1. Articles in category: Ophthalmology

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    1. Guidelines on Optical Coherence Tomography Angiography Imaging: 2020 Focused Update

      Guidelines on Optical Coherence Tomography Angiography Imaging: 2020 Focused Update

      Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. In this review, we provide a discussion of the fundamental principles of OCTA and the application of this imaging modality to study the retinal and choroidal vessels. These guidelines are focused on 2020, and include updates since the 2019 publication. Importantly, we will comment on recent findings on OCTA technology with a special focus on the three-dimensional (3D) OCTA visualization.

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    2. Optical coherence tomography of the Tokay gecko (Gekko gecko) eye

      Optical coherence tomography of the Tokay gecko (Gekko gecko) eye

      Objective To provide images of the anterior and posterior structures of the gecko eye using spectral domain optical coherence tomography (SD‐OCT). Animals and procedures Eight ophthalmologically normal Tokay geckos ( Gekko gecko ) were used. The nose‐cloaca distance and body weight were measured for each gecko. Tomographic images were obtained using SD‐OCT without the use of anesthetic or mydriatic agents. The central corneal thickness (CCT), the anterior chamber depth (ACD), and the length of the conus papillaris (CP) were manually measured using OCT images. The thickness of the retinal nerve fiber layer (RNFL) around the CP and the retinal ...

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    3. Santec announces sales launch by Alcon of SS-OCT biometer for cataract specialists in Japan under the brand MOVU

      Santec announces sales launch by Alcon of SS-OCT biometer for cataract specialists in Japan under the brand MOVU

      Santec Corporation, a leading manufacturer of advanced optical components, tunable lasers, optical test equipment and OCT systems, today announced the sales launch, through Alcon Japan, of the Swept Source Optical Coherence Tomography (SS-OCT) biometer ARGOS ® (model name: ARGOS ® ver1.5.). The ARGOS ® , sold under the brand MOVU ® , incorporates Santec’s market leading SS-OCT technology and is used to measure key parameters of the eye, including axial length, prior to cataract surgery. "ARGOS ® Ver.1.5" integrates the biometric and surgical planning functions of the cataract surgery guide system “VERION™” and will be released in Japan on August 3, 2020. “VERION ...

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      Mentions: Santec FDA Alcon
    4. Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes with Exudative Circumscribed Choroidal Haemangioma : An Optical Coherence Tomography Angiography Study

      Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes with Exudative Circumscribed Choroidal Haemangioma : An Optical Coherence Tomography Angiography Study

      Background : To quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma (CCH) compared with age- and gender-controlled healthy eyes. Methods : This was a cross-sectional, case-control study. 82 eyes of eighty-two subjects including 41 eyes of forty-one subjects in the exudative CCH group and 41 eyes of forty-one subjects in the age- and gender-controlled healthy eye group were enrolled in this study. Optical coherence tomography angiography (OCTA) was performed in each subject, and the capillary density (CD) of superficial plexus, deep capillary plexus, and the choriocapillaris as well as the area of foveal avascular zone (FAZ) were ...

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    5. Management of Stromal Herpes Simplex Virus Keratitis With Epithelial Ulceration Using Optical Coherence Tomography–Generated Corneal Thickness Maps

      Management of Stromal Herpes Simplex Virus Keratitis With Epithelial Ulceration Using Optical Coherence Tomography–Generated Corneal Thickness Maps

      Purpose: To report 2 cases of herpes simplex virus (HSV) stromal keratitis with epithelial ulceration that were managed using optical coherence tomography–generated pachymetric and corneal epithelial thickness maps. Methods: Two patients with a history of HSV keratitis with nonhealing epithelial defects were referred to the Athens Vision Eye Institute. Anterior segment optical coherence tomography–generated pachymetric and corneal epithelial thickness maps showed subclinical stromal edema and irregular epithelium, thus indicating diagnoses of HSV stromal keratitis with epithelial ulceration. The patients were administered topical preservative-free dexamethasone and oral antiviral therapy. Steroid tapering was guided by pachymetric and corneal epithelial thickness ...

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      Mentions: Yale University
    6. Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome

      Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome

      Abstract The visual outcome of myopic choroidal neovascularization (CNV) after anti-vascular endothelial growth factor (anti-VEGF) therapy varies among individuals. We retrospectively analyzed the data of 24 eyes (24 patients) with treatment-naïve myopic CNV who underwent anti-VEGF monotherapy following a pro-re-nata regimen at the Division of Medical Retina Clinic, Department of Ophthalmology, Keio University Hospital between May 2014 and December 2017. The mean age was 70.6 ± 2.1 years, and 16 (66.7%) patients were female. Overall, the mean best-corrected visual acuity (BCVA) improved ( p = 0.034), and the mean height of the hyperreflective material (HRM), involving the CNV ...

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    7. Validation of inter-eye difference thresholds in optical coherence tomography for identification of optic neuritis in multiple sclerosis

      Validation of inter-eye difference thresholds in optical coherence tomography for identification of optic neuritis in multiple sclerosis

      Objective To examine and validate thresholds for inter-eye differences in peripapillary retinal nerve fibre (pRNFL) and ganglion cell + inner plexiform layer (GCIPL) thicknesses for identifying unilateral optic neuritis in MS. Methods In this two-centre, cross-sectional study, optical coherence tomography was performed in 340 patients with clinically isolated syndrome (CIS) and MS. Cut-off values of inter-eye difference for identification of eyes with a history of unilateral ON were evaluated by receiver-operating characteristics analysis. Results For pRNFL ≥5 µm, sensitivity was 69% and specificity 68%, while for GCIPL ≥4 µm sensitivity was 67% and specificity 78%. The areas under the curve (AUC ...

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    8. Neuroaxonal Degeneration in Patients With Multiple Sclerosis: An Optical Coherence Tomography and in Vivo Corneal Confocal Microscopy Study

      Neuroaxonal Degeneration in Patients With Multiple Sclerosis: An Optical Coherence Tomography and in Vivo Corneal Confocal Microscopy Study

      urpose: To investigate the effect of multiple sclerosis (MS) on corneal and retinal nerve fiber by quantifying corneal subbasal nerve fibers and retinal ganglion cells. Methods: A total of 46 eyes of 23 patients with MS and 42 eyes of 21 healthy subjects were included in the study. All patients and healthy subjects underwent a comprehensive ocular examination. In vivo confocal microscopy with Heidelberg Retina Tomograph in association with Rostock Cornea Module (Heidelberg Engineering, Heidelberg, Germany) and a swept-source optical coherence tomography (Topcon Corporation) were performed in all patients and healthy subjects. The number of subbasal nerve fibers and the ...

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    9. Optical Coherent Tomography Predicts Long-Term Visual Outcome of Pituitary Adenoma Surgery: New Perspectives From a 5-Year Follow-up Study

      Optical Coherent Tomography Predicts Long-Term Visual Outcome of Pituitary Adenoma Surgery: New Perspectives From a 5-Year Follow-up Study

      BACKGROUND Compressive optic neuropathy is the most common indication for transsphenoidal surgery for pituitary adenomas. Optical coherence tomography (OCT) is a useful visual assessment tool for predicting postoperative visual field recovery. OBJECTIVE To analyze visual parameters and their association based on long-term follow-up. METHODS Only pituitary adenoma patients with abnormal visual field defects were selected. A total of 188 eyes from 113 patients assessed by visual field index (VFI) and 262 eyes from 155 patients assessed by mean deviation (MD) were enrolled in this study. Postoperative VFI, MD, and retinal nerve fiber layer (RNFL) thickness were evaluated and followed up ...

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    10. OCT angiography improves views of retina blood flow

      OCT angiography improves views of retina blood flow

      Projects from Boston and Portland could help translation of OCTA into clinics. Retina blood flow: vital for diagnosis Optical coherence tomography angiography (OCTA) is a promising technique for imaging of blood vessels, in which sequential OCT scans of the same tissue cross-section reveal the sites of blood flow within those tissues, and can allow the blood oxygen content to be calculated. Examination of the retina is one promising application area for OCTA, thanks partly to the widespread adoption of conventional OCT within ophthalmology and its established place in clinical workflows. Two recent projects have published findings that could assist the ...

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    11. Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Aim To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis. Methods Members of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared with uveitis specialists (users) who have less than five publications on the field of uveitis and OCT-A. Results A total of 108 uveitis specialists who participated in the survey were ...

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    12. OCT-Angiography comparison between obstructive sleep apnea children and normal subjects in China

      OCT-Angiography comparison between obstructive sleep apnea children and normal subjects in China

      Purpose Using optical coherence tomography angiography (OCT-A) to compare the retinal micro vessel alteration between obstructive sleep apnea (OSA) children and normal subjects. Methods One hundred-thirty-two eyes (132 participants) were recruited in this study. The average age of OSA group (66 eyes) and healthy control group (66 eyes) were 6.23 ± 1.73 and 6.76 ±1.89 years, respectively). The retinal vascular network density indices and the fovea avascular zone (FAZ) size were analyzed by OCT-A. Results All of the OCT-A parafoveal vessel indices, including the vascular diameter (VD), vascular area density (VAD), vascular skeleton density (VSD), and vessel ...

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    13. Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy

      Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy

      Reduce the trauma and the time taken for patient rehabilitation. The prevailing trend is to perform a mitomycin- C (MMC)-augmented trabeculectomy and trabeculectomy with ologen implants in a trial to decrease bleb failure as a common post- trabeculectomy complication. Is to develop a measurement protocol by OCT-A imaging and characterization of the bleb vascularity changes in glaucoma patients before and after surgery.

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    14. Swept-source optical coherence tomography angiography vitreo-retinal segmentation in proliferative diabetic retinopathy

      Swept-source optical coherence tomography angiography vitreo-retinal segmentation in proliferative diabetic retinopathy

      Purpose: To identify a new cortical vitreous segmentation protocol for non invasive standardised investigation of Neovascularisation (NV) with detection of regression of NV activity in Proliferative Diabetic Retinopathy (PDR). Design: Retrospective study. Participants: One hundred and eighty-six eyes of 93 consecutive diabetic patients (mean age: 52.6 ± 11.0 years) imaged using Topcon Triton ® Swept-Source Optical Coherence Tomography Angiography (SS-OCTA) from June 2015 to January 2017. Methods: Scans were performed through the macula, optic disc and areas of possible NV in mid-peripheral retina using 6 × 6 mm and/or 9 × 9 mm raster-patterns in three segmentation protocols: Vitreo-Retinal (VRS), Outer-Vitreous ...

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    15. Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome

      Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome

      Objective To evaluate the ability of intereye retinal thickness difference (IETD) measured by optical coherence tomography (OCT) to detect asymptomatic optic nerve involvement in clinically isolated syndrome (CIS). Methods We conducted a cross-sectional study of patients who recently presented a CIS (≤4.5 months). All patients underwent OCT and brain/optic nerve MRI. Optic nerve involvement was defined clinically (episode of optic neuritis [ON] or not) and radiologically (optic nerve hypersignal on 3D double inversion recovery [3D-DIR]). We evaluated the sensitivity and specificity of previously published IETD thresholds and report the observed optimal thresholds for identifying symptomatic optic nerve involvement ...

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    16. Optical coherence tomography: A useful tool for identifying subclinical optic neuropathy in diagnosing multiple sclerosis

      Optical coherence tomography: A useful tool for identifying subclinical optic neuropathy in diagnosing multiple sclerosis

      Care of patients with multiple sclerosis (MS) has evolved in the last decade to shorten the time to confirm the diagnosis of clinically definite MS and to start disease-modifying drugs as soon as possible to decrease permanent disability and the risk of progressive disease. Such trends have been achieved by improving our understanding of the role of paraclinical tests such as the presence of oligoclonal bands on CSF examination, visual evoked potentials, or MRI imaging of the brain or spinal cord. Recently, the evidence that retinal damage detected with optical coherence tomography (OCT) is a sensitive test for identifying MS-related ...

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    17. Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study

      Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study

      Purpose : To investigate retinal neurovascular structural changes in patients with essential hypertension. Methods : This observational cross-sectional study consisted of 199 right eyes from 169 nondiabetic essential hypertensive patients, divided into groups as follows: group A, 113 patients with hypertensive retinopathy (HTNR); group B, 56 patients without HTNR; and a control group of 30 healthy subjects. Peripapillary retinal nerve fiber layer (RNFL), radial peripapillary segmented (RPC), ganglion cell–inner plexiform layer (GC-IPL), and superficial (SVP) and deep (DVP) vascular plexus density at the macula (6 × 6 mm 2 ) were measured by optical coherence tomography angiography (OCTA). Results : DVP density was significantly ...

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    18. Kubota Vision Demonstrates 3D Imaging Capabilities Using AI on PBOS

      Kubota Vision Demonstrates 3D Imaging Capabilities Using AI on PBOS

      Kubota Vision Inc. (“Kubota Vision”), a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596), today announced that the company demonstrated 3D imaging capabilities using artificial intelligence (AI) on our Patient Based Ophthalmology Suite (PBOS), in-home optical coherence tomography (OCT) device.*1 Kubota Vision completed a successful clinical study in October 2018 that demonstrated the PBOS could detect thinning and thickening of the human retina over time, when compared to results from an established commercial OCT device. (See October 28, 2018 press release titled “Acucela Completes PBOS Clinical Study and Validates Concept.”) A commercial OCT ...

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      Mentions: Acucela Kubota
    19. In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography

      In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography

      This study investigates the hyaloid vascular regression and its relationship to the retinal and choroidal vascular developments using optical coherence tomography angiography (OCTA). Normal and oxygen-induced retinopathy (OIR) rat eyes at postnatal day 15, 18, 21, and 24 were longitudinally imaged using OCTA. At each day, two consecutive imaging for visualizing the hyaloid vasculature and the retinal and choroidal vasculatures were conducted. The hyaloid vessel volume and the retinal and choroidal vessel densities were measured. The hyaloid vessel volumes gradually decreased during the regression, although the OIR eyes exhibited large vessel volumes at all time points. A spatial relationship between ...

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    20. Potential Utility Of Foveal Morphology In Preterm Infants Measured Using HAND-HELD Optical Coherence Tomography In Retinopathy Of Prematurity Screening

      Potential Utility Of Foveal Morphology In Preterm Infants Measured Using HAND-HELD Optical Coherence Tomography In Retinopathy Of Prematurity Screening

      Purpose: To investigate dynamic foveal morphology with postmenstrual age, in preterm infants with and without retinopathy of prematurity using hand-held optical coherence tomography, adjusting for gestational age (GA) and birthweight (BW). Methods: Prospective mixed cross-sectional/longitudinal observational study of 87 participants (23–36 weeks GA; n = 30 with, n = 57 without retinopathy of prematurity) using hand-held optical coherence tomography images (n = 278) acquired between 31 weeks and 44 weeks postmenstrual age excluding treated retinopathy of prematurity. Measurements included foveal width, area, depth, central foveal thickness, maximum slope, and parafoveal retinal thickness at 1,000 µm nasal and temporal to the ...

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    21. Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography

      Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography

      Using adaptive optics optical coherence tomography, human photoreceptors and retinal pigment epithelium (RPE) cells are typically visualized on a small field of view of ∼1° to 2°. In addition, volume averaging is required for visualizing the RPE cell mosaic. To increase the imaging area, we introduce a lens based spectral domain AO-OCT system that shows low aberrations within an extended imaging area of 4°×4° while maintaining a high (theoretical) transverse resolution (at >7 mm pupil diameter) in the order of 2 µm. A new concept for wavefront sensing is introduced that uses light mainly originating from the RPE layer ...

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    22. Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease: A Novel Swept-Source Optical Coherence Tomography Analysis

      Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease: A Novel Swept-Source Optical Coherence Tomography Analysis

      Purpose: To report the frequency, optical coherence tomography (OCT) findings, and visual and anatomic outcomes of patients with acute Vogt-Koyanagi-Harada disease (VKH) presenting with bacillary layer detachment (BLD) (intraretinal split at the photoreceptor inner segment myoid). Methods: This was a retrospective analysis of a consecutive series of VKH patients having a minimum follow-up of 6 months. All patients had swept-source (SS)-OCT, fluorescein angiography (FA), and indocyanine green angiography (ICGA) performed at baseline. The characteristics of serial SS-OCT were recorded and analyzed. Results: Sixty-two subjects (42 females; age: 34.2 ± 12 years) with VKH were included. 118 eyes (95.2 ...

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    23. FOVEAL AVASCULAR ZONE VOLUME: A New Index Based on Optical Coherence Tomography Angiography Images

      FOVEAL AVASCULAR ZONE VOLUME: A New Index Based on Optical Coherence Tomography Angiography Images

      Purpose: To propose a new clinical evaluation index, foveal avascular zone (FAZ) volume, and analyze its statistical significance. Methods: A semiautomatic method is proposed to measure the FAZ volume in optical coherence tomography angiography images as follows: The region of interest was flattened and annotated axially. The labeled pixels in the restored region of interest were counted as the FAZ volume. Linear regression and the independent samples t -test were performed for the statistical analysis. Results: Sixty-one normal, 64 high myopia, and 42 diabetic retinopathy eyes were imaged using optical coherence tomography angiography . For normal eyes, the FAZ volume correlates ...

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    24. Longitudinal Follow-up of Tubercular Serpiginous-Like Choroiditis using Optical Coherence Tomography Angiography

      Longitudinal Follow-up of Tubercular Serpiginous-Like Choroiditis using Optical Coherence Tomography Angiography

      Purpose: To analyze and describe serial follow-up of choriocapillaris alterations in tubercular serpiginous like choroiditis (TB SLC) using optical coherence tomography angiography (OCTA) and to compare it with multimodal imaging. Methods: In this prospective cohort study, patients with active TB SLC underwent OCTA using Optovue RTVue XR Avanti® and other imaging including enhanced-depth imaging optical coherence tomography (EDI- OCT ) (Heidelberg Spectralis®), autofluorescence (FAF), fluorescein angiography (FA) and indocyanine green angiography (ICGA). Serial imaging was performed for a total follow-up of 3 months. Choriocapillaris alterations at the site of lesions were analyzed on OCTA imaging and their mean lesion areas (LA ...

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