Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Association between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography
  
  Explore iovs.org 10 hours, 9 min ago Ophthalmology
  
  Purpose: This study aimed to evaluate an association between hypertension and macular thickness. Methods: Eight hundreds and twenty-seven Korean adults composed of 163 pairs of twins and their family members were included in this population-based cross-sectional study. Macular thickness was measured with optical coherence tomography at nine macular subfields defined by the Early Treatment of Diabetic Retinopathy Study. Cardiometabolic risk factors, including body mass index (BMI), hypertension, diabetes, lipid profiles, and smoking status, were assessed. Linear mixed regression analysis was conducted with consideration of familial correlations and adjustment for covariates. Results: Age-, sex-, and axial length-adjusted analysis showed that systemic ...
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  Mentions: Seoul National University Sungkyunkwan University Samsung
2. Quantitative Analysis of Microdistortions in Bowman's Layer Using Optical Coherence Tomography After SMILE Among Different Myopic Corrections
  
  Explore Healio.com Mar 4 2015 Ophthalmology
  
  PURPOSE: To quantitatively analyze the characteristics of Bowman’s layer microdistortions after femtosecond laser small incision lenticule extraction (SMILE) among different myopic corrections, and their correlations with stromal lenticule thickness. METHODS: In this nonrandomized, prospective, controlled study, 63 eyes of 32 consecutive patients undergoing SMILE were divided into three groups according to the preoperative spherical equivalent (SE): greater than −6.00 D (20 eyes), −3.00 to −6.00 D (26 eyes), and −3.00 D or less (17 eyes). Measurement by slit-lamp microscope, uncorrected distance visual acuity (UDVA), manifest refraction, and Fourier-domain optical coherence tomography (FD-OCT) were conducted preoperatively ...
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  Mentions: Fudan University
3. Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality
  
  Explore Healio.com Mar 4 2015 Ophthalmology
  
  The authors report a new, non-invasive diagnostic method in the diagnosis of retinal cavernous hemangioma (RCH). A 6-year-old girl was referred for a non-clearing retinal hemorrhage of 6 months’ duration. Fourier-domain optical coherence tomography (FD-OCT) showed an intraretinal lesion with cystic-like internal appearance. Optical shadowing was present, preventing establishment of any subretinal component to the lesion. Swept-source OCT (SS-OCT) showed an intraretinal lesion consisting of a group of clearly defined grape-like caverns with overlying preretinal tissue. Wide-field fundus fluorescein angiography (WF-FFA) confirmed the diagnosis of RCH. SS-OCT was superior to FD-OCT in showing the internal anatomy of the RCH and ...
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  Mentions: Topcon Medical Systems University of Manchester Paulo E. Stanga
4. Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography
  
  Explore scielo.br Mar 3 2015 Ophthalmology
  
  Letter to the Editor.
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5. Descemet Membrane Endothelial Keratoplasty: Intraoperative and Postoperative Imaging Spectral-Domain Optical Coherence Tomography
  
  Explore Hindawi Publishing Corporation Mar 3 2015 Ophthalmology
  
  We describe a case report of using the same handheld spectral-domain anterior segment optical coherence tomography (ASOCT) for rapid intraoperative and postoperative imaging in a case of Descemet membrane endothelial keratoplasty (DMEK). A 67-year-old woman, with Fuchs dystrophy and corneal decompensation, underwent DMEK with intraoperative ASOCT imaging using the handheld Envisu spectral domain ASOCT system (Bioptigen, Inc., Morrisville, NC, USA). We found that this easy-to-use portable system with handheld probe allowed for rapid imaging of the anterior segment during donor manipulation to visualize the orientation of the DMEK donor, as well as to confirm the initial adhesion of the DMEK ...
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  Mentions: University College London Bioptigen Singapore Eye Research Institute
6. Retinal development in albinism: a prospective study using optical coherence tomography in infants and young children
  
  Explore TheLancet.com Mar 3 2015 Ophthalmology
  
  Background Retinal development normally involves migration of the inner retinal layers away from the fovea, migration of the cone photoreceptors into the fovea, and elongation of the photoreceptors over time. This process is arrested prematurely in albinism. However, because retinal development continues at least until the age of 4 years, when development arrests in albinism is uncertain. In this study we outlined the time course of retinal development in children with albinism. Methods We studied 44 children with a diagnosis of albinism and 223 control participants. All participants were aged between 0 and 6 years. We obtained 219 mixed cross-sectional ...
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7. Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye
  
  Explore Optical Coherence Tomography News Mar 2 2015 Ophthalmology
  
  The ARVO Special Interest Group meeting on "Optical Coherence Tomography Angiography of the Eye" wwill take place during ARVO 2015 meeting, in Denver Colorado. SIG Session Number: 125 Session Date/Start Time: M ay 3, 2015 from 1:30 PM to 3:00 PM Room: 2C/3C Mile High Ballroom Organizers: David Huang, Philip Rosenfeld, Moderators: Carmen Puliafito, James Fujimoto Participating in the Technology panel: David Huang, Yoshiaki Yasuno, Ruikang Wang, Yali Jia. Clinical panel 1: Phil Rosenfeld, SriniVas Sadda, Jay Duker, Ching-Jygh Chen, Bruno Lumbroso Clinical panel 2: Marco Rispoli, Andre Romano, Richard Rosen, Richard Spaide, Giovanni Staurenghi, Nadia ...
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  Mentions: Carmen A. Puliafito Philip J. Rosenfeld James G. Fujimoto
8. Call for Papers for the 3rd International "En Face" OCT and OCT Angiography Congress, Rome December 11 2015
  
  Explore Optical Coherence Tomography News Mar 2 2015 Ophthalmology
  
  3rd International "En Face" OCT and OCT Angiography Congress will be held in Rome Italy on December 11-12 2015. For more information click HERE .
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  Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto
9. Retinal angiography with real-time speckle variance optical coherence tomography
  
  Explore BJO Online Mar 2 2015 Ophthalmology
  
  This report describes a novel, non-invasive and label-free optical imaging technique, speckle variance optical coherence tomography (svOCT), for visualising blood flow within human retinal capillary networks. This imaging system uses a custom-built swept source OCT system operating at a line rate of 100 kHz. Real-time processing and visualisation is implemented on a consumer grade graphics processing unit. To investigate the quality of microvascular detail acquired with this device we compared images of human capillary networks acquired with svOCT and fluorescein angiography. We found that the density of capillary microvasculature acquired with this svOCT device was visibly greater than fluorescein angiography ...
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  Mentions: University of British Columbia University of Western Australia Marinko V. Sarunic
10. Posterior Vitreous Mobility Delineated by Tracking of Optical Coherence Tomography Images in Eyes with Idiopathic Macular Holes
  
  Explore American Journal of Ophthalmology Mar 1 2015 Ophthalmology
  
  Purpose To demonstrate the posterior vitreous mobility following eye movements in patients forming macular holes, using an optical coherence tomography (OCT) eye tracking system. Design Prospective consecutive interventional case series. Methods Twenty four eyes of seventeen consecutive patients with idiopathic macular hole and the remaining fellow eyes were recruited. Following acquisition of baseline fundus scans, all patients were instructed to perform sets of standardized full excursion, vertical and horizontal eye movements. Immediately after each set of movements an OCT scan registered to the baseline fundus image was obtained using the eye tracking system. Three images were then overlaid using picture-editing ...
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  Mentions: Johns Hopkins University Peter L. Gehlbach
11. Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy
  
  Explore LWW Online Mar 1 2015 Neurology , Ophthalmology
  
  Objective: To analyze the retinal ganglion cell layer (RGL) by optical coherence tomography (OCT) in toxic and nutritional optic neuropathy and to correlate its thickness and volume with functional damage. Methods: We conducted an observational cross-sectional study in healthy subjects and in patients with toxic optic neuropathy observed in the Neuro-Ophthalmology Department of Central Lisbon Hospital Center. Complete ophthalmologic examination, OCT (Heidelberg Spectralis), and automated static perimetry were performed. Thickness and macular volume of RGL layer and inner plexiform layer were measured after manual segmentation. Results: The study included 16 eyes of 12 healthy subjects and 16 eyes of 8 ...
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  Mentions: Heidelberg Spectralis
12. Reply to “Visante Anterior Segment Optical Coherence Tomography Analysis of Morphologic Changes After Deep Sclerectomy With Intraoperative Mitomycin-C and No Implant Use”
  
  Explore LWW Online Mar 1 2015 Ophthalmology
  
  Reply to " Letters to the Editor".
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13. Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System
  
  Explore iovs.org Feb 27 2015 Ophthalmology
  
  Purpose. To evaluate the capability of a novel, coaligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in situ. Methods. Low-amplitude elastic deformations in young and mature rabbit lenses were measured by an US-OCE system consisting of a spectral-domain optical coherence tomography (OCT) system coaligned with a focused ultrasound system used to produce a transient force on the lens surface. Uniaxial compressional tests were used to validate the OCE data. Results. The OCE measurements showed that the maximum displacements of the young rabbit lenses were significantly larger than ...
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  Mentions: Baylor College of Medicine Kirill V. Larin University of Houston
14. En face swept-source optical coherence tomography in neovascular age-related macular degeneration
  
  Explore BJO Online Feb 27 2015 Ophthalmology
  
  Purpose To describe en face swept-source optical coherence tomography (SS-OCT) findings in the retinal pigment epithelium (RPE) and choroid and to correlate them with fluorescein angiography (FA) and/or indocyanine green angiography (ICGA) in neovascular age-related macular degeneration (AMD). Methods Thirty-eight eyes with the recent diagnosis of neovascular AMD were imaged using an SS-OCT system. En face images were obtained at RPE, choriocapillaris, Sattler's layer and Haller's layer level. Analysis of the images and correlation with colour fundus photographs, FA, ICGA in selected cases, were made. Results En face images at RPE level revealed changes in all eyes ...
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  Mentions: Jay S. Duker Tufts University
15. En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells
  
  Explore American Journal of Ophthalmology Feb 27 2015 Ophthalmology
  
  Purpose To characterize perifoveal intraretinal cavities observed around full-thickness macular holes (MH) using en face optical coherence tomography and to establish correlations with histology of human and primate maculae. Design Retrospective non-consecutive observational case series. Methods Macular en face scans of eight patients with MH were analyzed to quantify the areas of hyporeflective spaces, and compared with macular flat-mounts and sections from one normal human donor eye and two normal primate eyes (Macaca fascicularis). Immunohistochemistry was used to study the distribution of glutamine synthetase, expressed by Müller cells, and zonula occludens-1, a tight-junction protein. Results The mean area of ...
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  Mentions: University of Lausanne Maria Cristina Savastano Bruno Lumbroso
16. Comparison of Optical Coherence Tomography Findings in Patients With Primary Open-angle Glaucoma and Parkinson Disease
  
  Explore LWW Online Feb 27 2015 Ophthalmology
  
  Purpose: To evaluate the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex, and macular thickness as well as their correlation with the severity of diseases. Materials and Methods: This is a cross-sectional study and comparing both eyes of 26 patients with primary open-angle glaucoma, 25 patients with Parkinson disease (PD), and 23 healthy subjects. RNFL, ganglion cell complex, and macular thickness were measured and analyzed with optical coherence tomography (OCT) in all cases and correlation with severity of the disease was assessed in PD group. Results: The mean RNFL of PD was significantly thinner compared with controls (P=0 ...
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17. Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects
  
  Explore LWW Online Feb 27 2015 Ophthalmology
  
  Purpose: To elucidate patterns of macular ganglion cell-inner plexiform layer (GCIPL) defects by Cirrus optical coherence tomography (OCT) and examine the spatial relationship between GCIPL defect and visual field (VF) defect patterns. Methods: A total of 116 eyes of 116 normal subjects and 111 eyes of 111 glaucoma patients were included. The 227 study subjects underwent Cirrus OCT imaging in macular cube mode and reliable standard VF testing. Two ophthalmologists blindly classified GCIPL defect patterns and VF defects. The frequency distribution of GCIPL defect patterns and spatial relationships between GCIPL defects and VF defects were investigated. Results: GCIPL defect patterns ...
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  Mentions: Zeiss Cirrus HD-OCT Chan Yun Kim Na Rae Kim
18. Optical Coherence Tomography versus Visual Evoked Potentials in detecting subclinical visual impairment in multiple sclerosis
  
  Explore Journal of medicine and life Feb 27 2015 Neurology , Ophthalmology
  
  Rationale . Visual impairment is one of the most common clinical manifestations of multiple sclerosis (MS). Some multiple sclerosis patients complain of poor vision although the Snellen visual acuity is 20/20. This study reveals that sensitive measurements like visual evoked potential (VEP) and optical coherence tomography (OCT) can evidence subclinical disturbances of visual pathway. These methods examine the relation between the visual function (VEP) and retinal nerve fiber layer (RNFL) thickness, as a structural biomarker for axonal loss in patients with multiple sclerosis (MS). The findings in this study indicate the utility of combining structural and functional testing in clinical ...
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19. NASA presents Heidelberg Engineering the NASA Certificate of Appreciation
  
  Explore Optical Coherence Tomography News Feb 26 2015 Ophthalmology
  
  Heidelberg Engineering was honored today by visitors from NASA. The guests from NASA: Dr. Christian Otto, Lead Scientist for the Vision Impairment and Intracranial Pressure (VIIP) project ; Dr. Steven Hart, lead flight surgeon for VIIP ; Rachel Brady, VIIP Science Coordinator; and Jennifer Villarreal, Project Manager came for a ceremony to present Heidelberg Engineering with the NASA Certificate of Appreciation in recognition of Heidelberg Engineering’s support in placing a SPECTRALIS ® OCT system on the International Space Station (ISS). During the ceremony, the NASA guests described the physiological challenges encountered with long duration space flight and the research underway to understand ...
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  Mentions: Heidelberg Engineering Heidelberg Spectralis
20. Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes
  
  Explore 欢迎访问国际眼科杂志编辑部 Feb 26 2015 Ophthalmology
  
  AIM: To assess the reproducibility of Cirrus high-definition optical coherence tomography (HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) for analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes METHODS: Forty-five eyes (one eye from each glaucomatous patient) were imaged with Cirrus HD-OCT. Each eye was imaged three times by two separate operators. Intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest variability were evaluated for both intraobserver and interobsever measurements RESULTS: In intraobserver measurements, the average RNFL thickness ICC was 0.983. CV and test-retest variability were 2.3% and 4.4 μm respectively. In quadrants ...
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  Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT
21. Quantitative Analysis of Microdistortions in Bowman’s Layer Using Optical Coherence Tomography After SMILE Among Different Myopic Corrections
  
  Explore Ow.ly Feb 25 2015 Ophthalmology
  
  PURPOSE: To quantitatively analyze the characteristics of Bowman’s layer microdistortions after femtosecond laser small incision lenticule extraction (SMILE) among different myopic corrections, and their correlations with stromal lenticule thickness. . METHODS: In this nonrandomized, prospective, controlled study, 63 eyes of 32 consecutive patients undergoing SMILE were divided into three groups according to the preoperative spherical equivalent (SE): greater than −6.00 D (20 eyes), −3.00 to −6.00 D (26 eyes), and −3.00 D or less (17 eyes). Measurement by slit-lamp microscope, uncorrected distance visual acuity (UDVA), manifest refraction, and Fourier-domain optical coherence tomography (FD-OCT) were conducted preoperatively ...
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  Mentions: Fudan University
22. Compare the effects of two silicone-hydrogel bandage contact lenses on epithelial healing after photorefractive keratectomy with anterior segment optical coherence tomography
  
  Explore Contact Lens & Anterior Eye Feb 24 2015 Ophthalmology
  
  $Compare the effects of two silicone-hydrogel bandage contact lenses on epithelial healing after photorefractive keratectomy with anterior segment optical coherence tomography$
  Purpose To evaluate the efficacy of two silicone hydrogel bandage lenses (SiHy) on epithelial healing following photorefractive keratectomy (PRK) with anterior segment optical coherence tomography (AS-OCT). Methods Forty-two eyes of 21 patients who underwent PRK were included in a contralateral eye comparison study. At the end of the procedure, one eye of each patient was fitted with a Lotrafilcon B contact lens whereas the fellow eye was fitted with a Comfilicon A lens. Patients were examined on the day of surgery and at days 1–5 postoperatively. Main outcome measures were number of reepithelialized eyes, epithelial defect size, patient discomfort ...
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  Mentions: Sevil Karaman Erdur
23. Changes in choroidal thickness during pregnancy detected by enhanced depth imaging optical coherence tomography
  
  Explore BJO Online Feb 24 2015 Ophthalmology
  
  Aim To compare the choroidal thickness measurements of healthy pregnant women obtained in the first trimester with measurements obtained in the third trimester using enhanced depth imaging optical coherence tomography (OCT). Methods 54 eyes of 27 healthy pregnant women and 50 eyes of 25 age matched healthy women were enrolled in this observational, cross-sectional study. The pregnant women underwent two OCT scans, one in the first trimester at gestational weeks 6–8, and the other during the third trimester at gestational weeks 32–37; the control group had OCT scanning during the follicular phase of the menstrual cycle, using the ...
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24. Fourier-Domain Optical Coherence Tomography for Monitoring the Lower Tear Meniscus in Dry Eye after Acupuncture Treatment
  
  Explore Hindawi Publishing Corporation Feb 24 2015 Ophthalmology
  
  Dry eye is highly prevalent and has a significant impact on quality of life. Acupuncture was found to be effective to treat dry eye. However, little was known about the effect of acupuncture on different subtypes of dry eye. The objective of this study was to investigate the applicability of tear meniscus assessment by Fourier-domain optical coherence tomography in the evaluation of acupuncture treatment response in dry eye patients and to explore the effect of acupuncture on different subtypes of dry eye compared with artificial tear treatment. A total of 108 dry eye patients were randomized into acupuncture or artificial ...
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  Mentions: Fudan University
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