Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Assessing age-related changes in the biomechanical properties of rabbit lens using a co-aligned ultrasound and optical coherence elastography system
  
  Explore iovs.org Jan 30 2015 Ophthalmology
  
  Purpose: To evaluate the capability of a novel co-aligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in situ. Methods: Low-amplitude elastic deformations in young and mature rabbit lenses were measured by the US-OCE system consisting of a spectral-domain optical coherence tomography (OCT) system co-aligned with focused ultrasound used to produce a transient force on the lens surface. Uniaxial compressional tests were used to confirm the OCE data. Results: The OCE measurements showed that the maximum displacements of the young rabbit lenses were significantly larger than those of ...
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  Mentions: Baylor College of Medicine Kirill V. Larin University of Houston
2. Sequential En Face Spectral-Domain Optical Coherence Tomographic Analysis of Macular Hole Formation
  
  Explore JAMA Network Jan 30 2015 Ophthalmology
  
  Idiopathic macular hole is a condition widely believed to result from disruption of retinal tissue due to anteroposterior vitreofoveal traction. 1 Previous reports have used spectral-domain optical coherence tomography (SD-OCT) to demonstrate cross-sectional images of macular hole formation in the setting of vitreomacular traction. 1 - 3 Herein, we present sequential en face SD-OCT analysis of an evolving macular hole to attempt to elucidate its pathogenesis.
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  Mentions: Brandon J. Lujan
3. Spectral Domain Optical Coherence Tomography Based Alterations in Macular Thickness and Inner Segment Ellipsoidare Associated with Severity of Diabetic Retinopathy
  
  Explore ClinMed International Library Jan 30 2015 Ophthalmology
  
  Objective: To study the association of spectral domain optical coherence tomography (SD-OCT) based alterations in macular thickness and inner segment-ellipsoid band (ISel) with severity of retinopathy in cases of type 2 diabetes mellitus. Method: Two hundred thirty eight consecutive cases and seventy nine healthy controls were included. Eyes of cases were divided into three groups according to ETDRS classification: diabetes without retinopathy (No DR) (n=79), non-proliferative diabetic retinopathy (NPDR) with macular edema (n=79), and proliferative diabetic retinopathy (PDR) with macular edema (n=80). Visual acuity was assessed using logMAR scale. Fasting and post prandial blood glucose and glycosylated ...
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  Mentions: Sandeep Saxena
4. Reproducibility of Optovue RTVue Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Zeiss Stratus Metrics in Diabetic Macular Edema
  
  Explore tvstjournal.org Jan 30 2015 Ophthalmology
  
  Purpose: To evaluate the reproducibility of central subfield thickness (CST) and volume measurements from optical coherence tomography (OCT) images obtained with Zeiss Stratus and Optovue RTVue, and formulate equations to convert these measurements from RTVue to ‘equivalent' Stratus values. Methods: Cross-sectional observational study from 309 eyes of 167 participants with diabetes and at least one eye with central-involved diabetic macular edema (DME; Stratus CST ≥ 250 μm) that underwent two replicate Stratus scans followed by two replicate RTVue scans centered on the fovea. Results: The Bland-Altman coefficient of repeatability for relative change in CST (the degree of change that could be ...
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  Mentions: Johns Hopkins University Optovue Duke University
5. Agreement between SD-OCT, Standard Automated Perimetry and Stereophotography in the detection of glaucomatous progression
  
  Explore iovs.org Jan 30 2015 Ophthalmology
  
  PURPOSE. To evaluate the agreement between spectral domain optical coherence tomography, standard automated perimetry and optic disc stereophotos in the detection of glaucomatous progression. METHODS. Observational cohort study enrolling 246 eyes (148 patients) followed-up for an average of 31.8 ± 9 months. Images were obtained every 6-12 months with optical coherence tomography, visual field and optic disc stereophotos. Progression was determined in OCT with the Glaucoma Progression Analysis software (GPA), in perimetry with the Humphrey Field Analyzer GPA and by masked assessment of stereophotographs series. Agreement among methods was reported using the Kappa coefficient (K), PABAK (prevalence-adjusted bias-adjusted kappa), Gwet ...
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6. Anterior segment optical coherence tomography evaluation of corneal epithelium healing time after 2 different surface ablation methods
  
  Explore smj.org.sa Jan 30 2015 Ophthalmology
  
  Objectives: To compare epithelial healing time following laser epithelial keratomileusis (LASEK) and photorefractive keratectomy (PRK) with anterior segment optic coherence tomography (AS-OCT). Methods: This prospective interventional case series study comprised 56 eyes of 28 patients that underwent laser refractive surgery in the Department of Ophthalmology, Medipol University Medical Faculty, Istanbul, Turkey, between March 2014 and May 2014. Each patient was randomized to have one eye operated on with PRK, and the other with LASEK. Patients were examined daily for 5 days, and epithelial healing time was assessed by using AS-OCT without removing therapeutic contact lens (TCL). Average discomfort scores were ...
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7. Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography
  
  Explore JAMA Network Jan 30 2015 Ophthalmology
  
  Importance Differences in ocular anatomy may contribute to ethnic differences in glaucoma risk. Because the trabecular meshwork (TM) plays an important role in aqueous outflow, its anatomy in relation to at-risk populations may provide insight into a potential contributor to elevated intraocular pressure and thus to probability of glaucoma development. Objective To investigate whether differences exist in TM height between ethnic groups. Design, Setting, and Participants This prospective study took place from January 1, 2012, to December 31, 2013. Adult patients who self-reported as being of white, Asian, Hispanic, or African American ethnicity were recruited from ophthalmology clinics at the ...
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  Mentions: Case Western Reserve University Shan C. Lin UCSF
8. Change in drusen area over time compared using spectral-domain optical coherence tomography and color fundus imaging
  
  Explore iovs.org Jan 29 2015 Ophthalmology
  
  Purpose. To investigate the relationship between drusen areas measured with color fundus images (CFIs) and those with spectral-domain optical coherence tomography (SDOCT). Methods. Forty-two eyes from thirty patients with drusen in the absence of geographic atrophy were recruited to a prospective study. Digital color fundus images and SDOCT images were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both CFIs and SDOCT images. Spectral-domain OCT drusen measurements were obtained using a commercially available proprietary algorithm. Drusen boundaries on ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Miami
9. The Application of Extended Field Imaging to Optical Coherence Tomography
  
  Explore Ophthalmology Jan 28 2015 Ophthalmology
  
  Since its invention, optical coherence tomography (OCT) has made remarkable advancements in both image resolution and acquisition speed. 1,2 With improvements in both hardware and software, higher resolution and less noisy retinal cross-sectional images can be obtained noninvasively. 3 Recent improvements to commercially available OCT systems have also included increasing scan length. For example, most spectral-domain OCT machines provide line scans that are approximately 9 mm in length. Therefore, a single scan can include the macula and part of the optic disc.
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  Mentions: Nagahisa Yoshimura Kyoto University Graduate School of Medicine
10. Heidelberg Engineering launches new software upgrade
  
  Explore Welcome Jan 28 2015 Ophthalmology , Other Business News
  
  Heidelberg Engineering has launched new software for its Spectralis 6.00 OCT (pictured). Key features of the new software include faster image acquisition and more intuitive analysis. The company believes that the free download reinforces the benefits of the technology being an upgradeable platform. The upgrade enables Spectralis users to gain more information from both new and previously taken scans, providing full segmentation of the retinal layers and longitudinal section analysis for a top down view. It comes with a comprehensive tutorial, highlighting the access to information on the integrity of specific layers. Heidelberg Engineering clinical programme manager, Christopher Mody ...
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  Mentions: Heidelberg Engineering Heidelberg Spectralis
11. Structural and functional changes in glaucoma: comparing the two-flash multifocal electroretinogram to optical coherence tomography and visual field
  
  Explore Home - Springer Jan 27 2015 Ophthalmology
  
  Purpose To correlate multifocal electroretinogram (mfERG) findings in the macular area of glaucoma patients with automated perimetry (visual fields) and with optical coherence tomography (OCT). Methods A two-global flash mfERG (VERIS™) was recorded in 20 eyes with primary open-angle glaucoma. The root mean square was calculated, and three response epochs were analysed: the direct component (15–45 ms) and two induced components (IC-1 at 45–75 ms and IC-2 at 75–105 ms). The central 10° of the mfERG was compared to the central 10° of the OCT and of the visual field. Responses grouped in a superior and in ...
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  Mentions: Medical University of Vienna Zeiss Cirrus HD-OCT Jeffrey M. Liebmann
12. Moment of Cyst Eruption Captured by Optical Coherence Tomography in Diabetic Macular Edema
  
  Explore LWW Online Jan 27 2015 Ophthalmology
  
  Photo Essay.
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13. Choroidal Imaging with Swept Source Optical Coherence Tomography – A Review
  
  Explore touchophthalmology.com Jan 27 2015 Ophthalmology
  
  The choroid provides up to 70 % of blood and oxygen to the eye. Pathological changes of this vascular tissue may lead to malnutrition of the retina and therefore be involved in the pathogenesis of numerous retinal disorders. Swept source optical coherence tomography (SS-OCT) is a new development of a non-invasive imaging technique that uses a tunable laser source with a higher wavelength light than conventional spectral domain OCT (SD-OCT). This enables visualisation of tissues below the retinal pigment epithelium. Thanks to SS-OCT’s ultrahigh speed and ultrahigh resolution it is possible to assess choroidal layers as well as to automatically ...
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  Mentions: Zofia Michalewska
14. Haag-Streit UK appointed sole distributor of the Optovue, Inc. portfolio in the UK
  
  Explore Optical Coherence Tomography News Jan 26 2015 Ophthalmology , Other Business News
  
  Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce that it will be appointed sole distributor of the Optovue, Inc. product portfolio in the UK from 4th February 2015. Optovue, Inc, has a reputation for pushing the frontiers of innovation and ophthalmic medical diagnostic imaging with its Optical Coherence Tomography (OCT) product portfolio, which includes the: Angiovue OCT Angiography system, iVue, iFusion, iScan and XR Avanti OCT products. HS-UK will be taking over the UK distribution from Watford-based Grafton Optical, Optovue, Inc distributors since January 2007. Bill Shields, Vice President International ...
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  Mentions: Optovue Haag-Streit Optovue iVue
15. Utility Of Optical Coherence Tomography In The Evaluation Of Patients With Ethambutol-Induced Optic Neuropathy
  
  Explore ISPUB Jan 25 2015 Ophthalmology
  
  In this study, optical coherence tomography (OCT) was used to evaluate retinal thickness in two patients with optic neuropathy who had recently discontinued ethambutol. OCT was used to measure retinal nerve fiber layer (RNFL) thickness and to map the RNFL, ganglion cell layer (GCL), and inner plexiform layer (IPL). Decreased RNFL thickness was observed in one case. However, the combined RNFL, GCL, and IPL map showed significant decreases in retinal thickness in both cases, suggesting that ethambutol likely affects the GCL as well as the RNFL. I propose that the GCL thickness should be considered in addition to the RNFL ...
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  Mentions: Nidek Nidek RS-3000
16. OCT measurements of optic nerve head changes in idiopathic intracranial hypertension
  
  Explore Clinical Neurology and Neurosurgery Jan 24 2015 Neurology , Ophthalmology
  
  Objective Severity of papilledema and vision loss constitute a basis for therapeutic intervention in idiopathic intracranial hypertension (IIH), but both are often subjective and insensitive in guiding clinical management. The aim of this study was to identify reliable and sensitive measurements of optic nerve head (ONH) and macula, to provide objective guidance for prognostic evaluation and treatment in IIH. We analyzed potential of spectral domain optical coherence tomography (SD-OCT), to measure neuro-retinal rim thickness and area, optic cup-to-disc ratio (C/D) and cup volume of ONH which have not previously been reported in IIH. In parallel, thickness of peripapillary retinal ...
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  Mentions: Timm Oberwahrenbrock
17. Longitudinal modifications of the Ozurdex intravitreal implant as imaged by SD-OCT
  
  Explore eur-j-ophthalmol.com Jan 24 2015 Ophthalmology
  
  To describe in vivo longitudinal modifications of the Ozurdex intravitreal implant using spectral-domain optical coherence tomography (SD-OCT) over a 6-month period in an eye treated for retinal vein occlusion (RVO). Case report. An 82-year-old woman with severe macular edema secondary to branch RVO received an Ozurdex intravitreal implant in the left eye. At day 1, SD-OCT showed that the implant was completely filled with highly reflective dexamethasone. At day 30, complete resolution of macular edema on SD-OCT was noted. At day 60, macular edema started to relapse; SD-OCT scans over the implant showed highly reflective borders that appeared irregular and ...
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  Mentions: University of Milan Giulio Barteselli
18. Fluorescein angiography and optical coherence tomography in myopic choroidal neovascularization
  
  Explore Nature Publishing Group Jan 24 2015 Ophthalmology
  
  Purpose To assess intra / inter-observer agreement, and diagnostic capabilities of a color fundus photograph, fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) in making a diagnosis of myopic choroidal neovascularization (CNV). Patients and methods Two masked observers evaluated FFA and SD-OCT images to identify the presence of myopic CNV in 80 high-myopic eyes of 57 patients. A third masked observer identified CNV on a color fundus photo. Presence of myopic CNV on a fundus photo was defined as presence of subretinal hemorrhage, thickening of the retina and / or visible membrane at the macula. Presence of myopic CNV ...
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  Mentions: L V Prasad Eye Institute King Khaled Eye Specialist Hospital Igor Kozak
19. Fast segmentation of anterior segment optical coherence tomography images using graph cut
  
  Explore Eye and Vision Jan 22 2015 Ophthalmology
  
  BackgroundOptical coherence tomography (OCT) is a non-invasive imaging system that can be used to obtain images of the anterior segment. Automatic segmentation of these images will enable them to be used to construct patient specific biomechanical models of the human eye. These models could be used to help with treatment planning and diagnosis of patients.MethodsA novel graph cut technique using regional and shape terms was developed. It was evaluated by segmenting 39 OCT images of the anterior segment. The results of this were compared with manual segmentation and a previously reported level set segmentation technique. Three different comparison techniques ...
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  Mentions: Yalin Zheng
20. Evaluation of a Method for Estimating Retinal Ganglion Cell Counts Using Visual Fields and Optical Coherence Tomography
  
  Explore iovs.org Jan 22 2015 Ophthalmology
  
  Purpose : To evaluate the accuracy and generalizability of a published model that derives estimates of retinal ganglion cell (RGC) counts and relates structural and functional changes due to glaucoma. Methods : Both the Harwerth et al. non−linear model (H−NLM) and the Hood and Kardon linear model (HK−LM) were applied to an independent dataset of frequency−domain optical coherence tomography and visual fields, consisting of 48 eyes of 48 healthy controls, 100 eyes of 77 glaucoma patients and suspects, and 18 eyes of 14 non−arteritic anterior ischemic optic neuropathy (ION) patients with severe vision loss. Using the coefficient ...
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  Mentions: Columbia University Donald C. Hood Ali S. Raza
21. Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)
  
  Explore Ophthalmology Jan 21 2015 Ophthalmology
  
  Mwanza et al 1 evaluated the performance of ganglion cell inner-plexiform layer (GCIPL) parameters used alone or in combination with retinal nerve fiber layer (RNFL) and optic nerve head parameters for the early diagnosis of glaucoma. They also provide positive (PLR) and negative (NLR) likelihood ratios (LR) that are valuable for clinical use.
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  Mentions: University of Queensland
22. Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration
  
  Explore Ophthalmology Jan 21 2015 Ophthalmology
  
  In the article by Castillo et al 1 (see page 399 ), the authors provide a thoughtful review of “the accuracy of optical coherence tomography (OCT) [compared] with alternative tests for monitoring neovascular age-related macular degeneration (nAMD) and detecting disease activity among eyes previously treated for this condition.” The topic is important. The article focuses mainly on whether OCT can replace fluorescein angiography (FA) because OCT is safer, more convenient, and less costly. Their conclusion is that OCT cannot replace FA: “There is a substantial disagreement between OCT and FA findings in detecting active disease in patients with nAMD who are ...
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23. Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography
  
  Explore Wiley Online Library Jan 21 2015 Ophthalmology
  
  Purpose The aim of this study was to assess the effect of a single drop of hyaluronic acid on tear film thickness (TFT) in healthy subjects. Methods Sixteen healthy subjects (eight male/eight female) aged between 20 and 36 years were included in this randomized, double-masked placebo-controlled study. One eye received a single dose of hyaluronic acid (Olixia pure ® ; Croma Pharma, Korneuburg, Austria) eye drops, and the fellow eye received physiologic saline solution as placebo control. The study eye was chosen randomly. TFT as measured with a custom-built Fourier-domain optical coherence tomography (FD-OCT) system was the main outcome variable and ...
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  Mentions: Medical University of Vienna Angelika Unterhuber
24. OPTICAL COHERENCE TOMOGRAPHY-BASED POSITIONING REGIMEN FOR MACULAR HOLE SURGERY
  
  Explore LWW Online Jan 21 2015 Ophthalmology
  
  Purpose: To evaluate an optical coherence tomography (OCT)-based positioning regimen for patients undergoing macular hole surgery. Method: We reviewed the medical records of all patients in our practice who underwent macular hole repair, instituting a modified OCT-based positioning regimen from November 1, 2011 through July 31, 2013. The regimen consisted of prone positioning at the conclusion of surgery with daily OCT imaging until the hole was confirmed closed at which point positioning was halted. Clinical data that were collected and recorded included visual acuities, stage of hole, size of hole, chronicity, preoperative and postoperative OCT imaging, and length of ...
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  Mentions: University of Toronto
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