1. Articles in category: Ophthalmology

    553-576 of 8580 « 1 2 ... 21 22 23 24 25 26 27 ... 356 357 358 »
    1. Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

      Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

      Purpose To analyze the macular structure in a large series of consecutive patients with different types of uveitis using spectral-domain optical coherence tomography (SD-OCT). Patients and methods Five hundred eyes of 500 consecutive patients with anterior, intermediate, posterior, and panuveitis underwent standardized macular examination using SD-OCT. Central retinal thickness (CRT), macular volume (MV), and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), epiretinal membrane with (ERM + ) and without (ERM−) retinal surface wrinkling were determined. Results The anatomic location of inflammation affected significantly CRT and MV (P<0.001, respectively), with the highest values in ...

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    2. ABSORPTION OF SUB-RETINAL FLUID UNDER-MACULA AFTER SCLERAL BUCKLING SURGERY FOR RHEGMATOGENOUS RETINAL DETACHMENT ON OPTICAL COHERENCE TOMOGRAPHY

      ABSORPTION OF SUB-RETINAL FLUID UNDER-MACULA AFTER SCLERAL BUCKLING SURGERY FOR RHEGMATOGENOUS RETINAL DETACHMENT ON OPTICAL COHERENCE TOMOGRAPHY

      Objective: To determine the incidence of sub-macular fluid by Optical Coherence Tomography (OCT) and its clinical consequences on visual acuity after apparently successful scleral buckling surgery in uncomplicated macula-off, rhegmatogenous retinal detachment. Study Design: Prospective observational cohort series. Material and Methods: This study was conducted at Institute of Ophthalmology, Mayo Hospital Lahore from February 2011 to July 2012. Total 54 patients of age above 20 years with uncomplicated, macula-off, rhegmatogenous RD of less than 1 month duration were selected after fulfilling inclusion and exclusion criteria. After informed consent, all patients underwent scleral buckling surgery with or without intra-operative external drainage ...

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    3. Morphological features in anterior scleral inflammation using swept-source optical coherence tomography with multiple B-scan averaging

      Morphological features in anterior scleral inflammation using swept-source optical coherence tomography with multiple B-scan averaging

      Background/aims To determine the morphological features of anterior scleral inflammation using swept-source optical coherence tomography. Methods In this retrospective observational study, we examined 17 eyes of 14 patients with diffuse anterior scleral inflammation and 13 eyes of 13 young unaffected patients. We compared cross-sectional images of the conjunctiva, episclera and sclera obtained using swept-source optical coherence tomography equipped with a multiple B-scan averaging process between normal eyes and those with episcleritis and scleritis. Results Optical coherence tomography showed that the conjunctival stroma/episclera layer was notably swollen in diseased eyes. The eyes with diffuse anterior scleral inflammation had a ...

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    4. Advanced OCT and Adaptive Optics Imaging in Retinal Disease (The ACAD Study)

      Advanced OCT and Adaptive Optics Imaging in Retinal Disease (The ACAD Study)

      The objectives of this study include using the new technology of SS-OCT (swept source optical coherence tomography ) to evaluate morphological abnormalities of the vitreous, retina and choroid and to assess the repeatability of retinal and choroidal thickness measurements in retinal disease using SS-OCT. A secondary objective is to use the new imaging modality of adaptive optics to directly visualize photoreceptor mosaics and microvasculature in eyes with retinal and choroidal disease.

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    5. Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

      Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

      Alzheimer’s disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic changes occur in visual function, including visual field defects, abnormal contrast sensitivity, abnormalities in color vision, depth perception deficits, and motion detection abnormalities. These visual changes were initially believed to be solely due to neurodegeneration in the posterior visual pathway. However, evidence from pathology studies in both animal models of ...

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    6. Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Purpose To describe the optical coherence tomography angiography (OCT-A) features of treatment-naïve quiescent choroidal neovascularization (CNV) secondary to age-related macular degeneration, and to estimate the detection rate for neovascularization by means of OCT-A. Design Diagnostic tool validity assessment. Methods Treatment-naïve quiescent CNV were identified from a pool of patients at 2 retina referral centers. Patients underwent a complete ophthalmologic examination including fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCT-A. Detection rates of CNV by means of OCT-A were estimated with a second cohort of patients without CNV (negative controls) Results Twenty-two eyes of 20 consecutive patients with ...

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    7. The NHS is exploring whether Google’s AI could help to save people’s eyesight

      The NHS is exploring whether Google’s AI could help to save people’s eyesight

      NHS eye hospital Moorfields has announced it is working with DeepMind — an artificial intelligence research lab acquired by Google in 2014 for a reported £400 million — in a bid to identify people who are likely to lose their sight as a result of an eye disease. Through the medical research partnership, Moorfields will investigate whether DeepMind’s AI technology can be used to help spot early signs of eye conditions that human eye care experts might miss. In order to determine whether DeepMind’s AI technology is useful for diagnosing eye conditions, Moorfields is applying the company’s algorithms to ...

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    8. Google DeepMind will use machine learning to spot eye diseases early (with Video)

      Google DeepMind will use machine learning to spot eye diseases early (with Video)

      Google's DeepMind is embarking on a new research project to help doctors spot the early signs of sight-threatening eye diseases. The company's British-based artificial intelligence division will use machine learning to analyze more than one million anonymous eye scans, creating algorithms that can detect early warning signs that humans might miss. The project is DeepMind's second collaboration with the UK's National Health Service (NHS), but the first to use artificial intelligence. DeepMind is hoping to spot two eye conditions in particular: wet age-related macular degeneration and diabetic retinopathy, the latter being the fastest growing cause of ...

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    9. Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $590,459 for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The human brain is made up of an array of functionally and structurally defined regions. Localizing these regions is critical for early diagnosis of an array of diseases such as Alzheimer's disease (AD), as well as for neuroscientific research aimed at understanding the brain's functional and structural properties and clinical intervention in drug-resistant depression ...

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    10. Swept Source optical coherence tomography of choroidal nevi

      Swept Source optical coherence tomography of choroidal nevi

      Objective The aim of this article is to report on retinal and choroidal morphology in choroidal nevi documented with Swept Source optical coherence tomography (SS-OCT). Design This is a retrospective, observational study. Participants We included 27 consecutive patients with choroidal nevi. Mean age was 66.3 years (21–95 years). Methods The SS-OCT scanning protocol consisted of a single line scan through the centre of the nevi with a resolution of 3 µm, built from 1024 A-scans, with a length of 12 mm. We attempted to visualize the outer choroidoscleral boundary and suprachoroidal layer (SCL) below the choroidal nevus and ...

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    11. Morphological changes after trabeculectomy in highly myopic eyes with high intraocular pressure by using swept-source optical coherence tomography

      Morphological changes after trabeculectomy in highly myopic eyes with high intraocular pressure by using swept-source optical coherence tomography

      Purpose To investigate the effects of intraocular pressure (IOP) reduction on the eyeball shape in highly myopic eyes with high IOP. Methods This study included patients with an axial length ≥26.5 mm and high IOP ≥22 mmHg after receiving maximum medication, with successful trabeculectomy by a single surgeon, and who underwent swept-source optical coherence tomography (SS-OCT) examinations on preoperative and postoperative ≥3 months periods. Eight eyes of 7 patients were included in the analysis. The morphological changes in the eyeball that occurred pre- and post-operation were analyzed from the SS-OCT images. Results In 6 out of 8 examined eyes ...

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    12. ULTRASOUND BIOMICROSCOPY AND ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY IN THE DIAGNOSIS AND MANAGEMENT OF GLAUCOMA

      ULTRASOUND BIOMICROSCOPY AND ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY IN THE DIAGNOSIS AND MANAGEMENT OF GLAUCOMA

      We aimed to summarize the applications, strengths and weaknesses of two anterior segment imaging modalities: the ultrasound biomicroscopy (UBM) and the anterior segment optical coherence tomography (AS-OCT) in the diagnosis and surgical management of glaucoma. This narrative review was based on our clinical experience with these technologies supported on scientific literature review through Medline via PubMed ® . The syntax used in the search was “Glaucoma AND Anterior Chamber Angle AND Ultrasound Biomicroscopy OR UBM AND Anterior Segment Optical Coherence Tomography OR AS-OCT”. Publications were selected based on relevance, redundancy, and authorship. Additionally UBM and AS-OCT images were selected from the two ...

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    13. The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

      The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

      Background Recent Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography (SD-OCT) research software can automatically quantify the thickness of each individual retinal layer. The macular ganglion cell layer (GCL) and ganglion cell complex may be more sensitive for detecting glaucoma than the peripapillary retinal nerve fiber layer (pRNFL). The aim of this study was to characterize and compare the volume of each macular layer in the eyes of children with glaucoma versus those of normal controls. Methods The medical records of children with primary glaucoma and physiologic cupping who had undergone Spectralis SD-OCT imaging of the macula and pRNFL were ...

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    14. Evaluation of Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Primary Craniopharyngioma by Fourier-Domain Optical Coherence Tomography

      Evaluation of Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Primary Craniopharyngioma by Fourier-Domain Optical Coherence Tomography

      BACKGROUND : The aim of this study was to compare the differences in macular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) in child and adult patients with primary craniopharyngioma by Fourier-domain optical coherence tomography (FD-OCT) and to evaluate their significance in the diagnosis of primary craniopharyngioma. MATERIAL AND METHODS : Ninety-six participants were divided into 3 groups: 32 in the child craniopharyngioma group (CCG) and 32 in the adult craniopharyngioma group (ACG) who were treated in Beijing Tiantan Hospital between November 2013 and October 2014, and 32 in the normal group (NG). All subjects were scanned by FD-OCT ...

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    15. The relationship between perifoveal achromatic, L- and M-cone acuity and retinal structure as assessed with multimodal high resolution imaging

      The relationship between perifoveal achromatic, L- and M-cone acuity and retinal structure as assessed with multimodal high resolution imaging

      The relationships between perifoveal measures of achromatic-, L- and M-cone acuity and retinal structure were investigated in healthy young males. Thirty-two males, aged 20–39 years, with normal foveal logMAR letter acuity and no observed ocular abnormalities participated in the study. Achromatic and isolated L- and M-cone spatial acuity was measured in the dominant eye with a Sloan E letter of 90% achromatic decrement contrast or 23% increment cone contrast, respectively. Separately, the central part of the same eye was imaged with high-resolution spectral-domain optical coherence tomography (SD-OCT) and adaptive optics ophthalmoscopy (AOO). Thickness measures and cone density in the ...

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    16. Comparison between Pentacam-HR and optical coherence tomographycentral corneal thickness measurements in healthy feline eyes

      Comparison between Pentacam-HR and optical coherence tomographycentral corneal thickness measurements in healthy feline eyes

      Objectives To measure the central corneal thickness (CCT) in healthy feline eyes with Scheimpflug imaging (Pentacam, Pentacam ® -HR) and to compare these values with those obtained with spectral-domain optical coherence tomography (OCT, Optovue ® iVue). Animals studied Thirty one sedated Domestic Short-haired cats. Procedures Two repeated CCT measurements were obtained from both eyes using Pentacam measured at the pupil center and corneal apex (CCT pupil and CCT apex ) and using SD-OCT (CCT OCT ). Agreement between the imaging modalities for CCT and intradevice repeatability was evaluated with Bland–Altman analysis. Mixed modeling was used to test for a difference between methods. Results ...

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    17. Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

      Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

      Retinitis pigmentosa (RP) is a progressive inherited retinal disease characterized by nyctalopia, visual field constriction, and reduced full-field electroretinograms. The progressive loss of photoreceptors leads to vision loss at the end stage of RP. The prevalence of RP is approximately 1/4,000. Since it is one of the major causes of visual impairment worldwide, morphological and functional assessments are useful for estimating the retinal structure and function in RP. Optical coherence tomography (OCT) is a well-established method of examining retinal structure in situ, and the obtained images by OCT help to analyze morphological abnormalities. Changes revealed by OCT have ...

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    18. Effects of Diabetic Macular Edema on Repeatability of Retinal Nerve Fiber Layer Thickness Measurements at the Macular and Peripapillary Area Using Swept-Source Optical Coherence Tomography

      Effects of Diabetic Macular Edema on Repeatability of Retinal Nerve Fiber Layer Thickness Measurements at the Macular and Peripapillary Area Using Swept-Source Optical Coherence Tomography

      Purpose : To investigate the repeatability of macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements made using swept-source optical coherence tomography (SS-OCT) and automated segmentation. Measurements were made in non-diabetic controls and in patients with diabetic retinopathy (DR) with or without diabetic macular edema (DME). Materials and Methods : A total of 131 eyes of 131 participants were included. Fifty-one eyes with DR had no DME (DME[–]), 45 eyes with DR had DME (DME[+]), and 35 eyes were healthy. Measurements of RNFL and full retinal thickness were simultaneously obtained with SS-OCT in the peripapillary area and in the nine Early ...

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    19. Real-Time Intraoperative Optical Coherence Tomography Imaging Confirms Older Concepts About the Berger Space

      Real-Time Intraoperative Optical Coherence Tomography Imaging Confirms Older Concepts About the Berger Space

      Background: The presence of a space between the posterior capsule and the anterior vitreous was first reported in 1887, but difficulties inherent in examining this structure made it impossible to visualize this area in vivo until now. Estimation of the size of this space was considered to be impossible. Materials and Methods: We utilized an optical coherence tomography (OCT) system attached to the Zeiss Opmi Lumera 700/Rescan microscope (Zeiss Ltd., Jena, Germany) to provide real-time images of the Berger space, the anterior hyaloid and the ligament of Wieger. Results: Imaging in 3 patients provided beautiful, real-time OCT images of ...

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    20. Anterior segment optical coherence tomography for identifying muscle status in strabismus surgery

      Anterior segment optical coherence tomography for identifying muscle status in strabismus surgery

      Dear Sir, Anterior segment optical coherence tomography (AS-OCT) finds very few indications in the domain of strabismus surgery. Current applications remain restricted to determining limbus-muscle insertion distance and anterior segment changes after strabismus surgery. We discuss two cases of operated strabismus surgery where AS-OCT imaging helped in identifying the operated eye and/or extra ocular muscles (EOM) and thus proved instrumental in planning and management. Case 1 A 45 years old orthotropic male presented with post traumatic left eye rhegmatogenous retinal detachment. He had history of strabismus surgery in the left eye in childhood for exotropia. He was planned for ...

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    21. Does the Stage of Keratoconus Affect Optical Coherence Tomography Measurements?

      Does the Stage of Keratoconus Affect Optical Coherence Tomography Measurements?

      Purpose : To employ optical coherence tomography (OCT) to examine the relationship of changes in the retinal nerve fiber layer (RNFL) and macular thickness as well as ganglion cell (GC) parameters with the stage of keratoconus (KC), and to compare these changes with a control group. Methods : A total of 84 eyes of 68 patients with KC and 29 eyes of 29 normal age-matched subjects underwent RNFL, macular thickness measurements, and ganglion cell analysis using Cirrus high-definition (HD) OCT. Patients with KC were classified according to the Amsler–Krumeich Classification. The measurements were analyzed in all quadrants for each KC stage ...

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    22. Optic Nerve Parameters in Obese Children as Measured by Spectral Domain Optical Coherence Tomography

      Optic Nerve Parameters in Obese Children as Measured by Spectral Domain Optical Coherence Tomography

      Purpose : To investigate whether an association exists between obesity and optic nerve parameters. Methods : This was a prospective comparative study including 125 eyes of 63 obese and 122 eyes of 62 healthy pediatric subjects. Optic nerve measurements were performed using the Cirrus spectral domain optical coherence tomograph (SD-OCT). Results : The disc area, cup volume, mean and vertical C/D ratio, inferior and temporal RNFL thickness values were significantly higher in the control group than the obese group; however, age, sex, mean, superior and nasal RNFL thickness and rim area measurements were not statistically significantly different between the two groups. Age ...

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