1. Articles in category: Ophthalmology

    553-576 of 6413 « 1 2 ... 21 22 23 24 25 26 27 ... 266 267 268 »
    1. Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Purpose To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display. Design Observational prospective cross-sectional study. Methods Multiple wide-field three-dimensional SS-OCT scans (500×500A-scans over 12×12 mm 2 ) were obtained using a prototype instrument in 22 eyes of 22 healthy volunteers. A registration ...

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    2. Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia

      Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia

      The purpose of this study was to investigate changes in total retinal blood flow (RBF) using Doppler Fourier Domain Optical Coherence Tomography (Doppler FD‐OCT) in response to the manipulation of systemic partial pressure of CO 2 (P ET CO 2 ). Double circular Doppler blood flow scans were captured in nine healthy individuals (mean age ± standard deviation: 27.1 ± 4.1, six males) using the RTVue ™ FD‐OCT (Optovue). P ET CO 2 was manipulated using a custom‐designed computer‐controlled gas blender (RespirAct ™ ) connected to a sequential gas delivery rebreathing circuit. Doppler FD‐OCT measurements were captured at baseline ...

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    3. To Be or not TB?

      To Be or not TB?

      Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...

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    4. Diagnosing Macular Degeneration: The Tests that Tell

      Diagnosing Macular Degeneration: The Tests that Tell

      Perhaps you suddenly notice what seems like a constant ‘smudge’ in your central vision. Or maybe straight lines are beginning to seem wavy or distorted. Often, these are the initial symptoms of age-related macular degeneration . Since catching macular degeneration early is imperative in successfully treating the condition, it’s important to acknowledge these symptoms and have a doctor test you for macular degeneration as soon as possible. Through several different tests, physicians can determine if a patient is at risk for AMD, what stage of the disease a patient is at- and how to best stop the disease from progressing ...

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    5. Multi-Surface and Multi-Field Co-Segmentation of 3-D Retinal Optical Coherence Tomography

      Multi-Surface and Multi-Field Co-Segmentation of 3-D Retinal Optical Coherence Tomography

      When segmenting intraretinal layers from multiple optical coherence tomography (OCT) images forming a mosaic or a set of repeated scans, it is attractive to exploit the additional information from the overlapping areas rather than discarding it as redundant, especially in low contrast and noisy images. However, it is currently not clear how to effectively combine the multiple information sources available in the areas of overlap. In this paper, we propose a novel graphtheoretic method for multi-surface multi-field co-segmentation of intraretinal layers, assuring consistent segmentation of the fields across the overlapped areas. After 2D en-face alignment, all the fields are segmented ...

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    6. Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      A 41-year-old woman with skew deviation had cyclotorsion of both eyes. This resulted in a falsely low probability plot of retinal nerve fiber layer thickness in adjacent clock hours on optical coherence tomography (OCT) due to displacement of the retinal nerve fiber layer peaks. Ocular cyclotorsion may cause misinterpretation of OCT probability plots. OCT retinal nerve fiber layer plots also may be used to objectively quantify the degree of ocular cyclotorsion.

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      Mentions: Randy H. Kardon
    7. Optical coherence tomography-guided selective focal laser photocoagulation: a novel laser protocol for diabetic macular edema

      Optical coherence tomography-guided selective focal laser photocoagulation: a novel laser protocol for diabetic macular edema

      Background To compare the anatomic and functional results between optical coherence tomography (OCT)-guided selective focal laser photocoagulation (OCT–laser) and conventional modified Early Treatment Diabetic Retinopathy Study (mETDRS) laser treatment for diabetic macular edema (DME). Methods We analyzed treatment outcomes in 47 consecutive eyes treated with OCT–laser compared to 31 matched eyes treated with mETDRS. In the OCT–laser group, we identified ‘significant actively-leaking microaneurysms on OCT’ (SALMO) which are responsible for edema in OCT B-scan images, and thoroughly ablated them with photocoagulation. Best-corrected visual acuity (BCVA) and retinal thickness by OCT were compared at baseline and 12 ...

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    8. THE PEARL NECKLACE SIGN: A Novel Spectral Domain Optical Coherence Tomography Finding in Exudative Macular Disease

      THE PEARL NECKLACE SIGN: A Novel Spectral Domain Optical Coherence Tomography Finding in Exudative Macular Disease

      Purpose: To report a novel spectral domain optical coherence tomography finding in exudative macular disease, called the pearl necklace sign. Methods: A retrospective case series of 21 eyes (20 patients) with chronic exudative maculopathy resulting from age-related macular degeneration, diabetic macular edema, branch retinal vein occlusion, retinal arterial macroaneurysm, and Coats disease. Spectral domain optical coherence tomography images were carefully evaluated and correlated with color fundus photography, near-infrared reflectance, and fluorescein angiography. Results: A unique spectral domain optical coherence tomography macular finding of hyperreflective dots in a contiguous ring around the inner wall of cystoid spaces in the outer plexiform ...

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      Mentions: K. Bailey Freund
    9. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Purpose To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 patients with glaucoma were included. Methods One eye of each subject was scanned by a high-speed 1050-nm–wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used ...

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    10. Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography

      Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography

      Purpose We sought to assess the corneal thickness of the epithelium and stroma in keratoconic and normal eyes by spectral-domain optical coherence tomography (SD-OCT). Methods Fifty-seven keratoconic and 20 normal eyes were studied. The eyes were examined by SD-OCT, and the keratoconic eyes were subdivided into 2 groups: those showing only smooth corneal thinning and corneal protrusion on the image (KC1 group) and those showing abnormalities in the Bowman layer or in the stroma, or in both (KC2 group). The thicknesses at the corneal vertex and at the superior, inferior, nasal, and temporal cornea 1.5 mm from the corneal ...

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    11. University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for $188,364 for Computational Ophthalmology. The principal investigator is Linda Zangwill. The program began in 2014 and ends in 2014. Below is a summary of the proposed work. COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization ...

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    12. En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and In Vivo Confocal Microscopy

      En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and In Vivo Confocal Microscopy

      Purpose To explore the potential of spectral-domain optical coherence tomography (SD-OCT) using the en-face technology for the imaging of ocular surface diseases and to correlate the findings with in vivo confocal microscopy (IVCM) images. Patients and methods 113 eyes of 75 subjects with various ocular surface diseases were investigated with the RTVue ® anterior-segment en face OCT. En face OCT images were compared to B-scans OCT and IVCM images. Results: Patients with corneal dystrophies, corneal deposits, keratitis, pterygium, conjunctivochalasis, or ocular surface squamous neoplasia and patients who underwent lamellar corneal surgeries were included. En face OCT images showed ocular surface tissue ...

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    13. RETINOPATHY IN A PATIENT WITH ACUTE EPSTEIN-BARR VIRUS INFECTION: FOLLOW-UP ANALYSIS USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      RETINOPATHY IN A PATIENT WITH ACUTE EPSTEIN-BARR VIRUS INFECTION: FOLLOW-UP ANALYSIS USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To describe the clinical findings, diagnostics, and differential diagnosis in a patient with retinopathy in acute systemic Epstein-Barr virus (EBV) infection. Methods: Description of the clinical course of the EBV retinopathy was based on the medical record, photographs, and visual fields of the patient. Retinal morphology was visualized using spectral domain optical coherence tomography (Heidelberg Engineering), and fluorescein angiography. Multiple serologic tests were performed to exclude different infectious agents. A 30-year-old male patient presented with a focal scotoma in his right visual field. One week ago, he suffered from high fever, joint pain, neck stiffness, and hepatitis; 2 weeks ...

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    14. Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: A proof of concept

      Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: A proof of concept

      Purpose: External beam radiation therapy is currently considered the most common treatment modality for intraocular tumors. Localization of the tumor and efficient compensation of tumor misalignment with respect to the radiation beam are crucial. According to the state of the art procedure, localization of the target volume is indirectly performed by the invasive surgical implantation of radiopaque clips or is limited to positioning the head using stereoscopic radiographies. This work represents a proof-of-concept for direct and noninvasive tumor referencing based on anterior eye topography acquired using optical coherence tomography (OCT). Methods: A prototype of a head-mounted device has been developed ...

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    15. Diabetic macular oedema quantified with spectral-domain optical coherence tomography – evaluation of boundary line artefacts and the effect on retinal thickness

      Diabetic macular oedema quantified with spectral-domain optical coherence tomography – evaluation of boundary line artefacts and the effect on retinal thickness

      Purpose To characterize frequency, morphological cause and time-dependent change of boundary line artefacts in optical coherence tomography (OCT) examinations of centre-involved diabetic macular oedema (ciDME) patients who underwent ranibizumab treatment with 1-year follow-up and to evaluate the impact of artefacts on retinal thickness. Methods One hundred and fourteen patients were examined with radial scan protocol by Topcon 3D OCT at baseline, 3 and 12 months. All B scans from all visits were examined for boundary line artefacts (artefacts) and were stratified by morphological element causing artefacts including hard exudates (HE), epiretinal membranes (ERM), optical opacities and serous detachments. Boundary line ...

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    16. Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study

      Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study

      Purpose. The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. Methods. We reviewed spectral-domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. Retinal topographies were classified into several types, and the distribution and characteristics of each type were assessed in eyes with varying degrees of axial length (AL). Results. A total of 167 subjects with myopia were included in this study. Seventy eyes (41.9%) were classified as regular (R) type, 48 (28.7%) were wave (W ...

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      Mentions: Korea University
    17. sA population-based study of macular choroidal neovascularization using optical coherence tomography in Eastern China

      sA population-based study of macular choroidal neovascularization using optical coherence tomography in Eastern China

      The aim of the present study was to investigate the pathomorphological and functional variations of choroidal neovascularization (CNV) in age?related macular degeneration (AMD) in a Chinese population using optical coherence tomography (OCT). This population?based study enrolled 59 patients (age, >45 years; eyes, 70) with early and intermediate?stage AMD from Youyi Road Community, Baoshan District, Shanghai, China. Comprehensive standardized ophthalmic examinations included visual acuity, anterior segment analysis using a slit lamp, dilated fundus evaluation by direct ophthalmoscopy, 90D handheld lens analysis, fundus photography, fundus fluorescein angiography (FFA) and fast optic disk scans using OCT. The macular CNV characteristic ...

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    18. The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      Purposes: To assess the diagnostic performance of the macular parameters detected by spectral domain-optical coherence tomography (SD-OCT) in band atrophy (BA) eyes. Methods: Forty-nine BA eyes with permanent temporal hemianopia and 89 normal eyes were enrolled. Any patients who had nasal visual field loss were excluded. Each participant was imaged by 3D OCT-2000, and 10×10 grids in the macula were automatically allocated. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL)+ (GCL+inner plexiform layer (IPL)), and GCL++ thickness (RNFL+GCL+IPL) in both nasal and temporal hemiretina were calculated and compared between the ...

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    19. Swept-Source Optical Coherence Tomographic Findings of Choroidal Osteoma

      Swept-Source Optical Coherence Tomographic Findings of Choroidal Osteoma

      Purpose: To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF). Methods: Two eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF. Results: The location of the tumor was circumpapillary without macular involvement in case 1 and juxtapapillary with macular involvement in case 2. Both cases had a mixture of calcified and decalcified areas, and a concomitant choroidal neovascularization was found in case 2. The FAF images showed decreased autofluorescence in the central decalcified regions and relatively preserved fluorescence in marginal calcified regions in both cases ...

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    20. Assessment of the Optic Disc Morphology Using Spectral-Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

      Assessment of the Optic Disc Morphology Using Spectral-Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

      Objective . To compare the equivalent optic nerve head (OHN) parameters obtained with confocal scanning laser ophthalmoscopy (HRT3) and spectral-domain optical coherence tomography (OCT) in healthy and glaucoma patients. Methods . One hundred and eighty-two consecutive healthy subjects and 156 patients with open-angle glaucoma were divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent imaging of the ONH with the HRT3 and the Cirrus OCT. The ONH parameters and the receiver operating characteristic (ROC) curves were compared between both groups. Results . Mean age did not differ between the normal and glaucoma groups (59.55 ± 9.7 ...

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    21. Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements

      Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements

      Purpose To investigate grader learning effect and to quantify intergrader reproducibility of Doppler Spectral-Domain Optical Coherence Tomography (SD-OCT) derived retinal blood flow measurements. Methods Fifteen healthy young subjects (mean age 28.44; SD 3 years) underwent Doppler SD-OCT scans of one eye using the circumpapillary double circular scan protocol of the Optovue RTVue by one of two experienced operators. One trained (i.e. having undergone certification) and one novice (i.e. preliminary training comprising five standard practice data sets) individual then graded a standardized set of scans, consisting of 15 data sets (session 1) using custom Doppler Optical Coherence Tomography ...

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    22. OCT Imaging of a Traumatic Endothelial Ring

      OCT Imaging of a Traumatic Endothelial Ring

      Purpose: To report a case of a traumatic corneal endothelial ring sustained from a nonblast injury and its resolution with corneal optical coherence tomography (OCT) imaging. Methods: The authors present a report of the clinical case with imaging of the lesion using corneal OCT. Results: A 59-year-old man presented 1 day after sustaining a nonpenetrating foreign body injury to his cornea. Slit-lamp examination showed an endothelial annular lesion of 3.3 mm in diameter, which was grey-white in color. No other signs of traumatic injury were present. Stromal edema and endothelial disruption were demonstrated on corneal OCT. This resolved completely ...

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    23. Reference Standard Test and the Diagnostic Ability of Spectral Domain Optical Coherence Tomography in Glaucoma

      Reference Standard Test and the Diagnostic Ability of Spectral Domain Optical Coherence Tomography in Glaucoma

      Purpose: To evaluate the relationship between the reference standard used to diagnose glaucoma and the diagnostic ability of spectral domain optical coherence tomograph (SDOCT). Methods: In a cross-sectional study, 280 eyes of 175 consecutive subjects, referred to a tertiary eye care center for glaucoma evaluation, underwent optic disc photography, visual field (VF) examination, and SDOCT examination. The cohort was divided into glaucoma and control groups based on 3 reference standards for glaucoma diagnosis: first based on the optic disc classification (179 glaucoma and 101 control eyes), second on VF classification (glaucoma hemifield test outside normal limits and pattern SD with ...

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    24. Treatment decisions in diabetic macular edema based on optical coherence tomography retinal thickness map: LET classification

      Treatment decisions in diabetic macular edema based on optical coherence tomography retinal thickness map: LET classification

      Dear Editor, The approval of intravitreal injections of ranibizumab for the management of diabetic macular edema (DME) has induced a dramatical shift in the therapeutic approach of this entity, as the major clinical trials have proven the significant benefit of this treatment for patients with center-involving DME [ 1 – 3 ]. As a consequence, the classification of DME needs to be updated so that a useful correlation between grading and therapeutic indication could be assumed. Nowadays, the key feature of DME is the involvement or sparing of the fovea. Whenever DME involves the fovea, a clear indication for treatment with ranibizumab seems ...

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