1. Articles in category: Ophthalmology

    49-72 of 11652 « 1 2 3 4 5 6 ... 484 485 486 »
    1. Analysis of new attachment site in medial rectus resection with advancement using anterior segment optical coherence tomography

      Analysis of new attachment site in medial rectus resection with advancement using anterior segment optical coherence tomography

      Objective To evaluate the surgical outcome of unilateral medial rectus resection with small advancement for recurrent exotropia , ≤30 prism diopters (PD), and verify new attachment site anatomically using anterior segment optical coherence tomography (ASOCT). Method This study is a retrospective chart review of patients who underwent 1.0mm advancement of unilateral resected medial rectus from original medial rectus (OMR) insertion for recurrent exotropia since 2014. The age at operation, sex, preoperative angle of deviation, near stereopsis , and suppression were evaluated. Success was defined as ≤5 PD of esodeviation or ≤10 PD of exodeviation at the final visit. Preoperative scleral thickness ...

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      Mentions: Korea University
    2. Application of optical coherence tomography angiography in diabetic retinopathy: a comprehensive review

      Application of optical coherence tomography angiography in diabetic retinopathy: a comprehensive review

      Optical coherence tomography angiography (OCTA) is a noninvasive method that enables visualization of blood flow within retinal vessels down to the size of capillaries by detecting motion contrast from moving blood cells. OCTA provides a fast and safe procedure to assess retinal microvasculature with higher contrast and resolution than conventional fluorescence angiography . The different capillary plexuses are displayed separately and their perfusion density can be quantified. Imaging capabilities such as these have led to an emerging field of clinical application for OCTA in vascular diseases such as diabetic retinopathy (DR). Evaluation of parameters such as parafoveal capillary perfusion density could ...

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    3. Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension

      Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension

      We investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations with systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) with quantitative microvascular analysis of the choriocapillaris was performed. Linear regression was used to ...

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    4. Swept-Source Optical Coherence Tomography Angiography of Retinal Arterial Macroaneurysm With Overlying Hemorrhage

      Swept-Source Optical Coherence Tomography Angiography of Retinal Arterial Macroaneurysm With Overlying Hemorrhage

      A patient in their 90s with hypertension and diabetes type 2 noted the sudden onset of decreased visual acuity of 20/70 OS due to a subinternal limiting membrane macular hemorrhage. Blood obscured the view posteriorly, evidenced by blocked fluorescence exceeding 5 minutes on fluorescein angiography ( Figure , A). Swept-source optical coherence tomography angiography (SS-OCTA) demonstrated a retinal arterial macroaneurysm ( Figure , B). The SS-OCTA uses scatter from high-speed acquisition (100 000 A-scans/s) with a long center wavelength (1040-1060 nm), 1 allowing for deep penetration of light through retinal tissue and, in this case, hemorrhage. Although indocyanine green angiography can be ...

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    5. Widefield OCT angiography and ultra-widefield multimodal imaging of Susac syndrome

      Widefield OCT angiography and ultra-widefield multimodal imaging of Susac syndrome

      The aim is to present the changes in ultra-widefield and widefield multimodal imaging, including optical coherence tomography angiography of a 33-year-old woman diagnosed with Susac syndrome, over 1 year of follow-up. Fundus examination and multimodal imaging revealed bilateral arterial occlusion of multiple vascular branches with retinal ischemia. Over 1 year follow-up, best-corrected visual acuity improved while retinal ischemia gradually resolved. Widefield optical coherence tomography angiography showed reperfusion of macular large vessels, but not of the small capillaries. Despite anatomical improvement, functional defects of the visual field persisted. In conclusion, widefield and ultra-widefield imaging provided high-resolution details of the central and ...

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    6. Defining Disease Activity in Neovascular AMD With Optical Coherence Tomography Angiography

      Defining Disease Activity in Neovascular AMD With Optical Coherence Tomography Angiography

      The purpose of this study is to be able to describe optical coherence angiography (OCTA) patterns of disease activity and quiescence in eyes that have received treatment. Our target population group is patients that have neovascular age-related macular degeneration and have had treatment with aflibercept for this condition. This is a single-site study and does not involve any masking or treatment allocation.

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    7. Optical coherence tomography angiography of types 1 and 2 choroidal neovascularization in age-related macular degeneration during anti-VEGF therapy: evaluation of a new quantitative method

      Optical coherence tomography angiography of types 1 and 2 choroidal neovascularization in age-related macular degeneration during anti-VEGF therapy: evaluation of a new quantitative method

      Purpose The aim of this pilot study was to test whether mathematical parameters of the vascular morphology of choroidal neovascularization (CNV) can be used as biomarkers and to investigate how these parameters change during anti-vascular endothelial growth factor (VEGF) therapy. Methods Treatment-naive CNV in exudative age-related macular degeneration (AMD) was diagnosed in 28 patients. OCT-angiography (OCT-A) (Avanti/FA Optovue) performed before and after anti-VEGF therapy. The OCT-A data sets were exported to an external image processing program and vessel skeletonization was accomplished by means of edge detection. Based on this technique the total vessel length, the number of segments and ...

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      Mentions: Optovue
    8. Test performance of optical coherence tomography angiography in detecting retinal diseases: a systematic review and meta-analysis

      Test performance of optical coherence tomography angiography in detecting retinal diseases: a systematic review and meta-analysis

      Objective To investigate the diagnostic accuracy of optical coherence tomography angiography (OCTA) in detecting vascular characteristics of chorio-retinal disease. Methods Evidence acquisition: We searched Web of Science, Scopus, and Medline by the citation of references and complemented these electronic searches by checking the list of references of included and review articles. Screening, selection, assessment, and extraction was performed in parallel by two authors. Results Evidence synthesis: Systematic review and exploratory meta-analysis. The ten studies that contributed to the meta-analysis enrolled 440 eyes and allowed constructing ten two-by-two tables. The tables reported on detection of choroidal neovascularization (CNV) in eyes suffering ...

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      Mentions: Pearse A. Keane
    9. Exploring the association of collaterals and vessel density using optical coherence tomography angiography in retinal vein occlusions

      Exploring the association of collaterals and vessel density using optical coherence tomography angiography in retinal vein occlusions

      Purpose: Using optical coherence tomography angiography (OCTA) to characterize the types of collaterals in eyes with retinal vein occlusion (RVO) and further investigate their correlations with vessel densities of the superficial (SCP) and the deep capillary plexus (DCP). Methods: This cross-sectional study included 25 eyes of 23 patients with RVO. 3 x 3 mm2 OCTA macular scans were used to quantify the parafoveal vessel density (VD) of the SCP and DCP, and to classify the collaterals into one of four types (true superficial, true deep, superficial diving, and foveal collateral). Poisson regression model was used to identify significant associations between ...

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    10. Comparison of wide field optical coherence tomography angiography with extended field imaging and fluorescein angiography in retinal vascular disorders

      Comparison of wide field optical coherence tomography angiography with extended field imaging and fluorescein angiography in retinal vascular disorders

      Purpose To compare swept source OCTA device, with and without the extended field imaging (EFI) technique, to standard fluorescein angiography (FA) in the clinical practice. Methods Consecutive patients with vascular disorder patients underwent FA with 55-degree lens (Spectralis Heidelberg Engineering, Heidelberg, Germany) and OCTA with the prototype PlexElite (Carl Zeiss Meditec, Dublin, CA) using a 12 mm x 12 mm volume scan pattern centered on the fovea and a prototype of + 20.00-diopter designed specifically by Zeiss. The imaging methods were compared for visible field of view, extension of non-perfused areas, presence and number of neovessels, vessel density (VD) and ...

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    11. An overview of optical coherence tomography angiography and the posterior pole

      An overview of optical coherence tomography angiography and the posterior pole

      Optical coherence tomography angiography is a relatively new, noninvasive technology that has revolutionized imaging of the retinal and choroidal microvasculature. This technology is based on the detection of movement or changes that represent moving red cells in sequential optical coherence tomography scans. As with other established imaging technologies, it has unique benefits as well as certain disadvantages, which include a limited field of view and vulnerability to imaging artifacts. However, software and hardware improvements are continually evolving to mitigate these limitations. Optical coherence tomography angiography has been used to gain a better understanding of microvascular changes across a spectrum of ...

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    12. Optical Coherence Tomography Angiographic Findings of Tamoxifen Retinopathy: Similarity with Macular Telangiectasia Type 2

      Optical Coherence Tomography Angiographic Findings of Tamoxifen Retinopathy: Similarity with Macular Telangiectasia Type 2

      Purpose We aimed to describe the vascular changes in eyes associated with tamoxifen retinopathy using optical coherence tomography angiography (OCTA) and to compare these changes with abnormalities in macular telangiectasia type 2 (MacTel2) previously reported in the literature. Design Retrospective, observational study Participants Seventeen eyes with tamoxifen retinopathy and 17 eyes of age-matched normal controls. Methods The medical records of patients who visited the ophthalmology department with a history of taking tamoxifen were reviewed. Tamoxifen retinopathy was diagnosed based on typical spectral domain-optical coherence tomography (SD-OCT) findings, such as intraretinal cavitation and/or photoreceptor disruption. Multimodal imaging, particularly focused on ...

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    13. Glaucoma progression analysis by Spectral-Domain Optical Coherence Tomography (SD-OCT)

      Glaucoma progression analysis by Spectral-Domain Optical Coherence Tomography (SD-OCT)

      Spectral domain optical coherence tomography (SD-OCT) provides an objective quantification of the lesions of various target tissue structures in glaucoma, with unprecedented resolution, which has now demonstrated its interest in controlling the progression of glaucomatous neuropathy , from early stages to late stages. A certain number of well-established proofs state that a progressive modification in OCT is a common predictor of functional loss, and that patients with rapid OCT changes have an increased risk of developing glaucomatous scotoma . Follow-up of the progression goes through three stages. It consists first of all in detecting the evolution of damage to the retinal nerve ...

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    14. Anterior Segment Parameters of Filipino-Americans Compared to Chinese-Americans and Caucasian Americans Using Anterior Segment Optical Coherence Tomography

      Anterior Segment Parameters of Filipino-Americans Compared to Chinese-Americans and Caucasian Americans Using Anterior Segment Optical Coherence Tomography

      Purpose : We compare anterior segment characteristics of Filipino- versus Chinese- and Caucasian-Americans to describe the differences in risk factors among each ethnic group. Methods : A cross-sectional study was conducted among Filipino, Chinese, and Caucasian subjects without glaucoma who underwent a standardized set of ocular examinations and anterior segment optical coherence tomography (Visante ASOCT) imaging. Zhongshan Angle Assessment Program (ZAAP) 4 was used for ASOCT image analysis. The following quantitative parameters wereobtained from ZAAP: (1) angle opening distance (AOD500, AOD750), angle recess area at 750 μm (ARA), and trabecular-iris space area at 500 and 750 μm (TISA500, TISA750); (2) iris parameters ...

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    15. Optical Coherence Tomography Angiography Quantitative Assessment of Exercise-Induced Variations in Retinal Vascular Plexa of Healthy Subjects

      Optical Coherence Tomography Angiography Quantitative Assessment of Exercise-Induced Variations in Retinal Vascular Plexa of Healthy Subjects

      Purpose : To assess the variations induced by exercise in retinal vascular density (VD), foveal avascular zone (FAZ) area, and fractal dimension (FD) at the superficial (SCP) and deep (DCP) capillary plexa in healthy subjects by means of optical coherence tomography angiography (OCT-A). Methods : Consecutive healthy subjects were prospectively included into two groups, ranging in age from 18 to 29 years for group 1 and from 30 to 40 years for group 2. Data from 3 × 3-mm OCT-A acquisition centered on the macula at SCP and DCP (VD, FAZ area, and FD), heart rate, and systolic-diastolic blood pressure were collected before ...

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    16. Discordance of Disc-Fovea Raphe Angles Determined by Optical Coherence Tomography and MP-3 Microperimetry in Eyes With a Glaucomatous Hemifield Defect

      Discordance of Disc-Fovea Raphe Angles Determined by Optical Coherence Tomography and MP-3 Microperimetry in Eyes With a Glaucomatous Hemifield Defect

      Purpose : The purpose of this study was to evaluate the concordance of a temporal raphe architecture estimated using optical coherence tomography (OCT) and MP-3 microperimetry. Methods : We enrolled 25 eyes with either an upper or lower glaucomatous hemifield defect, as detected on the Humphrey visual field 30-2 test. A structural temporal raphe was extrapolated from visible end points of retinal nerve fiber bundles present in a perimetrically normal hemiretina on an en face Spectralis OCT image. A functional temporal raphe was drawn as a line from the fovea to the border of at least a 10-dB difference in sensitivity, at ...

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    17. Cluster analysis of computerized visual field and optical coherence tomography–ganglion cell complex defects in high intraocular pressure patients or early stage glaucoma

      Cluster analysis of computerized visual field and optical coherence tomography–ganglion cell complex defects in high intraocular pressure patients or early stage glaucoma

      Purpose: The aim of the study is to evaluate the relationship between functional defects shown by cluster analysis of computerized visual field and anatomic defects from optical coherence tomography–ganglion cell complex examination in ocular hypertension or eyes affected by glaucoma. Methods: 205 eyes affected by ocular hypertension (intraocular pressure > 22 mmHg) or early stage glaucoma were enrolled. The age of the patients ranged from 26 to 87 years (average: 61.83 ± 1.54 years). Computerized 30° visual field (Octopus G1x Dynamic strategy) and optical coherence tomography–ganglion cell complex (I-Vue Optovue) analyses were performed for each eye selected; 68 ...

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    18. Swept-Source Optical Coherence Tomography for Evaluating the Lamina Cribrosa A Report by the American Academy of Ophthalmology

      Swept-Source Optical Coherence Tomography for Evaluating the Lamina Cribrosa A Report by the American Academy of Ophthalmology

      Objective To review the published literature on the use of swept-source optical coherence tomography (SS-OCT) for evaluating the lamina cribrosa in glaucoma. Methods A PubMed and Cochrane Library literature search initially conducted on March 3, 2017 and updated on June 26, 2018 yielded a total of 64 articles. Articles that were reviews or that were not published in English were excluded, and 29 were found to fit the inclusion criteria. The panel methodologist then assigned a level of evidence rating to each study. Fifteen studies were rated level III, 14 studies were rated level II, and no studies were rated ...

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    19. Optical Coherence Tomography Angiography and Glaucoma: A Brief Review

      Optical Coherence Tomography Angiography and Glaucoma: A Brief Review

      Optical coherence tomography angiography (OCTA) is a new modality in ocular imaging which provides non-invasive assessment and measurement of the vascular structures in the retina and optic nerve head. This technique provides useful information in glaucoma, such as quantitative assessment of vessel density. Vessel density measurement can be affected by various subject-related, eye-related, and diseaserelated factors. Overall, OCTA has good repeatability and reproducibility, and can differentiate glaucoma eyes from normal eyes. It can also help detect early glaucoma, reach a floor effect at a more advanced disease stage than optical coherence tomography (OCT), and adds information about glaucoma patients at ...

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    20. University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives a 2019 NIH Grant for $381,250 for Choroidal Disease Mechanisms in AMD. The principal investigator is Elliott Sohn. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. We propose to investigate the pathophysiology of choroidal degeneration in age-related macular degeneration (AMD), the most common form of untreatable central vision loss in the western world. The choroid, the complex vascular system supplying the outer retina, photoreceptors, and retinal pigment epithelium (RPE), can now be visualized in living humans using enhanced depth imaging optical coherence tomography (OCT). Recent studies ...

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    21. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives NIH Grant  for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives a 2019 NIH Grant for $39,955 for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography. The principal investigator is Brian Soetikno. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The retina is one of the most metabolically active tissues in the human body, making it particularly susceptible to hypoxia. In diabetic retinopathy (DR), aberrant oxygen metabolism has been hypothesized to play a pivotal role its pathogenesis. An improved understanding of how imbalances in oxygen delivery and demand lead to the progression of DR ...

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    22. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives a 2019 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dyanamics. The principal investigator is Sueng Shen. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not ...

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    23. Indiana University Receives NIH Grant for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells

      Indiana University Receives NIH Grant for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells

      Indiana University Receives a 2019 NIH Grant for $452,718 for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells. The principal investigator is Donald Miller. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Ganglion cells (GCs) and other inner retinal neurons are fundamental to retinal neural circuitry, processing photoreceptor signals relayed from intermediate neurons for transmission to the brain. Yet, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. GCs in particular are lost to neurodegenerative disorders such as glaucoma, Alzheimer’s disease ...

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    24. University of Alabama at Birmingham Receives NIH Grant for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression

      University of Alabama at Birmingham Receives NIH Grant for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $635,960 for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression. The principal investigator is Massimo Fazio. The program began in 2017 and ends in 2021. Below is a summary of the proposed work. This proposal is focused on morphological changes in the lamina cribrosa with glaucoma onset and progression, and how those changes impact visual function, with a focus on racial disparities. This project leverages on the longitudinal monitoring of a subset of glaucoma patients in the existing ADAGES cohort of which ...

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