1. Articles in category: Ophthalmology

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    1. Haag-Streit UK appointed sole distributor of the Optovue, Inc. portfolio in the UK

      Haag-Streit UK appointed sole distributor of the Optovue, Inc. portfolio in the UK

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce that it will be appointed sole distributor of the Optovue, Inc. product portfolio in the UK from 4th February 2015. Optovue, Inc, has a reputation for pushing the frontiers of innovation and ophthalmic medical diagnostic imaging with its Optical Coherence Tomography (OCT) product portfolio, which includes the: Angiovue OCT Angiography system, iVue, iFusion, iScan and XR Avanti OCT products. HS-UK will be taking over the UK distribution from Watford-based Grafton Optical, Optovue, Inc distributors since January 2007. Bill Shields, Vice President International ...

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    2. Utility Of Optical Coherence Tomography In The Evaluation Of Patients With Ethambutol-Induced Optic Neuropathy

      Utility Of Optical Coherence Tomography In The Evaluation Of Patients With Ethambutol-Induced Optic Neuropathy

      In this study, optical coherence tomography (OCT) was used to evaluate retinal thickness in two patients with optic neuropathy who had recently discontinued ethambutol. OCT was used to measure retinal nerve fiber layer (RNFL) thickness and to map the RNFL, ganglion cell layer (GCL), and inner plexiform layer (IPL). Decreased RNFL thickness was observed in one case. However, the combined RNFL, GCL, and IPL map showed significant decreases in retinal thickness in both cases, suggesting that ethambutol likely affects the GCL as well as the RNFL. I propose that the GCL thickness should be considered in addition to the RNFL ...

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      Mentions: Nidek Nidek RS-3000
    3. OCT measurements of optic nerve head changes in idiopathic intracranial hypertension

      OCT measurements of optic nerve head changes in idiopathic intracranial hypertension

      Objective Severity of papilledema and vision loss constitute a basis for therapeutic intervention in idiopathic intracranial hypertension (IIH), but both are often subjective and insensitive in guiding clinical management. The aim of this study was to identify reliable and sensitive measurements of optic nerve head (ONH) and macula, to provide objective guidance for prognostic evaluation and treatment in IIH. We analyzed potential of spectral domain optical coherence tomography (SD-OCT), to measure neuro-retinal rim thickness and area, optic cup-to-disc ratio (C/D) and cup volume of ONH which have not previously been reported in IIH. In parallel, thickness of peripapillary retinal ...

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    4. Longitudinal modifications of the Ozurdex intravitreal implant as imaged by SD-OCT

      Longitudinal modifications of the Ozurdex intravitreal implant as imaged by SD-OCT

      To describe in vivo longitudinal modifications of the Ozurdex intravitreal implant using spectral-domain optical coherence tomography (SD-OCT) over a 6-month period in an eye treated for retinal vein occlusion (RVO). Case report. An 82-year-old woman with severe macular edema secondary to branch RVO received an Ozurdex intravitreal implant in the left eye. At day 1, SD-OCT showed that the implant was completely filled with highly reflective dexamethasone. At day 30, complete resolution of macular edema on SD-OCT was noted. At day 60, macular edema started to relapse; SD-OCT scans over the implant showed highly reflective borders that appeared irregular and ...

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    5. Fluorescein angiography and optical coherence tomography in myopic choroidal neovascularization

      Fluorescein angiography and optical coherence tomography in myopic choroidal neovascularization

      Purpose To assess intra / inter-observer agreement, and diagnostic capabilities of a color fundus photograph, fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) in making a diagnosis of myopic choroidal neovascularization (CNV). Patients and methods Two masked observers evaluated FFA and SD-OCT images to identify the presence of myopic CNV in 80 high-myopic eyes of 57 patients. A third masked observer identified CNV on a color fundus photo. Presence of myopic CNV on a fundus photo was defined as presence of subretinal hemorrhage, thickening of the retina and / or visible membrane at the macula. Presence of myopic CNV ...

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    6. Fast segmentation of anterior segment optical coherence tomography images using graph cut

      Fast segmentation of anterior segment optical coherence tomography images using graph cut

      BackgroundOptical coherence tomography (OCT) is a non-invasive imaging system that can be used to obtain images of the anterior segment. Automatic segmentation of these images will enable them to be used to construct patient specific biomechanical models of the human eye. These models could be used to help with treatment planning and diagnosis of patients.MethodsA novel graph cut technique using regional and shape terms was developed. It was evaluated by segmenting 39 OCT images of the anterior segment. The results of this were compared with manual segmentation and a previously reported level set segmentation technique. Three different comparison techniques ...

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      Mentions: Yalin Zheng
    7. Evaluation of a Method for Estimating Retinal Ganglion Cell Counts Using Visual Fields and Optical Coherence Tomography

      Evaluation of a Method for Estimating Retinal Ganglion Cell Counts Using Visual Fields and Optical Coherence Tomography

      Purpose : To evaluate the accuracy and generalizability of a published model that derives estimates of retinal ganglion cell (RGC) counts and relates structural and functional changes due to glaucoma. Methods : Both the Harwerth et al. non−linear model (H−NLM) and the Hood and Kardon linear model (HK−LM) were applied to an independent dataset of frequency−domain optical coherence tomography and visual fields, consisting of 48 eyes of 48 healthy controls, 100 eyes of 77 glaucoma patients and suspects, and 18 eyes of 14 non−arteritic anterior ischemic optic neuropathy (ION) patients with severe vision loss. Using the coefficient ...

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    8. Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)

      Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)

      Mwanza et al 1 evaluated the performance of ganglion cell inner-plexiform layer (GCIPL) parameters used alone or in combination with retinal nerve fiber layer (RNFL) and optic nerve head parameters for the early diagnosis of glaucoma. They also provide positive (PLR) and negative (NLR) likelihood ratios (LR) that are valuable for clinical use.

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    9. Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration

      Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration

      In the article by Castillo et al 1 (see page 399 ), the authors provide a thoughtful review of “the accuracy of optical coherence tomography (OCT) [compared] with alternative tests for monitoring neovascular age-related macular degeneration (nAMD) and detecting disease activity among eyes previously treated for this condition.” The topic is important. The article focuses mainly on whether OCT can replace fluorescein angiography (FA) because OCT is safer, more convenient, and less costly. Their conclusion is that OCT cannot replace FA: “There is a substantial disagreement between OCT and FA findings in detecting active disease in patients with nAMD who are ...

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    10. Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography

      Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography

      Purpose The aim of this study was to assess the effect of a single drop of hyaluronic acid on tear film thickness (TFT) in healthy subjects. Methods Sixteen healthy subjects (eight male/eight female) aged between 20 and 36 years were included in this randomized, double-masked placebo-controlled study. One eye received a single dose of hyaluronic acid (Olixia pure ® ; Croma Pharma, Korneuburg, Austria) eye drops, and the fellow eye received physiologic saline solution as placebo control. The study eye was chosen randomly. TFT as measured with a custom-built Fourier-domain optical coherence tomography (FD-OCT) system was the main outcome variable and ...

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    11. OPTICAL COHERENCE TOMOGRAPHY-BASED POSITIONING REGIMEN FOR MACULAR HOLE SURGERY

      OPTICAL COHERENCE TOMOGRAPHY-BASED POSITIONING REGIMEN FOR MACULAR HOLE SURGERY

      Purpose: To evaluate an optical coherence tomography (OCT)-based positioning regimen for patients undergoing macular hole surgery. Method: We reviewed the medical records of all patients in our practice who underwent macular hole repair, instituting a modified OCT-based positioning regimen from November 1, 2011 through July 31, 2013. The regimen consisted of prone positioning at the conclusion of surgery with daily OCT imaging until the hole was confirmed closed at which point positioning was halted. Clinical data that were collected and recorded included visual acuities, stage of hole, size of hole, chronicity, preoperative and postoperative OCT imaging, and length of ...

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    12. Comparison between the measurements of different parameters obtained from optic nerve head analysis by using Heidelberg retinal tomography (HRT3) and Optical coherence tomography (Stratus OCT)

      Comparison between the measurements of different parameters obtained from optic nerve head analysis by using Heidelberg retinal tomography (HRT3) and Optical coherence tomography (Stratus OCT)

      Purpose: A cross-sectional prospective nonrandomized study was undertaken to find out whether Heidelberg retinal tomography (HRT3) and Optical coherence tomography (Stratus OCT) could be used interchangeably for the measurement of different parameters of optic nerve head in clinical practice. Materials and Methods: Measurements of disc area, cup area, rim area and cup-disc area ratio were obtained with the HRT3 and Stratus OCT printouts in 18 patients aged 20 to 70 years. True agreements between methods in measuring disc area, cup area, rim area and cup-disc area ratio were assessed using Bland-Altman statistical analysis. Eighteen patients with a mean age of ...

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    13. Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

      Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

      Background : The present cross-sectional study has the purpose to investigate the impact of aromatase inhibitors (AIs) on retinal nerve fiber layer (RNFL) thickness, optic nerve and macular function in patients using AIs for breast cancer treatment. Methods : Participants in our study were 41 hormone-receptor-positive earlystage breast cancer patients who were treated with AIs in the adjuvant setting. Moreover, 40 age- and gender-matched control subjects, having neither ocular nor systemic disorders, were included in this study. All participants underwent a complete ophthalmological examination, including best corrected visual acuity (BCVA) assessment, RNFL thickness and central foveal thickness (CFT) measurement, visual evoked potentials ...

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    14. The effect of rebreathing and hyperventilation on retinal and choroidal vessels measured by spectral domain optical coherence tomography Read More: http://informahealthcare.com/doi/abs/10.3109/15569527.2014.990154

      The effect of rebreathing and hyperventilation on retinal and choroidal vessels measured by spectral domain optical coherence tomography   Read More: http://informahealthcare.com/doi/abs/10.3109/15569527.2014.990154

      Objective : The purpose of this study was to examine the vasoreactivity in retina and choroid of the healthy eyes in response to experimentally altered partial arterial pressure of carbon dioxide (PaCO 2 ) using a non-invasive technique, spectral domain optical coherence tomography (SD-OCT). Materials and methods : The study included non-smoking participants between 18 and 35 years of age, having visual acuity of 20/20 and with no systemic and ocular diseases. At baseline, the participants breathed room air (normocapnia). Hypocapnia was created with the help of hyperventilation; for this, the participants were instructed to draw deep and quick breaths, resulting one ...

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    15. Bausch + Lomb Introduces New Software and Advanced OCT Imaging System for VICTUS® Femtosecond Laser Platform

      Bausch + Lomb Introduces New Software and Advanced OCT Imaging System for VICTUS® Femtosecond Laser Platform

      Valeant Pharmaceuticals International, Inc. (NYSE: VRX and TSX: VRX) today announced that its wholly owned subsidiary, Bausch + Lomb, has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for an advanced Swept Source OCT (Optical Coherence Tomography) imaging system and updated software for its VICTUS ® Femtosecond Laser Platform that will provide surgeons with a new, redesigned interface. The intuitive interface is designed to allow faster, simpler customized treatment planning to help surgeons improve efficiency and patient-flow during surgical procedures. "With the availability of the advanced OCT imaging and software enhancements, surgeons can monitor treatments in real-time ...

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    16. Optical Coherence Tomography: Detecting Disease Early Through Retinal Imaging

      Optical Coherence Tomography: Detecting Disease Early Through Retinal Imaging

      Early diagnosis of individuals with chronic disease is a global health goal because the sooner a physician can detect a disease in a patient, the better the prognosis. In the U.S. alone, more than 6 million people have diabetes without knowing it, according to a 2009 study. That study estimated the cost of undiagnosed type-2 diabetes in medical services and lost productivity to be $18 billion a year. Eye researchers have observed that many chronic diseases, such as diabetes, hypertension, and cardiovascular and cerebrovascular conditions, leave telltale clues of their presence in the retina. By detecting these clues using ...

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    17. Monitoring Cerebral Hemodynamics Following Optogenetic Stimulation via Optical Coherence Tomography

      Monitoring Cerebral Hemodynamics Following Optogenetic Stimulation via Optical Coherence Tomography

      In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.

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    18. Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

      Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

      Ophthalmologists typically acquire different image modalities to diagnose eye pathologies. They comprise, e.g., Fundus photography, optical coherence tomography, computed tomography, and magnetic resonance imaging (MRI). Yet, these images are often complementary and do express the same pathologies in a different way. Some pathologies are only visible in a particular modality. Thus, it is beneficial for the ophthalmologist to have these modalities fused into a single patient-specific model. The goal of this paper is a fusion of Fundus photography with segmented MRI volumes. This adds information to MRI that was not visible before like vessels and the macula. This paper ...

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    19. Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

      Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

      Purpose: We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). Methods: Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively. Results: The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage. Conclusions: The ...

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    20. New neuroretinal rim analysis with spectral domain optical coherence tomography, Spectralis (Heidelberg Engineering, Germany). Preliminary study

      New neuroretinal rim analysis with spectral domain optical coherence tomography, Spectralis (Heidelberg Engineering, Germany). Preliminary study

      Introduction Clinical determination of the outer limits of the optic disk (OD) doesn’t always correspond to the true anatomic limits of the optic nerve head (ONH) defined by the Bruch's membrane opening (BMO). A new index analyzing the OD with optical coherence tomography (OCT), “minimal rim width” (BMO-MRW), evaluates the smallest thickness of the neuroretinal rim between the BMO and the internal limiting membrane. The purpose of this study was to evaluate new software for automatic measurement of the BMO-MRW. Materials and methods This study investigated 95 eyes: 40 control eyes and 55 eyes followed and treated for ...

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    21. Pulsatile motion of trabecular meshwork in a patient with iris cyst by phase-sensitive optical coherence tomography: a case report

      Pulsatile motion of trabecular meshwork in a patient with iris cyst by phase-sensitive optical coherence tomography: a case report

      45-year-old man was diagnosed with a 3 mm × 3 mm iris cyst located at 9 o’clock behind iris and protruding into temporal angle by slit lamp examination, gonioscopy, and ultrasound biomicroscopy (UBM). Phase-sensitive optical coherence tomography (PhS-OCT) was applied on this case for the quantitative measurements of trabecular meshwork (TM) motion. The frequency of TM motion was with the same rhythm of the patient’s peripheral pulse. Its amplitude on the closed angle region showed significant smaller than the open angle region. PhS-OCT can be a useful tool for the diagnosis and follow-up in ocular diseases surrounding iridocorneal angle.

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    22. Correlation between Fourier-Domain Optical Coherence Tomography Parameters and HbA1c Level and Diabetes Duration in Early Stage Diabetic Retinopathy

      Correlation between Fourier-Domain Optical Coherence Tomography Parameters and HbA1c Level and Diabetes Duration in Early Stage Diabetic Retinopathy

      We examined a significant correlation between Fourier-domain optical coherence tomography (FD-OCT) parameters and the glycosylated hemoglobin A1c (HbA1c) level and duration of diabetes mellitus (DM) in patients at the early stage of diabetic retinopathy (DR). Thirty eyes of 30 patients with early stage DR that were examined at the Chiba University Hospital were studied. The macular map 5 (MM5), the retinal nerve fiber layer thickness, and the ganglion cell complex thickness were obtained by FD-OCT. The coefficients of correlation between these parameters and the HbA1c level and the DM duration were determined by Spearman rank correlation. The thickness of the ...

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    23. New developments in optical coherence tomography

      New developments in optical coherence tomography

      Purpose of review: Optical coherence tomography (OCT) has become the cornerstone technology for clinical ocular imaging in the past few years. The technology is still rapidly evolving with newly developed applications. This manuscript reviews recent innovative OCT applications for glaucoma diagnosis and management. Recent findings: The improvements made in the technology have resulted in increased scanning speed, axial and transverse resolution, and more effective use of the OCT technology as a component of multimodal imaging tools. At the same time, the parallel evolution in novel algorithms makes it possible to efficiently analyze the increased volume of acquired data. Summary: The ...

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    24. Optical coherence tomography based microangiography for quantitative monitoring of structural and vascular changes in a rat model of acute uveitis in vivo: a preliminary study

      Optical coherence tomography based microangiography for quantitative monitoring of structural and vascular changes in a rat model of acute uveitis in vivo: a preliminary study

      Uveitis models in rodents are important in the investigation of pathogenesis in human uveitis and the development of appropriate therapeutic strategies for treatment. Quantitative monitoring of ocular inflammation in small animal models provides an objective metric to assess uveitis progression and/or therapeutic effects. We present a new application of optical coherence tomography (OCT) and OCT-based microangiography (OMAG) to a rat model of acute anterior uveitis induced by intravitreal injection of a killed mycobacterial extract. OCT/OMAG is used to provide noninvasive three-dimensional imaging of the anterior segment of the eyes prior to injection (baseline) and two days post-injection (peak ...

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