1. Articles in category: Ophthalmology

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    1. Influence of sleep quality on macula and retinal nerve fiber layer in caucasian healthy adolescents: A cross-sectional assessment with optical coherence tomography

      Influence of sleep quality on macula and retinal nerve fiber layer in caucasian healthy adolescents: A cross-sectional assessment with optical coherence tomography

      Abstract Objective: Poor sleep quality have affect on neuronal structure in central nervous system. We aimed to investigate the effects of sleep quality on the thickness of retinal nerve fiber layer (RNFL), macula, and ganglion cell complex (GCC) obtained by optical coherence tomography (OCT) in healthy Caucasian adolescents. Methods: In this prospective cross-sectional study,100 healthy adolescents were evaluated for determining of sleep quality score by the Pittsburgh sleep quality index(PSQI) and were monitored for detection of sleep efficiency(%) by Sense Wear PRO3 Armband mobile monitor(SWA). The sleep quality is evaluated based on the PSQI score and PSQI ...

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    2. Comparison of measurements of anterior chamber angle via anterior segment optical coherence tomography and ultrasound biomicroscopy

      Comparison of measurements of anterior chamber angle via anterior segment optical coherence tomography and ultrasound biomicroscopy

      BACKGROUND Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision. The variable clinical manifestations may result in differential diagnostic difficulties. The early screening and diagnosis of glaucoma are currently experiencing a demand for anterior segment analysis tools that can gather more information with one short measurement. Therefore, we analyzed the agreement, difference, and correlation of chamber angle parameters such as angel opening distance at 500 μm (AOD500) and trabeculo-iris space area at 500 μm 2 (TISA500) measured by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). AIM To compare the differences ...

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    3. Optical coherence tomography angiography (OCTA) findings of microvascular and neural changes in primary pulmonary hypertension

      Optical coherence tomography angiography (OCTA) findings of microvascular and neural changes in primary pulmonary hypertension

      Aim: To investigate the microvascular and neural changes in primary pulmonary hypertension (PPH) patients compared with healthy controls. Method: Forty-four eyes of 22 PPH patients were included in this observational clinical cohort study, while forty-four eyes of 22 healthy participants were enrolled as controls. Optical coherence tomography angiography (OCTA) images were obtained from each participant using the RTVue XR Avanti device with AngioVue software 2.0. Results: Regarding the total macular-associated vessel density (VD), including that of the superficial and deep retina , the optic disc-associated capillary density (CD), including that of the whole image, CD inside the disc and the ...

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    4. Optical coherence tomography vs fundus photography in detecting macular edema in subjects with type 2 diabetes (Thesis)

      Optical coherence tomography vs fundus photography in detecting macular edema in subjects with type 2 diabetes (Thesis)

      Introduction The screening of diabetic retinopathy has been relied on fundus photography but since it is 2-dimensional, it is difficult to identify diabetic macular edema (DME), which is the most feared ocular complication related to diabetes. Optical coherence tomography (OCT) has been shown to be a useful tool in detecting and monitoring DME. The main objective of this study was to screen people with type 2 diabetes and find out how many patients have current diabetic macular edema and to compare different screening equipment by means of fundus photography and OCT when evaluating macular edema. Method The sample of this ...

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    5. Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography

      Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography

      Müller cells (MC) represent a key element for the metabolic and functional regulation of the vertebrate retina. The aim of the present study was to test the feasibility of a new method for the in-vivo detection and quantification of extrafoveal MC in human retina. We developed a new approach to isolate and analyse extrafoveal MC in vivo, starting from structural optical coherence tomography data. Our pilot investigation was based on the optical properties of MC, which are known to not interfere with the light reaching the outer retinal structures. We reconstructed MC in the macular region of 18 healthy ...

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    6. Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Abstract Purpose : To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods : In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT. We autosegmented OCT volumes using custom infant-specific software, extracted RVSV-OCT images from volumetric data bracketed around the retinal pigment epithelium, and automontaged the resulting RVSV-OCT images. Three masked ophthalmologists graded ...

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    7. Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

      Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

      Purpose : To analyze the appearance of structural abnormalities due to hydroxychloroquine (HCQ) toxicity by spectral-domain optical coherence tomography (SD-OCT) and short-wavelength autofluorescence (SW-AF) and near-infrared fundus autofluorescence (NIR-AF) imaging. Methods : This retrospective cohort study included 88 eyes from 44 patients who had a history of or were currently taking HCQ. SD-OCT, SW-AF, and NIR-AF images were analyzed by two independent graders for the detection of HCQ-associated abnormalities. Results : Sixty eyes (30 patients, 68%) presented with no abnormalities for either imaging modality. Twenty eyes (10 patients, 23%) presented with parafoveal abnormalities (ellipsoid zone attenuation and/or interdigitation zone continuity loss) in ...

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    8. Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption

      Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption

      Northwestern University Receives a 2020 NIH Grant for $516,102 for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption. The principal investigator is Hao Zhang. Below is a summary of the proposed work. Our long-term goal is to develop new functional extensions of optical coherence tomography (vis-OCT) for clinical diagnosis and management of glaucoma. Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) and optic nerve defects and atrophy, afflicting more than 60 million people worldwide. It is often develops slowly with symptoms and damage that are not noticed at early stage. Caring for those ...

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    9. Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT Evolution to Reveal Early-Stage Changes in Glaucoma

      Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT Evolution to Reveal Early-Stage Changes in Glaucoma

      Legacy Emanuel Hospital and Health Center Receives a 2020 NIH Grant for $543,351 for Advancing OCT Evolution to Reveal Early-Stage Chalnges in Glaucoma. The principal investigator is Brad Fortune. Below is a summary of the proposed work. Currently, diagnosis of glaucoma and patient management decisions are often informed by thinning of the optic nerve head (ONH) neuro-retinal rim, peripapillary retinal nerve fiber layer (RNFL), and macular inner retinal layers, as detected using optical coherence tomography (OCT). These measurements are useful because they are predictive of subsequent visual field decline, and of faster rates of subsequent thinning. However, by the ...

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    10. A pilot exploration using optical coherence tomography angiography analysis of capillary vascular density and foveal avascular zone for the diagnosis of uveal melanoma

      A pilot exploration using optical coherence tomography angiography analysis of capillary vascular density and foveal avascular zone for the diagnosis of uveal melanoma

      Dear Editor, Choroidal melanoma is a rare malignancy, and in one study from the United Kingdom, up to 30% of patients referred by the general ophthalmologist to an ocular oncology center were misdiagnosed. [1] Later, the mnemonic “To find small ocular melanoma using helpful hints daily” [2] was established to aid in the detection of this malignancy at an early point. With the rapid advancements in ocular imaging technology, quantifiable and objective tests are becoming more ubiquitous in ophthalmology. In glaucoma, standardized, automated, quantifiable, and objective optical coherence tomography (OCT) peripapillary and macular diagnostic parameters have been shown to have ...

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    11. OCT-Angiography in Geographic Atrophy

      OCT-Angiography in Geographic Atrophy

      Geographic atrophy (GA) represents the nonexudative late stage of age-related macular degeneration (AMD) and constitutes a leading cause of legal blindness in the developed world. It is characterized by areas of loss of outer retinal layers including photoreceptors, degeneration of the retinal pigment epithelium, and rarefication of the choriocapillaris. As all three layers are functionally connected, the precise temporal sequence and relative contribution of these layers towards the development and progression of GA is unclear. The advent of optical coherence tomography angiography (OCT-A) has allowed for three-dimensional visualization of retinal blood flow. Using OCT-A, recent studies have demonstrated that choriocapillaris ...

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    12. Preoperative Optical Coherence Tomography Findings of Foveal Splitting Rhegmatogenous Retinal Detachment

      Preoperative Optical Coherence Tomography Findings of Foveal Splitting Rhegmatogenous Retinal Detachment

      To assess preoperative optical coherence tomography (OCT) findings of foveal splitting retinal detachment (RD), and to determine their postoperative outcomes. Consecutive patients who underwent RD surgery over a one-year period were included. Patients diagnosed with a detachment extending to the edge of the fovea on fundus examination (i.e. macula-On/Off) underwent macular OCT scanning. One-year visual acuity (VA) of macula-On/Off, macula-On and macula-Off eyes was compared. 85 eyes were included, of which 8 had a macula-On/Off RD. On preoperative OCT, all macula-On/Off RD had a foveal detachment extending beyond the foveal center, over a median distance ...

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    13. Multifocal electroretinography and spectral-domain OCT in macula-off rhegmatogenous retinal detachment. A prospective cohort study

      Multifocal electroretinography and spectral-domain OCT in macula-off rhegmatogenous retinal detachment. A prospective cohort study

      Purpose: To analyze the temporal trends in structural changes using spectral domain – optical coherence tomography (SD-OCT) and functional changes using multifocal electroretinogram (mfERG) after rhegmatogenous retinal detachment (RRD) surgery. Methods: This prospective cohort study enrolled 69 patients with macula-off RRD who underwent successful surgery. ETDRS visual acuity, mfERG evaluation of the central 5 degrees, and SD-OCT were recorded at 1, 3, 6, and 12 months (M) after surgery. The fellow eye served as the control group for mfERG parameters. Results: Between M1 and M12, visual acuity improved from 64 to 75 letters ( P =0.001) and implicit time of N1 ...

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    14. In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

      In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

      Spectral-domain optical coherence tomography (SD-OCT) is useful for visualizing retinal and ocular structures in vivo . In research, SD-OCT is a valuable tool to evaluate and characterize changes in a variety of retinal and ocular disease and injury models. In light induced retinal degeneration models, SD-OCT can be used to track thinning of the photoreceptor layer over time. In glaucoma models, SD-OCT can be used to monitor decreased retinal nerve fiber layer and total retinal thickness and to observe optic nerve cupping after inducing ocular hypertension. In diabetic rodents, SD-OCT has helped researchers observe decreased total retinal thickness as well as ...

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      Mentions: Emory University
    15. Objective Imaging Diagnostics for Dry Eye Disease

      Objective Imaging Diagnostics for Dry Eye Disease

      Traditional diagnostic tests for dry eye disease (DED), such as fluorescein tear film break-up time and the Schirmer test, are often associated with poor reproducibility and reliability, which make the diagnosis, follow-up, and management of the disease challenging. Advances in ocular imaging technology enables objective and reproducible measurement of changes in the ocular surface, tear film, and optical quality associated with DED. In this review, the authors will discuss the application of various imaging techniques, such as, noninvasive tear break-up time, anterior segment optical coherence tomography, in vivo confocal microscopy, meibography, interferometry, aberrometry, thermometry, and tear film imager in DED ...

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    16. Colocalization of optical coherence tomography angiography with histology in the mouse retina

      Colocalization of optical coherence tomography angiography with histology in the mouse retina

      Optical coherence tomography angiography (OCT-A) allows in vivo , non-invasive, functional imaging of retinal perfusion. The purpose of this study was to determine the reliability of OCT-A in visualizing the complete retinal vasculature by comparing in vivo OCT-A images to matched ex vivo tissue in mice. Adult female C57BL/6 mice were imaged to obtain OCT-A images of the superficial vascular complex, intermediate capillary plexus and deep capillary plexus. Z-stack fluorescence images of whole-mounted retinas, labeled for vascular endothelial cells by anti-isolectin immunohistochemistry and FITC-dextran perfusion, were generated. The OCT-A and fluorescence images were manually colocalized and vessel length measured for ...

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    17. Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography

      Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography

      Background: Vitiligo is a common skin condition affecting 0.5– 2% of the population. The exact etiology of the condition is unknown, but the result is autoimmune destruction of melanocytes. The eye is rich in melanocytes, especially in the retinal pigment epithelium and choroid. Little is known about the effect of vitiligo on the choroid of the eye. Methods: We cross-sectionally examined 31 right eyes of 31 vitiligo patients and 32 right eyes of 32 age- and sex-matched controls for signs of vitiligo affection and then measured the subfoveal choroidal thickness (SFCT) using spectral-domain optical coherence tomography. Results: There was ...

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    18. Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

      Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

      The objective of this study is to perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment. Subjects will be identified from healthy subjects (seen for screening eye exams) and diseased subjects undergoing standard-of-care treatment or screening at eye clinic locations. The study population will include subjects with retinal vascular disease including but not limited to diabetic retinopathy, hypertension, retinal vein/arterial ...

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      Mentions: FDA
    19. The effect of software versions on the measurement of retinal vascular densities using optical coherence tomography angiography

      The effect of software versions on the measurement of retinal vascular densities using optical coherence tomography angiography

      Background The goal of the study was to determine the effect of different software versions on the measurement of retinal vessel densities using optical coherence tomography angiography (OCTA) in normal subjects. Methods Thirty-two eyes of eighteen healthy subjects were imaged using two OCTA devices: the Optovue RTVue and the Zeiss Cirrus. The macular 3 × 3 mm scan protocol was used. The images acquired using the Optovue OCTA device were exported using two different software versions in the system and compared to the images acquired through the Zeiss OCTA. In addition, the Optovue OCTA images were exported after manual adjustment of ...

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    20. Peripapillary and Macular Microcirculation in Glaucoma Patients of African and European Descent Using Optical Coherence Tomography Angiography

      Peripapillary and Macular Microcirculation in Glaucoma Patients of African and European Descent Using Optical Coherence Tomography Angiography

      Précis: We found no significant differences in peripapillary and macula microcirculation blood flow metrics in eyes with open angle glaucoma of African descent (AD) and European Descent (ED) as detected by optical coherence tomography-angiography ( OCTA ). Purpose: To investigate the peripapillary retinal nerve fiber layer (RNFL) and macular vascular microcirculation in subjects of African descent (AD) and European descent (ED) with open-angle glaucoma using optical coherence tomography-angiography ( OCTA ). Patients and Methods: One eye from each subject was scanned using AngioPlex OCTA system (Zeiss Meditec Inc., Dublin, CA) covering both a 6 ×6▒mm scanning area centered at the optic nerve ...

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    21. Comparison of two swept-source optical coherence tomography-based biometry devices

      Comparison of two swept-source optical coherence tomography-based biometry devices

      Purpose: To compare two swept-source optical coherence tomography (SS-OCT) biometers, IOLMaster 700 (biometer A, Carl Zeiss Meditec AG), and ANTERION (biometer B, Heidelberg Engineering GmbH). Setting: Vienna Institute for Research in Ocular Surgery – Karl Landsteiner Institute, Hanusch Hospital, Department of Ophthalmology, Vienna, Austria. Design: Retrospective study. Method: Cataract patient biometric measurements performed between June and July 2019 were reviewed. Patients scheduled for cataract surgery were measured with both SS-OCT devices on the same day. The following biometry parameters were compared: keratometry, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and axial length (AL). Result: In total, 389 ...

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    22. Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes

      Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes

      We investigated the microvascular changes in eyes with lamellar macular holes (LMHs) using optical coherence tomography angiography (OCTA), compare them between two subtypes of LMH. Tractional and degenerative LMH were differentiated based on the morphological characteristics of OCT. In OCTA images, foveal and parafoveal vessel density (VD) in the superficial and deep capillary plexus (SCP, DCP) and foveal avascular zone (FAZ) area were measured. Eyes that underwent vitrectomy for LMH were included in subgroup analysis. We analysed 63 LMH (42 tractional and 21 degenerative) eyes and 63 control eyes. Compared with degenerative LMH, tractional LMH had better BCVA ( p  = 0 ...

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    23. Early Diagnostic Value of Spectral Domain-optical Coherence Tomography for Optic Nerve Injury in Sellar-occupied Patients

      Early Diagnostic Value of Spectral Domain-optical Coherence Tomography for Optic Nerve Injury in Sellar-occupied Patients

      Background: To investigate the value of spectral domain-optical coherence tomography (SD-OCT) in the early diagnosis of optic nerve injury in patients with occupying lesion in sellar region. Methods: A case-control study was conducted for patients who were diagnosed as the occupying lesion in sellar region in the Department of Ophthalmology. The general routine examination and visual field examination were performed in the ophthalmology department. A total of 22 patients(44 eyes) with no abnormalities were selected, and 22 healthy controls (44 eyes) were enrolled. SD-OCT was used to detect the average thickness of peripapillary retinal nerve fiber layer (pRNFL) and ...

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    24. Differences between Scheimpflug and optical coherence tomography in determining safety distances in eyes with an iris-fixating phakic intraocular lens

      Differences between Scheimpflug and optical coherence tomography in determining safety distances in eyes with an iris-fixating phakic intraocular lens

      Purpose To investigate the agreement and reliability of anterior segment optical coherence tomography (AS-OCT) and Scheimpflug imaging in measuring the distance from the anterior edge of an iris-fixated phakic intraocular lens (IF-pIOL) to the corneal endothelium. Methods Anterior segment configuration was assessed in a total of 62 eyes of which 25 hyperopic and 37 myopic eyes, all corrected with an IF-pIOL. Measurements were performed by two independent observers using AS-OCT (Visante, Model 1000, Carl Zeiss Meditec Inc.) and Scheimpflug imaging (Pentacam HR, Oculus Optikgerate). The distance from the anterior edge of the pIOL to the endothelium was measured in five ...

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