Category: Ophthalmology

Bioptigen Press Release - Devices become first OCT systems cleared for hand-held ophthalmic imaging of children Bioptigen Inc. has received 510(k) clearance from the U.S. Food and Drug Administration to begin marketing its hand-held Envisu Spectral Domain Ophthalmic Imaging System (SDOIS) devices for patient use. The Envisu SDOIS aids in the diagnosis of physiological and pathological conditions of the eye through non-contact optical imaging. In receiving this regulatory clearance, Bioptigen’s Envisu SDOIS become the first optical coherence tomography imaging systems commercially available in the United States for hand-held and pediatric imaging. Envisu’s ergonomic, hand-held scanner enables imaging ...

Pigmented paravenous retinochoroidal atrophy (PPRCA) is a rare disease characterized by bilateral retinochoroidal atrophy and pigmentation along the retinal veins. The authors describe spectral-domain optical coherence tomography (SD-OCT) in a case of PPRCA. The right macula showed a lamellar macular hole. In addition, scans were taken through the affected areas along the retinal veins that revealed the location of the pigment and other features. These findings have not been reported previously.

BACKGROUND AND OBJECTIVE: To evaluate choroidal thickness at five macular locations and assess the correlations between choroidal thickness at these locations with age, refractive error, and axial length. PATIENTS AND METHODS: Eighty-four eyes from 42 healthy adult volunteers were included. Enhanced depth imaging by spectral-domain optical coherence tomography was performed, and choroidal thickness was measured at five macular locations: subfoveal and 3 mm nasal, temporal, superior, and inferior. Correlations of choroidal thickness at each location with age, refractive error, and axial length were analyzed. RESULTS: Mean choroidal thicknesses at the subfoveal, superior, inferior, temporal, and nasal locations were 293, 308 ...

Objective and Aim. In routine clinical practice, laser methods for the evaluation of optic disc parameters are expensive and not accessible for all ophthalmologists; therefore, there is a need for less expensive technique. The aim of this study was to assess correlations between the parameters of the optic disc measured by digital planimetry (DP), optical coherence tomography (OCT), and confocal scanning laser ophthalmoscopy (CSLO) in healthy and glaucoma patients with the normal biometric parameters of the eye. Material and Methods. This case-control study enrolled 40 patients with glaucoma and 32 healthy patients with the normal biometric parameters of the eye ...

BACKGROUND: We have recently developed a microscope-integrated spectral-domain optical coherence tomography (MIOCT) device towards intrasurgical cross-sectional imaging of surgical maneuvers. In this report, we explore the capability of MIOCT to acquire real-time video imaging of vitreoretinal surgical maneuvers without post-processing modifications. METHODS: Standard 3-port vitrectomy was performed in human during scheduled surgery as well as in cadaveric porcine eyes. MIOCT imaging of human subjects was performed in healthy normal volunteers and intraoperatively at a normal pause immediately following surgical manipulations, under an Institutional Review Board-approved protocol, with informed consent from all subjects. Video MIOCT imaging of live surgical manipulations was ...

Purpose: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tomography (SDOCT) hyperreflective foci in eyes with non-advanced AMD. Methods: A prospective cross-sectional analysis of 314 eyes (314 subjects) with intermediate AMD was performed in the multicenter AREDS2 Ancillary SDOCT Study to correlate hyperpigmentary changes on color fundus photographs (CFP) with abnormal morphology on SDOCT. Spatial coregistration was performed with an automated algorithm in 2 non-overlapping subsets of 20 study eyes with double-masked CFP and SDOCT grading by certified ...

Objective: To compare retinal nerve fiber layer (RNFL) and macular thickness measurements in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO) with or without history of optic neuritis and in controls using Fourier-domain (FD) optical coherence tomography (OCT). Methods: Patients with MS (n=60), NMO (n=33), longitudinal extensive transverse myelitis (LETM) (n=28) and healthy controls (n=41) were submitted to ophthalmic examination, including automated perimetry, and to FD-OCT RNFL and macular thickness measurements. Five groups of eyes were compared: MS with or without previous optic neuritis, NMO, LETM and controls. Correlation between OCT and visual field (VF ...

PURPOSE. To retrospectively evaluate the morphologic choroidal and scleral characteristics in eyes with pathologic myopia using high-penetration optical coherence tomography (HP-OCT). METHODS. The subfoveal choroidal and scleral thicknesses were measured using the prototype HP-OCT with a 1,060-nm light source. We also measured the scleral thickness 3 mm superior, inferior, nasal, and temporal to the fovea on the horizontal and vertical OCT sections. The axial length (AL) in all eyes was measured using optical biometry. RESULTS. Fifty-eight eyes of 35 patients (7 men, 28 women; mean age, 65.5 years) with an AL exceeding 26.5-mm were examined. The mean ...

Objective To evaluate 3D spectral domain optical coherence tomography (SDOCT) volume scans as a tool for quantification of optic nerve head (ONH) volume as a potential marker for treatment effectiveness and disease progression in idiopathic intracranial hypertension (IIH). Design and Patients Cross-sectional pilot trial comparing 19 IIH patients and controls matched for gender, age and body mass index. Each participant underwent SDOCT. A custom segmentation algorithm was developed to quantify ONH volume (ONHV) and height (ONHH) in 3D volume scans. Results Whereas peripapillary retinal nerve fiber layer thickness did not show differences between controls and IIH patients, the newly developed ...

A novel technique for axial resolution improvement in Fourier domain optical coherence tomography (FDOCT) is presented. The technique is based on the deconvolution of modulated optical coherence tomography signals. In FDOCT, the real part of the Fourier transform of the interferogram is modulated by a frequency which depends on the position of the interferogram in k space. A slight numerical k shift results in a different modulation frequency. By adding two shifted signals, beating can appear in the A-scan. When the amount of shifting is appropriately selected, deconvolution of the resulting depth profile, using suitable modulated kernels, yields a narrower ...

The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.

Aims To examine the rate of macular thickness loss using time-domain optical coherence tomography (OCT) in functionally progressing versus non-progressing eyes, determined by standard automated perimetry (SAP). Methods Glaucoma suspects (GS) and glaucomatous (G) eyes underwent SAP and OCT imaging every 6 months. Functional progression was determined using pointwise linear regression, defined as 2 contiguous locations losing ≥1.0 dB/year at P<1.0% in the same hemifield. The annual rate of macular thickness loss was calculated from inner and outer regions of the macular map. Results 72 eyes (43 GS and 29G) with ≥30 months of follow-up were enroled. Fourteen eyes demonstrated SAP progression. The annual rate of macular thickness loss (μm/year) in progressing eyes was faster (all P<0.05) than non-progressing eyes in temporal outer (−1.90±2.97 vs 0.33±2.77), nasal inner (−1.70±2.66 vs 0.14±2.76), superior inner (−2.15±4.57 vs 0.51±2.99), temporal inner quadrants (−2.58±5.05 vs −0.38±2.34), and the average of inner macular quadrants (−1.84±2.90 vs 0.03±2.10). The rate of loss in the nasal inner (P=0.02) and temporal outer (P=0.02) macular regions was associated with optic disc haemorrhage. Conclusions Eyes with SAP progression have significantly greater rates of macular thickness loss consistent with glaucomatous retinal ganglion cell atrophy, as compared with non-progressing eyes.

Background To evaluate the clinical efficacy of ring-shaped corneoscleral lamellar keratoplasty under guidance of highdefinition optical coherence tomography (HD-OCT) and Scheimpflug imaging for severe Terrien ’s marginal corneal degeneration. Methods Twenty-five patients (25 eyes) with Terrien's marginal corneal degeneration and ≥6 diopters of astigmatism were treated at the Shandong Eye Institute from January 2008 through December 2010. In these patients, the diseased area was>1 quarter of the cornea, and the thickness at the thinnest corneal area was

Idopathic scherochoroidal calcification (SCC) is a rare, benign condition occurring in middle-aged and elderly adults without systemic findings.

Purpose To evaluate the effects of ocular rotation on parapapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT). Patients and methods Eighty-eight normal and 205 glaucomatous eyes were studied. RNFL thickness was measured by 3D OCT. Ocular rotation angle was measured from a fundus image obtained by a non-mydriatic fundus camera equipped with 3D OCT. The average, hemi-superior, and hemi-inferior RNFL thicknesses as well as those in the 4 quadrants and the 16-segmented superotemporal (ST-1) and inferotemporal (IT-4) sectors were compared both before and after correcting for ocular rotation. Receiver operating characteristic curves and the ...