1. Articles in category: Ophthalmology

    25-48 of 13417 « 1 2 3 4 5 ... 557 558 559 »
    1. Posterior capsule rupture with FLACS due to erroneous interpretation of a high OCT intensity area in anterior vitreous

      Posterior capsule rupture with FLACS due to erroneous interpretation of a high OCT intensity area in anterior vitreous

      Purpose We describe a case of posterior capsule rupture during femtosecond laser-assisted cataract surgery (FLACS) due to direct exposure of the posterior capsule to the laser beam. Observations A 47-year-old man underwent FLACS for anterior capsule opacity. The CATALYS® system automatically detected the posterior capsule from the optical coherence tomography (OCT) images, after which the operator manually adjusted the line of posterior capsule. Femtosecond laser irradiation was presumed to be completed successfully. However, upon insertion of a phaco-tip, the diced nucleus of the lens dropped into the vitreous chamber. Reviewing intraoperative OCT images of the treatment summary to check the ...

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    2. Optical coherence tomography angiography cyclic remodeling of CNV in patients affected by Best macular dystrophy

      Optical coherence tomography angiography cyclic remodeling of CNV in patients affected by Best macular dystrophy

      Purpose To evaluate the effect of photodynamic therapy and/or intravitreal injections on choroidal neovascularization in treatment-naïve patients affected by Best Macular Dystrophy using OCT-A Materials and Methods BMD patients with CNV treated using PDT and/or IV were included in the study. All patients underwent a complete ophthalmological examination, OCT and 3 × 3 mm OCT-A. The OCT-A images were analyzed using an open-source software (ImageJ) to assess the CNV membrane area (CNV-MA), the CNV vessel area (CNV-VA), and vessel density (VD) at the follow-ups (3 months after PDT and 1 month after IV). Results Five eyes of four ...

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    3. Measurement of Choroid Thickness Using Optical Coherence Tomography to Monitor Intracranial Pressure in an Idiopathic Cranial Hypertension Model

      Measurement of Choroid Thickness Using Optical Coherence Tomography to Monitor Intracranial Pressure in an Idiopathic Cranial Hypertension Model

      Background: Idiopathic intracranial hypertension (IIH) is a condition with increased intracranial pressure (ICP) without mass lesion or a known etiology with normal cerebrospinal fluid (CSF) composition. With optical coherence tomography (OCT), which is a noninvasive imaging technique, cross-sectional scans of the retina, choroid, and optic nerve head can be obtained with a resolution that is close to histological resolution. Aim: The study aimed to evaluate the efficacy of OCT in providing practical and sensitive measurements to follow-up patients with IIH. Materials and Methods: This retrospective study included 22 patients with IIH and 22 healthy controls. OCT was used to measure ...

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    4. Determination of retinal nerve fibre layer (RNFL ) and ganglion cell/inner plexiform layers progression rates using two optical coherence tomography systems – the PROGRESSA study

      Determination of retinal nerve fibre layer (RNFL ) and ganglion cell/inner plexiform layers progression rates using two optical coherence tomography systems – the PROGRESSA study

      Importance Glaucoma progression rates may differ depending on the retinal structural parameters measured and between devices. Background To compare retinal nerve fibre layer (RNFL) and ganglion cell/inner plexiform layers (GCL/IPL) progression rates using two spectral‐domain optical coherence tomography (OCT) systems. Design Prospective, university hospital setting. Participants Cross‐sectional study: 100 eyes from 53 glaucoma suspects and early manifest glaucoma cases. Longitudinal study: subset of 61 eyes from 33 participants. Methods Same day optic nerve and macular images were acquired using Cirrus and Spectralis systems from which RNFL and GCL/IPL thicknesses were calculated. Longitudinal analysis of RNFL ...

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    5. Agreement Between Two Optical Biometers Based on Large Coherence Length SS-OCT and Scheimpflug Imaging/Partial Coherence Interferometry

      Agreement Between Two Optical Biometers Based on Large Coherence Length SS-OCT and Scheimpflug Imaging/Partial Coherence Interferometry

      PURPOSE: To evaluate the agreement between measurements obtained with a new optical biometer (Argos; Movu Inc) using large coherence length swept-source optical coherence tomography (SS-OCT) and those obtained with an optical biometer with a rotating Scheimpflug camera, combined with partial coherence interferometry (PCI) (Pentacam AXL; Oculus Optikgeräte GmbH) in adults. METHODS: The following measurements were examined and evaluated: axial length, central corneal thickness (CCT), anterior chamber depth (ACD), mean keratometry, J 0 and J 45 vectors, and corneal diameter. Measurements with the two biometers were conducted in triplicate per instrument in a random order by the same examiner. Paired ...

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      Mentions: Giacomo Savini Movu
    6. Utility of optical coherence tomography in the diagnosis and management of optic neuropathy in patients with fibrous dysplasia

      Utility of optical coherence tomography in the diagnosis and management of optic neuropathy in patients with fibrous dysplasia

      Optic neuropathy (ON) is a highly disabling complication of fibrous dysplasia (FD). The optimal test for identifying and monitoring ON in FD is unknown. Optical coherence tomography (OCT) is an imaging modality that detects retinal nerve fiber layer (RNFL) thinning, a sign of optic nerve atrophy. The purpose of this study was to 1) assess the ability of OCT RNFL thickness measurements to identify ON in FD, 2) compare the performance of RNFL thickness to computed tomography measurements, and 3) examine changes in RNFL thickness over to assess disease progression. A retrospective cohort study was performed to assess subjects (N ...

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    7. Topographic analysis of retinal and choroidal microvasculature according to diabetic retinopathy severity using optical coherence tomography angiography

      Topographic analysis of retinal and choroidal microvasculature according to diabetic retinopathy severity using optical coherence tomography angiography

      Purpose To investigate the topographic changes in the retinal capillary plexus and the choriocapillaris according to the severity of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods Subjects were recruited and classified into one of the following four groups: normal controls ( n = 52), diabetes without DR ( n = 49), non-proliferative DR ( n = 51) and proliferative DR ( n = 38). Using OCTA, the superficial capillary plexus (SCP), deep capillary plexus (DCP) and the choriocapillaris vessel densities were measured and compared in different macular areas: the fovea (1-mm diameter circular area), parafovea (1–3-mm diameter ring) and perifovea (3–6-mm ring). Results ...

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    8. Comparison Of Corneal Measurements In Normal And Keratoconus Eyes Using Anterior Segment Optical Coherence Tomography And Pentacam Hr Topographer

      Comparison Of Corneal Measurements In Normal And Keratoconus Eyes Using Anterior Segment Optical Coherence Tomography And Pentacam Hr Topographer

      The purpose of current study is to provide a comprehensive comparison of the reliability of corneal topographic measurements between Optovue AS- OCT and a combined Scheimpflug imaging using Wavelight Oculyzer Pentacam HR in normal and keratoconus eyes.

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    9. Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol

      Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol

      Introduction Intracranial hypertension (ICH) in children can have deleterious effects on the brain and vision. It is notoriously difficult to estimate intracranial pressure (ICP) in children and existing methods deliver suboptimal diagnostic accuracy to be used as screening tools. Optical coherence tomography (OCT) may represent a valuable, non-invasive surrogate measure of ICP, as has been demonstrated in a number of associated conditions affecting adults. More recently, OCT has been employed within the paediatric age group. However, the role of OCT in detecting ICH in children has not been rigorously assessed in a systematic review for all relevant conditions. Here, we ...

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    10. Optical Coherence Tomography Angiography for Mapping Cerebral Microvasculature Based on Normalized Differentiation Analysis

      Optical Coherence Tomography Angiography for Mapping Cerebral Microvasculature Based on Normalized Differentiation Analysis

      Optical coherence tomography angiography (OCTA) is a label‐free, noninvasive biomedical imaging modality for mapping microvascular networks and quantifying blood flow velocities in vivo . Simple computation and fast processing are critical for the OCTA in some applications. Herein, we report on a normalized differentiation method for mapping cerebral microvasculature with the advantages of simple analysis and high image quality, benefitting from computation of differentiation and characteristics of normalization. Normalized differentiation values are validated to have a nearly linear relationship with flow velocities in a range using a flow phantom. The measurements in a rat cerebral cortex show that the OCTA ...

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    11. Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function

      Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function

      A method for numerical estimation and correction of aberrations of the eye in fundus imaging with optical coherence tomography (OCT) is presented. Aberrations are determined statistically by using the estimate based on likelihood function maximization. The method can be considered as an extension of the phase gradient autofocusing algorithm in synthetic aperture radar imaging to 2D optical aberration correction. The efficacy of the proposed method has been demonstrated in OCT fundus imaging with 6λ aberrations. After correction, single photoreceptors were resolved. It is also shown that wavefront distortions with high spatial frequencies can be determined and corrected.

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    12. Clinical and Optical Coherence Tomography Angiographic Features in Patients with Postcataract Stenotrophomonas maltophilia Endophthalmitis

      Clinical and Optical Coherence Tomography Angiographic Features in Patients with Postcataract Stenotrophomonas maltophilia Endophthalmitis

      Purpose . To report the clinical presentations and optical coherence tomography (OCT) angiographic features of patients with postcataract surgery endophthalmitis due to Stenotrophomonas maltophilia. Methods . A retrospective observational study of 4 patients who developed S. maltophilia endophthalmitis after cataract surgery. Pars plana vitrectomy (PPV) was performed to control the infection. Patients were followed up for six months. Complete ophthalmological examination results were collected before and after PPV. Results . Patients’ response to PPV therapy was excellent and the infection was cured in all cases. OCTA showed that, at the one-month follow-up, the vascular density (VD) and perfusion density (PD) in the superficial ...

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    13. Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

      Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

      We read with great interest the correspondence in Lancet by Marinho et al. [ 1 ] describing purported retinal manifestations of coronavirus disease (COVID-19). While there is great interest to understand potential ocular complications of COVID-19 during this pandemic, we have some concerns regarding the interpretation of the fundus and optical coherence tomography (OCT) findings. Marinho et al. examined 12 COVID-19 patients (all confirmed by PCR or antibody testing) with typical systemic disease but no visual symptoms. The reported cohort was relatively young (25–69 years; no mean or median provided) without severe systemic disease, although 2 were hospitalized. Eleven of the ...

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    14. Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis

      Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis

      ptical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). To this end, we obtained OCT scans of unilateral eyes from 33 T2DM patients without diabetic retinopathy and 40 healthy controls. The patients were categorized according to ...

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    15. A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma

      A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma

      Purpose To compare retinal nerve fiber layer thickness (RNFLT) and Bruch’s membrane opening (BMO) minimum rim width (MRW) measured by spectral-domain (SD) OCT for diagnosing glaucoma in those suspected of having the disease. Design Observational cohort study. Participants One hundred thirteen eyes from 81 patients suspected of having glaucoma based on optic nerve appearance. Methods Participants were imaged using SD OCT, and RNFLT and BMO MRW were measured. All participants showed normal visual fields at the time of imaging but were considered suspects based on the appearance of the optic disc during clinical examination. Eyes were classified as glaucomatous ...

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    16. Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study

      Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study

      Purpose To document with spectral-domain optical coherence tomography the structural stabilization of the fovea and the sealing of outer macular defects by Müller cells. Methods A retrospective case series of 45 eyes of 34 patients is described. Results In cases of a cystic disruption of the foveola as in macular telangiectasia type 2 and vitreomacular traction, the Müller cell cone provides the structural stability of the fovea. In cases of a detachment or disruption of the Müller cell cone, e.g., in foveal pseudocysts, outer lamellar holes, and degenerative and tractional lamellar holes, Müller cells of ...

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    17. Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study

      Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study

      Background Adrenoleukodystrophy (ALD) encompasses different neurological phenotypes, ranging from the most severe cerebral forms (C-ALD) to the less severe adrenomyeloneuropathy (AMN). As visual system can be varyingly involved, we aimed at exploring whether optical coherence tomography (OCT) may detect retinal abnormalities and their longitudinal changes in adult ALD patients. Methods In this cross-sectional and longitudinal study, we measured the thicknesses of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell complex (mGCC), and segmented inner and outer macula at baseline and their changes over time in 11 symptomatic adult ALD males and 10 age- and sex-matched healthy controls. Statistical analyses ...

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    18. The Effect of Anti-Tubercular Drugs on Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography

      The Effect of Anti-Tubercular Drugs on Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography

      Purpose : To study the effect of anti-tubercular drugs on retinal nerve fiber layer (RNFL) thickness using optical coherence tomography. Methods : The study was done in thirty patients newly diagnosed with pulmonary tuberculosis which were given anti-tubercular treatment (isoniazid, rifampicin, ethambutol and pyrazinamide ) at DOTS centre of K. N. TB and Chest hospital (Dr. S.N M C.) Jodhpur. Visual function tests (visual acuity, contrast sensitivity, color vision) and OCT assessment of RNFL done before initiation of treatment and after two month of treatment. Results : After two months, RNFL thinning was present in 3 eyes out of total 60 eyes in ...

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    19. A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review

      A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review

      Purpose: To evaluate the characteristics of macular retinal and subfoveal choroidal changes in patients already on taxane-based therapy by the help of spectral domain optical coherence tomograpy (SD-OCT) and determine the incidence of taxane- related cystoid macular edema (CME). Materials and Methods: In this cross-sectional case-control study, 202 patients who received taxane-based therapy due to treatment of various cancer and age and sex-matched 200 healthy control subjects were examined. Only patients who received at least 4 cycles of taxane-based therapy were taken into consideration for the taxane group. Taxane-based therapy was further divided into two subgroups; paclitaxel group (149 patients ...

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    20. OCT angiography improves views of retina blood flow

      OCT angiography improves views of retina blood flow

      Projects from Boston and Portland could help translation of OCTA into clinics. Retina blood flow: vital for diagnosis Optical coherence tomography angiography (OCTA) is a promising technique for imaging of blood vessels, in which sequential OCT scans of the same tissue cross-section reveal the sites of blood flow within those tissues, and can allow the blood oxygen content to be calculated. Examination of the retina is one promising application area for OCTA, thanks partly to the widespread adoption of conventional OCT within ophthalmology and its established place in clinical workflows. Two recent projects have published findings that could assist the ...

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    21. Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning

      Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning

      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT without using wavefront sensors. We demonstrate here unprecedented real-time OCT segmentation of eight retinal layer boundaries achieved by 3 levels of optimization: 1) a modified, low complexity, neural network structure ...

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    22. Oregon Health and Sciences University Receives a 2020 NIH Grant for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity

      Oregon Health and Sciences University Receives a 2020 NIH Grant  for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity

      Oregon Health and Sciences University Receives a 2020 NIH Grant for $341,800 for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity. The principal investigator is Yifan Jian. Below is a summary of the proposed work. The long-term goal of this project is to determine whether optical coherence tomography (OCT) and OCT angiography (OCTA) might lead more accurate and objective diagnosis, earlier intervention, and improved outcomes in retinopathy of prematurity (ROP). International consensus and National Institute of Health (NIH) funded clinical trials over the last 30 years have defined the phenotypic classifications, natural history, prognosis, and management ...

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    23. Lumedica Incorporated Receives a 2020 NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Incorporated Receives a 2020 NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Incorporated Receives a 2020 NIH Grant for $499,919 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system suitable for diagnostic retinal imaging at the point of care. The target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systems. By breaking the $15,000 system barrier we ...

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