1. Articles in category: Ophthalmology

    553-576 of 7905 « 1 2 ... 21 22 23 24 25 26 27 ... 328 329 330 »
    1. Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy

      Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy

      Purpose To analyse structural changes in conjunctiva, sclera and Schlemm's canal (SC) following canaloplasty with optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Methods Fifteen patients undergoing canaloplasty were included in this prospective study. AS-OCT images were acquired pre- and 1, 7, 30 and 90 days postoperatively. UBM was performed 3 months postoperatively. The surgical site was evaluated for the presence of SC, transscleral filtration, a scleral lake and the visibility of intra-Schlemm-sutures. The height and width of SC were measured at the 3 and 9 o'clock limbus position. Results After canaloplasty, SC was detectable with AS-OCT in ...

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    2. Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses

      Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses

      Purpose : To assess the extent to which glaucomatous damage of the macula can be detected using the summary statistics of a commercial report based upon the circumpapillary retinal nerve fiber layer (cpRNFL) thickness obtained with frequency domain optical coherence tomography (fdOCT). Methods : One hundred forty-three eyes of 143 open-angle glaucoma patients and suspects (56.4 ± 13.8 years) had 10-2 visual fields (VFs) and fdOCT macular and disc cube scans. RNFL and retinal ganglion cell plus inner plexiform layer thickness and probability maps were generated and combined with 10-2 VF information in a single-page, custom report previously described. Three graders ...

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    3. ARVO to host Imaging in the Eye Conference in May

      ARVO to host Imaging in the Eye Conference in May

      The Association for Research in Vision and Ophthalmology (ARVO) will be hosting its annual Imaging in the Eye Conference on Saturday, April 30, 2016 in Seattle, Wash. This one-day conference takes place the day before the ARVO Annual Meeting. The conference brings together leading basic researchers, clinicians and engineers in the ophthalmic imaging field. Attendees can meet colleagues who are specialists in technology development, small animal imaging, image processing, translational research, clinical studies and clinical care in this rapidly changing area of research. The Imaging Conference highlights advances in many imaging techniques including optical coherence tomography (OCT), adaptive optics (AO ...

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    4. University of Southern California Receives NIH Grant for High Resolution Elastography of Retina Under Prosthetic Electrical Stimulation

      University of Southern California Receives NIH Grant for High Resolution Elastography of Retina Under Prosthetic Electrical Stimulation

      University of Southern California Receives a 2015 NIH Grant for $561,173 for High Resolution Elastography of Retina Under Prosthetic Electrical Stimulation. The principal investigator is Qifa Zhou. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Visual prostheses based on electrical stimulation of the retina are an effective approach for treating blindness in individuals with photoreceptor degenerative diseases (e.g., retinitis pigmentosa). The epiretinal strategy, which was pioneered by our team, involves implanting the stimulating electrodes near the inner retinal surface. Compared with other strategies, epiretinal implantation surgeries are easier and ...

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    5. University of Iowa receives a NIH Grant for Three-Dimensional Structural-Function Relationships in Glaucoma from SD-OCT

      University of Iowa receives a NIH Grant for Three-Dimensional Structural-Function Relationships in Glaucoma from SD-OCT

      University of Iowa receives a 2015 NIH Grant for $229,750 for Three-Dimensional Structural-Function Relationships in Glaucoma from SD-OCT. The principal investigator is Milan Sonka. Below is a summary of the proposed work. This Phase-II proposal seeks to elucidate the structure-function relationships between visual field threshold sensitivity and the structural features of the retinal layers, the optic nerve head, and the connecting nerve fiber bundles in glaucoma. This proposal extends our successful Phase-I research that established structure- structure relationships among retinal quantitative indices. In this Phase II, further advancements of spectral domain optical coherence tomography (SD OCT) image analysis will ...

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    6. Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.

      Duke University Receives NIH Grant for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care.

      Duke University Receives a 2015 NIH Grant for $344,421 for Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care. The principal investigator is Anthony Kuo. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. This research proposal from a multi-disciplinary team of ophthalmologists and biomedical engineers seeks to improve the accuracy of OCT representations of the eye and hence the clinical and research measurements made from OCT images. Hardware and algorithmic innovations will be made and then applied to two important clinical diagnostic measurements. In the anterior eye ...

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    7. Detection and Intraretinal Localization of an ‘Invisible' Retinoblastoma Using Optical Coherence Tomography

      Detection and Intraretinal Localization of an ‘Invisible' Retinoblastoma Using Optical Coherence Tomography

      Purpose: To report the use of handheld spectral-domain optical coherence tomography (HHSD OCT) to identify and define the intraretinal location of a small retinoblastoma that was not detectable by indirect ophthalmoscopy. Methods: This is a retrospective case report of a tumor identified with HHSD OCT in a single patient. Results: A 7-week-old male was diagnosed with unilateral group E retinoblastoma in the right eye. An enucleation was completed successfully with histopathologic confirmation of the diagnosis. The normal left eye was monitored for the development of retinoblastoma, and 10 weeks after diagnosis, three new small retinoblastomas were noted in the posterior ...

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    8. Reconstruction of 3D surface maps from anterior segment optical coherence tomography images using graph theory and genetic algorithms

      Reconstruction of 3D surface maps from anterior segment optical coherence tomography images using graph theory and genetic algorithms

      Automatic segmentation of anterior segment optical coherence tomography images provides an important tool to aid management of ocular diseases. Previous studies have mainly focused on 2D segmentation of these images. A novel technique capable of producing 3D maps of the anterior segment is presented here. This method uses graph theory and dynamic programming with shape constraint to segment the anterior and posterior surfaces in individual 2D images. Genetic algorithms are then used to align 2D images to produce a full 3D representation of the anterior segment. In order to validate the results of the 2D segmentation comparison is made to ...

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    9. Argon Green Laser for Valsalva Retinopathy Treatment and Long-term Follow-up of the Internal Limiting Membrane Changes in Optical Coherence Tomography

      Argon Green Laser for Valsalva Retinopathy Treatment and Long-term Follow-up of the Internal Limiting Membrane Changes in Optical Coherence Tomography

      Dear Editor, We experienced a case of sub-internal limiting membrane (ILM) hemorrhage successfully treated with an argon green laser (AGL) posterior hyaloidotomy. We could not identify any report in the ophthalmic literature describing spectral domain optic coherence tomography (OCT) localization of AGL spots or preoperative exact anatomic localization in valsalva retinopathy. A 35-year-old man presented with sudden blurred vision in the right eye that occurred one day before examination. Dilated fundus examination of the right eye showed a well-circumscribed large sub-ILM hemorrhage in the temporal macular area ( Fig. 1A ). Fluid was noted in the upper part of the hemorrhage. OCT ...

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    10. Introducing Augmented Reality to Optical Coherence Tomography in Ophthalmic Microsurgery

      Introducing Augmented Reality to Optical Coherence Tomography in Ophthalmic Microsurgery

      Augmented Reality (AR) in microscopic surgery has been subject of several studies in the past two decades. Nevertheless, AR has not found its way into everyday microsurgical workflows. The introduction of new surgical microscopes equipped with Optical Coherence Tomography (OCT) enables the surgeons to perform multimodal (optical and OCT) imaging in the operating room. Taking full advantage of such elaborate source of information requires sophisticated intraoperative image fusion, information extraction, guidance and visualization methods. Medical AR is a unique approach to facilitate utilization of multimodal medical imaging devices. Here we propose a novel medical AR solution to the long-known problem ...

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    11. Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes

      Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes

      Purpose To assess and compare choroidal thickness changes related to aging, we determined whether changes are due to thinning of the choriocapillaris plus Sattler's (CS) layer and/or the large vessel layer in healthy eyes using swept-source optical coherence tomography (SS-OCT) at a wavelength of 1,050-nm. Methods We studied 115 normal eyes of 115 healthy volunteers, all with refractive errors of less than -6 diopters. All 115 eyes underwent analysis of choroidal thickness at the fovea, the CS layer and the large choroidal vessel layer. In 68 of the 115 eyes, choroidal thickness was determined at five sites ...

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    12. Advances in Ophthalmologic Imaging

      Advances in Ophthalmologic Imaging

      The role of imaging in glaucoma started with simple disc photography, which made it possible to record and compare qualitative changes in the optic nerve over time. Photography alone relies on subjective analysis, however, so clinicians can miss early changes in the optic nerve head (ONH). Advances have been made in producing stereoscopic images using flicker photography, which, when employed, improves interobserver agreement on neuroretinal rim width. 1 Digital evaluation in the form of optical coherence tomography (OCT) is now the most widely adopted modality for the diagnosis and management of glaucoma. Analysis of the retinal nerve fiber layer (RNFL ...

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    13. Quantification of the filtering bleb's structure with anterior segment optical coherence tomography

      Quantification of the filtering bleb's structure with anterior segment optical coherence tomography

      Background To determine the relationship between post-trabeculectomy bleb structure evaluated using anterior segment optical coherence tomography (AS-OCT) and postoperative intraocular pressure (IOP). Design Retrospective. Participants Twenty-seven eyes of 27 trabeculectomy patients. Methods We drew contour lines for the bleb and cleft on 8-radius-scanned AS-OCT images, and determined correlations of AS-OCT measurements to postoperative IOP at 6 months. Main Outcome Measures AS-OCT measurements of bleb structure, including cleft volume, wall volume, and the brightness of the bleb wall. Results We found significant correlations between postoperative IOP at 6 months and cleft volume at 3 and 6 months (r = -0.56, P ...

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    14. Ultra-Short-Term Reproducibility of Speckle-Noise Freed Fluid and Tissue Compartmentalization of the Choroid Analyzed by Standard OCT

      Ultra-Short-Term Reproducibility of Speckle-Noise Freed Fluid and Tissue Compartmentalization of the Choroid Analyzed by Standard OCT

      Purpose : We measured reproducibility of speckle-noise freed fluid and tissue compartmentalization of the choroid (choroidal angiography and tissue characterization). Methods : This study included 26 eyes of 13 healthy females: 13 were used for repeated measurements and 13 were used for side comparison. A semiautomated algorithm removed speckle-noise with structure preservation. Results : Intraclass correlation (ICC), with respect to reproducibility of the method, showed an ICC for choroidal fluid inner space analysis (FISA) of 95.15% (90.01–98.24). The ICC of tissue inner space analysis (TISA) was 99.75% (99.47–99.91). The total choroid ratio (TCR), calculated from ...

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    15. SERIAL "EN FACE" OPTICAL COHERENCE TOMOGRAPHY IMAGING OF SLOWLY RESORBING SUBRETINAL FLUID AFTER PNEUMATIC RETINOPEXY

      SERIAL "EN FACE" OPTICAL COHERENCE TOMOGRAPHY IMAGING OF SLOWLY RESORBING SUBRETINAL FLUID AFTER PNEUMATIC RETINOPEXY

      Purpose: To describe the use and utility of serial "en face" C-scan optical coherence tomography in following the postoperative subretinal fluid status in a patient after pneumatic retinopexy treatment of a rhegmatogenous retinal detachment. Method: Case study. Results: Serial "en face" optical coherence tomography imaging enhanced postoperative follow-up of persistent subretinal fluid, demonstrating its spontaneous disappearance over time. Conclusion: Previous studies showed that subretinal fluid persists in a large proportion of patients after rhegmatogenous retinal detachment repair (especially in those with a chronic component). "En face" optical coherence tomography imaging is a valuable tool for demonstrating postoperative fluid status and ...

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    16. OPTICAL COHERENCE TOMOGRAPHY FEATURES OF ACTIVE AND INACTIVE RETINAL NEOVASCULARIZATION IN PROLIFERATIVE DIABETIC RETINOPATHY

      OPTICAL COHERENCE TOMOGRAPHY FEATURES OF ACTIVE AND INACTIVE RETINAL NEOVASCULARIZATION IN PROLIFERATIVE DIABETIC RETINOPATHY

      Purpose: To describe spectral domain-optical coherence tomography features of retinal neovascularization in proliferative diabetic retinopathy and thus to identify novel signs of new vessel activity. Methods: Retrospective, cross-sectional study. Data were collected over a 9-month period. Spectral domain optical coherence tomography scans were performed over areas of new vessel complexes (NVC) in both the disk and elsewhere, and were qualitatively graded by two masked observers. New vessel complexes activity was determined using clinical and angiographic criteria and correlated with spectral domain optical coherence tomography features. Results: Forty-three eyes of 30 patients with proliferative diabetic retinopathy were included. Sixty-one NVC lesions ...

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    17. Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging

      Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging

      The recent development of optical coherence tomography in ophthalmology has shown great interests in using the system in 1 µm in contrast to 800 nm wavelength range due to the less reflection and absorption of retinal pigment epithelium and pigmented choroidal melanocytes in 1 µm wavelength. The clinical value of using 1 µm system has been demonstrated in choroid imaging, retinal and choroidal microcirculation, etc. By examining different aspects of the posterior eye, the specificity and sensitivity of diagnosis can be increased. On the other hand, higher speed can greatly reduce the measuring time and motion artifacts, which brings comfort ...

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    18. Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes

      Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes

      Purpose : The purpose of this study is to compare anterior segment-optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure and acute primary angle closure (APAC) eyes. Methods : In this cross-sectional case series, a total of 134 patients with phacomorphic angle closure (28 eyes) or APAC (54 eyes), as well as normal control subjects (52 eyes), were enrolled. Patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth (ACD), anterior chamber area (ACA), iris thickness (IT), iris curvature, lens vault (LV), anterior vault (AV), and angle parameters including angle opening distance (AOD 500 and AOD750) and trabecular iris ...

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      Mentions: Shan C. Lin UCLA UCSF
    19. Optical Coherence Tomography Angiography of a Choroidal Neovascularization in Adult Onset Foveomacular Vitelliform Dystrophy: Pearls and Pitfalls

      Optical Coherence Tomography Angiography of a Choroidal Neovascularization in Adult Onset Foveomacular Vitelliform Dystrophy: Pearls and Pitfalls

      Purpose : The purpose of this study was to determine the sensitivity and specificity of optical coherence tomography angiography (OCT-A) in detecting choroidal neovascularization (CNV)-complicating adult onset foveomacular vitelliform dystrophy (AOFVD) and to highlight the possible pitfalls related to the heterogeneous spectrum of acquired vitelliform maculopathies. Methods : Twenty-five eyes of 22 consecutive AOFVD patients with suspected CNV were enrolled. Conventional multimodal imaging findings, based on fluorescein angiography (FA), indocyanine green angiography (ICGA) and B-Scan OCT, were used as a basis and were compared with those obtained from OCT-A to define its sensitivity and specificity for detecting CNV in the case ...

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    20. Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography

      Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography

      Purpose To predict the development of glaucomatous visual field (VF) defects using Fourier-domain optical coherence tomography (FD-OCT) measurements at baseline visit. Design Multi-center longitudinal observational study. Glaucoma suspects and pre-perimetric glaucoma participants in the Advanced Imaging for Glaucoma Study. Methods The optic disc, the peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) were imaged with FD-OCT VF was assessed every 6 months. Conversion to perimetric glaucoma was defined by VF pattern standard deviation (PSD) or glaucoma hemifield test (GHT) outside normal limits on 3 consecutive tests. Hazard ratios were calculated with the Cox proportional hazard model ...

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    21. Optical coherence tomography angiography in patients with polypoidal choroidal vasculopathy

      Optical coherence tomography angiography in patients with polypoidal choroidal vasculopathy

      Purpose To report the characteristics of polypoidal choroidal vasculopathy (PCV) based on optical coherence tomography angiography (OCTA) results. Method A retrospective, cross-sectional case series was conducted. Patients treated for PCV were evaluated with the OCTA system. The OCTA images of these patients were compared with those from indocyanine green angiography (ICGA). All eyes of consecutive patients with PCV were included. Results The mean age of the patients (five men and two women) was 67.86 ± 14.02 years. The mean number of anti-vascular endothelial growth factor injections was 10.43 ± 10.01. OCTA demonstrated branched vascular networks, which were detected ...

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    22. Optic nerve head and fibre layer imaging for diagnosing glaucoma

      Optic nerve head and fibre layer imaging for diagnosing glaucoma

      The diagnosis of glaucoma is traditionally based on the finding of optic nerve head (ONH) damage assessed subjectively by ophthalmoscopy or photography or by corresponding damage to the visual field assessed by automated perimetry, or both. Diagnostic assessments are usually required when ophthalmologists or primary eye care professionals find elevated intraocular pressure (IOP) or a suspect appearance of the ONH. Imaging tests such as confocal scanning laser ophthalmoscopy (HRT), optical coherence tomography (OCT) and scanning laser polarimetry (SLP, as used by the GDx instrument), provide an objective measure of the structural changes of retinal nerve fibre layer (RNFL) thickness and ...

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    23. RETINAL ASTROCYTIC HAMARTOMA: Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex

      RETINAL ASTROCYTIC HAMARTOMA: Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex

      Purpose: To propose a classification of retinal astrocytic hamartoma based on spectral domain optical coherence tomography and correlate each class with systemic manifestations of tuberous sclerosis complex. Methods: Retrospective chart review conducted at four international referral medical retina centers. There were 43 consecutive patients with an established diagnosis of tuberous sclerosis complex based on presence of at least 2 major or 1 major and 2 minor features of the diagnostic criteria. Clinical and spectral domain optical coherence tomography features regarding retinal astrocytic hamartoma were documented. Results: The mean patient age at presentation was 16.2 years. The retinal astrocytic hamartoma ...

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