1. Articles in category: Ophthalmology

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    1. Anterior Segment Imaging in Glaucoma

      Explore Informa Healthcare Ophthalmology
      Anterior Segment Imaging in Glaucoma

      Anterior segment imaging allows objective assessment of the anterior segment of the eye, particularly the anterior chamber angle. Both qualitative and quantitative analyses are possible and aid in detecting and managing closed-angle and open-angle mechanisms in various forms of glaucoma . This review focuses primarily on anterior segment optical coherence tomography and ultrasound biomicroscopy, with emphasis on principles of technology, commercially available devices, and clinical applications in glaucoma with potential advantages and disadvantages of each technology.

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    2. Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy

      Explore iovs.org Ophthalmology
      Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy

      Purpose: To correlate retinal function and visual sensitivity with retinal morphology revealed by ultrahigh-resolution imaging with adaptive optics -optical coherence tomography (AO-OCT), on patients with geographic atrophy. Methods: Five eyes from five subjects were tested [4 with geographic atrophy (66.3 ± 6.4 years, mean±1S.D.) and 1 normal (61 years)]. Photopic and scotopic multifocal electroretinograms (mfERGs) were recorded. Visual fields were assessed with microperimetry (mP) combined with a scanning laser ophthalmoscope for high-resolution confocal retinal fundus imaging. The eye tracker of the microperimeter identified the preferred retinal locus that was then used as a reference for precise targeting ...

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      Mentions: John S. Werner UC Davis Robert J. Zawadzki

    3. Assessment of OCT measurements as prognostic factors in myopic macular hole surgery without foveoschisis

      Explore Home - Springer Ophthalmology
      Assessment of OCT measurements as prognostic factors in myopic macular hole surgery without foveoschisis

      Background To assess the role of Spectral Domain Optical Coherence Tomography (SD-OCT) measurements as prognostic factors in myopic macular hole (MMH) surgery. Methods In a retrospective cohort study, we evaluated 42 eyes of 42 patients (Spherical equivalent > −6.00 D) who underwent pars plana vitrectomy with internal limiting membrane peeling for MMH without foveoschisis. Statistical analysis was performed to correlate postoperative best corrected visual acuity (BCVA) with preoperative BCVA, age, degree of myopia and seven preoperative OCT measurements: macular hole (MH) base, MH minimum diameter, MH height, Hole Form Factor (HFF), Macular Hole Index (MHI), Diameter Hole Index (DHI) and ...

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    4. Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-d-aspartate-induced retinal damage model

      Explore ScienceDirect Ophthalmology
      Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-d-aspartate-induced retinal damage model

      Spectral-domain optical coherence tomography (SD-OCT) is an interferometric optical tomography technique and provides high resolution and noninvasive visualization of retinal morphology. The purpose of this study was to assess the utility of thickness maps and quantitative thickness measurements of the ganglion cell complex (GCC: retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer) obtained by SD-OCT of a mouse model of N -methyl- d -aspartate (NMDA)-induced retinal damage. SD-OCT imaging was performed in ddY mice at 1, 3, and 7 days and 1 month after intravitreal injection of NMDA. GCC thickness maps and circle cross-sectional OCT images ...

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      Mentions: Yoshiaki Yasuno University of Tsukuba

    5. Photoreceptor Impairment and Restoration on Optical Coherence Tomographic Imag

      Explore Hindawi Publishing Corporation Ophthalmology
      Photoreceptor Impairment and Restoration on Optical Coherence Tomographic Imag

      With recent development of spectral-domain optical coherence tomography (SD-OCT), the pathological changes of retina can be observed in much greater detail. SD-OCT clearly delineates three highly reflective lines in the outer retina, which are external limiting membrane (ELM), photoreceptor inner and outer segment (IS/OS) junction, and cone outer segment tips (COST) in order from inside. These lines can serve as hallmarks for the evaluation of photoreceptor condition. In retinitis pigmentosa (RP) leading to photoreceptor degeneration, the ELM, IS/OS, and COST lines are shortened with the progression of the disease. In addition, shortening of the ELM, IS/OS and ...

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    6. Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema

      Explore Ophthalmology Ophthalmology
      Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema

      Objective To evaluate agreement between fluorescein angiography (FA) and optical coherence tomography (OCT) results for diagnosis of macular edema in patients with uveitis. Design Multicenter cross-sectional study. Participants Four hundred seventy-nine eyes with uveitis from 255 patients. Methods The macular status of dilated eyes with intermediate uveitis, posterior uveitis, or panuveitis was assessed via Stratus-3 OCT and FA. To evaluate agreement between the diagnostic approaches, κ statistics were used. Main Outcome Measures Macular thickening (MT; center point thickness, ≥240 μm per reading center grading of OCT images) and macular leakage (ML; central subfield fluorescein leakage, ≥0.44 disc areas per reading ...

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      Mentions: University of Wisconsin Duke University James P. Dunn

    7. Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Central Retinal Vein Occlusion

      Explore ScienceDirect Ophthalmology
      Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Central Retinal Vein Occlusion

      Purpose To evaluate subfoveal choroidal thickness in patients with central retinal vein occlusion (CRVO) using enhanced depth imaging optical coherence tomography. Design Retrospective observational study. Methods We measured bilateral subfoveal choroidal thickness, averaged for 100 scans, in 36 patients (mean age, 66 ± 15 years; 26 women and 10 men) with unilateral CRVO by using the enhanced depth imaging methods of the Spectralis optical coherence tomography system. Twenty-two patients were treated with intravitreal bevacizumab (1.25 mg/0.05 mL), and subfoveal choroidal thickness was measured before and after treatment. Statistical analysis was performed to compare subfoveal choroidal thickness of CRVO ...

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      Mentions: Heidelberg Spectralis

    8. Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

      Explore PLoS ONE Ophthalmology
      Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

      Experimental autoimmune uveoretinitis (EAU) in mice is a model for human autoimmune uveitis. Longitudinal follow-up is only possible by non-invasive techniques, but the information obtained by visual fundus examination can be limited. We therefore evaluated the efficacy of optical coherence tomography (OCT) and electroretinography (ERG) to monitor pathological and functional changes of the retina in vivo. OCT imaging and ERG recording as a measure of visual function were compared with visual fundoscopic imaging and histology findings in the same mouse. Our results showed that OCT imaging of the retina was well correlated with clinical and histological observations in mice during ...

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      Mentions: National Institutes of Health Sun Yat-Sen University National Eye Institute

    9. Neovascular Glaucoma Induced by Peripheral Retinal Ischemia in Neurofibromatosis Type 1: Management and Imaging Features

      Explore Karger Publishers Ophthalmology
      Neovascular Glaucoma Induced by Peripheral Retinal Ischemia in Neurofibromatosis Type 1: Management and Imaging Features

      Purpose: To report the case of a young patient affected by neurofibromatosis 1 (NF-1) with peripheral retinal ischemia-induced neovascular glaucoma and the peculiar spectral-domain optical coherence tomography (SD-OCT) features. Material and Methods: A 13-year-old boy affected by NF-1, as diagnosed according to established criteria, was referred with a diagnosis of hypertensive uveitis in his left eye. He underwent a complete ophthalmic examination and comprehensive blood work with viral and immunological tests. The case was documented with fluorescein angiography (FA) and SD-OCT. When the intraocular pressure (IOP) of the left eye decreased and the cornea cleared, FA revealed retinal ischemia and ...

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    10. Anterior Segment Optical Coherence Tomography: Assisted Topographic Corneal Epithelial Thickness Distribution Imaging of a Keratoconus Patient

      Explore Karger Publishers Ophthalmology
      Anterior Segment Optical Coherence Tomography: Assisted Topographic Corneal Epithelial Thickness Distribution Imaging of a Keratoconus Patient

      PURPOSE: To evaluate safety, efficacy and ease of measurement of epithelial thickness in a keratoconic patient based on anterior segment optical coherence tomography (AS-OCT). METHODS: A 25-year-old male patient, previously diagnosed with keratoconus, with highly asymmetric manifestation among the two eyes, was subjected to AS-OCT corneal epithelial imaging. We investigated epithelial thickness and epithelial topographic thickness distribution. RESULTS: Mean epithelial thickness was 51.97 ± 0.70 for the less affected right eye (OD), and 55.65 ± 1.22 for the more affected left eye (OS). Topographic epithelial thickness variability for the OD was 1.53 ± 0.21 μm, while for ...

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    11. The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings

      Explore Ophthalmology Ophthalmology
      The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings

      Purpose To report and analyze the spectral-domain optical coherence tomography (SD-OCT) features of the posterior pole and papillomacular fold (PMF) in posterior microphthalmos (PM) in relation to axial length of the globe and corneal power. Design Comparative case series. Participants Forty eyes of 20 PM patients and 70 eyes of 35 age-matched controls. Methods All PM and control eyes underwent a full biometric evaluation, including axial length and corneal power measurements, and macular SD-OCT. In addition, a novel SD-OCT marker of the posterior pole curvature, termed the posterior pole curvature index (PPCI), was measured along both the vertical and horizontal ...

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    12. Longitudinal fundus and retinal studies with SD-OCT: a comparison of five mouse inbred strains

      Explore Home - Springer Ophthalmology
      Longitudinal fundus and retinal studies with SD-OCT: a comparison of five mouse inbred strains

      Spectral domain optical coherence tomography (SD-OCT) has recently been established as a method for in vivo imaging of fundus and retina in the mouse. It enables more effective studies of retinal diseases including investigations of etiopathologic mechanisms. In order to learn more about longitudinal fundus development and to enable recognition of disease-associated irregularities, we performed confocal scanning laser ophthalmoscopy (cSLO) and SD-OCT measurements in the inbred strains C57BL/6J, C3HeB/FeJ, FVB/NCrl, BALB/cByJ, and 129S2/SvJ when they were between 2 and 6 months of age. In general, cSLO and SD-OCT data did not reveal sex-specific or unilateral ...

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      Mentions: Technical University of Munich

    13. Influence of Cataract Surgery on Optical Coherence Tomography and Neurophysiology Measurements in Patients With Retinitis Pigmentosa

      Explore American Journal of Ophthalmology Ophthalmology
      Influence of Cataract Surgery on Optical Coherence Tomography and Neurophysiology Measurements in Patients With Retinitis Pigmentosa

      Purpose To evaluate the effect of uncomplicated cataract phacoemulsification on the measurements of visual evoked potentials (VEP), pattern electroretinogram (PERG), and macular and retinal nerve fiber layer (RNFL) using 2 spectral-domain optical coherence tomography (OCT) instruments, the Cirrus OCT (Carl Zeiss Meditech) and Spectralis OCT (Heidelberg Engineering), in patients with retinitis pigmentosa (RP), and to assess the reliability of the OCT measurements before and after cataract surgery. Design Observational cross-sectional study. Methods Thirty-five eyes of 35 patients with RP (20 men and 15 women, 45-66 years) who underwent cataract phacoemulsification were studied. At 1 month before and 1 month after ...

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      Mentions: Heidelberg Engineering Carl Zeiss Meditec Miguel Servet University Hospital

    14. Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

      Explore Healio.com Ophthalmology
      Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

      BACKGROUND AND OBJECTIVE: To analyze choroidal morphology and vascular layers in eyes with retinitis pigmentosa (RP) using spectral-domain optical coherence tomography. PATIENTS AND METHODS: Cross-sectional, retrospective analysis of 14 patients (14 eyes) with RP and 33 healthy subjects (33 eyes) who underwent high-definition one-line raster scanning at a single center. Two independent raters evaluated the morphology, thickness, and vascular layers of the choroid in both groups. RESULTS: The choroid had an irregular shape in 11 of 14 eyes (79%) with RP. The thickest point of choroid was not subfoveal as in healthy eyes, and exaggerated nasal thinning of the choroid ...

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      Mentions: Optovue Jay S. Duker University of São Paulo

    15. Congenital Hypertrophy of the Retinal Pigment Epithelium: Choroidal Cavitation Demonstrated on Spectral-Domain OCT

      Explore Healio.com Ophthalmology
      Congenital Hypertrophy of the Retinal Pigment Epithelium: Choroidal Cavitation Demonstrated on Spectral-Domain OCT

      A patient with solitary congenital hypertrophy of the retinal pigment epithelium demonstrated a striking choroidal cavitation on spectral-domain optical coherence tomography (OCT). Although photoreceptor atrophy overlying congenital hypertrophy of the retinal pigment epithelium has been described on time-domain OCT, this patient manifested a previously unrecognized tomographic feature.

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    16. Multimodal Imaging of Optic Disc Drusen

      Explore American Journal of Ophthalmology Ophthalmology
      Multimodal Imaging of Optic Disc Drusen

      Purpose To evaluate optic disc drusen, extracellular protein deposits known to contain numerous aggregates of mitochondria, using multimodal modalities featuring optical coherence tomography (OCT) and autofluorescence imaging. Design Retrospective observational case series. Methods Eyes with optic nerve drusen were examined with enhanced depth imaging (EDI)-OCT, swept source OCT, and fundus autofluorescence using a fundus camera. Results Twenty-six eyes of 15 patients with optic disc drusen were evaluated. EDI-OCT and swept source OCT showed multiple optic disc drusen at different levels; most were located immediately anterior to the lamina cribrosa. The drusen were ovoid regions of lower reflectivity that were ...

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      Mentions: Richard F. Spaide

    17. Choroidal Thickness Measurement in Myopic Eyes by Enhanced Depth Optical Coherence Tomography

      Explore Ophthalmology Ophthalmology
      Choroidal Thickness Measurement in Myopic Eyes by Enhanced Depth Optical Coherence Tomography

      Purpose To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI). Design A cross-sectional study. Participants Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated. Methods Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm ...

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      Mentions: Sun Yat-Sen University Dennis S. C. Lam The Chinese University of Hong Kong

    18. In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

      Explore BJO Online Dermatology , Ophthalmology
      In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

      Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC). Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The ...

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      Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight

    19. Choroidal thinning in high myopia measured by optical coherence tomography

      Explore Medical Journals Publisher Ophthalmology
      Choroidal thinning in high myopia measured by optical coherence tomography

      Purpose: To investigate the rate of choroidal thinning in highly myopic eyes. Patients and methods: A retrospective observational study of 37 eyes of 26 subjects (nine males and 17 females, mean age 39.6 ± 7.7 years) with high myopia but no pathologies who had undergone spectral domain optical coherence tomography and repeated the test 1 year later (1 ± 0.25 year) at Osaka University Hospital, Osaka, Japan. Patients older than 50 years with visual acuity worse than 20/40 or with whitish chorioretinal atrophy involving the macula were excluded. Two masked raters measured the choroidal thicknesses (CTs) at the ...

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      Mentions: Osaka University Yasushi Ikuno

    20. Carl Zeiss Meditec improves its results in first six months of financial year 2012/2013

      Explore Aktien Ophthalmology , Other Business News
      Carl Zeiss Meditec improves its results in first six months of financial year 2012/2013

      The Ophthalmic Systems SBU was affected by a high level of competition. The effects of the model change in the area of optical coherence tomography (OCT) also impacted this SBU. A 4.9% decline in revenue to € 175.8 million was countered in the first six months of the year by a positive trend in incoming orders, which slightly surpasses the previous year's level.

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      Mentions: Carl Zeiss Meditec Ludwin Monz

    21. Assessment of Schlemm’s canal in a normal human eye by swept source optical coherence tomography

      Explore IOPscience Ophthalmology
      Assessment of Schlemm’s canal in a normal human eye by swept source optical coherence tomography

      We have applied custom-built anterior segment optical coherence tomography based on a 1310 nm center wavelength swept laser source to measure Schlemm's canal (SC) area in the living human eye. A total of 50 healthy volunteers with 100 normal eyes have been measured on the nasal and temporal sides successfully. The statistical results show that there are no significant differences between females and males in respect of SC area (female: 8062.24 μm2 ± 1492.304 μm2; male: 7714.52 μm2 ± 1439.034 μm2; p = 0.095), and also no significant differences of SC area are ...

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      Mentions: Fudan University Chinese Academy of Sciences

    22. Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Explore Home - Springer Ophthalmology
      Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Purpose To present a selected case series of different phenotypes of the normal outer plexiform layer (OPL) visualized by optical coherence tomography (OCT). Methods Five cases were selected to represent the spectrum of appearances of the OPL in this case series. Categorical descriptions of each manifestation were then developed. Additional SD-OCT scans were obtained from a normal volunteer to further support the hypothesis. Results The inner one-third of the OPL typically appears hyperreflective on OCT, while the outer two-thirds (Henle fiber layer) may have a more varied appearance. Six different phenotypes of Henle fiber layer reflectivity were noted in this ...

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      Mentions: Alexander C. Walsh University of Southern California Gadi Wollstein

    23. A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      Explore Ophthalmology Ophthalmology
      A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      Purpose To assess the repeatability and reproducibility of 3 rotating Scheimpflug cameras, the Pentacam (Oculus, Wetzlar, Germany), Sirius (Costruzione Strumenti Oftalmici, Florence, Italy), and Galilei (Ziemer, Biel, Switzerland), and 1 Fourier-domain optical coherence tomography (FD-OCT) system, the RTvue-100 OCT (Optovue Inc., Fremont, CA), in measuring corneal thickness. Design Evaluation of diagnostic test. Participants Sixty-six right eyes of 66 healthy volunteers, whose mean age ± standard deviation (SD) was 35.39±10.06 years (range, 18–55 years). Methods Corneal thickness measurements obtained by each system included central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT), measured at ...

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      Mentions: Optovue Wenzhou Medical College Giacomo Savini

    24. Differentiation of Parapapillary Atrophy Using Spectral-Domain Optical Coherence Tomography

      Explore Ophthalmology Ophthalmology
      Differentiation of Parapapillary Atrophy Using Spectral-Domain Optical Coherence Tomography

      Purpose To develop a classification of parapapillary atrophy (PPA) based on its relationship with the location of Bruch's membrane (BM) termination in primary open-angle glaucoma (POAG) patients. Design Cross-sectional observational study. Participants This study analyzed 161 eyes from 161 POAG patients who had temporal β-zone PPA, the width of which was more than 200 μm on at least 1 horizontal scan image obtained by spectral-domain optical coherence tomography within the mid horizontal one third of the optic nerve. Methods Based on the extent of BM within the PPA area, eyes were categorized as group A (intact BM; 76 eyes ...

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      Mentions: Seoul National University UCSD Robert N. Weinreb
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