Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. A New Paradigm for Glaucoma Diagnosis - Video By Dr. Joel S. Schuman, MD, FACS
  
  Explore Blogs – UPMC Physician Resources Mar 10 2014 Ophthalmology
  
  Glaucoma is the world’s second leading cause of blindness. In recognition of that, the World Glaucoma Association has named March 9-15 World Glaucoma Week. This is a week dedicated to encouraging everyone to find out if they are at risk. Joel S. Schuman, MD, FACS, and his team have been working on a way to diagnose glaucoma earlier. Dr. Schuman’s team has been using Optical Coherence Tomography (OCT) to detect early abnormalities in the optic nerve that occur before the change is detectable in the vision field. This development enables ophthalmologists to diagnose glaucoma earlier than ever before ...
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  Mentions: University of Pittsburgh Joel S. Schuman
2. Metastatic carcinoma to the vitreous: an optical coherence tomography and ultrawide field imaging study
  
  Explore Wiley Online Library Mar 10 2014 Ophthalmology
  
  Letter to the Editor
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  Comment
  
  Mentions: Nagahisa Yoshimura Kyoto University Graduate School of Medicine
3. Congenital simple hamartoma of the retinal pigment epithelium: clinical, optical coherence tomography, and histopathological correlation
  
  Explore Nature Publishing Group Mar 10 2014 Ophthalmology
  
  Correspondence
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  Mentions: Jay S. Duker Tufts University
4. Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography
  
  Explore SPIE | Journal Mar 10 2014 Ophthalmology
  
  In this study, polarization-sensitive optical coherence tomography (PS-OCT) capable of providing polarization contrasts such as phase retardation and degree of polarization uniformity (DOPU) was used for visualizing human meibomian glands (MGs) and investigating morphological characteristics of them. Especially, with the help of the DOPU contrast, MGs were exclusively extracted from the volumetric OCT image. In vivo PS-OCT measurements were performed on the upper eyelids of different age groups. From these measurements, different age-dependent aspects of the MG structure were also observed. Based on these observations, it can be inferred that the PS-OCT system has the potential for clinical diagnosis and ...
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  Mentions: Yoshiaki Yasuno Byeong Ha Lee University of British Columbia
5. Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography
  
  Explore SPIE | Journal Mar 10 2014 Neurology , Ophthalmology
  
  An intraoperative surgical microscope is an essential tool in a neuro- or ophthalmological surgical environment. Yet, it has an inherent limitation to classify subsurface information because it only provides the surface images. To compensate for and assist in this problem, combining the surgical microscope with optical coherence tomography (OCT) has been adapted. We developed a real-time virtual intraoperative surgical OCT (VISOCT) system by adapting a spectral-domain OCT scanner with a commercial surgical microscope. Thanks to our custom-made beam splitting and image display subsystems, the OCT images and microscopic images are simultaneously visualized through an ocular lens or the eyepiece of ...
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  Mentions: University of Ulsan Jeehyun Kim Changho Lee
6. Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
  
  Explore opticsinfobase.org Mar 10 2014 Ophthalmology
  
  We demonstrate the repeatability of lamina cribrosa (LC) microarchitecture for in vivo 3D optical coherence tomography (OCT) scans of healthy, glaucoma suspects, and glaucomatous eyes. Eyes underwent two scans using a prototype adaptive optics spectral domain OCT (AO-SDOCT) device from which LC microarchitecture was semi-automatically segmented. LC segmentations were used to quantify pore and beam structure through several global microarchitecture parameters. Repeatability of LC microarchitecture was assessed qualitatively and quantitatively by calculating parameter imprecision. For all but one parameters (pore volume) measurement imprecision was <4.7% of the mean value, indicating good measurement reproducibility. Imprecision ranged between 27.3% and ...
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  Mentions: University of Pittsburgh Joel S. Schuman Larry Kagemann
7. Development of a widefield phantom eye for retinal optical coherence tomography
  
  Explore Conference Proceedings Mar 8 2014 Ophthalmology
  
  We report the design, manufacture and assessment of a phantom eye that can be used to measure the performance and accuracy of ophthalmic-OCT devices. We base our design on a wide-field schematic eye, R. Navarro, J. Opt. Soc. Am. A 2 (1985), to allow the assessment of device performance relative to ± 70° external field of view. We have fabricated the phantom eye and have verified the structural dimensions of the multi-material 3D-printed retinal targets using calibrated-OCT images.
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  Mentions: Optos
8. Detection of retinal nerve fiber layer degeneration in patients with Alzheimer's disease using optical coherence tomography: searching new biomarker
  
  Explore Wiley Online Library Mar 8 2014 Neurology , Ophthalmology
  
  Letter to the Editor.
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  Mentions: Miguel Servet University Hospital Luis E. Pablo
9. Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT
  
  Explore iovs.org Mar 8 2014 Ophthalmology
  
  Purpose:The goal was to assess effects of intraocular pressure (IOP) and pilocarpine-induced ciliary muscle contraction on conventional outflow pathway tissues in living anesthetized mice. Methods:IOP was controlled by intracameral cannulation of mouse eyes while imaging using spectral domain optical coherence tomography (SD-OCT). Time-lapse sagittal SD-OCT sections through Schlemm's canal (SC) were acquired while changing IOP stepwise between 10 and 45 mmHg. After topical application of 1% pilocarpine, the series of IOP steps and imaging were repeated. Effects of pilocarpine on IOP and outflow facility in living mice were verified by rebound tonometry and flow measurements at 3 ...
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  Mentions: Imperial College London Duke University Sina Farsiu
10. Quantitative Assessment of Retinal Nerve Fiber Layer Defect Depth Using Spectral-Domain Optical Coherence Tomography
  
  Explore Ophthalmology Mar 6 2014 Ophthalmology
  
  Purpose To assess quantitatively the depth of retinal nerve fiber layer (RNFL) defects using a Cirrus high-definition (HD) optical coherence tomography (OCT)–derived RNFL thickness deviation map. Design Prospective, cross-sectional study. Participants Three-hundred fifteen eyes with localized and diffuse RNFL defects of 315 glaucoma patients and 217 eyes of 217 healthy subjects. Methods For the glaucoma subjects, the severity of the RNFL defect was graded on red-free fundus photographs by 2 observers using a standardized protocol with a 3-level grading system. The RNFL defect depth on the RNFL thickness deviation map was expressed as an RNFL defect depth percentage index ...
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  Mentions: Seoul National University
11. Five-dimensional analysis of multi-contrast Jones matrix tomography of posterior eye
  
  Explore Conference Proceedings Mar 6 2014 Ophthalmology , Velocimetry
  
  Pixel clustering algorithm tailored to multi-contrast Jones matrix based optical coherence tomography (MC-JMT) is demonstrated. This algorithm clusters multiple pixels of MC-JMT in a five-dimensional (5-D) feature space which comprises dimensions of lateral space, axial space, logarithmic scattering OCT intensity, squared power of Doppler shift and degree of polarization uniformity. This 5-D clustering provides clusters of pixels, so called as superpixels. The superpixels are utilized as local regions for pixels averaging. The averaging decreases the noise in the measurement as preserving structural details of the sample. A simple decision-tree algorithm is applied to classified superpixels into some tissue types. This ...
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  Mentions: Yoshiaki Yasuno Masahiro Miura University of Tsukuba
12. Influence of automated disc margin determination on Stratus OCT optic nerve head measurements
  
  Explore Medical Journals Publisher Mar 5 2014 Ophthalmology
  
  Purpose: To analyze the influence of manual correction of the automatically determined edge of the optic nerve head (ONH) in optic disc measurements in cases in which the optical coherence tomography did not identify the disc limits correctly. Methods: The study included 127 eyes from 127 consecutive patients with glaucoma, suspects, and healthy individuals. In a retrospective analysis, eyes that underwent testing with the Stratus OCT (software version 4.0, Carl Zeiss Meditec, Dublin, CA, USA) Fast Optic Disc protocol were evaluated. Forty-seven eyes in which either the manual assignment was not necessary or the signal strength was below six ...
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  Mentions: University of São Paulo Carl Zeiss Meditec Zeiss Stratus OCT
13. Long-term results of intravitreal ranibizumab for the treatment of retinal angiomatous proliferation and utility of an advanced RPE analysis performed using spectral-domain optical coherence tomography
  
  Explore BJO Online Mar 5 2014 Ophthalmology
  
  Purpose To report the results of 3-year follow-up examinations after intravitreal ranibizumab (IVR) injection for the treatment of retinal angiomatous proliferation (RAP) and to examine the utility of an advanced retinal pigment epithelium (RPE) analysis performed using spectral-domain optical coherence tomography (SD-OCT). Methods We retrospectively reviewed 17 treatment-naïve eyes in 14 patients (4 men, 10 women; age range 71–87 years; mean age 80 years) treated with IVR. All the patients received three consecutive monthly injections of 0.5 mg/0.05 mL of ranibizumab as an induction treatment. Retreatment was allowed if evidence of clinical deterioration was noted ...
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14. Optical coherence tomography imaging of ocular and periocular tumours
  
  Explore BJO Online Mar 5 2014 Oncology , Ophthalmology
  
  Optical coherence tomography (OCT) has become pivotal in the practice of ophthalmology. Similar to other ophthalmic subspecialties, ophthalmic oncology has also incorporated OCT into practice. Anterior segment OCT (AS-OCT), ultra-high resolution OCT (UHR-OCT), spectral domain OCT (SD-OCT) and enhanced depth imaging OCT (EDI-OCT), have all been described to be helpful in the diagnosis, treatment planning and monitoring response of ocular and periocular tumours. Herein we discuss the role of OCT including the advantages and limitations of its use in the setting of common intraocular and adnexal tumours.
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  Mentions: Cleveland Clinic
15. Response: Optical coherence tomography of the suprachoroid after CyPass Micro-Stent implantation for the treatment of open angle glaucoma
  
  Explore BJO Online Mar 5 2014 Ophthalmology
  
  In the recently published article, Saheb et al 1 evaluated changes to the anatomy of the supraciliary space with anterior segment optical coherence tomography imaging after CyPass Micro-Stent implantation
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  Mentions: University of Alabama
16. Duke University Receives NIH Grant for Studying Coherent Light Scattering for Early Detection of Retinal Disease
  
  Explore Optical Coherence Tomography News Mar 4 2014 Ophthalmology , Funding
  
  Duke University Received a 2014 NIH Grant for $189,624 for Studying Coherent Light Scattering for Early Detection of Retinal Disease. The principal investigator was Adam Wax. The program began in 2013 and ends in 2015. Below is a summary of the proposed work. The overall objective of this proposal is to develop a novel in vivo optical imaging system that will quantify structural biomarkers of retinal degenerative diseases. The state-of-the-art technology is measurement of the thickness of retina layers by spectral domain optical coherence tomography (SDOCT). However, while SDOCT can resolve histological layers, it lacks the resolution to measure ...
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  Mentions: National Institutes of Health Duke University Adam Wax
17. Comparison of relation between visual function index and retinal nerve fiber layer structure by optical coherence tomography among primary open angle glaucoma and primary angle closure glaucoma eyes
  
  Explore Oman Journal of Ophthalmology Mar 4 2014 Ophthalmology
  
  Purpose: To compare the visual field index (VFI) in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) eyes, and to study the correlation with disc variables on optical coherence tomography (OCT) in all stages of severity. Materials and Methods: Thirty POAG and PACG underwent Humphrey visual field 24-2 along with detailed examination. They also underwent stratus OCT imaging of the optic nerve and retinal nerve fiber layer (RNFL). The correlation of VFI with RNFL thickness was compared in POAG and PACG. Results: The VFI significantly differed between POAG and PACG, with POAG eyes apparently having a better ...
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  Mentions: Zeiss Stratus OCT
18. Optical Coherence Tomography (Textbook)
  
  Explore Karger Publishers Mar 4 2014 Ophthalmology , Textbooks
  
  Because of its many advantages optical coherence tomography (OCT) has revolutionized the way in which retinal diseases are screened and managed and how treatments are monitored. In this volume the latest developments and findings are presented by experts in their respective fields. After a short introduction covering the available equipment and the basic techniques, the imaging features of various pathological findings in retinal diseases are presented. The topics cover the outer layers including new modalities for choroid imaging, out-layer diseases such as the various types of macular degeneration, retinal diseases such as diabetic retinopathy and vascular occlusion, and retina and ...
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  Mentions: Gabriel J. Coscas Centre Hospitalier Intercommunal de Créteil Francesco Bandello
19. Towards femtosecond laser surgery guidance in the posterior eye: utilization of optical coherence tomography and adaptive optics for focus positioning and shaping
  
  Explore Conference Proceedings Mar 4 2014 Ophthalmology
  
  Although fs-laser surgery is clinically established in the field of corneal flap cutting for laser in situ keratomileusis, surgery with fs-laser in the posterior part of the eye is impaired by focus degradation due to aberrations. Precise targeting and keeping of safety distance to the retina also relies on an intraoperative depth resolved imaging. We demonstrate a concept for image guided fs-laser surgery in the vitreous body combining adaptive optics (AO) for focus reshaping and optical coherence tomography (OCT) for focus position guidance. The setup of the laboratory system consist of an 800 nm fs-laser which is focused into a ...
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  Mentions: Alexander Krüger Laser Zentrum Hannover
20. Intraoperative Corneal Thickness Measurement by Optical Coherence Tomography in Keratoconic Patients Undergoing Corneal Collagen Cross-Linking
  
  Explore American Journal of Ophthalmology Mar 4 2014 Ophthalmology
  
  Purpose To assess intra-operative variation of corneal thinnest point in keratoconic patients undergoing riboflavin/UV-A (Ultraviolet type A) cross-linking treatment using non-contact time domain optical pachymetry. Design Prospective, non-comparative, Interventional Study. Methods 10 patients underwent epithelium-off riboflavin/Ultraviolet type A corneal cross-linking at Siena University Hospital; corneal thickness was measured by using the Visante™ Optical Coherence Tomography (Zeiss, Jena, Germany) at the following times: preoperatively with epithelium-on, after removal of an 9-mm diameter disc of epithelium, immediately after instillation of two drops of riboflavin 0.1%, dextran T 500 20% solution, after repeated instillation of riboflavin 0.1%, dextran T ...
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  Mentions: Carl Zeiss Meditec Zeiss Visante OCT
21. Multiple-object geometric deformable model for segmentation of macular OCT
  
  Explore opticsinfobase.org Mar 4 2014 Ophthalmology
  
  Optical coherence tomography (OCT) is the de facto standard imaging modality for ophthalmological assessment of retinal eye disease, and is of increasing importance in the study of neurological disorders. Quantification of the thicknesses of various retinal layers within the macular cube provides unique diagnostic insights for many diseases, but the capability for automatic segmentation and quantification remains quite limited. While manual segmentation has been used for many scientific studies, it is extremely time consuming and is subject to intra- and inter-rater variation. This paper presents a new computational domain, referred to as flat space, and a segmentation method for specific ...
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  Mentions: Peter A. Calabresi Johns Hopkins University
22. En Face OCT Imaging of the Eye - Special Interest Group for the 2014 ARVO Annual Meeting May 2014
  
  Explore Optical Coherence Tomography News Mar 3 2014 Ophthalmology
  
  The Association for Research in Vision and Ophthalmology (ARVO)has approved a new Special Interest Group (SIG) for the 2014 ARVO Annual Meeting, May 4-8, 2014, in Orlando, Florida. The SIG is titled: En Face OCT imaging of the Eye – SIG, Session Number: 355. The Organizer is Andre Romano and includes the following speakers: David Huang, James Fujimoto, Philip Rosenfeld. Bruno Lumbroso, Gabriel Coscas, Min Wang, Richard Rosen. More can be found by clicking HERE .
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  Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto
23. Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis?
  
  Explore Multiple Sclerosis Mar 3 2014 Neurology , Ophthalmology
  
  Objective: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS). Methods: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0–4 conventional score. Results: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes ( p =0.11), 68% and 86% in eyes with previous ON ( p =0.12), and in 19% versus 40% in eyes ...
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  Mentions: San Raffaele Scientfic Institute
24. Optimising deep anterior lamellar keratoplasty (DALK) using intraoperative online optical coherence tomography (iOCT)
  
  Explore BJO Online Mar 3 2014 Ophthalmology
  
  Background/aims To describe the use of intraoperative online optical coherence tomography (iOCT) for improving deep anterior lamellar keratoplasty (DALK) surgery. Methods Retrospective case series of 6 eyes of 6 male patients with keratokonus, corneal dystrophy or herpetic stromal scars undergoing DALK were investigated using intraoperative optical coherence tomography and postsurgical image/video analysis. Main outcome measures were: visibility of surgical steps, especially, assessment of placement depth of injection needle, preparation of bare Descemet's membrane and drainage of interface fluid. Results iOCT enables real-time visualisation of all surgical steps of DALK procedure in all patients. Placement of air injection ...
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  Mentions: University of Cologne Gereon Hüttmann University of Lübeck
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