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Articles in category: Ophthalmology
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Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis
Read Full ArticleBackground . The aim of this study was to assess the retinal and choroidal microvasculature features using optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP). Methods . This study was a meta-analysis of relevant published studies that were included after a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. Mean difference (MD) with a 95% confidence interval was used to assess continuous variable outcomes. Heterogeneity was evaluated using the chi-squared test based on the values of and I 2 . Results . Seven studies were included in this meta-analysis. The vessel density values measured in the superficial ...
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The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography
Read Full ArticlePurpose This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. Methods This was a retrospective study where subjects aged 5–18 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. Results A total of 71 normal eyes from 71 subjects were enrolled. For the macula, the mean VD of fovea, parafovea, and perifovea at superficial retina and deep retina were 20 ...
Mentions: Sun Yat-Sen University -
Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography
Read Full ArticlePurpose To evaluate the three-dimensional choroidal vascularity index (CVI) in the eyes with treatment-naïve acute central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (SS OCT). Methods In this prospective cross-sectional study, OCT and OCT angiography covered an area of 12 × 12 mm centered on the fovea. Three-dimensional CVI was defined as the ratio of the choroidal vascular luminal volume to the total choroidal volume. The location of pigment epithelial detachment (PED) and the area with abnormal perfusion at choriocapillary layer were compared with the distribution of the three-dimensional CVI. Results Thirty-two eyes with treatment-naïve acute CSC, 18 ...
Mentions: Chinese Academy of Sciences -
Optical coherence tomography angiography assessment of retinal microvascular changes in diabetic eyes in an urban safety-net hospital
Read Full ArticlePURPOSE To determine whether quantitative optical coherence tomography angiography (OCTA) parameters can be used to distinguish among eyes at various stages of diabetic retinopathy (DR) in an urban safety-net hospital population. DESIGN Prospective cross-sectional study PARTICIPANTS 329 eyes from 329 patients were included in this study; 90 nondiabetic patients, 170 diabetic patients without retinopathy, 57 diabetes with mild to moderate NPDR, and 12 diabetes with severe NPDR to PDR. METHODS Patients underwent OCTA imaging and ultra-widefield fundus photography at Zuckerberg San Francisco General Hospital and Trauma Center between April and October 2018. For participants with diabetes, imaging was classified according ...
Mentions: UCSF -
Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy
Read Full ArticlePurpose : To analyze imaging artifacts and segmentation errors with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in diabetic retinopathy (DR). Methods : We conducted a prospective, observational study at Massachusetts Eye and Ear from December 2018 to March 2019. Proliferative diabetic retinopathy (PDR), nonproliferative diabetic retinopathy (NPDR), diabetic patients with no diabetic retinopathy (DR), and healthy control eyes were included. All patients were imaged with a SS-OCTA and the Montage Angio (15 × 9 mm) was used for analysis. Images were independently evaluated by two graders using the motion artifact score (MAS). All statistical analyses were performed using SPSS 25.0 and ...
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Repeatability of Optical Coherence Tomography Angiography in Uveitic Eyes
Read Full ArticlePurpose : To investigate the intravisit repeatability of optical coherence tomography angiography (OCTA) in a cohort of uveitis patients. Methods : One hundred ten patients were imaged twice per eye, per visit, using the Zeiss Cirrus HD-OCT Model 5000 device. To calculate choriocapillaris flow void area (CC FV) 6 × 6-mm images were used, and 3 × 3-mm images were used to calculate vessel density (VD) and the foveal avascular zone area (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Repeatability was measured using Bland-Altman analyses and intraclass correlation coefficients (ICC) with associated coefficient of variation (CV). Results : The level ...
Mentions: National Institutes of Health -
Comment on ‘Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis
Mentions: University of Bonn -
Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs
Read Full ArticleAbstract Purpose To compare the diagnostic performance of human gradings versus predictions provided by a machine-to-machine (M2M) deep learning (DL) algorithm trained to quantify retinal nerve fiber layer (RNFL) damage on fundus photographs. Design Evaluation of a machine learning algorithm. Methods A M2M DL algorithm trained with RNFL thickness parameters from spectral-domain optical coherence tomography was applied to a subset of 490 fundus photos of 490 eyes of 370 subjects graded by two glaucoma specialists for the probability of glaucomatous optical neuropathy (GON), and estimates of cup-to-disc (C/D) ratios. Spearman correlations with standard automated perimetry (SAP) global indices were ...
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Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa
Read Full ArticlePurpose To investigate the association of retinal biomarkers with the choroidal parameters in retinitis pigmentosa (RP). Methods This prospective study included 69 eyes of 36 patients with RP. Choroidal vascularity index (CVI) was defined as the ratio of luminal area to stromal area after binarization on EDI–OCT images. Choroidal thickness (CT); peripapillary CT, the disruptions of the ellipsoid zone (EZ) and external limiting membrane (ELM); and the existence of disorganization of the retinal inner layers (DRIL) and epiretinal membrane (ERM) in central 1000 μm were noted. Results Having DRIL and the disruption of EZ and ELM was significantly associated ...
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Deep learning-based automated detection of retinal diseases using optical coherence tomography images
Read Full ArticleRetinal disease classification is a significant problem in computer-aided diagnosis (CAD) for medical applications. This paper is focused on a 4-class classification problem to automatically detect choroidal neovascularization (CNV), diabetic macular edema (DME), DRUSEN, and NORMAL in optical coherence tomography (OCT) images. The proposed classification algorithm adopted an ensemble of four classification model instances to identify retinal OCT images, each of which was based on an improved residual neural network (ResNet50). The experiment followed a patient-level 10-fold cross-validation process, on development retinal OCT image dataset. The proposed approach achieved 0.973 (95% confidence interval [CI], 0.971–0.975) classification ...
Mentions: Florida International University -
Evaluation of the effects of selective laser trabeculoplasty on anterior segment parameters by anterior segment optical coherence tomography
Read Full ArticleTo prospectively examine the effects of selective laser trabeculoplasty (SLT) on the anterior chamber angle (ACA) and its related parameters using anterior segment-optic coherence tomography (AS-OCT). Fifty eyes of 50 patients with primary open angle glaucoma (POAG) and ocular hypertension were included in the study. AS-OCT was performed before SLT application, immediately after and at 1 day and 1 month. Intraocular pressure (IOP), central corneal thickness (CCT) and anterior chamber depth (ACD) were also recorded and evaluated. No statistically significant difference was determined in ACA and other AS-OCT parameters (AOD, angle opening distance at 500 and 750 mm; TISA, trabecular-iris ...
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An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification
Read Full ArticleAims: To present an authoritative, universal, easy-to-use morphologic classification of diabetic maculopathy based on spectral domain optical coherence tomography. Methods: The first draft of the project was developed based on previously published classifications and a literature search regarding the spectral domain optical coherence tomography quantitative and qualitative features of diabetic maculopathy. This draft was sent to an international panel of retina experts for a first revision. The panel met at the European School for Advanced Studies in Ophthalmology headquarters in Lugano, Switzerland, and elaborated the final document. Results: Seven tomographic qualitative and quantitative features are taken into account and scored ...
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Microscope-Integrated Optical Coherence Tomography-guided Drainage of Acute Corneal Hydrops in Keratoconus Combined with Suturing and Gas-aided Reattachment of Descemet Membrane”
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Semiautomated optical coherence tomography-guided robotic surgery for porcine lens removal
Read Full ArticlePurpose To evaluate semiautomated surgical lens extraction procedures using the optical coherence tomography (OCT)–integrated Intraocular Robotic Interventional Surgical System. Setting Stein Eye Institute and Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, USA. Design Experimental study. Methods Semiautomated lens extraction was performed on postmortem pig eyes using a robotic platform integrated with an OCT imaging system. Lens extraction was performed using a series of automated steps including robot-to-eye alignment, irrigation/aspiration (I/A) handpiece insertion, anatomic modeling, surgical path planning, and I/A handpiece navigation. Intraoperative surgical supervision and human intervention were enabled by real-time OCT ...
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Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy
Read Full ArticleBackground Progressive myelopathy is the main cause of disability in adrenoleukodystrophy (ALD). Development of therapies is hampered by a lack of quantitative outcome measures. In this study, we investigated whether myelopathy in ALD is associated with retinal neurodegeneration on optical coherence tomography (OCT), which could serve as a surrogate outcome measure. Methods Sixty-two patients (29 men and 33 women) and 70 age-matched and sex-matched controls (33 men and 37 women) were included in this cross-sectional study. We compared retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness between ALD patients and controls ...
Mentions: Frank D. Verbraak -
Trends in Retina Specialist Imaging Utilization from 2012 to 2016 in the United States Medicare Fee-for-Service Population
Read Full ArticlePurpose To characterize temporal trends and regional variance in retinal imaging utilization in the United States Medicare fee-for-service population from 2012–2016. Design Cross-sectional, retrospective database analysis. Methods This study addresses office or operating-room based retinal imaging. Our study population included retina specialists, defined as ophthalmologists performing either intravitreal anti–vascular endothelial growth factor injections or posterior segment laser photocoagulation and no neodymium-doped yttrium aluminum garnet laser capsulotomy. We recorded fundus photography, optical coherence tomography (OCT), intravenous fluorescein angiography (IVFA), indocyanine-green angiography, and ophthalmic ultrasound (B-scan) billed in the Medicare fee-for-service population from 2012–2016. Imaging obtained on any platform ...
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Optical Coherence Tomography Monitoring in a Patient With Retinoblastoma
Read Full ArticleA 17-month-old girl with group B retinoblastoma in her right eye developed recurrence of a parafoveal tumor ( Figure , A) after 6 cycles of intravenous chemotherapy. Despite treatment with indocyanine green–enhanced transpupillary thermotherapy, optical coherence tomography (vertical orientation) demonstrated continued tumor growth toward the foveola. The patient was subsequently treated with 2 cycles of intra-arterial chemotherapy, after which complete tumor regression to a flat scar was documented clinically and by optical coherence tomography (vertical orientation) ( Figure , B). The foveola remained intact. Optical coherence tomography may be a helpful tool in the documentation of retinoblastoma response, particularly in patients with small ...
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Optical Coherence Tomography Angiography in a Patient With Diabetes and Preretinal Neovascularization
Read Full ArticleA 39-year-old patient with type 2 diabetes (diagnosed in 1996) presented for an evaluation of bilateral proliferative diabetic retinopathy that had been treated previously with panretinal photocoagulation. His visual acuity was 20/25 OD. Examination by ophthalmoscopy showed scattered dot-blot intraretinal hemorrhages and an inferotemporal preretinal neovascular frond ( Figure , A). Optical coherence tomography angiography was also performed ( Figure , B).
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Intravitreal Ranibizumab Monotherapy or Combined with Laser for Diabetic Macular Edema (OCT guided study)
Read Full ArticleBackground: Diabetic retinopathy (DR) is the most frequent ocular complication of diabetes mellitus and the leading cause of blindness in the working age population in developing countries. Objective: The aim of this study was to compare central macular thickness using optical coherence tomography (OCT) between Ranibizumab 0.5 mg monotherapy over Ranibizumab 0.5 mg combined with laser based on mean average change in best-corrected visual acuity (BCVA) over 6 months in diabetic macular edema (DME). Patients and methods: The study was carried out on forty eyes of patients aged 30-75 years old, with type 1 or 2 diabetes mellitus ...
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Clinical validation of the RTVue optical coherence tomography angiography image quality indicators
Read Full ArticleImportance All automated image quality indicators for en face optical coherence tomography angiography (OCTA) images require gold standard validation for determining optimal thresholds. Background A manual grading system (gold standard) for OCTA images was validated and compared to two automated image quality indicators: signal strength index (SSI) and scan quality index (SQI) generated by different software versions of the Optovue OCTA device. Design Retrospective cross‐sectional study. Participants 52 eyes of 52 healthy individual and 77 eyes of 51 patients with retinal vascular diseases. Methods 129 OCTA images of the superficial vascular plexus were graded manually by 3 independent examiners ...
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Intraoperative OCT-Assisted Retinal Detachment Repair in the DISCOVER Study: Impact and Outcomes
Read Full ArticlePurpose The purpose of this study is to evaluate intraoperative OCT (iOCT) utility and outcomes during retinal detachment (RD) repair. Design The DISCOVER intraoperative OCT study is a prospective IRB-approved study. Subjects Subjects in the DISCOVER study undergoing surgical repair for RD. Methods This was a post-hoc analysis of eyes in the DISCOVER study undergoing surgical repair for retinal detachments. Inclusion criteria included iOCT following perfluorocarbon liquid (PFO) placement and at least 6 months follow-up. Exclusion criteria included severe retinal pathology unrelated to RD. Surgeons completed standardized questionnaires after each case evaluating the iOCT instrument’s utility. Functional and surgical ...
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Analysis of Retinal Vascular Density using Optical Coherence Tomography Angiography, to Differentiate Healthy, Glaucoma Suspect and Glaucomatous Eyes (Thesis)
Read Full ArticleOBJECTIVES: To study and compare vascular density in papillary retina using OCT Angiography in normals, Glaucoma suspects (Ocular hypertension), early POAG patients and its correlation with RNFL thickness and field changes. METHODS: All volunteers fulfilling eligibility criteria and willing to participate in the study, were recruited in three arms (Minimum sample size of 16 each) and underwent a full ophthalmic examination and investigations (Central corneal thickness, automated visual field testing (HFA 24-2 SITA, threshold test), optical coherence tomography (OCT) RNFL thickness (3.4 mm diameter circle around disc) and OCT angiography (3x3 mm scan) of optic disc, papillary and peri-papillary ...
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Robot prototype shows promise for microsurgery on eyes and aneurysms
Read Full ArticleAdditionally, extensive testing is underway for the incorporation of optical coherence tomography, which is effectively “optical ultrasound” that allows imaging reflections from within tissue.
Mentions: Vanderbilt University
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