1. Articles in category: Ophthalmology

    553-576 of 10490 « 1 2 ... 21 22 23 24 25 26 27 ... 435 436 437 »
    1. Comparison of Anterior Segment Parameters Obtained by Anterior Segment Optical Coherence Tomography and Dual Rotating Scheimpflug Camera

      Comparison of Anterior Segment Parameters Obtained by Anterior Segment Optical Coherence Tomography and Dual Rotating Scheimpflug Camera

      Purpose To compare the anterior segment measurements with a Galilei® dual Scheimpflug analyzer and anterior segment optical coherence tomography (Cirrus OCT®). Methods Forty-eight eyes of 24 normal young adults were assessed for repeatability with two identical measurements of the central corneal thickness, minimum corneal thickness, anterior chamber depth, and anterior chamber angle using the Galilei® dual-Scheimpflug analyzer and Cirrus OCT®. Results The central corneal thickness, anterior chamber depth, and anterior chamber angle were highly reproducible and repeatable (intraclass correlation coefficient ≥ 0.90). Repeatability of the minimum corneal thickness was slightly lower (intraclass correlation coefficient ≥ 0.69). The mean corneal thickness ...

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    2. Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy

      Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy

      Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory disorders of the central nervous system (CNS). Optic neuritis (ON) is the first NMOSD-related clinical event in 55% of the patients, which causes damage to the optic nerve and leads to visual impairment. Retinal optical coherence tomography (OCT) has emerged as a promising method for diagnosis of NMOSD and potential individual monitoring of disease course and severity. OCT not only detects damage to the afferent visual system caused by ON but potentially also NMOSD-specific intraretinal pathology, i.e. astrocytopathy. This article summarizes retinal involvement in NMOSD and reviews OCT methods that ...

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      Mentions: Friedemann Paul
    3. Optical Coherence Tomography Angiography in Healthy Subjects and Diabetic Patients

      Optical Coherence Tomography Angiography in Healthy Subjects and Diabetic Patients

      Fluorescein angiography and indocyanine green angiography provide information about the normal retinal and choroidal vascular perfusion. They allow the evaluation of different diseases and increase the capability to define and diagnose several pathological conditions. Fluorescein angio graphy is the “gold standard” in imaging the retinal vascular bed and its changes, although not all the different layers of the capillary network can be visualized in a bidimensional examination. Optical coherence tomography angiography allows a depth-resolved visualization of the retinal and choroidal microvasculature, by calculating the difference (decorrelation) between static and nonstatic tissue. Given that the main moving elements in the eye ...

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    4. Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Background/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the macula with scanning lines analysed by two ophthalmologists to assess for the presence of 12 different posterior segment lesions. Per cent agreement for each lesion between the graders and quantitative ...

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    5. Optical coherence tomography angiography in retinal cavernous hemangioma

      Optical coherence tomography angiography in retinal cavernous hemangioma

      Cavernous hemangiomas of the retina are rare benign vascular tumors, commonly diagnosed in children and young adults. They are characterized by dilated blood vessels that form cavities or caverns through which the blood flow is very low or virtually absent [1] . Retinal lesions may be associated with cerebral hemangiomas [1] , which conversely, do not harbor any tissue within the malformation, the smooth muscle is impaired and there is no capsule surrounding the caverns. Cavernous hemangioma has also been associated with choroidal hemangioma [2] and ocular melanocytosis [3] . Retinal lesions vary in size and location, and generally follow the course of ...

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    6. Characteristics of the Choriocapillaris Layer in Optical Coherence Tomography Angiography of Acute Central Serous Chorioretinopathy

      Characteristics of the Choriocapillaris Layer in Optical Coherence Tomography Angiography of Acute Central Serous Chorioretinopathy

      BACKGROUND AND OBJECTIVE: To describe the vascular characteristics of the choriocapillaris layer in acute central serous chorioretinopathy (CSC) imaged by optical coherence tomography angiography (OCTA), and to analyze the vascular density. PATIENTS AND METHODS: Retrospective, observational case series. In the study, 20 eyes of patients with acute CSC and 20 normal individuals were selected. All underwent OCTA, and 3 mm × 3 mm scanning mode was chosen for analyzing vascular density and morphological characteristics on the choriocapillaris layer. RESULTS: A dark region with some hyperreflective signal spots on the choriocapillaris layer was found in all affected eyes' OCTA images. The choroidal ...

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    7. Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes

      Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes

      Aim To evaluate the correlation between inner retinal layer thinning and the foveal microvasculature in type 2 diabetes using optical coherence tomography angiography (OCTA). Methods A cross-sectional study involved 155 diabetic eyes. All patients were divided into two groups based on diabetic retinopathy (DR) grade: no DR (NDR, n=80) and mild-to-moderate non-proliferative DR (NPDR, n=75). Foveal avascular zone (FAZ) area, FAZ circularity index, FAZ perimeter, vessel density and perfusion index of parafoveal and perifoveal area were calculated using OCTA. The thickness of the macular ganglion cell/inner plexiform layer (mGCIPL) was measured using OCT. Results In both superficial ...

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    8. Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS

      Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS

      BACKGROUND AND OBJECTIVE: The aim of this study was to assess changes in retinal structure and thickness after subretinal implantation of the Retina Implant Alpha IMS (Retina Implant AG, Reutlingen, Germany). PATIENTS AND METHODS: Spectral-domain optical coherence tomography (SD-OCT) imaging was performed to assess the structure and thickness of the retina anterior to the microphotodiode array preoperatively, within 6 weeks and 6 months ± 1 month after implantation. Thickness measurements were performed using the distance tool of the built-in software. Three thickness measurements were performed in each of the four quadrants of the retina on the microchip within 6 weeks and ...

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    9. Optical Coherence Tomography in Optic Nerve Hypoplasia: Correlation With Optic Disc Diameter, Nerve Fiber Layer Thickness, and Visual Function

      Optical Coherence Tomography in Optic Nerve Hypoplasia: Correlation With Optic Disc Diameter, Nerve Fiber Layer Thickness, and Visual Function

      Background: The correlation between optic disc diameters (DDs) with average retinal nerve fiber layer thickness (RNFLT) and visual function in children with optic nerve hypoplasia (ONH) having nystagmus is unknown. Methods: Data were obtained from a retrospective review of 28 children (mean age: 9.4 years; ±5.1). Optic DD was defined as the maximal horizontal opening of Bruch membrane with spectral optical coherence tomography combined with a confocal laser ophthalmoscope. Average RNFLT was obtained from circumpapillary b-scans. RNFLT was also remeasured at eccentricities that were proportionate with DD to rule out potential sampling artifacts. Visual function was assessed by ...

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    10. Repeatability and reproducibility of automatic segmentation of retinal layers in healthy subjects using Spectralis optical coherence tomography

      Repeatability and reproducibility of automatic segmentation of retinal layers in healthy subjects using Spectralis optical coherence tomography

      Purpose: To evaluate the repeatability and reproducibility of automatic segmentation in healthy subjects using a Spectralis optical coherence tomography (OCT) system. Methods: A total of 60 eyes from 60 patients were included in this prospective study. Spectral-domain optical coherence tomography images were generated using the Spectralis OCT system. An automated algorithm was used to segment the macular retina into nine layers and evaluate the thickness of each layer in the foveal, inner, and outer Early Treatment Diabetic Retinopathy Study (ETDRS) subfield rings. The eyes were imaged three times by an examiner to assess intraobserver repeatability and imaged once by a ...

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    11. Automatic Subretinal Fluid Segmentation of Retinal SD-OCT Images With Neurosensory Retinal Detachment Guided by Enface Fundus Imaging

      Automatic Subretinal Fluid Segmentation of Retinal SD-OCT Images With Neurosensory Retinal Detachment Guided by Enface Fundus Imaging

      Objective: Accurate segmentation of neurosensory retinal detachment (NRD) associated subretinal fluid in spectral domain optical coherence tomography (SD-OCT) is vital for the assessment of central serous chorioretinopathy (CSC). A novel two-stage segmentation algorithm was proposed, guided by Enface fundus imaging. Methods: In the first stage, Enface fundus image was segmented using thickness map prior to detecting the fluid-associated abnormalities with diffuse boundaries. In the second stage, the locations of the abnormalities were used to restrict the spatial extent of the fluid region, and a fuzzy level set method with a spatial smoothness constraint was applied to subretinal fluid segmentation in ...

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    12. Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Purpose To determine whether the diameter of Bruch’s membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT). Methods The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were reviewed retrospectively. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Transverse horizontal diameter of the BMO and papillary height were measured. Mean BMO, papillary height, and RNFL were compared and receiver operating characteristic (ROC) curves were used to calculate the area under the curve (AUC) and determine ...

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    13. 1st OCT and OCT Angiography Course in Bucharest, Romania

      1st OCT and OCT Angiography Course in Bucharest, Romania

      We are pleased to announce the first OCT and OCT angiography course in Bucharest, Romania. The event is held on the 20th of January 2018. Hotel Novotel. Bucharest. Calea Victoriei 37B Registration is made by sending a mail at : office@clubulregal.ro . Also details could be provided at this mail address. Please do excuse that the site of the even is in Romanian. First part is dedicated to OCT role in ophthalmology including lectures on OCT in cornea pathology,retina pathology (degenerative, vascular, diabetic, vitreoretinian interfase), pediatric ophthalmology, oftalmiconcology, neuro-ophthalmology and glaucoma. Second part is dedicated to OCT angiography including ...

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    14. B.C. engineer develops scanner to diagnose eye diseases early and save vision

      B.C. engineer develops scanner to diagnose eye diseases early and save vision

      A British Columbia engineering science professor has developed a high-resolution scanner that he says will revolutionize how eye diseases are diagnosed to prevent vision loss. Prof. Marinko Sarunic of Simon Fraser University said doctors currently use low-resolution scanners that can assess the cause of patients' dead retina cells. "Because the resolution is low, they don't detect small changes, they detect big changes," he said. "What we want is to see the changes to the retinal structure before they're obvious in a person's vision." A scanner built on billiard-sized tables is now used at a few universities in ...

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    15. Optical coherence tomography angiography of diffuse unilateral subacute neuroretinitis

      Optical coherence tomography angiography of diffuse unilateral subacute neuroretinitis

      Purpose Diffuse unilateral subacute neuroretinitis (DUSN) is often a challenging diagnosis to make. We present a DUSN case with its multimodal imaging to aid in the diagnosis, emphasizing the observations on optical coherence tomography angiography (OCTA). Observations The evolution of a DUSN case is presented. Fundus photography and OCTA aided in the identification of the nematode. Conclusions and importance DUSN is a difficult diagnosis to establish. We report the first case to our knowledge in which OCTA aided in the diagnosis of DUSN.

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    16. Multimodal retinal imaging in central serous chorioretinopathy treated with oral eplerenone or photodynamic therapy

      Multimodal retinal imaging in central serous chorioretinopathy treated with oral eplerenone or photodynamic therapy

      Purpose To correlate function and structural optical coherence tomography (OCT) to optical coherence tomography angiography (OCT-A) measures in patients affected by central serous chorioretinopathy (CSC) and to describe their changes after treatments (ie oral eplerenone, half-fluence photodynamic therapy (PDT)). Patients and methods Twenty eyes of 16 consecutive patients with treatment-naïve CSC undergoing either eplerenone or PDT were enrolled in this prospective, observational study. All patients underwent structural OCT and OCT-A at baseline and after therapy at months 1 and 3. Results Eleven eyes of nine patients and nine eyes of seven patients underwent eplerenone or PDT treatment, respectively. Central ...

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    17. Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 2. Impacts of optic nerve head parameters

      Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 2. Impacts of optic nerve head parameters

      Clinicians use retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) as an adjunct to glaucoma diagnosis. Ametropia is accompanied by changes to the optic nerve head (ONH), which may affect how OCT machines mark RNFLT measurements as abnormal. These changes in abnormality patterns may bias glaucoma diagnosis. Here, we investigate the relationship between OCT abnormality patterns and the following ONH-related and ametropia-associated parameters on 421 eyes of glaucoma patients: optic disc tilt and torsion, central retinal vessel trunk location (CRVTL), and nasal and temporal retinal curvature adjacent to ONH, quantified as nasal/temporal slopes of the ...

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    18. Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 1. Impacts of refractive error and interartery angle

      Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 1. Impacts of refractive error and interartery angle

      Retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) is widely used in clinical practice to support glaucoma diagnosis. Clinicians frequently interpret peripapillary RNFLT areas marked as abnormal by OCT machines. However, presently, clinical OCT machines do not take individual retinal anatomy variation into account, and according diagnostic biases have been shown particularly for patients with ametropia. The angle between the two major temporal retinal arteries (interartery angle, IAA) is considered a fundamental retinal ametropia marker. Here, we analyze peripapillary spectral domain OCT RNFLT scans of 691 glaucoma patients and apply multivariate logistic regression to quantitatively compare ...

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    19. Multiscale sensorless adaptive optics OCT angiography system for in vivo human retinal imaging

      Multiscale sensorless adaptive optics OCT angiography system for in vivo human retinal imaging

      We present a multiscale sensorless adaptive optics (SAO) OCT system capable of imaging retinal structure and vasculature with various fields-of-view (FOV) and resolutions. Using a single deformable mirror and exploiting the polarization properties of light, the SAO-OCT-A was implemented in a compact and easy to operate system. With the ability to adjust the beam diameter at the pupil, retinal imaging was demonstrated at two different numerical apertures with the same system. The general morphological structure and retinal vasculature could be observed with a few tens of micrometer-scale lateral resolution with conventional OCT and OCT-A scanning protocols with a 1.7-mm-diameter ...

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    20. Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters

      Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters

      Purpose This study aimed to develop a machine learning-based algorithm for objective classification of the optic disc in patients with open-angle glaucoma (OAG), using quantitative parameters obtained from ophthalmic examination instruments. Methods This study enrolled 163 eyes of 105 OAG patients (age: 62.3 ± 12.6, mean deviation of Humphrey field analyzer: -8.9 ± 7.5 dB). The eyes were classified into Nicolela’s 4 optic disc types by 3 glaucoma specialists. Randomly, 114 eyes were selected for training data and 49 for test data. A neural network (NN) was trained with the training data and evaluated with the test ...

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    21. Outer Retinal Changes on Spectral-Domain Optical Coherence Tomography Pre- and Post-Silicone Oil Removal

      Outer Retinal Changes on Spectral-Domain Optical Coherence Tomography Pre- and Post-Silicone Oil Removal

      BACKGROUND AND OBJECTIVE: To evaluate outer retinal changes present on spectral-domain optical coherence tomography (SD-OCT) in eyes pre- and post-silicone oil (SiO) removal (SOR). PATIENTS AND METHODS: Retrospective case series of patients who underwent pars plana vitrectomy with SiO instillation and had SD-OCT completed pre- and post-SOR. SD-OCT parameters included presence of subretinal fluid, epiretinal membrane, ellipsoid zone disruption (EZD), external limiting membrane disruption, central subfield thickness (CST), and choroidal thickness. Visual acuities (VAs) and duration of SiO instillation were recorded. RESULTS: Thirty eyes of 30 patients were included. Mean Snellen VA pre- and post-SOR was 20/762 and 20 ...

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    22. Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2 with Associated Subretinal Neovascular Membrane

      Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2 with Associated Subretinal Neovascular Membrane

      Optical coherence tomography angiography (OCTA) is a recently established noninvasive technology for evaluation of the retinal and choroidal vasculature. The literature regarding the findings in macular telangiectasia type 2 (MacTel2) is scarce. We report the OCTA findings associated with a subject with MacTel2 and secondary subretinal neovascularization (SNV). The commercially available Cirrus 5000 with AngioPlex (Zeiss, Jena, Germany) was used, without any subsequent image modification or processing. Subretinal neovascularization was detectable with OCTA at the level of the outer retina and choriocapillaris. Microvascular abnormalities associated with MacTel2 were present mostly in the deep capillary plexus of the retina temporally.

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    23. Automatic optical coherence tomography imaging analysis for retinal disease screening (Thesis)

      Automatic optical coherence tomography imaging analysis for retinal disease screening (Thesis)

      The retina and the choroid are two important structures of the eye and on which the quality of eye sight depends. They have many tissue layers which are very important for monitoring the health and the progression of the eye disease from an early stage. These layers can be visualised using Optical Coherence Tomography (OCT) imaging. The abnormalities in these layers are indications of several eye diseases that can lead to blindness, such as Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD) and Glaucoma. If the retina and the choroid are damaged there is little chance to recover normal sight ...

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    24. Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease

      Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease

      Carotid artery disease (CAD) is characterized by stenosis or occlusion in the carotid arterial system. The most common cause of obstruction is atherosclerosis of the carotid artery, although inflammatory conditions such as giant cell arteritis, fibromuscular dysplasia, and Behçet’s disease can occasionally be responsible.1 According to the degree of involvement, especially when the internal carotid artery (ICA) is affected, this may lead to ipsilateral reduced retinal blood flow and eventually progress to ocular ischemic syndrome (OIS). OIS is a rare condition, but its complications may cause severe visual impairment. Most CAD patients have no ocular symptoms when ...

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