1. Articles in category: Ophthalmology

    49-72 of 12388 « 1 2 3 4 5 6 ... 515 516 517 »
    1. Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration

      Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration

      Purpose : The purpose of this study was to determine associations between macular drusen parameters derived from an automatic optical coherence tomography (OCT) algorithm, nonadvanced age-related macular degeneration (AMD) stage, and genetic variants. Methods : Eyes classified as early or intermediate AMD with OCT imaging and genetic data were selected ( n = 239 eyes). Drusen area and volume measurements were estimated using the Zeiss Cirrus advanced retinal pigment epithelium analysis algorithm in a perifoveal zone centered on the fovea. Associations between drusen measurements and common genetic variants in the complement and high-density lipoprotein (HDL) lipid pathways and the ARMS2/HTRA1 variant were calculated ...

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    2. Evaluation of retinal nerve fibre layer and ganglion cell complex thickness with optical coherence tomography in migraine patients

      Evaluation of retinal nerve fibre layer and ganglion cell complex thickness with optical coherence tomography in migraine patients

      Aim: In this study, we aimed to assess thicknesses of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with episodic migraine and to compare data between from patients with migraine and healthy individuals. Material and Methods: The study included 44 eyes (right) of 44 patients with migraine who presented to neurology outpatient clinic and 54 eyes (right) of healthy individuals. In patients with migraine (with identified subtypes), demographic and clinical characteristics, Visual Analog Scale (VAS) and Migraine Disability Assessment Scale (MIDAS) results were recorded. After detailed ophthalmological examination, RNFL and GCC thicknesses were measured with optical ...

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    3. Reproducibility of retinal and choroidal measurements using swept-source optical coherence tomography in patients with Parkinson’s disease

      Reproducibility of retinal and choroidal measurements using swept-source optical coherence tomography in patients with Parkinson’s disease

      Purpose: To assess the reproducibility of retinal and choroidal measurements in the macular and peripapillary areas using swept-source optical coherence tomography in patients with Parkinson’s disease. Methods: A total of 63 eyes of 63 patients with idiopathic Parkinson’s disease were evaluated using a three-dimensional protocol of swept-source optical coherence tomography. The following layers were analyzed: full retinal thickness, retinal nerve fiber layer, ganglion cell layer, and choroid. The coefficient of variation was calculated for every measurement. Results: In the macular area, the mean coefficients of variation of retinal thickness, ganglion cell layer + thickness, and choroidal thickness were 0 ...

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    4. Recent advances in anterior chamber angle imaging

      Recent advances in anterior chamber angle imaging

      Differentiating the two main forms of primary glaucoma (open-angle and closed-angle glaucoma) depends on the correct assessment of the anterior chamber angle (ACA). This assessment will determine the management plan and prognosis for the disease. The standard method of examining the angle has been, for many years, slit-lamp gonioscopy. This method, although clinically still useful, is less robust for patient follow up and clinical research, given its low reproducibility. Several imaging technologies have been developed in recent years to improve the evaluation of the ACA and overcome the shortcomings of gonioscopy. These recent advances include three-dimensional and 360° analysis by ...

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    5. Optical Coherence Tomography in a cohort of genetically defined Hereditary Spastic Paraplegia: A brief research report

      Optical Coherence Tomography in a cohort of genetically defined Hereditary Spastic Paraplegia: A brief research report

      Introduction: In-vivo objective documentation of pathological changes in neurodegenerative disease is a major aim to possibly improve our ability to monitor disease progression and response to treatment. Temporal thinning of the retinal nerve fibre layer (RNFL) thickness shown by spectral domain optical coherence tomography (SD-OCT) has been reported in association to the complex forms in hereditary spastic paraplegia (HSP). We performed an assessment of the RNFL thickness in a group of HSP patients, including a longitudinal follow-up in a subgroup. Our aim was to measure and compare the changes and correlate them to clinical progression. Materials & Methods: Twenty-three HSP patients ...

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    6. Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc

      Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc

      Purpose . This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. Methods . In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. The main outcome measures were the retinal nerve fiber layer (RNFL ...

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    7. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGING OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO CHOROIDAL RUPTURE TREATED BY INTRAVITREAL RANIBIZUMAB

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGING OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO CHOROIDAL RUPTURE TREATED BY INTRAVITREAL RANIBIZUMAB

      Purpose: To describe optical coherence tomography angiography findings at baseline and during the follow-up of choroidal neovascularization secondary to choroidal rupture (CR) in a patient with kidney transplant treated by a single intravitreal injection of ranibizumab. Methods: The clinical course, conventional multimodal imaging findings including ultra-widefield fundus color photography and fundus autofluorescence (Optos California, Marlborough, MA), spectral-domain optical coherence tomography (SD-OCT Spectralis; Heidelberg Engineering, Heidelberg, Germany), fluorescein angiography (FA; Heidelberg Engineering, Heidelberg, Germany), indocyanine green angiography ,and optical coherence tomography angiography (Plex-Elite, Carl Zeiss Meditec, Inc, Dublin, CA) findings at baseline and during the follow-up of a patient with choroidal ...

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    8. Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy

      Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy

      Purpose To compare different Swept‐Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy (DR), to find the most suitable slab for grading. Methods Retrospective cross‐sectional study. Consecutive patients with DR were evaluated using SS‐OCTA. The central 12 × 12 mm scan was used to generate the retinal, superficial and deep slab. The grading results of the slabs were then compared to determine if one specific slab is superior to detect respective features. Results A total of 348 eyes (190 patients; mean age 58.1 ± 14.5 years) were graded for features ...

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      Mentions: Sebastian Wolf
    9. Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications

      Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications

      Purpose . The aim of this study was to understand the relationship between the findings of spectral-domain optical coherence tomography (SD-OCT) of previously reported animal models of retinitis pigmentosa (RP) associated with known genetic mutations and their background structural and functional changes. Methods . We reviewed previous publications reporting the SD-OCT findings of animal models of RP and summarized the characteristic findings of SD-OCT in nine different animal models ( RCS –/– , RHO P23H, RHO S334ter, RHO –/– , Rpe65 –/– , rp12, Pde6β –/– (rd1 and rd10), and Arr1 –/– ) of human RP. Results . Despite the various abnormal structural changes found in these different animal models, progressive thinning of ...

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    10. Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage

      Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage

      Purpose To understand the added value of Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements to conventional circumpapillary retinal nerve fibre layer (cpRNFL) thickness measurements on optical coherence tomography (OCT) imaging for discriminating between perimetric glaucoma and healthy eyes, evaluated through a qualitative evaluation. Methods 384 healthy eyes and 188 glaucoma eyes were evaluated, and glaucoma eyes were categorised as perimetric (n=107) based on a history of ≥3 consecutive abnormal 24–2 visual field tests or suspected glaucoma if they did not (n=81). OCT-derived BMO-MRW and cpRNFL reports were qualitatively evaluated by two experienced graders in isolation at ...

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    11. Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

      Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

      récis: Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes. Purpose: To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes. Methods: A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal ...

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    12. Estimation of volumetric optical coherence tomography measurements from 2D color fundus photographs using machine learning

      Estimation of volumetric optical coherence tomography measurements from 2D color fundus photographs using machine learning

      The optic nerve head is the location in the rear of the eye where the nerves exit the eye towards the brain. Swelling of the optic nerve head (ONH) is most accurately quantitatively assessed via volumetric measures using 3D spectral-domain optical coherence tomography (SD-OCT). However, SD-OCT is not always available as its use is primarily limited to specialized eye clinics rather than in primary care or telemedical settings. Thus, there is still a need for severity assessment using more widely available 2D fundus photographs. In this work, we propose machine-learning methods to locally estimate the volumetric measurements (akin to those ...

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    13. ROLE OF ANTERIOR SEGMENT OPTICAL COHERENCE TOPOGRAPHY (AS-OCT) PRE OPERATIVELY TO DETECT PRE-EXISTING WEAKNESS OF POSTERIOR CAPSULE IN PATIENT OF POSTERIOR POLAR CATARACT EFFECTING OUTCOMES DURING PHACOEMULSIFICATION

      ROLE OF ANTERIOR SEGMENT OPTICAL COHERENCE TOPOGRAPHY (AS-OCT) PRE OPERATIVELY TO DETECT PRE-EXISTING WEAKNESS OF POSTERIOR CAPSULE IN PATIENT OF POSTERIOR POLAR CATARACT EFFECTING OUTCOMES DURING PHACOEMULSIFICATION

      Aim: To determine the role of AS-OCT to detect posterior capsular dehiscent preoperative. Design : Prospective hospital based observational study. Material and Method: Patient collection in Government college Kannauj March 2018 to February 2019 .According to Helnsinki’s declaration preoperative assessment and AS-OCT is also performed . Phacoemusification with PCIOL and follow up was done upto 6 week. Result: AS-OCT done for 26 eye out of which in 4 (15.3%) eyes posterior capsule was found dehiscent rest of all eyes posterior capsule was intact. Examination under microscope surgeon found posterior capsular dehiscent only in 3(11.5%).Sensivity of AS-OCT is ...

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    14. Accuracy of Intraocular Lens Refraction Measured by Optical Biometry and Acoustic Biometry in Eyes with Age-Related Macular Degeneration that Underwent Cataract Surgery

      Accuracy of Intraocular Lens Refraction Measured by Optical Biometry and Acoustic Biometry in Eyes with Age-Related Macular Degeneration that Underwent Cataract Surgery

      Purpose: We examined differences between preoperative predicted refractive values and postoperative refractive values calculated by using optical biometry and acoustic biometry for cataract surgery in patients with age-related macular degeneration. Materials and Methods: In this retrospective comparative study, 21 eyes of 18 patients (male, 14 cases; female, four cases; age, 79.2 ± 5.5 years) with age-related macular degeneration and 17 eyes of 17 patients (male, 6 cases; female, 11 cases; age, 75.4 ± 13.2 years) without macular disease that underwent cataract surgery were included. The difference between the preoperative predicted refractive value and postoperative refractive value was examined ...

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    15. The Effect of Gas Tamponade on the Intraocular Lens Position and Refractive Error after Phacovitrectomy: A Swept-source Anterior Segment OCT Analysis

      The Effect of Gas Tamponade on the Intraocular Lens Position and Refractive Error after Phacovitrectomy: A Swept-source Anterior Segment OCT Analysis

      Objective To investigate the intraocular lens position and refractive outcomes following cataract surgery and phacovitrectomy using swept-source anterior segment optical coherence tomography (SS-ASOCT). Design Retrospective case series Subjects Patients underwent cataract surgery (Group A; 34 eyes), phacovitrectomy without gas tamponade (Group B; 20 eyes), and phacovitrectomy with gas tamponade (Group C; 22 eyes). Methods Various parameters associated with the anterior chamber and lens were measured by SS-ASOCT (CASIA2®) before and after surgery. Axial lengths were measured by optical biometry (IOLMaster). The refraction (spherical equivalent) was measured 1 week and 1 month after surgery. Main Outcome Measures Refractive outcomes and the ...

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    16. Reverberant 3D optical coherence elastography maps the elasticity of individual corneal layers

      Reverberant 3D optical coherence elastography maps the elasticity of individual corneal layers

      The elasticity mapping of individual layers in the cornea using non-destructive elastography techniques advances diagnosis and monitoring of ocular diseases and treatments in ophthalmology. However, transient Lamb waves, currently used in most dynamic optical coherence and ultrasound elastography techniques, diminish the translation of wave speed into shear/Young’s modulus. Here, we present reverberant 3D optical coherence elastography (Rev3D-OCE), a novel approach leveraging the physical properties of diffuse fields in detecting elasticity gradients not only in the lateral direction, but also along the depth axis of the cornea. A Monte Carlo analysis, finite element simulations, and experiments in layered phantoms ...

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    17. Optical coherence tomography and neurodegeneration in epilepsy

      Optical coherence tomography and neurodegeneration in epilepsy

      Purpose: To compare optical coherence tomography measurements; central macular thickness, ganglion cell complex, and retinal nerve fiber layer thickness in patients with epilepsy versus healthy controls. Methods: We evaluated 28 eyes of 28 patients with epilepsy and 34 eyes of 34 healthy subjects. Central macular thickness, ganglion cell complex, and retinal nerve fiber layer thickness measurements were performed by spectral-domain optical coherence tomography. Results: Superior and superotemporal quadrant ganglion cell complex, average, and superior quadrant retinal nerve fiber layer thickness measurements were significantly lower in epilepsy group compared to healthy control subjects. Central macular thickness was significantly lower in polytherapy ...

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    18. PERCEPTUAL-ASSISTED ADVERSARIAL ADAPTATION FOR CHOROID SEGMENTATION IN OPTICAL COHERENCE TOMOGRAPHY

      PERCEPTUAL-ASSISTED ADVERSARIAL ADAPTATION FOR CHOROID SEGMENTATION IN OPTICAL COHERENCE TOMOGRAPHY

      Accurate choroid segmentation in optical coherence tomography (OCT) image is vital because the choroid thickness is a major quantitative biomarker of many ocular diseases. Deep learning has shown its superiority in the segmentation of the choroid region but subjects to the performance degeneration caused by the domain discrepancies (e.g., noise level and distribution) among datasets obtained from the OCT devices of different manufacturers. In this paper, we present an unsupervised perceptual-assisted adversarial adaptation (PAAA) framework for efficiently segmenting the choroid area by narrowing the domain discrepancies between different domains. The adversarial adaptation module in the proposed framework encourages the ...

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    19. Characteristics of the Foveal Microvasculature in Asian Patients with Dry Age-Related Macular Degeneration: An Optical Coherence Tomography Angiography Study

      Characteristics of the Foveal Microvasculature in Asian Patients with Dry Age-Related Macular Degeneration: An Optical Coherence Tomography Angiography Study

      Purpose: To evaluate changes in the foveal microvasculature in patients with dry age-related macular degeneration (dry AMD) using optical coherence tomography angiography (OCTA). Methods: Eighty-three eyes with dry AMD and 83 age- and sex-matched normal eyes were enrolled. A 3 × 3 mm 2 OCTA (Zeiss HD-OCT 5000 with AngioPlex; Carl Zeiss Meditec, Dublin, CA, USA) scan was used to acquire images. Vessel density (VD), perfusion density (PD), and the foveal avascular zone (FAZ) of the superficial capillary plexus were analyzed. Results: The VD of the full area, central area, and inner ring of the dry AMD patients (18.61, 8 ...

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    20. Multi-level Dual-attention Based CNN for Macular Optical Coherence Tomography Classification

      Multi-level Dual-attention Based CNN for Macular Optical Coherence Tomography Classification

      In this letter, we propose a multi-level dual-attention model to classify two common macular diseases, age-related macular degeneration (AMD) and diabetic macular edema (DME) from normal macular eye conditions using optical coherence tomography (OCT) imaging technique. Our approach unifies the dual-attention mechanism at multi-levels of the pre-trained deep convolutional neural network (CNN). It provides a focused learning mechanism by taking into account both multi-level features based attention focusing on the salient coarser features and self-attention mechanism attending higher entropy regions of the finer features. Our proposed method enables the network to automatically focus on the relevant parts of the input ...

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    21. Optical coherence tomography (OCT) features of cystoid spaces in choroideremia (CHM)

      Optical coherence tomography (OCT) features of cystoid spaces in choroideremia (CHM)

      Purpose To investigate the prevalence and features of cystoid spaces (CS) in patients with confirmed genetic diagnosis of choroideremia (CHM) using swept source optical coherence tomography (OCT). Methods We retrospectively reviewed CHM patients examined at the Regional Reference Center for Hereditary Retinal Degenerations at the Eye Clinic in Florence. We took into consideration genetically confirmed CHM patients with ophthalmological and swept source optical coherence tomography (OCT) examinations. The presence/absence and location of cystoid spaces in the retina of each eye were reported. Results A total of 42 eyes of 21 CHM patients were included in our series. The average ...

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    22. ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION Comparison Between Optical Coherence Tomography Angiography and Dye Angiography

      ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION Comparison Between Optical Coherence Tomography Angiography and Dye Angiography

      Purpose: This study aims to suggest a novel strategy for assessing the activity of myopic choroidal neovascularization ( mCNV ) based on optical coherence tomography angiography ( OCTA ) and to compare it with traditional fundus fluorescein angiography as the gold standard. Methods: Macular OCTA images were obtained using RTVue XR Avanti with AngioVue. Morphologic features of mCNV lesions were analyzed. Characteristics of OCTA in 41 eyes with active mCNV and 41 eyes with inactive mCNV were analyzed. Optical coherence tomography angiography parameters associated with mCNV activity and the clinical significance of their sensitivity and specificity were analyzed using fundus fluorescein angiography as the ...

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    23. Analysis of Hyperreflective Dots Within the Central Fovea in Healthy Eyes Using En Face Optical Coherence Tomography

      Analysis of Hyperreflective Dots Within the Central Fovea in Healthy Eyes Using En Face Optical Coherence Tomography

      Purpose : The purpose of this retrospective study was to describe and quantify superficial hyperreflective dots within the central fovea and correlate them with age, using en face and cross-sectional B-scan optical coherence tomography (OCT). Methods : Healthy eyes, evaluated with a spectral domain instrument (primary cohort) at the Stein Eye Institute (UCLA) and with a swept source instrument (secondary cohort) at the Vitreous Retina Macula Consultants of New York, were included in this study. En face OCT images (3 × 3 mm) segmented at the level of the superior vascular plexus were acquired, and hyperreflective dots in the foveal avascular zone were ...

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    24. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DETECTS SUBCLINICAL RADIAL PERIPAPILLARY CAPILLARY DENSITY REDUCTION AFTER PLAQUE RADIOTHERAPY FOR CHOROIDAL MELANOMA

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DETECTS SUBCLINICAL RADIAL PERIPAPILLARY CAPILLARY DENSITY REDUCTION AFTER PLAQUE RADIOTHERAPY FOR CHOROIDAL MELANOMA

      Purpose: To evaluate radial peripapillary capillary density (RPCD) in irradiated eyes without radiation papillopathy clinically. Methods: Patients treated with plaque radiotherapy for unilateral choroidal melanoma without radiation papillopathy clinically received optical coherence tomography and optical coherence tomography angiography imaging at ∼12- to 24-month follow-up. Comparison of RPCD globally and meridian closest to plaque and meridian farthest to plaque of irradiated versus nonirradiated eyes was performed. Results: Mean age was 55 years (n = 10). Mean largest basal diameter and thickness were 10.1 and 4.4 mm, respectively. Mean radiation dose to the optic nerve head and foveola was 41.7 ...

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