1. Articles in category: Ophthalmology

    25-48 of 12388 « 1 2 3 4 5 ... 515 516 517 »
    1. Topography and pachymetry maps for mouse corneas using optical coherence tomography

      Topography and pachymetry maps for mouse corneas using optical coherence tomography

      The majority of the eye's refractive power lies in the cornea, and pathological changes in its shape can affect vision. Small animal models offer an unparalleled degree of control over genetic and environmental factors that can help elucidate mechanisms of diseases affecting corneal shape. However, there is not currently a method to characterize the corneal shape of small animal eyes with topography or pachymetry maps, as is done clinically for humans. We bridge this gap by demonstrating methods using optical coherence tomography (OCT) to generate the first topography and pachymetry (thickness) maps of mouse corneas. Radii of curvature acquired ...

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    2. Comparison of Short- And Long-Term Variability On Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma

      Comparison of Short- And Long-Term Variability On Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma

      Purpose To assess short-term and long-term variability on standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT) in glaucoma. Design Prospective cohort. Methods Ordinary least squares linear regression of SAP mean deviation (MD) and SD-OCT global retinal nerve fiber layer (RNFL) thickness were fitted over time for sequential tests conducted within 5 weeks (short-term testing) and annually (long-term testing). Residuals were obtained by subtracting the predicted and observed values and each patient’s standard deviation (SD) of the residuals was used as a measure of variability. Wilcoxon signed-rank test was performed to test the hypothesis of equality between ...

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    3. Chronic Neovascular Central Serous Chorioretinopathy: A Stress/Rest Optical Coherence Tomography Angiography Study

      Chronic Neovascular Central Serous Chorioretinopathy: A Stress/Rest Optical Coherence Tomography Angiography Study

      Purpose To compare optical coherence tomography–angiography performed during physical exercise (stress OCT-A) to the basal examination (rest OCT-A) in the imaging of choroidal neovascularization (CNV) in patients with chronic central serous chorioretinopathy (CSCR). Design Prospective, cohort study. Methods This multicenter study included 29 consecutive patients with chronic CSCR and flat irregular pigment epithelium detachments (FIPEDs). All patients underwent rest and stress OCT-A (i.e., hand-grip test [HGT]). Systemic hemodynamic data were recorded during the examinations. Rest and stress OCT-angiograms in the en-face and cross-sectional views were qualitatively compared to establish the degree of evidence of flow signals due to ...

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    4. Evaluation of Visual Evoked Potential and Optical Coherence Tomography Results in Idiopathic Parkinson’s Disease Patients

      Evaluation of Visual Evoked Potential and Optical Coherence Tomography Results in Idiopathic Parkinson’s Disease Patients

      Objectives: This study evaluates Visual Evoked Potential (VEP) and Optical Coherence Tomography (OCT) in Idiopathic Parkinson’s Disease (PD) Patients; analyzes the relation between the disease’s severity and such values, and investigates the presence of interocular asymmetry in patients with one-sided dominance. Methods: 40 eyes of 20 PD patients at various stages were evaluated. The disease’s severity was measured via UPDRS (Unified Parkinson’s Disease Rating Scale) and Hoehn&Yahr (H&Y) scales. Results: There were 21 (52%) eyes with a pathological P100 latency. P100 latency prolonged as the H&Y staging went up; however, it was not ...

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    5. The effect of image quality on the reliability of OCT angiography measurements in patients with diabetes

      The effect of image quality on the reliability of OCT angiography measurements in patients with diabetes

      Background This study aimed to determine the relationship between image quality and measurement repeatability of optical coherence tomography angiography (OCTA) parameters in patients with non-proliferative diabetic retinopathy. Methods A total of 100 eyes of 50 patients were included in the study. Three OCTA images were obtained consecutively during one session of imaging in all patients using the RTVue AngioVue OCTA device. We applied the signal strength index (SSI) provided by the RTVue system to define scan quality. Superficial vessel density (VD) in the central 3 × 3 mm macular and in the perifoveal region, as well as foveal avascular zone (FAZ ...

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    6. Changes in choroidal vascular parameters following pan-retinal photocoagulation using swept-source optical coherence tomography

      Changes in choroidal vascular parameters following pan-retinal photocoagulation using swept-source optical coherence tomography

      Background To assess the effect of pan-retinal photocoagulation (PRP) on choroidal vascular parameters in eyes with advanced diabetic retinopathy (DR). Methods Forty patients (65 eyes) with severe nonproliferative DR or proliferative DR who underwent PRP were included. Changes in choroidal vascular parameters were assessed at 3, 6, and 12 months after PRP by using swept-source optical coherence tomography (OCT) and OCT angiography and were compared with baseline values. Results Choroidal vascularity index (CVI) significantly decreased from 66.27% ± 1.55% at baseline to 65.85% ± 1.61%, 65.77% ± 1.29%, and 65.74% ± 1.60% at 3, 6, and ...

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    7. Characterisation of vascular changes in different stages of Stargardt disease using double swept-source optical coherence tomography angiography

      Characterisation of vascular changes in different stages of Stargardt disease using double swept-source optical coherence tomography angiography

      Objective To describe vascular changes in different stages of Stargardt disease (STGD) via double swept-source optical coherence tomography angiography. Methods and analysis Prospective, cross-sectional case–control study. Twenty-three patients (45 eyes) with ABCA4 mutations graded according to the Fishman STGD classification and 23 controls (23 eyes) were included. Two independent investigators quantified the foveal avascular zone (FAZ) in the superficial and deep capillary plexus (SCP/DCP) and the areas presenting rarefied flow and complete vascular atrophy in the outer retina to choriocapillaris (ORCC) and choriocapillaris (CC) slab. Results The mean age at first diagnosis of STGD was 24.0 years ...

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    8. Structural Retinal Assessment Using Optical Coherence Tomography and Fundus Fluorescein Angiography in Systemic Lupus Erythematosus Patients

      Structural Retinal Assessment Using Optical Coherence Tomography and Fundus Fluorescein Angiography in Systemic Lupus Erythematosus Patients

      Background Ocular manifestations in systemic lupus erythematosus ( SLE ) can be the presenting symptom of the disease or a sight-threatening complication. Objectives To detect different structural retinal changes in patients with SLE who had no ophthalmological symptoms and investigate the relationship between different retinal changes and the disease activity assessed by the Systemic Lupus Erythromatosus Disease Activity Index score. Study Design A descriptive pilot study from January 2016 to January 2017. Methods Fifty-two eyes of 26 patients diagnosed to have SLE were examined using visual acuity assessment, fundus examination, optical coherence tomography (OCT), and fundus fluorescein angiography (FFA). Results Fundus fluorescein ...

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    9. A NOVEL FINDING OF HYPERREFLECTIVE MATERIAL IN THE SILICONE-RETINA INTERFACE An Optical Coherence Tomographic and Histopathological Study

      A NOVEL FINDING OF HYPERREFLECTIVE MATERIAL IN THE SILICONE-RETINA INTERFACE An Optical Coherence Tomographic and Histopathological Study

      Purpose: To describe novel findings of hyperreflective material in the silicone-retina interphase on spectral domain optical coherence tomography (SD-OCT) imaging in eyes with silicone oil tamponade. Methods: Retrospective observational clinical study of consecutive patients who underwent primary pars plana vitrectomy with silicone oil tamponade for rhegmatogenous retinal detachment. Repeat clinical examination and spectral domain optical coherence tomography macular imaging performed 3 months after surgery were evaluated to identify any macular pathologies, including formation of epiretinal membranes, intraretinal changes, subretinal fluid, and edema before scheduled secondary vitrectomy for silicone oil removal. Results: Eighty-two patients (mean age 54 years, range 22–89 ...

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    10. Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis

      Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis

      Background Retinal optical coherence tomography (OCT) is a clinical and research tool in multiple sclerosis, where it has shown significant retinal nerve fiber (RNFL) and ganglion cell (RGC) layer thinning, while postmortem studies have reported RGC loss. Although retinal pathology in experimental autoimmune encephalomyelitis (EAE) has been described, comparative OCT studies among EAE models are scarce. Furthermore, the best practices for the implementation of OCT in the EAE lab, especially with afoveate animals like rodents, remain undefined. We aimed to describe the dynamics of retinal injury in different mouse EAE models and outline the optimal experimental conditions, scan protocols, and ...

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      Mentions: Ari J. Green
    11. Anterior-Segment Optical Coherence Tomography–Guided Measurement Of A Melting Ulcer For Follow-Up Of Corneoscleral Thinning Progression

      Anterior-Segment Optical Coherence Tomography–Guided Measurement Of A Melting Ulcer For Follow-Up Of Corneoscleral Thinning Progression

      Purpose: To evaluate the feasibility of using anterior-segment optical coherence tomography (AS-OCT) for three-dimensional assessment of corneoscleral thinning progression in ulcers after pterygium removal. Methods: A patient with corneoscleral melting after pterygium removal surgery and mitomycin C treatment was evaluated using AS-OCT imaging of the corneoscleral ulcer at five consecutive time points, up to 2 years. AS-OCT scans of 8.3×5.6 mm (15°×10°) containing 41 B-scans spaced 139 μm apart were performed monthly for 4 months and then at 2 years following pterygium removal. A single B-scan was comprised of 768 A-scans. Ten B-scans of the same ...

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    12. Fire Ant Punctate Keratopathy A Novel Diagnosis Based on Clinical and Anterior Segment Optical Coherence Tomography Findings

      Fire Ant Punctate Keratopathy A Novel Diagnosis Based on Clinical and Anterior Segment Optical Coherence Tomography Findings

      Purpose: To describe the ocular findings and the long-term outcomes of patients diagnosed with corneal injury due to little fire ants (LFAs). Methods: This is a retrospective case series of patients evaluated with corneal injury due to LFAs from October 2015 to January 2018 at the Cornea Clinic in Meir Medical Center. Patients underwent anterior segment optical coherence tomography ( AS-OCT ) imaging during the follow-up. Results: Four patients reported ocular contact with LFAs and presented to our department with unilateral, scattered, small, dense, round, bright white opacities in the anterior corneal stroma, which remained unchanged in appearance over time, despite topical ...

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    13. Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs

      Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs

      Purpose: To perform a comprehensive clinical, diagnostic, and imaging characterization of the ocular surface in West Highland White Terriers (WHWTs) diagnosed with aqueous deficient dry eye (ADDE) disease. Methods: Six ADDE-affected and 13 ADDE-unaffected WHWT dogs were enrolled and underwent clinical assessment and disease scoring, tear osmolarity, phenol red thread test, Schirmer tear test, tear film breakup time, fluorescein staining, Rose bengal and lissamine green vital dye staining, meibometry, corneal esthesiometry, ultrasound pachymetry, optical coherence tomography, in vivo confocal microscopy, and conjunctival biopsy. Subjective assessment of their condition was provided by owner-reported surveys. Results: ADDE-affected WHWT dogs had higher median ...

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    14. Segmentation Guided Registration for 3D Spectral-Domain Optical Coherence Tomography Images

      Segmentation Guided Registration for 3D Spectral-Domain Optical Coherence Tomography Images

      Medical image registration can be used for combining information from multiple imaging modalities, monitoring changes in size, shape or image intensity over time intervals. However, the development of such technique can be challenging for 3D spectral-domain optical coherence tomography (SD-OCT) imaging, because SD-OCT image is inherently noisy and its high resolution leads to high complexity of non-rigid registration. In this paper, a new segmentation guided approach is reported for registration of retinal OCT data. The proposed method models the 3D registration as a two-stage registration including x-y direction registration and z direction registration. In x-y direction registration, the vessel maps ...

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    15. Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment

      Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment

      Purpose To assess the accuracy of macular spectral domain optical coherence tomography (OCT) in detecting complete posterior vitreous detachment (PVD). Design Evaluation of diagnostic test or technology using a retrospective comparative study. Subjects 175 eyes in 175 patients (111 female, 64 male; mean age = 65 years) with pre-operative OCT within 90 days of vitrectomy. Methods PVD status on preoperative macular OCT was compared to PVD determination during vitrectomy. Attached vitreous was identified on OCT by visualizing the posterior vitreous cortex or the premacular bursa. Complete PVD was identified by the absence of these findings, and was considered a positive outcome ...

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    16. VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARING NORMAL AND OPTIC DISK PIT EYES

      VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARING NORMAL AND OPTIC DISK PIT EYES

      Purpose: Optic disk pits (ODPs) are typically detected incidentally as small, gray, unilateral, oval-shaped excavation in the temporal optic disk on routine fundus examination. In this cross-sectional retrospective case series, we report optical coherence tomography angiography findings in patients with unilateral ODPs and describe changes in vessel perfusion associated with ODP. Methods: A total of eight eyes (four with ODP and four normal contralateral) were included in this study. Patients were excluded if any other optic disk abnormalities were present. Spectral-domain optical coherence tomography angiography (AngioVue; Optovue, Fremont, CA) imaging was conducted to map the vascularization of three layers in ...

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    17. Nailfold capillaroscopy with a commercially available optical coherence tomography angiography for ophthalmic use

      Nailfold capillaroscopy with a commercially available optical coherence tomography angiography for ophthalmic use

      Visualising capillaries in the retina and the nailfold provides an opportunity to improve our understanding of various systemic disorders including cardiovascular, metabolic, rheumatic, and eye diseases.1–5 Traditional nailfold capillaroscopy has been primarily utilised, during the last 40 years, to study the vascular components of connective tissue diseases.6,7 It has been established as a safe and noninvasive diagnostic tool that allows high magnification view of skin microcirculation as well assessment of capillary density and blood flow velocity.8,9 In ophthalmology, a number of studies have been conducted to assess eye diseases and their relationship with nailfold ...

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    18. A Common Outer Retina Change in Retinal Degeneration by Optical Coherence Tomography Can Be Used to Assess Outcomes of Gene Therapy

      A Common Outer Retina Change in Retinal Degeneration by Optical Coherence Tomography Can Be Used to Assess Outcomes of Gene Therapy

      Identifying early disease hallmarks in animal models with slow disease progression may expedite disease detection and assessment of treatment outcomes. Using optical coherence tomography (OCT), a widely applied non-invasive method for monitoring retinal structure changes, we analyzed retinal optical sections from six mouse lines with retinal degeneration caused by mutations in different disease-causing genes. While images from wild-type mice revealed four well-separated hyperreflective bands in the outer retina (designated as outer retina reflective bands, ORRB) at all ages, the second (ORRB2) and the third band (ORRB3) were merged in retinas of five mutant mouse lines at early ages, suggesting the ...

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    19. Peripapillary microvasculature in patients with diabetes mellitus: An optical coherence tomography angiography study

      Peripapillary microvasculature in patients with diabetes mellitus: An optical coherence tomography angiography study

      To evaluate changes in peripapillary microvascular parameters in diabetes mellitus (DM) patients using optical coherence tomography angiography (OCTA). Seventy-one diabetic patients (40 in the no diabetic retinopathy [DR] group and 31 in the non-proliferative DR [NPDR] group) and 50 control subjects. OCTA (Zeiss HD-OCT 5000 with AngioPlex) 6 × 6 mm scans centered on the optic disc were analyzed. Peripapillary vessel density (VD), perfusion density (PD) in superficial capillary plexus (SCP) were automatically calculated. The average macular ganglion cell-inner plexiform layer (mGC-IPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses of the no DR and NPDR groups were significantly thinner than ...

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    20. Computational-imaging-based optical coherence tomography in time- and frequency-domain

      Computational-imaging-based optical coherence tomography in time- and frequency-domain

      A computational 3D imaging system is developed that enables polychromatic, depth-resolved, diffraction-limited imaging of semi-transparent objects. By combining coherent diffractive imaging (CDI) and optical coherence tomography (OCT), we reconstruct tomographic images of 3D objects from a set of wavelength- and phase-resolved diffraction patterns, using numerical methods to achieve image quality beyond the hardware limits of the optical systems used. We implement both time- and frequency-domain versions of full-field OCT systems, and for both versions we demonstrate fully lensless, as well as high-numerical-aperture configurations. We provide a comparison and overview of these different practical approaches to depth-resolved computational imaging. Furthermore, we ...

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    21. Comparison of angle-to-angle distance using three devices in normal eyes

      Comparison of angle-to-angle distance using three devices in normal eyes

      Purpose To compare the angle-to-angle (ATA) distance, and the repeatability and the reproducibility of these measurements among the three devices. Methods We performed the ATA measurements in 26 healthy subjects using anterior segment optical coherence tomography (CASIA2, Tomey, Japan), the Scheimpflug camera (Pentacam HR, Oculus, Wetzlar, Germany), and the combined Placido-ring corneal topography and Scheimpflug camera (TMS-5, Tomey). We also compared the repeatability and the reproducibility of the ATA measurements among these three devices. Results The ATA in the CASIA2 group was significantly larger than that in the Pentacam group (Bonferroni test, p  = 0.002), or that in the TMS-5 ...

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