1. Articles in category: Ophthalmology

    553-576 of 5888 « 1 2 ... 21 22 23 24 25 26 27 ... 244 245 246 »
    1. Correlation between retinal vessel density profile and circumpapillary RNFL thickness measured with Fourier-domain optical coherence tomography

      Correlation between retinal vessel density profile and circumpapillary RNFL thickness measured with Fourier-domain optical coherence tomography

      Aim To assess circumpapillary retinal vessel density (RVD) profiles and correlate them with retinal nerve fibre layer (RNFL) thickness measured by Fourier domain optical coherence tomography (FD-OCT). Methods RNFL thickness of 106 healthy volunteers was measured using Cirrus FD-OCT. A proprietary software was developed in MATLAB to assess the thickness and position of circumpapillary retinal vessels using the scanning laser ophthalmoscopy fundus image, centred on the optic disc. The individual retinal vessel positions and thickness values were integrated in a 256-sector RVD profile, and intrasubject and intersubject correlations were calculated. Results The mean value±SD for intrasubject correlation between RVD ...

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    2. Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial

      Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial

      Purpose: To determine the impact of segmentation error correction and precision of standardized grading of time domain optical coherence tomography (OCT) scans obtained during an interventional study for macular edema secondary to central retinal vein occlusion (CRVO). Methods: A reading center team of two readers and a senior reader evaluated 1199 OCT scans. Manual segmentation error correction (SEC) was performed. The frequency of SEC, resulting change in central retinal thickness after SEC, and reproducibility of SEC were quantified. Optical coherence tomography characteristics associated with the need for SECs were determined. Reading center teams graded all scans, and the reproducibility of ...

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      Mentions: Duke University
    3. Optical Coherence Tomography Predicts Visual Outcome in Acute Central Retinal Vein Occlusion

      Optical Coherence Tomography Predicts Visual Outcome in Acute Central Retinal Vein Occlusion

      Purpose: To investigate the clinical features of central retinal vein occlusion (CRVO) in relation to the presence of a prominent middle limiting membrane (p-MLM) sign on presenting optical coherence tomography, which may suggest macular ischemia and poor visual outcome. Methods: Fifty consecutive eyes with acute CRVO of <1 month of symptom duration before presentation were retrospectively reviewed. A hyperreflective line located in the outer plexiform layer (p-MLM) in optical coherence tomography was used as a sign of acute ischemia. Cases with p-MLM were grouped and compared with the group of eyes with no p-MLM sign (non-MLM group) for clinical features ...

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    4. Perspectives of an innovative ophthalmological technology: Optical coherence tomography (OCT) – What should be of interest to the neurologist?

      Perspectives of an innovative ophthalmological technology: Optical coherence tomography (OCT) – What should be of interest to the neurologist?

      Ocular coherence tomography has revolutionised the prospects of measuring the loss of retinal ganglion cells secondary to degenerative diseases and monitoring time-dependent changes of optic disc morphology, since the resolution has been improved considerably and the time required has been reduced. Although the non-invasive technique promises a high inter-session reproducibility, the limitations of retinal imaging and the problems of segmenting of the retinal layers have to be taken into account. While the first studies were limited to single sessions in small groups, further trials will elucidate how the retinal nerve fibre layer (RNFL) is altered in the course of different ...

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    5. Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema

      Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema

      Background: The pathogenesis of development and progression of neurosensory retinal detachment (NSD) in diabetic macular edema (DME) is not yet fully understood. The purpose of this study is to describe the spectral domain optical coherence tomography (SD-OCT) morphological characteristics of NSD associated with DME in the form of outer retinal communications and to assess the correlation between the size of communications and various factors. Materials and Methods: This was an observational retrospective nonconsecutive case series in a tertiary care eye institute. We imaged NSD and outer retinal communications in 17 eyes of 16 patients having NSD associated with DME using ...

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    6. Spectral-domain optical coherence tomography findings in chronic solar retinopathy

      Spectral-domain optical coherence tomography findings in chronic solar retinopathy

      Solar retinopathy is a clinical entity caused by any form of sun gazing most commonly attributed to solar eclipse viewing. [1] Other common causes include sunbathing, religious ritual, involving sun gazing, psychiatric illness, and military activities. [1] Solar retinopathy causes central visual distortion/loss. Acute cases present with typical history of sun exposure and easy to diagnose, but chronic cases are of challenge. Spectral-domain optical coherence tomography (SD-OCT) is a great tool to provide details comparable to histological changes. Here, we are discussing a patient with solar retinopathy diagnosed with the help of SD-OCT.

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    7. Classification of wet aged related macular degeneration using optical coherence tomographic images

      Classification of wet aged related macular degeneration using optical coherence tomographic images

      Wet Age related macular degeneration (AMD) is a type of age related macular degeneration. In order to detect Wet AMD we look for Pigment Epithelium detachment (PED) and fluid filled region caused by choroidal neovascularization (CNV). This form of AMD can cause vision loss if not treated in time. In this article we have proposed an automated system for detection of Wet AMD in Optical coherence tomographic (OCT) images. The proposed system extracts PED and CNV from OCT images using segmentation and morphological operations and then detailed feature set are extracted. These features are then passed on to the classifier ...

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    8. Development in anterior segment imaging for glaucoma

      Development in anterior segment imaging for glaucoma

      Purpose of review: Recent developments in anterior segment imaging enable high-resolution imaging with higher speeds than previous systems. This review will focus on advances in optical coherence tomography (OCT) imaging of the anterior segment with an emphasis on angle evaluation Recent findings: Anterior segment imaging with OCT is possible with both time domain and Fourier domain devices, and with light sources of different wavelengths. Recent studies have identified new risk factors for angle closure and prediction models incorporating quantitative angle width parameters have been developed for detection of gonioscopically defined angle closure. Swept source OCT is a variation of Fourier ...

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    9. Diagnosing progression with optical coherence tomography

      Diagnosing progression with optical coherence tomography

      Purpose of review: Optical coherence tomography (OCT) imaging of the retinal nerve fiber layer (RNFL), optic nerve head (ONH) and macula has gained popularity in recent years to detect and monitor glaucoma. With significant improvement in scan speed and scan resolution, spectral-domain OCT has become an efficient platform to evaluate progressive RNFL thinning and ONH remodeling. This review summarizes the recent progress of OCT RNFL, ONH and macular measurements for the detection of glaucoma progression. Recent findings: The RNFL thickness map facilitates visualization of RNFL defects and their progression patterns, and attains a higher sensitivity to detect glaucoma progression compared ...

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    10. OCT determined macular thickness in diabetic retinopathy and relation to colour vision deficiency patterns

      OCT determined macular thickness in diabetic retinopathy and relation to colour vision deficiency patterns

      Background: Diabetic retinopathy is the most common cause of blindness in industrialised nations and the incidence of diabetes is expected to rise over the next 10 years. Early treatment of proliferative diabetic retinopathy and diabetic maculopathy improves visual outcome and with effective screening, blindness could be reduced. Patients suffering from diabetes mellitus show alterations in their colour perception. Colour vision testing provides a sensitive, non-invasive method to assess macular damage in diabetic retinopathy and any deterioration in colour vision often precedes changes in other clinical measures such as visual acuity and morphological changes. Optical coherence tomography (OCT) provides cross-sectional images ...

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    11. The Diagnostic Function of OCT in Diabetic Maculopathy

      The Diagnostic Function of OCT in Diabetic Maculopathy

      Diabetic maculopathy (DM) is one of the major causes of vision impairment in individuals with diabetes. The traditional approach to diagnosis of DM includes fundus ophthalmoscopy and fluorescein angiography. Although very useful clinically, these methods do not contribute much to the evaluation of retinal morphology and its thickness profile. That is why a new technique called optical coherence tomography (OCT) was utilized to perform cross-sectional imaging of the retina. It facilitates measuring the macular thickening, quantification of diabetic macular oedema, and detecting vitreoretinal traction. Thus, OCT may assist in patient selection with DM who can benefit from treatment, identify what ...

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    12. Visante Anterior Segment Optical Coherence Tomography Analysis of Morphologic Changes After Deep Sclerectomy With Intraoperative Mitomycin-C and No Implant Use

      Visante Anterior Segment Optical Coherence Tomography Analysis of Morphologic Changes After Deep Sclerectomy With Intraoperative Mitomycin-C and No Implant Use

      Purpose: To assess long-term intrascleral space maintenance after nonpenetrating deep sclerectomy (NPDS) without implant placement and with application of intraoperative mitomycin-C, using Visante anterior segment optical coherence tomography (AS-OCT). Patients and Methods: This cross-sectional, observational, case series study examined 47 eyes from 47 consecutive patients who had undergone NPDS 58.34±23.77 months earlier. All participants underwent a complete ophthalmologic examination. The presence of intrascleral space and its maximum anteroposterior and transverse lengths, maximum height, and volume were evaluated. The thickness of the trabeculo-Descemet membrane, presence and type of any subconjunctival filtering bleb, as well as scleral and suprachoroidal ...

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    13. Development of a Semi-Automatic Segmentation Method for Retinal OCT Images Tested in Patients with Diabetic Macular Edema

      Development of a Semi-Automatic Segmentation Method for Retinal OCT Images Tested in Patients with Diabetic Macular Edema

      Purpose To develop EdgeSelect, a semi-automatic method for the segmentation of retinal layers in spectral domain optical coherence tomography images, and to compare the segmentation results with a manual method. Methods SD-OCT (Heidelberg Spectralis) scans of 28 eyes (24 patients with diabetic macular edema and 4 normal subjects) were imported into a customized MATLAB application, and were manually segmented by three graders at the layers corresponding to the inner limiting membrane (ILM), the inner segment/ellipsoid interface (ISe), the retinal/retinal pigment epithelium interface (RPE), and the Bruch's membrane (BM). The scans were then segmented independently by the same ...

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    14. Optical Coherence Tomography Monitoring Strategies for A-VEGF Treated Age-Related Macular Degeneration: An Evidence-Based Analysis

      Optical Coherence Tomography Monitoring Strategies for A-VEGF Treated Age-Related Macular Degeneration: An Evidence-Based Analysis

      Background: The emergence of new anti-angiogenesis pharmacotherapies has dramatically altered the treatment of age-related macular degeneration (AMD) the leading cause of blindness in older adults. The monthly intraocular injection treatment regime, however, is extremely burdensome to ophthalmologists, patients and their families and repeated injections also have increased risks of potential complications or adverse events such as infection, injury or immune reactions. Although the pharmacokinetics of A-VEGF drugs are fairly well known, variation in an individuals’ AMD presentation and their pharmacodynamics or response to the drug has been shown to be extremely variable. Therefore treating everyone on the same fixed regime ...

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    15. SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES IN FELLOW EYES OF PATIENTS WITH IDIOPATHIC MACULAR HOLE

      SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES IN FELLOW EYES OF PATIENTS WITH IDIOPATHIC MACULAR HOLE

      Purpose: To describe the vitreomacular interface and foveal structural changes in fellow eyes of patients with idiopathic macular holes using spectral-domain optical coherence tomography (SD-OCT). Methods: Retrospective analysis of consecutive medical records and SD-OCT images of the fellow eyes of patients with macular hole was done. Changes of the vitreoretinal interface and foveal structures on SD-OCT scan of the 101 fellow eyes of 101 subjects with full-thickness macular hole were studied and compared with 101 eyes of 101 age-matched healthy subjects. Results: Sixty-four patients (57.65%) were female. Mean age at presentation was 60.44 ± 12.17 years. The best-corrected ...

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    16. SOLITARY CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM FEATURES BY HIGH-DEFINITION OPTICAL COHERENCE TOMOGRAPHY

      SOLITARY CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM FEATURES BY HIGH-DEFINITION OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To describe the features of solitary congenital hypertrophy of the retinal pigment epithelium (CHRPE) using high-definition optical coherence tomography (HD-OCT). Methods: This was a retrospective, observational, noncomparative case series including 16 consecutive patients with solitary CHRPE. We describe the clinical and OCT features of CHRPE using the 5 radial lines acquisition OCT protocol over the CHRPE and the retina next to the tumor. Results: The mean patient age was 54 years (median 57 years; range 8-76 years). The CHRPE lesion was outside the posterior pole in 14 of the patients (8 temporal, 3 superior, 2 nasal, and 1 inferior ...

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    17. Spectral Domain Optical Coherence Tomography Predictors of Visual Outcome in Diabetic Cystoid Macular Edema After Bevacizumab Injection

      Spectral Domain Optical Coherence Tomography Predictors of Visual Outcome in Diabetic Cystoid Macular Edema After Bevacizumab Injection

      PURPOSE:: To study prognostic spectral domain optical coherence tomography parameters in diabetic cystoid macular edema after anti-vascular endothelial growth factor therapy. METHODS:: Retrospective cohort study included 49 eyes with the new onset diabetic cystoid macular edema that had to have a macular spectral domain optical coherence tomography and fluorescein angiography at presentation. The baseline optical coherence tomography scans were analyzed for variables indicative of the extent of retinal involvement by the cystoid change and its location about the center. Univariate and multivariate analyses were performed comparing the optical coherence tomography findings between the two groups of eyes: the "No improvement ...

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    18. The Dose-Dependent Macular Thickness Changes Assessed By FD-OCT in Patients With Retinitis Pigmentosa Treated With Ciliary Neurotrophic Factor

      The Dose-Dependent Macular Thickness Changes Assessed By FD-OCT in Patients With Retinitis Pigmentosa Treated With Ciliary Neurotrophic Factor

      Purpose: To evaluate the effect of intravitreal ciliary neurotrophic factor (CNTF) implant on mean macular thickness (MMT) in eyes with retinitis pigmentosa using high-resolution Fourier domain optical coherence tomography imaging. Methods: A cohort of 8 patients (CNTF-3: n = 5; CNTF-4: n = 3) enrolled in Neurotech sponsored Phase 2 clinical trial underwent Fourier domain optical coherence tomography imaging. A >=3% change in MMT from baseline or fellow eye was considered as a measurable change. Results: Two patients enrolled in the CNTF-3 study received low-dose implant. At 18 months, a change in MMT from -4.47 [mu]m to 6 [mu]m ...

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    19. Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Purpose : To describe the findings of optical coherence tomography and clinical characteristics in patients of zonal outer retinopathy associated with punctuate inner choroidopathy. Method : Review of consecutive cases on fundus photographs, spectral domain ocular coherence tomography, fluorescein angiography, indocyanine green angiography, visual field, and electrophysiological studies of patients with punctate inner choroidopathy and associated zonal outer retinopathy. Results : This study involves 4 patients suffering visual field defect far beyond the area corresponding to punctate inner choroidopathy lesions. Findings in optical coherence tomography include attenuated signals of photoreceptor inner/outer segment areas corresponding to visual field defect, and increased choroidal thickness ...

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    20. Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography

      Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography

      Purpose: To analyze age-related morphological changes of the iridocorneal angle in normal subjects and glaucomatous cases, using anterior segment optical coherence tomography (AS-OCT). Methods: This study involved 58 eyes of 58 open-angle glaucoma cases and 72 eyes of 72 age-matched normal-open-angle control subjects. Iridocorneal angle structures in nasal and temporal regions and anterior chamber depth (ACD) were measured using AS-OCT. Axial length and refractive error were measured by use of an ocular biometer and auto refractor keratometer. Angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA), measured at 500 µm (TISA500) and 750 µm (TISA750) distant ...

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    21. Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Purpose : To describe the findings of optical coherence tomography and clinical characteristics in patients of zonal outer retinopathy associated with punctuate inner choroidopathy . Method : Review of consecutive cases on fundus photographs, spectral domain ocular coherence tomography, fluorescein angiography, indocyanine green angiography, visual field, and electrophysiological studies of patients with punctate inner choroidopathy and associated zonal outer retinopathy . Results : This study involves 4 patients suffering visual field defect far beyond the area corresponding to punctate inner choroidopathy lesions. Findings in optical coherence tomography include attenuated signals of photoreceptor inner / outer segment areas corresponding to visual field defect, and increased choroidal thickness ...

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    22. Glaucoma Diagnostic Accuracy of Machine Learning Classifiers Using Retinal Nerve Fiber Layer and Optic Nerve Data from SD-OCT

      Glaucoma Diagnostic Accuracy of Machine Learning Classifiers Using Retinal Nerve Fiber Layer and Optic Nerve Data from SD-OCT

      To investigate the diagnostic accuracy of machine learning classifiers (MLCs) using retinal nerve fiber layer (RNFL) and optic nerve (ON) parameters obtained with spectral domain optical coherence tomography (SD-OCT). Methods . Fifty-seven patients with early to moderate primary open angle glaucoma and 46 healthy patients were recruited. All 103 patients underwent a complete ophthalmological examination, achromatic standard automated perimetry, and imaging with SD-OCT. Receiver operating characteristic (ROC) curves were built for RNFL and ON parameters. Ten MLCs were tested. Areas under ROC curves (aROCs) obtained for each SD-OCT parameter and MLC were compared. Results . The mean age was years for healthy ...

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    23. Thickness Mapping of Eleven Retinal Layers in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      Thickness Mapping of Eleven Retinal Layers in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      Purpose. This study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Methods. Mean regional retinal thickness of 11 retinal layers were obtained by automatic three-dimensional diffusion-map-based method in 112 normal eyes of 76 Iranian subjects. Results. The thickness map of central foveal area in layer 1, 3, and 4 displayed the minimum thickness (P<0.005 for all). Maximum thickness was observed in nasal to the fovea of layer 1 (P<0.001) and in a circular pattern in ...

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