1. Articles in category: Ophthalmology

    49-72 of 12085 « 1 2 3 4 5 6 ... 502 503 504 »
    1. Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Purpose : To analyze the evolution of type 1 neovascularization associated with vascularized serous pigment epithelial detachment (vsPED) using three-dimensional, volumetric, en face optical coherence tomography angiography (OCTA). Methods : This was a retrospective case series from four tertiary medical centers. OCTA images were analyzed at baseline and at the 3-, 6-, 12-, 18-, and 24-month follow-up visit when available. Visual acuity, number of injections, PED maximal height and PED area and volume, and choroidal neovascularization (CNV) flow area and progression were determined at each visit. Qualitative and quantitative analysis of CNV progression (including CNV/PED flow area) and final PED morphology ...

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    2. Prognostic role of optical coherence tomography after switch to dexamethasone in diabetic macular edema

      Prognostic role of optical coherence tomography after switch to dexamethasone in diabetic macular edema

      Aims To analyze the visual outcome after early switch to dexamethasone (DEX) in eyes with diabetic macular edema previously treated with ranibizumab (RNB), based on structural spectral-domain optical coherence tomography (SD-OCT) features. Methods Retrospective study of data from 28 eyes which underwent a loading dose of three monthly RNB injections and were then shifted to DEX implant injection. SD-OCT analysis was performed before switch to DEX (week 12, 12W) according to the presence of integrity of ellipsoid zone (EZ) and external limiting membrane (ELM), disorganization of retinal inner layers (DRIL), and quantity of hyper-reflective spots (HRS). Best-corrected visual acuity (BCVA ...

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    3. Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography

      Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography

      Purpose : Clinical evaluation of retinal pigment epithelium (RPE) change is important for the therapeutic management of chronic Vogt-Koyanagi-Harada (VKH) disease. We evaluated long-term change in the RPE layer in VKH disease, using near-infrared (NIR; 817 nm) images and autofluorescence images at 488 nm (short-wavelength [SW]-AF) and 785 nm (NIR-AF), and compared those images with images from multicontrast optical coherence tomography (MC-OCT). MC-OCT is capable of simultaneous measurement of OCT angiography, polarization-sensitive OCT, and standard OCT. Methods : We evaluated 24 eyes of 12 patients with chronic VKH disease. RPE changes were assessed using NIR, NIR-AF, SW-AF, and MC-OCT imaging performed ...

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    4. Measurement of Oral Epithelial Thickness by Optical Coherence Tomography

      Measurement of Oral Epithelial Thickness by Optical Coherence Tomography

      Optical coherence tomography (OCT) is a real-time, in-situ, non-invasive imaging device that is able to perform a cross-sectional evaluation of tissue microstructure based on the specific intensity of back-scattered and reflected light. The aim of the present study was to define normal values of epithelial thickness within the oral cavity. OCT measurements of epithelial thickness were performed in 28 healthy patients at six different locations within the oral cavity. Image analysis was performed using Image J 1.52 software. The healthy epithelium has a mean thickness of 335.59 ± 150.73 µm. According to its location within the oral cavity ...

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    5. OCT motion contrast data analysis apparatus and OCT motion contrast data analysis method

      OCT motion contrast data analysis apparatus and OCT motion contrast data analysis method

      An OCT motion contrast data analysis apparatus includes: a processor; and memory storing computer readable instructions, when executed by the processor, causing the OCT motion contrast data analysis apparatus to execute: acquiring OCT motion contrast data of a subject by an optical coherence tomography; and performing an analysis process with respect to the OCT motion contrast data based on an analysis chart set on image data different from the OCT motion contrast data.

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      Mentions: Nidek
    6. Methods and systems for combined morphological and angiographic analyses of retinal features

      Methods and systems for combined morphological and angiographic analyses of retinal features

      Methods and systems in ophthalmic imaging are presented that increase the sensitivity of automated diagnoses by the use of a combination of both functional and structural information derived from a variety of ophthalmic imaging modalities. An example method to analyze image data of an eye of a patient includes processing a first image dataset to obtain one or more functional metrics; processing a second image dataset to obtain one or more structural metrics; comparing the one or more structural metrics to the one or more functional metrics; and processing the results of said comparison to derive the probability of a ...

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    7. Computational Methods to Quantify Human Lens Shape and Optical Properties Using Laser Ray Tracing and Optical Coherence Tomography (Thesis)

      Computational Methods to Quantify Human Lens Shape and Optical Properties Using Laser Ray Tracing and Optical Coherence Tomography (Thesis)

      Vision is worsening on a global scale. Myopia, a visual condition where distant objects appear blurry, is increasing in prevalence at an alarming rate. This condition typically starts during childhood and progressively worsens, potentially leading to more severe visual conditions if left unchecked. Currently, the best treatment method to slow myopic progression is heavily debated as the etiology of myopia is not fully understood. The development of effective long-term solutions require a better understanding of how vision changes with age. The cornea and lens, the length of the human eye, and the surrounding ocular media dictate visual quality. Extensive studies ...

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    8. Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening

      Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening

      Optical Coherence Tomography (OCT) imaging plays an important role in glaucoma diagnosis in clinical practice. Early detection and timely treatment can prevent glaucoma patients from permanent vision loss. However, only a dearth of automated methods has been developed based on OCT images for glaucoma study. In this paper, we present a novel framework to effectively classify glaucoma OCT images from normal ones. A semi-supervised learning strategy with smoothness assumption is applied for surrogate assignment of missing function regression labels. Besides, the proposed multi-task learning network is capable of exploring the structure and function relationship from the OCT image and visual ...

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    9. Optical coherence tomography and cognitive dysfunction in Parkinson disease

      Optical coherence tomography and cognitive dysfunction in Parkinson disease

      Background Parkinson’s disease (PD) is a progressive neurodegenerative disease of aging. Optical coherence tomography (OCT) is a simple noninvasive imaging technique to estimate the retinal nerve fiber layer (RNFL) thickness. The aim of this study is to measure the changes of the RNFL thickness in patients with Parkinson disease in comparison with the control group and to detect the relationship between these changes in RNFL with cognitive functions and physical disability in Parkinson patients. Methods 20 PD patients (40 eyes) and 20 healthy persons (40 eyes) were enrolled according to the defined criteria. The diagnosis of the patient's ...

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    10. A Novel Use of Optical Coherence Tomography for the Assessment of Ocular Torsion (Thesis)

      A Novel Use of Optical Coherence Tomography for the Assessment of Ocular Torsion (Thesis)

      Abnormal ocular torsion is most frequently the result paresis of the fourth cranial nerve. The presence of torsion can be a barrier to fusion, in which case, surgical intervention is required for a patient to have single vision. Clinically, ocular torsion can be measured either subjectively or objectively, the latter traditionally using the relationship between the fovea and the optic disc. However, previous literature has shown inconsistencies between torsion a patient’s perceived subjective torsion, and the amount of anatomical fundus torsion. Therefore, the aim of the current study was to investigate the relationship of subjective and objective ocular torsion ...

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    11. Diagnostic Ability of Macular Vessel Density in the Ganglion Cell–Inner Plexiform Layer on Optical Coherence Tomographic Angiography for Glaucoma

      Diagnostic Ability of Macular Vessel Density in the Ganglion Cell–Inner Plexiform Layer on Optical Coherence Tomographic Angiography for Glaucoma

      Purpose : The purpose of this study was to analyze the macular vessel density layer-by-layer and compare the diagnostic value of each in diagnosing glaucoma. Methods : This was a prospective comparative cross-sectional study, and the setting was glaucoma referral practice. The study participants were patients with primary open-angle glaucoma undergoing treatment with drugs, and age-matched normal controls who visited our clinic for regular eye examinations for refractive errors. All participants were investigated using macular optical coherence tomographic angiography, fundus photography, and 24-2 visual field (VF) testing. Average vessel densities in the retinal nerve fiber–ganglion cell–inner plexiform layer (IPL), retinal ...

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    12. Deep Learning Based Fluid Segmentation in Retinal Optical Coherence Tomography Images

      Deep Learning Based Fluid Segmentation in Retinal Optical Coherence Tomography Images

      Macular Edema (ME) is the accumulation of fluid in the macular region of the eye, and it may lead to the distortion of center vision. It often occurs in diabetic retinopathy. It is important to measure fluid accumulation in ME patients for disease monitor. Segmentation of the fluid region in the retinal layer is an essential step for quantitatively analysis. However, manual segmentation is time consuming and also subjective. In this paper, a new deep learning based segmentation method is proposed. The attention mechanism is introduced to automatically locate the fluid region, which can reduce the number of parameters compared ...

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    13. Relationship of Posterior Capsular Opacification and Capsular Bend Type Investigation Based on Swept-source Optical Coherence Tomography

      Relationship of Posterior Capsular Opacification and Capsular Bend Type Investigation Based on Swept-source Optical Coherence Tomography

      Purpose : To investigate the relationship between capsular bend type and posterior capsule opacification (PCO) at a three-dimensional (3D) level using high-speed swept-source optical coherence tomography (SS-OCT). Methods : This was a retrospective study. A total of 99 eyes that underwent standard cataract surgery with phacoemulsification 2 years ago were analyzed. Standard SS-OCT radial scanning was performed in all eyes and the obtained photos were used for morphological observations of the capsular bend-IOL complex, the adhesion of posterior capsule to the IOL optic, and the position of the anterior capsulorhexis. Digital retroillumination photographs were taken of the posterior capsule of each eye ...

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    14. RETOUCH: The Retinal OCT Fluid Detection and Segmentation Benchmark and Challenge

      RETOUCH: The Retinal OCT Fluid Detection and Segmentation Benchmark and Challenge

      Retinal swelling due to the accumulation of fluid is associated with the most vision-threatening retinal diseases. Optical coherence tomography (OCT) is the current standard of care in assessing the presence and quantity of retinal fluid and image-guided treatment management. Deep learning methods have made their impact across medical imaging, and many retinal OCT analysis methods have been proposed. However, it is currently not clear how successful they are in interpreting the retinal fluid on OCT, which is due to the lack of standardized benchmarks. To address this, we organized a challenge RETOUCH in conjunction with MICCAI 2017, with eight teams ...

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    15. OCT Feasibility Older Hip Fracture

      OCT Feasibility Older Hip Fracture

      Optical coherent tomography (OCT) is a device used to achieve cross-sectional imaging of tissues. It is often used in ophthalmology and also has application in dermatology, cardiology and other specialities. Usually, in adults, a table-top device is used necessitating the transfer of patients to the location of the device. In children a hand held device is used meaning the device can be taken to the patients' location. To facilitate/ help design a future study, this study's aim is to assess the feasibility of achieving retinal imaging in older people who are recovering from hip fracture surgery using a hand ...

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    16. Average Lens Density Quantification With Swept Source OCT Integrated Into the Iolmaster 700: An Optimized and Automatized Version of the Technique for Cataract Grading

      Average Lens Density Quantification With Swept Source OCT Integrated Into the Iolmaster 700: An Optimized and Automatized Version of the Technique for Cataract Grading

      Purpose To assess an upgraded version of our objective cataract grading method based on lens densitometry on Swept-Source Optical Coherence Tomography (SS-OCT) scans provided by the IOLMaster 700. Settings Single centre study at the Rothschild Foundation, Paris, France. Design Prospective cross-sectional study Methods All patients consulting for cataract evaluation and consenting to study participation were included. History of previous ocular surgery, cornea or retina disorders, and ocular dryness were exclusion criteria. The average lens densitometry (ALD) was measured on SS-OCT scans provided by the IOLMaster 700 using our algorithm developed on MATLAB® software. The ocular scatter index (OSI) was measured ...

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    17. Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL in human eyes. From the segmentation, en face images of RNFL thickness and RNFL birefringence were created. The measured birefringence values are consistent with earlier reports.

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    18. En-face optical coherence tomography of unilateral myopic retinoschisis

      En-face optical coherence tomography of unilateral myopic retinoschisis

      A 56-year-old female presented with blurred vision in the right eye. Best corrected visual acuity was 6/18, N12 in the right eye and 6/6, N6 in the left eye. Fundus examination in both eyes showed significant tessellation. Spectral domain OCT revealed a split in the neurosensory retina at the level of Henle's layer nasal to fovea with schitic changes extending to fovea. En face OCT demonstrated a very characteristic half wheel or coral shaped pattern at the level of outer plexiform layer highlighting the complete extent of the retinoschisis [Figure 1] .

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    19. Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm

      Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm

      A 46-year-old male presented with best corrected visual acuity (BCVA) of 20/125 in his right eye. Fundus showed disc edema, multiple yellow outer retinal crops, macular edema and a live motile worm in the subretinal space. Diagnosis of diffuse unilateral subacute neuroretinitis (DUSN) was made and pattern scanning laser photocoagulation (PSLP) was performed along with administration of oral albendazole, diethylcarbamazine and corticosteroids. Complete disappearance of the worm was observed at 2 weeks. At last follow up, final BCVA improved to 20/30. Herein, we report role of PSLP in the management of DUSN.

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    20. Commentary: Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm

      Commentary: Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm

      Different nematodes have been associated with diffuse unilateral subacute neuroretinitis (DUSN) including Toxocara canis, Ancylostoma caninum, Strongyloides stercoralis, Ascaris lumbricoides , and Baylisascaris procyonis . [1] The clinical features of DUSN include subretinal tracks, small yellow-white spots on retina, altered internal limiting membrane (ILM) reflex, vitritis, vasculitis, retinal edema, live worm, alterations of the retinal pigment epithelium, narrowed retinal vessels, and optic disc atrophy especially in late phases. [2] The early signs of DUSN are often mistaken for entities that cause focal chorioretinitis, including toxoplasmosis, histoplasmosis, sarcoidosis, white dot syndromes, nonspecific optic neuritis, and papillitis. The late stage of DUSN is often ...

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    21. Structural-functional correlation using adaptive optics, visual fields, optical coherence tomography and multifocal electroretinogram in a case of torpedo maculopathy

      Structural-functional correlation using adaptive optics, visual fields, optical coherence tomography and multifocal electroretinogram in a case of torpedo maculopathy

      A 37-year-old man, diagnosed previously as a 'chorioretinal scar' in the macula, came for follow-up examination at our retina clinic. He had no ocular symptoms. Systemic history was normal. Eye examination revealed vision of 20/20 in both eyes. Anterior segment examination was normal in both eyes. Dilated fundus examination revealed pink and healthy optic nerves with normal physiologic cupping in each eye. Right eye macular examination revealed a classical, torpedo-shaped, hypopigmented chorioretinal lesion. Left eye macula was unremarkable. Peripheral retina was normal in both eyes. Multimodal imaging of the torpedo lesion was done with fundus autofluoroscence, fundus fluorescein angiography ...

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    22. Altris AI algorithm for retinal conditions detection on Optical Coherence Tomography (OCT) scans gets European CE-mark certification

      Altris AI algorithm for retinal conditions detection on Optical Coherence Tomography (OCT) scans gets European CE-mark certification

      Altris AI (Altris, Inc), a global artificial intelligence (AI) healthcare company, announced that it has received the CE Mark approval for its Standard Functionality for retinal conditions detection on Optical Coherence Tomography (OCT) scans. Altris AI Standard Functionality is ready for preliminary screening of retinal diseases in clinical practice. Altris AI detects retinal pathological signs of more than 30 retinal diseases and classifies them according to severities. Altris AI Standard Functionality for OCT scans interpretation, the first of multiple Altris AI versions, is now approved for commercial sale within the European Union. Altris AI diagnostic software is based on computer ...

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      Mentions: Altris AI Huvitz
    23. Automatic Identification of Diabetic Macular Edema Using a Transfer Learning-Based Approach

      Automatic Identification of Diabetic Macular Edema Using a Transfer Learning-Based Approach

      This paper presents a complete system for the automatic identification of pathological Diabetic Macular Edema (DME) cases using Optical Coherence Tomography (OCT) images as source of information. To do so, the system extracts a set of deep features using a transfer learning-based approach from different fully-connected layers and different pre-trained Convolutional Neural Network (CNN) models. Next, the most relevant subset of deep features is identified using representative feature selection methods. Finally, a machine learning strategy is applied to train and test the potential of the identified deep features in the pathological classification process. Satisfactory results were obtained, demonstrating the suitability ...

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    24. Correspondence: Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Correspondence: Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      We read with interest the article by Mehta and colleagues titled “Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification.” 1 The authors tested 5 methods to binarize optical coherence tomography angiography (OCT-A) en face angiocubes at the superficial capillary plexus (SCP) and choriocapillaris (CC) on a small cohort of healthy subjects. They found significant differences among the methods for the parameters studied, and the differences were more pronounced at the CC level.

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