1. Articles in category: Ophthalmology

    49-72 of 11162 « 1 2 3 4 5 6 ... 463 464 465 »
    1. Efficacy of intravitreal aflibercept monotherapy in retinopathy of prematurity evaluated by periodic fluorescence angiography and optical coherence tomography

      Efficacy of intravitreal aflibercept monotherapy in retinopathy of prematurity evaluated by periodic fluorescence angiography and optical coherence tomography

      Purpose To evaluate the efficacy of intravitreal aflibercept (IVA) in vascular and macular maturation in neonates with type 1 retinopathy of prematurity (ROP) and aggressive posterior retinopathy of prematurity (APROP). Materials and methods Thirty-six eyes of 18 patients with type 1 ROP or APROP in zone I or posterior zone II were enrolled in our study. At baseline, only fluorescein angiography (FA) was performed. After IVA injection, both FA and optical coherence tomography (OCT) were performed after 6.8 ± 0.8 (range 6–8) and 19 ± 0.9 (range 18–20) weeks to follow vascular and macular changes. Results Both ...

      Read Full Article
    2. Three-dimensional Optical Coherence Tomography Image Denoising via Multi-input Fully-Convolutional Networks

      Three-dimensional Optical Coherence Tomography Image Denoising via Multi-input Fully-Convolutional Networks

      — In recent years, there has been a growing interest in applying convolutional neural networks (CNNs) to low-level vision tasks such as denoising and super-resolution. Optical coherence tomography (OCT) images are inevitably affected by noise, due to the coherent nature of the image formation process. In this paper, we take advantage of the progress in deep learning methods and propose a new method termed multi-input fully-convolutional networks (MIFCN) for denoising of OCT images. Despite recently proposed natural image denoising CNNs, our proposed architecture allows exploiting high degrees of correlation and complementary information among neighboring OCT images through pixel by pixel fusion ...

      Read Full Article
    3. Novel application of anterior segment optical coherence tomography for periocular imaging

      Novel application of anterior segment optical coherence tomography for periocular imaging

      Objective This study aims to assess the use of optical coherence tomography (OCT) imaging for periocular skin lesions and to determine which characteristic features of these images can be correlated to histopathology . Design This is an ongoing prospective study with Research Ethics Board approval. Participants Fifty patients over 18 years old with lesions clinically suspicious of nonmelanoma skin cancer on the periocular region were included in this study. Methods After consent was obtained, clinical photographs and dermatoscopic images were obtained (DermLite II Hybrid M) from the lesion and its contralateral side. Subsequently, the patient was subjected to OCT imaging using ...

      Read Full Article
    4. Choroidal thickness in preeclampsia measured by spectral-domain optical coherence tomography

      Choroidal thickness in preeclampsia measured by spectral-domain optical coherence tomography

      Purpose To compare choroidal thickness (CT) measurements in preeclamptic and healthy women in the third trimester of pregnancy using optical coherence tomography. Methods This cross-sectional study included 148 eyes of 74 women, divided into two groups: 27 healthy pregnant women in the third trimester (control group) and 47 age-matched pregnant women in the third trimester with preeclampsia (PE group). Of the 47 subjects in preeclampsia group, 26 were classified as having mild PE and 21 as having severe PE. Choroidal thickness was measured at ten different locations: at the fovea and every 500 µm from the fovea up to 2500 ...

      Read Full Article
    5. Functional optical coherence tomography of retinal photoreceptors

      Functional optical coherence tomography of retinal photoreceptors

      Age-related macular degeneration (AMD) is the leading cause of severe vision loss and legal blindness. It is known that retinal photoreceptors are the primary target of AMD. Therefore, a reliable method for objective assessment of photoreceptor function is needed for early detection and reliable treatment evaluation of AMD and other eye diseases such as retinitis pigmentosa that are known to cause photoreceptor dysfunctions. Stimulus-evoked intrinsic optical signal (IOS) changes promise a unique opportunity for objective assessment of physiological function of retinal photoreceptor and inner neurons. Instead of a comprehensive review, this mini-review is to provide a brief summary of our ...

      Read Full Article
      Mentions: Xincheng Yao
    6. OCT Angiography: A Technique for the Assessment of Retinal and Optic Nerve Diseases in the Pediatric Population

      OCT Angiography: A Technique for the Assessment of Retinal and Optic Nerve Diseases in the Pediatric Population

      Optical coherence tomography angiography (OCT-A) is a novel, rapidly evolving, non-invasive imaging technique that allows images of the retinal vasculature to be obtained in a few seconds. Blood vessels of different retinal vascular plexuses and the foveal avascular zone (FAZ) can be examined without the administration of any contrast or dye. Due to these characteristics, OCT-A could be an excellent complementary test to study retinal vascularization in children. Until now, most of the studies with OCT-A have been conducted in adults and only a few have been carried out in children. In this review, we describe the principles and advantages ...

      Read Full Article
    7. Assessment of Visual Function With a Portable Brain-computer Interface

      Assessment of Visual Function With a Portable Brain-computer Interface

      ief Summary: The purpose of this study is to evaluate the nGoggle's accuracy and repeatability in detecting visual function loss. In addition, the ability to stage glaucomatous damage and investigate the relationship between nGoggle metrics and neural damage in glaucoma will also be evaluated. Longitudinal study, including 200 patients with: glaucoma, suspected of having glaucoma, nonglaucomatous optic neuropathies, AMD, retinal degenerations, other diseases involving the visual pathways, besides healthy controls. Subjects will perform standard ophthalmological exams, and the following research tests: electroencephalogram, visual evoked potentials, and questionnaires. Statistical analyses will be performed by the PI using the software Stata ...

      Read Full Article
    8. Retinal nerve fiber layer analysis in cocaine users

      Retinal nerve fiber layer analysis in cocaine users

      Cocaine is a well-known factor of tissue ischemia and may be related to thinning of the inner retinal layers. The present study aimed to evaluate and determine whether cocaine users show retinal nerve fiber layer (RNFL) thinning by means of spectral-domain optical coherence tomography. A group of 17 cocaine users and 18 non-users were recruited for complete ophthalmologic examination. Spectral domain optical coherence tomography (Cirrus OCT) was used to evaluate peripapillary RNFL and macular thickness. The average RNFL measurement in the cocaine users group was significantly thinner compared to the control group. Subjects in the cocaine users group showed significant ...

      Read Full Article
    9. Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography

      Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography

      Purpose: To evaluate the incidence of clinical and subclinical cystoid macular edema in diabetic and non-diabetic patients after cataract surgery by means of Optical Coherence Tomography (OCT). Materials & Methods: A total of 30 eyes of 30 patients (15 diabetic and 15 non-diabetic) aged between 50 and 80 years diagnosed to have cataract were enrolled. Patients were investigated for absence of any evidence of macular edema with OCT before surgery. After undergoing cataract extraction by phacoemulsification with foldable IOL implant, OCT was again carried out at post operative 1st week and 4th week to know the foveal thickness and total macular ...

      Read Full Article
    10. Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling

      Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling

      Objective To compare thickness and reflectance of retinal layer findings in patients with idiopathic epiretinal membranes (ERMs), before and after surgery, to normal controls. Design A retrospective study Subjects Patients with ERMs before and after surgery and normal controls. Methods Spectral domain optical coherence tomography (SD-OCT) of eyes with ERMs, before and after surgery, and normal eyes were analyzed for morphologic appearance and using a customized algorithm to measure retinal layer reflectance and thickness. Findings were correlated with visual acuity outcomes. Main Outcome Measure Retinal layer thickness and reflectance Results Thirty-four ERM and 12 normal eyes were identified. Mean preoperative ...

      Read Full Article
    11. Cost-effectiveness of digital surveillance clinics with optical coherence tomography versus hospital eye service follow-up for patients with screen-positive maculopathy

      Cost-effectiveness of digital surveillance clinics with optical coherence tomography versus hospital eye service follow-up for patients with screen-positive maculopathy

      Background Annually 2.7 million individuals are offered screening for diabetic retinopathy (DR) in England. Spectral-Domain Optical Coherence Tomography (SD-OCT) has the potential to relieve pressure on NHS services by correctly identifying patients who are screen positive for maculopathy on two-dimensional photography without evidence of clinically significant macular oedema (CSMO), limiting the number of referrals to hospitals. We aim to assess whether the addition of SDOCT imaging in digital surveillance clinics is a cost-effective intervention relative to hospital eye service (HES) follow-up. Methods We used patient-level data from the Gloucestershire Diabetic Eye Screening Service linked to the local digital surveillance ...

      Read Full Article
    12. 250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea

      250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea

      We present the first spectral domain optical coherence tomography (SD-OCT) system that combines an isotropic imaging resolution of ~1.5 µm in biological tissue with a 250 kHz image acquisition rate, for in vivo non-contact, volumetric imaging of the cellular structure of the human cornea. OCT images of the healthy human cornea acquired with this system reveal the cellular structure of the corneal epithelium, cellular debris and mucin clusters in the tear film, the shape, size and spatial distribution of the sub-basal corneal nerves and keratocytes in the corneal stroma, as well as reflections from endothelial nuclei. The corneal images ...

      Read Full Article
    13. Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

      Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

      Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure–function map. In this review, the structure–function mapping methods in clinical use are discussed. Typical clinical maps provide a population average, ‘one size fits all’ representation, but in recent years methods for customising structure–function maps to individual eyes have been developed and these are reviewed here. In ...

      Read Full Article
    14. Optical coherence tomography is a useful tool in the differentiation between true edema and pseudoedema of the optic disc

      Optical coherence tomography is a useful tool in the differentiation between true edema and pseudoedema of the optic disc

      Purpose To assess the usefulness of spectral-domain optical coherence tomography (SD-OCT) peripapillary retinal nerve fiber layer (RNFL) thickness measurement in discriminating early phase optic disc edema (ODE) from pseudoedema (PODE). Methods Hospital-based, multicenter, cross-sectional study involving external patients referred for recent identification of “presumed ODE”. Patients underwent SD-OCT optic nerve head (ONH) RNFL thickness measurement at their first evaluation. In 155 of these, the causative etiology was subsequently ascertained and the respective eyes (one per patient) were assigned to the ODE (95 eyes) or PODE (60 eyes) group. Admission SD-OCT data were retrieved and used for the analysis. ROC curve ...

      Read Full Article
    15. CLARITY Imaging Study

      CLARITY Imaging Study

      OCT image quality is necessary to provide accurate diagnostic information to ophthalmologists. The increasing resolution of imaging techniques will require ever more high standards of optical transmission through the cornea and tear film. Given that lubricant drops can improve optical transmission through the cornea, this study will attempt to quantify this. The primary objective is to assess the effect of cross-linked sodium hyaluronate on OCT image quality compared to the effect of blinking alone.

      Read Full Article
    16. Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging

      Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging

      In super-continuum (SC) source based spectral domain optical coherence tomography (SC-SDOCT), the stability of the power spectral density (PSD) has a significant impact on OCT system sensitivity and image signal to noise ratio (SNR). High speed imaging decreases the camera's exposure time, thus each A-scan contained fewer laser pulse excited SC wideband emissions, resulting in a decrease of SNR. In this manuscript, we present a buffer-averaging SC-SDOCT (BASC-SDOCT) to improve the system's performance without losing imaging speed, taking advantage of the excess output power from typical SC sources. In our proposed technique, the output light from SC was ...

      Read Full Article
    17. Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study

      Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study

      Objective To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. Design Retrospective, cross-sectional study. Methods A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2). Macular 3 × 3 mm angiography was acquired using the Zeiss Cirrus 5000 OCT instrument. Vessel density (VD), perfusion density (PD), and foveal avascular zone ...

      Read Full Article
    18. Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Purpose To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting. Design Reliability analysis. Methods A total of 2027 phakic subjects aged ≥50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy was performed by a single trained ophthalmologist. SS-OCT angle scans, which obtain radial scans for the entire circumference of the angle, were analyzed by a single examiner, masked to the subject’s ...

      Read Full Article
    19. Collateral vessels on optical coherence tomography angiography in eyes with branch retinal vein occlusion

      Collateral vessels on optical coherence tomography angiography in eyes with branch retinal vein occlusion

      Aims To detect collateral vessels using optical coherence tomography angiography (OCTA) in eyes with branch retinal vein occlusion (BRVO) and to investigate the associations with visual outcomes and macular oedema. Methods Eyes with macular oedema secondary to BRVO that underwent OCTA at baseline and were followed up for more than 6 months were enrolled. The presence of collaterals, whether the collaterals were leaky or not, and the associations with visual outcomes and macular oedema were investigated. Results Twenty-eight eyes of 28 patients (8 men and 20 women; mean age, 68 years) were enrolled. Collaterals were detected in 23 eyes (82 ...

      Read Full Article
    20. Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease

      Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease

      Importance Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. Objective To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic findings in Coats disease. Design, Setting, and Participants This retrospective cohort study was conducted in a single tertiary institution (Duke Eye Center) and identified 28 children with Coats disease through a review of medical records from December 2002 to January 2018. Four eyes were obtained from a biorepository for histopathologic analysis. Main Outcomes and Measures Macular OCT, fundus photographs, and FA results were reviewed and compared for morphological changes ...

      Read Full Article
    21. Evaluation of Ocular Complications By Using Optical Coherence Tomography in Children with Sickle Cell Disease

      Evaluation of Ocular Complications By Using Optical Coherence Tomography in Children with Sickle Cell Disease

      Purpose: This study was aimed to evaluate ocular abnormalities by using optical coherence tomography (OCT) in children with sickle cell disease (SCD) and to search the relationship between OCT and clinical findings. Methods: The study included 108 eyes of 54 SCD patients as well as 110 eyes of 55 healthy subjects with no ocular pathology as a control group. A complete ophthalmologic examination was performed. Pupillary dilation was induced and macular sections were obtained with spectral domain OCT. Macular sections were evaluated according to the ETDRS map. Inner and outer retinal thicknesses were measured using the software in the device ...

      Read Full Article
    22. Optical coherence tomography angiography in exudative age-related macular degeneration: a predictive model for treatment decisions

      Optical coherence tomography angiography in exudative age-related macular degeneration: a predictive model for treatment decisions

      Aims To evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity. Methods Retrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo. These findings were then correlated with those of structural OCT scans. A ...

      Read Full Article
    49-72 of 11162 « 1 2 3 4 5 6 ... 463 464 465 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (4 articles) Johns Hopkins University
    2. (4 articles) Duke University
    3. (3 articles) Medical University of Vienna
    4. (3 articles) University of Miami
    5. (2 articles) Universidade Federal de São Paulo
    6. (2 articles) Nagoya University
    7. (2 articles) UCLA
    8. (2 articles) University of Michigan
    9. (2 articles) University of Toronto
    10. (2 articles) University of Waterloo
    11. (2 articles) Singapore Eye Research Institute
    12. (2 articles) University of Rochester
  4. People in the News

    1. (1 articles) Vishali Gupta
    2. (1 articles) Cynthia A. Toth
    3. (1 articles) Sotaro Ooto
    4. (1 articles) Eric H. Souied
    5. (1 articles) Rohit Varma
    6. (1 articles) Michael Pircher
    7. (1 articles) David S. Friedman
    8. (1 articles) William J. Feuer
    9. (1 articles) Christoph K. Hitzenberger
    10. (1 articles) Akitaka Tsujikawa
    11. (1 articles) Robert N. Weinreb
    12. (1 articles) Eric A. Swanson
  5. OCT Companies in the News

    1. (7 articles) Carl Zeiss Meditec
    2. (5 articles) Optovue
    3. (2 articles) Tomey Corporation
    4. (2 articles) Heidelberg Engineering
    5. (1 articles) Topcon Medical Systems
    6. (1 articles) Nidek
    7. (1 articles) Notal Vision
    8. (1 articles) Bioptigen