) and OCT angiography in particular offering structural insights into diverse ...

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      Mentions: Duke University
    8. Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration

      Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration

      Purpose Anti-VEGF treatment of neovascular age-related macular degeneration (AMD) is a highly effective advance in the retinal armentarium. Optical coherence tomography (OCT) offering three-dimensional imaging of the retina is widely used to guide treatment. Although poor outcomes reported from clinical practice are multifactorial, availability of reliable, reproducible, and quantitative evaluation tools to accurately measure the fluid response i.e. a “VEGF meter” may be a better means of monitoring and treating than the current purely qualitative evaluation used in clinical practice. Design Post-hoc analysis of a phase III, randomized, multicenter study. Participants Study eyes of 1095 treatment-naive subjects receiving pro-re-nata ...

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    9. Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography

      Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography

      Cynomolgus macaques are an important and commonly used species in preclinical toxicology studies, but structural reports of in vivo retinal findings are rare in this species. The purpose of this study was to diminish this gap and document optical coherence tomography and scanning laser ophthalmoscopy imaging data in the healthy posterior pole of cynomolgus monkeys’ eyes at predose examinations. The current study is a retrospective assessment of baseline spectral domain OCT data obtained from the 768 eyes of 384 cynomolgus monkeys (192 males and 192 females) of Mauritian origin. The data set was obtained from studies conducted over a 4-y ...

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    10. Macular optical coherence tomography findings after vitreoretinal surgery for rhegmatogenous retinal detachment

      Macular optical coherence tomography findings after vitreoretinal surgery for rhegmatogenous retinal detachment

      The primary aim of this study was to summarize and illustrate the main structural cross-sectional optical coherence tomography findings encountered after vitreoretinal surgery for rhegmatogenous retinal detachment. This was a non-systematic review of literature on structural cross-sectional optical coherence tomography findings after vitreoretinal surgery for rhegmatogenous retinal detachment. Adequate illustrations of the main findings described were found after a retrospective analysis of imaging and charts of patients operated at the department where this study was performed. The main structural cross-sectional optical coherence tomography findings after vitreoretinal surgery for rhegmatogenous retinal detachment included persistent subretinal fluid, subretinal blebs, retinal folds, subretinal ...

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    11. Macular Imaging with Optical Coherence Tomography in Glaucoma

      Macular Imaging with Optical Coherence Tomography in Glaucoma

      With the advent of spectral-domain optical coherence tomography (SD-OCT), imaging of the posterior segment of the eye can be carried out rapidly at multiple anatomical locations, including the optic nerve head (ONH), circumpapillary retinal nerve fiber layer (cp-RNFL), and macula. There is now ample evidence to support the role of SD-OCT imaging of the macula for detection of early glaucoma. Macular SD-OCT measurements demonstrate high reproducibility, and evidence on its utility for detection of glaucoma progression is accumulating. We present a comprehensive review of macular SD-OCT imaging emerging as an essential diagnostic tool in glaucoma.

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    12. Visual Field Cluster Map Corresponding to Bruch’s Membrane Opening-Minimum Rim Area Sectors in Open-Angle Glaucoma

      Visual Field Cluster Map Corresponding to Bruch’s Membrane Opening-Minimum Rim Area Sectors in Open-Angle Glaucoma

      Précis: We generated a new visual field cluster map corresponding to Bruch’s membrane opening-minimum rim area sectors, which described in detail the structure-function relationships between the optic nerve head and visual field in patients with open-angle glaucoma . Purpose: To investigate the structure-function relationship between Bruch’s membrane opening-minimum rim area (BMO-MRA) and visual field (VF) in patients with open-angle glaucoma . Methods: We retrospectively reviewed 67 eyes of 50 patients with open-angle glaucoma who underwent spectral-domain optical coherence tomography for BMO-MRA and Humphrey VF test. BMO-MRA of the glaucomatous optic nerve head was divided into 12 sectors. The correlation ...

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    13. A Semi-Automatic Software for Segmentation and Feature Extraction from Optical Coherence Tomography Images (Semi SFE)

      A Semi-Automatic Software for Segmentation and Feature Extraction from Optical Coherence Tomography Images (Semi SFE)

      The Ophthalmology Science has recently witnessed marked progress due to the advent of divergent imaging techniques, especially Optical Coherence Tomography which has caught many physicians’ attention for being exact, rapid, non-invasive and low-cost. In this paper, we wish to solve the difficulties associated with OCT image segmentation by offering a handy software written in the MATLAB [1] App Designer environment which helps researchers and clinicians to easily segment the images, save the numerical outcomes and send them for proper analysis. Serving an unambiguous user interface along with a unified platform in which all necessary functions have been incorporated graphically has ...

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    14. Retinal microvascular attenuation in mental cognitive impairment and Alzheimer's disease by optical coherence tomography angiography

      Retinal microvascular attenuation in mental cognitive impairment and Alzheimer's disease by optical coherence tomography angiography

      Purpose To explore regional variation of the macular microvasculature in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), also to detect the association between retinal macular microvascular parameters and the progress of preclinical AD. Methods Prospective study of healthy controls, patients with MCI and patients with AD by using Optical coherence tomography angiography (OCT‐A). We quantified foveal avascular zone (FAZ) areas, densities of the superficial retinal capillary plexuses (SRCP) and deep retinal capillary plexuses (DRCP). The SRCP and DRCP were divided into inner (3 mm) and external (6 mm) annular rings, each containing four quadrants (SI ...

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    15. UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

      UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

      University of Illinois at Urbana-Champaign Receives a 2020 NIH Grant for $445,996 for A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD). The principal investigator is Liang Gao. Below is a summary of the proposed work. An imaging modality that allows for fast, simultaneous, noninvasive probing of both 3D cellular resolution retinal morphology by optical coherence tomography (OCT) and molecular-specific functions by autofluorescence (AF) could substantially improve both basic understanding and the early diagnosis of age- related macular degeneration (AMD), the leading cause of blindness in the developed world. The evaluation and management of ...

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    16. Bulk motion subtraction in optical coherence tomography angiography

      Bulk motion subtraction in optical coherence tomography angiography

      Described herein is an algorithm to remove decorrelation noise due to bulk motion in optical coherence tomography angiography (OCTA). OCTA B-frames are divided into segments within which the bulk motion velocity could be assumed constant. This velocity is recovered using linear regression of decorrelation versus the logarithm of reflectance in axial lines (A-lines) identified as bulk tissue by percentile analysis. The fitting parameters are used to calculate a reflectance-adjusted threshold for bulk motion decorrelation. Below this threshold, voxels are identified as non-flow tissue, and their flow values are set to zeros. Above this threshold, the voxels are identified as flow ...

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    17. Special Issue "Development and Application of Imaging Analysis in Ocular Diseases"

      Special Issue "Development and Application of Imaging Analysis in Ocular Diseases"

      Dear Colleagues, The eye is a complex organ that is capable of turning light into sight, allowing us to interpret our surroundings by working similarly to the conventional camera, which gathers, focuses, and transmits light through a lens. Various analyses relying on image-processing algorithms have been proposed to efficiently examine subtle changes in the eye to diagnose ocular diseases. Also, numerous studies have shown that the vessels and neural layers in the eye reflect what is going on in other organs, specifically the heart and brain. Images from the eye have become enormous troves of data for algorithm development in ...

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    18. Measurement of the Lower Lid Margin Thickness by Anterior Segment Optical Coherence Tomography

      Measurement of the Lower Lid Margin Thickness by Anterior Segment Optical Coherence Tomography

      Purpose: To verify the feasibility of using anterior segment optical coherence tomography (AS-OCT) to measure the lower lid margin thickness (LLMT) from posterior lash line to the mucocutaneous junction. Methods: This was a prospective, single center, observational study. Fifty-six volunteers between 20 and 79 years old with normal healthy eyes were included in this study. Using AS-OCT to measure the LLMT at the middle position was separately performed by two operators under the same conditions. Results: The mean age of 56 subjects (24 males and 32 females) was 45.4 ± 15.7 years. The LLMT measured by AS-OCT between two ...

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    19. Multimodal Imaging in Ocular Toxoplasmosis

      Multimodal Imaging in Ocular Toxoplasmosis

      Multimodal imaging relies on combination of multiple imaging modalities to precisely delineate pathological changes in the posterior segment of the eye associated with a wide range of conditions. This combined application of fundus photography, optical coherence tomography, fundus reflectance/autofluorescence and fundus angiography (with fluorescein, indocyanine green and/or optical coherence tomography) is of great utility for assessment of patients with ocular toxoplasmosis. Multimodal imaging is helpful to characterize the typical pattern of toxoplasmic retinochoroiditis, with primary focal inflammatory involvement of the neurosensory retina, and secondary changes at the level of underlying choroid, retinal blood vessels, vitreous and even optic ...

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    20. Assessment of superficial and deep retinal vessel density in systemic lupus erythematosus patients using optical coherence tomography angiography

      Assessment of superficial and deep retinal vessel density in systemic lupus erythematosus patients using optical coherence tomography angiography

      Purpose The aim of this study is to evaluate the retinal microvascular density in SLE patients using optical coherence tomography angiography (OCTA) and to correlate vascular density with the disease activity and damage risk. Methods Twenty eyes of 20 SLE patients were compared with 20 eyes of normal subjects. The retinal capillary plexuses were examined by OCTA. The disease activity and damage risk were evaluated by the SLEDAI-2 K and SLICC/ACR SDI scoring systems. Results No difference was found between SLE patients’ central foveal thickness (CFT) and foveal avascular zone (FAZ) area and the normal ( P  > 0.05). SLE ...

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    21. Features of neovascularization in pachychoroid neovasculopathy compared with type 1 neovascular age-related macular degeneration on optical coherence tomography angiography

      Features of neovascularization in pachychoroid neovasculopathy compared with type 1 neovascular age-related macular degeneration on optical coherence tomography angiography

      Purpose To compare neovascular membrane features of pachychoroid neovasculopathy (PNV) and type 1 neovascular age-related macular degeneration (nAMD) using optical coherence tomography angiography (OCTA). Design Retrospective study. Methods We assessed 34 treatment-naïve eyes with a diagnosis of PNV and 36 treatment-naïve eyes with a diagnosis of type 1 nAMD. Morphological patterns of neovascular membranes were categorized, and lesion sizes and flow areas were calculated by using en face images on the AngioVue (Optovue) OCTA system. Results Statistically significant differences were found between groups in age ( P =0.001), baseline best corrected visual acuity ( P =0.005), and baseline ...

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    49-72 of 12918 « 1 2 3 4 5 6 ... 537 538 539 »
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