Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies
  
  Explore ScienceDirect 23 hours, 56 min ago Ophthalmology
  
  The use of optical coherence tomography to diagnose conditions that predominantly affect the photoreceptor layer is postulated as a technique that allows to evaluate the relationship between retinal changes and loss of visual acuity. Two clinical cases are presented on patients with a bilateral decrease of their visual acuity and alteration in chromatic perception. Optical coherence tomography revealed subfoveal focal hypo-reflective defects on the hyper-reflective band (known as the ellipsoid zone).
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2. Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players
  
  Explore Home - ClinicalTrials.gov May 21 2019 Neurology , Ophthalmology , Clinical Trials
  
  The main hypothesis is that exposure to repeated shocks is associated with a greater decrease in the thickness of optical nerve fibres. In order to show a association between the occurrence of concussions (in number and severity) and the variation in the thickness of the retinal nerve fibre layer, all participating rugby players will have an ophthalmologic examination (OCT and (retinophotography) at the beginning and end of the Rugby season.
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3. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study
  
  Explore Wiley Online Library May 18 2019 Neurology , Ophthalmology
  
  Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected in a subset ...
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  Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer
4. Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study
  
  Explore Journal of AAPOS May 18 2019 Ophthalmology
  
  Purpose To evaluate optical coherence tomographic angiography (OCTA) findings on retinal microcirculation in hyperopic anisometropic amblyopia compared with fellow eyes and nonamblyopic control eyes. Methods A total of 40 pediatric patients with hyperopic anisometropic amblyopia and 57 control subjects were recruited, and 137 eyes (40 amblyopic, 40 fellow, and 57 control eyes) were evaluated. Data on best-corrected visual acuity (logMAR), axial length (mm), refractive error, and OCTA findings (foveal avascular zone parameters, macular vascular density in superficial and deep retinal capillary plexus, central macular thickness) were recorded in amblyopic, fellow, and control eyes. Results Compared with fellow and control eyes ...
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5. Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes
  
  Explore OSA | OSA Publishing May 17 2019 Ophthalmology
  
  Imaging choriocapillaris (CC) is a long-term challenge for commercial OCT angiography (OCTA) systems due to limited transverse resolution. Effects of transverse resolution on the visualization of a CC microvascular network are explored and demonstrated in this paper. We use three probe beams with sizes of ~1.12 mm, ~2.51 mm and ~3.50 mm at the pupil plane, which deliver an estimated transverse resolution at the retina of 17.5 µm, 8.8 µm and 7.0 µm, respectively, to investigate the ability of OCTA to resolve the CC capillary vessels. The complex optical microangiography algorithm is applied to ...
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  Mentions: University of Washington Ruikang K. Wang University of Dundee
6. Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos
  
  Explore Home - Springer May 16 2019 Ophthalmology
  
  Purpose To describe swept source-OCT (SS-OCT) and swept source-OCT angiography (SS-OCTA) findings in eyes with posterior microphthalmos (PM). Methods Twelve eyes (six patients) with PM were evaluated using SS-OCT and SS-OCTA. Structural changes, subfoveal choroidal thickness (SFCT), and perifoveal capillary changes with qualitative and quantitative assessments were analyzed. Twenty eyes served as control group. Results SS-OCT findings included elevated retinal papillo-macular fold (75%), retinal pigment epithelium folds (83%), macular cystoid spaces (42%), subretinal fluid (17%), and increased visibility of posterior vitreous cortex and hyaloid (42%). Mean SFCT in PM and in control eyes were 430.33 ± 157.48 µm and ...
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  Mentions: University of Perugia
7. Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography
  
  Explore Home - Springer May 16 2019 Ophthalmology
  
  Purpose To investigate potential changes of vessel density (VD) at the optic nerve head (ONH) and the macula 6 months after trabeculectomy (TE). Methods In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE + MMC (mitomycin C). At four different time points multiple morphological papillary parameters were measured by OCT, and the ONH VD in the radial peripapillary capillary layer and the superficial and deep plexuses of the macula was determined by OCTA (optical coherence tomography angiography, RTVue-XR, Optovue). The mean defect was determined by visual field examination (mode 30-2, Humphrey Field Analyzer). The duration of ...
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  Mentions: Optovue Optovue RTVue-100 University of Lübeck
8. Anterior Segment Optical Coherence Tomography Images in Microsporidial Keratoconjunctivitis
  
  Explore LWW Online May 16 2019 Ophthalmology
  
  Purpose: To describe the findings of anterior segment optical coherence tomography (AS-OCT) in patients with microsporidial keratoconjunctivitis . Methods: The observational study included 13 eyes from 13 patients. Slit-lamp photography and AS-OCT were performed using the Swept source OCT before corneal scraping . All cases were positive for Gram-chromotrope (modified trichrome) staining for Microsporidia spp. Results: Three significant AS-OCT findings were observed. First, hyperreflective dots were limited to the epithelial layers of the cornea, and second, there were no extensions into the stromal layer in all cases. Last, hyperreflective dots slightly raised above the epithelial surface were observed in most cases (12 ...
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9. Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography
  
  Explore SAGE Journals May 16 2019 Ophthalmology
  
  Differential artery–vein analysis is valuable for early detection of diabetic retinopathy and other eye diseases. As a new optical coherence tomography imaging modality, optical coherence tomography angiography provides capillary level resolution for accurate examination of retinal vasculatures. However, differential artery–vein analysis in optical coherence tomography angiography particularly for macular region in which blood vessels are small is challenging. In coordination with an automatic vessel tracking algorithm, we report here the feasibility of using near infrared optical coherence tomography oximetry to guide artery–vein classification in optical coherence tomography angiography of macular region. Impact statement It is known that ...
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  Mentions: Xincheng Yao
10. Four-Dimensional Microscope-Integrated Optical Coherence Tomography Guidance in a Model Eye Subretinal Surgery
  
  Explore LWW Online May 16 2019 Ophthalmology
  
  Macular-degeneration related atrophy...
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  Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
11. Curvilinear branching retinal deposits in acute syphilitic posterior placoid chorioretinitis: a novel pattern on en‐face optical coherence tomography
  
  Explore Wiley Online Library May 16 2019 Ophthalmology
  
  Letter to the Editor
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12. Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients
  
  Explore Nature Publishing Group May 16 2019 Ophthalmology
  
  Background To analyze the optical coherence tomography (OCT) characteristics and visual outcome of vitrectomy in myopic foveoschisis (MF) patients and identify prognostic factors. Methods This study is a retrospective clinical cohort study in tertiary care hospital. Thirty-two eyes of 32 patients who underwent MF-related vitrectomy in were investigated retrospectively. Best-corrected visual acuity (BCVA) measured at 1 year post surgery and changes in central foveal thickness (CFT) and co-existing macular pathologies, such as foveal detachment (FD), lamellar holes, and macular holes were the main outcome measures. Prognostic factors were identified using multivariate linear regression analysis. Results Average BCVA (in logarithm of ...
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  Mentions: Yonsei University
13. Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC) (OPACITY)
  
  Explore Home - ClinicalTrials.gov May 15 2019 Ophthalmology , Clinical Trials
  
  Optical Coherence Tomography Angiography (OCT-A) is a noninvasive imaging technique that allows one to see blood vessels in the retina. The investigating team used this approach in patients with acute, recurrent and persistent subtypes of Central Serous Chorioretinopathy (CSC) to check for possible Choriocapillaris hypoperfusion. The presence or absence of these microvascular changes was explored in both eyes of the patients and compared to a control group of healthy volunteers. The possibility of a correlation between Choriocapillaris flow deficits, age and spontaneous resolution of serous retinal detachment was also evaluated. This study was conducted in an effort to improve one ...
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14. Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system
  
  Explore Optical Coherence Tomography News May 15 2019 Ophthalmology , Other Business News
  
  Ping An Insurance (Group) Company of China, Ltd. is pleased to announce that its technology arm, Ping An Technology, has completed a prospective multi-center clinical trial for the world's first intelligent optical coherence tomography (OCT) retinal disease screening system. The screening system is jointly developed by Ping An Technology and US-based Optovue, Inc. It is the first artificial intelligence (AI) imaging and screening system in the world that seamlessly integrates an OCT retinal imaging device and AI lesion detection software. The clinical trial was conducted at three well-known research institutions, the Eye and ENT Hospital of Fudan University in ...
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  Mentions: Optovue Shanghai Jiao Tong University
15. Projection resolved optical coherence tomography angiography to distinguish flow signal in retinal angiomatous proliferation from flow artifact
  
  Explore Journals | PLOS May 15 2019 Ophthalmology
  
  Purpose To investigate whether hyperreflective foci (HRF) exhibit flow projection artifact on OCTA, and study the efficacy of commercial projection artifact removal software (PAR-OCTA, Optovue, Inc), and a custom projection resolved OCTA (PR-OCTA) in distinguishing artifacts from true flow in retinal angiomatous proliferation (RAP). Methods The study included five eyes with HRF representing pigment migration in dry age-related macular degeneration (AMD), five eyes with leaking treatment- naïve RAP, and ten eyes with diabetic hard exudates. We examined flow signal on OCTA cross-sections using PAR, and performed PR-OCTA to study the effect of increasingly stringent projection removal thresholds. Flow signal ...
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  Mentions: National Institutes of Health Optovue Northwestern University
16. Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma
  
  Explore American Journal of Ophthalmology May 15 2019 Ophthalmology
  
  Purpose To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images. Design Prospective, cross-sectional study. Methods Thirty-four patients with primary open-angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain AS-OCTA images of the corneal limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The vessel density ...
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  Mentions: Akitaka Tsujikawa Kyoto University Graduate School of Medicine Tadamichi Akagi
17. Laser-based technology helps doctors image full eye in 3-D
  
  Explore PhysOrg.com May 14 2019 Ophthalmology
  
  It is estimated that in 2015, 217 million people had moderate to severe vision impairment, while 36 million were blind, according to an article in the journal The Lancet Global Health. The World Health Organization predicts that about 80 % of vision impairment globally is preventable or curable. Early diagnosis is crucial for effective interventions.
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  Mentions: Technical University of Denmark (DTU) OCTLIGHT
18. Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling
  
  Explore Home (World Scientific) May 14 2019 Ophthalmology
  
  Changes of retinal blood vessel calibers may reflect various retinal diseases and even several non-retinal diseases. We propose a new method to estimate retinal vessel calibers from 3D optical coherence tomography angiography (OCTA) images based on 3D modeling using superellipsoids. Taking advantage of 3D visualization of the retinal tissue microstructures in vivo provided by OCTA, our method can detect retinal blood vessels precisely, estimate their calibers reliably, and show the relative flow speed visually.
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  Mentions: Massachusetts General Hospital Harvard University Wang Yuhl Oh
19. Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence
  
  Explore TVST Journal May 14 2019 Ophthalmology
  
  Purpose : Advanced imaging is increasingly important in the diagnosis of ocular surface malignancy. Inverse spectroscopic optical coherence tomography (ISOCT) and two-photon autofluorescence microscopy (2P-AF) are emerging techniques capable of quantifying ultrastructural and metabolic changes, respectively. We aimed to detect malignancy in ocular surface lesions using ISOCT and 2P-AF. Methods : Portions of excised specimens from patients undergoing conjunctival biopsy at Boston Medical Center were imaged by ISOCT and/or 2P-AF, and submitted for histologic diagnosis. Lesions were categorized as malignant, premalignant (with dysplasia) or benign. ISOCT and 2P-AF findings were compared between categories. Results : Fourteen specimens from 13 patients were collected ...
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  Mentions: Boston University Ji Yi
20. Analysis of Retinal Perfusion in Children, Adolescents, and Young Adults with Type 1 Diabetes Using Optical Coherence Tomography Angiography
  
  Explore Hindawi Publishing Corporation May 14 2019 Ophthalmology
  
  We performed a cross-sectional study to analyze the retinal vasculature in children, adolescent, and young adults with type 1 diabetes using optical coherence tomography angiography (OCTA). Patients underwent funduscopic examination for diabetic retinopathy (DR) screening during an annual visit for the screening of diabetes-related complications which included the evaluation of glycated hemoglobin (HbA1c), microalbuminuria, lipid profile, arterial pressure, and neurological assessment. In addition, OCTA of the retinal vasculature was performed. Quantitative analysis of the OCTA images evaluated the vessel density at the superficial (SCP) and deep (DCP) capillary plexus of the retina. Structural vascular alterations were evaluated qualitatively. Results were ...
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  Mentions: University of Sydney University of Milan
21. Optical coherence tomography findings in chronic progressive external ophthalmoplegia
  
  Explore LWW Online May 14 2019 Ophthalmology
  
  Background: Chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial encephalomyopathy caused by multiple mtDNA abnormalities. There is little information about the changes of ocular fundus with CPEO. The aim of this work was to measure and evaluate changes in the macular retinal thickness and optic nerve head in patients with CPEO using spectral-domain optical coherence tomography and to compare the findings with those of healthy individuals. Methods: Totally, 18 CPEO patients were enrolled in this study. Healthy volunteers matched for gender, age, and diopter settings were included as a control group. The retinal thickness of macular central fovea, inner and ...
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  Mentions: Peking University
22. Geometrical characterization of the corneo-scleral transition in normal patients with Fourier domain optical coherence tomography
  
  Explore Home - Springer May 14 2019 Ophthalmology
  
  Purpose To characterize the geometry at the corneo-scleral transition for a normal population and its correlation with other anatomic parameters of the eyeball. Methods Transversal epidemiologic study on a sample of 100 individuals (right eye) in different ethnic groups (Africans and Caucasians). All of them were examined with Fourier domain optical coherence tomography, auto-refractometer, topographer, and biometer to obtain the corneo-scleral angle (CSA) and additional clinical parameters. The dataset was analyzed to determine correlations between different anatomical parameters and nasal (CSAn) and temporal CSA (CSAt) values. Results The CSAt presents a significant but low correlation with the anterior chamber depth ...
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23. Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography
  
  Explore OSA | OSA Publishing May 14 2019 Ophthalmology
  
  Many different parameters exist for the investigation of tear film dynamics. We present a new tear meniscus segmentation algorithm which automatically extracts tear meniscus area (TMA), height (TMH), depth (TMD) and radius (TMR) from UHR-OCT measurements and apply it to a data set including repeated measurements from ten healthy subjects. Mean values and standard deviations are 0.0174 ± 0.007 mm 2 , 0.272 ± 0.069 mm, 0.191 ± 0.049 mm and 0.309 ± 0.123 mm for TMA, TMH, TMD and TMR, respectively. A significant correlation was found between all respective tear meniscus parameter pairs (all p < 0 ...
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  Mentions: Medical University of Vienna Singapore Eye Research Institute Angelika Unterhuber
24. Subtractive en face optical coherence tomography imaging
  
  Explore uspto.gov May 14 2019 Ophthalmology , Patents
  
  En face or 3D volumetric OCT imaging during ophthalmic surgery may be performed with an OCT scanning controller that interfaces to an OCT scanner used with a surgical microscope. The OCT scanner may generate en face images before and after surgical operations, such as retinal membrane peeling, are performed. Using digital subtraction on the en face images, an overlay image indicative of the changes from the surgical operations to the eye may be generated and overlaid onto an optical image displayed to a user of the surgical microscope.
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  Mentions: Lingfeng Yu
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