1. Articles in category: Ophthalmology

    553-576 of 9081 « 1 2 ... 21 22 23 24 25 26 27 ... 377 378 379 »
    1. Measurements of donor endothelial keratoplasty lenticules prepared from fresh donated whole eyes by using ultrasound and optical coherence tomography

      Measurements of donor endothelial keratoplasty lenticules prepared from fresh donated whole eyes by using ultrasound and optical coherence tomography

      This study was conducted to analyze the profile and thickness of endothelial keratoplasty lenticules prepared from fresh donated whole eyes with Visante optical coherence tomography (V-OCT) compared to measurements obtained from ultrasound pachymetry (USP) at the Central Eye Bank of Iran. Microkeratome-assisted precut corneas were prepared for Descemet stripping automated endothelial keratoplasty by using standard eye bank protocol. Central posterior lenticule thickness (CPLT) on fresh whole eye, before excising corneoscleral disc and transferring to Optisol-GS, was measured by USP. V-OCT was used to measure central, paracentral, and midperipheral thicknesses of lenticules after transferring the tissue to Optisol-GS. Chi Square and ...

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    2. EN FACE OPTICAL COHERENCE TOMOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME

      EN FACE OPTICAL COHERENCE TOMOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME

      Purpose: To report novel en face imaging findings of multiple evanescent white dot syndrome. Methods: A 25-year-old woman presented with photopsia and vision loss affecting the left eye. Ophthalmic examination, color fundus photography, fluorescein angiography, spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence, en face OCT, and OCT angiography were performed. Results: The diagnosis of multiple evanescent white dot syndrome was made based on clinical examination and multimodal imaging findings. Fundus autofluorescence demonstrated numerous hyperautofluorescent spots that corresponded to multifocal areas of ellipsoid loss with SD-OCT. En face OCT illustrated multiple small round hyperreflective "dots" at the level of the ...

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    3. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS

      Purpose: To evaluate the spectrum of macular chorioretinal lesions occurring in idiopathic multifocal choroiditis using optical coherence tomography angiography (OCTA) to evaluate those showing neovascular flow. Methods: This was a descriptive, retrospective study of 18 eyes of 14 patients with multifocal choroiditis. Macular lesions were characterized as subretinal pigment epithelium, subretinal, or mixed and evaluated during active and presumed inactive states of multifocal choroiditis. Correlations between structural optical coherence tomography and OCTA were performed. In select cases, correlations between OCTA, fluorescein angiography, and fundus autofluorescence were evaluated. In 5 eyes, quantitative measurements of neovascular lesions were compared at baseline and ...

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    4. Choroidal neovascularization secondary to Best vitelliform macular dystrophy detected by optical coherence tomography angiography

      Choroidal neovascularization secondary to Best vitelliform macular dystrophy detected by optical coherence tomography angiography

      Best vitelliform macular dystrophy (VMD) is a hereditary condition that causes childhood-onset macular dystrophy. In rare cases, VMD is accompanied by formation of a choroidal neovascular membrane (CNVM). We report a case of CNVM secondary to Best VMD in a 10-year-old boy that was detected using optical coherence tomography angiography, a new noninvasive diagnostic modality that detects motion contrast in repeated B-scans to identify blood flow within vessels.

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    5. Preoperative optical coherence tomography visualization of epiretinal membranes enhances surgical strategies

      Preoperative optical coherence tomography visualization of epiretinal membranes enhances surgical strategies

      Purpose: The aim of this study was to evaluate the usefulness of preoperative optical coherence tomography (OCT) findings in patients with macular epiretinal membrane (ERM) for the planning of surgical strategy. Patients and methods: One hundred twenty-three eyes of 121 patients (49 men, 72 women; mean age, 66 years) with an idiopathic ERM were enrolled. All patients underwent an ophthalmic examination including indirect ophthalmoscopy and OCT (Cirrus HD-OCT 4000 and/or 5000). OCT images obtained using model 4000 were transferred to the model 5000 system for vitreoretinal interface (VRI) analysis. The retinal thickness in each area, occurrence rate, and locations ...

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    6. Retinal vessel calibre measurements by optical coherence tomography angiography

      Retinal vessel calibre measurements by optical coherence tomography angiography

      Purpose To compare the vessel calibre measurements between optical coherence tomography angiography (OCTA) and colour fundus photography. Methods In this retrospective comparative study, OCTA and colour fundus images of healthy eyes and eyes with optic atrophy were evaluated. The colour fundus image was registered manually using Image J software to the OCTA image of the optic disc. Two independent graders measured the vessel calibre of the widest vein and artery in each peripapillary quadrant on a 3.4 mm diameter circle centred on the optic disc in the same location on both images. The difference in vessel calibre between the ...

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    7. ZEISS receives the first US FDA Clearance for Swept-Source OCT posterior ocular imaging with PLEX Elite 9000

      ZEISS receives the first US FDA Clearance for Swept-Source OCT posterior ocular imaging with PLEX Elite 9000

      Having received the first US FDA Clearance for OCT Angiography technology in September 2015, the Medical Technology business group of ZEISS now announces receiving the first US FDA Clearance for Swept-Source OCT imaging technology for posterior ocular structures with ZEISS PLEX ® Elite 9000. This powerful, cutting-edge Swept-Source OCT and OCT Angiography platform was designed for advanced retina research and is at the core of the Advanced Retina Imaging (A R I) Network 1 . The A R I Network, led by Philip J. Rosenfeld, MD, PhD, is a unique global consortium of clinicians and scientists from around the world working at ...

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    8. Associated factors for visibility and width of retrobulbar subarachnoid space on swept-source optical coherence tomography in high myopia

      Associated factors for visibility and width of retrobulbar subarachnoid space on swept-source optical coherence tomography in high myopia

      Subarachnoid space (SAS) around optic nerve can be visible with swept-source optical coherence tomography (SS-OCT). However, the relevant factors for its visibility and width have not been reported. In this prospective study, 193 eyes with high myopia were evaluated by SS-OCT. The relationship between age, gender, axial length, optic disc area, parapapillary atrophy (PPA) area, peripapillary choroidal thickness with the visibility and width of SAS were assessed. The results showed that SAS was observed in 125 (64.8%) and not observed in 68 (35.2%) eyes. Visibility of SAS is associated with long axial length, high myopia, thin choroid, large ...

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    9. Peripapillary Capillary Dilation in Leber Hereditary Optic Neuropathy Revealed by Optical Coherence Tomographic Angiography

      Peripapillary Capillary Dilation in Leber Hereditary Optic Neuropathy Revealed by Optical Coherence Tomographic Angiography

      Leber hereditary optic neuropathy (LHON) is caused by mitochondrial mutations that lead to sequential, subacute vision loss with incomplete penetrance and variable expressivity. 1 The most common mutations involve complex I subunits of the electron transport chain causing an energy production-demand mismatch that preferentially affects retina ganglion cells. The fundus can show only subtle vascular changes or appear normal, posing a diagnostic challenge in the acute phase of the disease.

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    10. CORRELATION OF MICROVASCULAR STRUCTURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY WITH VISUAL ACUITY IN RETINAL VEIN OCCLUSION

      CORRELATION OF MICROVASCULAR STRUCTURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY WITH VISUAL ACUITY IN RETINAL VEIN OCCLUSION

      Purpose: To analyze the correlation of superficial and deep capillary plexuses using optical coherence tomography (OCT) angiography with visual acuity in eyes with retinal vein occlusion (RVO). Methods: We retrospectively reviewed the medical records of 33 patients with retinal vein occlusion (RVO; branch retinal vein occlusion in 21 patients, central retinal vein occlusion in 11 patients) and included 33 healthy subjects as a control group, who were evaluated by OCT angiography. The OCT angiography was performed on a 3 mm x 3-mm region centered on the fovea and parafoveal area. The foveal avascular zone (FAZ), and foveal and parafoveal vascular ...

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    11. CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To determine the correlation and agreement between swept-source optical coherence tomography angiography (SS-OCT-A) with fluorescein angiography (FA), indocyanine green angiography (ICGA) and spectral domain OCT (SD-OCT) in characterizing polypoidal choroidal vasculopathy (PCV) and in differentiating eyes with typical age-related macular degeneration (t-AMD). Methods: This study included 32 and 54 eyes with t-AMD and PCV, respectively, who underwent SS-OCT-A, SD-OCT, fluorescein angiography, and indocyanine green angiography. The images from these four techniques were compared. Results: On SS-OCT-A, flow signals with vascular network configuration were detected in 81.2% and 77.8% of eyes with t-AMD and PCV, respectively. 40.4 ...

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      Mentions: Tien Yin Wong
    12. Detecting macular disease with a biometry device using swept-source optical coherence tomography

      Detecting macular disease with a biometry device using swept-source optical coherence tomography

      We read with interest the article by Hirnschall et al. 1 reporting that the central 1.0 mm retinal scan obtained using a biometry device (IOLMaster 700, Carl Zeiss Meditec AG) with swept-source optical coherence tomography (SS-OCT) technology provided useful information on the status of the macula, although it could not replace a macular scan using a dedicated spectral-domain OCT (SD-OCT) device.

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    13. Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report

      Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report

      The ophthalmic manifestations of dengue fever include a visually impairing maculopathy, where patients are left with a central or paracentral relative scotoma. The authors present a case of a 26-year-old female patient returning from Thailand with unilateral reduction in visual acuity and a central scotoma associated with dengue fever. The authors report the use of the optical coherence tomography angiography (OCTA) as a noninvasive imaging platform to demonstrate its value in showing the persistent changes corresponding to the functional central scotoma in dengue-related maculopathy, which often cannot be visualized clinically or by standard OCT and fundus fluorescein angiography.

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    14. Optical Coherence Tomography Angiography Characteristics of Fovea in Residual Subfoveal Perfluorocarbon Liquid Eye

      Optical Coherence Tomography Angiography Characteristics of Fovea in Residual Subfoveal Perfluorocarbon Liquid Eye

      The authors report a case of optical coherence tomography angiography (OCTA) features of retina and choriocapillaris before and after the surgical removal of a subfoveal perfluorocarbon liquid (PFCL) bubble. Before the surgery, the fovea avascular zone (FAZ) of both superficial and deep inner retinal layers (SRL/DRL) dramatically enlarged. However, after the removal, the FAZ continually decreased in both layers, even becoming close to normal in size. The abnormal choriocapillaris dark areas were also undetectable. Before and after surgery, the angle of the maximum FAZ diameter constantly remained horizontal and within normal limit in the SRL, forming an oval-shaped FAZ.

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    15. Optical coherence tomography-based ophthalmic testing methods, devices and systems

      Optical coherence tomography-based ophthalmic testing methods, devices and systems

      In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be ...

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    16. Optimized device for swept source optical coherence domain reflectometry and tomography

      Optimized device for swept source optical coherence domain reflectometry and tomography

      Optimized device for swept source optical coherence domain reflectometry and tomography. In the coherence-optical device, light, with the aid of an interferometer, is used for distance-measuring and imaging purposes on reflecting and scattering areas of the human eye. The optimized device according to the invention consists of includes a tunable light source, matched to the sought-after measurement region ZOCT, with a resonator length LR, an interferometric measurement arrangement, a data capturing unit for capturing the light portions scattered back from the sample and a data processing unit. Here the resonator length LR of the tunable light source is matched not ...

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    17. Optical Coherence Tomography and Magnetic Resonance Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

      Optical Coherence Tomography and Magnetic Resonance Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

      Irreversible disability in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is largely attributed to neuronal and axonal degeneration, which, along with inflammation, is one of the major pathological hallmarks of these diseases. Optical coherence tomography (OCT) is a non-invasive imaging tool that has been used in MS, NMOSD, and other diseases to quantify damage to the retina, including the ganglion cells and their axons. The fact that these are the only unmyelinated axons within the central nervous system (CNS) renders the afferent visual pathway an ideal model for studying axonal and neuronal degeneration in neurodegenerative diseases. Structural magnetic ...

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    18. En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy

      En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy

      Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument. If available, additional en face OCT images and B-scans were analyzed at follow-up times beyond the 52-week period. Results A total of 37 eyes (27 patients) were ...

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    19. Association between OCT-based microangiography perfusion indices and diabetic retinopathy severity

      Association between OCT-based microangiography perfusion indices and diabetic retinopathy severity

      Aim To evaluate the association between retinal capillary non-perfusion and diabetic retinopathy (DR) severity using optical coherence tomography-based microangiography (OMAG). Methods 33 patients (51 eyes) with a history of diabetes underwent imaging with a 68 kHz Cirrus-5000 spectral domain OMAG prototype. Demographic and clinical characteristics were collected. The perfusion index (PI) was defined as per cent coverage of area by retinal vessels with flow, measured within a minimum of 6.8×6.8 mm 2 OMAG scan. The PI in each ETDRS zone was analysed using an automated algorithm. Univariate and multivariate analyses were used to determine the degree of ...

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    20. Comparison of choroidal thickness measurements between spectral-domain OCT and swept-source OCT in normal and diseased eyes

      Comparison of choroidal thickness measurements between spectral-domain OCT and swept-source OCT in normal and diseased eyes

      Purpose: Sub-foveal choroidal thickness (SFCT) is affected in many ocular diseases. The aim of this study was to compare SFCT measurements between Topcon 3D 2000 spectral-domain optical coherence tomography (SD-OCT) and Topcon swept-source OCT (SS-OCT), with different laser wavelengths, in normal and diseased populations. Materials and methods: This was a prospective, cross-sectional, noninterventional study including 27 normal volunteers and 27 participants with retinal disease. OCT scans were performed sequentially and under standardized conditions using both SD-OCT and SS-OCT. The OCT scans were evaluated by two independent graders. Paired t -tests and intraclass correlation coefficients (ICCs) were used to assess the ...

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    21. Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

      Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

      Purpose The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in eyes with nonexudative age-related macular degeneration (AMD). Design Cross-sectional study. Participants Patients with nonexudative AMD were prospectively enrolled in an SS-OCT imaging study at the Bascom Palmer Eye Institute. Methods On the same day, all participants underwent color, FAF, and IR fundus imaging, as well as imaging with a prototype Zeiss 100 kHz SS-OCT instrument (Carl Zeiss Meditec Inc, Dublin ...

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    22. Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Purpose To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. Design Cross-sectional observational clinical study. Participants Patients with iris lesions and healthy volunteers. Methods Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months. Main Outcome Measures OCT and OCTA images, qualitative evaluation of iris and tumor vasculature, and quantitative vessel density. Results One eye each of 8 normal volunteers and 9 patients with iris ...

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    23. Postdoctoral Researcher in Ophthalmic Imaging at NYU Langone Eye Center

      Postdoctoral Researcher in Ophthalmic Imaging at NYU Langone Eye Center

      The Ophthalmic Imaging Research Laboratory at the New York University is looking for a Postdoctoral Associate to join our multidisciplinary team of clinicians, engineers, software specialists, biostatisticians and trainees. The position will primarily be focused on development of advanced optical imaging approaches and novel applications of multimodal adaptive optics optical coherence tomography (OCT) and adaptive optics scanning laser ophthalmoscopy (SLO) including – but not limited to – their use in retinal diseases and glaucoma. We are searching for a creative and highly motivated researcher with an interest in clinical and pre-clinical applications of in vivo ophthalmic imaging techniques. Preference will be given ...

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    24. Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

      Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

      The biomechanical properties of the cornea play a critical role in forming vision. Diseases such as keratoconus can structurally degenerate the cornea causing a pathological loss in visual acuity. UV-A/riboflavin corneal collagen crosslinking (CXL) is a clinically available treatment to stiffen the cornea and restore its healthy shape and function. However, current CXL techniques do not account for pre-existing biomechanical properties of the cornea nor the effects of the CXL treatment itself. In addition to the inherent corneal structure, the intraocular pressure (IOP) can also dramatically affect the measured biomechanical properties of the cornea. In this work, we present ...

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