1. Articles in category: Ophthalmology

    553-576 of 6177 « 1 2 ... 21 22 23 24 25 26 27 ... 256 257 258 »
    1. Relationship Between Presence of Foveal Bulge in Optical Coherence Tomographic Images and Visual Acuity After Rhegmatogenous Retinal Detachment Repair

      Relationship Between Presence of Foveal Bulge in Optical Coherence Tomographic Images and Visual Acuity After Rhegmatogenous Retinal Detachment Repair

      Purpose: To determine whether a significant correlation exists between the presence of a bulge in the photoreceptor inner segment/outer segment line and the best-corrected visual acuity in eyes after successful rhegmatogenous retinal detachment (RRD) repair. Methods: Patients who had undergone successful RRD repair and had an intact inner segment/outer segment line at the central fovea in the spectral-domain optical coherence tomographic images were retrospectively studied. Thirty-five eyes of 35 patients were evaluated, and the eyes were classified preoperatively into those with macula-on RRD (n = 14) and those with macula-off RRD (n = 21). Examination of the spectral-domain optical coherence ...

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    2. Imaging of Naive Myopic Choroidal Neovascularization by Spectral-Domain Optical Coherence Tomography

      Imaging of Naive Myopic Choroidal Neovascularization by Spectral-Domain Optical Coherence Tomography

      Purpose: To assess the tomographic features of myopic choroidal neovascularization by spectral-domain optical coherence tomography. Methods: We consecutively reviewed the charts of patients with pathologic myopia, recent visual acuity deterioration and active macular neovascularization. Specific tomographic changes were studied in 25 eyes by two authors independently. Results: The mean age of patients eligible for the study was 63.4 (±18.2) years. Main tomographic outcomes were the hyperreflectivity of the lesion in 88% of cases (95% CI 0.74-1.02), absence of the external limiting membrane in 88% (95% CI 0.84-1.02), and retinal thickening in 83% (95% CI ...

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      Mentions: Luisa Pierro
    3. Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach

      Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach

      Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach. The principle investigator is Mona Garvin. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. This Career Development Award-2 (CDA-2) is for supporting an early-career engineering faculty member for three years. It will provide the means to train a young researcher currently possessing broad image analysis experience and narrowly focused expertise in one ophthalmic imaging modality (optical coherence tomography, OCT) in a multitude of ophthalmic modalities and clinical areas, with a special focus on glaucoma ...

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    4. Wavefront Error Correction with Adaptive Optics in Diabetic Retinopathy

      Wavefront Error Correction with Adaptive Optics in Diabetic Retinopathy

      Purpose: To determine the effects of diabetic retinopathy (DR), increased foveal thickness (FT), and adaptive optics (AO) on wavefront aberrations and Shack-Hartmann (SH) image quality. Methods: Shack-Hartmann aberrometry and wavefront error correction were performed with a bench-top AO retinal imaging system in 10 healthy control and 19 DR subjects. Spectral domain optical coherence tomography was performed and central FT was measured. Based on the FT data in the control group, subjects in the DR group were categorized into two subgroups: those with normal FT and those with increased FT. Shack-Hartmann image quality was assessed based on spot areas, and high-order ...

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    5. Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease

      Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease

      Spectral-domain Optical coherence tomography (OCT) has shown remarkable utility in the study of retinal disease and has helped to characterize the fovea in Parkinson disease (PD) patients. We developed a detailed mathematical model based on raw OCT data to allow differentiation of foveae of PD patients from healthy controls. Of the various models we tested, a difference of a Gaussian and a polynomial was found to have "the best fit". Decision was based on mathematical evaluation of the fit of the model to the data of 45 control eyes versus 50 PD eyes. We compared the model parameters in the ...

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    6. Spectral domain optical coherence tomography in children: normative data and biometric correlations

      Spectral domain optical coherence tomography in children: normative data and biometric correlations

      Background This study aims at reporting normative values of retinal nerve fiber layer (RNFL) and macular parameters in children using spectral domain optical coherence tomography (OCT) and to perform correlations with age, refractive error and axial length. Methods This was an observational cross-sectional study recruiting 113 healthy children aged 6 to 17 years with no ocular abnormality except refractive error. After a comprehensive eye examination and axial length measurement, RNFL and macular thickness measurements were performed using the Cirrus OCT machine. Main outcome measures were macular volume, macular thickness and RNFL thickness values as well as their correlations with age ...

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    7. Tear fluid signs associated with filtration blebs, as demonstrated by three-dimensional anterior segment optical coherence tomography

      Tear fluid signs associated with filtration blebs, as demonstrated by three-dimensional anterior segment optical coherence tomography

      Purpose: To determine the clinical features of tear fluid signs associated with filtration blebs via three-dimensional anterior segment optical coherence tomography (3D AS-OCT). Methods: In total, 152 eyes (130 patients) with glaucoma that underwent trabeculectomy with mitomycin C were evaluated retrospectively. We investigated tear fluid signs associated with filtration blebs, using 3D AS-OCT with custom software, and compared the findings of lower tear meniscus. We also analyzed postoperative intraocular pressure and the bleb parameters of filtration blebs between eyes with and without tear fluid signs. Results: We found tear fluid signs associated with filtration blebs in 45 (30%) of 152 ...

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    8. Proposed Lexicon for Anatomic Landmarks in Normal Posterior Segment Spectral-Domain Optical Coherence Tomography: The IN•OCT Consensus

      Proposed Lexicon for Anatomic Landmarks in Normal Posterior Segment Spectral-Domain Optical Coherence Tomography: The IN•OCT Consensus

      Purpose To develop a consensus nomenclature for the classification of retinal and choroidal layers and bands visible on spectral-domain optical coherence tomography (SD-OCT) images of a normal eye. Design An international panel with expertise in retinal imaging (International Nomenclature for Optical Coherence Tomography [IN•OCT] Panel) was assembled to define a consensus for OCT imaging terminology. Participants A panel of retina specialists. Methods A set of 3 B-scan images from a normal eye was circulated to the panel before the meeting for independent assignment of nomenclature to anatomic landmarks in the vitreous, retina, and choroid. The outputs were scrutinized, tabulated ...

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    9. Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture

      Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture

      Purpose To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT). Methods Thirty-nine eyes (8 healthy, 19 glaucoma suspects and 12 glaucoma) from 49 subjects were scanned twice using swept-source (SS−) OCT in a 3.5×3.5×3.64 mm (400×400×896 pixels) volume centered on the optic nerve head, with the focus readjusted after each scan. The LC was automatically segmented and analyzed for microarchitectural parameters, including pore diameter, pore diameter standard deviation (SD), pore aspect ratio, pore area, beam thickness, beam thickness SD, and ...

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    10. Swept-source OCT and glaucoma

      Swept-source OCT and glaucoma

      A technology being investigated for use in posterior segment imaging may have a role in glaucoma diagnosis, according to the literature First there was time-domain optical coherence tomography (TD-OCT), then spectral-domain OCT (SD-OCT); now a newer technology—swept-source OCT—may be able to image structures that the previous technologies could not, according to researchers involved in clinical studies of the device. "With swept-source technology, a frequency swept light source and a high speed detector are used to detect the interference signal as a function of time, instead of a spectrometer and camera as in spectral-domain technology," explained James G. Fujimoto ...

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    11. Orthogonal dispersive spectral-domain optical coherence tomography

      Orthogonal dispersive spectral-domain optical coherence tomography

      Ultrahigh depth range spectral domain optical coherence tomography (SDOCT) can be realized based on the orthogonal dispersive spectrometer consisted by a high spectral resolution virtually-imaged phased array (VIPA) and a low spectral resolution grating. However, two critical issues result in the challenge of obtaining desirable one-dimensional (1-D) spectra from the recorded two-dimensional (2-D) orthogonal spectra for high-quality OD-SDOCT imaging. One is the wavenumber mapping errors and the other is the periodic intensity modulations. The paper proposes a method for desirable reconstruction of 1-D spectra from the recorded 2-D orthogonal spectra. A sample etalon with identical parameters to the dispersive VIPA ...

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    12. Intra-operative OCT devices for ophthalmic use: an overview

      Intra-operative OCT devices for ophthalmic use: an overview

      It is feasible to bring the currently most used examination method in ophthalmology, optical coherence tomography (OCT), into ophthalmic surgery to enhance information and control for the surgeon and increase outcome for the patient. In this overview, the currently commercially available OCT devices intending intra-operative OCT imaging are described. Further experience with these systems might not only aid in solving current problems but also open our minds to detect processes so far unknown and help answer questions so far unaddressed.

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    13. Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Purpose: Subthreshold laser treatment of diabetic macular edema (DME) may have less deleterious effects on the photoreceptors than regular continuous wave laser. This study aimed to assess whether subthreshold laser causes a long-term damage to the retinal structures, as demonstrated by spectral-domain optical coherence tomography (SD-OCT), and to evaluate the change in the axial diameter of retinal diabetic microaneurysms following treatment. Methods: A retrospective study of eyes that were diagnosed with non-foveal involving DME and underwent subthreshold laser treatment with the Lumenis Novus SRT system. SD-OCT scans of treated retinal areas, performed prior to treatment and approximately 4 months following ...

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    14. Hyperreflective Pyramidal Structures on Optical Coherence Tomography in Geographic Atrophy Areas

      Hyperreflective Pyramidal Structures on Optical Coherence Tomography in Geographic Atrophy Areas

      Purpose: We observed hyperreflective dome-shaped or pyramidal structures (HPS) on spectral domain optical coherence tomography (SD-OCT) in patients affected with geographic atrophy (GA). Our purpose was to describe the multimodal imaging features of HPS identified in areas of GA in patients with age-related macular degeneration. Methods: This is a retrospective case series of patients with GA harboring HPS in atrophic areas. Multimodal imaging examination including infrared reflectance, fundus autofluorescence, and SD-OCT, was performed for each patient. Infrared and fundus autofluorescence appearance and mean SD-OCT height of HPS in GA were analyzed. Results: A total of 36 eyes of 25 patients ...

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    15. Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Purpose: To calculate and validate a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD). Method: AD patients (n=151) and age-matched, healthy subjects (n=61) were enrolled. The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. A LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided ...

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    16. Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

      Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

      Purpose To report the observation of hyper-reflective dots in the vitreous cavity using spectral domain optical coherence tomography (SD-OCT) after uneventful phacoemulsification cataract surgery and to investigate their association with cystoid macular edema (CME). Materials and Methods Medical records of consecutive Asian patients who had no preoperative retinopathy and underwent uneventful phacoemulsification cataract surgery from March 2012 through February 2013 were reviewed. SD-OCTs were performed before, 1 week, and 1 month after surgery. The number of vitreous hyper-reflective dots (VHDs) was counted in 5 OCT images of high-definition 5-line raster scans. The development of CME was assessed using postoperative 1-month ...

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    17. Measurement of wavefront aberrations and lens deformation in the accommodated eye with optical coherence tomography-equipped wavefront system

      Measurement of wavefront aberrations and lens deformation in the accommodated eye with optical coherence tomography-equipped wavefront system

      To quantitatively approach the relationship between optical changes in an accommodated eye and the geometrical deformation of its crystalline lens, a long scan-depth anterior segment OCT equipped wavefront sensor was developed and integrated with a Badal system. With this system, accommodation was stimulated up to 6.0D in the left eye and also measured in the same eye for three subjects. High correlations between the accommodative responses of refractive power and the radius of the anterior lens surface were found for the three subjects (r>0.98). The change in spherical aberration was also highly correlated with the change in ...

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    18. Advancing OCT Algorithmic Standardization

      Advancing OCT Algorithmic Standardization

      Neovascular exudative AMD (wet AMD) continues to rank as a top reason to visit eye care specialists, and the early identification of this disease has important prognostic implications for patients. 1 Advancements in optical coherence tomography (OCT) imaging have surpassed other modalities in the ability to detect the earliest development of wet AMD and prompt treatment initiation, in spite of lack of inter- and intradevice standardization. 2 , 3 Zhang et al. 4 present a novel, automated way to detect changes at the border where choroidal neovascularization (CNV) first affects the retina. They use a technique that presents an automated method ...

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    19. Virtual reality simulator for vitreoretinal surgery using integrated OCT data

      Virtual reality simulator for vitreoretinal surgery using integrated OCT data

      Operative practice using surgical simulators has become a part of training in many surgical specialties, including ophthalmology. We introduce a virtual reality retina surgery simulator capable of integrating optical coherence tomography (OCT) scans from real patients for practicing vitreoretinal surgery using different pathologic scenarios.

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      Mentions: Igor Kozak
    20. Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome

      Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome

      PurposeTo describe the characteristic optical coherence tomography (OCT) findings of the iris in Cogan-Reese syndrome.MethodsA 63-year-old woman was referred for consultation due to diffuse pigmentation of the iris and elevated intraocular pressure (IOP) in the left eye. The clinical examination revealed Cogan-Reese syndrome with pedunculated iris outcroppings on the entire iris surface, and no peripheral anterior synechia. The right eye was normal with normal IOP.ResultsImaging the left iris with the CAM-L cornea lens adapter of the Optovue Fourier-domain OCT (RTVue-OCT) showed a folded iris surface, an increased total iris thickness, and an increased distance between the anterior and ...

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    21. Choroidal thinning in pseudoexfoliation syndrome detected by enhanced depth imaging optical coherence tomography

      Choroidal thinning in pseudoexfoliation syndrome detected by enhanced depth imaging optical coherence tomography

      PurposeTo measure choroidal thickness in patients with pseudoexfoliation (PEX) syndrome and to compare the values with control eyes using enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsThirty-four patients with PEX syndrome and 30 age- and sex-matched healthy subjects were included in this study. Only one eye of each of the patients was included. Choroidal thickness was measured manually from the outer border of the retinal pigment epithelium to the inner scleral border at the subfovea, 3 mm temporal to the fovea, and 3 mm nasal to the fovea using EDI-OCT.ResultsA total of 34 eyes from 34 consecutive patients with ...

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    22. Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography

      Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography

      Purpose to distinguish differences in retinal nerve fiber layer (RNFL) thickness and peripapillary total retinal volume between eyes with papilledema, pseudopapilledema, and normal findings. Design Cohort study Methods Forty-two eyes with mild papilledema, 37 eyes with congenitally elevated optic disc (pseudopapilledema), and 34 normal eyes met the inclusion criteria at 1 academic institution (in Iran) and underwent neuro-ophthalmic examination. Spectral-domain optical coherence tomography scans surrounding the optic disc were performed in each eye of patients and subjects. Main outcome measures were mean RNFL thickness and peripapillary total retinal volume measurements (inner and outer rings volumes) that were compared between groups ...

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    23. In vivo analysis of the iris thickness by spectral domain optical coherence tomography

      In vivo analysis of the iris thickness by spectral domain optical coherence tomography

      Purpose To assess the effectiveness of spectral domain optical coherence tomography (SD-OCT) in providing in vivo measurements of iris thickness in healthy and pathological subjects. Methods 14 healthy volunteers and 14 patients with unilateral Fuchs’ uveitis were enrolled in the study. The two groups were comparable for age, gender and race. Each subject underwent complete clinical examination and anterior segment SD-OCT imaging in both eyes. SD-OCT scans of the iris were performed following a cross-sectional pattern. Iris thickness values were obtained using a purposely developed software-based analysis of OCT images. Measurements were carried out twice by two trained independent operators ...

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    24. Imaging apparatus and ophthalmic apparatus

      Imaging apparatus and ophthalmic apparatus

      An imaging apparatus for obtaining a tomographic image of an object based on light obtained by combining returning light from the object, which is irradiated with measurement light, and reference light corresponding to that measurement light, the imaging apparatus comprising: a reference light splitting unit adapted to split the reference light into a plurality of reference light beams of different wavelength ranges, and a plurality of dispersion compensation units adapted to compensate dispersion in accordance with wavelength ranges of the plurality of reference light beams, the dispersion compensation units being provided in respective light paths of the plurality of reference ...

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