1. Articles in category: Ophthalmology

    553-576 of 8735 « 1 2 ... 21 22 23 24 25 26 27 ... 362 363 364 »
    1. Image Processing Research Fellow/Programmer Position at Doheny Eye Institute

      Image Processing Research Fellow/Programmer Position at Doheny Eye Institute

      RESEARCH FIELDS: Ophthalmic image segmentation in unimodal and multimodal images RESEARCH LABORATORY: Doheny Image Analysis Laboratory (DIAL) at Doheny Eye Institute, University of California, Los Angeles ACTIVITY: DIAL is a rapidly growing and interdisciplinary group to investigate new approaches for image segmentation, registration, visualization, and analysis in various multimodal ophthalmic images at Doheny Eye Institute, standing among the top recipients of medical research grants from the National Institutes of Health, which fund 80% of all vision research in America. We are particularly interested in the development of various novel image segmentation and registration algorithms and the translation of the development ...

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    2. In Vivo Choroidal Vascular Lesions in Diabetes on Swept-Source Optical Coherence Tomography

      In Vivo Choroidal Vascular Lesions in Diabetes on Swept-Source Optical Coherence Tomography

      Diabetes induces microvascular diseases including diabetic retinopathy and choroidopathy which reciprocally promote the pathogenesis, although optical coherence tomography images of diabetic choroidopathy remains to be documented. Here we evaluated the qualitative characteristics of choroidal vascular lesions in patients with diabetes and their association with diabetic retinopathy on swept-source optical coherence tomography (SS-OCT) images. We retrospectively reviewed 110 consecutive eyes of 110 patients with diabetes and 35 eyes of 35 healthy subjects for whom SS-OCT images (6x6-mm scans centered on the fovea) of sufficient quality were acquired. The curve of chorioretinal sections was flattened using Bruch’s membrane as a reference ...

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    3. Handheld device takes high-resolution images of children's retinas

      Handheld device takes high-resolution images of children's retinas

      Engineers and physicians at Duke University have developed a handheld device capable of capturing images of a retina with cellular resolution. The new probe will allow researchers to gather detailed structural information about the eyes of infants and toddlers for the first time. "Diagnostic tools that examine and image the retina have been well-designed for adults, but are exceedingly difficult to use in infants and young children who can't hold the required position or focus for long enough periods of time," said Cynthia Toth, professor of ophthalmology and biomedical engineering at Duke University. "Before now, it hasn't been ...

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    4. Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Purpose To investigate agreement between the IOLMaster 700 based on swept-source optical coherence tomography (SS-OCT) and the Lenstar LS 900 based on optical low-coherence reflectometry (OLCR). Setting Private practice, Castrop-Rouxelle, Germany. Design Prospective evaluation of diagnostic test. Methods Axial length (AL), keratometry (K), anterior chamber depth (corneal epithelium to lens) (ACD), lens thickness, and central corneal thickness (CCT) were measured in 183 eyes of 183 patients. Analyses used a paired t test, Pearson correlation coefficient ( r ), and Bland-Altman plots. Intraocular lens (IOL) power calculations were compared using the Hoffer Q, Holladay 1, and SRK/T formulas. Results The difference in ...

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      Mentions: Giacomo Savini UCLA
    5. Macular segmentation via optical coherence tomography in pediatric optic nerve head drusen and mild papilledema

      Macular segmentation via optical coherence tomography in pediatric optic nerve head drusen and mild papilledema

      Optic nerve head drusen (ONHD) and papilledema in children can lead to partial optic atrophy, and frequently children with idiopathic intracranial hypertension may have both. The purpose of this study is to use SD-OCT to identify possible subclinical atrophy of the inner macula in eyes of children with pseudopapilledema due to ONHD and mild papilledema.

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    6. Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema

      Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema

      New Spectralis (Heidelberg, Germany) segmentation software allows automatic quantitation of the thickness of each macular layer. We evaluated the role of Spectralis spectral domain optical coherence tomography (SD-OCT) segmentation in children during acute papilledema to predict the subsequent development of optic atrophy.

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    7. Spectral domain optical coherence tomography (SD-OCT) Imaging of the Vascular-Avascular junction in the nursery in infants with retinopathy of prematurity

      Spectral domain optical coherence tomography (SD-OCT) Imaging of the Vascular-Avascular junction in the nursery in infants with retinopathy of prematurity

      Since the publication of Foos, there has been little additional microanatomic data on the vascular-avascular junction in retinopathy of prematurity (ROP) in infants. We hypothesize that one could view retinal development across the vascular-avascular (V-AV) junction in infants with ROP using portable bedside SDOCT imaging and novel image analysis.

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    8. Change of retinal pigment epithelial atrophy after anti-vascular endothelial growth factor treatment in exudative age-related macular degeneration

      Change of retinal pigment epithelial atrophy after anti-vascular endothelial growth factor treatment in exudative age-related macular degeneration

      Purpose: The study aimed to investigate the quantitative changes of retinal pigment epithelial (RPE) atrophy during a 24-month follow-up period of anti-vascular endothelial growth factor (VEGF) for exudative age-related macular degeneration (AMD). Materials and Methods: This is a retrospective study. Sixty-five eyes of 62 consecutive patients with naοve exudative AMD who had received treatment with anti-VEGF therapy and followed for more 24 months were enrolled. All patients received three initial monthly injections of anti-VEGF (ranibizumab or bevacizumab), followed by pro re nata or treat-and-extend protocol. Color fundus image, optical coherence tomography, and fundus autofluorescence were evaluated for RPE atrophy ...

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    9. Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. (OCT)

      Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. (OCT)

      The primary aim of the study is to investigate whether optical coherence tomography (OCT) may be a useful tool for investigating the in-vivo histology of ocular structures in patients with tear film pathology. In epiphora the investigators will image the proximal lacrimal system. In dry eye syndrome the investigators will image the lacrimal gland and also the buccal mucosa. The secondary aim of the study is to investigate the appearance of the normal cornea and conjunctiva under OCT imaging.

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    10. Optical coherence tomography characteristics of different types of big bubbles seen in deep anterior lamellar keratoplasty by the big bubble technique

      Optical coherence tomography characteristics of different types of big bubbles seen in deep anterior lamellar keratoplasty by the big bubble technique

      Purpose To define optical coherence tomography (OCT) characteristics of type-1, type-2, and mixed big bubbles (BB) seen in deep anterior lamellar keratoplasty. Methods Human sclero-corneal discs were obtained from UK (30) and Canada (16) eye banks. Air was injected into corneal stroma until a BB formed. UK samples were fixed in formalin before scanning with Fourier-domain (FD-OCT). One pair of each type of BB was scanned fresh. All BB obtained from Canada were scanned fresh with time-domain (TD-OCT). For each OCT machine used, type-1 BB from which Descemets membrane (DM) was partially peeled, were also scanned. The morphological characteristics of ...

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    11. Scheimpflug and Optical Coherence Tomography Analysis of Posterior Keratoconus

      Scheimpflug and Optical Coherence Tomography Analysis of Posterior Keratoconus

      Purpose: To report a case series of 7 eyes of 6 patients with posterior keratoconus, evaluating corneal Scheimpflug tomographic changes and anterior-segment optical coherence tomography (OCT). Methods: In our descriptive study, 6 patients were diagnosed with posterior keratoconus: 5 unilateral (7-, 33-, and 42-year-old males and 64- and 60-year-old female) and 1 bilateral (45-year-old female). Patients were diagnosed with slit-lamp examination, which revealed corneal opacity with an underlying posterior corneal depression. Additional analysis with anterior-segment OCT and Scheimpflug tomography evaluation was performed. Results: Localized paracentral posterior keratoconus was diagnosed in 7 eyes. Scheimpflug images demonstrated posterior corneal depression. Clinical findings ...

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    12. Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Blood flow changes are highly related to neural activities in the retina. It has been reported that neural activity increases when flickering light stimulation of the retina is used. It is known that blood flow changes with flickering light stimulation can be altered in patients with vascular disease and that measurement of flicker-induced vasodilatation is an easily applied tool for monitoring functional microvascular alterations. However, details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood due to the limitation of existing techniques. In this study, flickering light stimulation was applied to mouse retinas to ...

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      Mentions: Xincheng Yao
    13. Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression

      Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression

      Purpose : We assessed the application of the choroidal vascularity index (CVI) in the follow-up of Vogt-Koyanagi-Harada disease (VKH) patients derived from image binarization of enhanced depth imaging optical coherence tomography (EDI-OCT) images with Fiji software. Our secondary objective was to derive the retinochoroidal vascularity index based on en face fundus fluorescein and indocyanine green angiography (FFA and ICGA). Methods : In this retrospective cohort study, EDI-OCT scans of 18 eyes of 9 patients with VKH were obtained at baseline within 2 weeks of acute presentation, and again at 6 to 12 months. Images with poor quality were excluded. Choroidal thickness (CT ...

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    14. Volumetric Image Classification using Homogeneous Decomposition and Dictionary Learning: A Study Using Retinal Optical Coherence Tomography for Detecting Age-related Macular Degeneration

      Volumetric Image Classification using Homogeneous Decomposition and Dictionary Learning: A Study Using Retinal Optical Coherence Tomography for Detecting Age-related Macular Degeneration

      Three-Dimensional (3D) (volumetric) diagnostic imaging techniques are indispensable with respect to the diagnosis and management of many medical conditions. However there is a lack of automated diagnosis techniques to facilitate such 3D image analysis (although some support tools do exist). This paper proposes a novel framework for volumetric medical image classification founded on homogeneous decomposition and dictionary learning. In the proposed framework each image (volume) is recursively decomposed until homogeneous regions are arrived at. Each region is represented using a Histogram of Oriented Gradients (HOG) which is transformed into a set of feature vectors. The Gaussian Mixture Model (GMM) is ...

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    15. Post-Mortem Corneal Thickness Measurements with a Portable Optical Coherence Tomography System: a Reliability Study

      Post-Mortem Corneal Thickness Measurements with a Portable Optical Coherence Tomography System: a Reliability Study

      The purpose of this study was to determine the repeatability and reproducibility of post-mortem central corneal thickness (CCT) measurements by using a real-time, portable optical coherence tomography (OCT) system on an animal model, and to prospectively evaluate the time-course of post-mortem changes in CCT. Forty-six ocular globes of sheep ( Ovis aries ) were analyzed with a portable spectral-domain OCT device by two operators at different postmortem intervals (PMIs) as follows: immediately (i.e. within 10 minutes), at the 30 th minute, at the 1 st , 6 th , 12 th , 24 th and 48 th hour, and later (up to the 96 ...

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    16. Retinal nerve fiber and optic disc morphology using spectral-domain optical coherence tomography in scleroderma patients

      Retinal nerve fiber and optic disc morphology using spectral-domain optical coherence tomography in scleroderma patients

      To evaluate the optic nerve head parameters and peripapillary retinal nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in a systemic sclerosis (SSc) cohort and age-matched controls to determine whether SSc patients have an increased risk of normal-tension glaucoma (NTG). We examined 30 patients (3 male, 27 female) with SSc and 28 age- and sex-matched controls. Retinal nerve fiber and optic disc morphology were evaluated using Cirrus SD-OCT. Optic disc morphology measurements including disc area, rim area, average and vertical cup/disc (C/D) ratio, and cup volume were not significantly different between the study groups. The average and ...

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    17. Optical coherence tomography imaging of optic disc cavernous haemangioma

      Optical coherence tomography imaging of optic disc cavernous haemangioma

      Optic disc cavernous haemangiomas are either found incidentally or after presentation with vitreous haemorrhage. They are characterised by a cluster of grapes appearance to the multiple vascular saccules that make up the tumour. They are more often found in the retinal periphery but rarely occur at the optic disc. Optical coherence tomography (OCT) imaging may be a useful non-invasive imaging modality to follow-up these lesions. We present the case of an asymptomatic 60-year-old lady referred from her optometrist with a lesion overlying the optic disc and the ensuing diagnosis of cavernous haemangioma using fundus fluorescein angiography and OCT.

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    18. Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography

      Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography

      Purpose : We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA). Methods : A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images of these patients were compared to those from indocyanine green angiography (ICGA). Semiautomated segmentation was used to further analyze the polypoidal lesion and the BVN. Results : We studied 13 eyes of ...

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    19. Role of Tractional Forces and Internal Limiting Membrane in Macular Hole Formation: Insights from Intraoperative Optical Coherence Tomography

      Role of Tractional Forces and Internal Limiting Membrane in Macular Hole Formation: Insights from Intraoperative Optical Coherence Tomography

      We report the case of a 69-year-old patient who underwent vitrectomy for vitreomacular traction (VMT) and developed a postoperative macular hole that was observed 1 week after surgery. The hole did not close by in-office fluid-gas exchange alone, but was achieved after repeat surgery with internal limiting membrane (ILM) peeling. Intraoperative OCT (iOCT) images from the first surgery revealed an occult macular hole that formed after VMT release. We discuss how iOCT findings provide insight into the role of the ILM in macular hole formation and emphasize the importance of carefully inspecting iOCT images in real time to avoid missing ...

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      Mentions: UC Davis
    20. Swept-Source Optical Coherence Tomography Detecting Intraoperative Acute Descemet's Fold Formation

      Swept-Source Optical Coherence Tomography Detecting Intraoperative Acute Descemet's Fold Formation

      Background: To present an intraoperative acute Descemet’s fold formation using swept-source optical coherence tomography (SS-OCT) imaging. Case Report: A 67-year-old man complaining of reduced visual acuity in the left eye. A 25-gauge pars plana vitrectomy combined with phacoemulsification cataract surgery was performed to remove the vitreomacular traction. When hydro-sealing was performed, striae rapidly spread in the cornea. SS-OCT B-scan images performed on postoperative day 1 revealed a wavy Descemet’s membrane that might correspond to Descemet’s folds. Pairs of hypo- and hyperreflective narrow lesions running from the wavy Descemet’s membrane to almost half of the thickness of ...

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    21. Correlation between central foveal thickness as measured by OCT andHbA1c level in diabetes retinopathy

      Correlation between central foveal thickness as measured by OCT andHbA1c level in diabetes retinopathy

      bjectives: To evaluate the correlation between Glycosylated Haemoglobin (HbA1c) level and central foveal thickness measured by Optical coherence tomography (OCT) in patients with type 2 diabetes mellitus.Materials and methods:This was a retrospective single center study of 6 month duration including patients of pre-proliferative stage of type 2 diabetes mellitus. Clinically significant macular oedema (CSME) was diagnosed by using OCT. OCT examination by ‘RT optovue, Fremont, CA’ and HbA1c measured by specific high-pressure liquid chromatography methods. If patient have both eye macular oedema, eye with thicker macular oedema was used for statistical analysis. Exclusion of patients who received intraocular ...

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      Mentions: Optovue
    22. Minification of fundus optical coherence tomographic images in gas-filled eye

      Minification of fundus optical coherence tomographic images in gas-filled eye

      Background Optical coherence tomography (OCT) is being used increasingly to evaluate and manage a variety of retinal diseases, but not much is known about the minification of the OCT images in gas-filled eyes. The purpose of this study was to investigate the effect of gas-filled eyes on the size of the OCT images. Methods This was retrospective case series of 81 consecutive eyes of 79 patients who had macular hole surgery between April 2012 and September 2014. Images of the optic disc were taken with a spectral domain-OCT instrument 2 days after surgery in gas-filled, pseudophakic eyes and from the ...

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    23. Assessment of Optic Pathway Structure and Function in Patients With Compression of the Optic Chiasm: A Correlation With Optical Coherence Tomography

      Assessment of Optic Pathway Structure and Function in Patients With Compression of the Optic Chiasm: A Correlation With Optical Coherence Tomography

      Purpose : The purpose of this study was to investigate correlations between retinal fiber thickness measured by optical coherence tomography (OCT) and anterograde functional and structural differences in the optic pathway of patients with compression of the optic chiasm. Our hypothesis was that loss of visual acuity caused by chronic compressive pathologies may lead to an irreversible decline in vision because of permanent neurodegeneration of the optic radiations and visual cortex. Methods : Quantitative OCT, functional magnetic resonance imaging (MRI) and diffusion tensor MRI measurements were made in 17 patients being surgically treated for chiasmal compression. Results : In our study we found ...

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