1. Articles in category: Ophthalmology

    25-48 of 11376 « 1 2 3 4 5 ... 472 473 474 »
    1. Epiretinal neovascularization- A novel optical coherence tomography angiography finding in Macular Telangiectasia type 2

      Epiretinal neovascularization- A novel optical coherence tomography angiography finding in Macular Telangiectasia type 2

      Objective To report a novel finding of EpiRetinal Neovascularization (ERN) in cases of macular telangiectasia type 2 (MacTel) and describe its clinical and multimodal imaging features. Design Retrospective chart review Subjects/ participants- Patients attending the retina clinic from January 2017 to April 2018. Those diagnosed as MacTel by clinical and imaging findings were included. Methods Best corrected visual acuity (BCVA) in the logarithm of minimal angle of resolution (log Mar), anterior segment examination, slit lamp biomicroscopy, fundus photography, spectral domain- optical coherence tomography (SD-OCT), autofluorescence (AF) imaging, fundus fluorescein angiography (FFA) and optical coherence tomography angiography (OCTA) were done in ...

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    2. Intraoperative optical coherence tomography of a dislocated intraocular lens

      Intraoperative optical coherence tomography of a dislocated intraocular lens

      An 88-year-old female with pseudoexfoliation syndrome presented with sudden vision loss and was found to have a dislocated one piece intraocular lens (IOL) that was resting on the retina. She underwent 23-gauge pars plana vitrectomy, IOL explantation, and anterior chamber IOL insertion. Intraoperative optical coherence tomography (EnFocus iOCT; Leica, Wetzlar, Germany) was used to assess the position and vault of the IOL on the retinal surface [Figure 1] a. Utilization of iOCT enabled the surgeon to safely grasp the IOL with forceps in the location with the greatest vault in order to minimize any potential trauma to the retina [Figure ...

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    3. The Bull’s Eye Pattern of the Tear Film in Humans during Visual Fixation on En-Face Optical Coherence Tomography

      The Bull’s Eye Pattern of the Tear Film in Humans during Visual Fixation on En-Face Optical Coherence Tomography

      The aim of the study was to define and characterize the optical behavior of the tear film during visual fixation in humans on en-face optical coherence tomography (OCT). We included 20 healthy participants, 60% female, aged from 25 to 42 years (33.05 ± 4.97 [mean ± SD]) and ten patients with severe dry eye, 50% female, aged from 26 to 42 years (33.7 ± 5.31). To perform high-resolution tear film imaging, participants were asked to gaze at the internal fixation point in the spectral-domain anterior segment OCT device, and meanwhile scanning session was executed at the following time-points after ...

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    4. Macular vascular density at the superficial capillary plexus using the optical coherence tomography angiography

      Macular vascular density at the superficial capillary plexus using the optical coherence tomography angiography

      Purpose: The aim of this study was to assess the effects of age, gender, axial length and retinal thickness on the vascular density in a normal population using the Optovue optical coherence tomography angiography (OCT-A). Methods: A total of 209 eyes of 209 healthy subjects were scanned using the OCT-A on an outpatient basis. Patients were 20–75 years of age. The built-in software covered a 3×3 mm circle centered at the macula. The circle was divided into five sectors: a 1 mm central foveal circle and an upper, lower, nasal and temporal sector each spanning 1–3 mm ...

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      Mentions: Optovue
    5. Vessel Density in nAMD After Longterm Anti-VEGF Treatment Compared to Recently Started Anti-VEGF Treatment

      Vessel Density in nAMD After Longterm Anti-VEGF Treatment Compared to Recently Started Anti-VEGF Treatment

      Neovascular age-related macular degeneration (nAMD) is characterized by the abnormal growth of blood vessels from the choroid into the subretinal space which leads to sub- and intraretinal fluid accumulation, hemorrhages and subretinal fibrosis with progressive loss of central vision. Intravitreal anti-VEGF treatment is the standard of care. Intravitreal anti-VEGF application might temporarily increase intraocular pressure due to a volume effect. It remains unclear if repeated injections might have an impact on retinal capillary perfusion. Therefore this study aims to investigate the vascular microcirculation differences between patients who received longterm intravitreal Anti-VEGF treatment and patients who recently started Anti-VEGF treatment using ...

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    6. Clinical Features of Pingueculitis Revealed by Anterior Segment Optical Coherence Tomography Findings

      Clinical Features of Pingueculitis Revealed by Anterior Segment Optical Coherence Tomography Findings

      Purpose: To investigate clinical features and treatment outcomes of pingueculitis with morphological assessments using anterior segment optical coherence tomography (AS-OCT). Methods: In this retrospective observational study, we examined 22 eyes of 22 patients with pingueculitis . All patients were treated with the same 2-week course of prednisolone acetate 1% drops four times per day. The clinical parameters evaluated were surface dimensions determined by slitlamp biomicroscopy, cross-sectional dimensions determined by AS-OCT, and symptom scores determined by patient surveys. Pretreatment and 1-month posttreatment values were compared with Wilcoxon signed-rank tests. Patients were followed up to 1 year after treatment. Results: Twenty-two eyes from ...

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    7. Impact of Cataract Surgery on Filtering Bleb Morphology Identified Via Swept-source Three-dimensional Anterior Segment Optical Coherence Tomography

      Impact of Cataract Surgery on Filtering Bleb Morphology Identified Via Swept-source Three-dimensional Anterior Segment Optical Coherence Tomography

      Purpose: To identify the cross-sectional morphological changes in successful filtering blebs after phacoemulsification using swept-source three-dimensional anterior segment optical coherence tomography (3D AS-OCT). Materials and Methods: Thirty phakic eyes of 29 patients with successful filtering blebs after primary trabeculectomy were included in this retrospective cohort study. Success was defined as intraocular pressure (IOP)≤15▒mmHg and a>20% reduction in IOP without glaucoma medication or additional glaucoma surgery after trabeculectomy . The subjects were classified into two groups according to whether they had undergone phacoemulsification or not after trabeculectomy : a phaco group and a control group. Filtering blebs were examined using ...

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    8. Bleb Morphology After Mitomycin-C Augmented Trabeculectomy – Comparison between Clinical Evaluation and Anterior Segment Optical Coherence Tomography

      Bleb Morphology After Mitomycin-C Augmented Trabeculectomy – Comparison between Clinical Evaluation and Anterior Segment Optical Coherence Tomography

      Purpose: To study the longitudinal correlation between the clinical morphological appearance of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in the early postoperative period. Methods: Thirty eyes of 30 glaucoma patients scheduled for first-time trabeculectomy with mitomycin C 0.02% were consecutively enrolled. The filtering blebs were evaluated clinically according to a grading system and with AS-OCT at day 1 and weeks 1, 2, 3, 4 and 12 following surgery. Bleb wall thickness (BWT) and bleb cavity height (BCH) were analyzed by means of horizontal and vertical AS-OCT-scans. Results: Nineteen eyes (63%) had functioning blebs without any further ...

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    9. Imaging of meibomian glands: from bench to bedside and back

      Imaging of meibomian glands: from bench to bedside and back

      In this issue of Eye, Randon et al. [ 1 ] present the interesting findings of an in vivo confocal microscopy (IVCM) cross-sectional study in which they describe different patterns of presumed meibomian glands (MGs) abnormalities and propose a new IVCM–meibomian gland dysfunction (MGD) classification. This research represents an interesting effort toward a personalized diagnostic and therapeutic approach to MGD patients. In the last years, we have seen an imaging revolution in the study of MGD. Technological evolution provided us new non- (or nearly non-) invasive tools, including infrared (IR) meibography [ 2 ], IVCM, and optical coherence tomography meibography (OCT-M) [ 3 , 4 ...

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    10. Central corneal thickness measurement using ultrasonic pachymeter, optical coherence tomography, and TMS-5 topographer

      Central corneal thickness measurement using ultrasonic pachymeter, optical coherence tomography, and TMS-5 topographer

      AIM: This study aimed to compare the central corneal thickness (CCT) measurements using Optical Coherence Tomography (OCT) and TMS-5 topographer with that taken with the gold standard digital Ultrasonic pachymeter (USP). MATERIALS AND METHODS: A total of 61 subjects (122 eyes) were prospectively and consecutively studied in a period from June 2016 to June 2017 at Sudan Eye Centre (SEC), Khartoum, Sudan. Besides the visual and refractive data, measurements of CCT were taken using OCT, TMS-5 and USP. Data analyzed using SPSS software for windows (IBM SPSS 20, IBM Corp., Armonk, NY). RESULTS: A statistically significant differences in mean CCT ...

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    11. Serial swept-source optical coherence tomography: Tale of a choroidal tuberculom

      Serial swept-source optical coherence tomography: Tale of a choroidal tuberculom

      Choroidal tuberculoma is a solitary elevated choroidal mass-like lesion regarded often characteristic of intraocular tuberculosis. Serial swept-source optical coherence tomography (SS-OCT) is a very important tool in monitoring the course of choroidal tuberculoma and allows in early detection of complications such as choroidal neovascular membrane (CNVM). We describe a 26-year-old young Indian female, who presented with a solitary choroidal mass lesion in the left eye. Based on positive Mantoux test, biopsy of cervical lymph nodes showing acid-fast bacilli and radiographic findings, a diagnosis of choroidal tuberculoma was made. Serial SS-OCT during subsequent follow-up visits up to 14 months demonstrated the ...

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    12. Optical coherence tomography angiography for the anterior segment

      Optical coherence tomography angiography for the anterior segment

      Optical coherence tomography angiography (OCTA) is a rapid and non-invasive technique for imaging vasculature in the eye. As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest, it has become a promising method for anterior segment imaging. Furthermore, OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography. However, conventional OCTA systems are typically designed and optimized for the posterior segment of the eye, and thus using OCTA for anterior segment imaging can present several difficulties and limitations. In this review, we summarized the recent developments and clinical applications ...

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    13. The findings of optical coherence tomography of retinal degeneration in relation to the morphological and electroretinographic features in RPE65−/− mice

      The findings of optical coherence tomography of retinal degeneration in relation to the morphological and electroretinographic features in RPE65−/− mice

      Purpose Mutations of the gene encoding RPE65 cause Leber congenital amaurosis (LCA) retinitis pigmentosa (RP). The optical coherence tomography (OCT) is increasingly utilized to noninvasively evaluate various types of retinal diseases, including RP. The present study was conducted to characterize the OCT findings of the RPE65 −/− mice—an animal model of LCA and RP—in relation to the morphological features based on histological and electron microscopic findings as well as electroretinography (ERG) features. Materials and methods RPE65 −/− mice were employed as a model of retinal degeneration. C57BL/6J mice were used as a wild-type control. OCT was performed on the ...

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    14. Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography

      Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography

      Background/aims Microperimetry is a technique that is increasingly used to assess visual function in age-related macular degeneration (AMD). In this study, we aimed to evaluate the relationship between retinal sensitivity measured with macular integrity assessment (MAIA) microperimetry and optical coherence tomography (OCT)-based macular morphology in AMD. Methods Prospective, cross-sectional study. All participants were imaged with colour fundus photographs used for AMD staging (Age-Related Eye Disease Study scale), spectral-domain OCT (Spectralis, Heidelberg, Germany) and swept-source OCT (Topcon, Japan). Threshold retinal sensitivity of the central 10° diameter circle was assessed with the full-threshold, 37-point protocol of the MAIA microperimetry device ...

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    15. UCLA Receives NIH Grant for Vitroretinal Surgery via Rogbotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      UCLA Receives NIH Grant for Vitroretinal Surgery via Rogbotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality

      University of California at Los Angeles Receives a 2019 NIH Grant for $439,347 for Vitroretinal Surgery via Rogbotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality. The principal investigator is Jean-Pierre Hubschman. The program began in 2019 and ends in 2024. Below is a summary of the proposed work. The aims of the present proposal are to extend our work with the Intraocular Robotic Interventional and Surgical System (IRISS) and augment it for teleoperated vitreoretinal surgery. Although novel technologies such as intraoperative optical coherence tomography (i-OCT) have been developed, vitreoretinal surgeons still lack critical information ...

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    16. OSHU Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      OSHU Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health & Science University Receives a 2019 NIH Grant for $496,687 for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the eye, including the cornea, conjunctiva, sclera, anterior chamber, iris, and crystalline lens. Anterior segment OCT is already widely used in ophthalmology. But ...

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    17. Duke University Receives NIH Grant for Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young Children

      Duke University Receives NIH Grant for Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young Children

      Duke University Receives a 2019 NIH Grant for $230,682 for Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young Children. The principal investigator is Sina Farsiu. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. Eye diseases in young children, if not detected and treated early, can lead to serious vision loss and even blindness. We have pioneered development of handheld spectral domain optical coherence tomography (HH- SDOCT) imaging systems to provide 3-D visualization of intra-retinal structures. Our previous studies based on HH-SDOCT of neonatal retina have already provided unique ...

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    18. Lightoptech Corporation Receives NIH Grant for Towards In Vivo High-Definition 3D Corneal Imaging

      Lightoptech Corporation Receives NIH Grant for Towards In Vivo High-Definition 3D Corneal Imaging

      Lightoptech Corporation Receives a 2019 NIH Grant for $225,000 for Towards In Vivo High-Definition 3D Corneal Imaging. The principal investigator is Cristina Canavesi. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The cornea, the outermost window of our visual system, is vulnerable to various types of infections and diseases. Corneal disease is one of the leading causes of visual deficiency and blindness.!There are nearly 5 million bilaterally corneal blind persons worldwide, and an estimated 23 million people affected by unilateral corneal blindness globally. In a conservative estimate, corneal diseases ...

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    19. Optical coherence tomography angiographic findings in preeclampsia – A novel longitudinal report

      Optical coherence tomography angiographic findings in preeclampsia – A novel longitudinal report

      Preeclampsia is a hypertensive disorder affecting between 2%–8% of pregnancies. Ocular complications described in preeclampsia include hypertensive retinopathyretinal vessels occlusion, hypertensive choroidopathy, serous retinal detachment and choroidal infarcts with the commonest finding being severe arteriolar spasm [1,2]. In the acute stage of the diseasesub retinal and intraretinal fluids may be demonstrated by optical coherence tomography (OCT), a light-based imaging modality with near-histologic, ultrahigh resolution.; En face OCT (special software reconstruction of OCT images) provides segmented visualization of the various retinal layerswhile OCT angiography, allows a noninvasive micro vascular assessment [3].

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    20. Methods and apparatus for reducing artifacts in OCT angiography using machine learning techniques

      Methods and apparatus for reducing artifacts in OCT angiography using machine learning techniques

      In some embodiments of the present invention, a method of reducing artifacts includes obtaining OCT/OCTA data from an OCT/OCTA imager; preprocessing OCTA/OCT volume data; extracting features from the preprocessed OCTA/OCT volume data; classifying the OCTA/OCT volume data to provide a probability determination data; determining a percentage data from the probability data determination; and reducing artifacts in response to the percentage data.

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    21. Lens anatomy parameters with intraoperative spectral-domain optical coherence tomography in cataractous eyes

      Lens anatomy parameters with intraoperative spectral-domain optical coherence tomography in cataractous eyes

      Purpose: To study correlations of crystalline lens anatomy and position parameters obtained using intraoperative spectral-domain (SD) optical coherence tomography (OCT) in cataract patients. Methods: This retrospective study evaluated biometry data from 600 eyes of 399 cataract patients (mean age: 69±8.4 years) using intraoperative anterior segment SD-OCT during femtosecond laser-assisted cataract surgery. Lens anatomy and position parameters (anterior chamber depth [ACD] – center of the anterior cornea to the anterior lens capsule, lens thickness [LT] – distance between anterior and posterior lens capsules, and lens meridian position [LMP] – distance from center of the anterior cornea to intersection of the anterior and ...

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    22. Unsupervised feature extraction of anterior chamber OCT images for ordering and classification

      Unsupervised feature extraction of anterior chamber OCT images for ordering and classification

      We propose an image processing method for ordering anterior chamber optical coherence tomography (OCT) images in a fully unsupervised manner. The method consists of three steps: Firstly we preprocess the images (filtering the noise, aligning and normalizing the resolution); secondly, a distance measure between images is computed for every pair of images; thirdly we apply a machine learning algorithm that exploits the distance measure to order the images in a two-dimensional plane. The method is applied to a large (~1000) database of anterior chamber OCT images of healthy subjects and patients with angle-closure and the resulting unsupervised ordering and classification ...

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