1. Articles in category: Ophthalmology

    1-24 of 14782 1 2 3 4 ... 614 615 616 »
    1. Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device

      Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device

      Purpose: To describe the feasibility of peripheral OCT imaging in retinal diseases using a novel full-field device. Methods: A total of 134 consecutive eyes were referred and imaged on the Optos Silverstone swept-source OCT (SS-OCT) (Optos PLC; Dunfermline, UK). Scanning laser ophthalmoscope (SLO) images and the associated SS-OCT images were obtained in the posterior pole, mid-periphery or far periphery based on the nature of the referral and on new areas of interest observed in the optomap images at the time of imaging. Results: A total of 134 eyes (96 patients) were enrolled in the study. One hundred and twenty-five eyes ...

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    2. The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective (Book Chapter)

      The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective (Book Chapter)

      Optical coherence tomography (OCT) is a noninvasive ocular imaging technique that has become a standard tool in neuroophthalmic practice. Specifically, OCT captures retinal manifestations of neuroaxonal injury caused by lesions along anterior and posterior regions of the afferent visual pathway, in patients presenting with vision loss. More recently, the advent of OCT angiography (OCTA) has enabled evaluation of the choroidal and retinal microvasculature, thus informing our understanding regarding vascular mechanisms associated with optic nerve and retinal injuries. Much of our longitudinal experience with OCT in the field of neuroophthalmology has been acquired from the study of optic neuritis (ON) caused ...

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    3. 'Y' split of the outer plexiform layer: an optical coherence tomography illusion!

      'Y' split of the outer plexiform layer: an optical coherence tomography illusion!

      We here in report an interesting optical coherence tomography (OCT) observation in two different eyes. First case represents a 26-year-old man, with a history of tobacco chewing for 8 years, presented with sudden onset of scotoma in his right eye for 1 week. The uncorrected visual acuity was 20/40 in right eye (OD) and 20/20 in left eye (OS), respectively. Anterior segment was essentially within normal limits. Right eye fundus examination revealed a dull foveal reflex with neurosensory detachment and subretinal fibrin features suggestive of central serous chorioretinopathy. OCT of OD passing through macula confirmed presence of a ...

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    4. Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography

      Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography

      Optical coherence tomography (OCT) is a three-dimensional (3-D) optical imaging technology that provides noninvasive, micrometer resolution images of structural interiors within biological samples with an approximately 1 ~ 2 mm penetration depth. Over the last decades, advances in OCT have revolutionized biomedical imaging by demonstrating a potential of optical biopsy in preclinical and clinical settings. Recently, functional OCT imaging has shown a promise as angiography to visualize cell-perfused vasculatures in the tissue bed in vivo without requiring any exogenous contrast agents. This new technology termed OCT angiography (OCTA) possesses a unique imaging capability of delineating tissue morphology and blood or lymphatic ...

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    5. Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

      Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

      To analyze the relationships between the fixation location and the visual function of idiopathic macular hole (IMH) patients with macular integrity assessment (MAIA) examination preoperatively and 3 months postoperatively. This was a retrospective case analysis. Forty-three eyes of 43 patients diagnosed with IMH were included in this study. The best corrected visual acuity (BCVA) assessments, optical coherence tomography (OCT) and MAIA examinations were performed before surgery and 1 week, 1 month and 3 months after surgery. The relationships between MAIA parameters and visual acuity were assessed by correlation analysis. Grouping by fixation location with the foveola (2°) as the centre ...

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    6. En face image-based classification of diabetic macular edema using swept source optical coherence tomography

      En face image-based classification of diabetic macular edema using swept source optical coherence tomography

      This retrospective study was performed to classify diabetic macular edema (DME) based on the localization and area of the fluid and to investigate the relationship of the classification with visual acuity (VA). The fluid was visualized using en face optical coherence tomography (OCT) images constructed using swept-source OCT. A total of 128 eyes with DME were included. The retina was segmented into: Segment 1, mainly comprising the inner nuclear layer and outer plexiform layer, including Henle's fiber layer; and Segment 2, mainly comprising the outer nuclear layer. DME was classified as: foveal cystoid space at Segment 1 and no ...

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    7. A Review of Robotic and OCT-Aided Systems for Vitreoretinal Surgery

      A Review of Robotic and OCT-Aided Systems for Vitreoretinal Surgery

      The introduction of the intraocular vitrectomy instrument by Machemer et al. has led to remarkable advancements in vitreoretinal surgery enabling the limitations of human physiologic capabilities to be reached. To overcome the barriers of perception, tremor, and dexterity, robotic technologies have been investigated with current advancements nearing the feasibility for clinical use. There are four categories of robotic systems that have emerged through the research: (1) handheld instruments with intrinsic robotic assistance, (2) hand-on-hand robotic systems, (3) teleoperated robotic systems, and (4) magnetic guidance robots. This review covers the improvements and the remaining needs for safe, cost-effective clinical deployment of ...

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    8. A Swept source optical coherence tomography angiography study: Imaging artifacts and comparison of non-perfusion areas with fluorescein angiography in diabetic macular edema

      A Swept source optical coherence tomography angiography study: Imaging artifacts and comparison of non-perfusion areas with fluorescein angiography in diabetic macular edema

      Purpose Swept Source Optical coherence tomography angiography (SS-OCTA) is a novel technique to visualize perfusion and vascular changes like ischemia in patients with diabetic retinopathy. The aim of this study was to compare non-perfusion areas on conventional fluorescein angiography (FA) with those on SS-OCTA using detailed manual annotation in patients with diabetic macular edema (DME) and to evaluate possible artifacts caused by DME on SS-OCTA. Methods 27 eyes of 21 patients with DME were analyzed in this prospective, cross-sectional study; on all, standard ophthalmological examination, SS-OCTA and FA imaging were performed. Early-phase FA and SS-OCTA images were analyzed for capillary ...

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    9. Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

      Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

      Purpose To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy. Materials and methods A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. SS-OCTA feature was vascularized PEDs on cross-sectional images corresponding to cluster-like structures ...

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    10. Tear evaluation by anterior segment OCT in dry eye disease

      Tear evaluation by anterior segment OCT in dry eye disease

      Objective: Dry Eye Disease (DED) is a multifactorial disorder, centered by loss of tear homeostasis. The diagnosis represents a challenge in the absence of a gold standard, so different questionnaires and techniques are combined. Considering that a low lacrimal secretion and a high rate of evaporation can determine changes in the tear film, the question that arises is if there are differences between the tear film thickness and the tear meniscus values of patients with DED compared to healthy volunteers, and if so, if they can be proposed as an objective diagnosis technique using Optical Coherence Tomography (OCT). Materials and ...

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    11. Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

      Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

      An accurate and automated tissue segmentation algorithm for retinal optical coherence tomography (OCT) images is crucial for the diagnosis of glaucoma. However, due to the presence of the optic disc, the anatomical structure of the peripapillary region of the retina is complicated and is challenging for segmentation. To address this issue, we develop a novel graph convolutional network (GCN)-assisted two-stage framework to simultaneously label the nine retinal layers and the optic disc. Specifically, a multi-scale global reasoning module is inserted between the encoder and decoder of a U-shape neural network to exploit anatomical prior knowledge and perform spatial reasoning ...

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    12. Artios, Novartis Aim to Develop and Discover DDR Targets for Cancer in New Partnership

      Artios, Novartis Aim to Develop and Discover DDR Targets for Cancer in New Partnership

      And in December 2020, Novarits entered into a multi-year collaboration with RetinAI to support projects in ophthalmology and digital health using RetinAI artificial intelligence tools. Under the Master Agreement, the first project launched by the two companies will support an international study of optical coherence tomography image solutions using AI for the assessment of disease activity in patients with neovascular age-related macular degeneration

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      Mentions: RetinAI
    13. Corneal Pachymetry by AS-OCT after Descemet's Membrane Endothelial Keratoplasty

      Corneal Pachymetry by AS-OCT after Descemet's Membrane Endothelial Keratoplasty

      Corneal thickness (pachymetry) maps can be used to monitor restoration of corneal endothelial function, for example after Descemet's membrane endothelial keratoplasty (DMEK). Automated delineation of the corneal interfaces in anterior segment optical coherence tomography (AS-OCT) can be challenging for corneas that are irregularly shaped due to pathology, or as a consequence of surgery, leading to incorrect thickness measurements.

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    14. Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion

      Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion

      Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion ( p = 0 ...

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    15. Optical Coherence Tomography Angiography Artifacts in Glaucoma

      Optical Coherence Tomography Angiography Artifacts in Glaucoma

      Purpose: To determine the prevalence of different types of artifacts seen in optical coherence tomography angiography (OCTA) images of healthy and glaucoma eyes and to evaluate the characteristics associated with the increased likelihood of obtaining poor quality images. Design: Retrospective study. Participants: A total of 649 eyes of 368 healthy, glaucoma suspect, and glaucoma patients. Methods: Angiovue high density (HD) and non-HD optic nerve head and macula OCTA images of participants were evaluated by 4 expert reviewers for the presence of different artifacts including eye movement, defocus, shadow, decentration, segmentation error, blink and Z offset in the superficial vascular layer ...

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      Mentions: UCSD
    16. Optical Coherence Tomography in Uveitis (Book Chapter)

      Optical Coherence Tomography in Uveitis (Book Chapter)

      Uveitis is the comprehensive reference you need for a balanced approach to basic science and clinical application. Robert B. Nussenblatt and Scott M. Whitcup provide a cohesive and integrated discussion of the topic, covering everything from the role of surgery to AIDS to anterior uveitis and more. This new edition even includes full color throughout, 400 photographs and illustrations, and searchable access to the text online at expertconsult.com. Comprehensive yet readable, this resource packs everything you need in patient evaluation and management to achieve optimal results.

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    17. Phase-sensitive optical coherence tomography to measure optical aberrations in anterior segment

      Phase-sensitive optical coherence tomography to measure optical aberrations in anterior segment

      Techniques for measuring optical aberrations of the eye are disclosed. An example method comprises positioning the eye in a measurement location adjacent to a measurement arm of an optical coherence tomography (OCT) interferometer apparatus, so that source light from the measurement arm passes into the anterior segment of the eye and detecting an interference pattern, the interference pattern resulting from a combination of light reflected from the eye and light reflected from a reference arm of the OCT interferometer apparatus. Based on the interference pattern, an optical delay between a reference surface in the anterior segment of the eye and ...

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      Mentions: Alcon
    18. The Role of OCT Angiography in the Assessment of Epiretinal Macular Membrane

      The Role of OCT Angiography in the Assessment of Epiretinal Macular Membrane

      Background: The aim of this observational study is to assess pre- and postoperative retinochoroidal vascular changes in patients undergoing epiretinal macular membrane (ERM) surgery by using optical coherence tomography angiography (OCTA). Materials and methods: 23 eyes affected by ERM and those which underwent phacovitrectomy associated with ERM peeling were enrolled. They were evaluated using structural OCT and OCTA before surgery and at 1, 3, and 6 months postoperatively. Results: We found a statistically significant ( p < 0.05) increase in the superficial capillary plexus vessel density (VD) from baseline to the 6-month follow-up. We observed a large increase in both the ...

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    19. Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia Assessed by Optical Coherence Tomography Angiography

      Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia Assessed by Optical Coherence Tomography Angiography

      The purpose of this study was to evaluate the presence of retinal and microvascular alterations in COVID-19 patients with bilateral pneumonia due to SARS-COV-2 that required hospital admission and compare this with a cohort of age- and sex-matched controls. COVID-19 bilateral pneumonia patients underwent retinal imaging 14 days after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) measurements. Vessel density (VD) and foveal avascular zone (FAZ) area were evaluated in the superficial, deep capillary plexus (SCP, DCP), and choriocapillaris (CC). After exclusion criteria, only one eye per patient was selected, and 50 eyes (25 ...

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    20. Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

      Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

      Mice are widely used as models for many diseases, including eye and neurodegenerative diseases. However, there is a lack of normative data for retinal thickness over time, especially at young ages. In this work, we present a normative thickness database from one to four-months-old, for nine layers/layer-aggregates, including the total retinal thickness, obtained from the segmentation of spectral-domain optical coherence tomography (SD-OCT) data from the C57BL6/129S mouse strain. Based on fifty-seven mice, this normative database provides an opportunity to study the ageing of control mice and characterise disease models' ageing, such as the triple transgenic mouse model of ...

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    21. The Additive Value of Foveal OCT-based Biometry to Fundus Biomicroscopy for Detecting Macular Pathology Prior to Cataract Surgery

      The Additive Value of Foveal OCT-based Biometry to Fundus Biomicroscopy for Detecting Macular Pathology Prior to Cataract Surgery

      Purpose : To assess the additive value of foveal swept-source optical coherence tomography (SS-OCT) based biometry to the preoperative fundus examinations for diagnosing macular abnormalities in patients scheduled for cataract surgery. Design : Diagnostic testing evaluation. Methods : Consecutive patients 50 years of age and older planned for cataract surgery from one institution were retrospectively enrolled. All patients underwent foveal SS-OCT, and macular spectral-domain (SD)-OCT scans before pupil dilation as well as dilated fundus biomicroscopy examination. The effectiveness of fundus biomicroscopy examinations, foveal SS-OCT scans, and the combination of both in identifying macular diseases was analyzed with macular SD-OCT scans as reference ...

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    22. Role of optical coherence tomography angiography in Vogt-Koyanagi-Harada disease

      Role of optical coherence tomography angiography in Vogt-Koyanagi-Harada disease

      Vogt-Koyanagi-Harada disease (VKH) is an autoimmune severe multisystem condition characterized by both ocular and systemic findings that should be promptly recognized and treated. Although invasive imaging modalities, namely fluorescein angiography and indocyanine green angiography, are still the gold standard for the diagnosis and follow-up of the ocular findings in VKH, the role of retinal non-invasive imaging including optical coherence tomography angiography (OCTA) is under investigation and is not mentioned in the current diagnostic criteria of VKH. The aim of this manuscript was to report the clinical course and the multimodal retinal imaging of a VKH case and to discuss the ...

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    23. Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography

      Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography

      Purpose: To investigate the morphological changes of polyps in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors using swept source optical coherence tomography angiography (SS-OCTA). Observations: Following anti-VEGF therapy, polyps were found to evolve into typical type 1 macular neovascularization (MNV) in five eyes. In all of these five eyes, a polypoidal lesion was detected adjacent to a serous or hemorrhagic retinal pigment epithelial detachment (PED). Conclusions and importance: Polypoidal lesions in PCV can evolve into typical type 1 MNV. This morphological evolution suggests that these polyps are clusters of tangled vessels that ...

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    24. Integrating adaptive optics-SLO and OCT for multimodal visualization of the human retinal pigment epithelial mosaic

      Integrating adaptive optics-SLO and OCT for multimodal visualization of the human retinal pigment epithelial mosaic

      In vivo imaging of human retinal pigment epithelial (RPE) cells has been demonstrated through multiple adaptive optics (AO)-based modalities. However, whether consistent and complete information regarding the cellular structure of the RPE mosaic is obtained across these modalities remains uncertain due to limited comparisons performed in the same eye. Here, an imaging platform combining multimodal AO-scanning light ophthalmoscopy (AO-SLO) with AO-optical coherence tomography (AO-OCT) is developed to make a side-by-side comparison of the same RPE cells imaged across four modalities: AO-darkfield, AO-enhanced indocyanine green (AO-ICG), AO-infrared autofluorescence (AO-IRAF), and AO-OCT. Co-registered images were acquired in five subjects, including one ...

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