1. Articles in category: Ophthalmology

    553-576 of 5611 « 1 2 ... 21 22 23 24 25 26 27 ... 232 233 234 »
    1. Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

      Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

      Purpose: To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT). Methods: RNFL thickness and optic disc parameters were obtained in 65 patients aged 50.1 ± 7.7 years. Percentage differences in all parameters were calculated and analyzed between groups. Results: The mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes ( P < 0.01). The greatest decrease in RNFL thickness was observed at the inferior (39.5%) and superior (39.3%) quadrants and at ...

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    2. MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation

      MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation

      Purpose: To describe the spectrum of pigment epithelial detachments (PEDs) occurring mainly in age-related macular degeneration and central serous chorioretinopathy and also in other inflammatory, neoplastic and iatrogenic, retinal, and systemic disorders. Methods: Pigment epithelial detachments are divided into drusenoid, serous, vascularized, or mixed categories. Results: The clinical presentation, classification, and natural history of PEDs are reviewed as illustrated with multimodal imaging combining traditional and novel imaging techniques, including fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and spectral domain optical coherence tomography. Most PEDs occur because of pathophysiologic mechanisms taking place below the retinal pigment epithelium that are difficult to ...

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      Mentions: K. Bailey Freund
    3. Optic Disc Drusen in a Child: Diagnosis Using Noninvasive Imaging Tools

      Optic Disc Drusen in a Child: Diagnosis Using Noninvasive Imaging Tools

      Purpose: To describe a case of bilateral optic nerve head drusen (ONHD) in a pediatric patient and the complementary use of advanced noninvasive imaging techniques to confirm this diagnosis. Case Report: A 15-year-old female adolescent with type 1 diabetes and no ocular history was seen at a routine screening without complaints. Visual acuity was 20/20 bilaterally, and visual fields using frequency doubling technology (Zeiss Humphrey Systems, Dublin, CA) were within normal limits. Fundus photography (CX-1 Mydriatic/Non-Mydriatic Hybrid Digital Retinal Camera, Canon, Toyko, Japan) showed slight elevation of the left disc margin, with lack of physiologic cup, elevation of ...

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    4. High resolution OCT quantitative analysis of the space between the IOL and the posterior capsule during the early cataract post-operative period

      High resolution OCT quantitative analysis of the space between the IOL and the posterior capsule during the early cataract post-operative period

      Purpose: To quantitatively characterize the space between the intraocular lens (IOL) and the posterior capsule (IOL-PC space) during the early post-phacoemulsification period, using high resolution optical coherence tomography (OCT). Methods: Thirty eyes of 30 patients who underwent phacoemulsification were recruited and randomly divided into two groups. Acrysof Natural IQ IOLs were implanted in one group (n = 15), and Adapt-AO IOLs were implanted into the other (n = 15). A custom built OCT instrument was used to image the IOL-PC space at 1 day, 1 week, and 1 month after surgery. Slit-lamp examination and auto refraction were performed at each visit. Results ...

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    5. Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography

      Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography

      Purpose. To analyze microstructural changes in the external limiting membrane (ELM) and photoreceptor layer before and after early and late conventional laser treatment in central serous chorioretinopathy (CSC) in 12 months follow-up study. Methods. A retrospective observational study included Group A: 19 patients (19 eyes) with symptomatic acute CSC and Group B: 16 patients (16 eyes) with symptomatic chronic CSC. Retinal microstructural changes were analyzed with SD-OCT paying a particular role in examining the photoreceptor layer and ELM. Results.The length of the photoreceptors, prior to treatment, was approximately 84

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    6. Imaging in retina units: changes observed during the last 12 years

      Imaging in retina units: changes observed during the last 12 years

      Purpose: The last decade has seen many improvements in the imaging of the choroids, retina, and vitreous. However, there are no available data about changes in the practice of imaging in retina units. The present study was therefore undertaken to document the 12-year changes in this practice in retina units in France, particularly the relative changes in the distribution of the different imaging methods. Methods: This retrospective study was performed in 4 different retina units considered to be representative of retina units in France. They comprise 2 departments of ophthalmology in university-based hospitals in Paris and Nantes, one in a ...

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    7. Choroidal changes by ocular coherence tomography in white dot syndrome

      Choroidal changes by ocular coherence tomography in white dot syndrome

      Purpose To evaluate the findings of optical coherence tomography (OCT) in the acute and convalescent stages in patients with white dot syndrome. Patients were followed up at our clinic for at least 6 months. Materials and methods A consecutive case series of patients with white dot syndrome were enrolled in this study. Only patients with disease onset less than 1 week were included in this study. Slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, indocyanine green angiography (ICGA), OCT, visual field test, and corrected decimal visual acuity test were performed on all patients. Results A total of eight eyes from eight patients ...

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    8. Characteristic Findings of Optical Coherence Tomography in Retinal Angiomatous Proliferation

      Characteristic Findings of Optical Coherence Tomography in Retinal Angiomatous Proliferation

      Purpose To identify the unique pathologic findings of retinal angiomatous proliferation (RAP) in optical coherence tomography (OCT). Methods Retrospectively, 29 eyes of 25 patients with age-related macular degeneration and complicated RAP were analyzed. All 29 eyes had choroidal neovascularization (CNV) in the area of pigment epithelial detachment (PED) or adjacent to it, which was visible with fluorescein angiography or indocyanine green angiography. Cross-sectional images were obtained by OCT scanning through the CNV lesions. Results Six distinctive findings of OCT included drusen (100%), inner retinal cyst (80%), outer retinal cyst (68%), fibrovascular PED (84%), serous retinal detachment (40%), and PED (68 ...

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    9. Preoperative and Postoperative Optical Coherence Tomography Findings in Patients with Rhegmatogenous Retinal Detachment Involving the Macular Region

      Preoperative and Postoperative Optical Coherence Tomography Findings in Patients with Rhegmatogenous Retinal Detachment Involving the Macular Region

      Purpose . To evaluate morphologic changes of the macula, we observed eyes with rhegmatogenous retinal detachment (RRD) involving the macular region by optical coherence tomography (OCT). Subjects and Methods . We studied 26 eyes with RRD before and after surgery, assessing visual acuity, the height of retinal detachment at the fovea (HRD), and morphologic changes of the macular region. The interval between the onset and surgery was also determined. We examined the external limiting membrane (ELM) after surgery and the continuity of the inner segment-outer segment junction (IS/OS junction) of the photoreceptor layer. Results . Impairment of visual acuity was observed when ...

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    10. Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT

      Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT

      Custom high-resolution high-speed anterior segment spectral domain Optical Coherence Tomography (OCT) provided with automatic quantification and distortion correction algorithms was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo in four subjects, for accommodative demands between 0 to 6 D in 1 D steps. Anterior and posterior lens radii of curvature decreased with accommodative demand at rates of 0.73 and 0.20 mm/D, resulting in an increase of the estimated optical power of the eye of 0.62 D per diopter of accommodative demand. Dynamic fluctuations in crystalline lens radii of curvature, anterior chamber depth and ...

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    11. Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Background: Patients with multiple sclerosis (MS) demonstrate thinning of peripapillary retinal nerve fiber layer (RNFL) and decreased macular volume as measured by optical coherence tomography (OCT). To our knowledge, there are no previous reports from a large MS OCT database with strict quality control measures that quantitate RNFL and macula in patients with relapsing-remitting multiple sclerosis. Methods: The University of California Davis OCT Reading Center gathered OCT data at baseline as part of the North American phase 3 trial of fingolimod (Gilenya). Average RNFL thickness (RNFLT) and macular volume (TMV) were measured using time domain OCT (TD-OCT). RNFL quadrants, clock ...

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    12. Retinal silicone oil emulsification found with SD-OCT

      Retinal silicone oil emulsification found with SD-OCT

      According to recent data small hyperreflective areas found intraretinally, subretinally and underneath the epiretinal membranes with spectral domain optical coherence tomography (SD-OCT) could be small bubbles of emulsified silicone. In this study, the authors (Dr Marie-Hélène Errera et al. , Moorfields Eye Hospital, London, UK, and Centre Hospitalier National des Quinze-Vingts, Paris, France) performed a retrospective case study on 11 eyes of 11 patients. Patients who had undergone vitrectomy and silicone oil tamponade whose SD-OCT imaging had shown silicone oil emulsion manifestations were identified. Out of these 11 patients, 9 had undergone treatment as a result of rhegmatogenous retinal ...

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    13. Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography

      Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography

      Purpose: To investigate the optical intensities of all retinal layers on 3D spectral domain optical coherence tomography (SD-OCT) in normal subjects using an automatic measurement. Methods: Forty normal subjects underwent Topcon 3D-OCT 1000 macula-centered scan. The raw data was automatically segmented into 10 layers using the 3D graph search approach. Then the mean and standard deviation of intensities of each layer were calculated. The image quality index was given by the OCT software. Correlation analysis was performed between the optical intensities in each layer with the image quality and subject's age. Results: The correlation of optical intensities was strong ...

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    14. In Vivo Three-Dimensional Corneal Epithelium Imaging in Normal Eyes by Anterior-Segment Optical Coherence Tomography: A Clinical Reference Study

      In Vivo Three-Dimensional Corneal Epithelium Imaging in Normal Eyes by Anterior-Segment Optical Coherence Tomography: A Clinical Reference Study

      Purpose: To evaluate the safety and efficacy of real-time measurement of corneal epithelial thickness and investigate the distribution characteristics in a large normal-eye population using a clinically available spectral-domain anterior-segment optical coherence tomography (AS OCT) system. Methods: Corneal epithelial thickness distribution and topographic thickness variability were clinically investigated using AS OCT imaging in 373 patients with normal, healthy eyes. Descriptive statistics investigated 3 sets of subgroups, male (n = 171) and female (n = 202), younger (n = 194) and older (n = 179), right eyes (n = 195) and left eyes (n = 197). Results: Pupil center epithelial thickness repeatability was an average 0.88 ...

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    15. Retina-simulating phantom for optical coherence tomography

      Retina-simulating phantom for optical coherence tomography

      Optical coherence tomography (OCT) is a rapidly growing imaging modality, particularly in the field of ophthalmology. Accurate early diagnosis of diseases requires consistent and validated imaging performance. In contrast to more well-established medical imaging modalities, no standardized test methods currently exist for OCT quality assurance. We developed a retinal phantom which mimics the thickness and near-infrared optical properties of each anatomical retinal layer as well as the surface topography of the foveal pit. The fabrication process involves layer-by-layer spin coating of nanoparticle-embedded silicone films followed by laser micro-etching to modify the surface topography. The thickness of each layer and dimensions ...

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    16. Evaluation of the Retina of Subjects Without Diabetes Mellitus and Subjects With Diabetes Mellitus Without Diabetic Retinopathy Using Optical Coherence Tomography

      Evaluation of the Retina of Subjects Without Diabetes Mellitus and Subjects With Diabetes Mellitus Without Diabetic Retinopathy Using Optical Coherence Tomography

      The purpose of this study is to evaluate topographic features of the posterior pole of the eye in normal subjects as well as in subjects with diabetes mellitus but without diabetic retinopathy (DR) usingoptical coherence tomography (OCT). The investigators proposal is a novel study to determine retinal volume of normal and diabetic subjects without DR. Specifically, the investigators will establish a standardized reference range for retinal thickness and volume that will provide standards for OCT analysis of different clinical trials for retinal diseases.

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    17. Optical coherence tomography findings in spinocerebellar ataxia-3

      Optical coherence tomography findings in spinocerebellar ataxia-3

      Purpose To report optical coherence tomography (OCT) findings in order to detect subclinical alterations of the afferent visual pathways in spinocerebellar ataxia 3 (SCA-3). Patients and methods Nine genetically confirmed patients (18 eyes) were evaluated with a complete ophthalmologic examination including visual acuity, colour vision, visual field test, and retinal nerve fibre layer (RNFL) and macular thickness with OCT Cirrus HD. A neurological examination was performed and the Scale for the Assessment and Rating of Ataxia (SARA score) was determined in all patients. Results The mean RNFL thickness was 77.39 microns, standard deviation (SD) was ±5.93. In 15 ...

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    18. Calibration of histological retina specimens after fixation in Margo’s solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography

      Calibration of histological retina specimens after fixation in Margo’s solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography

      Background The extent of retinal tissue deformation by histological processing needs to be separately measured for every workup protocol. This work presents a simple approach for its quantitative assessment, and shows lateral and axial scaling factors for a common protocol. We calibrated histological measurements by in-vivo photographic and optical coherence tomographic (OCT) measurements, using retinal photocoagulation lesions as calibration markers. Methods We evaluated four rabbit eyes that were examined histologically after fixation in Margo’s solution (1 % paraformaldehyde:1.25 % glutaraldehyde), isopropanol dehydration, paraffin embedding and hematoxylin and eosin staining. Distances between 51 pairs of laser lesions were compared in ...

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    19. Optical coherence reflectometry with depth resolution

      Optical coherence reflectometry with depth resolution

      A device for performing distance measurements on an eye. The device includes an interferometer, focuses at least one measurement beam records backscattered radiation and interferometrically generates a measurement signal displaying structures of the eye by time-domain, spectral-domain or Fourier-domain coherence reflectometry, has an adjustment apparatus for laterally and/or axially displacing the focus in the eye or for varying a polarization state of the measurement beam and has a control apparatus which actuates the interferometer, wherein the control apparatus generates a plurality of A-scan individual signals from the backscattered radiation, combines these to an A-scan measurement signal and actuates the ...

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    20. Feature Of The Week 9/15/13: Longitudinal Fundus and Retinal Studies with SD-OCT: A Comparison of Five Mouse Inbred Strains

      Feature Of The Week 9/15/13: Longitudinal Fundus and Retinal Studies with SD-OCT: A Comparison of Five Mouse Inbred Strains

      The mouse is a well established model for studying hereditary disorders, which have an effect on eye structure and function, including frequently occurring degenerative retinal diseases, such as retinitis pigmentosa. However, many of these retinal disorders remain to be characterized functionally to understand the underlying mechanisms and develop strategies for therapeutic intervention. Recently, a commercial third-generation SD-OCT system (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) was adapted for high-resolution in vivo imaging of the mouse fundus and retinal morphology. This system has successfully been implemented into the first-line phenotyping of the German Mouse Clinic I (GMC I; www.mouseclinic.de) as ...

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    21. Changes in Optical Coherence Tomography Findings in Acute Zonal Occult Outer Retinopathy

      Changes in Optical Coherence Tomography Findings in Acute Zonal Occult Outer Retinopathy

      Purpose: To report a case of acute zonal occult outer retinopathy (AZOOR) in a 39-year-old woman. Methods: Images were obtained with fundus photography and optical coherence tomography (OCT). A multifocal electroretinogram (mfERG) was also obtained to evaluate retinal function. Results: The patient's right visual acuity was 0.8. Fundus photographs showed no specific abnormal findings. OCT showed attenuation of the photoreceptor inner segment/outer segment (IS/OS) line and the cone outer segment tip (COST) line in the right eye. The mfERG showed corresponding amplitude reductions. One month after the initial visit, her right visual acuity improved to 1 ...

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    22. Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography

      Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography

      Aqueous leaves the anterior chamber of eye by passing through the trabecular meshwork (TM), a tissue thought to be responsible for increased outflow resistance in glaucoma. Motion assessment could permit characterization of TM biomechanical properties necessary to maintain intra-ocular pressure (IOP) within a narrow homeostatic range. In this paper, we report the first in vivo identification of TM motion in humans. We use a phase-sensitive optical coherence tomography (PhS-OCT) system with sub-nanometer sensitivity to detect and image dynamic pulse-induced TM motion. To permit quantification of TM motion and relationships we develop and apply a phase compensation algorithm permitting removal of ...

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    23. Assessing the effects of ketorolac and acetazolamide on macular thickness by optical coherence tomography following cataract surgery

      Assessing the effects of ketorolac and acetazolamide on macular thickness by optical coherence tomography following cataract surgery

      We aimed to evaluate the efficacy of topical ketorolac 0.5 % solution and oral acetazolamide 250 mg/day delivery during the first month after uneventful phacoemulsification surgery by measuring the macular thickness using optical coherence tomography. Our nonmasked randomized prospective study comprised 87 eyes of 80 patients. Complete follow-up was achieved on 84 eyes of 77 eligible patients. Postoperatively, the patients were divided into three groups. One group received ketorolac 0.5 %, the other group received acetazolamide 250 mg/day, and the control group was given no agent. Macular thickness and volume were measured at 1 week and 1 month ...

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