1. Articles in category: Ophthalmology

    553-576 of 6196 « 1 2 ... 21 22 23 24 25 26 27 ... 257 258 259 »
    1. Qualitative and quantitative analysis of filtering blebs with optical coherence tomography

      Qualitative and quantitative analysis of filtering blebs with optical coherence tomography

      Objective To provide a qualitative and quantitative analysis of filtering blebs with optical coherence tomography (OCT) in patients after primary trabeculectomy. Design Evaluation of diagnostic technology. Participants We retrospectively studied 20 eyes of 20 patients who had a fornix-based flap in primary trabeculectomy: 14 with mitomycin C (MMC) and 6 without MMC. Methods Filtering blebs were examined using 2 types of OCTs working at a wavelength of 840 and 1310 nm. In this study, we analyzed both the OCT morphologic pattern and the internal structures of blebs, including bleb wall thickness, scleral flap thickness, and the route under the scleral ...

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    2. Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography

      Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography

      Purpose To noninvasively evaluate the effects of corneal hydration and collagen crosslinking (CXL) on the mechanical behavior of the cornea. Setting Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA. Design Experimental study. Methods An optical coherence elastography (OCE) technique was used to measure the displacement behavior of 5 pairs of debrided human donor globes in 3 serial states as follows: edematous, normal thickness, and after riboflavin–ultraviolet-A–mediated CXL. During micromotor-controlled axial displacements with a curved goniolens at physiologic intraocular pressure (IOP), serial optical coherence tomography scans were obtained to allow high-resolution intrastromal speckle tracking and displacement measurements over the ...

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    3. Hyperreflective Foveal Lesion Observed With Optical Coherence Tomography in Cases of Epiretinal Membranes With A Firm Foveal Attachment

      Hyperreflective Foveal Lesion Observed With Optical Coherence Tomography in Cases of Epiretinal Membranes With A Firm Foveal Attachment

      Purpose: To report the optical coherence tomography (OCT) findings of the firmly attached foveal area and to investigate the functional results and predictive values in correlation to the degree of firmness of the foveal adherence of the epiretinal membrane (ERM). Methods: We retrospectively reviewed the medical records regarding 167 eyes of 166 patients who underwent vitrectomy for the removal of the ERM between January 2009 and December 2012. We evaluated the degree of foveal attachment in all the patients based on the surgical video and reviewed the OCT images. The main and secondary outcome measures were OCT findings including the ...

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    4. Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study

      Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study

      Significant integrative advances are needed for intraoperative optical coherence tomography ( i OCT) to achieve widespread use across ophthalmic surgery. A surgeon feedback system that provides microscope integration, heads-up display and foot pedal control of the OCT scan location represents a major interval advance in ophthalmic surgery. In this report, we describe the preliminary findings of the Determination of feasibility of Intraoperative Spectral domain microscope Combined/integrated OCT Visualisation during En face Retinal and ophthalmic surgery (DISCOVER) study, a multisurgeon investigational device study examining the role of microscope integrated i OCT systems with surgeon heads-up display feedback (eg, Carl Zeiss Meditec ...

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    5. Retinal nerve fibre layer and macular thickness analysis with Fourier domain optical coherence tomography in subjects with a positive family history for primary open angle glaucoma

      Retinal nerve fibre layer and macular thickness analysis with Fourier domain optical coherence tomography in subjects with a positive family history for primary open angle glaucoma

      Aim To detect early structural changes of retinal nerve fibre layer (RNFL) and macular ganglion cell complex (GCC) in subjects with a positive family history for primary open angle glaucoma (POAG) using Fourier domain optical coherence tomography (FD-OCT) (RTVue-100). Methods This was a cross-sectional observational study. First and second degree relatives of POAG patients, healthy subjects, and subjects with preperimetric glaucoma (PPG) without a family history for glaucoma, were enrolled. All participants underwent complete ophthalmic examination, visual field test and FD-OCT (RTVue-100) imaging. Average RNFL and GCC thicknesses were measured and a pattern analysis was applied to the GCC map ...

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    6. Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has revolutionises the diagnosis of retinal disease based on the detection of microscopic rather than subcellular changes in retinal anatomy. However, currently the technique is limited to the detection of microscopic rather than subcellular changes in retinal anatomy. However, coherence based imaging is extremely sensitive to both changes in optical contrast and cellular events at the micrometer scale, and can generate subtle changes in the spectral content of the OCT image. Here we test the hypothesis that OCT image speckle (image texture) contains information regarding otherwise unresolvable features such as organelle changes arising in the early ...

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    7. “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

      “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

      Purpose . The recent use of “en-face” enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS). Methods . Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan (“en-face”) EDI SD-OCT at the initial visit and during follow-up. Results . C-scans combined with the other multimodal imaging enabled the visualization of retinal damage. Acute lesions appeared as diffuse and focal disruptions occurring in the ellipsoid and interdigitation zones. The match between autofluorescence imaging, indocyanine green angiography, and “en-face” OCT helped identify the acute microstructural damages in ...

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    8. Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      PURPOSE: To measure macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and to correlate these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve. METHODS: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), the combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were qualitatively assessed for microcysts in the ...

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    9. A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      Purpose: The purpose of this work was to gather preliminary data on tear film stability and the adhesive properties of the corneal surface in dry eye patients and control-group subjects, using a new, minimally invasive OCT imaging method. Methods: Eighty-five human subjects were screened for dry eye and classified in two groups, as dry eye or normal patients. Sodium carboxymethylcellulose (NaCMC) adhesiveness over the central cornea was measured using Fourier Domain anterior segment optical coherence tomography (OCT). The corneal adhesiveness for NaCMC was compared between the two groups, correlated with classical tests, and analyzed for diagnostic validity and repeatability. Results ...

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    10. Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography

      Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography

      Real-time display of processed en-face spectral domain optical coherence tomography (SD-OCT) images is important for diagnosis. However, due to many steps of data processing requirements, such as Fast Fourier transformation (FFT), data re-sampling, spectral shaping, apodization, zero padding, followed by software cut of the 3D volume acquired to produce an en-face slice, conventional high-speed SD-OCT cannot render an en-face OCT image in real time. Recently we demonstrated a Master/Slave (MS)-OCT method that is highly parallelizable, as it provides reflectivity values of points at depth within an A-scan in parallel. This allows direct production of en-face images. In addition ...

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    11. Adaptive optics optical coherence tomography for in vivo retinal imaging (Thesis)

      Adaptive optics optical coherence tomography for in vivo retinal imaging (Thesis)

      Optical coherence tomography (OCT) is a non-invasive micrometer-resolution volumetric imaging modality that has been employed in diverse applications. In this thesis, we first describe a GPU accelerated program to perform FDOCT data processing and real time 3D volumetric rendering. The real time visualization of volumetric images provided by the GPU acceleration was essential to the rest of the work described in this thesis. Small animal models of retinal diseases serve as a vital component in vision research, and non-invasive in vivo imaging is becoming an increasingly important tool in the field. We describe the first adaptive optics optical coherence tomography ...

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    12. Subfoveal Choroidal Thickness in Patients with Chronic Heart Failure Analyzed by Spectral-Domain Optical Coherence Tomography

      Subfoveal Choroidal Thickness in Patients with Chronic Heart Failure Analyzed by Spectral-Domain Optical Coherence Tomography

      Purpose : To evaluate the subfoveal choroidal thickness (SFCT) measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in eyes of chronic heart failure (CHF) patients. Methods : Fifty-six patients with CHF and 56 age- and gender-matched healthy individuals were enrolled. The SFCT was measured by EDI-OCT. The ejection fraction of left ventricle (EFLV), age, intraocular pressure (IOP), axial length (AL), systolic and diastolic blood pressure, and ocular perfusion pressure (OPP) were also measured. Results : Mean SFCT was 181.2 ± 80.23 μm in the study group and 283.6 ± 52.4 μm in the control group ( p  = 0.000). There was ...

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    13. Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

      Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

      We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μ m, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument’s utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens ...

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    14. Agreement of Retinal Nerve Fiber Layer Defect Location Between Red-Free Fundus Photography and Cirrus HD-OCT Maps

      Agreement of Retinal Nerve Fiber Layer Defect Location Between Red-Free Fundus Photography and Cirrus HD-OCT Maps

      Purpose : To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps. Methods : We examined 380 RNFL defects that showed clear margins in red-free fundus photographs. The OCT deviation and thickness maps were overlaid on the corresponding red-free fundus photographs. A reference line was drawn between the disc center and the macular center. Lines were also drawn between the optic disc center and the point where the RNFL defect margins crossed the OCT scan circle. The ...

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    15. Interexaminer Reproducibility of Optical Coherence Tomography for Measuring the Tear Film Meniscus

      Interexaminer Reproducibility of Optical Coherence Tomography for Measuring the Tear Film Meniscus

      Purpose : New optical coherence tomography (OCT) devices with anterior segment module are able to measure the tear meniscus height (TMH) and tear meniscus area (TMA). Since the borders of the area and the height are to be marked by an examiner, the measurements are prone to be subjective. Herein, we aimed to evaluate the interexaminer reproducibility of the tear meniscus measurements with OCT. Materials and Methods : In this prospective cross-sectional study, both eyes of 300 consecutive patients with and without dry eye were studied. Following routine ophthalmologic examination, tear-film OCT images were obtained. Two examiners, who were unaware of the ...

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    16. Monitor Corneal Epithelial Healing Under Bandage Contact Lens Using Ultrahigh-Resolution Optical Coherence Tomography After Pterygium Surgery

      Monitor Corneal Epithelial Healing Under Bandage Contact Lens Using Ultrahigh-Resolution Optical Coherence Tomography After Pterygium Surgery

      Objective: To monitor corneal epithelial healing under bandage contact lens (BCL) using ultrahigh-resolution optical coherence tomography (UHR-OCT) after pterygium surgery. Methods: Thirty-nine eyes of 39 patients undergoing pterygium excision and conjunctival autografting were randomly allocated into 2 groups: 20 eyes were covered with silicone hydrogel BCLs at the end of surgery and 19 eyes served as a control. Ultrahigh-resolution optical coherence tomography scans of the cornea were performed sequentially at 1, 2, and 3 days, and then every other day until the end of re-epithelialization after surgery. Complete epithelial healing was verified with fluorescein staining examination after removal of BCLs ...

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    17. Visualisation of contrast-enhanced intraoperative optical coherence tomography with indocyanine green

      Visualisation of contrast-enhanced intraoperative optical coherence tomography with indocyanine green

      Optical coherence tomography (OCT)-based visualisation of ophthalmic anatomy has transformed the clinical practice of ophthalmology. The translation of OCT into the surgical theatre is currently being actively researched and may provide a paradigm shift in surgical practice. Enhanced visualisation of tissues and tissue planes may provide further iterative improvement in surgeon feedback. Contrast-enhanced intraoperative OCT ( i OCT) has been previously described with triamcinolone. In this report, we describe the OCT features and contrast enhancement noted with indocyanine green using i OCT in human subjects as well as an ex vivo analysis in porcine eyes.

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    18. Relationship Between Presence of Foveal Bulge in Optical Coherence Tomographic Images and Visual Acuity After Rhegmatogenous Retinal Detachment Repair

      Relationship Between Presence of Foveal Bulge in Optical Coherence Tomographic Images and Visual Acuity After Rhegmatogenous Retinal Detachment Repair

      Purpose: To determine whether a significant correlation exists between the presence of a bulge in the photoreceptor inner segment/outer segment line and the best-corrected visual acuity in eyes after successful rhegmatogenous retinal detachment (RRD) repair. Methods: Patients who had undergone successful RRD repair and had an intact inner segment/outer segment line at the central fovea in the spectral-domain optical coherence tomographic images were retrospectively studied. Thirty-five eyes of 35 patients were evaluated, and the eyes were classified preoperatively into those with macula-on RRD (n = 14) and those with macula-off RRD (n = 21). Examination of the spectral-domain optical coherence ...

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    19. Imaging of Naive Myopic Choroidal Neovascularization by Spectral-Domain Optical Coherence Tomography

      Imaging of Naive Myopic Choroidal Neovascularization by Spectral-Domain Optical Coherence Tomography

      Purpose: To assess the tomographic features of myopic choroidal neovascularization by spectral-domain optical coherence tomography. Methods: We consecutively reviewed the charts of patients with pathologic myopia, recent visual acuity deterioration and active macular neovascularization. Specific tomographic changes were studied in 25 eyes by two authors independently. Results: The mean age of patients eligible for the study was 63.4 (±18.2) years. Main tomographic outcomes were the hyperreflectivity of the lesion in 88% of cases (95% CI 0.74-1.02), absence of the external limiting membrane in 88% (95% CI 0.84-1.02), and retinal thickening in 83% (95% CI ...

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      Mentions: Luisa Pierro
    20. Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach

      Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach

      Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach. The principle investigator is Mona Garvin. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. This Career Development Award-2 (CDA-2) is for supporting an early-career engineering faculty member for three years. It will provide the means to train a young researcher currently possessing broad image analysis experience and narrowly focused expertise in one ophthalmic imaging modality (optical coherence tomography, OCT) in a multitude of ophthalmic modalities and clinical areas, with a special focus on glaucoma ...

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    21. Wavefront Error Correction with Adaptive Optics in Diabetic Retinopathy

      Wavefront Error Correction with Adaptive Optics in Diabetic Retinopathy

      Purpose: To determine the effects of diabetic retinopathy (DR), increased foveal thickness (FT), and adaptive optics (AO) on wavefront aberrations and Shack-Hartmann (SH) image quality. Methods: Shack-Hartmann aberrometry and wavefront error correction were performed with a bench-top AO retinal imaging system in 10 healthy control and 19 DR subjects. Spectral domain optical coherence tomography was performed and central FT was measured. Based on the FT data in the control group, subjects in the DR group were categorized into two subgroups: those with normal FT and those with increased FT. Shack-Hartmann image quality was assessed based on spot areas, and high-order ...

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    22. Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease

      Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease

      Spectral-domain Optical coherence tomography (OCT) has shown remarkable utility in the study of retinal disease and has helped to characterize the fovea in Parkinson disease (PD) patients. We developed a detailed mathematical model based on raw OCT data to allow differentiation of foveae of PD patients from healthy controls. Of the various models we tested, a difference of a Gaussian and a polynomial was found to have "the best fit". Decision was based on mathematical evaluation of the fit of the model to the data of 45 control eyes versus 50 PD eyes. We compared the model parameters in the ...

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