1. Articles in category: Ophthalmology

    553-576 of 6246 « 1 2 ... 21 22 23 24 25 26 27 ... 259 260 261 »
    1. Spectral-domain optical coherence tomography evaluation of the cornea, retina, and optic nerve in normal horses

      Spectral-domain optical coherence tomography evaluation of the cornea, retina, and optic nerve in normal horses

      Purpose To determine the feasibility of using a handheld spectral-domain optical coherence tomography (SD-OCT) instrument to characterize normal corneal, retinal, and optic nerve head anatomy in vivo in standing horses. Methods Clinically normal horses under sedation, palpebral nerve blockage, and pharmacologically induced mydriasis were imaged with a SD-OCT instrument (Envisu SD-OCT, Bioptigen, Inc., Morrisville, NC). Radial volumes from the cornea (axial, superior, inferior, nasal, and temporal), and rectangular volumes from the retina (dorsal, ventral, nasal, and temporal) and optic nerve head were acquired. Manual measurements of the corneal layers within the five regions, retinal and nerve fiber layer thickness in ...

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    2. Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy

      Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy

      Importance Birdshot chorioretinopathy (BCR) is a bilateral posterior uveitis that typically requires aggressive therapy to prevent loss of vision. Clinical signs of disease activity may be subtle and visual acuity is often preserved despite significant loss of visual function. Optical coherence tomography with enhanced depth imaging (OCT-EDI), a new technology that allows visualization of structures posterior to the retinal pigment epithelium, may be a useful tool to monitor disease activity in these patients. Objective To determine the correlation between symptoms and signs of disease activity in BCR and specific findings on OCT-EDI. Design, Setting, and Participants Retrospective medical record review ...

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    3. Objective Measurement of Vitreous Inflammation Using Optical Coherence Tomography

      Objective Measurement of Vitreous Inflammation Using Optical Coherence Tomography

      Purpose To obtain measurements of vitreous signal intensity from optical coherence tomography (OCT) image sets in patients with uveitis, with the aim of developing an objective, quantitative marker of inflammatory activity in patients with this disease. Design Retrospective, observational case-control series. Participants Thirty patients (30 eyes) with vitreous haze secondary to intermediate, posterior, or panuveitis; 12 patients (12 eyes) with uveitis but without evidence of vitreous haze; and 18 patients (18 eyes) without intraocular inflammation or vitreoretinal disease. Methods Clinical and demographic characteristics were recorded, including visual acuity (VA), diagnosis, and anatomic type of uveitis. In each eye, the anterior ...

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    4. Comparison of Optical Coherence Tomography Assessments in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Comparison of Optical Coherence Tomography Assessments in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Objective To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD). Design Cross-sectional study within the Comparison of AMD Treatments Trials (CATT). Participants During year 2 of CATT, 1213 pairs of SD OCT and TD OCT scans were compared from a subset of 384 eyes. Methods Masked readers independently graded OCT scans for presence of intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid and performed manual measurements of retinal, SRF, and subretinal tissue complex thicknesses at the foveal center ...

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    5. Spectral domain optical coherence tomography imaging of spectacular ecdysis in the royal python (Python regius)

      Spectral domain optical coherence tomography imaging of spectacular ecdysis in the royal python (Python regius)

      Objective To describe using spectral domain optical coherence tomography (SD-OCT), digital slit-lamp biomicroscopy, and external photography, changes in the ophidian cuticle, spectacle, and cornea during ecdysis. Animals Studied Four normal royal pythons ( Python regius) . Procedures Snakes were assessed once daily throughout a complete shed cycle using nasal, axial, and temporal SD-OCT images, digital slit-lamp biomicroscopy, and external photography. Results Spectral domain optical coherence tomography (SD-OCT) images reliably showed the spectacular cuticle and stroma, subcuticular space (SCS), cornea, anterior chamber, iris, and Schlemm's canal. When visible, the subspectacular space (SSS) was more distended peripherally than axially. Ocular surface changes throughout ...

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      Mentions: UC Davis
    6. Optical Coherence Tomography (OCT) Device Independent Intraretinal Layer Segmentation

      Optical Coherence Tomography (OCT) Device Independent Intraretinal Layer Segmentation

      Purpose: To develop and test an algorithm to segment intraretinal layers irrespectively of the actual Optical Coherence Tomography (OCT) device used. Methods: The developed algorithm is based on the graph theory optimization. The algorithm's performance was evaluated against that of three expert graders for unsigned boundary position difference and thickness measurement of a retinal layer group in 50 and 41 B-scans, respectively. Reproducibility of the algorithm was tested in 30 C-scans of 10 healthy subjects each with the Spectralis and the Stratus OCT. Comparability between different devices was evaluated in 84 C-scans (volume or radial scans) obtained from 21 ...

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    7. Scattering coefficients of mice organs categorized pathologically by spectral domain optical coherence tomography

      Scattering coefficients of mice organs categorized pathologically by spectral domain optical coherence tomography

      Differences in tissue density cause a variety of scattering coefficients. To quantify optical coherence tomography (OCT) images for diagnosis, the tissue's scattering coefficient is estimated by curve fitting the OCT signals to a confocal single backscattering mode. The results from a group of 30 mice show that the scattering coefficients of bone, skin, liver, brain, testis, and spleen can be categorized into three groups: a scattering coefficient between 1.947 and 2.134 mm −1 : bone and skin; a scattering coefficient between 1.303 and 1.461 mm −1 : liver and brain; a scattering coefficient between 0.523 and ...

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    8. An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

      An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

      Background Recently it was shown that retinal vessel diameters could be measured using spectral domain optical coherence tomography (OCT). It has also been suggested that retinal vessels manifest different features on spectral domain OCT (SD-OCT) depending on whether they are arteries or veins. Our study was aimed to present a reliable SD-OCT assisted method of differentiating retinal arteries from veins. Methods Patients who underwent circular OCT scans centred at the optic disc using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels for subsequent grading ...

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    9. Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis

      Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis

      Aims To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS). Methods Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS −ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms. Results The mean ONH FI was 0.160±0.010 for the HC group ...

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    10. Non-invasive assessment of retinal alterations in mouse models of infantile and juvenile neuronal ceroid lipofuscinosis by spectral domain optical coherence tomography

      Non-invasive assessment of retinal alterations in mouse models of infantile and juvenile neuronal ceroid lipofuscinosis by spectral domain optical coherence tomography

      Introduction The neuronal ceroid lipofuscinoses constitute a group of fatal inherited lysosomal storage diseases that manifest in profound neurodegeneration in the CNS. Visual impairment usually is an early symptom and selective degeneration of retinal neurons has been described in patients suffering from distinct disease subtypes. We have previously demonstrated that palmitoyl protein thioesterase 1 deficient (Ppt1-/-) mice, a model of the infantile disease subtype, exhibit progressive axonal degeneration in the optic nerve and loss of retinal ganglion cells, faithfully reflecting disease severity in the CNS. Here we performed spectral domain optical coherence tomography (OCT) in Ppt1-/- and ceroid lipofuscinosis neuronal ...

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    11. Fundus photographing apparatus

      Fundus photographing apparatus

      An ophthalmic photographing apparatus includes an optical coherence tomography device provided to imaging a tomographic image of an examinee's eye. The device includes: an irradiation position changing unit for changing an irradiation position of measurement light emitted from a light source on the eye to change an imaging position on the eye; and a detector for detecting a interference state between the measurement light reflected from the eye and reference light, and a displacement detecting unit provided to detect displacement in continuity between a tomographic image having already been obtained in a first imaging region and a tomographic image ...

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      Mentions: Nidek Toshio Murata
    12. Intraocular lenses and Japan tax hike drive Meditec growth

      Intraocular lenses and Japan tax hike drive Meditec growth

      In his letter to shareholders, Monz also highlighted the recent introduction of the first ophthalmic surgery microscope to feature an integrated optical coherence tomography (OCT) camera as evidence of the company’s ongoing innovation. “The unique combination of two established Zeiss gold standards means we can now offer surgeons more comprehensive visualization during surgery, which enables better treatment results,” Monz wrote. Fierce competition in diagnostics Though growing fast, the surgical ophthalmology business unit remains Meditec’s smallest, accounting for €73.4 million of sales in the six months to the end of March. Multifocal and premium toric lenses developed recently ...

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    13. Feature Of The Week 4/11/14: Virtual Reality Simulator for Vitreoretinal Surgery using Integrated OCT Data

      Feature Of The Week 4/11/14: Virtual Reality Simulator for Vitreoretinal Surgery using Integrated OCT Data

      Its clear that OCT is playing increasingly important role in integrated surgical devices. There are numerous research and clinical papers that have been recently published and there are several innovative companies that have products in this area including Zeiss, Bioptigen, LenSx, Optimedica, and others. Its natural that virtual reality simulators would play a role in training surgeons to uses these tools. Recently researchers from King Khaled Eye Specialist Hospital and University of Illinois College of Engineering published preliminary results on this topic as shown below. Operative practice using surgical simulators has become a part of training in many surgical specialties ...

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    14. The Safer Method of Sub-Tenon’s Bevacizumab Injection with Central Serous Chorioretinopathy: A Noninvasive Evaluation by Series of Optic Coherence Tomography

      The Safer Method of Sub-Tenon’s Bevacizumab Injection with Central Serous Chorioretinopathy: A Noninvasive Evaluation by Series of Optic Coherence Tomography

      To evaluate the outcome of patients with central serous chorioretinopathy (CSCR) after deep sub-tenon bevacizumab injection by the noninvasive evaluation by optic coherence tomography (OCT). Methods: Three patients having CSCR with moderate to severe vision loss were treated with at least two time of sub-tenon bevacizumab injection (0.3 ml). All the patients underwent the complete examinations at the baseline and follow-up visits. This ocular evaluation included the bare and best-corrected visual acuity (by Snellen chart), fundus biomicroscopy and OCT in each visit. Results: The follow-up point ranged between 2 and 6 months. Improvement of vision was observed, and they ...

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    15. Optical coherence tomographic assessment of retinal nerve fiber layer thickness changes before and after glaucoma filtration surgery

      Optical coherence tomographic assessment of retinal nerve fiber layer thickness changes before and after glaucoma filtration surgery

      Background: Glaucomatous Optic Neuropathy (GON) is very common in the glaucoma patients, and impaired effect of glaucoma is measured by the Retinal Nerve Fiber Layer (RNFL) thickness. Objective: The study was conducted to find out the mean RNFL thickness, RNFL thickness in different quadrants, Intra-Ocular Pressure (IOP) changes, and visual field changes after filtration surgery in different ages and genders using Optical Coherence Tomography (OCT). Materials and Methods: The study was an interventional case-series conducted at the Glaucoma Clinic at the Regional Institute of Ophthalmology at Kolkata from March 2009 to August 2010. Fifty-one eyes of 43 open angle glaucoma ...

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    16. Evaluation of Optic Nerve Development in Preterm and Term Infants Using Handheld Spectral-Domain Optical Coherence Tomography

      Evaluation of Optic Nerve Development in Preterm and Term Infants Using Handheld Spectral-Domain Optical Coherence Tomography

      Purpose To evaluate effects of prematurity on early optic nerve (ON) development and the usefulness of ON parameters as indicators of central nervous system (CNS) development and pathology. Design Prospective, cross-sectional, longitudinal study. Participants Forty-four preterm infants undergoing retinopathy of prematurity (ROP) screening and 52 term infants. Methods We analyzed ON from portable handheld spectral-domain optical coherence tomography (SD-OCT) images (Bioptigen, Inc, Research Triangle Park, NC) of 44 preterm and 52 term infants. The highest-quality ON scan from either eye was selected for quantitative analysis. Longitudinal analysis was performed at 31–36 weeks and 37–42 weeks postmenstrual age (PMA ...

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    17. Alcon, Carl Zeiss and Bausch & Lomb Lead the European Ophthalmic Device Market to Over €700 million by 2020

      Alcon, Carl Zeiss and Bausch & Lomb Lead the European Ophthalmic Device Market to Over €700 million by 2020

      According to a new report by iData Research ( http://www.idataresearch.com ), the leading global authority in medical device and pharmaceutical market research, the European diagnostic and interventional ophthalmic device market is expected to exceed €700 million by 2020. There are two main drivers fueling this market, technological innovation and the increasingly aging population that are affected with ocular diseases. As the population ages, the prevalence of ocular diseases such as cataracts and glaucoma increases. In addition, refractive problems such as myopia, hyperopia and astigmatism are more likely to occur in older people. These factors drive demand for specialized ophthalmic ...

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    18. Washington University Receives NIH Grant for Studying Mechanics of Early Brain and Eye Development

      Washington University Receives NIH Grant for Studying Mechanics of Early Brain and Eye Development

      Washington University Receives a 2014 NIH Grant for $332,591 for Studying Mechanics of Early Brain and Eye Development. The principle investigator is Larry Taber. The program beganin 2010 and ends in 2015. Below is a summary of the proposed work. In human embryos, the primary subdivisions of the brain (forebrain, midbrain, and hindbrain) are formed by the fourth week of gestation. During this time, the primitive eyes (optic vesicles) emerge as protrusions from the forebrain. The forms of these organs are highly conserved. Abnormalities in size and shape of the early brain are known to cause serious neurological disorders ...

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    19. University of Iowa Receiveds NIH Grant for Retinal Therapy Guided by 2-D OCT Imaging Analysis

      University of Iowa Receiveds NIH Grant for Retinal Therapy Guided by 2-D OCT Imaging Analysis

      University of Iowa Received a 2014 NIH Grant for $516,408 for Retinal Therapy Guided by 2-D OCT Imaging Analysis. The principle investigator is Milan Sonka. The program began in 2010 and ends in 2015. Below is a summary of the proposed work. Age related macular degeneration (AMD) is one of the primary causes of blindness in the U.S. A wealth of powerful new treatments, especially anti-VEGF agents, have recently become available to restore visual function in choroidal neovascularization (CNV), the most severe form of AMD. The risk of ocular adverse events increases with repeated intravitreal treatment injections. Ideally ...

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    20. University of Iowa Receives NIH Grant for 3D image Analysis Approach to Determine Severity and Cause of Optical Nerve Edema.

      University of Iowa Receives NIH Grant for 3D image Analysis Approach to Determine Severity and Cause of Optical Nerve Edema.

      University of Iowa Receives a 2014 NIH Grant for $332,955 for 3D image Analysis Approach to Determine Severity and Cause of Optical Nerve Edema. The principal investigator is Mona Garvin. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Currently, the clinical assessment of optic nerve swelling is limited by the subjective ophthalmoscopic evaluation by experts in order to diagnose and differentiate the cause of the optic disc edema. The long-term goal of our research effort is to develop automated 3D image-analysis approaches for the identification of an optimal set of ...

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    21. Agreement of Two Different Spectral Domain Optical Coherence Tomography Instruments for Retinal Nerve Fiber Layer Measurements

      Agreement of Two Different Spectral Domain  Optical Coherence Tomography Instruments for  Retinal Nerve Fiber Layer Measurements

      Purpose: To determine the agreement between Spectralis and Cirrus spectral domain optical coherence tomography (SD-OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) thickness. Methods: Suspected or confirmed cases of glaucoma who met the inclusion criteria underwent peripapillary RNFL thickness measurement using both the Spectralis and Cirrus on the same day within a few minutes. Results: Measurements were performed on 103 eyes of 103 patients with mean age of 50.4±17.7 years. Mean RNFL thickness was 89.22±15.87 versus 84.54±13.68 µm using Spectralis and Cirrus, respectively. The difference between measurements and the average ...

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    22. Spectral-domain optical coherence tomography epithelial and flap thickness mapping in femtosecond laser-assisted in situ keratomileusis

      Spectral-domain optical coherence tomography epithelial and flap thickness mapping in femtosecond laser-assisted in situ keratomileusis

      Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using Spectral-domain optical coherence tomography (SD-OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral eye study. Methods 40 myopic eyes underwent LASIK using the ALLEGRETTO ® Eye-Q excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25±1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 (IL) in one eye and WaveLight FS200 (FS) in the contralateral eye. SD-OCT (Optovue RTVue-100) was used to evaluate the epithelial and flap ...

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    23. Clinical and optic coherence tomography findings of focal choroidal excavation in Chinese patients

      Clinical and optic coherence tomography findings of focal choroidal excavation in Chinese patients

      Background To describe the clinical and optical coherence tomography (OCT) features of focal choroidal excavation in Chinese patients. Methods Retrospectively, thirty-seven eyes (in 31 patients) that demonstrated focal choroidal excavation on spectral-domain OCT were collected. Their clinical characteristics and other features were also collected and analyzed. Results In total, 42 focal choroidal excavations were identified in 31 patients, including 25 unilateral and 6 bilateral (37 eyes). The abnormal changes in these eyes with choroidal excavation were more prominent at the outer part of the neuro-retina, the retinal pigment epithelium (RPE) and the choroid. The average transverse diameter and depth of ...

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