1. Articles in category: Ophthalmology

    25-48 of 11652 « 1 2 3 4 5 ... 484 485 486 »
    1. A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field

      A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field

      Purpose To compare the retinal area measured on a panoramic en face optical coherence tomography angiography (OCTA) image with that on an ultra-widefield fluorescein angiography (UWF FA) image. Methods Sixteen eyes (11 with branch retinal vein occlusion, 2 with central retinal vein occlusion, 1 with branch retinal artery occlusion, and 2 with hypertensive retinopathy) were included in this study. A panoramic en face OCTA image was created from five single non-panoramic en face OCTA 12 × 12-mm images. The panoramic OCTA image was superimposed on the corresponding UWF FA image after image registration; the total retinal area was measured using the ...

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    2. Enhanced depth imaging and swept-source optical coherence tomography findings in choroidal osteoma: a case report

      Enhanced depth imaging and swept-source optical coherence tomography findings in choroidal osteoma: a case report

      Purpose The aim of this study was to report the findings from enhanced depth imaging (EDI) and swept-source optical coherence tomography (OCT) in a choroidal osteoma. Methods A case study of a patient with choroidal osteoma is presented and discussed. Results A 25-year-old woman presented with an asymptomatic peripapillary mass. Fundus examination revealed a yellow–orange, well-defined geographical lesion. B‑scan ultrasonography, corroborated by fundus autofluorescence (FAF) and OCT findings, pointed to the diagnosis of choroidal osteoma. Calcified areas of the tumor were iso-autofluorescent on FAF and hyporeflective on OCT, revealing the morphological patterns of cancellous bone, including a sponge-like ...

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    3. Optical Coherence Tomography Angiography: Practical Usefulness

      Optical Coherence Tomography Angiography: Practical Usefulness

      Purpose: The purpose of this article is to highlight the practical usefulness of optical coherence tomography angiography (OCTA) in the management of a spectrum of retinal diseases and support it as a reimbursable diagnostic tool by third-party payers. Methods: Case presentations are discussed. Results: Noninvasive OCTA provides information to guide clinical decision making, prognosis, and treatment response across a wide variety of retinal disorders. Conclusions: OCTA is able to detect ischemic and neovascular processes in numerous retinal diseases and is valuable for diagnosis and treatment. OCTA is able to meet all the criteria required for reimbursement of a new diagnostic ...

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    4. Decreasing the Size of a Spectral Domain Optical Coherence Tomography System With Cascaded ...

      Decreasing the Size of a Spectral Domain Optical Coherence Tomography System With Cascaded ...

      This paper describes a proof-of-concept of a miniaturized spectral-domain optical coherence tomography system, based on photonic integrated circuit (PIC) technology. The integrated optics 512-channel spectrometer consists of cascaded arrayed waveguide gratings (AWG) with the output waveguides directly attached to a CCD detector. The spectrometer has a center wavelength of 850 nm and a spectral sampling interval of 0.22 nm. The PIC has a footprint of 2.0 × 2.7 cm 2 . The wavelength response of the cascaded AWG spectrometer is calibrated with a tunable laser. Free space OCT measurements are done with a mirror as sample. The signal-to-noise ratio ...

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    5. Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      T Purpose To investigate retinal microvascular findings detected by optical coherence tomography angiography (OCT-A) in amblyopic eyes compared with normal eyes. Methods A total of 23 amblyopic (strabismic, ametropic, anisometropic, and meridional amblyopia) and 22 normal eyes were included in this prospective observational, comparative study. All patients underwent complete ophthalmological examination and OCT-A imaging. Vessel density (VD) percentage in the superficial and deep retinal vessel plexus, foveal avascular zone (FAZ) area, flow area in the outer retina and choriocapillaris, and retinal thickness in μm in a 6.00 × 6.00 mm scan size were measured and compared between groups. Results ...

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    6. Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography

      Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography

      Purpose To find the potential relation between changes in retinal large vessels and terminal vessels using colour Doppler flow imaging (CDFI) and optical coherence tomography angiography (OCTA) and to compare the respective advantages of CDFI and OCTA in evaluating vascular changes in retinitis pigmentosa (RP) patients. Methods A prospective series of case study was conducted to enrol RP patients and age‐matched controls, who were, respectively, imaged by CDFI and OCTA. Repeatability and reproducibility of both CDFI and OCTA were performed among healthy volunteers. The central retinal artery (CRA) was detected by CDFI analysis to provide parameters of peak systolic ...

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    7. Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography in Selected Posterior Uveitides (Book Chapter)

      Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography in Selected Posterior Uveitides (Book Chapter)

      The pathogenesis of uveitis entails changes in the structural morphology of the macula, choroid, and choroidal perfusion. Documentation of these pathologic alterations is pivotal in making a proper diagnosis and in follow-up of outcomes of therapy. The newly-introduced swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (SS-OCTA) were harbingers of a whole new era of noninvasive in vivo layer-to-layer dissection of macular and choroidal structural changes in uveitis and of disease-related vascular profile patterns. This new information unraveled new aspects of the underlying pathogenetic mechanisms in different uveitides and added to our understanding of the disease process. Monitoring ...

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    8. Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

      Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

      We report a novel design and operation of a highly integrated miniature handheld OCT probe, with high-speed angiography function that can be used in clinical settings for young children and infants, providing rapid, non-invasive structural and angiographic imaging of the retina and choroid. The imaging system is operated at 200 kHz, with 3D OCT and OCTA scan time of 0.8 and 3.2 seconds, respectively, and the scanning angle on the pupil is ± 36°, covering the full perifoveal region. Operator assisting features of the direct-view iris camera and on-probe display are integrated into the hand-held probe, and the fixation ...

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    9. Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder

      Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder

      Background Volume reductions in brain structures of patients with schizophrenia spectrum disorder (SSD) have repeatedly been found in voxel-based morphometry MRI studies. Hence, an underlying neurodegenerative etiological component of SSD is currently being discussed. In recent years, the imaging method of optical coherence tomography (OCT) has shown its potential in evaluating structural changes in the retina in patients with confirmed neurodegenerative disorders, providing a window into the brain. Methods Twenty-six patients with schizophrenia or schizoaffective disorder and 23 age- and sex-matched healthy controls were examined with the Heidelberg Spectralis OCT system to derive a single-layer analysis of both retinas. The ...

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    10. Sensitivity and Specificity of Potential Diagnostic Features Detected Using Fundus Photography, Optical Coherence Tomography, and Fluorescein Angiography for Polypoidal Choroidal Vasculopathy

      Sensitivity and Specificity of Potential Diagnostic Features Detected Using Fundus Photography, Optical Coherence Tomography, and Fluorescein Angiography for Polypoidal Choroidal Vasculopathy

      Importance The use of indocyanine green angiography (ICGA) is a criterion standard for diagnosing polypoidal choroidal vasculopathy (PCV), an endemic and common cause of vision loss in Asian and African individuals that also presents in white individuals. However, the use of ICGA is expensive, invasive, and not always available at clinical centers. Therefore, knowing the value of certain features detected using fundus photography (FP), optical coherence tomography (OCT), and fluorescein angiography (FA) to diagnose PCV without ICGA could assist ophthalmologists to identify PCV when ICGA is not readily available. Objective To explore the sensitivity, specificity, and predictive accuracy of potential ...

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    11. Method and system for optically evaluating drilling proximity to the inferior alveolar nerve in situ

      Method and system for optically evaluating drilling proximity to the inferior alveolar nerve in situ

      A low coherence interferometry probe system for evaluating proximity to a tissue layer, comprising a low coherence light source for generating low coherence excitation light, an excitation optical fiber to bring the low coherence excitation light near the tissue layer and a collection optical fiber for capturing back-scattered light from the tissue layer. The probe system comprises a low coherence interferometry sub-system and a digital signal processor for evaluating a distance to the tissue layer. There is also provided a spectral absorption probe system for evaluating proximity to an artery, comprising a light source excitation light having a wavelength adapted ...

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    12. Methods and apparatus for retina blood vessel assessment with OCT angiography

      Methods and apparatus for retina blood vessel assessment with OCT angiography

      A method of processing a 3D OCT dataset is present. A method according to some embodiments of the present invention includes obtaining an OCT data from the 3D OCT dataset; obtaining an OCTA data from the 3D OCT dataset; performing segmentation for at least one boundary on the OCT data; processing the OCTA data in a region of interest to create at least one image representation by assigning a value to each pixel of each of the image representation; and displaying at least one image representation.

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    13. Monitoring Large Vessel Vasculitis With PET/MR Imaging

      Monitoring Large Vessel Vasculitis With PET/MR Imaging

      Large vessel vasculitis (LVV) causes blood vessel inflammation leading to pain, fatigue and complications such as aneurysm formation and stroke. Treatments used can have significant side-effects. Doctors find it difficult to determine when to start and stop treatment, often leading to over- or under-treatment. A new test is required to determine disease activity that will guide treatment more accurately. This study will recruit participants with active LVV from throughout Scotland in order to assess the ability of two new types of scan - positron emission tomography with magnetic resonance imaging (PET/MR) and retinal optical coherence tomography (OCT) - to determine disease ...

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    14. Optical coherence tomography in paediatric clinical practice

      Optical coherence tomography in paediatric clinical practice

      Optical coherence tomography is a non‐invasive ocular imaging technique that is frequently used in the diagnosis and monitoring of optic nerve or retinal disease. Advances in optical coherence tomography speed and image processing capability allow increased use of the modality in clinical practice, especially in younger children. This review outlines the challenges involved in imaging children, highlights the technological progress, the importance of acquiring normative data and, finally, focuses on the clinical applicability of optical coherence tomography in our paediatric population with various ocular conditions.

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    15. Hemoglobin level and macular thinning in sickle cell disease

      Hemoglobin level and macular thinning in sickle cell disease

      Purpose: To study the relationship between complete blood count (CBC) indices over time, particularly serum hemoglobin (Hb) levels, and severity of macular thinning on spectral domain optical coherence tomography (SD-OCT) in patients with sickle cell disease (SCD). Methods: This is a single-center, retrospective analysis of 141 consecutive SCD patients over a 10-year period, of which 40 patients (79 eyes) had SD-OCT imaging of the macula and 29 (58 eyes, mean age 17.5 years) were eligible for the study. Investigators reviewed electronic medical records for documentation of retinopathy stage, disease genotype, CBC values, and SD-OCT imaging. SD-OCT parameters and CBC ...

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      Mentions: Yale University
    16. Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images

      Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images

      Purpose . Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods . A retina specialist diagnosed 1,200 OCT images. The diagnoses involved normal eyes ( ) and those with wet age-related macular degeneration (AMD) ( ), diabetic retinopathy (DR) ( ), epiretinal membranes (ERMs) ( ), and another 19 diseases. Among them, 1,100 images were used for deep learning training, augmented to 59,400 by horizontal flipping, rotation, and translation. The remaining 100 images were used to evaluate the trained convolutional neural network ...

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    17. Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques

      Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques

      Purpose . To illustrate a data-driven deep learning approach to predicting the gene responsible for the inherited retinal disorder (IRD) in macular dystrophy caused by ABCA4 and RP1L1 gene aberration in comparison with retinitis pigmentosa caused by EYS gene aberration and normal subjects. Methods . Seventy-five subjects with IRD or no ocular diseases have been ascertained from the database of Japan Eye Genetics Consortium; 10 ABCA4 retinopathy, 20 RP1L1 retinopathy, 28 EYS retinopathy, and 17 normal patients/subjects. Horizontal/vertical cross-sectional scans of optical coherence tomography (SD-OCT) at the central fovea were cropped/adjusted to a resolution of 400 pixels/inch with ...

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    18. Comparison of Laser In Situ Keratomileusis Flap Morphology and Predictability by WaveLight FS200 Femtosecond Laser and Moria Microkeratome: An Anterior Segment Optical Coherence Tomography Study

      Comparison of Laser In Situ Keratomileusis Flap Morphology and Predictability by WaveLight FS200 Femtosecond Laser and Moria Microkeratome: An Anterior Segment Optical Coherence Tomography Study

      Purpose To evaluate laser in situ keratomileusis (LASIK) flap thickness predictability and morphology by femtosecond (FS) laser and microkeratome (MK) using anterior segment optical coherence tomography. Methods Fifty-two candidates for the LASIK procedure were stratified into two groups: FS laser-assisted (Allegretto FS-200) and MK flap creation (Moria 2). Flap thickness was determined at five points. The side-cut angle was measured in three directions at the margin interface. LASIK flap assessment was performed one month postoperatively by Spectralis anterior segment optical coherence tomography. Results Fifty-two patients (93 eyes) were recruited; 49 eyes were stratified to the FS group and 44 eyes ...

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    19. Assessment of neurodegeneration by optical coherence tomography and mini–mental test in Parkinson's disease

      Assessment of neurodegeneration by optical coherence tomography and mini–mental test in Parkinson's disease

      Background: Parkinson's disease is a neurodegenerative disease. Cognitive disorders and retinal degeneration may occur during the early stages of the disease. Retinal degeneration and cognitive findings can be assessed easily with optical coherence tomography and mini–mental test, respectively. Materials and Methods: Twenty-two patients who are being followed-up with Parkinson's disease and 22 healthy controls have been included in the study. The Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn–Yahr staging of the patients have been conducted at the time of admission. Retinal nerve fiber layer analysis and ganglion cell thickness (ganglion cell complexes [GCCs]) were ...

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    20. Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series

      Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series

      Objective To compare clinical characteristics of patients suffering from neovascular age-related macular degeneration (nAMD) with mature and immature choroidal neovascularisation (CNV) as assessed by optical coherence tomography angiography (OCTA). To explore the effect of total anti-vascular endothelial growth factor exposure on the occurrence of mature CNV when correcting for potential confounders. Methods and analysis In this retrospective case series, we included 40 eyes of 36 patients with nAMD with CNV assessed by OCTA at the Manchester Eye Hospital between June 2016 and June 2017. A retinal specialist masked to patient information graded CNV depicted on OCTA scans. For statistical comparisons ...

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    21. TAMOXIFEN-INDUCED CHORIORETINAL CHANGES An Optical Coherence Tomography and Optical Coherence Tomography Angiography Study

      TAMOXIFEN-INDUCED CHORIORETINAL CHANGES An Optical Coherence Tomography and Optical Coherence Tomography Angiography Study

      Purpose: To study structural chorioretinal changes in tamoxifen -treated patients. Methods: Cross-sectional case–control study comparing structural chorioretinal aspects in tamoxifen -treated patients and healthy controls. Enhanced depth spectral domain optic coherence tomography with choroidal binarization and optic coherence tomography angiography were performed. Individual retinal layer thickness and chorioretinal vascular components were compared. Subgroup analysis regarding history of chemotherapy was performed. Results: Two hundred eyes of 100 TAM-treated patients (Group 1) and 80 eyes of 40 healthy controls (Group 2) were included. Of the 200 spectral domain optic coherence tomography scans from patients, 2 showed structural changes attributable to tamoxifen ...

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    22. Progression of Diabetic Microaneurysms According to the Internal Reflectivity on Structural Optical Coherence Tomography and Visibility on Optical Coherence Tomography Angiography

      Progression of Diabetic Microaneurysms According to the Internal Reflectivity on Structural Optical Coherence Tomography and Visibility on Optical Coherence Tomography Angiography

      Purpose To investigate the progression of diabetic microaneurysms (MAs) according to the spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA) characteristics and to evaluate their influence on the retinal extracellular fluid accumulation at 1 year follow-up in patients with nonproliferative diabetic retinopathy (NPDR). Design Prospective, observational case series. Methods Fourteen patients with NPDR underwent SD-OCT and OCTA at the baseline and at 1 year follow-up. For all the selected MAs the visibility, the changes of internal reflectivity, graded as hyporeflective, moderate, or hyperreflective, and the extracellular fluid accumulation surrounding each MA on SD-OCT at 1 year were evaluated. The ...

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    23. Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

      Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

      Purpose: To report a case of ocular cystinosis diagnosed by anterior segment optical coherence tomography (AS-OCT) and histopathology. Methods: A 67-year-old man who presented with eye pain was found to have unilateral corneal crystal deposition. Ocular cystinosis was diagnosed by histopathology, AS-OCT, and lack of renal involvement of the disease. Results: AS-OCT showed hyperreflective densities in the corneal epithelium. The patient underwent superficial keratectomy given irregular astigmatism prior to cataract surgery. Electron microscopy of the corneal scrapings revealed epithelial cells with intracystoplasmic membrane-bound crystals confirming the diagnosis of cystinosis. Conclusion: To our knowledge, this is the first reported case of ...

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