1. Articles in category: Ophthalmology

    553-576 of 8826 « 1 2 ... 21 22 23 24 25 26 27 ... 366 367 368 »
    1. Phenotypic characterization of X-linked retinoschisis: Clinical, electroretinography, and optical coherence tomography variables

      Phenotypic characterization of X-linked retinoschisis: Clinical, electroretinography, and optical coherence tomography variables

      Aims: To study the phenotypic characteristics of X-linked retinoschisis (XLRS) and report the clinical, electroretinogram (ERG), and optical coherence tomography (OCT) variables in Indian eyes. Design: A retrospective study. Materials and Methods: Medical records of 21 patients with retinoschisis who were genetically confirmed to have RS1 mutation were reviewed. The phenotype characterization included the age of onset, best-corrected visual acuity, refractive error, fundus findings, OCT, and ERG. Statistical Analysis Used: Data from both the eyes were used for analysis. A P < 0.05 was set as statistical significance. Data were not normally distributed ( P < 0.05, Shapiro wilk); hence, nonparametric ...

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    2. Intraoperative optical coherence tomography guided removal of premacular hemorrhage in Valsalva retinopathy

      Intraoperative optical coherence tomography guided removal of premacular hemorrhage in Valsalva retinopathy

      A 32-year-old male presented with 4 weeks history of sudden decrease of vision in his right eye following a bout of cough. The left eye was normal. The anterior segment in the right eye was normal. A dilated fundus of the right eye showed a 6 mm × 4 mm area of premacular hemorrhage [Figure 1] a. Spectral domain optical coherence tomography (SD-OCT) showed smooth convex dome-shaped hyper-reflectivity from blood with shadowing underneath [Figure 1] b. After informed consent, the patient underwent 25-gauge pars plana vitrectomy with removal of premacular blood. The premacular blood remained unchanged after triamcinolone-assisted posterior vitreous detachment ...

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    3. Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects

      Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects

      Purpose To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. Design Cross-sectional, case-control study. Participants A total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage. Methods Optical coherence tomography (OCT) angiography–derived circumpapillary vessel density (cpVD) was calculated as the percentage area occupied by vessels in the measured region extracted from the retinal nerve fiber layer ...

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    4. High-resolution, dual-depth spectral-domain optical coherence tomography with interlaced detection for whole-eye imaging

      High-resolution, dual-depth spectral-domain optical coherence tomography with interlaced detection for whole-eye imaging

      Dual-depth spectral-domain optical coherence tomography (SD-OCT) enables high-resolution in vivo whole-eye imaging. Two orthogonally polarized beams from a source are focused simultaneously on two axial positions of the anterior segment and the retina. For the detector arm, a 1 × 2 ultrafast optical switch sequentially delivers two spectral interference signals to a single spectrometer, which extends the in-air axial depth range up to 9.44 mm. An off-pivot complex conjugate removal technique doubles the depth range for all anterior segment imaging. The graphics-processing-unit-based parallel signal processing algorithm supports fast two- and three-dimensional image displays. The obtained high-resolution anterior and retinal images ...

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    5. OCT-guided PCI associated with better outcomes than standard PCI

      OCT-guided PCI associated with better outcomes than standard PCI

      PCI guided by optical coherence tomography was linked with better clinical outcomes vs. standard angiography-guided PCI, according to results of the DOCTORS study presented at the European Society of Cardiology Congress. In patients with non-ST-segment elevation ACS, OCT “provided useful additional information beyond that obtained by angiography alone, and impacted directly on physician decision-making,” presenter Nicolas Meneveau, MD , PhD , from University Hospital Jean Minjoz, Besançon, France, said in a press release. The researchers analyzed data from 240 patients with NSTEACS who were randomly assigned to undergo PCI guided by standard fluoroscopy alone or fluoroscopy plus OCT. The primary endpoint ...

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    6. Quantitative Analysis of Lens Nuclear Density Using Optical Coherence Tomography (OCT) with a Liquid Optics Interface: Correlation between OCT Images and LOCS III Grading

      Quantitative Analysis of Lens Nuclear Density Using Optical Coherence Tomography (OCT) with a Liquid Optics Interface: Correlation between OCT Images and LOCS III Grading

      urpose . To quantify whole lens and nuclear lens densities using anterior-segment optical coherence tomography (OCT) with a liquid optics interface and evaluate their correlation with Lens Opacities Classification System III (LOCS III) lens grading and corrected distance visual acuity (BCVA). Methods . OCT images of the whole lens and lens nucleus of eyes with age-related nuclear cataract were analyzed using ImageJ software. The lens grade and nuclear density were represented in pixel intensity units (PIU) and correlations between PIU, BCVA, and LOCS III were assessed. Results . Forty-seven eyes were analyzed. The mean whole lens and lens nuclear densities were 26.99 ...

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    7. Directional optical coherence tomography systems and methods

      Directional optical coherence tomography systems and methods

      An optical coherence tomography system that includes an optical device having an adjustable optical element configured to displace a pupil entry point of light is provided. Optical coherence tomography methods using the optical coherence tomography system are also provided. The subject optical coherence tomography systems and methods find use in a variety of different applications, including imaging applications.

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    8. Regional comparisons of optical coherence tomography angiography vessel density in primary open angle glaucoma

      Regional comparisons of optical coherence tomography angiography vessel density in primary open angle glaucoma

      Purpose To compare the diagnostic abilities of the vessel densities in optic nerve head (ONH), peripapillary and macular regions measured using optical coherence tomography angiography (OCTA) in eyes with primary open angle glaucoma (POAG), and to evaluate the effect of glaucoma severity (based on the mean deviation, MD), optic disc size and pre-treatment intraocular pressure (IOP). Design Cross-sectional study Methods Seventy-eight eyes of 53 control subjects and 64 eyes of 39 POAG patients underwent OCTA imaging. Area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities of vessel densities in ONH, peripapillary and macular regions were analyzed ...

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    9. The Benefits and Pitfalls of OCT Angiography by Professor Giovanni Staurenghi

      The Benefits and Pitfalls of OCT Angiography by Professor Giovanni Staurenghi

      Professor Giovanni Staurenghi, University of Milan, discusses the unique attributes of hybrid angiography at the Heidelberg Engineering 5th Annual Masterclass in May 2016. The presentation includes a thoughtful and rational look at the role of OCT angiography* in the clinical decision making process as part of a multimodality imaging approach to patient investigation and diagnosis.

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    10. Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance

      Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance

      Purpose: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer. Patients and methods: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography. All study participants after initial training underwent MPOD measurement twice in both eyes in a randomized sequence. The repeatability was tested using Altman and Bland ...

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    11. Free-Floating Pigmented Vitreous Cyst: Optical Coherence Tomography Findings

      Free-Floating Pigmented Vitreous Cyst: Optical Coherence Tomography Findings

      A 54-year-old woman presented with a chronic floater in the right eye. Dilated fundus examination revealed a pigmented free-floating vitreous cyst (Fig 1 A , Optos, Marlborough, MA). Saccades caused quick and fluid movements of the mobile sphere. Spectral-domain optical coherence tomography (SD OCT) (Fig 1 B , Spectralis; Heidelberg, Heidelberg, Germany) demonstrated a round, hyperreflective shell with hyporeflective contents. The lesion is anterior to the upper limit of the OCT and appears as a reflected image with shadowing of the underlying retina.

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    12. Anterior segment optical coherence tomography of silicone oil keratopathy

      Anterior segment optical coherence tomography of silicone oil keratopathy

      A 77-year-old woman underwent pars plana vitrectomy for recurrent retinal detachment with silicone oil injection 10 years before presentation. Also the patient was placed on antiglaucoma medications. The patient had a history of recurrent corneal ulcerations in both eyes due to severe dry eyes. Examination revealed no light perception with a disfiguring central opaque corneal bulge in the left eye (figure 1). Anterior segment optical coherence tomography (OCT) revealed a marked thickening …

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    13. Retinal and choroidal thicknesses measured with swept-source optical coherence tomography after surgery for idiopathic macular hole

      Retinal and choroidal thicknesses measured with swept-source optical coherence tomography after surgery for idiopathic macular hole

      To evaluate the changes in retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), retinal thickness (RT), and subfoveal choroidal thickness (SFCT) in eyes that received pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for idiopathic macular hole (IMH) and to compare these data with data from fellow eyes and healthy controls. This cross-sectional study included 49 subjects. Eighteen eyes that underwent surgery for IMH, 18 fellow eyes, and 31 eyes of the healthy controls were designated as group 1, group 2, and group 3, respectively. The RNFLT, GCLT, RT, and SFCT were measured by using ...

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    14. A Case of Wyburn-Mason Syndrome with Facial Nevus Flammeus and the Associated Optical Coherence Tomography Findings

      A Case of Wyburn-Mason Syndrome with Facial Nevus Flammeus and the Associated Optical Coherence Tomography Findings

      Purpose To describe a case of Wyburn-Mason Syndrome, which is a rare phakomatosis, and its associated optical coherence tomography findings. Case summary A 5-year-old boy was referred to our clinic for decreased vision in his right eye. He had nevus flammeus on his right forehead, upper eyelid, and cheek. His best corrected visual acuity was hand motion in the right eye, in which a relative afferent pupillary defect was noted. Fundus examination of the right eye showed marked dilation and tortuosity of retinal vessels, which could not be discriminated between arteries and veins on the posterior pole. Optical coherence tomography ...

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    15. Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Purpose : Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. Methods : In the present study, OCT-A based on a Heidelberg Engineering Spectralis system was used to investigate the vascular network in mice. Data was compared with FA and confocal microscopy of flat-mount histology stained with isolectin IB4. For quantitative analysis the National Cancer Institute's AngioTool software was used. Vessel density, the number of vessel junctions, and endpoints were measured and compared between the imaging ...

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    16. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL MICROVASCULATURE IN GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL MICROVASCULATURE IN GEOGRAPHIC ATROPHY

      Purpose: To examine the retinal and choroidal foveal and parafoveal vasculature in patients with bilateral geographic atrophy (GA) secondary to age-related macular degeneration using optical coherence tomography angiography (OCTA). Methods: Fourteen eyes from 7 patients with and without fovea-sparing bilateral GA at St. Erik Eye Hospital. All patients were examined by optical coherence tomography angiography, en face OCT and fundus autofluorescence (FAF). Segmented optical coherence tomography angiography flow scans were obtained from the superficial retinal vascular layer (SL) and the choriocapillaris (CC) and correlated with areas of retinal pigment epithelial (RPE) loss on fundus autofluorescence. The foveal avascular zone (FAZ ...

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    17. Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography

      Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography

      Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. We introduce a surgical imaging system employing four-dimensional (live volumetric imaging through time) microscope-integrated optical coherence tomography (4D MIOCT) capable of imaging at up to 10 volumes per second to visualize human microsurgery. A custom stereoscopic heads-up display provides real-time interactive volumetric feedback to the surgeon. We report that 4D MIOCT enhanced suturing accuracy and control of instrument positioning in mock surgical trials involving 17 ophthalmic surgeons ...

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    18. CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGHLY MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGHLY MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To visualize choroidal blood flow in larger vessels in highly myopic eyes using a phenomenon of the projection artifact to in the sclera using optical coherence tomography angiography. Methods: The retrospective study included 92 eyes (54 patients) with greater than 8 diopters of myopia. All eyes were examined using optical coherence tomography angiography (RTVue XR Avanti; Optovue Inc, Fremont, CA). The blood flow in choroidal vessels was evaluated by attempting to directly segment the choroid and also by placing the segmentation layer behind the choroid, within the sclera. Subfoveal choroidal thickness was also measured at the same time. The ...

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    19. CLINICALLY INVISIBLE RETINAL HEMANGIOBLASTOMAS DETECTED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FLUORESCEIN ANGIOGRAPHY IN TWINS

      CLINICALLY INVISIBLE RETINAL HEMANGIOBLASTOMAS DETECTED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FLUORESCEIN ANGIOGRAPHY IN TWINS

      Purpose: To report subclinical retinal hemangioblastoma detected by enhanced depth imaging optical coherence tomography and fluorescein angiography in at-risk twins. Methods: Case report. Results: A set of twins, age 7 years, (Twin A and Twin B) with known family history of von Hippel-Lindau disease (gene test positive) and no systemic manifestations were evaluated. Visual acuity was 20/20 in both eyes of both twins. Anterior segment examination and intraocular pressures were unremarkable in both eyes. Twin A showed no clinically visible tumor in the right eye, and a clinically evident 4-mm hemangioblastoma in the superior retina of the left eye ...

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    20. Optical Coherence Tomography Angiography of Retinal Perfusion in Chiasmal Compression

      Optical Coherence Tomography Angiography of Retinal Perfusion in Chiasmal Compression

      BACKGROUND AND OBJECTIVE: To evaluate the retinal perfusion in patients with chiasmal compression using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Retinal perfusion was evaluated using OCT angiograms in eight eyes of four patients with visual field (VF) defects due to chiasmal compression treated by tumor resection. The retinal perfusion in the area corresponding to the quadrants of the VF defects was investigated in each image. The vessel density was defined as the percentage area occupied by the vessels in the image. RESULTS: The decreased peripapillary retinal perfusion correlated with the quadrants of the VF defects on OCT angiograms ...

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    21. En Face Imaging of Epiretinal Membranes and the Retinal Nerve Fiber Layer Using Swept-Source Optical Coherence Tomography

      En Face Imaging of Epiretinal Membranes and the Retinal Nerve Fiber Layer Using Swept-Source Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE: To describe en face swept-source optical coherence tomography (SS-OCT) imaging of epiretinal membranes (ERMs) and the underlying retinal nerve fiber layer (RNFL). PATIENTS AND METHODS: SS-OCT images were captured in nine eyes with ERMs. These SS-OCT en face images were qualitatively compared to spectral-domain OCT (SD-OCT) en face images. Using SS-OCT, en face images of the RNFL were obtained, if possible. RESULTS: En face SS-OCT images of ERMs were obtained in all nine eyes of eight individuals with clinically diagnosed ERMs that were superior to SD-OCT images. Clear en face images of the RNFL were acquired in ...

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    22. En Face Spectral-Domain Optical Coherence Tomography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

      En Face Spectral-Domain Optical Coherence Tomography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

      BACKGROUND AND OBJECTIVE: To evaluate the diagnostic capability of en face spectral-domain optical coherence tomography (SD-OCT) in patients with polypoidal choroidal vasculopathy (PCV) diagnosed by indocyanine green angiography (ICGA). PATIENTS AND METHODS: A retrospective, consecutive case series of 100 eyes diagnosed with PCV by ICGA were imaged with en face SD-OCT. Evaluation of the PCV complex on en face SD-OCT was performed on the ability to diagnose PCV by the characteristic configuration of the PCV complex and the extent and size of the PCV lesion. RESULTS: The PCV complex was better visualized on ICGA in 45 eyes, on en face ...

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