1. Articles in category: Ophthalmology

    553-576 of 7549 « 1 2 ... 21 22 23 24 25 26 27 ... 313 314 315 »
    1. Cleveland Clinic Receives NIH Grant to Study Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives NIH Grant to Study Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives a 2015 NIH Grant for $203,124 to Study Intraoperative Optical Coherence Tomography for Ophthalmic Surgery. The principal investigatgor is Justis Ehlers. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Optical coherence tomography (OCT) has revolutionized the management of ophthalmic diseases with the precise anatomic information it provides with non-invasive imaging. The high-resolution cross-sectional tissue details make OCT a natural complement to ophthalmic surgery. Intraoperative OCT (iOCT) has the potential to provide real-time feedback to surgeons thus improving surgical care and outcomes. This research activity will focus on ...

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    2. Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography

      Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography

      Presented here are new processing techniques for optical coherence tomography (OCT) data that allow for improved visualization and use of full-range OCT images. These techniques minimize the central line artifact and the complex conjugate artifact without requiring additional system hardware or significantly increasing post-processing time. The central line artifact is minimized by normalizing each A-scan to account for ripples at the zero-delay position. The complex conjugate artifact is minimized by segmentation of a layer or layers that cross the zero-delay position, and in some embodiments by further segmentation of other surfaces based on the segmentation of the initial layer or ...

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    3. Microscope Integrated Intraoperative Spectral Domain Optical Coherence Tomography for Cataract Surgery: Uses and Applications

      Microscope Integrated Intraoperative Spectral Domain Optical Coherence Tomography for Cataract Surgery: Uses and Applications

      Aim : To demonstrate the uses and applications of a microscope integrated intraoperative Optical Coherence Tomography in Micro Incision Cataract Surgery (MICS) and Femtosecond Laser Assisted Cataract Surgery (FLACS). Methods : Intraoperative real time imaging using the RESCAN™ 700 (Carl Zeiss Meditec, Oberkochen, Germany) was done for patients undergoing MICS as well as FLACS. The OCT videos were reviewed at each step of the procedure and the findings were noted and analyzed. Results : Microscope Integrated Intraoperative Optical Coherence Tomography was found to be beneficial during all the critical steps of cataract surgery. We were able to qualitatively assess wound morphology in clear ...

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    4. Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression

      Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression

      Previous reports of ocular abnormalities in Huntington’s disease (HD) have detailed eye movement disorders. The objective of this case–control study was to investigate optic nerve and macular morphology in HD using optical coherence tomography (OCT). A total of 26 HD patients and 29 controls underwent a thorough ophthalmic examination including spectral domain OCT scans of the macula and peripapillary retinal nerve fibre layer (RNFL). Genetic testing results, disease duration, HD disease burden scores and Unified HD Rating Scale motor scores were acquired for HD patients. Temporal RNFL thickness was significantly reduced in the HD group (62.3 vs ...

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    5. Optical Coherence Tomography Findings and Visual Outcome after Treatment with Intravitreal Bevacizumab in Parafoveal Telangiectasia

      Optical Coherence Tomography Findings and Visual Outcome after Treatment with Intravitreal Bevacizumab in Parafoveal Telangiectasia

      Methods: A prospective interventional study of 40 patients (80 eyes) with bilateral parafoveal telengectiasis. They were divided into three groups. Group 1 which included 15 patients with PFT were under observation and treated conservatively. Group 2 included 14 patients with PFT complicated by cystoid macular oedema who were treated with intravitreal injection of bevacizumab each (0.1 ml) under aseptic conditions. Group 3 included 11 patients with PFT and choroidal neovascular membranes who were treated with intravitreal injections of bevacizumab. In the three groups pre interventional and post interventional visual acuities were recorded. Pre and post intervention macular thickness was ...

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    6. Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

      Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

      Importance New methods are needed to compare peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements taken from time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT). Objective To compare the agreement of measured and predicted pRNFLT using different equations based on pRNFLT measurements obtained by TD-OCT and SD-OCT. Design, Setting, and Participants Cross-sectional single-center study that took place at the Department of Ophthalmology, University of Erlangen–Nuremberg from November 16, 2005, to June 3, 2015, and included 138 eyes of control participants, 126 eyes of patients with ocular hypertension, 128 eyes of patients with preperimetric glaucoma, and 160 eyes of ...

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    7. Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Purpose: To assess the repeatability and reproducibility of corneal power values obtained by a Fourier-domain optical coherence tomography (FD-OCT) system (RTVue) and to compare them with the values obtained by a Scheimpflug camera system (Pentacam HR) and by automated keratometry (IOL Master). Methods: Thirty-two eyes from 32 healthy subjects were included in this prospective study. Two experienced observers measured each eye 3 consecutive times with the Pentacam, IOLMaster, and RTVue centered on either the pupil or corneal vertex. The conventional keratometry equivalent (CKE) and anterior (Ka), posterior (Kp), and net (Kn) corneal power values were determined. Results: The corneal power ...

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    8. Determination of Feasibility and Utility of Microscope-Integrated Optical Coherence Tomography During Ophthalmic Surgery The DISCOVER Study RESCAN Results

      Determination of Feasibility and Utility of Microscope-Integrated Optical Coherence Tomography During Ophthalmic Surgery The DISCOVER Study RESCAN Results

      Importance Optical coherence tomography (OCT) has transformed the clinical management of a myriad of ophthalmic conditions. Applying OCT to ophthalmic surgery may have implications for surgical decision making and patient outcomes. Objective To assess the feasibility and effect on surgical decision making of a microscope-integrated intraoperative OCT (iOCT) system. Design, Setting, and Participants Report highlighting the 1-year results (March 2014–February 2015) of the RESCAN 700 portion of the DISCOVER (Determination of Feasibility of Intraoperative Spectral Domain Microscope Combined/Integrated OCT Visualization During En Face Retinal and Ophthalmic Surgery) study, a single-site, multisurgeon, prospective consecutive case series regarding this investigational ...

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    9. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI (n=113) or standard PCI (n=75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8-9.4 ...

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    10. Flecks in Recessive Stargardt Disease: Short-Wavelength Autofluorescence, Near-Infrared Autofluorescence, and Optical Coherence Tomography

      Flecks in Recessive Stargardt Disease: Short-Wavelength Autofluorescence, Near-Infrared Autofluorescence, and Optical Coherence Tomography

      Purpose : We evaluated the incongruous observation whereby flecks in recessive Stargardt disease (STGD1) can exhibit increased short-wavelength autofluorescence (SW-AF) that originates from retinal pigment epithelium (RPE) lipofuscin, while near-infrared AF (NIR-AF), emitted primarily from RPE melanin, is usually reduced or absent at fleck positions. Methods : Flecks in SW- and NIR-AF images and spectral-domain optical coherence tomography (SD-OCT) scans were studied in 19 STGD1 patients carrying disease-causing ABCA4 mutations. Fleck spatial distribution and progression were recorded in serial AF images. Results : Flecks observed in SW-AF images typically colocalized with darkened foci in NIR-AF images; the NIR-AF profiles were larger. The decreased ...

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    11. Intraoperative Optical Coherence Tomography Ocular Surgery on a Higher Level or Just Nice Pictures?

      Intraoperative Optical Coherence Tomography Ocular Surgery on a Higher Level or Just Nice Pictures?

      In recent years, optical coherence tomography (OCT) has developed into one of the most important imaging techniques in ophthalmology. Nonetheless, this technology is still evolving rapidly as recent developments in multimodal swept-source OCT devices and 4-dimensional real-time OCT demonstrate. Another currently developing sector in OCT application is the intraoperative use of OCT technology. Several approaches have been used to transfer OCT into an intraoperative setting, beginning with OCT-compatible positioning of the anesthetized patient 1 and handheld OCT devices. 2

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    12. Comparison of Laser Scanning Diagnostic Devices for Early Glaucoma Detection

      Comparison of Laser Scanning Diagnostic Devices for Early Glaucoma Detection

      B Background: To compare the diagnostic accuracy and to evaluate the correlation of optic nerve head and retinal nerve fiber layer thickness values between Fourier-Domain optical coherence tomography (FD-OCT), confocal scanning laser ophthalmoscopy (CSLO), and scanning laser polarimetry (SLP) for early glaucoma detection. Patients and Methods: Ninety-three patients with early open-angle glaucoma, 58 patients with ocular hypertension, and 60 healthy control subjects were included in this observational, cross-sectional study. All study participants underwent FD-OCT (RTVue-100), CSLO (HRT3), and SLP (GDx VCC) imaging of the optic nerve head and the retinal nerve fiber layer. Area under the receiver operating characteristic curves ...

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    13. Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

      Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

      Background To explore the changes in thickness in different areas and layers of the macula under different refractive conditions. Methods Consecutive participants were enrolled in the study. Optical coherence tomography (OCT) images were obtained using a spectral-domain system. We studied the relationships of the full, inner and outer retinal thicknesses of the fovea, parafovea and perifovea relative to the spherical equivalent (SE) and axial length (AL). Results We included 107 eyes; the analysis revealed that the men had thicker foveas (man vs women: 236.70 ± 18.97 μm vs 247.25 ± 16.70 μm P  = 0.002) and inner parafoveas ...

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    14. Systems And Methods For Eye Tracking For Motion Corrected Ophthalmic Optical Coherenece Tomography

      Systems And Methods For Eye Tracking For Motion Corrected Ophthalmic Optical Coherenece Tomography

      Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot at a pupil plane for image capture and during capture of the OCT images. The imaging system also includes a controller configured to control the scanner to relocate the OCT ...

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    15. Optical Coherence Tomography (OCT) System With Improved Motion Contrast

      Optical Coherence Tomography (OCT) System With Improved Motion Contrast

      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly relates to motion contrast methods for such OCT systems.

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    16. The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation

      The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation

      Recent Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography research software can quantify the thickness of each individual retinal layer. There is a suggestion that the macular ganglion cell layer (GCL) and ganglion cell complex may be more sensitive for detecting glaucoma than the peripapillary retinal nerve fiber layer (pRNFL). The purpose of this study was to characterize/compare the thickness of each macular layer among children with glaucoma versus normals.

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    17. Pediatric spectral domain optical coherence tomography (SD-OCT) normative data for novel optic nerve parameters using the Heidelberg Spectralis

      Pediatric spectral domain optical coherence tomography (SD-OCT) normative data for novel optic nerve parameters using the Heidelberg Spectralis

      SD-OCT normative data for optic nerve volume (ONV) and the peripapillary papillomacular bundle thickness have not been reported, yet these parameters are relevant for neuro-ophthalmic disease. The purpose of this study was to determine pediatric norms for these parameters and expand the dataset for typical OCT parameters.

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    18. Reproducibility of retinal nerve fiber layer thickness measures using eye-tracking with spectral-domain optical coherence tomography in children with optic neuropathy

      Reproducibility of retinal nerve fiber layer thickness measures using eye-tracking with spectral-domain optical coherence tomography in children with optic neuropathy

      To determine the intra- and intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) thickness measures using eye-tracking-assisted spectral domain optical coherence tomography (SD-OCT) in children with nonglaucomatous optic neuropathy.

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    19. Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length

      Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length

      Purpose: Doppler optical coherence tomography (OCT) is widely used for measuring retinal blood flow. Existing Doppler OCT methods require the eyeball axial length, in which empirical values are usually used. However, variations in the axial length can create a bias unaccounted for in the retinal blood flow measurement. The authors plan to develop a Doppler OCT method that can measure the total retinal blood flow rate without requiring the eyeball axial length. Methods: The authors measured the retinal blood flow rate using a dual-ring scanning protocol. The small and large scanning rings entered the eye at different incident angles (small ...

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    20. Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction

      Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction

      Purpose: To evaluate optical coherence tomography meibography (OCT-M) in patients with and without obstructive meibomian gland dysfunction (MGD) and to determine the relationship between OCT-M and ocular surface clinical tests. Methods: Twenty-two patients with MGD and 16 control subjects were included. Each patient underwent an evaluation of ocular surface disease symptoms, lid margin abnormality score, lipid layer thickness evaluation, and meibomian gland (MG) morphological changes using noncontact infrared meibography and OCT-M. OCT-M scans were acquired in 4 different locations. OCT-M parameters including the MG length and width and palpebral conjunctival thickness were evaluated. Results: Within the OCT-M parameters, the mean ...

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      Mentions: Ningli Wang
    21. Longitudinal Evaluation of Cornea With Swept-Source Optical Coherence Tomography and Scheimpflug Imaging Before and After Lasik

      Longitudinal Evaluation of Cornea With Swept-Source Optical Coherence Tomography and Scheimpflug Imaging Before and After Lasik

      Abstract: Swept-source optical coherence tomography (OCT) is the latest advancement in anterior segment imaging. There are limited data regarding its performance after laser in situ keratomileusis (LASIK). We compared the reliability of swept-source OCT and Scheimpflug imaging for evaluation of corneal parameters in refractive surgery candidates with myopia or myopic astigmatism. Three consecutive measurements were obtained preoperatively and 1 year postoperatively using swept-source OCT and Scheimpflug imaging. The study parameters included central corneal thickness (CCT), thinnest corneal thickness (TCT), keratometry at steep (Ks) and flat (Kf) axes, mean keratometry (Km), and, anterior and posterior best fit spheres (Ant and Post ...

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    22. Rowe Technical Design, Inc. announces that Whole Model Eye for OCT (Tissue Phantom) is now in production!

      Rowe Technical Design, Inc. announces that Whole Model Eye for OCT (Tissue Phantom) is now in production!

      Rowe Technical Design, Inc. (RTD), developers of the 1st commercial optical tissue phantom for OCT, announces that their latest version of the Whole Model Eye complete with Cornea, Crystalline Lens and Retina tissue phantoms for OCT has now been released for full serial production. “We’re excited because this is our third serial production model eye, following up on the very successful anterior chamber and OCT model eyes with retina tissue phantom” notes T. Scott Rowe, company founder and president. “We are extremely pleased with the customer feedback so far, and we are ready for serial production. This is the ...

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      Mentions: T. Scott Rowe
    23. Analysis of Choroidal Thickness Measured Using RTVue and Associated Factors in Open-Angle Glaucoma

      Analysis of Choroidal Thickness Measured Using RTVue and Associated Factors in Open-Angle Glaucoma

      Purpose To compare the macular choroidal thickness, ganglion cell complex thickness, peripapillary choroidal thickness and retinal nerve fiber layer thickness among normal, primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients using RTVue (Fourier-domain optical coherence tomography; Optovue, Fremont, CA, USA). Methods A retrospective analysis of 32 normal controls, 32 POAG and 52 NTG patients was performed. Choroidal thickness, ganglion cell complex thickness and retinal nerve fiber layer thickness were compared among normal controls, POAG and NTG subjects. Additionally, the factors influencing choroidal thickness (age, axial length, spherical equivalent, central corneal thickness, mean deviation, nocturnal dip, blood pressure ...

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    24. Spectral-Domain Optical Coherence Tomography Findings of Vogt-Koyanagi-Harada Disease

      Spectral-Domain Optical Coherence Tomography Findings of Vogt-Koyanagi-Harada Disease

      Purpose To report characteristics of Vogt-Koyanagi-Harada (VKH) disease as observed on spectral-domain optical coherence tomography (SD-OCT) images. Case summary (Case 1) A 38-year-old female presented with visual impairment in both eyes. On fundus examination, multifocal serous retinal detachment in the posterior pole was observed in both eyes. On enhanced SD-OCT, serous retinal detachment and cystoid macular edema in the outer retina were observed and the intraretinal fluid space was divided by a membranous structure forming an intraretinal compartmentalized cystic space. Under the diagnosis of VKH disease, the patient was treated with intravenous administration of methylprednisolone. After treatment, enhanced SD-OCT images ...

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