1. Articles in category: Ophthalmology

    1-24 of 6196 1 2 3 4 ... 257 258 259 »
    1. Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules

      Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules

      Purpose : To characterize nodular lesions of the retina and optic nerve with spectral-domain optical coherence tomography (SD-OCT) in patients with sarcoidosis. Methods : This is a retrospective series of 6 eyes from 5 patients with an established diagnosis of sarcoidosis, with clinically detected nodules of the optic nerve or retina. All lesions were imaged with fundus photography and SD-OCT on presentation, and followed with serial imaging after treatment with corticosteroids and/or immunomodulatory therapy. Results : Spectral OCT through the lesions revealed nodular hyperreflective processes obscuring the retinal layers or optic cup, with local structural changes, including subretinal and intraretinal fluid. After ...

      Read Full Article
    2. Optical coherence tomography and confocal microscopy following 3 different protocols of corneal collagen-crosslinking in keratoconus.

      Optical coherence tomography and confocal microscopy following 3 different protocols of corneal collagen-crosslinking in keratoconus.

      Purpose: To compare the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated collagen cross-linking (A-CXL) in keratoconus. Methods: 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen crosslinking (CXL) were divided into 3 groups: C-CXL (n=15), A-CXL (n=15) and I-CXL (n=15). Patients were examined before surgery and at 1-month, 3-month, and 6-month intervals following surgery. Density of corneal sub-basal nerves, anterior and posterior keratocytes, corneal endothelium, demarcation line depth and maximal simulated keratometry values (Kmax) were all assessed. Results: Compared with preoperative values, the mean ...

      Read Full Article
    3. Peripapillary rat sclera investigated in vivo with polarization sensitive optical coherence tomography

      Peripapillary rat sclera investigated in vivo with polarization sensitive optical coherence tomography

      Purpose: To demonstrate polarization sensitive (PS) optical coherence tomography (OCT) for non-invasive, volumetric, and quantitative imaging of the birefringent properties of the peripapillary rat sclera. To compare the findings in PS-OCT images to state-of-the-art histomorphometric analysis of the same tissues. Methods: A high-speed PS-OCT prototype operating at 840 nm was modified for imaging the rat eye. Densely sampled PS-OCT raster scans covering an area of ~1.5 mm × 1.5 mm centered at the papilla were acquired in the eyes of anesthetized, male Sprague Dawley rats. Cross-sectional PS-OCT images were computed and fundus maps displaying the birefringent properties of the ...

      Read Full Article
    4. Enhanced depth imaging optical coherence tomography of congenital cavitary optic disc anomaly (CODA)

      Enhanced depth imaging optical coherence tomography of congenital cavitary optic disc anomaly (CODA)

      Aim To report the finding of extension of the 4th hyper-reflective band and retinal tissue into the optic disc in patients with cavitary optic disc anomalies (CODAs). Methods In this observational study, 10 patients (18 eyes) with sporadic or autosomal dominant CODA were evaluated with enhanced depth imaging optical coherence tomography (EDI-OCT) and colour fundus images for the presence of 4th hyper-reflective band extension into the optic disc. Results Of 10 CODA patients (18 eyes), five patients (8 eyes) showed a definite 4th hyper-reflective band (presumed retinal pigment epithelium (RPE)) extension into the optic disc. In these five patients (seven ...

      Read Full Article
    5. Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules

      Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules

      The authors present a case of sympathetic ophthalmia with Dalen–Fuchs nodules visualized with spectral-domain optical coherence tomography (SD-OCT). An 84-year-old man presented with floaters and decreased vision 25 years after penetrating trauma to the fellow eye. Examination revealed vitritis and subretinal lesions consistent with Dalen–Fuchs nodules. He was diagnosed with sympathetic ophthalmia after a negative systemic work-up. SD-OCT revealed hyper-reflective lesions at the level of the retinal pigment epithelium with disruption of the inner segment/outer segment (IS/OS) junction. Treatment resulted in clinical improvement and disappearance of Dalen–Fuchs nodules on SD-OCT; however, photoreceptor and retinal pigment ...

      Read Full Article
    6. Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      The aqueous outflow system (AOS) is responsible for maintaining normal intraocular pressure (IOP) in the eye. Structures of the AOS have an active role in regulating IOP in healthy eyes and these structures become abnormal in the eyes with glaucoma. We describe a newly developed system platform to obtain high-resolution images of the AOS structures. By incorporating spectral domain optical coherence tomography (SD-OCT), the platform allows us to systematically control, image, and quantitate the responses of AOS tissue to pressure with a millisecond resolution of pulsed flow. We use SD-OCT to image radial limbal segments from the surface of the ...

      Read Full Article
    7. Comparison of multifocal visual evoked potential, static automated perimetry, and optical coherence tomography findings for assessing visual pathways in patients with pituitary adenomas

      Comparison of multifocal visual evoked potential, static automated perimetry, and optical coherence tomography findings for assessing visual pathways in patients with pituitary adenomas

      Background There have been no studies investigating the correlation between structural [thickness of the retinal nerve fiber layer (RNFL) as determined by optical coherence tomography (OCT)] and functional [Humphrey visual field (HVF) or visual evoked potential (VEP) amplitude] measures of optic nerve integrity in patients with pituitary adenomas (PA). Methods Patients with PAs were recruited between September 2010 and September 2013. OCT, standard automated perimetry (SAP), and multifical VEP (mfVEP) were performed. Agreement between OCT, SAP, and mfVEP values in classifying eyes/quadrants was determined using AC1 statistics. Pearson’s correlation was used to examine relationships between structural and functional ...

      Read Full Article
      Mentions: Fudan University
    8. Reproducibility of Spectral-domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

      Reproducibility of Spectral-domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

      Purpose: To compare the reproducibility of the optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness map between glaucomatous and fellow normal eyes of unilateral glaucoma patients. Methods: In this prospective case-control study, Cirrus HD-OCT was performed for 79 unilateral glaucoma patients 3 times on the first visit and on 3 subsequent visits within a 2-month period. Test-retest standard deviation (TRT-SD) and tolerance limit based on the 1.645x[square root]2xTRT-SD formula were derived for RNFL thicknesses at the respective superpixels of the RNFL thickness map. Results: The TRT-SDs and tolerance limits of the glaucomatous eyes (TRT-SD: 2 ...

      Read Full Article
    9. A New OCT Finding in Tuberculous Serpiginous-like Choroidopathy

      A New OCT Finding in Tuberculous Serpiginous-like Choroidopathy

      Purpose : To present a case of tubercular serpiginous-like choroiditis (SLC) with previously unreported choroidal findings on enhanced depth imaging OCT (EDI-OCT). Design : Case report. Methods : A 60-year-old female presented with decreased vision. Serpiginous choroidopathy was diagnosed. Laboratory workup revealed an infectious etiology. EDI-OCT revealed previously unreported choroidal findings. Results: Laboratory workup revealed nonreactive Treponema pallidum antibodies and positive QuantiFERON Gold. CT chest showed scars of prior granulomatous disease. OCT with EDI of active lesions demonstrated infiltration of the choroid, elevation of the RPE-Bruch’s membrane complex and focal increase of choroidal thickness. Conclusions: Choroidal infiltration with elevation of the RPE ...

      Read Full Article
    10. Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

      Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

      Assessing the biomechanical properties of the cornea can provide clinically valuable information in addition to structural images for better management of pathologies (e.g. glaucoma) or refractive surgeries. OCT provides a micron scale and high sensitivity that are ideal for ophthalmic applications. We propose a shear wave elastography (SWE) method for the cornea based on phase-sensitive optical coherence tomography (PhS-OCT). SWE consists in launching a propagating shear wave in tissues and retrieving tissue elasticity from the shear wave speed. We used a piezo-electric actuator in contact with the cornea to induce shear waves that were then tracked using a PhSOCT ...

      Read Full Article
    11. Automated 3D Segmentation of Intraretinal Surfaces in SD-OCT Volumes in Normal and Diabetic Mice

      Automated 3D Segmentation of Intraretinal Surfaces in SD-OCT Volumes in Normal and Diabetic Mice

      Purpose: To describe an adaptation of an existing graph-theoretic method (initially developed for human optical coherence tomography [ OCT ] images) for the three-dimensional ( 3D ) automated segmentation of 10 intraretinal surfaces in mice scans, and assess the accuracy of the method and the reproducibility of thickness measurements. Methods: Ten intraretinal surfaces were segmented in repeat spectral domain ( SD )- OCT volumetric images acquired from normal ( n = 8) and diabetic ( n = 10) mice . The accuracy of the method was assessed by computing the border position errors of the automated segmentation with respect to manual tracings obtained from two experts. The reproducibility was statistically assessed ...

      Read Full Article
    12. Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

      Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

      Background The aim was to assess the macular parameters of glaucoma in highly myopic subjects. Methods In a retrospective study, we enrolled 72 highly myopic eyes (spherical equivalent up to -6.00 D), of which 31 had early to moderate glaucoma and 41 formed a control group. The diagnosis of early to moderate glaucoma was based on glaucomatous visual-field defects with a mean deviation better than -12 dB. All patients underwent imaging with Stratus optical coherence tomography. We subsequently performed analysis for macular volume and thickness parameters between two groups. Results Using Stratus optical coherence tomography, we found significantly lower ...

      Read Full Article
    13. Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma

      Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma

      Purpose To evaluate first and second order responses on multifocal electroretinogram (mfERG) and with retinal nerve fibre layer thickness (RNFL) on Cirrus spectral domain optical coherence tomography (SD-OCT) in glaucoma. Methods Patients (old and new) diagnosed with primary open angle glaucoma, primary angle closure glaucoma or normal tension glaucoma attending glaucoma services from November 2012 to January 2013 were screened. Ninety-seven eyes fulfilling inclusion criteria were evaluated by Humphrey visual field, Cirrus SD-OCT imaging and mfERG (Veris Science 5.1.10X; EDI, Redwood City, California, USA) for this observational cross-sectional study. The global and averaged quadrant-wise peak-to-trough amplitudes and peak ...

      Read Full Article
    14. Serial Spectral Domain Ocular Coherence Tomography Measurement of Outer Nuclear Layer Thickness in Rhegmatogenous Retinal Detachment Repair

      Serial Spectral Domain Ocular Coherence Tomography Measurement of Outer Nuclear Layer Thickness in Rhegmatogenous Retinal Detachment Repair

      Introduction : The outer nuclear layer (ONL) contains mostly photoreceptor bodies and reduced post-operative ONL thickness (ONLT) is associated with poor visual outcome in rhegmatogenous retinal detachment (RRD). Methods : Spectral domain ocular coherence tomography was recorded before and 6 weeks following RRD repair in 27 consecutive patients. Results : The repair consisted of combined 20-guage pars plana vitrectomy (PPV) and encirclement in 66.7% of cases, 22.2% underwent PPV alone and 11.1% scleral buckle alone. The mean (± standard deviation) ONLT was reduced in detached retinae (94.1 ± 31.1 microns) compared to the unaffected eye (119.5 ± 26.8 microns ...

      Read Full Article
    15. Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Neurodegeneration in dementia is mainly evaluated by assessing cerebral atrophy, while retinal neurodegeneration can be quantified in vivo using optical coherence tomography (OCT). We examined the association of retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC–IPL) thinning with global and regional cerebral atrophy on magnetic resonance imaging (MRI). Malay participants aged 60–80 years from the Epidemiology of Dementia in Singapore Study underwent comprehensive examinations, including 3-Tesla cranial MRI. RNFL and GC-IPL thicknesses were obtained from spectral domain-OCT; and cerebral grey and white matter volumes were obtained from MRI scans using a validated segmentation tool. Linear ...

      Read Full Article
    16. Spectral domain optical coherence tomography imaging in optic disk pit associated with outer retinal dehiscence

      Spectral domain optical coherence tomography  imaging in optic disk pit associated with outer  retinal dehiscence

      A 37-year-old Bangladeshi male presented with an inferotemporal optic disk pit and serous macular detachment in the left eye. Imaging with spectral domain optical coherence tomography (OCT) revealed a multilayer macular schisis pattern with a small subfoveal outer retinal dehiscence. This case illustrates a rare phenotype of optic disk maculopathy with macular schisis and a small outer retinal layer dehiscence. Spectral domain OCT was a useful adjunct in delineating the retinal layers in optic disk pit maculopathy, and revealed a small area of outer retinal layer dehiscence that could only have been detected on high-resolution OCT.

      Read Full Article
    17. Influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain OCT on the diagnostic ability of early glaucoma

      Influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain OCT on the diagnostic ability of early glaucoma

      Purpose: To investigate the influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain optical coherence tomography (OCT) on the diagnostic ability of early glaucoma. Methods: Sixty-four early (including 24 pre-perimetric) glaucomatous and 40 normal eyes underwent macular and peripapillary retinal nerve fiber layer (pRNFL) scans (3D-OCT-2000, Topcon). The area under the receiver operating characteristics (AUC) for glaucoma diagnosis was determined from the average thickness of the total 100 grids (6x6 mm), the central 44 grids (3.6x4.8 mm) and the peripheral 56 grids (outside of the 44 grids) and for each macular sublayer ...

      Read Full Article
    18. Correlations Amongst Near-Infrared and Short-Wavelength Autofluorescence and Spectral Domain Optical Coherence Tomography in Recessive Stargardt Disease

      Correlations Amongst Near-Infrared and Short-Wavelength Autofluorescence and Spectral Domain Optical Coherence Tomography in Recessive Stargardt Disease

      Purpose: Short-wavelength (SW) fundus autofluorescence (AF) is considered to originate from lipofuscin in retinal pigment epithelium (RPE) and near-infrared (NIR) AF from melanin. In patients with recessive Stargardt disease (STGD1), we correlated SW-AF and NIR-AF with structural information obtained by spectral domain optical coherence tomography (SD-OCT). Methods: Twenty-four STGD1 patients (45 eyes; age 8 to 61 years) carrying confirmed disease-associated ABCA4 mutations were studied prospectively. SW-AF, NIR-AF and SD-OCT images were acquired. Results: Five phenotypes were identified according to features of the central lesion and extent of fundus change. Central zones of reduced NIR-AF were typically larger than areas of ...

      Read Full Article
    19. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      With great interest we read the article by Garcia-Martin et al.1 The authors were able to include an impressively large number of patients and this dataset provides an excellent opportunity to evaluate retinal layer affection in multiple sclerosis. However, after carefully reading the article, we are concerned that there are discrepancies in the document that require clarification.

      Read Full Article
    20. Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Purpose To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA). Methods The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects. Results The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber ...

      Read Full Article
    21. Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Purpose To compare foveal shapes in Koreans according to age and gender using spectral domain optical coherence tomography (SD-OCT). Methods This study included 230 eyes of 115 healthy adults. The subjects were divided into three groups: group 1 (20-39 years of age), group 2 (40-59 years of age) and group 3 (60-79 years of age). Using spectralis OCT, we measured central foveal thickness (CFT), regional maximal retinal thickness (MRT), pit diameter and pit depth and compared the differences between the groups. Results The MRT of the superior, inferior and nasal sides in group 1 was higher than in groups 2 ...

      Read Full Article
    22. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...

      Read Full Article
    23. Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young, and elderly subjects. Methods: Doppler FD-OCT blood flow was measured using the RTVue system (Optovue Inc., USA). One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ± 5.1 years) subjects was randomly selected and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e. each separate measurement comprising an upper, and ...

      Read Full Article
    1-24 of 6196 1 2 3 4 ... 257 258 259 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (4 articles) UCLA
    2. (4 articles) University of Washington
    3. (3 articles) Sun Yat-Sen University
    4. (3 articles) Oregon Health & Science University
    5. (3 articles) Yonsei University
    6. (3 articles) University of Southern California
    7. (3 articles) Medical University of Vienna
    8. (3 articles) National Institutes of Health
    9. (3 articles) Northwestern University
    10. (2 articles) University of Wisconsin
    11. (2 articles) University College London
    12. (2 articles) Harvard University
  4. People in the News

    1. (4 articles) Srinivas R. Sadda
    2. (3 articles) Philip J. Rosenfeld
    3. (3 articles) Richard F. Spaide
    4. (3 articles) Ruikang K. Wang
    5. (2 articles) Giovanni Gregori
    6. (2 articles) Vikas Chopra
    7. (2 articles) Carmen A. Puliafito
    8. (1 articles) Shan C. Lin
    9. (1 articles) Erich Götzinger
    10. (1 articles) Ludwin Monz
    11. (1 articles) Harsha L. Rao
    12. (1 articles) Kirill V. Larin
  5. OCT Companies in the News

    1. (12 articles) Carl Zeiss Meditec
    2. (5 articles) Heidelberg Engineering
    3. (2 articles) Topcon Medical Systems
    4. (1 articles) Praevium Research
    5. (1 articles) Tomey Corporation
    6. (1 articles) Optovue
    7. (1 articles) Optopol Technology
    8. (1 articles) Haag-Streit
    9. (1 articles) Optos
  6. OCT Products in the News

    1. (11 articles) Zeiss Cirrus HD-OCT
    2. (8 articles) Heidelberg Spectralis
    3. (2 articles) Zeiss Visante OCT
    4. (2 articles) Zeiss Stratus OCT
    5. (1 articles) Optovue RTVue-100
    6. (1 articles) Tomey SS-1000 CASIA
    7. (1 articles) Topcon 3D OCT-2000