Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Misguided Progression Analysis by Optical Coherence Tomography: A Report of Two Cases
  
  Explore Karger Publishers 12 hours, 28 min ago Ophthalmology
  
  Spectral domain optical coherence tomography (SOCT) is an important tool for the diagnosis and management of glaucoma. In an effort to help automate the detection of progressive structural glaucomatous optic nerve damage, Carl Zeiss Meditec has developed Guided Progression Analysis (GPA) software in conjunction with the Cirrus SOCT (Carl Zeiss Meditec, Dublin, Calif., USA). Here, we report a case in which the GPA merged information from 2 different patients, and another case in which data from alternate eyes was compared, making the final analysis invalid.
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  Mentions: Carl Zeiss Meditec FDA Zeiss Cirrus HD-OCT
2. Detection of Fovea-Threatening Diabetic Macular Edema by Optical Coherence Tomography to Maintain Good Vision by Prophylactic Treatment
  
  Explore Karger Publishers 12 hours, 39 min ago Ophthalmology
  
  Background/Aims: To establish a screening and treatment method for fovea-threatening diabetic macular edema (DME) using spectral-domain optical coherence tomography (SD-OCT). In order to maintain good visual acuity (VA), focal/grid laser treatment for screened fovea-threatening DME was evaluated based on macular thickness map images produced by SD-OCT. Methods: In 66 diabetic eyes with no visual deterioration, the sensitivity and the specificity of SD-OCT without the use of mydriatics for the detection of fovea-threatening DME were determined. A definite diagnosis of DME was made under mydriasis, using slitlamp biomicroscopy with a contact lens. Eyes with fovea-threatening DME then underwent prophylactic ...
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  Mentions: Frank G. Holz Robert L. Avery
3. Detection of Retinal Changes in Patients on Long Term Chloroquine/Hydroxy Chloroquine Therapy Using Optical Coherence Tomography
  
  Explore OMICS Group 12 hours, 42 min ago Ophthalmology
  
  Background: The best technique to diagnose chloroquine/ hydroxychloroquine-induced retinopathy changes at the earliest remains ambiguous at present. In this study, we evaluated the time-domain optical coherence tomography (OCT) to identify retinal changes associated with chloroquine and hydroxychloroquine. Methods: One hundred patients with immunological diseases were included in the study. Fifty of them had been on chloroquine and/or hydroxychloroquine therapy for at least five years and the other 50 patients as controls. Detailed ophthalmic examination including Amsler grid , colour vision , automated threshold white perimetry using 10-2 protocol on Humphrey field analyzer, fluorescein angiography when indicated and time domain Optical Coherence ...
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4. The noninvasive predictive approach for choroidal vascular diffuse hyperpermeability in central serous chorioretinopathy: near-infrared reflectance and enhanced depth imaging
  
  Explore ScienceDirect 14 hours, 34 min ago Ophthalmology
  
  Purpose To investigate near-infrared reflectance (NIR) findings in central serous chorioretinopathy (CSCR) and to predict the choroidal vascular diffuse hyperpermeability (CVDHP) by NIR and enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) noninvasively. Methods Retrospective analysis of 52 eyes of 50 CSCR patients with serous macular detachment. All patients received NIR, indocyanine green angiography (ICGA), and EDI SD-OCT. NIR pattern (irregular, defected, masked and enhanced), double layer sign (DLS) in EDI SD-OCT and CVDHP in ICGA were evaluated. In addition, we measured the length of photoreceptor outer segment (LPOS), and subfoveal choroidal thickness (SFCT) by Heidelberg eye explorer software ...
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5. RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
  
  Explore LWW Online 14 hours, 42 min ago Ophthalmology
  
  Purpose: To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Methods: Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 x 40[degrees] on the retina), sensitive to melanin contained in the RPE, based on the polarization state of backscattered light. Conventional intensity-based spectral domain optical coherence tomography and fundus autofluorescence examinations were performed. Retinal pigment epithelium-pigmentation ...
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  Mentions: Christoph K. Hitzenberger Michael Pircher Medical University of Vienna
6. Spectral optical coherence tomography
  
  Explore uspto.gov Jul 22 2014 Ophthalmology , Patents
  
  The invention relates to an apparatus for generating a scannable optical delay for a beam of light and an apparatus for Fourier domain optical coherence tomography having said apparatus for generating a scannable optical delay in its reference arm (15). The light beam is directed to a pivotably driven mirror (10) from where it is reflected to a fixed mirror (12), and from there back retro reflected along the reference arm (5). Lens optics (9) are provided to ensure accurate optical alignment in several pivot positions of the pivotably driven mirror (10).
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  Mentions: Maciej Wojtkowski Optopol Technology Tomasz Bajraszewski
7. Method and system for analyzing optical coherence tomography (OCT) results using color reflectivity discretization analysis
  
  Explore uspto.gov Jul 22 2014 Ophthalmology , Patents
  
  A method of analyzing an OCT image. An OCT image has many differently colored dots. The system detects the number of differently colored dots, quantifies them and performs statistical analysis to determine a likelihood of disease. The different colored dots correspond to different retina cell types and structures.
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8. Image capture apparatus and method
  
  Explore uspto.gov Jul 22 2014 Ophthalmology , Patents
  
  It has been very cumbersome to determine whether or not alignment is required before the fundus image is acquired after the tomographic image is acquired, causing the reduction in diagnostic efficiency. An ophthalmic apparatus is provided to solve this problem, which comprises an irradiation unit that irradiates an eye to be inspected with a first beam for acquiring a tomographic image of the eye and a second beam for acquiring a fundus image of the eye, the second beam having a beam diameter larger than the beam diameter of the first beam; and a determination unit that, based on information ...
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  Mentions: Canon Medical Systems
9. An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model
  
  Explore jmss.mui.ac.ir Jul 21 2014 Ophthalmology
  
  Diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. Thus, the need for precise segmentation of corneal layer boundaries is inevitable. Obviously, manual segmentation is time-consuming and imprecise. In this paper, the Gaussian mixture model (GMM) is used for automatic segmentation of three clinically important corneal boundaries on optical coherence tomography (OCT) images. For this purpose, we apply the GMM method in two consequent steps. In the first step, the GMM is applied on the original image to localize the first and the last boundaries. In the next step, gradient response of a ...
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10. Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome
  
  Explore Home - Springer Jul 21 2014 Ophthalmology
  
  Purpose To report a novel spectral-domain optical coherence tomography (SD-OCT) finding in children affected by tilted disc syndrome (TDS), and to correlate it with early visual field defects. Methods Patients between 5 and 17 years old with TDS were enrolled in this study. The diagnosis of TDS was made by stereoscopic fundus photography, when the upper edge of the optic disc protruded anteriorly relative to its lower edge. All eyes were examined with 12 radial SD-OCT B-scans of 12 mm centered on the optic disc; the fundus area encompassing the optic nerve was additionally scanned using several vertical and horizontal ...
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  Mentions: Tokyo Medical & Dental University Kyoko Ohno-Matsui
11. Optical coherence tomography-guided classification of epiretinal membranes
  
  Explore Home - Springer Jul 21 2014 Ophthalmology
  
  To study and classify epiretinal membranes (ERMs) based on spectral domain optical coherence tomography (SD-OCT) findings. One hundred and twelve patients with ERMs were examined clinically and underwent OCT examination. The anatomical structure of the macula and vitreoretinal interface was studied. ERMs were classified in two categories: A, with posterior vitreous detachment (PVD) (91 cases), and B, with the absence of PVD (21 cases). Category A was divided into two subcategories: A1, without contraction of the ERM (37 cases), and A2, with the presence of membrane contraction (54 cases). A2 was further subdivided into A2.1, with retinal folding (15 ...
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12. Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study
  
  Explore iovs.org Jul 21 2014 Ophthalmology
  
  Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further ...
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13. Inner and outer central retinal findings after surgery for rhegmatogenous retinal detachment using different spectral-domain optical coherence tomography devices
  
  Explore Home - Springer Jul 21 2014 Ophthalmology
  
  Purpose The aim of the study was to analyse macular changes after rhegmatogenous retinal detachment (RRD) repair using spectral-domain optical coherence tomography (SD-OCT). Methods Forty eyes with macula-on and 27 eyes with macula-off RRD underwent scleral buckling or vitrectomy and were postoperatively imaged using 2 SD-OCT devices (Cirrus® HD-OCT, RTVue-100®). Measurement of total and inner macular thickness consisting of ganglion cell layer + inner plexiform layer (GCL-IPL) using Cirrus or retinal nerve fibre layer + ganglion cell layer + inner plexiform layer (RNFL-GCL-IPL) using RTVue was performed. Results of inner macular thickness were compared with image results of 40 healthy controls. Qualitative analysis ...
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  Mentions: Optovue Carl Zeiss Meditec Zeiss Cirrus HD-OCT
14. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma
  
  Explore iovs.org Jul 21 2014 Ophthalmology
  
  Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...
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  Mentions: Optovue RTVue-100 Yonsei University Gong Je Seong
15. An Optical Coherence Tomography-based Analysis of Choroidal Morphologic Features and Choroidal Vascular Diameter in Children and Adults
  
  Explore American Journal of Ophthalmology Jul 21 2014 Ophthalmology
  
  Purpose To analyze choroidal sublayers and vascular diameter in children, and to compare these choroidal features with those of adults. Design Retrospective observational study Methods This study included 96 eyes from 48 healthy children and 54 eyes from 27 healthy adults. The subfoveal choroidal thickness, large choroidal vessel layer thickness, medium choroidal vessel layer-choriocapillaris layer thickness, and large choroidal vessel diameter were estimated. The ratio of thickness of the large choroidal vessel layer to total choroidal thickness was calculated. The association between subfoveal choroidal thickness with large choroidal vessel layer, as well as ratio of thickness of the large choroidal ...
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  Mentions: Sungkyunkwan University Samsung
16. Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study
  
  Explore Nature Publishing Group Jul 21 2014 Ophthalmology
  
  Purpose To compare intraocular lens implantation using a motorized injector vs standard manual injector through a 2.2-mm clear corneal incision. Methods Patients underwent standard phacoemulsification using a 2.2-mm clear corneal incision. Hydrophobic acrylic aspheric intraocular lens (Acrysof SN60WF intraocular lens (IOL)) was inserted using D cartridge with manual monarch injector or autosert motorized injector. IOL safety, final incision size and wound integrity in terms of anterior and posterior wound gape, and descemet’s membrane detachment were compared between the two groups at post-operative day 1 and at 1 month using Anterior Segment Optical Coherence Tomography. Results The study ...
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17. Meta-analysis of Stratus OCT Glaucoma Diagnostic Accuracy
  
  Explore LWW Online Jul 21 2014 Ophthalmology
  
  Purpose: To evaluate the diagnostic accuracy of glaucoma in different stages, different types of glaucoma, and different ethnic groups using Stratus optical coherence tomography (OCT). Methods: We searched MEDLINE to identify available articles on diagnostic accuracy of glaucoma published between January 2004 and December 2011. A PubMed (National Center for Biotechnology Information) search using medical subject headings and keywords was executed using the following terms: "diagnostic accuracy" or "receiver operator characteristic" or "area under curve" or "AUC" and "Stratus OCT" and "glaucoma." The search was subsequently limited to publications in English. The area under a receiver operator characteristic (AUC) curve ...
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  Mentions: Carl Zeiss Meditec Zeiss Stratus OCT
18. Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography
  
  Explore PLoS ONE Jul 21 2014 Ophthalmology
  
  Purpose To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display. Design Observational prospective cross-sectional study. Methods Multiple wide-field three-dimensional SS-OCT scans (500×500A-scans over 12×12 mm 2 ) were obtained using a prototype instrument in 22 eyes of 22 healthy volunteers. A registration ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker
19. Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia
  
  Explore Home | Physiological Reports Jul 21 2014 Ophthalmology
  
  The purpose of this study was to investigate changes in total retinal blood flow (RBF) using Doppler Fourier Domain Optical Coherence Tomography (Doppler FD‐OCT) in response to the manipulation of systemic partial pressure of CO 2 (P ET CO 2 ). Double circular Doppler blood flow scans were captured in nine healthy individuals (mean age ± standard deviation: 27.1 ± 4.1, six males) using the RTVue ™ FD‐OCT (Optovue). P ET CO 2 was manipulated using a custom‐designed computer‐controlled gas blender (RespirAct ™ ) connected to a sequential gas delivery rebreathing circuit. Doppler FD‐OCT measurements were captured at baseline ...
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  Mentions: Optovue David Huang University of Waterloo
20. To Be or not TB?
  
  Explore BJO Online Jul 18 2014 Neurology , Ophthalmology
  
  Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...
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  Mentions: Oregon Health & Science University University of Southern California
21. Diagnosing Macular Degeneration: The Tests that Tell
  
  Explore amdblog.org Jul 17 2014 Ophthalmology
  
  Perhaps you suddenly notice what seems like a constant ‘smudge’ in your central vision. Or maybe straight lines are beginning to seem wavy or distorted. Often, these are the initial symptoms of age-related macular degeneration . Since catching macular degeneration early is imperative in successfully treating the condition, it’s important to acknowledge these symptoms and have a doctor test you for macular degeneration as soon as possible. Through several different tests, physicians can determine if a patient is at risk for AMD, what stage of the disease a patient is at- and how to best stop the disease from progressing ...
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22. Multi-Surface and Multi-Field Co-Segmentation of 3-D Retinal Optical Coherence Tomography
  
  Explore IEEE Xplore Jul 16 2014 Ophthalmology
  
  When segmenting intraretinal layers from multiple optical coherence tomography (OCT) images forming a mosaic or a set of repeated scans, it is attractive to exploit the additional information from the overlapping areas rather than discarding it as redundant, especially in low contrast and noisy images. However, it is currently not clear how to effectively combine the multiple information sources available in the areas of overlap. In this paper, we propose a novel graphtheoretic method for multi-surface multi-field co-segmentation of intraretinal layers, assuring consistent segmentation of the fields across the overlapped areas. After 2D en-face alignment, all the fields are segmented ...
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  Mentions: Michael D. Abràmoff University of Iowa Milan Sonka
23. Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography
  
  Explore LWW Online Jul 16 2014 Neurology , Ophthalmology
  
  A 41-year-old woman with skew deviation had cyclotorsion of both eyes. This resulted in a falsely low probability plot of retinal nerve fiber layer thickness in adjacent clock hours on optical coherence tomography (OCT) due to displacement of the retinal nerve fiber layer peaks. Ocular cyclotorsion may cause misinterpretation of OCT probability plots. OCT retinal nerve fiber layer plots also may be used to objectively quantify the degree of ocular cyclotorsion.
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  Mentions: Randy H. Kardon
24. Optical coherence tomography-guided selective focal laser photocoagulation: a novel laser protocol for diabetic macular edema
  
  Explore Home - Springer Jul 16 2014 Ophthalmology
  
  Background To compare the anatomic and functional results between optical coherence tomography (OCT)-guided selective focal laser photocoagulation (OCT–laser) and conventional modified Early Treatment Diabetic Retinopathy Study (mETDRS) laser treatment for diabetic macular edema (DME). Methods We analyzed treatment outcomes in 47 consecutive eyes treated with OCT–laser compared to 31 matched eyes treated with mETDRS. In the OCT–laser group, we identified ‘significant actively-leaking microaneurysms on OCT’ (SALMO) which are responsible for edema in OCT B-scan images, and thoroughly ablated them with photocoagulation. Best-corrected visual acuity (BCVA) and retinal thickness by OCT were compared at baseline and 12 ...
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  Mentions: Yonsei University Hille W. Van Dijk
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