1. Articles in category: Ophthalmology

    553-576 of 5623 « 1 2 ... 21 22 23 24 25 26 27 ... 233 234 235 »
    1. SD-OCT based management of traumatic sub-macular hemorrhage-Our experience

      SD-OCT based management of traumatic sub-macular hemorrhage-Our experience

      Dear Editor, We read with interest the article on sub-macular hemorrhage by Rishi et al . [1] We congratulate the authors for bringing out this article as there is paucity of information especially, with regard to the management and prognosis. Authors have pointed out the histological location of the sub-macular hemorrhage on optical coherence tomography (OCT) being sub-retinal and sub- Retinal Pigment pithelium (RPE). They have also rightly inferred that sub-RPE bleed is not amenable to pneumatic displacement. However, we beg to differ on their comment that sub-RPE hemorrhage have poor prognosis irrespective of the etiology. We would like to share ...

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    2. Optical coherence tomographic findings in optic nerve hypoplasia

      Optical coherence tomographic findings in optic nerve hypoplasia

      We investigated a case of unilateral optic nerve hypoplasia using spectral domain optical coherence tomography (SDOCT). Optical coherence tomography was done on both eyes using 5-line Raster scan for the fovea to analyze the retinal nerve fiber layer thickness, inner retinal layer thickness, outer retinal layer thickness, and optic disc cube scan for the disc. Retinal nerve fiber layer thickness, inner retinal layer thickness, and outer retinal layer thickness were manually measured at 21-points of each five lines, and results were compared between both eyes. Retinal nerve fiber layer thickness and inner retinal layer thickness of optic nerve hypoplasia were ...

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    3. Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

      Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

      Purpose To characterize optic nerve head (ONH) morphology and parameters, including vertical disk diameter, vertical cup diameter, and vertical cup/disk ratio in healthy, full-term newborns using a handheld spectral domain optical coherence tomography (SD-OCT) device. Methods In this prospective observational case series, healthy white, black, and Hispanic full-term newborns delivered at the Duke Birthing Center between August 2010 and May 2011 underwent dilated fundus examination and SD-OCT imaging of the optic nerve in each eye. OCT parameters were calculated and compared for each group of infants. Results A total of 58 consecutive newborns of white (n = 22), black (n ...

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    4. Blood Vessel Patterns in Small Choroidal Tumors

      Blood Vessel Patterns in Small Choroidal Tumors

      The purpose of this study is to see if mapping blood vessel patterns with optical coherence tomography (OCT) will help identify life-threatening choroidal tumors in their early stages and improve overall patient survival through early detection. Uveal melanomas are melanocytic tumors that arise in the pigmented tissues of the eye: the iris, ciliary body, and choroid. Iris melanomas rarely metastasize (spread to other tissues or organs). In contrast, uveal melanomas arising in the ciliary body and choroid are highly malignant (cancerous and invasive to other tissues or organs). Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening ...

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    5. Vascular Response to Brachytherapy Using Functional OCT

      Vascular Response to Brachytherapy Using Functional OCT

      The purpose of this study is to learn how blood flows to tumors in patients treated with I-125 plaque brachytherapy for uveal melanoma. Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening cancer, and even eye-sparing therapy with radiation treatment often leads to significant loss of vision. Major challenges to providing care to patients with uveal melanoma include the inability to accurately predict long-term vision in an eye treated with radiation, due to a poor understanding of the nature of radiation retinopathy and optic neuropathy. Optical coherence tomography (OCT) is a commonly used ophthalmic imaging modality that ...

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    6. Comparison of three-dimensional optical coherence tomography and combining a rotating Scheimpflug camera with a Placido topography system for forme fruste keratoconus diagnosis

      Comparison of three-dimensional optical coherence tomography and combining a rotating Scheimpflug camera with a Placido topography system for forme fruste keratoconus diagnosis

      Objective To evaluate the ability of parameters measured by three-dimensional (3D) corneal and anterior segment optical coherence tomography (CAS-OCT) and a rotating Scheimpflug camera combined with a Placido topography system (Scheimpflug camera with topography) to discriminate between normal eyes and forme fruste keratoconus. Methods Forty-eight eyes of 48 patients with keratoconus, 25 eyes of 25 patients with forme fruste keratoconus and 128 eyes of 128 normal subjects were evaluated. Anterior and posterior keratometric parameters (steep K, flat K, average K), elevation, topographic parameters, regular and irregular astigmatism (spherical, asymmetry, regular and higher-order astigmatism) and five pachymetric parameters (minimum, minimum–median ...

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    7. Measurement of Normal Macular Thickness Using Cirrus Optical Coherence Tomography Instrument in Iranian Subjects with Normal Ocular Condition

      Measurement of Normal Macular Thickness Using Cirrus Optical Coherence Tomography Instrument in Iranian Subjects with Normal Ocular Condition

      Purpose: To describe the macular thickness map of Iranian adult with normal retinal status as measured by Cirrus’ optical coherence tomography (OCT) instrument Methods: In this cross-sectional study, one eye of subjects with normal ocular examination and retinal status of at least one eye were recruited. The 512×128-scan pattern and scan area of 6×6 mm2 with software version 4 protocol in Cirrus OCT apparatus were used for data acquisition and analysis. Results: A total of 98 individuals participated in this study. 45.9% of the participants (i.e., 45 subjects) were male. The mean age of the subjects ...

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    8. A Prospective, Comparative, Observational Study on Optical Coherence Tomography of the Anterior Eye Segment

      A Prospective, Comparative, Observational Study on Optical Coherence Tomography of the Anterior Eye Segment

      Background: We compared two commercially available spectral-domain optical coherence tomography (OCT) devices according to their capacity of imaging the anterior segment of the eye with the same detail and quality. Methods: A prospective, observational, single-visit study with individuals aged 18 years and older was conducted on two different OCT devices: the Spectralis™ OCT and the RTVue™ OCT. The resulting OCT images of both study devices of each study subject were compared and qualified by a single investigator according to the identification of corresponding structures and pathologies (primary endpoint) and the comparability of the clinical information given (secondary endpoint). Results: We ...

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    9. Topographic Optic Disc Changes After Successful Trabeculectomy Evaluated Using Spectral Domain Optical Coherence Tomography

      Topographic Optic Disc Changes After Successful Trabeculectomy Evaluated Using Spectral Domain Optical Coherence Tomography

      Purpose: To investigate topographic optic disc changes after surgical intraocular pressure (IOP) reduction in adults with open angle glaucoma (OAG). Methods: Optic discs of patients with advanced primary open angle or exfoliation glaucoma were imaged using optical coherence tomography within 1 week before trabeculectomy . Patients were rescanned 1 week, 1 month, and 1 year after surgery. Maximum cup depth (MCD), and average cup depth (ACD) were calculated. Results: Twenty-two eyes from 20 patients (age, 70.5±10.6 years; average mean defect of visual field, −15.0±9.8 dB) were followed up for 1 year. The IOP decreased from ...

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    10. Combination of optic disc rim area and retinal nerve fiber layer thickness for early glaucoma detection by using spectral domain OCT

      Combination of optic disc rim area and retinal nerve fiber layer thickness for early glaucoma detection by using spectral domain OCT

      BACKGROUND: To compare the diagnostic ability of optic disc rim area (RA), retinal nerve fiber layer thickness (RNFLT), and their combination on sector-based analysis of spectral domain optical coherence tomography (Cirrus OCT) in discriminating subjects with early-stage open angle glaucoma (OAG) from normal subjects. METHODS: RA and RNFLT of 78 early OAG and 80 normal subjects were measured on Cirrus OCT at the global area, 4 quadrants, 12 clock hours, and 7 + 11 o'clock (a sector that includes 7 and 11 o'clock). A new parameter, RR (a multiplication of the RA and RNFLT) was derived to identify the ...

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    11. The attenuation of retinal nerve fiber layer thickness and cognitive deterioration

      The attenuation of retinal nerve fiber layer thickness and cognitive deterioration

      Thinner retinal nerve fiber layer (RNFL) has been reported in Alzheimer's disease (AD) patient. However, whether changes in RNFL thickness can predict the cognitive deterioration remains unknown. We therefore set out a prospective clinical investigation to determine the potential association between the attenuation of RNFL thickness and the deterioration of cognitive function over a period of 25 months. We assessed cognitive function using the Repeatable Battery for the Assessment of Neuropsychological Status and measured RNFL thickness employing optical coherence tomography in 78 participants (mean age 72.31 ± 3.98 years, 52% men). The participants were categorized as stable participants ...

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    12. Ocular anterior segment biometry and high-order wavefront aberrations during accommodation

      Ocular anterior segment biometry and high-order wavefront aberrations during accommodation

      Purpose: To investigate the relationships between the ocular anterior segment biometry and the ocular high-order aberrations (HOAs) during accommodation by combined ultra-long scan depth optical coherence tomography (UL-OCT) and wavefront sensor. Methods: Thirty-five right eyes of young healthy subjects (21 women and 14 men; age: 25.6 ± 3.1 years; spherical equivalent refractive error: -0.41 ± 0.59 D) were enrolled. A custom-built UL-OCT and a wavefront sensor were combined. They were able to image the ocular anterior segment and to measure the HOAs during accommodation. The differences in the biometric dimensions and in the HOAs between the non-accommodative and ...

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    13. Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

      Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

      Purpose: To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT). Methods: RNFL thickness and optic disc parameters were obtained in 65 patients aged 50.1 ± 7.7 years. Percentage differences in all parameters were calculated and analyzed between groups. Results: The mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes ( P < 0.01). The greatest decrease in RNFL thickness was observed at the inferior (39.5%) and superior (39.3%) quadrants and at ...

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    14. MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation

      MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation

      Purpose: To describe the spectrum of pigment epithelial detachments (PEDs) occurring mainly in age-related macular degeneration and central serous chorioretinopathy and also in other inflammatory, neoplastic and iatrogenic, retinal, and systemic disorders. Methods: Pigment epithelial detachments are divided into drusenoid, serous, vascularized, or mixed categories. Results: The clinical presentation, classification, and natural history of PEDs are reviewed as illustrated with multimodal imaging combining traditional and novel imaging techniques, including fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and spectral domain optical coherence tomography. Most PEDs occur because of pathophysiologic mechanisms taking place below the retinal pigment epithelium that are difficult to ...

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      Mentions: K. Bailey Freund
    15. Optic Disc Drusen in a Child: Diagnosis Using Noninvasive Imaging Tools

      Optic Disc Drusen in a Child: Diagnosis Using Noninvasive Imaging Tools

      Purpose: To describe a case of bilateral optic nerve head drusen (ONHD) in a pediatric patient and the complementary use of advanced noninvasive imaging techniques to confirm this diagnosis. Case Report: A 15-year-old female adolescent with type 1 diabetes and no ocular history was seen at a routine screening without complaints. Visual acuity was 20/20 bilaterally, and visual fields using frequency doubling technology (Zeiss Humphrey Systems, Dublin, CA) were within normal limits. Fundus photography (CX-1 Mydriatic/Non-Mydriatic Hybrid Digital Retinal Camera, Canon, Toyko, Japan) showed slight elevation of the left disc margin, with lack of physiologic cup, elevation of ...

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    16. High resolution OCT quantitative analysis of the space between the IOL and the posterior capsule during the early cataract post-operative period

      High resolution OCT quantitative analysis of the space between the IOL and the posterior capsule during the early cataract post-operative period

      Purpose: To quantitatively characterize the space between the intraocular lens (IOL) and the posterior capsule (IOL-PC space) during the early post-phacoemulsification period, using high resolution optical coherence tomography (OCT). Methods: Thirty eyes of 30 patients who underwent phacoemulsification were recruited and randomly divided into two groups. Acrysof Natural IQ IOLs were implanted in one group (n = 15), and Adapt-AO IOLs were implanted into the other (n = 15). A custom built OCT instrument was used to image the IOL-PC space at 1 day, 1 week, and 1 month after surgery. Slit-lamp examination and auto refraction were performed at each visit. Results ...

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    17. Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography

      Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography

      Purpose. To analyze microstructural changes in the external limiting membrane (ELM) and photoreceptor layer before and after early and late conventional laser treatment in central serous chorioretinopathy (CSC) in 12 months follow-up study. Methods. A retrospective observational study included Group A: 19 patients (19 eyes) with symptomatic acute CSC and Group B: 16 patients (16 eyes) with symptomatic chronic CSC. Retinal microstructural changes were analyzed with SD-OCT paying a particular role in examining the photoreceptor layer and ELM. Results.The length of the photoreceptors, prior to treatment, was approximately 84

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    18. Imaging in retina units: changes observed during the last 12 years

      Imaging in retina units: changes observed during the last 12 years

      Purpose: The last decade has seen many improvements in the imaging of the choroids, retina, and vitreous. However, there are no available data about changes in the practice of imaging in retina units. The present study was therefore undertaken to document the 12-year changes in this practice in retina units in France, particularly the relative changes in the distribution of the different imaging methods. Methods: This retrospective study was performed in 4 different retina units considered to be representative of retina units in France. They comprise 2 departments of ophthalmology in university-based hospitals in Paris and Nantes, one in a ...

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    19. Choroidal changes by ocular coherence tomography in white dot syndrome

      Choroidal changes by ocular coherence tomography in white dot syndrome

      Purpose To evaluate the findings of optical coherence tomography (OCT) in the acute and convalescent stages in patients with white dot syndrome. Patients were followed up at our clinic for at least 6 months. Materials and methods A consecutive case series of patients with white dot syndrome were enrolled in this study. Only patients with disease onset less than 1 week were included in this study. Slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, indocyanine green angiography (ICGA), OCT, visual field test, and corrected decimal visual acuity test were performed on all patients. Results A total of eight eyes from eight patients ...

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    20. Characteristic Findings of Optical Coherence Tomography in Retinal Angiomatous Proliferation

      Characteristic Findings of Optical Coherence Tomography in Retinal Angiomatous Proliferation

      Purpose To identify the unique pathologic findings of retinal angiomatous proliferation (RAP) in optical coherence tomography (OCT). Methods Retrospectively, 29 eyes of 25 patients with age-related macular degeneration and complicated RAP were analyzed. All 29 eyes had choroidal neovascularization (CNV) in the area of pigment epithelial detachment (PED) or adjacent to it, which was visible with fluorescein angiography or indocyanine green angiography. Cross-sectional images were obtained by OCT scanning through the CNV lesions. Results Six distinctive findings of OCT included drusen (100%), inner retinal cyst (80%), outer retinal cyst (68%), fibrovascular PED (84%), serous retinal detachment (40%), and PED (68 ...

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    21. Preoperative and Postoperative Optical Coherence Tomography Findings in Patients with Rhegmatogenous Retinal Detachment Involving the Macular Region

      Preoperative and Postoperative Optical Coherence Tomography Findings in Patients with Rhegmatogenous Retinal Detachment Involving the Macular Region

      Purpose . To evaluate morphologic changes of the macula, we observed eyes with rhegmatogenous retinal detachment (RRD) involving the macular region by optical coherence tomography (OCT). Subjects and Methods . We studied 26 eyes with RRD before and after surgery, assessing visual acuity, the height of retinal detachment at the fovea (HRD), and morphologic changes of the macular region. The interval between the onset and surgery was also determined. We examined the external limiting membrane (ELM) after surgery and the continuity of the inner segment-outer segment junction (IS/OS junction) of the photoreceptor layer. Results . Impairment of visual acuity was observed when ...

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    22. Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT

      Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT

      Custom high-resolution high-speed anterior segment spectral domain Optical Coherence Tomography (OCT) provided with automatic quantification and distortion correction algorithms was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo in four subjects, for accommodative demands between 0 to 6 D in 1 D steps. Anterior and posterior lens radii of curvature decreased with accommodative demand at rates of 0.73 and 0.20 mm/D, resulting in an increase of the estimated optical power of the eye of 0.62 D per diopter of accommodative demand. Dynamic fluctuations in crystalline lens radii of curvature, anterior chamber depth and ...

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    23. Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Baseline Retinal Nerve Fiber Layer Thickness and Macular Volume Quantified by OCT in the North American Phase 3 Fingolimod Trial for Relapsing-Remitting Multiple Sclerosis

      Background: Patients with multiple sclerosis (MS) demonstrate thinning of peripapillary retinal nerve fiber layer (RNFL) and decreased macular volume as measured by optical coherence tomography (OCT). To our knowledge, there are no previous reports from a large MS OCT database with strict quality control measures that quantitate RNFL and macula in patients with relapsing-remitting multiple sclerosis. Methods: The University of California Davis OCT Reading Center gathered OCT data at baseline as part of the North American phase 3 trial of fingolimod (Gilenya). Average RNFL thickness (RNFLT) and macular volume (TMV) were measured using time domain OCT (TD-OCT). RNFL quadrants, clock ...

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