1. Articles in category: Ophthalmology

    553-576 of 7989 « 1 2 ... 21 22 23 24 25 26 27 ... 331 332 333 »
    1. Spectral-Domain Optical Coherence Tomography Imaging in 67,321 Adults

      Spectral-Domain Optical Coherence Tomography Imaging in 67,321 Adults

      Purpose To derive macular thickness measures and their associations by performing rapid, automated segmentation of spectral-domain optical coherence tomography (SD OCT) images collected and stored as part of the UK Biobank (UKBB) study. Design Large, multisite cohort study in the United Kingdom. Analysis of cross-sectional data. Participants Adults from the United Kingdom aged 40 to 69 years. Methods Participants had nonmydriatic SD OCT (Topcon 3D OCT-1000 Mark II; Topcon GB, Newberry, Berkshire, UK) performed as part of the ocular assessment module. Rapid, remote, automated segmentation of the images was performed using custom optical coherence tomography (OCT) image analysis software (Topcon ...

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    2. IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP

      IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP

      Purpose: To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging . Methods: A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography, and adaptive-optics optical coherence tomography . Results: Three distinct acute episodes of MEWDS occurred during the period of follow-up. Fourier-domain optical coherence tomography and adaptive-optics imaging showed disturbance in the photoreceptor ...

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    3. Sequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiography

      Sequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiography

      Purpose: To assess and describe sequential morphological changes in the choroidal neovascularization (CNV) net using optical coherence tomography angiography (OCTA) in patients undergoing treatment with intravitreal antivascular endothelial growth factor (VEGF). Methods: Prospective cohort study. OCTA was performed sequentially: before (t0), 1 h (t1), 1 week (t2) and 1 month after the injection (t3), using Avanti RTVue XR equipped with the AngioVue® software (Optovue, Calif., USA). All images were classified by two independent graders. Results: Ten eyes of 10 patients, with a mean age of 72.4 ± 10.5 years, were included. CNV morphology was described as tree-like in 5 ...

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    4. Simulation of cellular changes on Optical Coherence Tomography of human retina

      Simulation of cellular changes on Optical Coherence Tomography of human retina

      We present a methodology to assess cell level alterations on the human retina responsible for functional changes observable in the Optical Coherence Tomography data in healthy ageing and in disease conditions, in the absence of structural alterations. The methodology is based in a 3D multilayer Monte Carlo computational model of the human retina . The optical properties of each layer are obtained by solving the Maxwell's equations for 3D domains representative of small regions of those layers, using a Discontinuous Galerkin Finite Element Method (DG-FEM). Here we present the DG-FEM Maxwell 3D model and its validation against Mie's theory ...

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    5. Brave New World: OCT Angiography A Video: Dr. Reichel Reviews OCTA with Drs. Prenner and Kaiser

      Brave New World: OCT Angiography A Video: Dr. Reichel Reviews OCTA with Drs. Prenner and Kaiser

      Elias Reichel, MD, joined Jonathan L. Prenner, MD, and Richard S. Kaiser, MD, for a recent installment of the Retina Today Journal Club. He answered their questions about an imaging technology that will soon be commercially available: optical coherence tomography angiography (OCTA). Dr. Kaiser noted that when many retina doctors first trained, they relied on fluorescein angiography (FA), which offered a limited view of the fundus, before relying on OCT, which revolutionized the clinic. Soon, OCTA may be the next imaging device that revolutionizes the way retina specialists evaluate retinal anatomy. “Now we’re at a precipice of potentially a ...

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    6. Total retinal blood flow measurement by three beam Doppler optical coherence tomography

      Total retinal blood flow measurement by three beam Doppler optical coherence tomography

      We present measurements of total retinal blood flow in healthy volunteers using a three beam Doppler optical coherence tomography (D-OCT) technique. This technology has the advantage of a precise determination of the flow vector without the use of any a-priori information on the vessel geometry. Circular D-OCT scans around the optic disc were recorded and venous as well as arterial total blood flow was determined and compared for each subject. The reproducibility of the method was assessed in 6 subjects by repeated measurements. Only small deviations of around 6% between the measurements were found which indicates the high precision of ...

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    7. Post-Doc Position in Structural and Functional High-Resolution Retinal Imaging at the University of California, Davis

      Post-Doc Position in Structural and Functional High-Resolution Retinal Imaging at the University of California, Davis

      Applications are invited for a post-doctoral research associate position in the Vision Science and Advanced Retinal Imaging Laboratory ( http://vsri.ucdavis.edu/ ) at the UC Davis Medical Center. The goal of our research is to develop the next generation of cellular resolution multimodal retinal imaging instruments to study age-related changes in vision and retinal disorders. The ideal candidate will have strong skills in some combination of retinal imaging modalities, including by not limited to AO, OCT, SLO, multispectral imaging, fluorescence, etc. A Ph.D. or comparable advanced degree in a relevant area is required (e.g., Biomedical Engineering, Computer Science ...

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    8. Pioneering Glaucoma Expert Appointed Chair of the Department of Ophthalmology at NYU Langone Medical Center

      Pioneering Glaucoma Expert Appointed Chair of the Department of Ophthalmology at NYU Langone Medical Center

      Internationally renowned clinician-scientist Joel S. Schuman , MD, whose pioneering work has led to significant advances in the detection and treatment of glaucoma, was appointed chair of the Department of Ophthalmology at NYU Langone Medical Center, effective January 1, 2016 . Dr. Schuman joins NYU Langone following a notable career at the University of Pittsburgh School of Medicine, where he was a distinguished professor and chair of ophthalmology, and the director of the UPMC Eye Center. Dr. Schuman also held appointments at the university's McGowan Institute for Regenerative Medicine, the Center for the Neural Basis of Cognition, and as professor of ...

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    9. Changes in morphology and visual function over time in mouse models of retinal degeneration: an SD-OCT, histology, and electroretinography study

      Changes in morphology and visual function over time in mouse models of retinal degeneration: an SD-OCT, histology, and electroretinography study

      Purpose To examine the long-term natural course of retinal degeneration in rd10 and rd12 mice using serial spectral-domain optical coherence tomography (SD-OCT), electroretinography/electroretinograms (ERGs), and histological analysis. Methods Photoreceptor layer thickness and the ability to visualize photoreceptor ellipsoid zones were analyzed using SD-OCT images, and these images were compared with hematoxylin and eosin-stained sections and electron microscopy images. The a- and b-wave amplitudes of the ERGs were analyzed. Results In rd10 mice, the photoreceptor layer thickness rapidly decreased, and the photoreceptor ellipsoid zone was visible on SD-OCT images in 89 and 43 % of eyes of 21 and 33-day-old mice ...

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    10. Intraoperative spectral domain optical coherence tomography; Its time has come

      Intraoperative spectral domain optical coherence tomography; Its time has come

      Vitreoretinal surgery has experienced an explosion of advances in the last decade and a half. New advances in pars plana vitrectomy systems including small-gauge instrumentation have provided many potential benefits to patients and surgeons. These include more efficient surgery; decreased postoperative inflammation leading to less pain and more patient comfort; improved cosmetic appearance following surgery; decreased astigmatic changes; and more rapid visual recovery. Pharmacotherapy and chromovitrectomy have facilitated pars plana vitrectomy and peeling of membranes. Better visualization with better microscopes and optics is also available. Advances and technology continue to add to the explosion of possibilities available in our armamentarium ...

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    11. Macular surgery using intraoperative spectral domain optical coherence tomography

      Macular surgery using intraoperative spectral domain optical coherence tomography

      Purpose: To report the use of intraoperative spectral domain optical coherence tomography (SD-OCT) for detecting anatomical changes during macular surgery. Methods: In a consecutive case series, 32 eyes of 32 patients undergoing concurrent pars plana vitrectomy and intraoperative SD-OCT for macular hole (MH), epiretinal membrane (ERM) and vitreomacular traction (VMT) were enrolled. Intraoperative changes in retinal thickness and dimensions of the macular hole were measured in patients with ERM and VMT following surgical manipulation using a hand-held SD-OCT device (iVue, Optovue Inc., Fremont, CA, USA). Results: SD-OCT images of sixteen eyes with macular hole were subjected to quantitative and qualitative ...

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    12. Use of Handheld Intraoperative Spectral-Domain Optical Coherence Tomography in a Variety of Vitreoretinal Diseases

      Use of Handheld Intraoperative Spectral-Domain Optical Coherence Tomography in a Variety of Vitreoretinal Diseases

      BACKGROUND AND OBJECTIVE: The use of intraoperative optical coherence tomography (iOCT) has been described with a variety of imaging devices and techniques. The purpose of this investigation is to examine the role of iVue (Optovue, Fremont, CA), a commercially available, handheld spectral-domain iOCT system, in vitreoretinal surgery. PATIENTS AND METHODS For this retrospective, observational case series, patients who underwent a vitreoretinal surgical procedure and were imaged with the iVue were identified. Images were qualitatively assessed. RESULTS: Five cases were identified, including an examination under anesthesia, epiretinal membrane, macular hole, retinal detachment, and non-clearing vitreous hemorrhage in the setting of proliferative ...

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    13. Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Choroidal Osteoma

      Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Choroidal Osteoma

      Choroidal osteoma is an ossifying tumor that is found predominantly in the peripapillary and macular areas. It typically affects otherwise healthy females. Vision loss may occur secondary to the development of choroidal neovascularization (CNV). Fluorescein angiography (FA) remains the gold standard for diagnosing CNV; however, the use of optical coherence tomography angiography (OCTA) as an adjunct to FA is growing. In this report, a 16-year-old female with a large, unilateral peripapillary choroidal osteoma presented with blurred vision. Exam revealed scattered intraretinal hemorrhage, but FA was unable to detect CNV overlying the tumor. OCTA detected abnormal flow in the outer retina ...

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    14. OCT Angiography Identification of Choroidal Neovascularization Secondary to Acute Zonal Occult Outer Retinopathy

      OCT Angiography Identification of Choroidal Neovascularization Secondary to Acute Zonal Occult Outer Retinopathy

      A 74-year-old female with acute zonal occult outer retinopathy presented with a new lesion suspicious for choroidal neovascularization (CNV) in her right eye. Optical coherence tomography angiography (OCTA) confirmed the presence of CNV. OCTA is a new imaging technique that may help guide diagnosis and management of choroidal neovascular membranes in uveitic diseases.

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    15. Inflatable medical interfaces and other medical devices, systems, and methods

      Inflatable medical interfaces and other medical devices, systems, and methods

      An inflatable mask with two ocular cavities can seal against a user's face by forming an air-tight seal around the periphery of the user's eye socket. The sealed air-tight ocular cavity can be pressurized to take ocular measurements. The mask can conform to the contours of a user's face by inflating or deflating the mask. In addition, the distance between the user and a medical device (e.g. an optical coherence tomography instrument) can be adjusted by inflating or deflating the mask. Also disclosed herein is an electronic encounter portal and an automated eye examination. Other embodiments ...

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    16. Systems and methods for automated classification of abnormalities in optical coherence tomography images of the eye

      Systems and methods for automated classification of abnormalities in optical coherence tomography images of the eye

      Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.

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    17. Method for monitoring image of examinee's eye and monitoring system

      Method for monitoring image of examinee's eye and monitoring system

      A method for monitoring an image of an examinee's eye includes: obtaining first image data including a first examinee's eye image captured by a first ophthalmologic photographing apparatus, and additional information including type information on the first examinee's eye image; obtaining second image data including a second examinee's eye image captured by a second ophthalmologic photographing apparatus different from the first ophthalmologic photographing apparatus, and additional information including type information on the second examinee's eye image; recognizing the first examinee's eye image and the second examinee's eye image as the same type of ...

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      Mentions: Nidek
    18. Feasibility of Spectral Domain Optical Coherence Tomography Acquisition Using a Handheld Versus Conventional Tabletop Unit

      Feasibility of Spectral Domain Optical Coherence Tomography Acquisition Using a Handheld Versus Conventional Tabletop Unit

      Purpose: Patients afflicted with ocular complications of diabetes represent a diverse demographic who often cannot undergo spectral-domain optical coherence tomography (SD-OCT) imaging of the retina due to postural restraints. Our pilot study compared imaging acquisition methods using SD-OCT in the handheld (HH) mode versus the conventional tabletop (TT) method. Methods: Our study included 22 undilated eyes of 22 subjects (mean ± SD age, 35.8 ± 16.8 years) imaged using HH and TT iVue SD-OCT (Optovue, Fremont, CA). Statistical analysis was performed using Microsoft Excel 12.2.7 (Microsoft Corporation, Redmond, WA) software with an accepted significance of P < .05. Results ...

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    19. Comparison of Prevalence of Diabetic Macular Edema Based on Monocular Fundus Photography vs Optical Coherence Tomography

      Comparison of Prevalence of Diabetic Macular Edema Based on Monocular Fundus Photography vs Optical Coherence Tomography

      Importance Diagnosing diabetic macular edema (DME) from monocular fundus photography vs optical coherence tomography (OCT) central subfield thickness (CST) can yield different prevalence rates for DME. Epidemiologic studies and telemedicine screening typically use monocular fundus photography, while treatment of DME uses OCT CST. Objective To compare DME prevalence from monocular fundus photography and OCT. Design, Setting, and Participants Retrospective cross-sectional study of DME grading based on monocular fundus photographs and OCT images obtained from patients with diabetic retinopathy at a single visit between July 1, 2011, and June 30, 2014, at a university-based practice and analyzed between July 30, 2014 ...

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    20. Semi-automated quantification of retinal IS/OS damage in en-face OCT image

      Semi-automated quantification of retinal IS/OS damage in en-face OCT image

      A variety of vision ailments are indicated by structural changes in the retinal substructures of the posterior segment of the eye. In particular, integrity of the inner-segment/outer-segment (IS/OS) junction directly relates to the visual acuity. In the en-face optical coherence tomography (OCT) image, IS/OS damage manifests as a dark spot in the foveal region, and its quantification, usually performed by experts, assumes diagnostic significance. In this context, in view of the general scarcity of experts, it becomes imperative to develop algorithmic methods to reduce expert time and effort. Accordingly, we propose a semi-automated method based on level ...

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    21. En Face Optical Coherence Tomography to Detect and Measure Geographic Atrophy

      En Face Optical Coherence Tomography to Detect and Measure Geographic Atrophy

      Purpose : To detect and quantify geographic atrophy (GA) secondary to age-related macular degeneration using en face optical coherence tomography (OCT) and to correlate it to GA measured with fundus autofluorescence (FAF). Methods : Twenty-four consecutive patients (27 eyes) were studied with both standard (STD)- and enhanced depth imaging (EDI)-OCT. En face OCT images were obtained at the outer retinal layer (OR) and at the choroidal layer (CH) level for both STD- and EDI-OCT. Areas of GA were measured on the en face OCT images and were correlated with the GA areas measured on blue (B)- and near infrared (NIR)-wavelength ...

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    22. Macular microangiopathy in sickle cell disease using optical coherence tomography angiography

      Macular microangiopathy in sickle cell disease using optical coherence tomography angiography

      Purpose To characterize the optical coherence tomography angiography (OCTA) appearance of the perifoveal macular microvasculature in visually asymptomatic patients with sickle cell disease, and to compare these findings with those of fluorescein angiography (FA). Design Retrospective observational case series. Methods Eighteen eyes of 9 consecutive patients with a median age of 41 years (range: 19-54) with electrophoretic confirmation of sickle cell disease were included and analyzed. A complete ophthalmologic examination was performed, including fundus examination, FA (Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany), and OCTA (RTVue XR Avanti, Optovue Inc, Fremont, California, USA). Nine eyes of five healthy subjects were ...

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    23. OCT-based crystalline lens topography in accommodating eyes

      OCT-based crystalline lens topography in accommodating eyes

      ustom Spectral Domain Optical Coherence Tomography (SD-OCT) provided with automatic quantification and distortion correction algorithms was used to measure anterior and posterior crystalline lens surface elevation in accommodating eyes and to evaluate relationships between anterior segment surfaces. Nine young eyes were measured at different accommodative demands. Anterior and posterior lens radii of curvature decreased at a rate of 0.78 ± 0.18 and 0.13 ± 0.07 mm/D, anterior chamber depth decreased at 0.04 ± 0.01 mm/D and lens thickness increased at 0.04 ± 0.01 mm/D with accommodation. Three-dimensional surface elevations were estimated by subtracting ...

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    24. Re: McNabb et al.: Optical coherence tomography accurately measures corneal power change from laser refractive surgery (Ophthalmology 2015;122:677-86)

      Re: McNabb et al.: Optical coherence tomography accurately measures corneal power change from laser refractive surgery (Ophthalmology 2015;122:677-86)

      I read with interest the article by McNabb et al 1 regarding the measurement of corneal power in eyes that have undergone refractive surgery. One of the study's limitations was that myopic and hyperopic eyes were analyzed in a single group. It is known that after refractive surgery there is an overestimation of the corneal power in the eyes that had surgery for myopia, 2,3 and there is an underestimation of the power of the cornea in eyes that had surgery for hyperopia. 4 Evaluating the overall differences in corneal power for both refractive defects may introduce bias ...

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