1. Articles in category: Ophthalmology

    25-48 of 13767 « 1 2 3 4 5 ... 572 573 574 »
    1. AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      Angle closure glaucoma (ACG) is a more aggressive disease than open-angle glaucoma, where the abnormal anatomical structures of the anterior chamber angle (ACA) may cause an elevated intraocular pressure and gradually lead to glaucomatous optic neuropathy and eventually to visual impairment and blindness. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging provides a fast and contactless way to discriminate angle closure from open angle. Although many medical image analysis algorithms have been developed for glaucoma diagnosis, only a few studies have focused on AS-OCT imaging. In particular, there is no public AS-OCT dataset available for evaluating the existing methods in a ...

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    2. Optical Coherence Tomography Detects Retinal Changes in Hereditary Cerebral Amyloid Angiopathy

      Optical Coherence Tomography Detects Retinal Changes in Hereditary Cerebral Amyloid Angiopathy

      Background Investigating mutation carriers with Dutch‐type hereditary Cerebral Amyloid Angiopathy (D‐CAA), offers the possibility to identify markers in pre‐ and symptomatic stages of CAA. Optical Coherence Tomography (OCT) has shown potential to detect retinal changes in several neurodegenerative diseases. We performed an exploratory study on the thickness of retinal layers as possible (early) biomarker in D‐CAA mutation carriers. Methods D‐CAA mutation carriers (n=8 presymptomatic, n=13 symptomatic, median age 50 years) and (n=9, median age 53 years) controls were scanned using Spectral Domain OCT (SD‐OCT). Symptomatic mutation carriers were defined as having a ...

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    3. Correlation in acute CSCR between hyperreflectivity on the infrared image in optical coherence tomography and fluorescein angiography

      Correlation in acute CSCR between hyperreflectivity on the infrared image in optical coherence tomography and fluorescein angiography

      Background: To determine the association between hyperreflective area identified on the reference image (en-face image) in spectral domain optical coherence tomography (SD-OCT) scan and the leak on fluorescein angiography in patients with acute treatment naive central serous chorioretinopathy (CSCR). Methods: Retrospective, observational chart review. The reference image (en-face) image on SD OCT raster scan was examined for the presence of a hyperreflective spot and an attempt was made to correlate its location on the actual leak seen on FFA using anatomical landmarks as reference. Follow up was 6 months after CSCR resolution. Appropriate statistical analysis was made. Results: Sixty-two patients ...

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    4. Role of wide-angle optical coherence tomography angiography in the detection of clinically non-apparent neovascularisation in proliferative diabetic retinopathy

      Role of wide-angle optical coherence tomography angiography in the detection of clinically non-apparent neovascularisation in proliferative diabetic retinopathy

      Description A 69-year-old man was referred by his physician for a routine fundus evaluation. He was known to have type 2 diabetes mellitus, hypertension and left-sided hemiparesis due to a history of stroke. Best-corrected visual acuity was 20/25; N6 in both eyes. Fundus evaluation indicated the presence of a few microaneurysms in the posterior pole and preretinal haemorrhages, just above the arcades, in both eyes ( figure 1A,B ). He was imaged using wide-angle swept source optical coherence angiography (SS OCTA) 12×12 mm field of view (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA) which showed the presence ...

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    5. Sub-clinical thickening of the fovea in diabetes and its relationship to glycaemic control: a study using swept-source optical coherence tomography

      Sub-clinical thickening of the fovea in diabetes and its relationship to glycaemic control: a study using swept-source optical coherence tomography

      Background Accumulation of multiple pockets of fluid at the fovea, as a complication of poor blood glucose control in diabetes, causes impairment of central vision. A new ability to demonstrate a pre-clinical phase of this maculopathy could be valuable, enabling diabetic individuals to be alerted to the need to improve their glycaemic control. This study aimed to use swept-source optical coherence tomography (SS-OCT) to measure foveal thickness and macular volume in diabetic individuals without cystoid macular oedema, and in non-diabetic individuals, and relate these measures to participants’ glycaemic control. Methods Centre point thickness (CPT) and total macular volume (TMV) were ...

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    6. Intraoperative Optical Coherence Tomography Analysis of Clear Corneal Incision: Effect of the Lateral Stromal Hydration

      Intraoperative Optical Coherence Tomography Analysis of Clear Corneal Incision: Effect of the Lateral Stromal Hydration

      Aim of the Study . The aim of this prospective study was to analyse the effect of lateral stromal hydration on the morphology of clear corneal incision architecture using the microscope integrated anterior segment OCT. Methods . The cohort included 65 clear corneal incisions of 49 patients who underwent cataract surgery. Corneal incisions were recorded using a Leica Proveo 8 microscope with an intraoperative OCT EnFocus™ device continuously during the surgery. Corneal incision morphology before and after lateral stromal hydration was analysed. Results . Good adaptation of the corneal incision before hydration was present in 39 cases (60%), in 16 cases (24.6 ...

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      Mentions: Leica
    7. Optical coherence tomography study of macular structural changes in silicone oil-filled eyes

      Optical coherence tomography study of macular structural changes in silicone oil-filled eyes

      Introduction Silicone oil (SO) has been used in complex cases of retinal detachment with proliferative vitreoretinopathy (PVR), giant retinal tear, and traumatic cases. This study aimed to assess macular structural changes in SO filled eyes after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment with PVR. Patients and methods This is a prospective interventional study that was conducted on 60 SO-filled eyes after successful PPV for rhegmatogenous retinal detachment with grade C PVR; SO was left in all eyes for a duration of 3 months. Thorough ophthalmic evaluation in Ophthalmology Department, Tanta University, Egypt was performed including best corrected visual ...

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    8. Sensitivity of optical coherence tomography and visual evoked potential in demyelinating optic neuritis

      Sensitivity of optical coherence tomography and visual evoked potential in demyelinating optic neuritis

      Aim The aim of this study is to analyze the structural and functional abnormalities of the optic nerve in multiple sclerosis (MS) patients utilizing optical coherence tomography (OCT) and visual evoked potential (VEP). We compare between eyes with and without a history of neuritis. Patients and methods A cross-sectional study which compared 60 eyes of MS patients with 20 eyes of the healthy control group. MS patients were classified into MS with optic neuritis (MS-ON, n =44) and MS without optic neuritis (MS-NON, n =16). Both VEP and OCT were done. Results Both groups showed thinning in the retinal nerve ...

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    9. OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

      OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

      Purpose: To examine optic nerve head (ONH) anatomy in young adults with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) or nonarteritic anterior ischemic optic neuropathy (NA-AION) in order to look for associated, potentially predisposing anomalies. Methods: Cross-sectional study including 54 patients (ages 16–50 years) diagnosed from 2009 to 2018 with CRVO, BRVO, CRAO, BRAO, or NA-AION. Using Optical Coherence Tomography the presence of optic disc drusen (ODD), prelaminar hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures (PHOMS), and determination of scleral canal size, retinal nerve fiber ...

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    10. Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm

      Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm

      Background The ability of deep learning (DL) algorithms to identify eyes with neovascular age-related macular degeneration (nAMD) from optical coherence tomography (OCT) scans has been previously established. We herewith evaluate the ability of a DL model, showing excellent performance on a Korean data set, to generalse onto an American data set despite ethnic differences. In addition, expert graders were surveyed to verify if the DL model was appropriately identifying lesions indicative of nAMD on the OCT scans. Methods Model development data set—12 247 OCT scans from South Korea; external validation data set—91 509 OCT scans from Washington, USA ...

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    11. Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

      Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

      A 50-year-old male presented with recent metamorphopsia in the right eye. Fundus examination revealed bilateral multiple cuticular drusen along with few large colloid drusen (phenotype 3 cuticular drusen). No vitelliform material was evident in the macula in either eye. Fluorescein angiography (FA), indocyanine green angiography (ICGA) did not demonstrate a macular neovascularization (MNV) in either eye. Swept-source optical coherence tomography (SS-OCT) revealed sub-retinal pigment epithelial (RPE) drusen and a clear space beneath the inter-digitation zone and above the RPE-Bruch’s complex. SS-OCTA did not reveal MNV in either eye. The patient was kept under observation, and follow-up at 3 months ...

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    12. An Artificial Intelligence Approach to Assess Spatial Patterns of Retinal Nerve Fiber Layer Thickness Maps in Glaucoma

      An Artificial Intelligence Approach to Assess Spatial Patterns of Retinal Nerve Fiber Layer Thickness Maps in Glaucoma

      Purpose : The purpose of this study was to classify the spatial patterns of retinal nerve fiber layer thickness (RNFLT) and assess their associations with visual field (VF) loss in glaucoma. Methods : We used paired reliable 24-2 VFs and optical coherence tomography scans of 691 eyes from 691 patients. The RNFLT maps were used to determine the RNFLT patterns (RPs) by non-negative matrix factorization (NMF). The RPs were correlated with mean deviation (MD), spherical equivalent (SE), and major blood vessel locations. The RPs were further used to predict the 52 total deviation (TD) values by linear regression compared with models using ...

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    13. Using a dual-tree complex wavelet transform for denoising an optical coherence tomography angiography blood vessel image

      Using a dual-tree complex wavelet transform for denoising an optical coherence tomography angiography blood vessel image

      High image quality is of great importance for precise diagnosis and therapeutics of eye disease in clinic. A human retina OCT angiography (OCTA) image can be extracted from multiple OCT B-scans to visualize the distribution of blood vessels. However, OCTA suffer from the degeneration of image quality due to inherent Gaussian noise of the OCT system while the blood vessel’s signal is extracted. The degeneration of the noise in OCTA image will be more conducive to the evaluation of abnormal and normal blood vessels in the human eye. To precisely assist diagnosis and therapeutics in clinic by reducing the ...

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    14. Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes

      Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes

      We aimed to evaluate choroid structural changes using swept-source optical coherence tomography (SS-OCT) following hemodialysis initiation in diabetic and nondiabetic patients with end-stage kidney disease (ESKD). In this multicenter, prospective, cross-sectional study, diabetic (DM group; 30 eyes; 16 patients) and nondiabetic patients (NDM group; 30 eyes; 15 patients) with ESKD were evaluated after hemodialysis initiation. SS-OCT findings were analyzed using a manual delineation technique and binarization method before the first and last hemodialysis sessions, conducted approximately 2 weeks apart. Subfoveal choroidal thickness changes and mean large choroidal vessel layer thickness were significantly greater in the DM group (−13.3% ± 2 ...

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    15. Comparison of Anterior Ocular Biometric Measurements Using Swept-Source and Time-Domain Optical Coherence Tomography

      Comparison of Anterior Ocular Biometric Measurements Using Swept-Source and Time-Domain Optical Coherence Tomography

      Purpose . To compare central corneal thickness (CCT), aqueous depth (AQD), and anterior chamber depth (ACD) measurements using the swept-source (CASIA SS-1000, Tomey, Japan) and time-domain (Visante, Carl Zeiss Meditec, USA) anterior segment optical coherence tomographers (OCT) in normal eyes. Methods . Sixty-eight eyes of 68 subjects were included. Three consecutive scans of each subject were obtained using both devices in a random order by one experienced operator. Standard deviation ( S w ), coefficient of repeatability (CoR), coefficients of variation (CoV), and intraclass correlation coefficients (ICC) were used to evaluate the intraoperator repeatability. Agreement was assessed using the Bland–Altman plots and 95 ...

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    16. Optical Coherence Tomography Angiography to detect non-exudative neovascular age-related macular degeneration mimicking chronic central serous chorioretinopathy.

      Optical Coherence Tomography Angiography to detect non-exudative neovascular age-related macular degeneration mimicking chronic central serous chorioretinopathy.

      Chronic central serous chorioretinopathy (cCSC) can produce an overlap of signs that can be difficult to distinguish from cases with non-exudative neovascular age-related macular degeneration (nneAMD). Around 2-10% of the patients with cCSC will develop neovascularization. Sometimes both diseases could be present at the same individual. The purpose of this narrative review is to discuss the current information concerning the signs in OCT angiography that eventually could help to differentiate these situations and analyze the best diagnostic evidence.

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    17. Asymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma

      Asymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma

      Macular retinal layer thickness asymmetry indices, particularly for the ganglion cell layer, are promising early indicators of glaucomatous damage. We evaluated macular perfusion density asymmetry (MPDA) among normal, preperimetric glaucoma (PPG), and perimetric glaucoma (PG) eyes, and we tested the performance of MPDA in differentiating between control and glaucoma eyes with or without visual field (VF) defects. In this study, 116 eyes (39 normal, 27 PPG, and 50 PG eyes) with optical coherence tomography angiography images of the macula were analysed. No significant difference was found in outer and inner MPDA between the control and PPG groups. However, outer MPDA ...

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    18. Corneal Remodeling After Myopic SMILE: An Optical Coherence Tomography and In Vivo Confocal Microscopy Study

      Corneal Remodeling After Myopic SMILE: An Optical Coherence Tomography and In Vivo Confocal Microscopy Study

      PURPOSE: To study corneal remodeling during the first 6 months after myopic small incision lenticule extraction (SMILE) with a 10% overcorrection nomogram, by spectral-domain optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM). METHODS: This prospective non-randomized observational study included 60 eyes from 30 patients treated by SMILE for low to moderate myopia. A 10% overcorrection nomogram was applied for all eyes. Epithelial and corneal thickness maps were obtained within the central 6 mm, by SD-OCT, at each visit. Lenticule thickness was calculated by subtracting the postoperative central stromal thickness from the preoperative central stromal thickness. IVCM was performed ...

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    19. Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

      Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

      In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus primates (10 unilateral; 6 bilateral) and assessed the structural changes of the ONH longitudinally to observe early changes. Elevated intraocular pressure (IOP) in OHT eyes was maintained for 7 months ...

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    20. Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab

      Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab

      Purpose This study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME). Methods Twenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively. Results Six-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure ...

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    21. The optoretinogram reveals the primary steps of phototransduction in the living human eye

      The optoretinogram reveals the primary steps of phototransduction in the living human eye

      Photoreceptors initiate vision by converting photons to electrical activity. The onset of the phototransduction cascade is marked by the isomerization of photopigments upon light capture. We revealed that the onset of phototransduction is accompanied by a rapid (<5 ms), nanometer-scale electromechanical deformation in individual human cone photoreceptors. Characterizing this biophysical phenomenon associated with phototransduction in vivo was enabled by high-speed phase-resolved optical coherence tomography in a line-field configuration that allowed sufficient spatiotemporal resolution to visualize the nanometer/millisecond-scale light-induced shape change in photoreceptors. The deformation was explained as the optical manifestation of electrical activity, caused due to rapid charge displacement ...

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    22. Artificial intelligence and deep learning in ophthalmology - present and future (Review)

      Artificial intelligence and deep learning in ophthalmology - present and future (Review)

      Since its introduction in 1959, artificial intelligence technology has evolved rapidly and helped benefit research, industries and medicine. Deep learning, as a process of artificial intelligence (AI) is used in ophthalmology for data analysis, segmentation, automated diagnosis and possible outcome predictions. The association of deep learning and optical coherence tomography (OCT) technologies has proven reliable for the detection of retinal diseases and improving the diagnostic performance of the eye's posterior segment diseases. This review explored the possibility of implementing and using AI in establishing the diagnosis of retinal disorders. The benefits and limitations of AI in the field of ...

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    23. Seeing the Eye Like Never Before

      Seeing the Eye Like Never Before

      While there is no cure for blindness and macular degeneration, scientists have accelerated the process to find a cure by visualizing the inner workings of the eye and its diseases at the cellular level. In an effort led by UW Medicine, researchers successfully modified the standard process of optical coherence tomography (OCT) to detect minute changes in response to light in individual photoreceptors in the living eye. The results were published Sept. 9 in Science Advances . “We have now accelerated the life cycle of vision restoration,” said lead author Vimal Prabhu Pandiyan, a ophthalmology researcher at the University of Washington ...

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    24. Vienna Preserflo Cohort Study

      Vienna Preserflo Cohort Study

      The Vienna Preserflo Microshunt Cohort Study is an observational study with a prospective postoperative examination in all glaucoma patients who had received a Preserflo Microshunt (PMS) as standalone procedure or in combination with cataract extraction in the time period between January and November 2019 at the Department of Ophthalmology, Medical University of Vienna. It is estimated that approximately 70 patients will be included of this cohort. The cohort will be invited for a prospective postoperative examination after 12 (±5) months of follow up. This examination shall comprise best corrected visual acuity, visual field test, intraocular pressure (IOP) measurement, slit lamp ...

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