1. Articles in category: Ophthalmology

    553-576 of 8259 « 1 2 ... 21 22 23 24 25 26 27 ... 343 344 345 »
    1. Semiautomated SD-OCT Measurements of Corneal Sublayer Thickness in Normal and Post-SMILE Eyes

      Semiautomated SD-OCT Measurements of Corneal Sublayer Thickness in Normal and Post-SMILE Eyes

      Purpose: To test the reliability of a novel algorithm for measuring corneal epithelial thickness (ET) and stromal thickness of normal eyes and post-small incision lenticule extraction (SMILE) corneas with spectral-domain optical coherence tomography. Methods: In this prospective observational study, a customized semiautomated software algorithm was developed and applied to measure corneal ET and stromal thickness along the horizontal corneal meridian. Measurements were performed by 2 examiners in a randomized fashion on a sample of 40 eyes with previous SMILE for treatment of myopia and a control group composed of 40 normal eyes. The intrauser repeatability and interuser reproducibility were analyzed ...

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    2. Spectral domain optical coherence tomography imaging of subretinal bands associated with ...

      Spectral domain optical coherence tomography imaging of subretinal bands associated with ...

      We report three patients with subretinal bands associated with retinal detachment in chronic retinal detachments who underwent successful retinal reattachment. Subretinal bands before and after surgery can be identified on clinical examination and spectral domain optical coherence tomography. Removal of subretinal bands is not mandatory to achieve retinal reattachment

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    3. Automated volumetric segmentation of retinal fluid on optical coherence tomography

      Automated volumetric segmentation of retinal fluid on optical coherence tomography

      We propose a novel automated volumetric segmentation method to detect and quantify retinal fluid on optical coherence tomography (OCT). The fuzzy level set method was introduced for identifying the boundaries of fluid filled regions on B-scans (x and y-axes) and C-scans (z-axis). The boundaries identified from three types of scans were combined to generate a comprehensive volumetric segmentation of retinal fluid. Then, artefactual fluid regions were removed using morphological characteristics and by identifying vascular shadowing with OCT angiography obtained from the same scan. The accuracy of retinal fluid detection and quantification was evaluated on 10 eyes with diabetic macular edema ...

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    4. Optical Coherence Tomography in Neurologic Disease (Textbook)

      Optical Coherence Tomography in Neurologic Disease (Textbook)

      Shortly after the invention of the first two-dimensional optical coherence tomography (OCT) scans by James Fujimoto and colleagues at the Massachusetts Institute of Technology in 1991, ophthalmologists recognized the extraordinary potential for OCT to facilitate quantitative assessment of the neuroretina. OCT rapidly became a commonplace tool in ophthalmologic practice to identify both inflammatory and degenerative conditions affecting the optic nerve and retina. The utility of OCT to detect and quantify sequelae of optic neuropathies, including glaucoma and those associated with primary neurological diseases , was soon brought to the forefront. Rapid advances in the technology have followed and have included faster ...

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    5. Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes with Branch Retinal Vein Occlusion

      Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes with Branch Retinal Vein Occlusion

      Purpose To measure the vascular density and foveal avascular zone (FAZ) area in the deep and superficial retinal vascular networks using optical coherence tomography angiography (OCTA) in patients with branch retinal vein occlusion (BRVO). Design Retrospective observational case series. Methods Patients with unilateral BRVO involving the macula were enrolled. OCTA (RTVue-XR Avanti, Optovue) was performed on the BRVO and fellow eyes. Macular vascular density, FAZ area, and foveal thickness were measured in all eyes. Results Seventeen eyes of 17 patients met inclusion criteria. The mean overall vascular density measured in the entire scan was lower in BRVO eyes compared to ...

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      Mentions: Optovue
    6. Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence Tomography Imaging in Patients with a History of Retinopathy of Prematurity

      Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence Tomography Imaging in Patients with a History of Retinopathy of Prematurity

      Purpose To evaluate retinal anatomy and segmentation errors from spectral domain optical coherence tomography (SD-OCT) imaging (MM5 protocol of RTVue-100; Optovue, Inc., Fremont, CA) in school-aged children. Design A prospective cohort study in a referral medical center. Methods 133 eyes of 133 patients were enrolled. Patients were grouped as those who were treated for retinopathy of prematurity (ROP) (ROP-Tx-group); those with spontaneously-regressed ROP (ROP-non-Tx-group); other premature patients (premature group); and full-term age-matched children (full-term group). Anatomy and segmentation errors of retina were evaluated by SD-OCT. Results The mean age at assessment was 9.5 years (range 4–16 years). The ...

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      Mentions: Optovue Yen Po Chen
    7. Rowe Technical Design, Inc. announces that cataract pathologies are now available in the Whole and Anterior Chamber Model Eye Tissue Phantom!

      Rowe Technical Design, Inc. announces that cataract pathologies are now available in the Whole and Anterior Chamber Model Eye Tissue Phantom!

      Rowe Technical Design, Inc. (RTD), developers of the 1st commercial optical tissue phantom for OCT, announces that cataract pathology (nuclear and sub capsular) is now an option for the Whole Model Eye and Anterior Chamber Model Eyes. “We’re excited because this is our first pathology option for a production model eye, following up on the very successful Whole and Anterior Chamber Model Eyes with normal morphology tissue phantoms” notes T. Scott Rowe, company founder and president. “We are pleased with the customer feedback so far, and we are readying this for production as an option. This is the first ...

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      Mentions: T. Scott Rowe
    8. Epiretinal membrane: optical coherence tomography-based diagnosis and classification

      Epiretinal membrane: optical coherence tomography-based diagnosis and classification

      Epiretinal membrane (ERM) is a disorder of the vitreomacular interface characterized by symptoms of decreased visual acuity and metamorphopsia. The diagnosis and classification of ERM has traditionally been based on clinical examination findings. However, modern optical coherence tomography (OCT) has proven to be more sensitive than clinical examination for the diagnosis of ERM. Furthermore, OCT-derived findings, such as central foveal thickness and inner segment ellipsoid band integrity, have shown clinical relevance in the setting of ERM. To date, no OCT-based ERM classification scheme has been widely accepted for use in clinical practice and investigation. Herein, we review the pathogenesis, diagnosis ...

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    9. Non-invasive assessment of corneal and conjunctival deterioration in soft contact lens users using anterior segment optical coherence tomography

      Non-invasive assessment of corneal and conjunctival deterioration in soft contact lens users using anterior segment optical coherence tomography

      Background The aim was to evaluate the corneal and bulbar conjunctival thicknesses of soft contact lens (SCL) wearers using anterior segment optical coherence tomography (AS-OCT). Methods The epithelial and overall thicknesses of both the central cornea and the infero-temporal bulbar conjunctiva of SCL wearers (30 subjects) were obtained by Cirrus HD-OCT and compared with those of refraction-matched controls (30 subjects) and patients with emmetropia (30 subjects). Results The mean corneal epithelial thicknesses in SCL wearing, spectacle-wearing and emmetropic groups were 48.97 ± 5.45, 52.18 ± 4.84 and 53.18 ± 5.05 µm, respectively. The corneal epithelium of members ...

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    10. OCT Angiography in Retinal and Macular Diseases (Textbook)

      OCT Angiography in Retinal and Macular Diseases (Textbook)

      In only a short period of time, the innovative procedure of OCT angiography has become an essential macula imaging technique. Now that it is routinely used in clinical practice, the investigation of retinal and choroidal circulation is noninvasive, which significantly changes the professional’s approach to patients. In this volume, retina specialists and renowned experts share their experience with OCT angiography. They have included numerous color images and presented current ideas to form a base for further research and discussion. This book provides retina specialists, ophthalmologists, and researchers with a first glance at original research and clinical reports on this ...

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    11. Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography

      Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography

      Purpose To screen for subclinical keratoconus by analyzing corneal, epithelial, and stromal thickness map patterns with Fourier-domain optical coherence tomography (OCT). Setting Four centers in the United States. Design Cross-sectional observational study. Methods Eyes of normal subjects, subclinical keratoconus eyes, and the topographically normal eye of a unilateral keratoconus patient were studied. Corneas were scanned using a 26 000 Hz Fourier-domain OCT system (RTVue). Normal subjects were divided into training and evaluation groups. Corneal, epithelial, and stromal thickness maps and derived diagnostic indices, including pattern standard deviation (PSD) variables and pachymetric map–based keratoconus risk scores, were calculated from the ...

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    12. Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

      Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

      Background: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. En face OMAG images for preLC were generated using signals with highest blood ...

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    13. Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

      Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

      Optical Coherence Tomography (OCT) is a non-invasive 3 dimensional optical imaging modality that enables high resolution cross sectional imaging in biological tissues and materials. Its high axial and lateral resolution combined with high sensitivity, imaging depth and wide field of view makes it suitable for wide variety of high resolution medical imaging applications at clinically relevant speed. With the advent of swept source lasers, the imaging speed of OCT has increased considerably in recent years. OCT has been used in ophthalmology to study dynamic changes occurring in the cornea and iris, thereby providing physiological and pathological changes that occur within ...

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    14. Evaluation of Macular Ganglion Cell-inner Plexiform Layer and Choroid in Psoriasis Patients Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography

      Evaluation of Macular Ganglion Cell-inner Plexiform Layer and Choroid in Psoriasis Patients Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography

      Purpose : To evaluate changes in the thickness of the central macula, macular ganglion cell-inner plexiform layer (mGCIPL), and subfoveal choroid in patients with psoriasis using spectral domain optical coherence tomography (SD-OCT). Methods : The measurements of macular, mGCIPL thicknesses and subfoveal choroidal thickness (SFCT) obtained by SD-OCT of psoriasis patients ( n = 46). These measurements were compared with those of 50 healthy controls. Results : The macular, mGCIPL, and choroidal thicknesses did not differ between the controls and psoriatic subjects ( p >0.05). When the patients were divided into two distinct groups, only the SFCT was significantly thicker in the severe psoriasis group ...

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    15. In Vivo Assessment of Choroid in Diabetic Retinopathy by Enhanced Depth Imaging in Spectral Domain Optical Coherence Tomography

      In Vivo Assessment of Choroid in Diabetic Retinopathy by Enhanced Depth Imaging in Spectral Domain Optical Coherence Tomography

      Purpose: The aim of this study was to measure the largest hyporeflective (LHR) lumen in the choroid and subfoveal choroidal thickness (SFCT) in patients with diabetic retinopathy (DR) and in control subjects using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Design: This was a prospective, cross-sectional study. Methods: This was a study of 240 eyes of DR patients (n = 120) and control subjects (n = 120) matched for age, sex, and refractive error. The LHR lumens of the choroidal vessels and SFCT were measured by EDI SD-OCT. Further intergroup classification into nonproliferative and proliferative DR, with or without ...

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    16. Comparison of Peripapillary Choroidal Thickness Measurements via Spectral Domain Optical Coherence Tomography with and without Enhanced Depth Imaging

      Comparison of Peripapillary Choroidal Thickness Measurements via Spectral Domain Optical Coherence Tomography with and without Enhanced Depth Imaging

      Objectives : To compare peripapillary choroidal thickness (PP-CT) measurements using a spectral domain optical coherence tomography (SD-OCT) device with and without enhanced depth imaging (EDI). Methods : Sixty healthy subjects aged from 18 to 40 years were included in this study. PP-CTs were measured in the right eyes by manual segmentation via SD-OCT both with and without EDI. The intraclass correlation coefficient (ICC) for each technique and comparison of PP-CT measurements between two techniques were evaluated. The correlation between retinal nerve fiber layer (RNFL) thickness and PP-CT was also explored on images of SD-OCT without EDI. Results : The PP-CT measurements of 55 ...

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    17. Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy

      Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy

      Purpose To report the swept-source optical coherence tomography angiography (SS-OCTA) findings after bevacizumab anti-vascular endothelial growth factor (anti-VEGF) and full-fluence photodynamic therapy (PDT) for choroidal neovascularization. Design Case report. Methods An 87-year-old, Chinese male presented with a shadow and decreased vision to 20/160 in his left eye (OS). Clinical examination, color photographs, swept-source optical coherence tomography (SS-OCT), widefield dye-fluorescein angiography (FA) and SS-OCTA revealed an extrafoveal, subretinal choroidal neovascularization (CNV) in the superior macula. Bevacizumab anti-VEGF and full-fluence PDT was initiated. Results Initial imaging with conventional color photography and FA demonstrated a classic CNV with significant early hyperfluorescence and ...

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    18. Optical coherence tomography in multiple sclerosis

      Optical coherence tomography in multiple sclerosis

      In patients with multiple sclerosis, thinner peripapillary retinal nerve fibre layers (pRNFL) and retinal ganglion cell layers in eyes without previous optic neuritis, as measured with optical coherence tomography (OCT), have been associated with global brain atrophy and disability. Although most of the data so far have been obtained in cross-sectional studies, the idea to use OCT parameters as surrogate markers of neuroaxonal degeneration and multiple sclerosis disability has been put forth by Elena Martinez-Lapiscina and colleagues 1 in The Lancet Neurology .

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    19. Fundus autofluorescence and optical coherence tomography of a macular cherry-red spot in a case report of sialidosis

      Fundus autofluorescence and optical coherence tomography of a macular cherry-red spot in a case report of sialidosis

      Background Sialidosis is a rare lysosomal storage disorder characterized by deficiency of alpha-N-acetyl neuraminidase. The macular cherry-red spot, which could be important for diagnosis, is a distinctive feature of its ocular manifestation. We evaluated the fundus autofluorescence (FAF) and optical coherence tomography (OCT) images of a juvenile patient who presented with vision decrease and was later confirmed with genetic sialidosis. Case presentation A 13-year-old Chinese male presented with bilateral decreased vision over the past 2 years before his initial visit. Funduscopic examination revealed a macular cherry-red bilateral spot. FAF showed hyperreflective areas surrounding a central hyporeflective fovea in both eyes ...

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      Mentions: Fudan University
    20. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the CLN3 gene. Conclusion: In these rare cases of juvenile neuronal ceroid lipofuscinosis, optical coherence tomography enabled unambiguous detection of prominent morphologic abnormalities of the retina at the patient's first ...

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    21. Three-dimensional image reconstruction of macula from stratus optical coherence tomography (OCT) fordiagnosis of macular degeneration

      Three-dimensional image reconstruction of macula from stratus optical coherence tomography (OCT) fordiagnosis of macular degeneration

      Diagnosis of macular degeneration using a Stratus OCT with a fast macular thickness map (FMTM) method produced six B-scan images of macula from different angles. The images were converted into a retinal thickness chart to be evaluated by normal distribution percentile of data so that it can be classified as normal thickness of macula or as experiencing abnormality (e.g. thickening and thinning). Unfortunately, the diagnostic images only represent the retinal thickness in several areas of the macular region. Thus, this study is aims to obtain the entire retinal thickness in the macula area from Status OCT's output images ...

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    22. The retinal nerve fiber layer, choroidal thickness, and central macular thickness in morbid obesity: an evaluation using spectral-domain optical coherence tomography

      The retinal nerve fiber layer, choroidal thickness, and central macular thickness in morbid obesity: an evaluation using spectral-domain optical coherence tomography

      OBJECTIVE: To assess the effect of morbid obesity on retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), retinal ganglion cell (RGC), choroidal thickness (CT), central corneal thickness (CCT), and intraocular pressure (IOP). PATIENTS AND METHODS: Sixty-seven patients defined as having morbid or class III obesity (BMI ≥ 40; Group 1) scheduled to undergo sleeve gastrectomy surgery and 29 nonobese patients (BMI 18.50-24.99; Group 2) underwent complete ophthalmic examination for measurement of IOP, CT, RNFL thickness, CMT, RGC, and CCT. RNFL thickness, CMT, and RGC were measured using spectral-domain optical coherence tomography (SD-OCT). CT measurement was performed using ...

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    23. Spectral-Domain Optical Coherence Tomography as a Potential Biomarker in Huntington's Disease

      Spectral-Domain Optical Coherence Tomography as a Potential Biomarker in Huntington's Disease

      Background Spectral-domain optical coherence tomography has been used in several neurological conditions, and peripapillary and macular measurements have been proposed as potential biomarkers in these disorders. The aim of this study was to investigate retinal and choroidal changes in Huntington's disease and to evaluate any potential correlation with the stage of the disease. Methods A cross-sectional observational study compared patients with Huntington's disease and controls. Patients were evaluated using the Unified Huntington's Disease Rating Scale. Spectral-domain optical coherence tomography with enhanced depth imaging was used, and peripapillary choroidal and retinal nerve fiber layer thickness and macular retinal ...

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    24. Optical Coherence Tomography: An Adjunctive Tool for Differentiating between Choroidal Melanoma and Metastasis

      Optical Coherence Tomography: An Adjunctive Tool for Differentiating between Choroidal Melanoma and Metastasis

      Purpose. To investigate the value of optical coherence tomography (OCT) for differentiation between choroidal melanoma and metastasis based on characteristics of the anterior choroidal surface and the chorioretinal interface. Methods. This retrospective observational case series included 29 patients with untreated choroidal melanomas and 21 patients with untreated choroidal metastases. Regularity and lobularity characteristics of the anterior choroidal surface were evaluated in a masked manner. Retinal and retinal pigment epithelium (RPE) findings were documented as well. Results. OCT demonstrated a regular and smooth anterior choroidal surface in 89.7% of the eyes with melanoma and in 47.6% of the eyes ...

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