1. Articles in category: Ophthalmology

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    1. Algorithm for Detection and Quantification of Hyperreflective Dots on Optical Coherence Tomography in Diabetic Macular Edema

      Explore Frontiers Ophthalmology
      Algorithm for Detection and Quantification of Hyperreflective Dots on Optical Coherence Tomography in Diabetic Macular Edema

      Purpose: To develop an algorithm to detect and quantify hyperreflective dots (HRDs) on optical coherence tomography (OCT) in patients with diabetic macular edema (DME). Materials and Methods: Twenty OCTs (each OCT contains 128 b scans) from 20 patients diagnosed with DME were included in this study. Two types of HRDs, hard exudates and small HRDs (hypothesized to be activated microglia), were identified and labeled independently by two raters. An algorithm using deep learning technology was developed based on input (in total 2,560 OCT b scans) of manual labeling and differentiation of HRDs from rater 1. 4-fold cross-validation was used ...

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      Mentions: The Chinese University of Hong Kong Soochow University

    2. Intraoperative OCT versus Scheimpflug and Swept-Source OCT measurements for anterior eye parameters

      Explore LWW Online Ophthalmology
      Intraoperative OCT versus Scheimpflug and Swept-Source OCT measurements for anterior eye parameters

      Purpose: To compare agreement of anterior segment parameter measurements using an intraoperative optical coherence tomography (iOCT) of a femtosecond laser (LenSx) during interface docking to the eye to preoperative Scheimpflug-tomography (Pentacam AXL) and swept-source optical coherence tomography (IOL Master 700). Setting: Department of Ophthalmology, Goethe University, Frankfurt, Germany. Design: Retrospective study. Methods: Ninty-five eyes of 66 patients who had planned OCT-guided femtosecond laser-assisted lens surgery were included. Anterior segment measurements were performed in mydriasis prior to surgery using Scheimpflug-tomography and swept-source optical coherence tomography. After surgery iOCT images were analysed using a modification of the FIJI image processing program. Outcome ...

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      Mentions: Harvard University Alcon

    3. Evaluation of intra-operative aphakic axial eye length measurements using swept source optical coherence tomography

      Explore LWW Online Ophthalmology
      Evaluation of intra-operative aphakic axial eye length measurements using swept source optical coherence tomography

      Purpose: Evaluation of intra-operative aphakic axial eye length (AL) measurements using swept source optical coherence tomography. Setting: Hanusch Hospital, Vienna, Austria. Design: Prospective single-center study. Methods: Patients scheduled for cataract surgery were measured using swept-source optical coherence tomography (ss-OCT, IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany) to assess the axial eye length. Intra-operatively, swept source optical coherence tomography (ss-OCT) measurements were performed with a prototype device (IOLMaster 700 connected to an OPMI Lumera 700 microscope, CZM) at the beginning of cataract surgery furthermore of the aphakic eye and 2 months after surgery. Results: Of the 59 eyes of 59 ...

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      Mentions: Carl Zeiss Meditec

    4. Evaluation of impact of posterior phakic intraocular lens implantation on biometry and effectiveness of concomitant use of anterior segment optical coherence tomography on intraocular lens power calculation for cataract surgery

      Explore LWW Online Ophthalmology
      Evaluation of impact of posterior phakic intraocular lens implantation on biometry and effectiveness of concomitant use of anterior segment optical coherence tomography on intraocular lens power calculation for cataract surgery

      Purpose: To evaluate the effects of phakic intraocular lens (pIOL) implantation on the IOL power calculation, and subsequently to evaluate the effectiveness of concomitant use of anterior segment optical coherence tomography (AS-OCT) against biometric changes. Setting: Masayuki Ouchi Eye Clinic, Kyoto, Japan. Design: Prospective consecutive case series. Methods: One hundred patients (100 eyes) who underwent pIOL implantation were enrolled. In each eye, biometry was performed using partial coherence interferometry (PCI) and anterior segment optical coherence tomography (AS-OCT). Pre- and post-pIOL implantation IOL power calculation using SRK/T (S), Haigis (H), and Barret Universal [Combining Enclosing Square] (B) formulae were compared ...

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    5. Evaluation of choroidal thickness in children with acute asthma attack by optical coherence tomography

      Explore SAGE Journals Ophthalmology
      Evaluation of choroidal thickness in children with acute asthma attack by optical coherence tomography

      Objective: To evaluate the change in central choroidal thickness in children with asthma attack before and after treatment with β 2 agonists. Materials and methods: About 100 eyes of 50 patients (5-17 years old) with visual acuity of 20/20 who had no retinal, choroidal, and systemic comorbidity were examined by enhanced depth optical coherence tomography (EDI-OCT) before and after asthma attack treatment. Sixty eyes of 30 healthy children of similar age and gender were evaluated as the control group. The central choroidal thickness, peak expiratory flow (PEF), forced expiratory volume 1(FEV 1 ), oxygen saturation, and heart rate were evaluated ...

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    6. To evaluate the microcirculation of retinochoroid capillary between acute and chronic central serous chorioretinopathy with OCTA

      Explore LWW Online Ophthalmology
      To evaluate the microcirculation of retinochoroid capillary between acute and chronic central serous chorioretinopathy with OCTA

      To investigate the difference in chorioretinal microcirculation between acute central serous chorioretinopathy (aCSC) and chronic central serous chorioretinopathy (cCSC) using optical coherence tomography angiography.In total, 65 patients previously diagnosed with central serous chorioretinopathy (33 aCSC and 32 cCSC) were included in our cross-sectional study. All patients underwent complete ophthalmologic assessment including logarithm of the minimum angle of resolution best-corrected visual acuity, fundus fluorescein angiography, and optical coherence tomography angiography. Sixty eyes of 60 refractive error and age matched healthy people were selected as control.The vessel density of inner retina in patients with aCSC were higher than that in ...

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    7. Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives a 2021 NIH Grant for $582,395 for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging. The principal investigator is Nathan Doble. Below is a summary of the proposed work. The proposed design and construction of an optical coherence tomography (OCT) system, namely, a full-field (FF)-swept-source (SS)-OCT will allow rapid structural and functional measures of individual cone and rod photoreceptors (PRCs), the sub-retinal space (SRS) and retinal pigment epithelial (RPE) cells to an external light stimulus. Current OCT systems either have limited temporal resolution i.e. they are not fast enough ...

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      Mentions: National Institutes of Health The Ohio State University

    8. Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives a 2021 NIH Grant for $471,602 for OCT Angiography for Neovascular Age-related Macular Degeneration. The principal investigator is Yali Jia. Below is a summary of the proposed work. Neovascular age-related macular degeneration (AMD), characterized by the presence of choroidal neovascularization (CNV), accounts for the majority of AMD related vision loss. Invasive dye-based fluorescein angiography (FA) remains the gold standard for CNV detection. Using high-speed OCT systems, we have developed novel OCT angiography (OCTA) technologies to image CNV as well as vascular plexuses associated with AMD. Our recent clinical studies have demonstrated that (1 ...

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      Mentions: National Institutes of Health Oregon Health & Science University Center for Ophthalmic Optics and Lasers

    9. University of California at Los Angeles Receives NIH Grant for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery.

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      University of California at Los Angeles Receives NIH Grant for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery.

      University of California at Los Angeles Receives a 2021 NIH Grant for $557,751 for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery. The principal investigator is Jean-Pierre Hubschman. Below is a summary of the proposed work. The long-term goals of the present study are to improve surgical outcomes and reduce the risk of surgical complications of cataract surgery. It is our central hypothesis that intraoperative stabilization of the ocular structures, complete lens extraction, and accurate positioning of the intraocular lens implant through robotic manipulations and optical coherence tomography (OCT) feedback will significantly improve the safety of critical ...

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      Mentions: National Institutes of Health UCLA

    10. New England College of Optometry Receives NIH Grant for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      New England College of Optometry Receives NIH Grant for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo

      New England College of Optometry Receives a 2021 NIH Grant for $196,651 for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo. The principal investigator is Ji Change He. Below is a summary of the proposed work. The crystalline lens of the human eye grows throughout life with continuous change in its size, shape and internal structure. The lifetime growth of the lens generates a special structure inside the lens: the gradient distribution. From the lens surface to the lens center, the gradient distribution is characterized ...

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      Mentions: National Institutes of Health

    11. Detection of Hard Exudate using Retinal Optical Coherence Tomography (OCT) Images

      Explore ScienceDirect Ophthalmology
      Detection of Hard Exudate using Retinal Optical Coherence Tomography (OCT) Images

      To distinguish DR retinal one device is utilized called Optical Coherence Tomography (OCT). So to break down hard exudates (HEs) and their antecedents in patients with diabetic retinopathy (DR) by utilizing Optical Coherence Tomography (OCT) pictures is fundamental. Hard Exudates (HEs) are one kind of principle sign of DR. It is the back shaft of an eye with macular edema. Modified acknowledgment of HE from the retinal picture is a critical development for the area of DR. HE is an essential in the eye for those having diabetes. This Hard Exudates can provoke visual weakness if not managed before all ...

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    12. Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets

      Explore OSA | OSA Publishing Ophthalmology
      Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets

      We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image. With the OCT and fluorescence images of the reference targets, the effects of illumination ...

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      Mentions: University of Miami Florida International University

    13. CDC-Net: Cascaded decoupled convolutional network for lesion-assisted detection and grading of retinopathy using optical coherence tomography (OCT) scans

      Explore ScienceDirect Ophthalmology
      CDC-Net: Cascaded decoupled convolutional network for lesion-assisted detection and grading of retinopathy using optical coherence tomography (OCT) scans

      Retinopathy refers to any injury in the retinal region of the eye that can lead to distorted vision or even blindness. The segmentation of retinal lesions or biomarkers is crucial for the precise classification and grading of retinopathy. Optical coherence tomography imaging is the widely used eye examination tool by ophthalmologists due to its comprehensive visualization of the retinal lesions, which can assist in the prompt treatment of retinal conditions. However, due to vast clinical optical coherence tomography applications and the incidence of ocular syndromes, the number of scans collected daily outweighs ophthalmologists’ capacity to interpret these in a meaningful ...

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    14. Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in Multiple Sclerosis Patients

      Explore Taylor & Francis Online Ophthalmology
      Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in Multiple Sclerosis Patients

      In addition to ocular neurodegeneration in multiple sclerosis (MS), accompanying microvascular changes in the retina are thought to occur. In this study we sought to compare retinal neurodegenerative changes using optical coherence tomography (OCT) and microvascular changes using OCT angiography (OCTA) of MS patients and healthy controls. This cross-sectional study included 164 eyes of 83 MS patients and 114 eyes of 57 healthy control subjects. There were significant differences in retinal nerve fibre layer (RNFL), ganglion cell complex (GCC), and radial peripapillary capillary (RPC) vessel density (VD) between the MS group and the control group, but no significant differences in ...

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    15. Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT)

      Explore OSA | OSA Publishing Ophthalmology
      Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT)

      Ocular deformation may be associated with biomechanical alterations in the structures of the eye, especially the cornea and sclera in conditions such as keratoconus, congenital glaucoma, and pathological myopia. Here, we propose a method to estimate ocular shape using an ultra-wide field MHz swept-source optical coherence tomography (SS-OCT) with a Fourier Domain Mode-Locked (FDML) laser and distortion correction of the images. The ocular biometrics for distortion correction was collected by an IOLMaster 700, and localized Gaussian curvature was proposed to quantify the ocular curvature covering a field-of-view up to 65°×62°. We achieved repeatable curvature shape measurements (intraclass coefficient = 0 ...

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      Mentions: Duke University Columbia University Singapore Eye Research Institute

    16. High-Speed, Long-Range Swept-Source Optical Coherence Tomography for the Anterior Segment of the Eye

      Explore IOVS Journal Ophthalmology
      High-Speed, Long-Range Swept-Source Optical Coherence Tomography for the Anterior Segment of the Eye

      Purpose : The anterior segment (AS) of the eye is of interest in multiple diseases and procedures, including glaucoma, ocular surface inflammation, and refractive / cataract surgeries. Visualizing the anterior eye using optical coherence tomography (OCT) has unique challenges, and AS OCT technology is less developed than retinal imaging. We developed next generation swept-source OCT (SS-OCT) technology to enable high-speed and long-range AS structural and angiographic imaging in clinical settings. Methods : We designed a SS-OCT prototype instrument using wavelength-tunable, vertical-cavity surface-emitting laser (VCSEL) with linearized frequency sweep. The OCT wavelength centers at 1310 nm with a 105 nm bandwidth. The A-scan rate ...

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      Mentions: Thorlabs Massachusetts General Hospital Oregon Health & Science University

    17. MHz Swept Source Optical Coherence Tomography of the Choriocapillaris

      Explore IOVS Journal Ophthalmology
      MHz Swept Source Optical Coherence Tomography of the Choriocapillaris

      Purpose : Resolving individual capillaries of the choriocapillaris with swept source optical coherence tomography (SS-OCT) angiography is challenging and has so far been limited to very small field of views (FOV). We present a MHz SS-OCT prototype, which provides high-contrast choriocapillaris (CC) images. Methods : We developed a 1060 nm SS-OCT prototype, capable of A-scan rates up to 1.7 MHz. Its lateral resolution was 7.8 μm and its axial resolution was 9 μm in tissue. We acquired Angio 12 mm x 12 mm scans with a sampling of 1024 (A-scans) x 1024 (B-scans) x 4 (B-scan repetitions) and Angio 2 ...

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      Mentions: Medical University of Vienna Carl Zeiss Meditec

    18. The promising retinal optical coherence tomography biomarkers in common macular diseases: A brief summary of the literature

      Explore European Eye Research Ophthalmology
      The promising retinal optical coherence tomography biomarkers in common macular diseases: A brief summary of the literature

      The recent developments in imaging technologies such as optical coherence tomography (OCT) helped produce high-quality and high-resolution retinal images. This progress revealed some parameters called biomarkers, which are helpful clinical decision-making indicators. This review aims to highlight valuable OCT biomarkers related to common macular diseases. Besides the most frequent disorders such as diabetic retinopathy and age-related macular degeneration, also retinal vein occlusion and epiretinal membrane were evaluated in the current article. The mentioned markers can help determine prognosis, assess treatment response, and even predict surgical success; however, there is a need for wider and prospective studies. It is essential to ...

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    19. Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT

      ackground: To present a series of acute central retinal artery occlusion (CRAO) cases showing internal limiting membrane detachment (ILMD) on optical coherence tomography (OCT) and to describe the possible etiopathogenesis and outcomes associated with it. Methods: Demographic and OCT features of patients with acute CRAO were analysed retrospectively. OCT parameters noted were posterior vitreous opacities, ILMD, inner retinal layer stratification, hyperreflectivity and thickening, cystoid macular edema, neurosensory detachment. Eyes were grouped into Group (1) CRAO with ILMD; Group (2) CRAO with no ILMD. Results: A total of 28 eyes of acute CRAO who had undergone OCT scans at the time ...

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      Mentions: University of Pittsburgh

    20. Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

      Explore Nature Publishing Group Ophthalmology
      Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

      Post fever retinitis is a heterogenous entity that is seen 2-4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to fundus fluorescein angiography to image the retinal microvasculature. We hereby describe the vascular changes during the acute phase of post fever retinitis on OCTA. Imaging on OCTA was done for all patients with post fever retinitis at presentation with 3 × 3 mm and 8 × 8 mm scans centred on the macula and corresponding enface optical coherence ...

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    21. Retinal Vessel Density Changes on Optical Coherence Tomography Angiography and Predictive Factors in Normal-Tension Glaucoma Treated with Topical Beta-Blocker

      Explore MDPI Open Access Journals Platform Ophthalmology
      Retinal Vessel Density Changes on Optical Coherence Tomography Angiography and Predictive Factors in Normal-Tension Glaucoma Treated with Topical Beta-Blocker

      (1) Background: Topical antiglaucoma medications may alter the microcirculation in the optic nerve head. We aimed to evaluate the changes in retinal vessel density (VD) on optical coherence tomography angiography (OCTA) in patients with newly diagnosed normal-tension glaucoma (NTG) treated with a topical beta-blocker. (2) Methods: This study included 80 patients diagnosed with NTG not using systemic medication, who received topical carteolol treatment between December 2019 and November 2020. We studied the changes in the OCTA VD/signal strength index (SSI) after the 6-month treatment period and determined the predictive factors affecting the changes in VD/SSI. (3) Results: After ...

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      Mentions: Chang Gung University

    22. Optical Coherence Tomography based indices in predicting functional outcome of macular hole surgery: A retrospective chart review

      Explore Pakistan Journal of Medical Sciences Ophthalmology
      Optical Coherence Tomography based indices in predicting functional outcome of macular hole surgery: A retrospective chart review

      Objectives: The objective of this study was to assess the utility of novel macular hole indices of Optical Coherence Tomography (OCT) and predicting the functional outcome of surgery. Methods: This was a retrospective chart review of 28 eyes who underwent surgery for idiopathic Full Thickness Macular Hole (FTMH) at The Aga Khan University Hospital (AKUH), Karachi from January 2016 to March 2020. Data of preoperative OCTs were recovered from data server of OCT machine. Measurements of the pre-operative OCTs were calculated using caliper function of OCT software by two independent technicians. Parameters included Macular Hole Index (MHI), Traction Hole Index ...

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    23. Macular Structure and Microvasculature Changes in AIDS-Related Cytomegalovirus Retinitis Using Optical Coherence Tomography Angiography

      Explore Frontiers Ophthalmology
      Macular Structure and Microvasculature Changes in AIDS-Related Cytomegalovirus Retinitis Using Optical Coherence Tomography Angiography

      Background: Cytomegalovirus retinitis (CMVR) is a crucial blind-causing disease of AIDS-related ocular opportunistic infection. The CMVR lesions produced retinal necrosis. It is not entirely clear whether CMVR eyes without macular-involved necrotic lesions may have subtle macular damage. In this study, we conducted a cross-sectional study using optical coherence tomography angiography (OCTA) to evaluate macular microvasculature and structure in eyes with AIDS-related CMVR. Methods: Acquired immune deficiency syndrome (AIDS)-related CMVR patients (active and inactive CMVR) and healthy controls treated in the Department of Ophthalmology, Beijing Youan Hospital, Capital Medical University between August 25, 2019, and October 18, 2019, were recruited ...

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      Mentions: Capital Medical University

    24. Optical coherence tomography angiography in amblyopia: A critical update on current understandings and future perspectives

      Explore SAGE Journals Ophthalmology
      Optical coherence tomography angiography in amblyopia: A critical update on current understandings and future perspectives

      Optical coherence tomography angiography (OCTA) is a non-invasive tool to assess the retino-choroidal vasculature in vivo. It tracks the red blood cell movement and maps the vasculature in quick succession. In routine, diabetic retinopathy, age related macular degeneration, central serous chorioretinopathy, and others are commonly being studied to unveil its clinic role. On the other hand, amblyopia is a condition where the visual acuity is subnormal due to non-organic causes in the eye. But the OCTA studies till now have shown variable changes along retino-choroidal vasculature. Hence, to comprehend the existing literature knowledge, a systematic literature search was carried out ...

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