1. Articles in category: Ophthalmology

    553-576 of 5999 « 1 2 ... 21 22 23 24 25 26 27 ... 248 249 250 »
    1. University of Memphis Receives NIH Grant For New Techniques for Measuring Volumetric Structural changes in Glaucoma

      University of Memphis Receives NIH Grant For New Techniques for Measuring Volumetric Structural changes in Glaucoma

      University of Memphis Received a 204 NIH Grant for $248,999 to Study New Techniques for Measuring Volumetric Structural changes in Glaucoma. The principal Investigator is Madhusudhanan Balasubramanian. The program began in 2014 and ends in 2016. Below is a summary of the proposed work. This K99/R00 application supports additional research training in computational mathematics and computer vision which will enable Dr. Madhusudhanan Balasubramanian-the applicant, to become an independent multidisciplinary investigator in computational ophthalmology. Specifically, in the K99 training phase of this grant, Dr. Balasubramanian will train at UC San Diego under the direction of Linda Zangwill PhD, an ...

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    2. Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT

      Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT

      Introduction: To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD). Material and Methods: This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fibre layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects. Results: Patients with AD ...

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    3. Quantification of the neurodegenerative status in patients with multiple sclerosis by optical coherence tomography in respect to functional vision (Thesis)

      Quantification of the neurodegenerative status in patients with multiple sclerosis by optical coherence tomography in respect to functional vision (Thesis)

      Multiple sclerosis is the most frequent, non-traumatic, neurological disorder in young adults in western countries which leads to chronic impairment. The cause of the immune mediated illness remains elusive. Neither clinical nor paraclinical measures can estimate the disability degree or the course of multiple sclerosis (MS). It is crucial to improve the methods which can be a window to the neurodegenerative status of individuals. Structural investigations of the ZNS by MRI own a key position but discriminate between demyelinisation and axonal damage insufficiently and show a discrepancy between lesion load and clinical symptoms. The axonal degeneration goes in line with ...

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    4. Evaluation of Retinal and Choroidal Thickness By Swept-Source Optical Coherence Tomography: Repeatability and Assessment of Artifacts

      Evaluation of Retinal and Choroidal Thickness By Swept-Source Optical Coherence Tomography: Repeatability and Assessment of Artifacts

      Purpose To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS-OCT) and the frequency and type of scan artifacts. Design Prospective evaluation of new diagnostic technology. Methods Thirty healthy subjects were recruited prospectively and underwent imaging with a prototype SS-OCT instrument. Undilated scans of 54 eyes of 27 subjects (mean age 35.1 ± 9.3 years) were obtained. Each subject had four SS-OCT protocols repeated three times: three-dimensional (3D) 6x6-mm raster scan of the optic disc and macula, radial, and line scan. Automated measurements were obtained through segmentation software. Inter-scan repeatability was assessed ...

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    5. Effect of Scan Quality on Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

      Effect of Scan Quality on Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

      Purpose To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) parameters of spectral-domain optical coherence tomography (SD OCT) in glaucoma. Design Cross-sectional study. Methods Two hundred fifty-two eyes of 183 control subjects (mean deviation [MD]: −1.84 dB) and 207 eyes of 159 glaucoma patients (MD: −7.31 dB) underwent ONH, RNFL, and GCC scanning with SD OCT. Scan quality of SD OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD OCT was evaluated ...

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    6. Derby £20 eye test saved my life, says Mickleover man Steve Trower

      Derby £20 eye test saved my life, says Mickleover man Steve Trower

      A FATHER-OF-TWO says he would not be alive today if a routine eye examination had not revealed that he was suffering from a rare form of cancer. Steve Trower had never had his sight tested before his visit to Richard Petrie opticians, in Littleover, after he noticed he was starting to squint while watching television. But the examination revealed that the 52-year-old plumber had bleeding at the back of one of his eyes and he was referred to his GP for tests. Within two weeks, he was receiving intensive chemotherapy treatment for myeloma – a cancer of the bone marrow – which ...

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    7. Spectral-domain optical coherence tomography evaluation of postoperative cystoid macular oedema following phacoemulsification with intraoperative complication

      Spectral-domain optical coherence tomography evaluation of postoperative cystoid macular oedema following phacoemulsification with intraoperative complication

      Background To report the rate of cystoid macular oedema (CMO) as detected by spectral-domain optical coherence tomography (SD-OCT) after intraoperative complication during phacoemulsification. The secondary objectives include comparing mean macular thickness and best-corrected visual acuity (BCVA) between those who developed postoperative CMO against those who did not. Methods This is a prospective cohort study conducted in a tertiary hospital between July 2009 and June 2010. Serial SD-OCT and BCVA were performed at baseline, 1 week, 6 weeks and 16 weeks postoperatively. Results Single eyes from 47 subjects were analyzed; of these 16 (34%) eyes developed CMO. In the CMO group ...

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    8. Feature Of The Week 2/16/14: En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopath

      Feature Of The Week 2/16/14: En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopath

      We characterized en face features of the retinal pigment epithelium (RPE) and choroid in eyes with chronic central serous chorioretinopathy (CSCR) using a high-speed, enhanced tissue penetration, swept-source optical coherence tomography (SS-OCT) prototype. Fifteen eyes of 13 consecutive patients with the clinical diagnosis of CSCR were prospectively examined with SS-OCT. Three-dimensional 6x6mm macular cube raster scans were obtained with SS-OCT operating at 1050nm wavelength and 100,000 A-lines/sec with 6µm axial resolution. Segmentation of the RPE generated a reference surface; en face SS-OCT images of the RPE and choroid were extracted at varying depths every 3.5 µm ...

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    9. Comparison of Time- and Spectral-Domain Optical Coherence Tomography in Management of Diabetic Macular Edema

      Comparison of Time- and Spectral-Domain Optical Coherence Tomography in Management of Diabetic Macular Edema

      Purpose: Some clinical trials that proved the benefits of anti-VEGF therapy for diabetic macular edema (DME) based retreatment decisions on visual acuity and time-domain ocular coherence tomography (TD-OCT) central subfield thickness changes since the last treatment. This study assessed the impact of TD-OCT followed by spectral domain (SD)-OCT on as needed treatment decision-making in the management of DME with anti-VEGF medications. Methods: Patients previously treated for DME with anti-VEGF medications in the Retina Division of the Wilmer Eye Institute, following an IRB approved informed consent process, underwent clinical examination, TD- and SD-OCT imaging. Their retina specialists recorded whether additional ...

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    10. Quantitative Fundus Autofluorescence and Optical Coherence Tomography in Best Vitelliform Macular Dystrophy

      Quantitative Fundus Autofluorescence and Optical Coherence Tomography in Best Vitelliform Macular Dystrophy

      Purpose: Quantitative fundus autofluorescence (qAF), spectral domain optical coherence tomography (SD-OCT) segmentation and multimodal imaging were performed to elucidate the pathogenesis of Best vitelliform macular dystrophy (BVMD) and to identify abnormalities in lesion versus non-lesion fundus areas. Methods: 16 patients with a clinical diagnosis of BVMD were studied. AF images (30°, 488 nm excitation) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal fluorescent reference to account for variable laser power and detector sensitivity. The grey levels (GLs) of each image were calibrated to the reference, zero GL, magnification, and normative optical media density, to yield qAF ...

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    11. Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

      Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

      Importance Spectral-domain optical coherence tomography (SD-OCT) has an integral role in the diagnosis and treatment of glaucoma. Understanding the types of artifacts commonly seen in the imaging of patients being evaluated for glaucoma will help physicians better implement these data in the care of patients. Objectives To determine the frequency and distribution of SD-OCT imaging artifacts in patients being evaluated for glaucoma and to provide examples of common artifacts. Design, Setting, and Participants A retrospective cross-sectional study design was used to examine SD-OCT images (using Spectralis SD-OCT) of 277 consecutive patients who had a diagnosis of glaucoma of any stage ...

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    12. Macular optical coherence tomography findings and GPR143 mutations in patients with ocular albinism

      Macular optical coherence tomography findings and GPR143 mutations in patients with ocular albinism

      The aim of this study was to describe macular findings using spectral-domain optical coherence tomography (SD-OCT) in patients with ocular albinism (OA) and their carrier mothers, and to identify the frequency of GPR143 gene mutations in these patients. The study included five patients with a clinical diagnosis of OA. SD-OCT of the macular area was performed in both patients and their mothers. The anatomical characteristics of the macula and retinal pigment epithelium (RPE), patterns of autofluorescence and infrared imaging were analyzed. Polymerase chain reaction amplification of the complete coding sequence of GPR 143 was performed and subsequently analyzed by direct ...

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    13. Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography

      Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography

      Purpose: Sodium iodate induces retinal pigment epithelium (RPE) atrophy and photoreceptor degeneration, as seen in the pathogenesis of many retinal diseases. We investigated a new approach of analyzing retinal images using confocal scanning laser ophthalmoscopy (cSLO), which allows longitudinal assessment of sodium iodate induced lesions in the retina of living rats. Methods: Single dose of sodium iodate (25 to 75 mg/kg) was given intravenously to adult Sprague-Dawley rats. Control animals were given normal saline or sodium iodide. The retina was examined by cSLO and optical coherence tomography (OCT) in living rats, which were then sacrificed for histological assessments. Results ...

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    14. Detection and Analysis of Hard Exudates by Polarization-Sensitive Optical Coherence Tomography in Patients with Diabetic Maculopathy

      Detection and Analysis of Hard Exudates by Polarization-Sensitive Optical Coherence Tomography in Patients with Diabetic Maculopathy

      Purpose: To image and analyze hard exudates (HE) and their precursors in patients with diabetic macular edema (DME) using polarization sensitive optical coherence tomography (PS-OCT). Methods: Twenty-two eyes of 16 patients with DME were imaged using color fundus photography (CF) and PS-OCT. In PS-OCT, HE were automatically detected based on their distinct polarization-scrambling qualities. CF images were manually graded for the presence of HE by two masked graders and correlated with the corresponding PS-OCT HE maps: corresponding images were overlaid and an identical grid of 128x128 fields was used for correlation of detected HE. Results: In all eyes, HE were ...

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    15. Epithelial and Stromal Remodeling After Corneal Collagen Cross-linking Evaluated by Spectral-Domain OCT

      Epithelial and Stromal Remodeling After Corneal Collagen Cross-linking Evaluated by Spectral-Domain OCT

      PURPOSE: To evaluate changes in corneal epithelial and stromal thickness after corneal collagen cross-linking (CXL) in eyes with keratoconus and postoperative corneal ectasia using spectral-domain optical coherence tomography (SD-OCT). METHODS: Anterior segment SD-OCT (RTVue-100; Optovue, Inc., Fremont, CA) was used to compare regional corneal epithelial and stromal thickness in eyes with keratoconus and ectasia before CXL and 1 and 3 months after CXL. The anterior surface of the cornea, epithelium–Bowman’s layer interface, and posterior reflective surface were used as anatomical landmarks to measure epithelial and stromal thickness, respectively. Regional thickness was assessed centrally and at 21 points 0 ...

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    16. Optical coherence tomography combined with videokeratography to differentiate mild keratoconus subtypes

      Optical coherence tomography combined with videokeratography to differentiate mild keratoconus subtypes

      PURPOSE: To develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to detect early keratoconus. METHODS: Videokeratography, wavefront analysis, and measured OCT indices were performed on 180 normal eyes, 46 eyes with moderate keratoconus, 54 eyes with early keratoconus, 7 eyes with forme fruste keratoconus, and 16 eyes with keratoconus "suspect" to determine the most sensitive parameters for separating these groups. RESULTS: A combination of videokeratography and OCT indices (inferior-superior [I-S] value and minimum pachymetry) was statistically the most significant in separating the keratoconus groups from normal eyes (P < .001). Using a newly derived index, the minimum ...

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    17. Heidelberg Spectralis OCT Eye Examinations in Space

      Heidelberg Spectralis OCT Eye Examinations in Space

      Since its arrival at the International Space Station (ISS) on June 15 th , 2013, Heidelberg Engineering’s Spectralis OCT device is being used regularly for eye examinations of ISS crewmembers. First on-orbit tests of the instrument were conducted successfully on June 21 of last year. The first ever OCT examination in space was performed with a commercial SPECTRALIS OCT device on board ISS on October 16, 2013. Since then, ISS crewmembers are being examined in 1- to 2-week intervals. The examinations are part of NASA’s Ocular Health Study, which seeks to understand ocular changes in astronauts during long-term space ...

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    18. Optical Coherence Tomography in Parkinson's Disease: Is the Retina a Biomarker?

      Optical Coherence Tomography in Parkinson's Disease: Is the Retina a Biomarker?

      Visual symptoms are a common feature in patients with Parkinson's disease (PD), and retinal dopamine loss and dysfunctions in foveal vision have been described in PD patients. Because visual hallucination (VH) is a specific feature of PD which is differentiated from other parkinsonian disorders, defective visual information processing from both the central and peripheral pathways is suggested to be the pathophysiological mechanisms of VH in PD. Decreased visual acuity as well as impaired contrast sensitivity and color vision is known to be related to the appearance of VH in PD. However, these functional studies were also affected by cognitive ...

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    19. Optical coherence tomography: a quantitative tool to screen for papilledema in craniosynostosis

      Optical coherence tomography: a quantitative tool to screen for papilledema in craniosynostosis

      Purpose Our aim was to evaluate if optical coherence tomography (OCT) can be used as an alternative for fundoscopy to screen for increased intracranial pressure (ICP) in children with craniosynostosis Methods We performed a prospective cohort study at the Dutch Craniofacial Centre. We included 38 patients with nonsyndromic scaphocephaly and Crouzon’s syndrome aged 3–8 years old, in whom we scored complaints suggestive of increased ICP and performed fundoscopy and OCT. Main outcome measures total retinal thickness (TRT) which was measured on 58 OCT scans. Results Forty-three percent of fundoscopies revealed pathologic changes of the papil in at least ...

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    20. Reproducibility of disc and macula optical coherence tomography using the Canon OCT-HS100 as compared with the Zeiss Cirrus HD-OCT

      Reproducibility of disc and macula optical coherence tomography using the Canon OCT-HS100 as compared with the Zeiss Cirrus HD-OCT

      Purpose: In a clinical setting, the usefulness of optical coherence tomography (OCT) is strongly dependent on reproducibility of the measurement. The aim of the present study was to evaluate macula and optic disc measurement reproducibility with the new spectral-domain OCT (SD-OCT) from Canon (Canon OCT-HS100) and to compare reproducibility and obtained measurements with the Zeiss Cirrus HD-OCT. Methods: Macula and optic disc parameters from the right eyes of 31 subjects were obtained twice with both instruments. Interoperator reproducibility was evaluated by use of the coefficient of repeatability (CR), and the obtained measurements were compared between the instruments. Results: No difference ...

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    21. Optical coherence tomography in the diagnosis and management of uveitis

      Optical coherence tomography in the diagnosis and management of uveitis

      Optical coherence tomography (OCT) has become an integral tool in the imaging of numerous diseases of the posterior segment. The diagnostic investigation of infectious and noninfectious uveitic conditions often requires multiple imaging modalities in the appropriate clinical context. Modern OCT technology has proved useful not only in the diagnostic investigation of these conditions, but also in monitoring of their clinical course and therapeutic response. Inflammation-induced changes at the level of the retina, retinal pigment epithelium, and choroid can now easily be identified in these conditions using OCT. Prognostic information on visual acuity outcome can also be estimated based on OCT ...

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    22. Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

      Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

      Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded reflective core packed with hyperreflective dots bearing a superficial similarity to the photoreceptors in the unaffected retina. However, AO-OCT suggested that the speckled appearance over the SDD rendered by AO-SLO was the lesion material itself, rather than photoreceptors. AO-OCT assists proper interpretation and understanding of the SDD structure and the lesions’ impact on surrounding photoreceptors ...

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    23. Relationship between Severity of Obstructive Sleep Apnea Syndrome and Retinal Nerve Fiber Layer Thickness

      Relationship between Severity of Obstructive Sleep Apnea Syndrome and Retinal Nerve Fiber Layer Thickness

      Purpose To determine if there is a significant correlation between the peripapillary retinal nerve fiber layer (RNFL) thickness, foveal thickness, total macular volume, and the severity of obstructive sleep apnea syndrome. DESIGN: Prospective study. Methods One hundred twenty-eight consecutive subjects who underwent polysomnography were studied. Optical coherence tomography (OCT) was used to measure the peripapillary RNFL, foveal thickness, and total macular volume. The Pearson correlation coefficient was used to determine the relationship between the apnea-hypopnea index and OCT and other parameters. Multiple regression analysis was used to determine the independent factors for the RNFL sectors that were the most strongly ...

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