Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
  
  Explore iovs.org 3 hours, 30 min ago Ophthalmology
  
  Purpose: Lamina cribrosa (LC) is a leading location of glaucomatous damage. The purpose of this study is to compare LC 3-dimensional microarchitecture between healthy and glaucomatous eyes in-vivo using optical coherence tomography (OCT). Methods: Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47 subjects were scanned in a 3.5x3.5x3.64mm volume (400x400x896 pixels) at the optic nerve head using swept-source OCT. The LC microarchitecture parameters were measured on the visible LC by an automated segmentation algorithm. The LC parameters were compared to diagnosis and visual field mean deviation (MD) using a linear mixed effects model accounting for age ...
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  Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto
2. Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis
  
  Explore Optical Coherence Tomography News 20 hours, 49 min ago Ophthalmology , Jobs & Studentships
  
  Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis. One position will be filled by someone with background in vision science while the other will be for a person with experience in a high-resolution imaging modality such as OCT, adaptive optics or scanning laser ophthalmoscope. Strong skills in programming or image processing would be an asset. The positions will be open until filled. Salary will be based on experience and salary scales of the UC. The University of California is committed to diversity. Minorities, women, veterans and persons ...
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  Mentions: John S. Werner UC Davis
3. Ultra-widefield imaging may improve ability to diagnose, monitor, treat
  
  Explore Healio.com Dec 3 2013 Ophthalmology
  
  Ultra-widefield retinal imaging is a viable option that may improve the efficiency of diagnostics for diabetic retinopathy and diabetic macular edema, according to one specialist. Standard methods for assessment and follow-up of DR and DME have included fluorescein angiography, fundus photography and optical coherence tomography. However, novel ultra-widefield (UWF) scanning laser technology ( Optos ) allows wide-angle visualization that includes peripheral areas of the retina ...
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  Mentions: Optos
4. Epiretinal Membranes in Patients with Uveitis: Morphological and Functional Analysis with Spectral Domain Optical Coherence Tomography
  
  Explore Hindawi Publishing Corporation Dec 3 2013 Ophthalmology
  
  Purpose . To correlate the uveitic epiretinal membrane (ERM) features using spectral-domain optical coherence tomography (SD-OCT) with visual acuity (VA). Methods . Forty-one eyes of 32 patients were included in this retrospective study. SD-OCT was performed in all patients and data were collected at the time of ERM diagnosis and at the final visit. Both best corrected visual acuity (BCVA) and ERM thickness were correlated with the morphological and clinical features. Results . Final BCVA was positively correlated with male sex and the focal pattern of ERM attachment and negatively correlated with IS/OS photoreceptor junction disruption . BVCA change showed a positive correlation ...
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  Mentions: Heidelberg Engineering Heidelberg Spectralis Sapienza University of Rome
5. Can optical coherence tomography replace fluorescein angiography in detection of ischemic diabetic maculopathy?
  
  Explore Home - Springer Dec 3 2013 Ophthalmology
  
  Background We studied the association between (1) the retinal thickness, volume and structure assessed by optical coherence tomography (OCT), and (2) vascular changes around the fovea in FA to define the role of these methods in the detection of ischemic diabetic maculopathy. Methods This retrospective observational study included 51 eyes of 51 patients with severe non-proliferative and proliferative diabetic retinopathy, considering that they present advanced ischemic retinal changes. Based on the clinical examination and presence of leakage on FA, patients with clinically significant macular edema were excluded. On FA, foveal avascular zone (FAZ) corresponds to capillary loss and reflects ischemic ...
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6. Feature Of The Week 12/1/13: Simultaneous Dual Wavelength Eye-Tracked Ultrahigh Resolution Retinal and Choroidal OCT
  
  Explore Optical Coherence Tomography News Dec 1 2013 Ophthalmology
  
  An eye-tracked high resolution OCT device is presented for clinical multimodal imaging of the retina and the deep choroid, based on the platform of a commercial Heidelberg-Engineering SPECTRALIS® OCT device. The system is aimed to drive the development of novel therapeutic approaches for better eye care. The dual spectrometer based frequency domain OCT with built-in confocal scanning laser ophthalmoscope (SLO) operating at 735 nm, corrects for eye-motion in real time and enables arbitrary selection of the location of interest as well as automatic re-positioning of successive measurements or in follow up studies. Common clinical ophthalmic OCT devices perform raster scanning ...
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  Mentions: Wolfgang Drexler Heidelberg Engineering Exalos
7. Diagnostic Techniques: Optical Coherence Tomography (Book Chapter)
  
  Explore Home - Springer Nov 29 2013 Ophthalmology , Textbooks
  
  Optical coherence tomography (OCT) is a powerful imaging technique that provides cross-sectional imaging of the internal microstructures of biological tissues. Among several implementations of OCT, spectral-domain OCT (SD-OCT) provides high-resolution, high-sensitivity, and high-speed imaging. Such implementations enable visualization of the microstructures of the human eye by noninvasive and noncontact measurement. High sensitivity of OCT detection enables imaging of structures with very low optical scattering, such as the retina. The high axial and lateral resolution enables the precise morphological investigation of various pathological conditions. Recently, hardware and software upgrades have improved the ability to better evaluate intraocular tumors.
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8. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes
  
  Explore BJO Online Nov 29 2013 Ophthalmology
  
  Objective To compare spectral-domain optic coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) in the study of choroidal thickness (CT) in healthy eyes. Methods Prospective, cross-sectional, single-centre study. 82 healthy eyes of 46 patients were included. In a single session, Topcon 3D-2000 SD-OCT and 1050 nm SS-OCT prototype devices were used to perform OCT scans using a single line protocol. Two masked investigators independently, manually determined 13 CT measurements consisting of one subfoveal (SFCT), and six measurements on either side of the fovea (nasal and temporal) taken every 500 microns apart. The mean CT (MCT) was the mean average of these ...
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  Mentions: Topcon Medical Systems Topcon 3D OCT-2000
9. Optical Coherence Tomography and Visual Field Findings in Patients With Friedreich Ataxia
  
  Explore LWW Online Nov 29 2013 Neurology , Ophthalmology
  
  BACKGROUND:: To investigate the optical coherence tomography (OCT) and visual field findings in Friedreich ataxia (FRDA). METHODS:: Ten eyes of 10 patients with genetically confirmed FRDA were included in this study. Twenty-two eyes of 22 age- and sex-matched volunteers served as controls. All eyes were examined with spectral domain OCT (Retinascan Advanced RS-3000; NIDEK) and Humphrey Field Analyzer (HFA II 750; Zeiss-Humphrey Systems). RESULTS:: OCT measurements of the average peripapillary retinal nerve fiber layer (RNFL) thickness, average peripapillary retinal thickness (RT), and foveal RT showed a statistically significant reduction in patients with FRDA (P < 0.0001). There was no statistically ...
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  Mentions: Nidek Nidek RS-3000
10. Optical coherence tomography 2014
  
  Explore Healio.com Nov 29 2013 Ophthalmology
  
  Optical coherence tomography (OCT) is now widely recognized as the most important retinal imaging technique, replacing angiographic techniques as first-line imaging tools. This has largely been driven by widespread application of retinal pharmacotherapy. As a clinical decision-making tool in that setting, OCT has unparalleled value in delivering important information in a matter of seconds. OCT has dramatically improved the productivity of retinal specialists — ie, the number of patients who can be evaluated in a given clinical session. This special issue on OCT highlights its value as a quantitative tool in assessing retinal anatomy in both health and disease, its power ...
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  Mentions: Carmen A. Puliafito University of Southern California
11. Enhanced Depth Imaging OCT and Indocyanine Green Angiography Changes in Acute Macular Neuroretinopathy
  
  Explore Healio.com Nov 29 2013 Ophthalmology
  
  The authors describe indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a 46-year-old male patient with acute macular neuroretinopathy (AMN). The chief complaint was decreasing visual acuity and metamorphopsia in both eyes of 1-month duration. Visual field assessment, fluorescein angiography, OCT, ICGA, and EDI-OCT were performed initially and at 3 months. ICGA showed choroidal vascular hyperpermeability and punctuate choroidal hyperfluorescent spots, especially in the left eye. EDI-OCT showed increased choroidal macular thickness, with inner and outer retinal layers affected. EDI-OCT and ICGA reveal that both the choroid and retina can be affected in AMN; however ...
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  Mentions: University of Arizona Jerry A. Shields Lawrence A. Yannuzzi
12. Enhanced Visualization of the Choroido-Scleral Interface Using Swept-Source OCT
  
  Explore Healio.com Nov 29 2013 Ophthalmology
  
  An accurate analysis of the thickness and volume of choroid using optical coherence tomography (OCT) requires precise visualization of the choroido-scleral interface. Results of studies that use spectral-domain OCT (SD-OCT) to look at the percent visualization of the choroido-scleral interface for accurate analysis of choroidal thickness show varying success rates. This study assessed the visualization of choroido-scleral interface in 19 healthy participants (19 eyes) prospectively recruited for consecutive high-definition raster scanning with an SD-OCT system with and without enhanced depth imaging (EDI) and a prototype long-wavelength swept-source OCT (SS-OCT) system. Choroido-scleral interface was visualized in all eyes imaged on SS-OCT ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Optovue
13. Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography
  
  Explore PLoS ONE Nov 28 2013 Ophthalmology
  
  Purpose Thickness changes of corneal sub-layers after phacoemulsification were investigated by spectral domain ultra-high resolution optical coherence tomography (UHR-OCT). Methods The corneas (n = 26) of 26 age-related cataract surgery patients were studied. UHR-OCT was used to evaluate the thickness of Descemet’s Endothelium Complex (DEC), stroma, Bowman’s layer, epithelium, and full cornea at the center (CCT) before, one day after, and one week after surgery. Non-contact specular microscopy measured CCT, endothelial cell density, and morphology. Results The DEC, stroma, Bowman’s layer, and epithelium were visualized by UHR-OCT. Before surgery, the DEC in all cases appeared as a translucent ...
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  Mentions: Jianhua Wang Wenzhou Medical College University of Miami
14. Parametric Model for the 3D Reconstruction of Individual Fovea Shape from OCT Data
  
  Explore ScienceDirect Nov 28 2013 Ophthalmology
  
  As revealed by optical coherence tomography (OCT), the shape of the fovea may vary greatly among individuals. However, none of the hitherto available mathematical descriptions comprehensively reproduces all individual characteristics such as foveal depth, slope, naso-temporal asymmetry, and others. Here, a novel mathematical approach is presented to obtain a very accurate model of the complete 3D foveal surface of an individual, by utilizing recent developments in OCT. For this purpose, a new formula was developed serving as a simple but very flexible way to represent a given fovea. An extensive description of the used model parameters, as well as, of ...
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  Mentions: University of Leipzig
15. Combining Spectral Domain Optical Coherence Tomography Structural Parameters for the Diagnosis of Glaucoma with Early Visual Field Loss
  
  Explore iovs.org Nov 27 2013 Ophthalmology
  
  PURPOSE. To create a multivariable predictive model for glaucoma with early visual field loss using a combination of spectral domain optical coherence tomography (OCT) parameters, and to compare the results with single variable models. METHODS. Two hundred and fifty-three subjects (149 normal controls and 104 with early glaucoma) underwent optic disc and macular scanning using spectral domain OCT in one randomly selected eye per subject. Sixteen parameters (rim area, cup-to-disc area ratio, vertical cup-to-disc diameter ratio, average and quadrant RNFL thicknesses, average, minimum, and sectoral GCIPL thicknesses) were collected and submitted to an exploratory factor analysis (EFA) followed by logistic ...
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  Mentions: University of North Carolina Donald L. Budenz Jean C. Mwanza
16. Optical coherence tomography as a diagnostic tool for retinal pathologies in avian ophthalmology
  
  Explore iovs.org Nov 27 2013 Ophthalmology
  
  Purpose:Optical coherence tomography (OCT) is an established diagnostic tool for retinal pathologies in human eyes and was adapted to small animal models. However, there are only few attempts to use OCT for examinations of avian eyes and little is known about structural details of healthy or pathologically affected retinas in living birds. Methods:We used SD-OCT (High Resolution Spectral Domain OCT) to investigate eyes of various avian species including birds of prey. The birds were anesthetized by Isofluran application during OCT examination. Eyes of a common buzzard (Buteo buteo) could be used for a comparative analysis of OCT images ...
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  Mentions: University of Leipzig
17. En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy
  
  Explore Ophthalmology Nov 26 2013 Ophthalmology
  
  Objective To characterize en face features of the retinal pigment epithelium (RPE) and choroid in eyes with chronic central serous chorioretinopathy (CSCR) using a high-speed, enhanced-depth swept-source optical coherence tomography (SS-OCT) prototype. Design Consecutive patients with chronic CSCR were prospectively examined with SS-OCT. Participants Fifteen eyes of 13 patients. Methods Three-dimensional 6×6 mm macular cube raster scans were obtained with SS-OCT operating at 1050 nm wavelength and 100 000 A-lines/sec with 6 μm axial resolution. Segmentation of the RPE generated a reference surface; en face SS-OCT images of the RPE and choroid were extracted at varying depths every ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker
18. Analysis of Peripapillary Atrophy According to the Optic Disc Shape Using Spectral Domain OCT
  
  Explore KoreaMed Synapse Nov 26 2013 Ophthalmology
  
  Purpose To analyze the structural changes in the β-zone of peripapillary atrophy (PPA-β) using cross-sectional image of the optic disc head from spectral-domain optical coherence tomography (SD-OCT) according to the optic disc shape. Methods One hundred thirty-seven eyes in 137 patients with glaucoma having PPA-β and 31 normal eyes (control group) were evaluated retrospectively. Cross-sectional images of the optic disc were taken using the Cirrus HD-OCT. We classified optic disc patterns into normal, focal, myopic, generalized enlargement and senile sclerotic appearance types and analyzed the shape of Bruch's membrane (BM), composition of retinal layer and retinal slope according to ...
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  Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT
19. Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding
  
  Explore Healio.com Nov 26 2013 Ophthalmology
  
  BACKGROUND AND OBJECTIVE: To report a novel optical coherence tomography (OCT) finding in choroidal neovascularization (CNV). PATIENTS AND METHODS: The authors identified seven eyes with CNV demonstrating the atypical pattern of fluid accumulation within the outer retina on OCT. Patient demographics, best corrected visual acuity and spectral-domain OCT (SD-OCT) images were collected for all available follow-up visits. Volume and area of the fluid were measured on SD-OCT. Microperimetry was performed in one case. RESULTS: The outer retinal fluid was located between the external limiting membrane (ELM) and the outer photoreceptor band on SD-OCT. Within this area, the outer segments of ...
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  Mentions: Alexander C. Walsh University of Southern California Sandra Liakopoulos
20. The Posterior Choroidal Profiles Measured by Spectral Domain Optical Coherence Tomography in Healthy Korean Children
  
  Explore KoreaMed Synapse Nov 26 2013 Ophthalmology
  
  Purpose We assessed changes of the choroidal thickness in healthy Korean children using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and axial length. Methods Seventy-nine eyes (79 children) within ±1 diopter spherical equivalent underwent horizontal and vertical scan using EDI OCT. Two observers determined independently the choroidal thickness at 1 mm intervals from 3 mm nasal and 4 mm temporal to the fovea and 1 mm superior and inferior to the fovea using the manual caliper provided by the device software. Statistical analysis was performed to evaluate variations of choroidal thickness at ...
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21. Correlation Between Optical Coherence Tomography and Visual-Acuity in Chronic Central Serous Chorioretinopathy Treated with Half Dose Photodynamic Therapy
  
  Explore KoreaMed Synapse Nov 26 2013 Ophthalmology
  
  Purpose To evaluate the results of half-dose photodynamic therapy (PDT) and determine the correlation between morphological changes measured by spectral-domain optical coherence tomography (SD-OCT) and visual acuity in patients with chronic central serous chorioretinopathy (CSC). Methods Twenty-five eyes of 25 patients with chronic CSC who had received half-dose verteporfin PDT were enrolled in the present study. The best-corrected visual acuity (BCVA), outer nuclear layer (ONL) thickness, and the integrity of the photoreceptor inner and outer segment junction (IS/OS) using SD-OCT were evaluated at baseline and at 3 and 6 months after treatment. Results The neurosensory retinal detachment disappeared in ...
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  Mentions: Yonsei University
22. Optical Coherence Tomography in Pediatric Ophthalmology: Current Roles and Future Directions
  
  Explore Healio.com Nov 26 2013 Ophthalmology
  
  The application of existing optical coherence tomography (OCT) technology to the pediatric population is limited in both the design specification of the device and its hardware. However, the potential of OCT in the pediatric population has not been fully realized. The authors review the literature, highlighting the currently available spectral-domain OCT technology and summarizing the reported normal pediatric OCT parameters for retinal nerve fiber layer and macular thickness. They also review the pediatric ophthalmological conditions in which OCT has been used and discuss advancements in OCT design and their potential applications to the pediatric population. The use of OCT in ...
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  Mentions: University College London Harvard University Massachusetts Eye and Ear Infirmary
23. Response to anti-VEGF therapy in patients with subretinal fluid and pigment epithelial detachment on spectral-domain optical coherence tomography
  
  Explore Home - Springer Nov 26 2013 Ophthalmology
  
  Purpose To analyse the long-term functional and morphological response of a specific choroidal neovascular membrane (CNV) phenotype to anti-vascular endothelial growth factor (VEGF) therapy. Methods Data from 30 eyes of 30 consecutive patients with subretinal fluid (SRF) and fibrovascular pigment epithelial detachment (PED) due to CNV on spectral-domain optical coherence tomography (SDOCT) with a follow-up of at least 20 months were retrospectively collected. Main outcome measures included change in visual acuity, quantitative and qualitative parameters on SDOCT [photoreceptor layer, outer nuclear layer (ONL), choroid, PED, SRF] and on fluorescein angiography (CNV activity). Subjects were divided into responders and non-responders based ...
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  Mentions: University of Cologne Richard F. Spaide Lawrence A. Yannuzzi
24. Predictive value of optical coherence tomography on the outcome of lung adenocarcinoma with choroidal metastases
  
  Explore ScienceDirect Nov 26 2013 Ophthalmology , Pulmonology
  
  CLINICAL CASE: A 59 year-old male, with the diagnosis of lung adenocarcinoma stage iv, following palliative systemic chemotherapy treatment. He was referred to our department due to bilateral blurred vision. In the eye-fundus we observed: bilateral choroidal metastases with macular involvement, and in optical coherence tomography (OCT): neurosensory detachment in both eyes. This neurosensory detachment showed improvement with chemotherapy before the clinical and radiologic improvement. DISCUSSION: OCT could be a great tool in order to predict the response to systemic treatment in cases of lung adenocarcinoma associated with choroidal metastases.
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