Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Two Postdoctoral Positions in Optical imaging at Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA
  
  Explore Optical Coherence Tomography News Apr 19 2014 Ophthalmology , Jobs & Studentships
  
  The Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University, is seeking outstanding candidates for the following positions in optical imaging research in the field of ophthalmology. v Post-Doc (hardware): develop optical imaging instruments Requirements: Skills in optics (optical design, microscope or fiber optics). Experience of programming with C++ or LabView for data acquisition and equipment control. Experience of optical coherence tomography (OCT) is desirable but not a must. PhD degree in a relevant discipline (Optics, Electrical Engineering, Biomedical Engineering, Physics). The successful candidate will be supervised by David Huang, MD, PhD and ...
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
2. Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture
  
  Explore PLoS ONE Apr 18 2014 Ophthalmology
  
  Purpose To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT). Methods Thirty-nine eyes (8 healthy, 19 glaucoma suspects and 12 glaucoma) from 49 subjects were scanned twice using swept-source (SS−) OCT in a 3.5×3.5×3.64 mm (400×400×896 pixels) volume centered on the optic nerve head, with the focus readjusted after each scan. The LC was automatically segmented and analyzed for microarchitectural parameters, including pore diameter, pore diameter standard deviation (SD), pore aspect ratio, pore area, beam thickness, beam thickness SD, and ...
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  Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto
3. Swept-source OCT and glaucoma
  
  Explore eyeworld.org Apr 18 2014 Ophthalmology , Tunable Sources
  
  A technology being investigated for use in posterior segment imaging may have a role in glaucoma diagnosis, according to the literature First there was time-domain optical coherence tomography (TD-OCT), then spectral-domain OCT (SD-OCT); now a newer technology—swept-source OCT—may be able to image structures that the previous technologies could not, according to researchers involved in clinical studies of the device. "With swept-source technology, a frequency swept light source and a high speed detector are used to detect the interference signal as a function of time, instead of a spectrometer and camera as in spectral-domain technology," explained James G. Fujimoto ...
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  Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto
4. Orthogonal dispersive spectral-domain optical coherence tomography
  
  Explore opticsinfobase.org Apr 18 2014 Ophthalmology
  
  Ultrahigh depth range spectral domain optical coherence tomography (SDOCT) can be realized based on the orthogonal dispersive spectrometer consisted by a high spectral resolution virtually-imaged phased array (VIPA) and a low spectral resolution grating. However, two critical issues result in the challenge of obtaining desirable one-dimensional (1-D) spectra from the recorded two-dimensional (2-D) orthogonal spectra for high-quality OD-SDOCT imaging. One is the wavenumber mapping errors and the other is the periodic intensity modulations. The paper proposes a method for desirable reconstruction of 1-D spectra from the recorded 2-D orthogonal spectra. A sample etalon with identical parameters to the dispersive VIPA ...
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  Mentions: Zhihua Ding Zhejiang University
5. Intra-operative OCT devices for ophthalmic use: an overview
  
  Explore Home - Springer Apr 17 2014 Ophthalmology
  
  It is feasible to bring the currently most used examination method in ophthalmology, optical coherence tomography (OCT), into ophthalmic surgery to enhance information and control for the surgeon and increase outcome for the patient. In this overview, the currently commercially available OCT devices intending intra-operative OCT imaging are described. Further experience with these systems might not only aid in solving current problems but also open our minds to detect processes so far unknown and help answer questions so far unaddressed.
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  Mentions: Optovue Heidelberg Engineering Cornell University
6. Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT
  
  Explore iovs.org Apr 17 2014 Ophthalmology
  
  Purpose: Subthreshold laser treatment of diabetic macular edema (DME) may have less deleterious effects on the photoreceptors than regular continuous wave laser. This study aimed to assess whether subthreshold laser causes a long-term damage to the retinal structures, as demonstrated by spectral-domain optical coherence tomography (SD-OCT), and to evaluate the change in the axial diameter of retinal diabetic microaneurysms following treatment. Methods: A retrospective study of eyes that were diagnosed with non-foveal involving DME and underwent subthreshold laser treatment with the Lumenis Novus SRT system. SD-OCT scans of treated retinal areas, performed prior to treatment and approximately 4 months following ...
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7. Hyperreflective Pyramidal Structures on Optical Coherence Tomography in Geographic Atrophy Areas
  
  Explore LWW Online Apr 17 2014 Ophthalmology
  
  Purpose: We observed hyperreflective dome-shaped or pyramidal structures (HPS) on spectral domain optical coherence tomography (SD-OCT) in patients affected with geographic atrophy (GA). Our purpose was to describe the multimodal imaging features of HPS identified in areas of GA in patients with age-related macular degeneration. Methods: This is a retrospective case series of patients with GA harboring HPS in atrophic areas. Multimodal imaging examination including infrared reflectance, fundus autofluorescence, and SD-OCT, was performed for each patient. Infrared and fundus autofluorescence appearance and mean SD-OCT height of HPS in GA were analyzed. Results: A total of 36 eyes of 25 patients ...
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  Mentions: Centre Hospitalier Intercommunal de Créteil Giuseppe Querques Eric H. Souied
8. Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography
  
  Explore iovs.org Apr 17 2014 Neurology , Ophthalmology
  
  Purpose: To calculate and validate a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD). Method: AD patients (n=151) and age-matched, healthy subjects (n=61) were enrolled. The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. A LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided ...
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  Mentions: Miguel Servet University Hospital Zeiss Cirrus HD-OCT José M. Larrosa
9. Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery
  
  Explore PLoS ONE Apr 17 2014 Ophthalmology
  
  Purpose To report the observation of hyper-reflective dots in the vitreous cavity using spectral domain optical coherence tomography (SD-OCT) after uneventful phacoemulsification cataract surgery and to investigate their association with cystoid macular edema (CME). Materials and Methods Medical records of consecutive Asian patients who had no preoperative retinopathy and underwent uneventful phacoemulsification cataract surgery from March 2012 through February 2013 were reviewed. SD-OCTs were performed before, 1 week, and 1 month after surgery. The number of vitreous hyper-reflective dots (VHDs) was counted in 5 OCT images of high-definition 5-line raster scans. The development of CME was assessed using postoperative 1-month ...
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  Mentions: Harvard University Carl Zeiss Meditec Zeiss Cirrus HD-OCT
10. Measurement of wavefront aberrations and lens deformation in the accommodated eye with optical coherence tomography-equipped wavefront system
  
  Explore opticsinfobase.org Apr 16 2014 Ophthalmology
  
  To quantitatively approach the relationship between optical changes in an accommodated eye and the geometrical deformation of its crystalline lens, a long scan-depth anterior segment OCT equipped wavefront sensor was developed and integrated with a Badal system. With this system, accommodation was stimulated up to 6.0D in the left eye and also measured in the same eye for three subjects. High correlations between the accommodative responses of refractive power and the radius of the anterior lens surface were found for the three subjects (r>0.98). The change in spherical aberration was also highly correlated with the change in ...
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  Mentions: Jianhua Wang University of Miami
11. Advancing OCT Algorithmic Standardization
  
  Explore iovs.org Apr 15 2014 Ophthalmology
  
  Neovascular exudative AMD (wet AMD) continues to rank as a top reason to visit eye care specialists, and the early identification of this disease has important prognostic implications for patients. 1 Advancements in optical coherence tomography (OCT) imaging have surpassed other modalities in the ability to detect the earliest development of wet AMD and prompt treatment initiation, in spite of lack of inter- and intradevice standardization. 2 , 3 Zhang et al. 4 present a novel, automated way to detect changes at the border where choroidal neovascularization (CNV) first affects the retina. They use a technique that presents an automated method ...
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12. Virtual reality simulator for vitreoretinal surgery using integrated OCT data
  
  Explore Medical Journals Publisher Apr 15 2014 Ophthalmology
  
  Operative practice using surgical simulators has become a part of training in many surgical specialties, including ophthalmology. We introduce a virtual reality retina surgery simulator capable of integrating optical coherence tomography (OCT) scans from real patients for practicing vitreoretinal surgery using different pathologic scenarios.
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  Mentions: Igor Kozak
13. Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome
  
  Explore eur-j-ophthalmol.com Apr 15 2014 Ophthalmology
  
  PurposeTo describe the characteristic optical coherence tomography (OCT) findings of the iris in Cogan-Reese syndrome.MethodsA 63-year-old woman was referred for consultation due to diffuse pigmentation of the iris and elevated intraocular pressure (IOP) in the left eye. The clinical examination revealed Cogan-Reese syndrome with pedunculated iris outcroppings on the entire iris surface, and no peripheral anterior synechia. The right eye was normal with normal IOP.ResultsImaging the left iris with the CAM-L cornea lens adapter of the Optovue Fourier-domain OCT (RTVue-OCT) showed a folded iris surface, an increased total iris thickness, and an increased distance between the anterior and ...
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  Mentions: Optovue Optovue RTVue-100 Semmelweis University
14. Choroidal thinning in pseudoexfoliation syndrome detected by enhanced depth imaging optical coherence tomography
  
  Explore eur-j-ophthalmol.com Apr 15 2014 Ophthalmology
  
  PurposeTo measure choroidal thickness in patients with pseudoexfoliation (PEX) syndrome and to compare the values with control eyes using enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsThirty-four patients with PEX syndrome and 30 age- and sex-matched healthy subjects were included in this study. Only one eye of each of the patients was included. Choroidal thickness was measured manually from the outer border of the retinal pigment epithelium to the inner scleral border at the subfovea, 3 mm temporal to the fovea, and 3 mm nasal to the fovea using EDI-OCT.ResultsA total of 34 eyes from 34 consecutive patients with ...
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15. Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography
  
  Explore American Journal of Ophthalmology Apr 15 2014 Ophthalmology
  
  Purpose to distinguish differences in retinal nerve fiber layer (RNFL) thickness and peripapillary total retinal volume between eyes with papilledema, pseudopapilledema, and normal findings. Design Cohort study Methods Forty-two eyes with mild papilledema, 37 eyes with congenitally elevated optic disc (pseudopapilledema), and 34 normal eyes met the inclusion criteria at 1 academic institution (in Iran) and underwent neuro-ophthalmic examination. Spectral-domain optical coherence tomography scans surrounding the optic disc were performed in each eye of patients and subjects. Main outcome measures were mean RNFL thickness and peripapillary total retinal volume measurements (inner and outer rings volumes) that were compared between groups ...
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  Mentions: Johns Hopkins University
16. In vivo analysis of the iris thickness by spectral domain optical coherence tomography
  
  Explore BJO Online Apr 15 2014 Ophthalmology
  
  Purpose To assess the effectiveness of spectral domain optical coherence tomography (SD-OCT) in providing in vivo measurements of iris thickness in healthy and pathological subjects. Methods 14 healthy volunteers and 14 patients with unilateral Fuchs’ uveitis were enrolled in the study. The two groups were comparable for age, gender and race. Each subject underwent complete clinical examination and anterior segment SD-OCT imaging in both eyes. SD-OCT scans of the iris were performed following a cross-sectional pattern. Iris thickness values were obtained using a purposely developed software-based analysis of OCT images. Measurements were carried out twice by two trained independent operators ...
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  Mentions: Mario Cigada University of Milan
17. Cornea characterization using a combined multiphoton microscopy and optical coherence tomography system
  
  Explore opticsinfobase.org Apr 14 2014 Microscopy , Ophthalmology
  
  We present a multimodal imaging system which combines multiphoton microscopy and optical coherence tomography to visualize the morphological structures, and to quantify the refractive index (RI) and thickness of cornea. The morphological similarities and differences at different corneal layers across various species are identified. In the piscine and human corneas, the stromata exhibit thin fibers that indicate an overall collagen direction. Human corneas display collagen micro-folds which cause increased light attenuation. In the murine, porcine and bovine corneas, the stromata show interwoven collagen patterns. The Bowman’s layer and the Descemet’s membrane are also distinguished in some species. The ...
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  Mentions: University of British Columbia
18. Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia
  
  Explore LWW Online Apr 13 2014 Ophthalmology
  
  Purpose of Review To describe the novel spectral-domain optical coherence tomography (SD-OCT) finding of paracentral acute middle maculopathy (PAMM) that can be associated with acute macular neuroretinopathy (AMN) or retinal vasculopathy, and that may indicate an underlying pathogenesis related to ischemia of the retinal deep capillary plexus (DCP). Recent Findings With the advent of high-definition SD-OCT imaging, we are now able to detect deep capillary ischemia. Although cotton wool spots are caused by ischemia of the superficial capillary plexus, PAMM is caused by ischemia of the DCP, and appears as hyper-reflective, band-like lesions in the middle retina, extending from the ...
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19. Optical coherence tomography and visual evoked potentials in healthy persons
  
  Explore Clinical Neurophysiology Apr 12 2014 Neurology , Ophthalmology
  
  Purpose Optical coherence tomography (OCT) and Visual evoked potentials (VEPs) represent non-invasive objective examination of the visual system. While the OCT measures a morphological property of the retina (thickness of the retinal nerve fibre layer – RNFL), the VEP allows assessment a function of the visual system. There are numerous studies describing a mutual involvement of both mentioned aspects in diseases like multiple sclerosis, optic neuritis or glaucoma, however, normative studies of these relationship are missing. In our study we address this issue with an expectation to translate the findings into interpretation of pathological findings. Methods We examined a group of ...
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  Mentions: Heidelberg Engineering Heidelberg Spectralis
20. Structure-Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time Domain and Spectral Domain OCT devices
  
  Explore iovs.org Apr 12 2014 Ophthalmology
  
  Purpose: To examine the structure-function relationship between two perimetric tests, the Frequency-Doubling Technology (FDT) Matrix and Standard Automated Perimetry (SAP), and two Optical Coherence Tomography (OCT) devices (Time-Domain and Spectral-Domain). Methods: This cross-sectional study included 97 eyes from 29 healthy individuals and 68 individuals with early, moderate, or advanced primary open-angle glaucoma. The correlations between overall and sectorial parameters of retinal nerve fiber layer thickness (RNFL) measured with Stratus and Spectralis OCT and the visual field sensitivity obtained with FDT Matrix and SAP were assessed. The relationship was also evaluated using a previously described linear model. Results: The correlation coefficients ...
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  Mentions: Universidade Federal de São Paulo Heidelberg Engineering Carl Zeiss Meditec
21. Optic nerve head assesment: comparison of Cirrus optic coherence tomography and Heidelberg Retinal Tomograph 3
  
  Explore Wiley Online Library Apr 11 2014 Ophthalmology
  
  Background The purpose of this study was to analyze the relationship between Optic Nerve Head (ONH) parameters measured by spectral domain optical coherence tomography and confocal scanning laser ophthalmoscope. Design Prospective, cross-sectional study. Hospital setting. Participants One hundred seventy-three subjects (85 glaucoma and 88 normal subjects). Methods One eye from each individual was selected randomly for ONH imaging by the spectral domain Cirrus OCT and Heidelberg Retinal Tomograph 3 (HRT3). Main Outcome Measures Four ONH parameters that are measured by both technologies (average cup to disc ratio (CDR), rim area, disc area and cup volume) were analyzed and compared for ...
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  Mentions: Heidelberg Engineering Carl Zeiss Meditec University of Sydney
22. Expanding OCT: Quanitifying the Cornea’s Optical Performance
  
  Explore osa-opn.org Apr 11 2014 Ophthalmology
  
  Optical coherence tomography, a well-known method for imaging the retina, may allow physicians to perform quantitative metrology of the eye’s own optics. Swept-source OCT allows for simultaneous imaging of the cornea, iris and retina in living patients. Laser refractive surgeries such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) have brought better vision to tens of millions worldwide. But these techniques also exact a cost: because they work by reshaping the eye’s cornea, they make accurate measurement of the cornea’s optical parameters after surgery unreliable using conventional tools. That’s important, not only because inaccurate ...
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  Mentions: Joseph A. Izatt Duke University
23. UC Davis Receives a NIH Grant for studying Structure and Function of The Chorioretinal Complex in Age-Related Macular Degeneration.
  
  Explore Optical Coherence Tomography News Apr 10 2014 Ophthalmology , Funding
  
  University of California at Davis Receives a 2014 NIH Grant for $563,632 for studying Structure and Function of The Chorioretinal Complex in Age-Related Macular Degeneration. The principal investigator is John Werner. The program began in 2014 and ends in 2019. Below is a summary of the propose work. Three aims are proposed to study the chorioretinal complex (choroid, choriocapillaris, Bruch's membrane, retinal pigment epithelium, photoreceptors) in age-related macular degeneration (AMD). Each aim includes both technical goals involving optical imaging and tests of hypotheses related to the pathogenesis of this disease. Aim 1 will use phase changes between successive ...
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  Mentions: National Institutes of Health John S. Werner UC Davis
24. Correlation between Optic Nerve Parameters Obtained Using 3D Nonmydriatic Retinal Camera and Optical Coherence Tomography: Interobserver Agreement on the Disc Damage Likelihood Scale
  
  Explore Hindawi Publishing Corporation Apr 10 2014 Ophthalmology
  
  Purpose . To compare stereometric parameters obtained by three-dimensional (3D) optic disc photography and optical coherence tomography (OCT) and assess interobserver agreement on the disc damage likelihood scale (DDLS). Methods . This retrospective study included 190 eyes from 190 patients classified as normal, glaucoma suspect, or glaucomatous. Residents at different levels of training completed the DDLS for each patient before and after attending a training module. 3D optic disc photography and OCT were performed on each eye, and correlations between the DDLS and various parameters obtained by each device were calculated. Results . We found moderate agreement (weighted kappa value, 0.59 ± 0 ...
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  Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT
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