1. Articles in category: Ophthalmology

    1-24 of 13163 1 2 3 4 ... 547 548 549 »
    1. Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology

      Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology

      Purpose To report a carefully studied case of high voltage electrical injury of the retina and optic nerve with anatomically reversible retinoschisis. Methods Observational case report. Results A 22 year old power company worker was electrocuted with 12,000 V, with his left forehead being the exit point of the current. After regaining consciousness he reported decreased vision with both eyes. He was extensively tested with optical coherence tomography (OCT) and angiography (OCT-A), fundus photography, fluorescein angiography (FA), multifocal electroretinography (mfERG), full field electroretinography (ffERG), visual evoked potentials (VEP), and Goldmann-type Octopus automated perimetry in addition to careful clinical examinations ...

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    2. Fundus fluorescein angiography and optical coherence tomography findings in ocular and non-ocular Behҫet’s disease

      Fundus fluorescein angiography and optical coherence tomography findings in ocular and non-ocular Behҫet’s disease

      Aim of the work This study aimed at early detection of fundus fluorescein angiography (FFA) findings and optical coherence tomography (OCT) changes denoting active posterior uveitis in Behçet’s Disease (BD) patients before they are clinically evident. Patients and methods This study included 50 BD patients subgrouped according to ocular involvement into ocular and non-ocular Behçet patients. All patients underwent thorough ophthalmological examination. Fundus examination was done to detect signs of intermediate and/or posterior uveitis. OCT conventional and enhanced depth techniques were used for assessment of the macular area and choroidal thickness respectively. FFA was done for ...

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    3. Deep learning architectures analysis for age-related macular degeneration segmentation on optical coherence tomography scans

      Deep learning architectures analysis for age-related macular degeneration segmentation on optical coherence tomography scans

      Background and Objectives: Aged people usually are more to be diagnosed with retinal diseases in developed countries. Retinal capillaries leakage into the retina swells and causes an acute vision loss, which is called age-related macular degeneration (AMD). The disease can not be adequately diagnosed solely using fundus images as depth information is not available. The variations in retina volume assist in monitoring ophthalmological abnormalities. Therefore, high-fidelity AMD segmentation in optical coherence tomography (OCT) imaging modality has raised the attention of researchers as well as those of the medical doctors. Many methods across the years encompassing machine learning approaches and convolutional ...

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    4. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and their associated cardiovascular disease. Homology between the eye and the kidney suggests that noninvasive imaging of the retinal vessels can detect these microvascular alterations to improve targeting of at-risk patients ...

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    5. Optical Coherence Tomography Findings in Tamoxifen Retinopathy

      Optical Coherence Tomography Findings in Tamoxifen Retinopathy

      Purpose To describe optical coherence tomography (OCT) findings in two cases of typical tamoxifen retinopathy. Design Observational cases report. Methods Two patients with tamoxifen retinopathy were imaged with fluorescein angiography and OCT 3. Results Fluorescein angiography showed foveolar hyperfluorescence. OCT revealed a foveolar cystoid space with focal disruption of the photoreceptor line. There was no evidence of macular edema or thickening. Conclusions In both cases, OCT findings are not consistent with previous descriptions of tamoxifen retinopathy, based on fundus examination and fluorescein angiography, which include a description of macular edema. This new imaging suggests that tamoxifen maculopathy may include a ...

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    6. CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To assess the visualization of choroidal granulomas with swept-source optical coherence tomography angiography (OCTA). Methods: Consecutive patients with granulomatous choroiditis due to tuberculosis, sarcoidosis, or Vogt–Koyanagi–Harada disease underwent baseline OCTA images using a 12 × 12-mm field of view, and the choroidal slabs were analyzed by two independent examiners who counted the oval areas of flow void. Simultaneously, indocyanine green angiography (ICGA) and enhanced-depth imaging OCT were performed to mark visible choroidal changes corresponding to granulomatous lesions. The lesion areas on OCTA and ICGA were assessed using the in-built caliper tool. Results: Three hundred and one round-shaped areas ...

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    7. Visibility of microvessels in Optical Coherence Tomography Angiography depends on angular orientation

      Visibility of microvessels in Optical Coherence Tomography Angiography depends on angular orientation

      OCT Angiography (OCTA) is a widespread tool for depth‐resolved imaging of chorioretinal vasculature with single microvessel resolution. To improve the clinical interpretation of OCTA, the conditions affecting visualization of microvessels must be defined. Here we inject a scattering plasma tracer (Intralipid) during OCTA imaging of the anesthetized rat eye. In the retina, we find that interlaminar (vertical) vessels that connect laminae have one‐fourth to one‐third the OCTA red blood cell to tracer (RBC‐to‐tracer) signal ratio of intralaminar (horizontal) vessels. This finding suggests that the OCTA signal from microvessels depends on angular orientation, making vertically‐oriented ...

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    8. Cilioretinal arteries and macular vasculature in highly myopic eyes: an OCT–angiography-based study

      Cilioretinal arteries and macular vasculature in highly myopic eyes: an OCT–angiography-based study

      Purpose To determine the association between the presence of cilioretinal arteries and the macular vasculature in highly myopic eyes using optical coherence tomography angiography (OCTA). Design Retrospective, observational case series. Participants 481 highly myopic eyes of 481 patients. Methods Fundus photographs were reviewed to determine the presence of a cilioretinal artery and its distribution, based on whether its path or visible branches reached the region within 500 μm of the foveal center. The macular vasculature was analyzed in OCTA images, including the vessel density (VD), fractal dimension (FD), and foveal avascular zone (FAZ). The associations between the presence of a ...

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    9. Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration

      Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration

      Purpose : To describe and quantify Bruch's membrane (BM) and retinal pigment epithelium (RPE) separation using spectral-domain (SD) optical coherence tomography (OCT) in patients affected by inherited macular degenerations associated with BM thickening. Methods : Patients with molecularly confirmed Sorsby fundus dystrophy (SFD), dominant drusen (DD), and late-onset retinal degeneration (L-ORD) were included in this retrospective study. Each disease was classed as early stage if subjects were asymptomatic, intermediate stage if they had nyctalopia alone, and late stage if they described loss of central vision. The main outcome was measurement of BM-RPE separation on SD-OCT. The BM-RPE separation measurements were compared ...

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    10. Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope

      Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope

      Background/ims To compare the retinal vessel diameter measurements obtained from the swept-source optical coherence tomography angiography (OCTA; Plex Elite 9000, Carl Zeiss Meditec, USA) and adaptive optics ophthalmoscope (AOO; RTX1, Imagine Eyes, France). Methods Fifteen healthy subjects, 67% women, mean age (SD) 30.87 (6.19) years, were imaged using OCTA and AOO by a single experienced operator on the same day. Each eye was scanned using two OCTA protocols (3×3 mm 2 and 9×9 mm 2 ) and two to five AOO scans (1.2×1.2 mm 2 ). The OCTA and AOO scans were scaled to ...

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    11. Foveal crack sign: an optical coherence tomography sign preceding macular hole after vitrectomy for rhegmatogenous retinal detachment

      Foveal crack sign: an optical coherence tomography sign preceding macular hole after vitrectomy for rhegmatogenous retinal detachment

      Purpose To describe an optical coherence tomography (OCT) sign preceding macular hole (MH) formation after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Design Retrospective observational case series. Methods Patients who underwent PPV for RRD at Osaka Rosai Hospital between January 2014 and December 2017 were analyzed. First, the medical records of the patients who had secondary MH after RRD repair were examined, and their sequential changes of the OCT images until MH formation were evaluated. Second, the OCT findings and the medical records of all patients who underwent PPV for RRD were evaluated based on the findings of ...

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    12. Subclinical retinal microvascular alterations assessed by optical coherence tomography angiography in children with systemic hypertension

      Subclinical retinal microvascular alterations assessed by optical coherence tomography angiography in children with systemic hypertension

      Purpose To compare the foveal avascular zone (FAZ) macular and peripapillary vessel density between children with high blood pressure and healthy subjects. Methods A total of 40 eyes of 20 children with hypertension and 40 eyes of 20 age- and sex-matched healthy controls were included. Capillary vessel density (CVD) in superficial (SCP) and deep (DCP) retinal capillary plexus, peripapillary region, and FAZ were analyzed by optical coherence tomography angiography. Results The mean ages were 15.2 ± 1.5 years (range, 10-18) in patients with hypertension and 14.4 ± 2.8 years (range, 10-18) in healthy controls ( P = 0.742). The ...

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    13. Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice

      Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice

      Retinal disease and loss of vision can result from any disruption of the complex pathways controlling retinal development and homeostasis. Forward genetics provides an excellent tool to find, in an unbiased manner, genes that are essential to these processes. Using N -ethyl- N -nitrosourea mutagenesis in mice in combination with a screening protocol using optical coherence tomography (OCT) and automated meiotic mapping, we identified 11 mutations presumably causative of retinal phenotypes in genes previously known to be essential for retinal integrity. In addition, we found multiple statistically significant gene-phenotype associations that have not been reported previously and decided to target ...

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    14. Optical coherence tomography characteristics of taxane-induced macular edema and other multimodal imaging findings

      Optical coherence tomography characteristics of taxane-induced macular edema and other multimodal imaging findings

      Purpose To identify common optical coherence tomography (OCT) characteristics of taxane-related CME (T-CME) to differentiate it from CME associated with other causes (O-CME) and to present multimodal imaging findings of T-CME. Methods To differentiate T-CME from O-CME, pooled SD-OCT images from 14 previous publications and images obtained from our multicenter case series of 3 patients with multimodal imaging of T-CME were compared with 16 consecutive cases of O-CME. Images were graded by 2 masked retinal specialists based on the presence of pre-specified OCT characteristics such as CME centered around fovea, outer retinal cysts more prominent compared with inner retinal cysts ...

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    15. Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration

      Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration

      Importance The clinical implications of different morphologies of choroidal neovascularization (CNV), as evaluated by optical coherence tomography angiography (OCTA) in neovascular age‐related macular degeneration (nAMD), are lacking. Background To describe the morphology of CNV in nAMD using OCTA, and to compare the visual prognosis and other structural OCT biomarkers between different morphologic patterns. Design Retrospective cohort study. Participants 140 eyes with nAMD treated with anti‐vascular endothelial growth factor (VEGF). Methods Patients were examined using OCTA prior to and at 3, 6, and 12 months after receiving anti‐VEGF therapy. Main Outcome Measures Best‐corrected visual acuity (BCVA) and ...

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    16. The Use of Optical Coherence Tomography Angiography in the Diagnosis of Inflammatory Type 1 Choroidal Neovascularization Secondary to Tuberculosis: A Case Report

      The Use of Optical Coherence Tomography Angiography in the Diagnosis of Inflammatory Type 1 Choroidal Neovascularization Secondary to Tuberculosis: A Case Report

      Purpose : To report a case of choroidal neovascularization (CNV), which was not obvious with dye angiography but was detected with optical coherence tomography angiography (OCTA). Methods : A 50-year-old female presented with decreased vision in her right eye. Funduscopic examination revealed a swollen hyperemic disc, peripapillary exudation, and choroidal infiltration. Results : Optical coherence tomography revealed intraretinal cysts, subretinal fluid in the macular region, and subretinal hyperreflective material in the papillomacular area. Fluorescein angiography revealed early hypofluorescence in the areas of choroidal infiltrations, and indocyanine green angiography (ICGA) also showed hypocyanescence corresponding to these infiltrations and revealed a faint hypocyanescence in the ...

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    17. Improving the Detection of Glaucoma and Its Progression: A Topographical Approach

      Improving the Detection of Glaucoma and Its Progression: A Topographical Approach

      Glaucoma is typically defined as a progressive optic neuropathy characterized by a specific (arcuate) pattern of visual field (VF) and anatomical changes. Therefore, we should be comparing arcuate patterns of damage seen on VFs with those seen on optical coherence tomography ( OCT ) maps. Instead, clinicians often use summary metrics such as VF pattern standard deviation (PSD), OCT retinal nerve fiber (RNF) global thickness, etc. There are two major impediments to topographically comparing patterns of damage on VF and OCT maps. First, until recently, it was not easy to make these comparisons with commercial reports. While recent reports do make it ...

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    18. Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis

      Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis

      Purpose : To investigate the spatial characteristics and patterns of structural progression using the combined retinal nerve fiber layer (RNFL) and ganglion cell–inner plexiform layer event-based progression analysis feature provided by the Guided Progression Analysis (GPA) software of spectral-domain optical coherence tomography. Methods : In this retrospective observational study, we evaluated 89 patients with open-angle glaucoma showing clinically confirmed structural progression within a minimum follow-up period of 3 years. For each eye, the RNFL and ganglion cell–inner plexiform layer GPA data were extracted from serial spectral-domain optical coherence tomography (HD-OCT 4000, Carl Zeiss Meditec, Inc., Dublin, CA) data from 2012 ...

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    19. Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Reversal of Edematous Punctal Occlusion

      Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Reversal of Edematous Punctal Occlusion

      Aim: To evaluate the role of anterior segment–optical coherence tomography (AS-OCT) in the diagnosis of punctal stenosis and to compare punctal parameters before and after medical treatment. Patients and Methods: The study was conducted on 40 eyes of 24 patients who had acquired inflammatory punctal stenosis and had persistent epiphora (persistent epiphora group – PEG), and 20 eyes of 10 subjects with normal punctal openings as a control group (control group – CG). We measured the outer punctal diameter (OPD), recorded the visibility of the internal punctum and punctal depth (PD) using AS-OCT, before and 1 month after treatment with preservative ...

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    20. Optical coherence tomography angiography markers associated with treatment response in neovascular age-related macular degeneration

      Optical coherence tomography angiography markers associated with treatment response in neovascular age-related macular degeneration

      Purpose: To investigate whether qualitative and quantitative features of choroidal neovascular membranes are associated with anti-vascular endothelial growth factor treatment response in patients with neovascular age-related macular degeneration. Methods: A total of 41 eyes were included in this cross-sectional observational study and divided into “good responders” and “poor responders” based on the long-term functional changes, frequency of recurrent choroidal neovascular activity, and injection need. Enface optical coherence tomography angiography images were obtained and qualitative features of choroidal neovascular membranes were described based on vessel network density. Then, quantitative measurements including vessel area, vessel length, junction density, and lacunarity were calculated ...

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    21. Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

      Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

      Background Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS OCT findings in cases of PUK. Methods Retrospective observational case series of six eyes presenting with a PUK and proven systemic vasculitis. Clinical course, slit lamp photographs, and AS OCT findings were the main outcomes. Results The AS OCT findings were found to correlate with the ocular disease’s level of activity. In the acute stage, an ...

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      Mentions: UCLA
    22. Morphologic Features of Buried Optic Disc Drusen on En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

      Morphologic Features of Buried Optic Disc Drusen on En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

      We read with interest the work of Kim and associates 1 and their use of optical coherence tomography angiography (OCTA) to define peripapillary vascular structures in eyes with presumed optic disc drusen (ODD) and optic disc edema (ODE) in an effort to understand pathogenesis and local architecture. We leave the question of their definition of ODD to a separate letter for which we are co-authors and focus here on the reported vascular abnormalities in various etiologies of ODE including papilledema, optic neuritis, and nonarteritic anterior ischemic optic neuropathy (NAION). They report a significant qualitative decrease in retinal peripapillary capillary (RPC ...

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    23. Optical coherence tomography neurodegenerative findings in patients with bipolar disorder

      Optical coherence tomography neurodegenerative findings in patients with bipolar disorder

      Introduction Neuroimaging studies of patients with bipolar disorder (BD) have recently revealed neurodegenerative changes in the central nervous system. Optical coherence tomography (OCT) imaging of the retina, as an extension of brain, may be a biomarker in understanding the neurobiology of the disease. To assess OCT as a tool to detect neurodegeneration in BD we compared the retinal changes between patients with BD and healthy individuals. Methods We performed complete ophthalmological examinations and took OCT images for 70 eyes of 70 patients with BD, and for age and sex‐matched individual controls. We compared retinal nerve fiber layers (RNFLs) and ...

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