Category: Ophthalmology

1. OCT Companies in the News

   (415 articles) Carl Zeiss Meditec

   (104 articles) Heidelberg Engineering

   (60 articles) Optovue

   (44 articles) Topcon Medical Systems

   (34 articles) OTI Ophthalmic Technologies Inc.

   (25 articles) Optopol Technology

   (25 articles) Bioptigen

   (13 articles) Bausch & Lomb

   (11 articles) Nidek

   (8 articles) Canon Medical Systems

2. OCT Products in the News

   (269 articles) Zeiss Stratus OCT

   (85 articles) Zeiss Cirrus HD-OCT

   (83 articles) Zeiss Visante OCT

   (62 articles) Heidelberg Spectralis

   (45 articles) Optovue RTVue-100

   (24 articles) Topcon 3D OCT-1000

   (15 articles) Ophthalmic Technologies Spectral OCT/SLO

   (11 articles) Optopol SOCT Copernicus

   (2 articles) Nidek RS-3000

   (1 articles) Tomey SS-1000 Optical Coherence Tomographer

3. Organizations in the News

   (87 articles) Keck School of Medicine

   (69 articles) University of Miami

   (59 articles) Medical University of Vienna

   (59 articles) Duke University

   (56 articles) University of Pittsburgh

   (54 articles) Massachusetts Institute of Technology

   (43 articles) UCSD

   (43 articles) Tufts University

   (40 articles) Johns Hopkins University

   (38 articles) University of Tsukuba

4. People in the News

   (58 articles) Joel S. Schuman

   (48 articles) James G. Fujimoto

   (40 articles) David Huang

   (38 articles) Yoshiaki Yasuno

   (36 articles) Joseph A. Izatt

   (35 articles) Jay S. Duker

   (33 articles) Ursula Schmidt-Erfurth

   (30 articles) Carmen A. Puliafito

   (27 articles) Robert N. Weinreb

   (27 articles) Robert J. Zawadzki

1. Feature Of The Week 3/14/10: Multimodal Imaging with Integrated Photoacoustic Microscopy and Optical Coherence Tomography

   Explore Article Optical Coherence Tomography News (9 hours, 59 min ago) Ophthalmology

   Feature Of The Week 3/14/10: Photoacoustic Ophthalmoscopy (PAOM) is based on Laser-scanning Optical Resolution Photoacoustic Microscopy (LS-OR-PAM), which is a branch of photoacoustic microscopy (PAM). LS-OR-PAM was first developed with the collaboration of Dr. Hao Zhang's lab at University of Wisconsin-Milwaukee and Dr. Shuliang Jiao lab at University of Southern California. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high ...
   

   Comment on Article Mentions:   Shuliang Jiao   University of Wisconsin   Keck School of Medicine

2. A Comparison of Visual Field Sensitivity to Photoreceptor Thickness in Retinitis Pigmentosa

   Explore Article iovs.org (17 hours, 26 min ago) Ophthalmology

   Purpose: To explore the relationship between visual field sensitivity and photoreceptor layer thickness in patients with retinitis pigmentosa (RP). Methods: Static automated perimetry with Humphrey Field Analyzer (central 30-2 threshold program with spot size III) and frequency domain optical coherence tomography (fd-OCT) scans with Spectralis HRA+OCT were obtained from 10 age-matched normal controls and 20 patients with RP retaining good central vision (better than 20/32). The OS+ thickness [the distance between retinal pigment epithelium (RPE)/Bruch's membrane (BM) to the photoreceptor inner-outer segment junction], outer nuclear layer (ONL) and total retinal thickness were measured at locations corresponding to visual field test ...
   

   Comment on Article Mentions:   Heidelberg Spectralis   Columbia University   Heidelberg Engineering

3. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats

   Explore Article ScienceDirect (17 hours, 32 min ago) Neurology , Ophthalmology

   Purpose To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants. Methods Donor retinal sheets were isolated from E19 fetuses of transgenic rats expressing human alkaline phosphatase (hPAP), and transplanted to the subretinal space of 19–56 days old S334ter-3 rat recipients with fast retinal degeneration (average age at surgery 32 days). A total of 143 rats were imaged 1 day to 2.8 months after surgery, using a Fourier-domain optical coherence tomography (FDOCT) system, with an axial resolution of 3.5 μm. The CCD A-line integration time was set at 200 μs ...
   

   Comment on Article Mentions:   Zhongping Chen   UC Irvine

4. Fundus Autofluorescence, Optical Coherence Tomography, and Electroretinogram Findings in Choroidal Sclerosis

   Explore Article LWW Online (17 hours, 54 min ago) Ophthalmology

   Purpose: The purpose of this study was to describe fundus autofluorescence (FAF), optical coherence tomography, and electroretinogram findings in choroidal sclerosis. Methods: This is a retrospective case series. Eight eyes of four patients with choroidal sclerosis were evaluated with FAF, optical coherence tomography, and electroretinogram testing. Results: In all eight eyes, FAF imaging showed hypofluorescent placoid lesions corresponding to areas of chorioretinal atrophy seen on stereo biomicroscopy. Prominent hyperfluorescent linear markings underlying regions of atrophic disease were observed in all eyes, likely representative of normal choroidal vessel autofluorescence. In two eyes, FAF showed punctate hypofluorescent lesions in the fovea that ...
   

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5. Optical coherence tomography in diabetic macular edema

   Explore Article LWW Online (17 hours, 58 min ago) Ophthalmology

   Purpose of review: Because optical coherence tomography (OCT) has developed quite rapidly in recent years, the purpose of this review is to synthesize much of the recent literature on the use of OCT in the diagnosis and management of diabetic macular edema (DME). Recent findings: OCT has become increasingly utilized in clinical management and in research protocols in the approach to DME. Spectral domain OCT has given clinicians and researchers an even greater pathophysiologic understanding of DME. Summary: OCT has now added another quantitative dimension in the assessment of DME and could lead to better visual outcomes via earlier detection ...
   

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6. Can preoperative anterior chamber angle width predict magnitude of intraocular pressure change after cataract surgery?

   Explore Article NRC Research Press Publishing Services (Mar 13 2010) Ophthalmology

   Objective: To determine whether preoperative anterior chamber angle width, captured by anterior segment optical coherence tomography (AS-OCT), can be a predictor of intraocular pressure (IOP) change following cataract surgery. Design: Prospective comparative observational study. Participants: Fifty-three eyes of 53 patients awaiting cataract surgery were included. Methods: Measurement of anterior chamber angle width and IOP using AS-OCT and Goldmann’s applanation tonometry, respectively, were performed before and 6 months after phacoemulsification and intraocular lens implantation. Preoperative and postoperative measurements were compared using paired t test. The prediction rule defined success as ≥20% IOP reduction from the baseline preoperative IOP measurement. Multivariate regression ...
   

   Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Visante OCT

7. Ultra-high speed full range complex spectral domain optical coherence tomography for volumetric imaging at 140,000 A scans per second

   Explore Article SPIE Digital Library (Mar 11 2010) Ophthalmology

   We demonstrate an ultra-high speed full rang spectral domain optical coherence tomography system based on CMOS camera at 140,000 A-scans per second. By implementing beam-offset method, a constant modulation frequency is introduced into each B-scan that enables the reconstruction of the full range complex SDOCT images from in vivo biological specimens. To make use of the full acquisition capacity of detection camera used in the system, we developed system control software that streams the raw spectral fringe data directly into the computer memory. The feasibly of our high speed full range SDOCT system is demonstrated for imaging the dynamics of ...
   

   Comment on Article Mentions:   Ruikang K. Wang   Lin An   Oregon Health & Science University

8. Correlation Between Morphologic Features on Spectral-Domain Optical Coherence Tomography and Angiographic Leakage Patterns in Macular Edema

   Explore Article LWW Online (Mar 11 2010) Ophthalmology

   Purpose: The purpose of this study was to determine the morphologic patterns of angiographic macular edema using simultaneous colocalization of fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic and pseudophakic cystoid macular edema, and vein occlusion. Methods: Eighty-seven consecutive patients (107 eyes) with macular edema from 5 different etiologies were imaged by simultaneous scanning laser ophthalmoscopy/OCT to study the morphologic patterns of edema on SD-OCT and then correlated/colocalized with the fluorescein angiographic patterns of leakage. Statistical analysis was done to analyze the differences in the morphologic OCT pattern by different diseases. Results: Spectral-domain OCT ...
   

   Comment on Article Mentions:   UCSD   Francesca Mojana   Igor Kozak

9. High Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration

   Explore Article iovs.org (Mar 11 2010) Ophthalmology

   Purpose: To investigate to use of high resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVM) associated with exudative age-related macular degeneration (eAMD). Methods: An Fd-OCT instrument with axial resolution of 4 to 4.5 µm and transverse resolution of 10 to 15 µm was used to image 21 eyes (19 subjects) with newly-diagnosed eAMD. A raster series of 100 B-scans separated by 60 µm was used study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed 3-dimensional macular volume. Results: A highly reflective subretinal ...
   

   Comment on Article Mentions:   UC Davis   Robert J. Zawadzki   Susanna S. Park

10. Early trabeculectomy bleb walls on anterior-segment optical coherence tomography

    Explore Article SpringerLink Home (Mar 11 2010) Ophthalmology

    Background To correlate the cross-sectional features of filtering blebs on anterior-segment optical coherence tomography (AS-OCT) 2 weeks after trabeculectomy with bleb function at 6 months. Methods Forty-eight eyes followed for 6 months or more after trabeculectomy with mitomycin C were included. Bleb wall reflectivity of developing blebs on AS-OCT 2 weeks postoperatively was correlated with mature bleb function at 6-month postoperative visit. Results Developing bleb walls at 2 weeks were classified as uniform in 10/48 eyes (20.8%) and multiform in 38/48 eyes (79.2%). Blebs with uniform reflectivity were significantly more likely to have worse function at 6 months (P < 0.001). Multiform ...
    

    Comment on Article Mentions:   Kyoto University Graduate School of Medicine   Masanori Hangai   Nagahisa Yoshimura

11. MP learns about key issues for people with sight loss

    Explore Article politics.co.uk (Mar 11 2010) Ophthalmology

    At a recent Parliamentary reception, Andrew Miller, MP for Ellesmere Port and Neston, met blind and partially sighted campaigners who are working at local level to secure a better deal for people with sight loss. The event celebrated the work of the cross-party parliamentary group on Eye Health and Visual Impairment, which meets to raise parliamentarians' awareness of issues affecting people with sight loss and on prevention of sight loss. Andrew Miller said "On average around 3,000 people in every parliamentary constituency have sight loss. This was an excellent opportunity for me to learn about the equipment available to people ...
    

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12. Comparison of optic nerve head topography findings in eyes with non-arteritic anterior ischemic optic neuropathy and eyes with glaucoma

    Explore Article SpringerLink Home (Mar 10 2010) Ophthalmology

    Abstract Background  To compare the peripapillary retinal nerve fiber layer (RNFL) thickness in eyes affected by non-arteritic ischemic optic neuropathy (NAION) or glaucoma as determined by optical coherence tomography (OCT). Methods  This cross-sectional institutional study included 18 eyes with NAION (at least 6 months since the acute event) and 29 eyes with glaucoma, both having localized visual field (VF) defects confined to one hemifield. Twenty-nine normal subjects served as controls. The fast RNFL thickness protocol (3.4) of the Stratus OCT (Carl Zeiss Meditec, Dublin, CA, USA) was used. The RNFL thickness and inferior maximum/temporal average (Imax/Tavg) and superior maximum/temporal average (Smax/Tavg) data corresponding ...
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

13. 3D reconstruction of the optic nerve head using stereo fundus images for computer-aided diagnosis of glaucoma

    Explore Article SPIE Digital Library (Mar 9 2010) Ophthalmology

    The shape of the optic nerve head (ONH) is reconstructed automatically using stereo fundus color images by a robust stereo matching algorithm, which is needed for a quantitative estimate of the amount of nerve fiber loss for patients with glaucoma. Compared to natural scene stereo, fundus images are noisy because of the limits on illumination conditions and imperfections of the optics of the eye, posing challenges to conventional stereo matching approaches. In this paper, multi scale pixel feature vectors which are robust to noise are formulated using a combination of both pixel intensity and gradient features in scale space. Feature ...
    

    Comment on Article Mentions:   Michael D. Abramoff   Young H. Kwon   Kyungmoo Lee

14. 3-D segmentation of retinal blood vessels in spectral-domain OCT volumes of the optic nerve head

    Explore Article SPIE Digital Library (Mar 9 2010) Ophthalmology

    Segmentation of retinal blood vessels can provide important information for detecting and tracking retinal vascular diseases including diabetic retinopathy, arterial hypertension, arteriosclerosis and retinopathy of prematurity (ROP). Many studies on 2-D segmentation of retinal blood vessels from a variety of medical images have been performed. However, 3-D segmentation of retinal blood vessels from spectral-domain optical coherence tomography (OCT) volumes, which is capable of providing geometrically accurate vessel models, to the best of our knowledge, has not been previously studied. The purpose of this study is to develop and evaluate a method that can automatically detect 3-D retinal blood vessels from ...
    

    Comment on Article Mentions:   Michael D. Abramoff   Kyungmoo Lee   University of Iowa

15. Automated 3D segmentation of intraretinal layers from optic nerve head optical coherence tomography images

    Explore Article SPIE Digital Library (Mar 9 2010) Ophthalmology

    Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast use in the diagnosis and management of ocular diseases such as glaucoma, where the retinal nerve fiber layer (RNFL) has been known to thin. Furthermore, the recent availability of the considerably larger volumetric data with spectral-domain OCT has increased the need for new processing techniques. In this paper, we present an automated 3-D graph-theoretic approach for the segmentation of 7 surfaces (6 layers) of the retina from 3-D spectral-domain OCT images centered on the optic nerve head (ONH). The multiple surfaces are detected simultaneously through the ...
    

    Comment on Article Mentions:   Michael D. Abramoff   Kyungmoo Lee   University of Iowa

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