1. Articles in category: Ophthalmology

    553-576 of 10309 « 1 2 ... 21 22 23 24 25 26 27 ... 428 429 430 »
    1. Optical coherence tomography angiography in patients with diabetic retinopathy treated with anti-VEGF intravitreal injections: Case report

      Optical coherence tomography angiography in patients with diabetic retinopathy treated with anti-VEGF intravitreal injections: Case report

      Purpose: To present optical coherence tomography angiography (OCTA) features in patients with diabetic retinopathy (DR) at the baseline and in response to treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA in management of patients with DR. Methods: Retrospective case series showing primary outcomes of 3 patients with DR and diabetic macular edema. Patients were injected intravitreally a loading phase of 3 monthly 2.0 mg aflibercept, followed by 2 injections bimonthly (5 injections in total). Before each injection OCTA was performed using 3 mm × 3 mm scans (Optovue, XR Avanti). The obtained scans of the macula were ...

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      Mentions: Optovue
    2. Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography

      Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography

      To compare the optical coherence tomography angiography (OCT-A) findings of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in eyes with pseudophakic cystoid macular edema (PCME) with those of fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) and to compare PCME vascular density values of the SCP and DCP with those of healthy eyes. In this retrospective observational study, 13 eyes (12 patients) with PCME underwent comprehensive ophthalmologic examinations including visual acuity, FA, SD-OCT, and OCT-A. The vascular density of the SCP and DCP were measured using AngioAnalytics software in all PCME eyes and compared with 46 ...

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    3. Dense concentric circle scanning protocol for measuring pulsatile retinal blood flow in rats with Doppler optical coherence tomography

      Dense concentric circle scanning protocol for measuring pulsatile retinal blood flow in rats with Doppler optical coherence tomography

      The variability in the spatial orientation of retinal blood vessels near the optic nerve head (ONH) results in imprecision of the measured Doppler angle and therefore the pulsatile blood flow (BF), when those parameters are evaluated using Doppler OCT imaging protocols based on dual-concentric circular scans. Here, we utilized a dense concentric circle scanning protocol and evaluated its precision for measuring pulsatile retinal BF in rats for different numbers of the circular scans. An spectral domain optical coherence tomography (SD-OCT) system operating in the 1060-nm spectral range with image acquisition rate of 47,000 A-scans/s was used to acquire ...

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    4. Retinal and Choroidal Changes in Patients with Parkinson’s Disease Detected by Swept-Source Optical Coherence Tomography

      Retinal and Choroidal Changes in Patients with Parkinson’s Disease Detected by Swept-Source Optical Coherence Tomography

      Purpose : To evaluate the ability of new Swept source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with Parkinson’s disease (PD). Design : Observational case–control cross sectional study, developed from January to May 2016. Methods : In total, 50 eyes from 50 patients diagnosed with PD and 54 eyes of 54 healthy controls underwent retinal and choroidal assessment using SS DRI Triton OCT (Topcon), using the 3D Wide protocol. Total macular thickness and peripapillary data (retinal, ganglion cell layer [GCL+, GCL++] and retinal nerve fiber layer [RNFL] thickness) were analyzed. Macular and ...

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    5. How OCT can help a smaller practice

      How OCT can help a smaller practice

      Spectral domain optical coherence tomography (SD-OCT) is rapidly becoming a must-have device for optometrists. OCT is the standard of care for detecting diabetic macular edema and is the fastest, least invasive method for detecting fluid in the retina. 1-4 It has also become a game-changer for monitoring macular degeneration, glaucoma, and diabetic retinopathy. 5-7 ODs in smaller practices may have the challenge of justifying the expense of this technology.

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    6. Heidelberg Engineering Invites Clinicians to Configure Their Own SPECTRALIS at AAO 2017

      Heidelberg Engineering Invites Clinicians to Configure Their Own SPECTRALIS at AAO 2017

      Heidelberg, Germany – The company’s latest products and advancements will be shown at booth 1029 at the American Academy of Ophthalmology Annual Meeting in New Orleans, LA, November 11-14. At this year’s AAO, Heidelberg Engineering will demonstrate how the various imaging modalities available for the SPECTRALIS® can be combined to suit the needs of an individual practice. The platform offers options including high resolution OCT2, MultiColor, BluePeak autofluorescence, widefield and ultra-widefield imaging, and scanning laser angiography. “The flexibility and upgradeability of the SPECTRALIS allow it to meet the diagnostic imaging needs of all types of clinical practices, regardless of ...

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    7. OCT power package reveals subsurface details during ophthalmic surgery

      OCT power package reveals subsurface details during ophthalmic surgery

      Leica Microsystems introduces the EnFocus intrasurgical OCT system in combination with the Proveo 8 surgical microscope to enhance ophthalmic surgical visualization Wetzlar, Germany. Leica Microsystems will debut the EnFocus intrasurgical optical coherence tomography ( OCT ) system in combination with its leading Proveo 8 microscope platform at the American Academy of Ophthalmology (AAO) Annual Meeting 2017. The EnFocus OCT system supplements the microscope view with real-time, en face visualization of subsurface ocular tissues to aid ophthalmologists with intrasurgical decision-making. “Through close collaboration with leading ophthalmic surgeons, we are convinced that OCT will soon become a standard of care in the ophthalmic OR ...

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    8. Segmented swept source optical coherence tomography angiography assessment of the perifoveal vasculature in patients with X-linked juvenile retinoschisis: a serial case report

      Segmented swept source optical coherence tomography angiography assessment of the perifoveal vasculature in patients with X-linked juvenile retinoschisis: a serial case report

      Purpose: To describe perifoveal microvascular changes occurring in X-linked juvenile retinoschisis (XLRS) using swept source optical coherence tomography angiography (SS OCTA). Patients and methods: This is a serial case report of three patients. Retrospective data of patients affected by XLRS were collected. Structural optical coherence tomography (OCT) and color fundus photography (CFPh) were carried out with Topcon ® OCT 2000 3D OCT as part of the standard care. Two patients were imaged on Topcon Atlantis ® SS OCTA and one on Topcon Triton ® SS OCTA. SS OCTA images were acquired using the 3 × 3 mm fovea-centered cubes scanning protocol. Analysis of both ...

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    9. Peripapillary retinal nerve fibre layer as measured by optical coherence tomography is a prognostic biomarker not only for physical but also for cognitive disability progression in multiple sclerosis

      Peripapillary retinal nerve fibre layer as measured by optical coherence tomography is a prognostic biomarker not only for physical but also for cognitive disability progression in multiple sclerosis

      Background: Peripapillary retinal nerve fibre layer (pRNFL) thickness is emerging as a marker of axonal degeneration in multiple sclerosis (MS). Objective: We aimed to prospectively assess the predictive value of pRNFL for progression of physical and cognitive disability in relapsing-remitting MS (RRMS). Methods: In this 3-year longitudinal study on 151 RRMS patients, pRNFL was measured by spectral-domain optical coherence tomography (OCT). We used proportional hazard models, correcting for age, sex, disease duration, Expanded Disability Status Scale (EDSS) and Symbol Digit Modalities Test (SDMT) at baseline, to test a pRNFL thickness ≤88 µm at baseline for prediction of EDSS progression and ...

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    10. Multimodal Evaluation of the Fellow Eye of Patients with Retinal Angiomatous Proliferation

      Multimodal Evaluation of the Fellow Eye of Patients with Retinal Angiomatous Proliferation

      Introduction: We conducted a multimodal, cross-sectional evaluation. Methods: Eyes were divided into 4 study groups: controls, early/intermediate age-related macular degeneration (AMD), fellow eyes of retinal angiomatous proliferation (RAP), and RAP eyes. Patients were evaluated with spectral-domain optical coherence tomography (OCT), enhanced depth imaging-OCT, and OCT angiography (OCTA). OCTA images were processed to generate maps of the vessel density and perfusion density of the superficial and deep retinal layers (SRL and DRL) and the choriocapillaris level (CL). The thickness of the outer nuclear layer and choroid was manually assessed. Results: We included 135 eyes of 100 patients (51 controls, 30 ...

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    11. Optical Coherence Tomography Angiography in Neuro-Ophthalmology

      Optical Coherence Tomography Angiography in Neuro-Ophthalmology

      Optical coherence tomography (OCT) has become the most commonly performed imaging procedure in ophthalmology (1,2). Conventional OCT provides high-resolution structural information of the retina and optic nerve. More recent functional extensions such as Doppler OCT (3) and OCT angiography (OCTA) (4) have emerged as useful tools for vascular evaluation of eye diseases, including optic neuropathies. This issue of the Journal of Neuro-Ophthalmology has 2 articles (5,6) demonstrating the utilization of OCTA in the evaluation of 2 different types of optic neuropathy. Here, we put these reports in the context of overall applications of OCT and OCTA in neuro-ophthalmology ...

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    12. Interocular Symmetry of Choroidal Thickness and Volume in Healthy Eyes on Optical Coherence Tomography

      Interocular Symmetry of Choroidal Thickness and Volume in Healthy Eyes on Optical Coherence Tomography

      Background: We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS). Methods: One hundred and fifty-four eyes of 77 healthy young adults between the ages of 19 and 32 years were enrolled. Differences in choroidal thickness (CT) and volume (CV) between the left and right eyes were calculated. Normal ranges of absolute interocular differences were established as the 95th percentile. Results: The mean ± SD subfoveal CT (SFCT) and total CV values in the right and left eyes were ...

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    13. En Face Optical Coherence Tomography of Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

      En Face Optical Coherence Tomography of Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

      A woman in her 60s presented with 2 months of blurred vision in the left eye, with visual acuity of 20/40. Examination of the left ocular fundus revealed spokelike foveal cysts. Fluorescein angiography showed no foveal leakage. En face optical coherence tomography (Optovue Inc) in the left eye revealed stellate hyporeflectivity ( Figure , A). A retinal cross-section scan revealed foveomacular retinoschisis involving the outer plexiform layer ( Figure , B). The fellow eye was normal. Without evidence of X-linked retinoschisis, niacin or taxane use, enhanced S-cone syndrome, glaucoma, traction, optic pit, or pathologic myopia, the patient was diagnosed as having stellate nonhereditary ...

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    14. Swept-Source Optical Coherence Tomography Angiography Findings in Torpedo Maculopathy

      Swept-Source Optical Coherence Tomography Angiography Findings in Torpedo Maculopathy

      Torpedo maculopathy is a rare congenital anomaly of the retinal pigment epithelium (RPE). Various imaging modalities have been used to assess cases of torpedo maculopathy, including optical coherence tomography (OCT) and fundus autofluorescence (FAF). OCT angiography (OCTA) offers combined structural and flow characteristics of imaged lesions. The authors present OCTA findings in two cases of torpedo maculopathy. Common features include loss of RPE and choriocapillaris allowing greater visualization of larger vessels in the outer choroid. This confirms the potential of OCTA to provide greater detail of retinal and choroidal architecture and elucidate the histopathology of retino-choridal lesions.

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    15. Optical Coherence Tomography Angiography of Two Choroidal Nevi Variants

      Optical Coherence Tomography Angiography of Two Choroidal Nevi Variants

      Optical coherence tomography angiography (OCT-A) is a recently established noninvasive technology for evaluation of the retinal and choroidal vasculature. The literature regarding the findings in choroidal nevi is scarce. We report the OCT-A findings associated with two different variants. Subject one had decreased vascular flow signal in the choroidal, choriocapillaris, deep retinal, and superficial retinal layers. Subject two had decreased vascular flow signal in the choroidal, choriocapillaris, and deep retinal layers with a normal vascular flow signal in the superficial retinal layer. To our knowledge, these patterns of decreased vascular flow signals have not been previously reported using OCT-A. This ...

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    16. Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study

      Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study

      Purpose: To study vitreoretinal interface (VRI) abnormalities in diabetic macular edema (DME) and the influence of these on the effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) therapy. Methods: VRI status and central retinal thickness (CRT) were evaluated using line and 3D-reference scans obtained using spectral domain-optical coherence tomography RTVue-100 before and 1 month after intravitreal anti-VEGF injection (IVI). VRI status was categorized into five subgroups: normal VRI, retinal surface wrinkling associated with the eccentric epiretinal membrane (ERM), ERM involving the macular center, vitreomacular adhesion (VMA), and vitreomacular traction (VMT). Results: A total of 105 eyes of 89 patients were ...

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    17. OCT screening in internal medicine increases disease detection

      OCT screening in internal medicine increases disease detection

      It is no surprise that patients without a significant refractive error may wait until their 50s or even 60s before obtaining a comprehensive eye exam. Presbyopia in an emmetrope in some cases is a curse because it can be treated with store-bought reading glasses for decades. Jerome Sherman Some of the top glaucoma specialists in both optometry and ophthalmology now recommend optical coherence tomography screenings on everyone beginning at age 40. Glaucoma specialist George Cioffi, MD, chairman of the department of ophthalmology at Columbia University in New York, stated at the SUNY Glaucoma Symposium earlier this year that he supports ...

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    18. Method and system for low coherence interferometry

      Method and system for low coherence interferometry

      Optical Coherence Tomography (OCT) system and apparatus of this instant application is very useful for diagnosis and management of 3ophthalmic diseases such as retinal diseases and glaucoma etc. Instant innovative OCT diagnostic system leverages advancements in cross technological platforms. The Michelson interferometric system presented in this application could be used for the OCT imaging, which includes biological OCT imaging, medical OCT imaging, ophthalmic OCT imaging, corneal OCT imaging, retinal OCT imaging, and the like. A tunable filter is placed in front of the detector to make the interferometer more sensitive and accurate for examining various samples for diagnosis.

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    19. Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]

      Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]

      Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human retina, GCs remain elusive due to their high optical translucency. Failure of conventional imaging—using predominately singly scattered light—to reveal GCs has led to a focus on multiply-scattered, fluorescence ...

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    20. Clinical findings supported by new OCTA technology

      Clinical findings supported by new OCTA technology

      A 67-year-old male who was the victim of blunt trauma to the right eye 50 years earlier attended for a periodic examination. He was new to the area and admitted to a family history of glaucoma. His medical history was remarkable only for several uneventful surgical procedures. He took no medications except vitamin supplements. A decade ago he had cataract extraction with intraocular lens (IOL) implantation and subsequent YAG-capsulotomy in the right eye. 

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