1. Articles in category: Ophthalmology

    25-48 of 14575 « 1 2 3 4 5 ... 606 607 608 »
    1. Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography

      Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography

      Purpose : To investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes. Methods : In total, 39 unaffected healthy eyes of 39 subjects were examined using a PS-OCT clinical prototype. The degree of depolarization, expressed as the polarimetric entropy, was assessed in the RPE, the superficial and the total choroid layer, especially in the center, the inner, or the outer areas centered at the fovea. The values and their association with the demographic data were analyzed. Near-infrared fundus autofluorescence (NIRAF ...

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    2. A Normative Database of A-Scan Data Using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography Machine

      A Normative Database of A-Scan Data Using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography Machine

      Purpose Develop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine. Methods This study is a retrospective cross sectional analysis of macular and circumpapillary OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intraocular pressure, biomicroscopy, posterior segment examination and OCT scan. The volume and thickness of each of the nine Early Treatment Diabetic Retinopathy zones at the macula were analysed for the total retinal thickness, retinal nerve fibre layer (RNFL), ganglion cell layer ...

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    3. Non-contact, in-vivo, functional, and structural ophthalmic imaging using multimodal photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Non-contact, in-vivo, functional, and structural ophthalmic imaging using multimodal photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Early diagnosis of ocular diseases improves the understanding of pathophysiology and helps with accurate monitoring and effective treatment. Advanced multimodal ocular imaging platforms play a crucial role in the visualization of the ocular components and provide clinicians with a valuable tool for evaluating different eye diseases. Here, for the first time, we present a non-contact, multimodal photoacoustic remote sensing (PARS) microscopy and swept-source optical coherence tomography (SS-OCT) for in-vivo functional and structural imaging of the eye. The system provides complementary imaging contrasts of optical absorption and optical scattering and is used for non-contact, in-vivo imaging of the murine eye. Results ...

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    4. Asclepix Therapeutics partners with Notal Vision on Home OCT remote monitoring in DME and AMD clinical trials

      Asclepix Therapeutics partners with Notal Vision on Home OCT remote monitoring in DME and AMD clinical trials

      Notal Vision, Inc. announced today that the company will provide AsclepiX Therapeutics with Home OCT monitoring services through its Notal Vision Diagnostic Clinic to support AsclepiX’s AXT107 phase 1 clinical trial program. The exploratory application of the investigational home monitoring platform will add new valueable data points between the regulary scheduled study office visits. Study subjects with diabetic macular edema (DME) and wet age-related macular degeneration (AMD), who participate in the CONGO and SHASTA study sponsored by AsclepiX Therapeutics, will perform sequential daily self-imaging of their eyes with the user-friendly, self-operated Notal Home OCT device in their homes. The ...

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    5. OCT image processing

      OCT image processing

      An apparatus for rendering optical coherence tomography, OCT, retinal image data, acquired by an OCT scanner scanning a retina of an eye over a range of scan locations, wherein each scan location is associated with a respective coordinate in a first coordinate system, and each pixel of the rendered OCT retinal image data is associated with a respective coordinate in a second coordinate system different from the first coordinate system. The apparatus comprises a communication module arranged to receive the OCT retinal image data, and a coordinate-determining module arranged to determine values of coordinates in the second coordinate system of ...

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      Mentions: Optos
    6. Optical Coherence Tomography in Pituitary Adenomas Serves as a Predictor for Visual Functionality Postresection

      Optical Coherence Tomography in Pituitary Adenomas Serves as a Predictor for Visual Functionality Postresection

      Introduction: The current gold standard for evaluating functional impairment of pituitary tumors is Humphrey visual field (HVF) testing. However, optical coherence tomography (OCT) may serve as an alternative in predicting return of visual function in postoperative surgically resected patients diagnosed with a pituitary adenoma. Methods: After application of exclusion criteria, we identified 12 patients with pituitary adenomas that had been treated surgically at our institution from 2017 to 2019. Patient pre- and postoperative visual acuity, mean deviation, HVF features, retinal nerve fiber layer (RNFL) characteristics, retinal ganglion cell layer (RGCL) thickness, and duration of symptoms were retrospectively reviewed. Results: The ...

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    7. Evaluation of macular microcirculation in healthy children using optical coherence tomography angiography

      Evaluation of macular microcirculation in healthy children using optical coherence tomography angiography

      INTRODUCTION: To evaluate the macular perfusion using OCTA in a healthy pediatric population. METHODS: Fifty-three eyes of 30 healthy children (20 boys and 10 girls) were included in this prospective cross-sectional study. Age (years), gender, foveal thickness (FT) (µm), superficial foveal avascular zone area (FAZs) (%), deep foveal avascular zone area (FAZd) (%), superficial capillary plexus (SCP) flow area (%), deep capillary plexus (DCP) flow area (%), choriocapillaris (CC) flow area (%), vascular density in SCP (VDs) (%), vascular density in DCP (VDd) (%), and subfoveal choroidal thickness (SFCT) (µm) were evaluated. RESULTS: The mean age was 12.0± 4.0 (range: 6-15) years. Gender did not ...

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    8. Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration

      The advent of optical coherence tomography angiography (OCTA) has allowed for remarkable advancements in our understanding of the role of the choriocapillaris in age-related macular degeneration (AMD). As a relatively new imaging modality, techniques to analyze and quantify choriocapillaris images are still evolving. Quantification of the choriocapillaris requires careful consideration of many factors, including the type of OCTA device, segmentation of the choriocapillaris slab, image processing techniques, and thresholding method. OCTA imaging shows that the choriocapillaris is impaired in intermediate non-neovascular AMD, and the severity of impairment may predict the advancement of disease. In advanced atrophic AMD, the choriocapillaris is ...

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    9. Structural OCT Parameters Associated with Treatment Response and Macular Neovascularization Onset in Central Serous Chorioretinopathy

      Structural OCT Parameters Associated with Treatment Response and Macular Neovascularization Onset in Central Serous Chorioretinopathy

      Introduction: This study aimed to assess quantitative factors associated with treatment response and macular neovascularization (MNV) onset in central serous chorioretinopathy (CSC) through an artificial intelligence-based approach. Methods: The study was designed as an interventional, prospective case series with a planned follow-up of 36 months. We included only eyes demonstrating the first episode of CSC. All the patients underwent eplerenone or photodynamic therapy (PDT) treatment. Eyes developing MNV underwent anti-VEGF injections. We developed an artificial intelligence-based model to assess predictive quantitative structural optical coherence tomography (OCT) factors related to treatment response and onset of MNV. Main outcome measures were best-correct ...

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    10. Impact of optical coherence tomography scan direction on the reliability of peripapillary retinal nerve fiber layer measurements

      Impact of optical coherence tomography scan direction on the reliability of peripapillary retinal nerve fiber layer measurements

      Purpose To evaluate the intradevice repeatability and agreement for peripapillary retinal nerve fiber layer (pRNFL) measurements in healthy eyes with two different scan directions and two different number of B scans. Methods pRNFL was measured with a spectral domain optical coherence tomography on 54 healthy participants. Three-dimensional optic disc scans (6 mm x 6 mm) were performed on the right eye of the participants. Two repeated scans were performed in four different settings: H1: Horizontal scan with 512 A-scans x 96 B-scans; H2: Horizontal scan with 512 A-scans x 128 B-scans; V1: Vertical scan with 512 A-scans x 96 B-scans ...

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      Mentions: Huvitz
    11. Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes

      Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes

      Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total, superficial, and deep capillary plexus layers (TCP, SCP, and DCP) by optical coherence tomography angiography. All measurement points were classified into four categories according to intensity of fluorescein leakage and FD, and the RS reduction was compared. A stratified analysis by retinal thickness (RT) was also performed. Fourteen eyes (14 patients) were enrolled. FDs at 207 RS ...

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    12. Optical coherence tomography angiography for the diagnosis of granulomatosis with polyangiitis with serous retinal detachment

      Optical coherence tomography angiography for the diagnosis of granulomatosis with polyangiitis with serous retinal detachment

      Rationale: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease of unknown etiology. GPA affects multiple ocular tissues, most commonly the orbit, conjunctiva, cornea, and sclera. Retinal and choroidal manifestations are rare in GPA, but they often include choroidal neovascularization (CNV). Patient concerns: A 36-year-old man was diagnosed with GPA. He had been taking oral steroid treatment for 8 years. He experienced disease recurrence and the dose of oral prednisolone was increased after steroid pulse therapy. Fundus examination showed small retinal pigment epithelial detachment and serous retinal detachment (SRD). Optical coherence tomography (OCT) revealed a protruded lesion inside the ...

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    13. Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Purpose To assess the in vivo physiology of retinal reattachment in humans using swept-source optical coherence tomography (SS-OCT) in real-time. Design Prospective case series. Methods Fifteen consecutive patients with fovea-involving rhegmatogenous retinal detachment undergoing pneumatic retinopexy (PnR). SS-OCT was performed at presentation and frequent intervals immediately following PnR. Primary outcome was longitudinal assessment of early post-operative SS-OCT to establish stages of reattachment. Results 93.3% (14/15) achieved successful reattachment at the median follow-up duration of 13 weeks (IQR 7.5-18.0). Reattachment occurred in five specific stages: Stage 1, redistribution of fluid and approach of the neurosensory retina towards ...

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    14. Remote monitoring with Home OCT

      Remote monitoring with Home OCT

      In this video, Anat Loewenstein, MD, MHA, speaks about a Home OCT device. This technology has been tested in studies, and patients have been given the chance to try it at home, following a few, simple instructions. Some of them also speak here. Home monitoring is one of the most promising new frontiers in healthcare, leading to: reduced number of patient visits reduced patient burden increased safety in the time of COVID-19 more frequent, consistent gathering and assessment of data timely, personalized treatment schedules

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      Mentions: Notal Vision
    15. OCT-GAN: single step shadow and noise removal from optical coherence tomography images of the human optic nerve head

      OCT-GAN: single step shadow and noise removal from optical coherence tomography images of the human optic nerve head

      Speckle noise and retinal shadows within OCT B-scans occlude important edges, fine textures and deep tissues, preventing accurate and robust diagnosis by algorithms and clinicians. We developed a single process that successfully removed both noise and retinal shadows from unseen single-frame B-scans within 10.4ms. Mean average gradient magnitude (AGM) for the proposed algorithm was 57.2% higher than current state-of-the-art, while mean peak signal to noise ratio (PSNR), contrast to noise ratio (CNR), and structural similarity index metric (SSIM) increased by 11.1%, 154% and 187% respectively compared to single-frame B-scans. Mean intralayer contrast (ILC) improvement for the retinal ...

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    16. Optical coherence tomography analyses based segmentation and relative intensity evaluation of outer retinal layers in patients affected with X-linked juvenile retinoschisis

      Optical coherence tomography analyses based segmentation and relative intensity evaluation of outer retinal layers in patients affected with X-linked juvenile retinoschisis

      Purpose: We aim to provide a description of the optical coherence tomography findings in the outer macula hyperreflective bands of our patients with X-linked juvenile retinoschisis. Also to categorize these changes and to quantitatively and qualitatively correlate their reflectivity levels with visual function. Methods: We manually segmented the borders, and depicted relative intensity of the inner segment ellipsoid band, and quantified the volume of edema. Results: The average relative intensity of the ellipsoid zone, ISe band, for the control subject was 14.864, our patient’s, with the mild disease was, 28.238 and 34.943 in OD and OS ...

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    17. Multimodal imaging for paracentral acute maculopathy; the diagnostic role of en face OCT

      Multimodal imaging for paracentral acute maculopathy; the diagnostic role of en face OCT

      Background To describe the features of multimodal imaging and the diagnostic role of en face OCT in the paracentral acute middle maculopathy (PAMM) spectrum. Methods In this observational case series, 5 eyes of 5 patients with acute PAMM were identified. Demographic characteristics as well as data regarding the underlying disease, presenting visual acuity (VA) and ophthalmic examination results were recorded. All patients underwent multimodal imaging within 3 days after symptom onset. Results The mean age of patients was 52.2 (range, 33–67) years. Systemic comorbidities including diabetes mellitus and hypertension were identified in two patients. Except for one patient ...

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    18. Myths Associated With Optical Coherence Tomography for Glaucoma

      Myths Associated With Optical Coherence Tomography for Glaucoma

      D onald C. Hood, PhD, is the James F. Bender Professor of Psychology and Professor of Ophthalmic Sciences at Columbia University in New York, New York. His work has focused on improving the utility of optical coherence tomography (OCT) imaging in glaucoma treatment. He lectures on the lessons he has learned about the use of OCT, and how these lessons can aid the clinician in understanding and diagnosing glaucoma. Here, Glaucoma Physician talks with Dr. Hood about myths he believes glaucoma specialists hold about OCT for glaucoma. Q: How is OCT currently used in glaucoma management? A: Optical coherence tomography ...

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    19. Susana Marcos to lead Center for Visual Science

      Susana Marcos to lead Center for Visual Science

      Internationally recognized pioneer in vision science and its applications is named the next director of one of the University’s most highly regarded research centers. (Courtesy of Susana Marcos) Susana Marcos, an internationally recognized expert in the optics of the eye and the interactions of light with the retina, will become the David R. Williams Director of the Center for Visual Science at the University of Rochester . Her appointment will take effect July 1. The named position is endowed with a $2 million gift from John and Barbara Bruning. John, a member of the University’s Board of Trustees and ...

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    20. Optical Coherence Tomography Biomarkers - Vitreous Status Influence in Outcomes for Diabetic Macular Edema Therapy with 0.19 mg Fluocinolone Acetonide Implant

      Optical Coherence Tomography Biomarkers - Vitreous Status Influence in Outcomes for Diabetic Macular Edema Therapy with 0.19 mg Fluocinolone Acetonide Implant

      Background: The 0.19 mg fluocinolone acetonide (FAc) implant (ILUVIEN®; Alimera Sciences Ltd, Hampshire, UK) was approved for the treatment of vision impairment associated with chronic and refractory diabetic macular edema (DME). Objectives: To quantitatively assess functional and structural features in non-vitrectomized and vitrectomized DME patients after being treated with a FAc implant Methods: Retrospective review of patients with DME receiving single intravitreal injection of the FAc implant. The study was designed to analyze the presence of quantitative structural OCT biomarkers at baseline and 12 months after FAc therapy according to vitreous status. Results: A total of 41 eyes from ...

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    21. Utilisation of poor-quality optical coherence tomography scans: adjustment algorithm from the Singapore Epidemiology of Eye Diseases (SEED) study

      Utilisation of poor-quality optical coherence tomography scans: adjustment algorithm from the Singapore Epidemiology of Eye Diseases (SEED) study

      Purpose To evaluate the effect of signal strength (SS) on optical coherence tomography (OCT) parameters, and devise an algorithm to adjust the effect, when acceptable SS cannot be obtained. Methods 5085 individuals (9582 eyes), aged ≥40 years from the Singapore Epidemiology of Eye Diseases population-based study were included. Everyone underwent a standardised ocular examination and imaging with Cirrus HD-OCT. Effect of SS was evaluated using multiple structural breaks linear mixed-effect models. Expected change for increment in SS between 4 and 10 for individual parameter was calculated. Subsequently we devised and evaluated an algorithm to adjust OCT parameters to higher SS ...

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    22. Integrated Intraoperative Optical Coherence Tomography in Pediatric Glaucoma Surgery (Textbook)

      Integrated Intraoperative Optical Coherence Tomography in Pediatric Glaucoma Surgery (Textbook)

      The advent of integrated intraoperative optical coherence tomography (i 2 OCT) has opened the door for safer and more complex surgeries in the retina and cornea. However, to limit its use to just two subspecialties within ophthalmology is an opportunity lost for many other subspecialties. Here, we describe the use of i 2 OCT in pediatric glaucoma surgery. It can be used to identify Schlemm’s canal, Barkan’s membrane, demonstrate the corneal pathology in Haab’s striae, and iris hypoplasia in cases of Axenfeld-Rieger anomaly. It can help identify drainage blebs that are filtering and those that are not ...

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