1. Articles in category: Ophthalmology

    553-576 of 5902 « 1 2 ... 21 22 23 24 25 26 27 ... 244 245 246 »
    1. Analysis of short-term change in subfoveal choroidal thickness in eyes with age-related macular degeneration using optical coherence tomography

      Analysis of short-term change in subfoveal choroidal thickness in eyes with age-related macular degeneration using optical coherence tomography

      BACKGROUND AND OBJECTIVE: To measure the subfoveal choroidal thickness in patients with age-related macular degeneration (AMD) over 6 months. PATIENTS AND METHODS: A retrospective, observational study of patients with AMD followed up for 6 months at the New England Eye Center. Baseline and 6-month follow-up subfoveal choroidal thickness was measured using spectral-domain OCT and compared. RESULTS: For the entire cohort, there was statistically significant thinning of the subfoveal choroidal thickness at 6 months compared to baseline that was driven by the cohort of patients with neovascular AMD (181.2 ± 75 μm to 173.4 ± 63 μm; P = .049). CONCLUSION: There ...

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    2. Alterations in the Neural and Connective Tissue Components of Glaucomatous Cupping after Glaucoma Surgery using Swept Source Optical Coherence Tomography

      Alterations in the Neural and Connective Tissue Components of Glaucomatous Cupping after Glaucoma Surgery using Swept Source Optical Coherence Tomography

      Purpose: To visualize changes in deep optic nerve head (ONH) structures following glaucoma surgery using (3-dimensional (3D)) swept-source optical coherence tomography (SS-OCT) and to determine the clinical and structural factors associated with postoperative lamina cribrosa (LC) and prelaminar neural tissue (PLT) changes. Methods: In this prospective observational case series, SS-OCT thin-sliced datasets of the ONH covering a 3×3-mm area comprised of 256 B-scans (interval between scans = ∼12µm) were obtained before and 3 months after the surgery and evaluated in 73 eyes of 73 patients with glaucoma. Bruch's membrane opening (BMO) and anterior LC boundary were manually delineated ...

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    3. Choroidal observations in posterior scleritis using high-penetration optical coherence tomography

      Choroidal observations in posterior scleritis using high-penetration optical coherence tomography

      To investigate the choroidal morphologic changes in two patients with posterior scleritis. We used high-penetration optical coherence tomography (HP-OCT) in vivo with a long-wavelength light source (1,060 nm) to view the choroidal changes. In patient 1 with unilateral scleritis, the subfoveal choroidal thickness of the right eye was 418 μm with a serous retinal detachment (SRD) at the initial visit. The treatment regimen was prednisolone 30 mg/day, and the posterior scleritis resolved. Follow-up HP-OCT showed the following choroidal thicknesses—266 μm on day 27 with no SRD, 245 μm on day 69, and 200 μm on day 216 ...

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    4. Intensity-interferometric spectral-domain optical coherence tomography with dispersion cancellation

      Intensity-interferometric spectral-domain optical coherence tomography with dispersion cancellation

      We describe a technique for cancelling group-velocity dispersion in spectral-domain (SD) optical coherence tomography (OCT) based on classical intensity correlations. As a classical analogue of quantum OCT, a Hong–Ou–Mandel interferometer is combined with a conventional SD-OCT setup, and correlations between different spectral intensities are calculated. It is shown theoretically that a simple computational procedure used in SD-OCT enables scanless cross-sectional imaging with both dispersion cancellation and a factor-of- 2 √ resolution enhancement. The method involves no ultrafast detectors and works with common light sources.

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    5. Adaptive optics SLO/OCT for 3D imaging of human photoreceptors in vivo

      Adaptive optics SLO/OCT for 3D imaging of human photoreceptors in vivo

      We present a new instrument that is capable of imaging human photoreceptors in three dimensions. To achieve high lateral resolution, the system incorporates an adaptive optics system. The high axial resolution is achieved through the implementation of optical coherence tomography (OCT). The instrument records simultaneously both, scanning laser ophthalmoscope (SLO) and OCT en-face images, with a pixel to pixel correspondence. The information provided by the SLO is used to correct for transverse eye motion in post-processing. In order to correct for axial eye motion, the instrument is equipped with a high speed axial eye tracker. In vivo images of foveal ...

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    6. Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Received a 2014 NIH Grant for $886,367 for Intraoperative OCT guidance of Intraocular Surgery. The principal investigator is Joe Izatt, The program begin in 2013 and ends in 2016. Below is a summary of the proposed work. This Bioengineering Research Partnership proposal brings together a team of experts in ophthalmic imaging and surgery to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon's current stereo microscopic view of ocular structures by bringing optical coherence tomography (OCT) technology, which is already well accepted in ophthalmic practice, into the ...

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    7. Quantitative Analysis of Diabetic Macular Ischemia using Optical Coherence Tomography

      Quantitative Analysis of Diabetic Macular Ischemia using Optical Coherence Tomography

      Purpose: To describe the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). Methods: Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteria defined by the Early Treatment Diabetic Retinopathy Study. Quantitative analysis of foveal avascular zone (FAZ), and OCT images were performed using custom software. Results: In all eyes, the outer retina was thicker in eyes with DMI, (167.4 ± 18.5 µm) versus (150.4 ± 31.4 µm) (p=0.04). However, sub analysis of ...

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    8. The Prevalence of Retinal and Optical Coherence Tomography Findings in Preeclamptic Women

      The Prevalence of Retinal and Optical Coherence Tomography Findings in Preeclamptic Women

      Purpose: To evaluate retinal and optical coherence tomography findings and establish their prevalence in preeclamptic women. Methods: Twenty-seven preeclamptic women who underwent clinical examinations with both slit-lamp biomicroscopy and optical coherence tomography were prospectively studied. Results: Three of the 4 women (14.8%) identified by clinical examinations as having retinal findings related to preeclampsia had visual disturbances. Optical coherence tomography revealed retinal pathology in 2 women (7.4%) consisting of retinal edema, subretinal fluid, photoreceptors irregularities, and lesions at the retinal pigment epithelium level (Elschnig spots). The mean retinal nerve fiber layer thickness was significantly higher in women with pathologic ...

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    9. Characterization of retinal nerve fiber layer thickness changes associated with Leber's hereditary optic neuropathy by optical coherence tomography

      Characterization of retinal nerve fiber layer thickness changes associated with Leber's hereditary optic neuropathy by optical coherence tomography

      In the present study, the changes in the retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and the correlation between the RNFL thickness and the best corrected visual acuity (BCVA) was evaluated. A cross-sectional study was performed. Sixty‑eight eyes from patients with LHON and 30 eyes from healthy individuals were scanned. Affected eyes were divided into 5 groups according to disease duration: Group 1, ≤3 months; group 2, 4‑6 months; group 3, 7‑9 months; group 4, 10‑12 months; and group 5 ...

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    10. Integrated optical coherence tomography and reflectometry system for ocular anterior segment imaging and tear film thickness evaluation

      Integrated optical coherence tomography and reflectometry system for ocular anterior segment imaging and tear film thickness evaluation

      We report an integrated optical coherence tomography (OCT) and reflectometry system for ophthalmology imaging. The dual-functional device provides a complementary high-resolution tear film evaluation by reflectometry and anterior segment imaging by OCT, offering a more comprehensive anterior segment examination. The imaging measurement capabilities have been demonstrated on a human eye as well as on a model eye. The minimum measured tear film thickness is 0.3 μ m with measurement resolution of less than ± 0.58 % of film thickness yet the OCT anterior segment offers a depth resolution of 7 μ m with a 45-nm bandwidth superluminescent light source at 840-nm center ...

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    11. Degradation in the degree of polarization in human retinal nerve fiber layer

      Degradation in the degree of polarization in human retinal nerve fiber layer

      Using a fiber-based swept-source (SS) polarization-sensitive optical coherence tomography (PS-OCT) system, we investigate the degree of polarization (DOP) of light backscattered from the retinal nerve fiber layer (RNFL) in normal human subjects. Algorithms for processing data were developed to analyze the deviation in phase retardation and intensity of backscattered light in directions parallel and perpendicular to the nerve fiber axis (fast and slow axes of RNFL). Considering superior, inferior, and nasal quadrants, we observe the strongest degradation in the DOP with increasing RNFL depth in the temporal quadrant. Retinal ganglion cell axons in normal human subjects are known to have ...

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    12. Imaging of the optic nerve and retinal nerve fiber layer: An essential part of glaucoma diagnosis and monitoring

      Imaging of the optic nerve and retinal nerve fiber layer: An essential part of glaucoma diagnosis and monitoring

      Because glaucomatous damage is irreversible early detection of structural changes in the optic nerve head and retinal nerve fiber layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic nerve head, retinal nerve fiber layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive ...

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    13. Importance of 3-D image reconstruction of spectral-domain OCT on outcome of grid laser photocoagulation for diffuse diabetic macular edema

      Importance of 3-D image reconstruction of spectral-domain OCT on outcome of grid laser photocoagulation for diffuse diabetic macular edema

      AIM: To present the outcome of modified grid laser photocoagulation (GLP) in diffuse diabetic macular edema (DDME) in eyes without extrafoveal and/or vitreofoveal traction. METHODS: Inclusion criteria for the retrospective study were DDME eyes of patients with type II diabetes mellitus that had ≥4 months of follow-up following GLP. Only one eye per patient was analyzed. Using 3-D spectral-domain optical coherence tomography (3-D SD-OCT), eyes that had either extrafoveal or vitreofoveal traction, or had been previously treated by an intravitreal medication(s) were excluded. Treated DDME eyes were divided into 4 groups:A) “Classic” DDME that involved the central ...

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    14. Spectral-domain optical coherence tomography evaluation of vitreoretinal adhesions in idiopathic epiretinal membranes

      Spectral-domain optical coherence tomography evaluation of vitreoretinal adhesions in idiopathic epiretinal membranes

      Background Vitreoretinal adhesions play a key role in the vector forces exerted on the vitreoretinal interface, leading to tractional retina deformation and macular hole formation. The aim of this study was to identify the presence of vitreopapillary and vitreofoveal adhesions in idiopathic epiretinal membranes (ERMs) with spectral-domain optical coherence tomography (SD-OCT) and to evaluate their influence on the vitreoretinal interface. Methods Sixty-five eyes (65 patients) with idiopathic ERM and 64 healthy eyes (64 patients) underwent SD-OCT analysis. We studied vitreopapillary and vitreofoveal adhesion prevalence in eyes with idiopathic ERM using different SD-OCT patterns (“adherent” or “tractional”). We analyzed their influence ...

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    15. Anterior segment OCT imaging in mucopolysaccharidosestype I, II, and VI

      Anterior segment OCT imaging in mucopolysaccharidosestype I, II, and VI

      Purpose To describe the anterior segment optical coherence tomography (AS-OCT) characteristics of patients with ocular manifestations of mucopolysaccharidoses type I (Hurler), II (Hunter), and VI (Maroteaux–Lamy). Methods Prospective, observational study of nine consecutive patients with variants of mucopolysaccharidosis (MPS) attending the Paediatric Ophthalmology service at Manchester Royal Eye Hospital, UK. All patients underwent Visante AS-OCT imaging as part of their ophthalmic assessment. Results Ocular involvement tended to be symmetrical. Angle-to-angle distance was significantly lower in MPS VI than in MPS I (P = 0.04). Anterior chamber depth, angle opening distance, trabecular-iris space area, and scleral spur angle tended to ...

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    16. Monthly OCT monitoring of Ozurdex for macular oedema related to retinal vascular diseases: re-treatment strategy (OCTOME Report 1)

      Monthly OCT monitoring of Ozurdex for macular oedema related to retinal vascular diseases: re-treatment strategy (OCTOME Report 1)

      Purpose To evaluate the morphological and functional changes following intravitreal Ozurdex (dexamethasone implant) injections in patients with macular oedema (MO) secondary to retinal vascular diseases. Design This is a single centre, exploratory phase III, prospective, open-label clinical study. Methods Thirty patients with MO secondary to retinal vascular disorders underwent assessments for best corrected visual acuity, contrast sensitivity, microperimetry, chromatic sensitivity, macular thickness, and morphology using spectral domain optical coherence tomography (SD-OCT) and fluorescein angiography at baseline. They were treated with intravitreal Ozurdex at baseline and monitored monthly with visual acuity and SD-OCT assessments up to 36 weeks. Re-treatment was permitted ...

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    17. Interocular symmetry in retinal and optic nerve parameters in children as measured by spectral domain optical coherence tomography

      Interocular symmetry in retinal and optic nerve parameters in children as measured by spectral domain optical coherence tomography

      Background/aims To report interocular differences in retinal nerve fibre layer (RNFL), optic nerve head and macular parameters in children using spectral domain optical coherence tomography (SD-OCT). Methods This was an observational cross-sectional study including 108 healthy children aged 6–17 years with no ocular abnormality except refractive error. After a comprehensive eye exam and axial length measurement, RNFL, optic nerve and macular thickness measurements were performed using the Cirrus OCT machine. Right and left eyes were compared and interocular differences were computed. Subjects were also divided into two groups based on age (under or over 10 years of age ...

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    18. Diagnostic Performance of Optical Coherence Tomography Ganglion Cell–Inner Plexiform Layer Thickness Measurements in Early Glaucoma

      Diagnostic Performance of Optical Coherence Tomography Ganglion Cell–Inner Plexiform Layer Thickness Measurements in Early Glaucoma

      Purpose To evaluate the glaucoma diagnostic performance of ganglion cell inner–plexiform layer (GCIPL) parameters used individually and in combination with retinal nerve fiber layer (RNFL) or optic nerve head (ONH) parameters measured with Cirrus HD-OCT (Carl Zeiss Meditec, Inc, Dublin, CA). Design Prospective cross-sectional study. Participants Fifty patients with early perimetric glaucoma and 49 age-matched healthy subjects. Methods Three peripapillary RNFL and 3 macular GCIPL scans were obtained in 1 eye of each participant. A patient was considered glaucomatous if at least 2 of the 3 RNFL or GCIPL scans had the average or at least 1 sector measurement ...

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    19. Correlation between retinal vessel density profile and circumpapillary RNFL thickness measured with Fourier-domain optical coherence tomography

      Correlation between retinal vessel density profile and circumpapillary RNFL thickness measured with Fourier-domain optical coherence tomography

      Aim To assess circumpapillary retinal vessel density (RVD) profiles and correlate them with retinal nerve fibre layer (RNFL) thickness measured by Fourier domain optical coherence tomography (FD-OCT). Methods RNFL thickness of 106 healthy volunteers was measured using Cirrus FD-OCT. A proprietary software was developed in MATLAB to assess the thickness and position of circumpapillary retinal vessels using the scanning laser ophthalmoscopy fundus image, centred on the optic disc. The individual retinal vessel positions and thickness values were integrated in a 256-sector RVD profile, and intrasubject and intersubject correlations were calculated. Results The mean value±SD for intrasubject correlation between RVD ...

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    20. Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial

      Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial

      Purpose: To determine the impact of segmentation error correction and precision of standardized grading of time domain optical coherence tomography (OCT) scans obtained during an interventional study for macular edema secondary to central retinal vein occlusion (CRVO). Methods: A reading center team of two readers and a senior reader evaluated 1199 OCT scans. Manual segmentation error correction (SEC) was performed. The frequency of SEC, resulting change in central retinal thickness after SEC, and reproducibility of SEC were quantified. Optical coherence tomography characteristics associated with the need for SECs were determined. Reading center teams graded all scans, and the reproducibility of ...

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      Mentions: Duke University
    21. Optical Coherence Tomography Predicts Visual Outcome in Acute Central Retinal Vein Occlusion

      Optical Coherence Tomography Predicts Visual Outcome in Acute Central Retinal Vein Occlusion

      Purpose: To investigate the clinical features of central retinal vein occlusion (CRVO) in relation to the presence of a prominent middle limiting membrane (p-MLM) sign on presenting optical coherence tomography, which may suggest macular ischemia and poor visual outcome. Methods: Fifty consecutive eyes with acute CRVO of <1 month of symptom duration before presentation were retrospectively reviewed. A hyperreflective line located in the outer plexiform layer (p-MLM) in optical coherence tomography was used as a sign of acute ischemia. Cases with p-MLM were grouped and compared with the group of eyes with no p-MLM sign (non-MLM group) for clinical features ...

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    22. Perspectives of an innovative ophthalmological technology: Optical coherence tomography (OCT) – What should be of interest to the neurologist?

      Perspectives of an innovative ophthalmological technology: Optical coherence tomography (OCT) – What should be of interest to the neurologist?

      Ocular coherence tomography has revolutionised the prospects of measuring the loss of retinal ganglion cells secondary to degenerative diseases and monitoring time-dependent changes of optic disc morphology, since the resolution has been improved considerably and the time required has been reduced. Although the non-invasive technique promises a high inter-session reproducibility, the limitations of retinal imaging and the problems of segmenting of the retinal layers have to be taken into account. While the first studies were limited to single sessions in small groups, further trials will elucidate how the retinal nerve fibre layer (RNFL) is altered in the course of different ...

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    23. Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema

      Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema

      Background: The pathogenesis of development and progression of neurosensory retinal detachment (NSD) in diabetic macular edema (DME) is not yet fully understood. The purpose of this study is to describe the spectral domain optical coherence tomography (SD-OCT) morphological characteristics of NSD associated with DME in the form of outer retinal communications and to assess the correlation between the size of communications and various factors. Materials and Methods: This was an observational retrospective nonconsecutive case series in a tertiary care eye institute. We imaged NSD and outer retinal communications in 17 eyes of 16 patients having NSD associated with DME using ...

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    24. Spectral-domain optical coherence tomography findings in chronic solar retinopathy

      Spectral-domain optical coherence tomography findings in chronic solar retinopathy

      Solar retinopathy is a clinical entity caused by any form of sun gazing most commonly attributed to solar eclipse viewing. [1] Other common causes include sunbathing, religious ritual, involving sun gazing, psychiatric illness, and military activities. [1] Solar retinopathy causes central visual distortion/loss. Acute cases present with typical history of sun exposure and easy to diagnose, but chronic cases are of challenge. Spectral-domain optical coherence tomography (SD-OCT) is a great tool to provide details comparable to histological changes. Here, we are discussing a patient with solar retinopathy diagnosed with the help of SD-OCT.

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