Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Optical Coherence Tomography Angiography Evolution of Choroidal Neovascular Membrane in Choroidal Rupture Managed by Intravitreal Bevacizumab
  
  Explore Hindawi Publishing Corporation Jan 12 2019 Ophthalmology
  
  Purpose . To describe a case of a 25-year-old man with choroidal neovascularization (CNV) secondary to traumatic choroidal rupture treated with intravitreal bevacizumab and to evaluate the vascular structure of the area near the traumatic choroidal rupture. Methods . The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity (BCVA), intraocular pressure, anterior segment and funds examination, and optical coherence tomography angiography (OCTA) at baseline and on each follow-up visit. Fluorescein angiography (FA) was performed at baseline. Intravitreal bevacizumab was administered at the time of choroidal neovascular membrane diagnosis. Results . At baseline, ophthalmoscopic examination of the left eye revealed four subretinal macular ...
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2. Macular colobomata: Comparison of clinical and optical coherence tomography features with serological result
  
  Explore ScienceDirect Jan 12 2019 Ophthalmology
  
  Purpose To assess the correlation between the morphological features and serology in eyes with macular colobomata (MC). Design Retrospective comparative case series Methods Setting: Institutional Study population Patients presenting with MC to the retina clinic over a period of two years (January 2016 to December 2017) Interventional/Observational procedure: Color fundus and swept source optical coherence tomography (SS-OCT, Topcon Inc.) features were reviewed and assessed in three groups based on the serum IgG results: positive for Toxoplasma, positive for Cytomegalovirus (CMV), and serology negative. Main outcome measure Morphological features on clinical and OCT-based examination Results A total of 49 eyes ...
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  Mentions: Topcon Medical Systems
3. Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy
  
  Explore Home - Springer Jan 12 2019 Ophthalmology
  
  Purpose To concurrently evaluate the effect of half-fluence photodynamic therapy (hf PDT) on choriocapillaris (CC) perfusion and choroidal structure in chronic central serous chorioretinopathy (CSC). Methods This prospective study included 48 eyes of 41 patients with chronic CSC. Enhanced depth imaging optical coherence tomography and optical coherence tomography angiography (OCTA) images were analyzed. Choroidal area (CA), luminal area (LA), and stromal area (SA) were computed using Image J software. Results One month after hf-PDT, total CA decreased to 1.312 mm 2 from 1.490 mm 2 ( p < 0.001), LA decreased to 0.981 mm 2 from 1.097 ...
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4. Comparison of retinal nerve fiber layer thickness between normal population and patients with diabetes mellitus using optical coherence tomography
  
  Explore Pakistan Journal of Medical Sciences Jan 12 2019 Ophthalmology
  
  Objective: To compare the difference in peripapillary Retinal Nerve Fibre Layer (RNFL) thickness between normal population and Type-II diabetic patients without diabetic retinopathy using Spectral Domain Optical Coherence Tomography (SD OCT). Methods: This cross sectional study was carried out at PNS Shifa Naval Hospital, from May 2017 to November 2017. Out of 200 eyes, 100 eyes were of normal individuals and 100 eyes were of Type-II diabetic patients without diabetic retinopathy. Both groups were age and gender matched. Average RNFL thickness, along with RNFL of each quadrant of individuals was noted using SD OCT, and compared between two groups. Results ...
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5. Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease
  
  Explore Home - Springer Jan 12 2019 Ophthalmology
  
  Purpose Automated spectral domain optical coherence tomography (SD-OCT) segmentation algorithms currently do not perform well in segmenting individual intraretinal layers in eyes with Stargardt disease (STGD). We compared selective B-scan segmentation strategies for generating mean retinal layer thickness and preserved area data from SD-OCT scans in patients with STGD1. Methods Forty-five eyes from 40 Stargardt patients were randomly selected from the ongoing Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) study. All eyes underwent SD-OCT using a standard macular volume consisting of 1024 × 49 equally spaced B-scans within a 20 × 20 degree field centered on the ...
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  Mentions: Johns Hopkins University University College London Hendrik P. N. Scholl
6. Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment
  
  Explore Home - Springer Jan 12 2019 Ophthalmology
  
  Purpose To detect pre- and postoperative retinal changes in fundus autofluorescence (AF) and spectral domain optical coherence tomography (SD-OCT) and to correlate these with functional outcome in patients with primary rhegmatogenous retinal detachment (RRD). Methods A prospective, 30-month study of patients operated with 25-gauge vitrectomy for primary RRD. Patients were examined preoperatively and after 6 and 30 months, using ultrawide-field AF images (UWFI) (Optos 200Tx) and SD-OCT (Topcon 3D OCT-2000) imaging. Results Of 84 patients (84 eyes) included at baseline, 100.0 and 86.9% were re-examined at month 6 and 30, respectively. Preoperative findings such as macular attachment, detachment ...
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  Mentions: Topcon Medical Systems Optos Topcon 3D OCT-2000
7. Anterior segment optical coherence tomography and its clinical applications: a review
  
  Explore Wiley Online Library Jan 12 2019 Ophthalmology
  
  Anterior segment optical coherence tomography (AS‐OCT) has become one of the cornerstones of non‐contact imaging modalities for assessing such structures as the cornea, anterior chamber angle, aqueous outflow pathway, sclera, and ocular surface structures. As such, it has a broad range of clinical applications, which have been independently reported in the literature. This paper aims to present a review of extant literature on the utility of AS‐OCT and its efficacy in clinical applications, and to evaluate the quality of available evidence. The following databases were searched from inception to 24 June 2018: Medline via Ovid, Cochrane Central ...
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8. Internal Limiting Membrane and Macular Hole
  
  Explore Home - ClinicalTrials.gov Jan 10 2019 Ophthalmology , Clinical Trials
  
  Observational study of Internal Limiting Membrane peeled in macular Hole surgery and studied by Transmission electronic Microscopy (TEM) and Optical Coherence Tomography (OCT) findings in closed holes.
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9. Optical Coherence Tomography Angiography Study for Evaluation of Microvascular Changes in the Subclinical Diabetic Retinopathy
  
  Explore ejhm.journals.ekb.eg Jan 10 2019 Ophthalmology
  
  Background: diabetic retinopathy is the specific microvascular complication of diabetes mellitus and affects 1 of 3 with DM. DR remains a leading cause of vision loss in working adult population. Patients with severe levels of DR were reported to have poor quality of life and reduced physical, emotional and social well-being, and they utilize more health care resources. Objective: this study aimed to evaluate the vascular density, perfusion density and foveal avascular parameters changes in subjects with diabetes mellitus showing no manifestations of diabetic retinopathy using optical coherence tomography angiography. Methods: 40 subjects were categorized into two groups, group A ...
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10. ASYMPTOMATIC MULTIFOCAL PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH JUVENILE DERMATOMYOSITIS OPTICAL COHERENCE ANGIOGRAPHY FINDINGS
  
  Explore LWW Online Jan 10 2019 Ophthalmology
  
  Purpose: To describe a unique presentation of multifocal paracentral acute middle maculopathy in a young patient with juvenile dermatomyositis including optical coherence tomography angiography findings. Methods: Retrospective single case report. Patient: Seventeen-year-old male patient with a history of juvenile dermatomyositis presented for routine hydroxychloroquine screening. Results: Optical coherence tomography revealed undulations of the outer retinal layers and retinal thinning near the fovea in both eyes. Optical coherence tomography angiography revealed loss of flow void densities in the superficial and deep capillary plexi in both eyes. These findings were consistent with a diagnosis of paracentral acute middle maculopathy . Conclusion: To the ...
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11. Macular colobomata: Comparison of clinical and optical coherence tomography features with serological results
  
  Explore American Journal of Ophthalmology Jan 9 2019 Ophthalmology
  
  Purpose To assess the correlation between the morphological features and serology in eyes with macular colobomata (MC). Design Retrospective comparative case series Methods Setting: Institutional Study population Patients presenting with MC to the retina clinic over a period of two years (January 2016 to December 2017) Interventional/Observational procedure: Color fundus and swept source optical coherence tomography (SS-OCT, Topcon Inc.) features were reviewed and assessed in three groups based on the serum IgG results: positive for Toxoplasma, positive for Cytomegalovirus (CMV), and serology negative. Main outcome measure Morphological features on clinical and OCT-based examination Results A total of 49 eyes ...
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  Mentions: Topcon Medical Systems
12. Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography
  
  Explore American Journal of Ophthalmology Jan 9 2019 Ophthalmology
  
  Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Design A prospective, cross-sectional study. Methods Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX ® Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1 mm circle (C 1 ), 1 ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Washington
13. Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2
  
  Explore Home - Springer Jan 8 2019 Ophthalmology
  
  Purpose To evaluate the retinal and choroidal vascular changes through optical coherence tomography angiography (OCTA) in patients with macular telangiectasia type 2 (MacTel 2). Methods Our study included 20 patients (40 eyes) with MacTel 2, and age-matched and sex-matched 18 subjects (36 eyes) in the control group. Fundus color photographs, fundus autofluorescence, fundus fluorescein angiography, spectral-domain optical coherence tomography and OCTA were performed. Foveal vascular density and parafoveal vascular density (PFVD), and foveal retinal thickness and parafoveal retinal thickness, choroidal thickness (CT) and retinal ganglion cell–inner plexiform layer (GCIPL) were compared between MacTel 2 patients and normal age-matched controls ...
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14. Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography in Idiopathic Intracranial Hypertension
  
  Explore LWW Online Jan 8 2019 Neurology , Ophthalmology
  
  Background: Although alterations in the peripapillary retinal nerve fiber layer (RNFL) in patients with idiopathic intracranial hypertension (IIH) have been characterized using optical coherence tomography (OCT), there are little data regarding the peripapillary vasculature in this patient population. Our aim was to evaluate findings of OCT angiography (OCT-A) in the peripapillary region in addition to the RNFL measurements on OCT in patients with IIH. Methods: Thirty-eight eyes of 19 patients with IIH and 42 eyes of 21 healthy controls were enrolled in our study. Papilledema was graded according to the Frisen scale. Peripapillary RNFL and vessel density were evaluated with ...
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15. Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy
  
  Explore BJO Online Jan 8 2019 Ophthalmology
  
  Aim To describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR). Methods This was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central ...
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  Mentions: Northwestern University University of Bern
16. Assessment of Postoperative Morphologic Retinal Changes by Optical Coherence Tomography in Recipients of an Electronic Retinal Prosthesis Implant
  
  Explore The JAMA Network Jan 8 2019 Ophthalmology
  
  Importance The postoperative retinal changes at the interface between an implant electrode array and the retina and whether these anatomic changes have an association with the patient visual performance are unknown. Objective To report morphologic changes in recipients of an Argus II Retinal Prosthesis. Design, Setting, and Participants This consecutive, noncomparative case series study included a retrospective review of the preoperative and postoperative optical coherence tomography of 33 eyes among 33 individuals who underwent Argus II Retinal Prosthesis System implantation between October 28, 2011, and June 8, 2017, at 2 different centers, by the same surgeon (S.R.). Thirteen patients ...
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  Mentions: University of Miami
17. Choroidal thickness and vascular density in macular telangiectasia type 2 using enface swept-source optical coherence tomography
  
  Explore BJO Online Jan 8 2019 Ophthalmology
  
  Purpose To investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT). Methods Prospective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Fundus photography, confocal blue reflectance, near-infrared reflectance, autofluorescence, fluorescein angiography, spectral domain OCT and SS-OCT were performed. Images were independently analysed by two graders, and CVD was calculated from binarised en face SS-OCT images. CT was obtained from the SS-OCT platform via built-in automated segmentation. Multilevel mixed-effects models were ...
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  Mentions: Harvard University Massachusetts Eye and Ear Infirmary University of Coimbra
18. Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography
  
  Explore IOVS Journal Jan 8 2019 Ophthalmology
  
  Purpose : There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanical assessment have various drawbacks: dependence on IOP, long acquisition times, or limited resolution. Here, we present a method that may avoid these limitations by using optical coherence tomography (OCT) to detect the endogenous random motion within the cornea, which can be associated with stromal crosslinking. Methods : Phase-decorrelation OCT (PhD-OCT), based in the theory of dynamic light scattering, is a ...
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  Mentions: Andrew M. Rollins Case Western Reserve University Michael W. Jenkins
19. Plaque characteristics and slow flow during percutaneous coronary intervention of irregular protrusion by optical coherence tomography
  
  Explore Home - Springer Jan 8 2019 Ophthalmology
  
  Irregular protrusion on optical coherence tomography (OCT) is associated with clinical events and target lesion revascularization. We investigated clinical and procedure characteristics, plaque characteristics, slow flow after stent implantation, and clinical outcomes with irregular protrusion using OCT. Eighty-four lesions in 76 patients undergoing OCT before percutaneous coronary intervention were evaluated. Irregular protrusion was defined as protrusion of material with an irregular surface into the lumen between stent struts with a maximum height of ≥100 μm. Lesions with irregular protrusion were found in 56% (47/84). Compared with lesions without irregular protrusion, those with irregular protrusion had significantly higher low-density lipoprotein ...
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20. Analyzing the impact of glaucoma on the macular architecture using spectral-domain optical coherence tomography
  
  Explore Journals | PLOS Jan 8 2019 Ophthalmology
  
  Purpose Using spectral domain optical coherence tomography (SD-OCT) the retina can be segmented automatically to visualize all retinal layers. In glaucoma chronically elevated intraocular pressure leads to a decline of retinal ganglion cells (RGC) which changes retinal architecture. The goal of these analyses was to gain insight into the changes induced by glaucoma within all macular layers using SD-OCT within a closely circumscribed glaucoma cohort. Materials and methods SD-OCT measurements with automated retinal layer segmentation were performed in both eyes of primary open-angle glaucoma patients with a defined monocular absolute visual field scotoma in the central 10° of the visual ...
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  Mentions: University of Leipzig
21. Intraoperative Optical Coherence Tomography–Guided Femtosecond Laser–Assisted Deep Anterior Lamellar Keratoplasty
  
  Explore LWW Online Jan 8 2019 Ophthalmology
  
  Purpose: To describe the feasibility and outcomes of intraoperative optical coherence tomography (OCT)–guided, femtosecond laser –assisted deep anterior lamellar keratoplasty in which the lamellar and tunnel cuts were completed by laser. Methods: The Ziemer Z8 system was used to scan the corneas intraoperatively and guide the stromal lamellar and tunnel cuts created by the laser. Thirty porcine eyes and 3 human cadaver globes were used to evaluate the accuracy of laser-created intrastromal tunnels and the feasibility of achieving big-bubble pneumatic dissection. The tunnel distance above the Descemet membrane ( D t-dm ) was set at 100 and 130 μm, and the ...
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  Mentions: Singapore Eye Research Institute Jodhbir S. Mehta
22. Saving sight: Using AI to diagnose diabetic eye disease
  
  Explore EurekAlert! Jan 8 2019 Ophthalmology
  
  Researchers have used artificial intelligence to support the instant diagnosis of one of the top causes of blindness, diabetes-related eye disease, in its earliest stages. Diabetic retinopathy is the leading cause of vision loss in adults* and its impact is growing worldwide, with 191 million people set to be affected by 2030**. There are no early-stage symptoms and the disease may already be advanced by the time people start losing their sight. Early diagnosis and treatment can make a dramatic difference to how much vision a patient retains. Now a team of Australian-Brazilian researchers led by RMIT University have developed ...
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23. Optical Coherence Tomography and Retinal Thickness Analyzer Features of Spontaneous Resolution of Vitreomacular Traction Syndrome: A Case Report
  
  Explore SAGE Journals Jan 8 2019 Ophthalmology
  
  Purpose To report optical coherence tomography (OCT) and retinal thickness analyzer (RIA) findings in a case of spontaneous resolution of vitreomacular traction syndrome. METHODS Qualitative and quantitative analysis of the macular region was performed with OCT and RTA. Results In the left eye of a 34-year-old woman with blurred vision, OCT and RTA examination showed a discrete linear signal anterior to the retina with attachment at the macula and secondary cystoid macular changes. OCT and RTA examination showed an increase in macular thickness (350 μm). Six months later the patient showed a spontaneous complete recovery of visual acuity. Vitreomacular traction ...
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24. Using Deep Learning in Automated Detection of Graft Detachment in Descemet Membrane Endothelial Keratoplasty: A Pilot Study
  
  Explore LWW Online Jan 8 2019 Ophthalmology
  
  Purpose: To evaluate a deep learning –based method to automatically detect graft detachment (GD) after Descemet membrane endothelial keratoplasty (DMEK) in anterior segment optical coherence tomography (AS-OCT). Methods: In this study, a total of 1172 AS-OCT images (609: attached graft; 563: detached graft) were used to train and test a deep convolutional neural network to automatically detect GD after DMEK surgery in AS-OCT images. GD was defined as a not completely attached graft. After training with 1072 of these images (559: attached graft; 513: detached graft), the created classifier was tested with the remaining 100 AS-OCT scans (50: attached graft ...
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