1. Articles in category: Ophthalmology

    25-48 of 11881 « 1 2 3 4 5 ... 493 494 495 »
    1. Classification of diabetes-related retinal diseases using a deep learning approach in optical coherence tomography

      Classification of diabetes-related retinal diseases using a deep learning approach in optical coherence tomography

      Background and objectives: Spectral Domain Optical Coherence Tomography (SD-OCT) is a volumetric imaging technique that allows measuring patterns between layers such as small amounts of fluid. Since 2012, automatic medical image analysis performance has steadily increased through the use of deep learning models that automatically learn relevant features for specific tasks, instead of designing visual features manually. Nevertheless, providing insights and interpretation of the predictions made by the model is still a challenge. This paper describes a deep learning model able to detect medically interpretable information in relevant images from a volume to classify diabetes-related retinal diseases. Methods: This article ...

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    2. Optical Coherence Tomography Assessment of Risk Factors for Visual Acuity Decline after Trabeculectomy in Patients with Advanced Open-angle Glaucoma

      Optical Coherence Tomography Assessment of Risk Factors for Visual Acuity Decline after Trabeculectomy in Patients with Advanced Open-angle Glaucoma

      Précis: Thinning of the macular retinal nerve fiber layer and ganglion cell complex in the papillomacular bundle area contributed significantly to visual acuity decline in advanced glaucoma patients after trabeculectomy . Purpose: To identify structural parameters that could predict visual acuity (VA) decline after trabeculectomy in patients with advanced open-angle glaucoma. Patients and Methods: Retrospective review of 74 eyes of 74 patients with advanced glaucoma (defined as mean deviation (MD) −12▒dB or worse) and best-corrected VA (BCVA) of ≥40/200. All patients underwent trabeculectomy between 2013 and 2016. Measurements included intraocular pressure, BCVA, visual field parameters and optical coherence ...

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    3. Is optical coherence tomography angiography helpful in the differential diagnosis of choroidal nevus versus melanoma?

      Is optical coherence tomography angiography helpful in the differential diagnosis of choroidal nevus versus melanoma?

      Purpose: To describe the imaging features of choroidal nevus and melanoma using optical coherence tomography angiography, and evaluate the ability of this technique to establish the differential diagnosis based on the display of the tumor’s intrinsic vasculature. Methods: Comparative analysis of optical coherence tomography angiography findings in consecutive patients diagnosed with choroidal nevus or choroidal melanoma following a complete ophthalmic evaluation, including best-corrected visual acuity and several imaging studies: color fundus photography, B-scan ultrasound, spectral-domain optical coherence tomography, and optical coherence tomography angiography. Optical coherence tomography angiography was used to investigate qualitative differences in the tumor vasculature. Results: Thirty-six ...

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    4. Flow Density in Optical Coherence Tomography Angiography is Useful for Retinopathy Diagnosis in Diabetic Patients

      Flow Density in Optical Coherence Tomography Angiography is Useful for Retinopathy Diagnosis in Diabetic Patients

      Our study evaluated the diagnostic capability of flow density (FD) in OCT angiography (OCTA) for diabetic retinopathy (DR) detection in diabetic patients. We studied 93 eyes of 68 diabetic patients who underwent OCTA (36 and 57 eyes without and with DR, respectively). Retinal capillary FD of a 2.6 × 2.6 mm 2 area and four divided areas at the superficial (SCP) and deep capillary plexus (DCP) were measured. Predictions were evaluated using the area under the receiver operating characteristic curve (AUC). The diagnostic capabilities of the FDs in discriminating between eyes without DR and eyes with total or early ...

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    5. The use of high resolution anterior segment optical coherence tomography for the characterization of conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia

      The use of high resolution anterior segment optical coherence tomography for the characterization of conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia

      Background Conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia (BRLH) are conditions that often have a similar appearance on the ocular surface. The use of high resolution anterior segment optical coherence tomography (HR-OCT) enables clinicians to evaluate distinctive differences in tissue morphology and cellular patterns in various ocular surface conditions. In this study, we characterize the morphological differences seen in conjunctival lymphoma, conjunctival amyloidosis and BRLH on HR-OCT imaging. Methods A retrospective chart review was performed of patients with biopsy proven conjunctival lymphoma, conjunctival amyloidosis and BRLH between 2012 and 2019 at the Bascom Palmer Eye Institute. Patients were ...

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    6. Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters

      Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters

      Purpose To test the hypothesis that baseline optical coherence tomography (OCT) measures predict visual field (VF) progression in a cohort of patients with suspected or established glaucoma and compare their performance to semiquantitative optic disc measures. Design Observational cohort study. Methods Setting: Academic institution. Study Population One-hundred seventy-one eyes of 95 patients with good-quality baseline retinal nerve fiber layer (RNFL) and macular OCT images and disc photographs with >2 years of follow-up and ≥5 VFs. Observation Procedures Baseline macular and RNFL OCT measures and cup-to-disc ratio and disc damage likelihood score. Main Outcome Measures Prediction of glaucomatous visual field deterioration ...

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    7. Could optical coherence tomography add to the history of the pituitary incidentaloma?

      Could optical coherence tomography add to the history of the pituitary incidentaloma?

      Editor, While first described in the medical history as an incidental finding on autopsies or now abandoned diagnostic techniques like roentgenographic cephalometry, the pituitary incidentaloma as a clinical entity unfolded with the introduction of contemporary medical imaging like computer tomography (CT) and magnetic resonance imaging (MRI) (Nanda et al. 1967 ; Parent et al. 1982 ; Molitch & Russell 1990 ). Many pituitary tumours remain small and clinically silent. Nevertheless, the diagnosis of a pituitary incidentaloma necessitates evaluation for endocrine dysfunction or mass effect requiring treatment; the risk of serendipitous findings without any medical benefit to the patient remains an important dilemma of modern ...

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    8. Multiclass segmentation as multitask learning for drusen segmentation in retinal optical coherence tomography

      Multiclass segmentation as multitask learning for drusen segmentation in retinal optical coherence tomography

      Automated drusen segmentation in retinal optical coherence tomography (OCT) scans is relevant for understanding age-related macular degeneration (AMD) risk and progression. This task is usually performed by segmenting the top/bottom anatomical interfaces that define drusen, the outer boundary of the retinal pigment epithelium (OBRPE) and the Bruch's membrane (BM), respectively. In this paper we propose a novel multi-decoder architecture that tackles drusen segmentation as a multitask problem. Instead of training a multiclass model for OBRPE/BM segmentation, we use one decoder per target class and an extra one aiming for the area between the layers. We also introduce ...

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    9. The role of Optical Coherence Tomography in Parkinsonism: A critical review

      The role of Optical Coherence Tomography in Parkinsonism: A critical review

      Optical coherence tomography (OCT) has been evaluated as a tool to assess retinal changes in various neurodegenerative disorders. Parkinson's disease (PD), is a neurodegenerative disorder wherein dopaminergic deficiency results in some of the symptoms. As retina also has high concentration of dopamine, it would be of interest for both the clinician as well as the basic scientist to know if there is a correlation between the clinical features and the retinal changes. The objective of this review is to critically evaluate the literature and study the utility of OCT as a tool to evaluate retinal changes in PD .

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    10. Two thousand optometrists geared up for OCT at Specsavers

      Two thousand optometrists geared up for OCT at Specsavers

      More than 2000 optometrists at Specsavers have completed an extensive programme of Optical Coherence Tomography (OCT) training, ahead of the installation of the hospital-grade technology in their stores. The milestone has been reached almost half way through the rollout across the UK and Ireland of OCT, which is now in use in 400 stores. Richard Davies of the Bath store was the 2000 th optometrist to complete the set of seven online modules, which cover essentials of OCT, OCT in glaucoma, medical retina and anterior segment, and prudent referrals. Presenting a £100 voucher to Richard in store this week, Paul ...

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    11. Post-Doctoral Researcher Opening at Department of Physics, University of Coimbra, Portugal

      Post-Doctoral Researcher Opening at Department of Physics, University of Coimbra, Portugal

      We opened a tender for selecting a Post-Doctoral Researcher with a contract for an open-ended period of time. We are looking for someone with a Doctoral degree in Biomedical Engineering, Physics Engineering, Physics, Electrotechnical Engineering or a closely related area, knowledge in optoelectronic instrumentation, photonics, optics and electronics and knowledge in programming. The position concerns the ElastoOCT project - Optical Coherence Elastography for imaging retina mechanical properties – and is available at the University of Coimbra, Portugal. The aim of the project is to develop and build an optical coherence elastography system for retinal imaging, with ultrasound excitation and measurement of induced ...

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    12. The Bruno Lumbroso Lecture at the 7th International Congress on OCT Angiography, Rome, December 13 and 14, 2019

      The Bruno Lumbroso Lecture at the 7th International Congress on OCT Angiography, Rome, December 13 and 14, 2019

      Dear Colleagues, As you know, the International Congress on OCT Angiography, En Face OCT and Advances in OCT that Professor Bruno Lumbroso initiated few years ago will be in its 7th Year this December 2019 in Rome. Certainly, this global Congress has become one of the most successful, most-attended, and most educational meetings in the field of retinal imaging. Every December during the past six years, more than 1,000 of us have enjoyed spending few days in Rome learning the latest advances in retinal imaging, from OCT to OCTA to adaptive optics to microperimetry, among others, and meeting new ...

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    13. New imaging systems in diabetic retinopathy

      New imaging systems in diabetic retinopathy

      Various imaging modalities are of significant utility in the screening, grading, treatment, and follow-up of the different stages of diabetic retinopathy (DR) and diabetic macular edema. Color stereographic photography, fluorescein angiography, and optical coherence tomography (OCT) have been the gold standard for DR imaging for years. Besides these tools, newer technologies are gaining validation and popularity, such as fundus autofluorescence and OCT angiography. Furthermore, widefield retinography and ultra-widefield retinography have been introduced for a more comprehensive evaluation of the medium-far and very-far retinal peripheries, which is crucial for the assessment of the diverse manifestations of the disease. The aim of ...

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    14. Retinal texture biomarkers may help to discriminate between Alzheimer’s, Parkinson’s, and healthy controls

      Retinal texture biomarkers may help to discriminate between Alzheimer’s, Parkinson’s, and healthy controls

      A top priority in biomarker development for Alzheimer’s disease (AD) and Parkinson’s disease (PD) is the focus on early diagnosis, where the use of the retina is a promising avenue of research. We computed fundus images from optical coherence tomography (OCT) data and analysed the structural arrangement of the retinal tissue using texture metrics. We built clinical class classification models to distinguish between healthy controls (HC), AD, and PD, using machine learning (support vector machines). Median sensitivity is 88.7%, 79.5% and 77.8%, for HC, AD, and PD eyes, respectively. When the same subject has the ...

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    15. Optical Coherence Tomography Angiography for Diagnosis of Choroidal Neovascularization in Chronic Central Serous Chorioretinopathy after Photodynamic Therapy

      Optical Coherence Tomography Angiography for Diagnosis of Choroidal Neovascularization in Chronic Central Serous Chorioretinopathy after Photodynamic Therapy

      The authors evaluated the proportion of choroidal neovascularization (CNV) detected by spectral-domain optical coherence tomography angiography (OCTA) in eyes with chronic central serous chorioretinopathy (CSC) (more than 3 months) with previous treatment via half-dose photodynamic therapy (PDT). All patients were followed up with at least twelve months. Macular angiograms were obtained using spectral-domain OCT (SD-OCT, RTVue XR; Optovue). CNV was defined as flow in the outer retinal slab between the outer plexiform layer and Bruch’s membrane. Clinical characteristics were compared between CNV and non-CNV groups. Seventy eyes of 61 patients (51 male and 10 female) were included. The average ...

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      Mentions: Optovue
    16. Two-Year Risk of Exudation in Eyes with Non-Exudative AMD and Subclinical Neovascularization Detected with Swept Source OCT Angiography

      Two-Year Risk of Exudation in Eyes with Non-Exudative AMD and Subclinical Neovascularization Detected with Swept Source OCT Angiography

      Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to study the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with unilateral non-exudative age-related macular degeneration (AMD). Design Prospective cohort study. Methods Patients were imaged using 3x3 mm and 6x6 mm SS-OCTA scan patterns. MNV was detected using the outer retina to choriocapillaris en face slab. Prevalence and incidence of subclinical MNV, Kaplan-Meier cumulative estimates for the overall risk of exudation, and the association between neovascular lesion size and the risk of exudation were assessed through 2 years. Results From August 2014 through March 2018 ...

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    17. Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children

      Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children

      Purpose Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) can be used with sedation in children not amenable to traditional imaging. Purpose: to report GCC and RNFL measurements in normal children using HH-OCT. Design Prospective observational study of normal children ≤ 5-years of age. Methods Healthy, full-term children ≤5 years-old undergoing sedation or anesthesia were enrolled. Exclusion criteria: prematurity, pre-existing neurologic, genetic, metabolic or intraocular pathology. Demographic data, axial length (Master-Vu Sonomed Escalon, NY ...

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    18. Carl Zeiss Meditec expands leadership position in treating glaucoma by investing in MicroOptx, Inc.

      Carl Zeiss Meditec expands leadership position in treating glaucoma by investing in MicroOptx, Inc.

      Today, Carl Zeiss Meditec announced that it has become a shareholder of MicroOptx Inc., headquartered in Minneapolis, MN. MicroOptx is a privately held company focused on innovative minimally invasive glaucoma surgery (MIGS) devices for surgical treatment of glaucoma. Their surgical technology is designed to provide effective reduction of intraocular pressure (IOP) with a simple surgical procedure. ZEISS supports breakthrough surgical treatments for glaucoma and believes MicroOptx’s MIGS solution will complement our leading portfolio of equipment and consumables in ophthalmic surgery. “The investment in MicroOptx will give ZEISS an early position in this new technology designed to increase MIGS adoption ...

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    19. Optical coherence tomography measurements of the optic nerve head and retina in newly dia­gnosed idiopathic intracranial hypertension without loss of vision

      Optical coherence tomography measurements of the optic nerve head and retina in newly dia­gnosed idiopathic intracranial hypertension without loss of vision

      Aim: Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure (ICP), usually in young, obese women with no circulatory pathology. We investigated the relationship between optical coherence tomography (OCT) measurements and cerebrospinal fluid (CSF) opening pressure in newly dia­gnosed IIH patients who have not been treated yet . Material and methods: The study included 19 individuals dia­gnosed with IIH and 22 healthy individuals in the control group. We measured the retinal nerve fibre layer (RNFL), fovea (F) and ganglion cell complex (GCC) thickness as well as the optic nerve  head parameters in both groups . Results: The mean RNFL ...

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    20. Evaluation of choroidal changes in adolescent idiopathic scoliosis using enhanced depth imaging optical coherence tomography

      Evaluation of choroidal changes in adolescent idiopathic scoliosis using enhanced depth imaging optical coherence tomography

      Background We aimed to evaluate the choroidal thickness (CT) in patients with adolescent idiopathic scoliosis (AIS) using enhanced depth imaging optical coherence tomography (EDI‐OCT). Methods In this cross‐sectional, observational comparative study, 56 eyes of 56 patients with AIS and 56 eyes of 56 age‐ and sex‐matched healthy subjects were included. All participants underwent complete ophthalmologic examination and CT measurements at the fovea and at 750 μm intervals from the fovea to 1,500 μm in the nasal and temporal site obtained by spectral domain EDI‐OCT. Results The mean subfoveal CT was lower in the AIS patients ...

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    21. Retinal And Choroidal Optical Coherence Tomography Findings Of Carotid Cavernous Fistula

      Retinal And Choroidal Optical Coherence Tomography Findings Of Carotid Cavernous Fistula

      PURPOSE To define the retinal and choroidal imaging findings of carotid cavernous fistula (CCF) including central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI) parameters and tortuosity indexes (TI) as compared to a control group (CG). DESIGN Cross-sectional study MATERIALS AND METHODS The spectral domain enhanced-depth imaging optical coherence tomography (SD-EDI-OCT) images of 19 eyes of 19 consecutive patients with angiographically proven CCF and 19 eyes of 19 age- and sex- matched healthy control subjects were included. The patient group was divided according to CCF venous drainage pattern as anterior (A-CCF: draining into ophthalmic veins) and posterior ...

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    22. Differentiating veins from arteries on optical coherence tomography angiography by identifying deep capillary plexus vortices

      Differentiating veins from arteries on optical coherence tomography angiography by identifying deep capillary plexus vortices

      Purpose To introduce a simple method for differentiating retinal veins from arteries on optical coherence tomography angiography (OCTA). Design Cross-sectional pilot study. Methods Four default en face slabs including color depth encoded, greyscale full-thickness retina, superficial plexus, and deep capillary plexus (DCP) from 9 3x3 mm and 9 6x6 mm OCTA scans were exported and aligned. Nine ophthalmologists with minimum OCTA experience from 2 eye institutions were instructed to classify labeled vessels as arteries or veins in 3 stages. Classification was performed based on graders’ own assessment at Stage 1. Graders were taught that a capillary-free zone was an anatomic ...

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      Mentions: K. Bailey Freund
    23. Supervised Machine Learning Based Multi-Task Artificial Intelligence Classification of Retinopathies

      Supervised Machine Learning Based Multi-Task Artificial Intelligence Classification of Retinopathies

      Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical coherence tomography angiography (OCTA) imaging provides excellent capability to identify subtle vascular distortions, which are useful for classifying retinovascular diseases. However, application of AI for differentiation and classification of multiple eye diseases is not yet established. In this study, we demonstrate supervised machine learning based multi-task OCTA classification. We sought 1) to differentiate normal from diseased ocular conditions, 2) to ...

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      Mentions: Xincheng Yao
    24. Morphologic and functional outcomes of different optical coherence tomography patterns of myopic foveoschisis after vitrectomy and inner limiting membrane peeling

      Morphologic and functional outcomes of different optical coherence tomography patterns of myopic foveoschisis after vitrectomy and inner limiting membrane peeling

      Objective To evaluate the morphologic and functional outcomes of different optical coherence tomography (OCT) patterns of myopic foveoschisis after vitrectomy with Inner Limiting Membrane (ILM) peeling. Methods In this prospective non-randomised study, 62 consecutive eyes with Myopic Foveoschisis were categorised into three groups according to OCT pattern: retinoschisis type (Rt) Group (23/62), foveal detachment type (FDt) Group (20/62) and macular hole type (MHt) Group (19/62). All patients underwent 25-Gauge vitrectomy and ILM peeling. Air or gas tamponade was used. All patients were observed at month 1, 2, 4 and 6 after surgery. Main outcomes measures: surgical success ...

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