1. Articles in category: Ophthalmology

    1-24 of 6670 1 2 3 4 ... 276 277 278 »
    1. Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT

      Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT

      Purpose The purpose of this study is to determine the influence of post-surgical corneal edema on the reliability and reproducibility of central corneal thickness (CCT) measurements by a Scheimpflug camera (Pentacam), ultrasound pachymetry (USP), and anterior-segment spectral-domain optical coherence tomography (AS-OCT). Methods Thirty-two patients planned for cataract surgery ( n  = 16) or vitrectomy ( n  =  6) were included in a prospective study. The non-surgery eye was used as control. Two investigators acquired two measurements each, with the Pentacam (Oculus, Germany) and the AS-OCT (Heidelberg Engineering, Germany) in a randomized order, followed by USP (Tomey SP-100, Germany). CCT was evaluated using the apex ...

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    2. Clinical assessment of retinal changes by spectral-domain OCT

      Clinical assessment of retinal changes by spectral-domain OCT

      To evaluate optical coherence tomography changes in patients with retinal thinning at the posterior pole. In this cross-sectional and retrospective study, 648 files were reviewed, and 67 patients were selected. Optical coherence tomography images that showed an area with a retinal thickness reduction at the macular region by using the Asymmetry Analysis Map in Heidelberg Spectralis were selected. The presence of hemisphere asymmetry in the same eye and asymmetry between the paired eyes were calculated and used for the analysis. Retinal thickness was measured in 3 different retinal areas (squares): (1) the area (square) involved by the pathology (IA), (2 ...

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    3. Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle

      Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle

      Clinically, gonioscopy is used to provide en face views of the ocular angle. The angle has been imaged with optical coherence tomography (OCT) through the corneoscleral limbus but is currently unable to image the angle from within the ocular anterior chamber. We developed a novel gonioscopic OCT system that images the angle circumferentially from inside the eye through a custom, radially symmetric, gonioscopic contact lens. We present, to our knowledge, the first 360° circumferential volumes (two normal subjects, two subjects with pathology) of peripheral iris and iridocorneal angle structures obtained via an internal approach not typically available in the clinic.

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    4. Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans

      Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans

      Purpose: To improve our understanding of glaucomatous damage as seen on circumpapillary disc scans obtained with frequency-domain optical coherence tomography (fdOCT), fdOCT scans were compared to images of the peripapillary retinal nerve fiber (RNF) bundles obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO). Methods: The AO-SLO images and fdOCT scans were obtained on 6 eyes of 6 patients with deep arcuate defects (5 points ≤−15 db) on 10-2 visual fields. The AO-SLO images were montaged and aligned with the fdOCT images to compare the RNF bundles seen with AO-SLO to the RNF layer thickness measured with fdOCT. Results: All 6 ...

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    5. The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

      The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

      P urpose To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) for neovascular age-related macular degeneration (nAMD): a comparison against fundus fluorescein angiography (FFA). Methods A retrospective review of SD-OCT, colour fundus photographs (FP), and FFA of 411 consecutive patients referred to a rapid access Macular Clinic over a 4-year period was performed. FFA images were reviewed nonstereoscopically. SD-OCT images were acquired using the Topcon 3D OCT-1000 instrument. All FFA and OCT images were graded by at least two ophthalmologists independently. Side-by-side grading took place with immediate open discussion and adjudication. If there was disagreement between the two ...

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    6. A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography

      A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography

      To present a case of an HIV-positive patient with acute exudative polymorphous vitelliform maculopathy (AEPVM) and evaluate the presence of specific spectral-domain optical coherence tomography (SD-OCT) findings. Case report. We reviewed the AEPVM cases reported in the literature and compared those to our patient to determine if there is a correspondence between the etiology that leads to the onset of AEPVM and clinical and SD-OCT findings. Acute exudative polymorphous vitelliform maculopathy is a disease that involves the outer retinal layers with lipofuscin deposits and serous detachment of the neuroepithelium with or without intraretinal cysts. Not much is known about the ...

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    7. In-vivo mapping of drusen by fundus autofluorescence and spectral-domain optical coherence tomography imaging

      In-vivo mapping of drusen by fundus autofluorescence and spectral-domain optical coherence tomography imaging

      Purpose To determine fundus autofluorescence (FAF) signal variations and corresponding microstructural alterations on spectral-domain optical coherence tomography (SD-OCT) in areas of funduscopically visible drusen associated with age-related macular degeneration (AMD). Methods Thirty eyes from 22 patients with geographic atrophy (GA) secondary to AMD (median age 74, range 64–87 years), who had undergone retinal imaging including color fundus photography (CFP), FAF and SD-OCT (Spectralis HRA+OCT; Heidelberg Engineering GmbH, Heidelberg, Germany) were retrospectively analyzed. In each eye, at least one druse (≥63 μm) in the perilesional zone of GA recorded on CFP was analyzed. Relative FAF intensities and alterations in ...

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    8. Swept source optical coherence tomography of the posterior vitreous after pars plana vitrectomy

      Swept source optical coherence tomography of the posterior vitreous after pars plana vitrectomy

      Dear Editor, Swept source optical coherence tomography (SS-OCT) visualizes deep structures such as the choroid, sclera, and most recently, the vitreous at the posterior pole [ 1 ]. With a light wavelength of 1050 nm and scanning speed of 100,000 Hz, SS-OCT has several advantages over spectral domain OCT (SD-OCT), including improved penetration through opacities, faster acquisition times while maintaining high-quality images, and a wider field than SD-OCT (12 mm vs. 6 mm) [ 2 – 4 ]. SS-OCT can provide helpful high-resolution imaging when looking at vitreous pathology [ 4 – 6 ]. Herein, we present two cases where SS-OCT was beneficial in evaluating the vitreous ...

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    9. Optical Devices in Ophthalmology and Optometry: Technology, Design Principles and Clinical Application (Textbook)

      Optical Devices in Ophthalmology and Optometry: Technology, Design Principles and Clinical Application (Textbook)

      Medical technology is a fast growing field. This new title gives a comprehensive review of modern optical technologies alongside their clinical deployment. It bridges the technology and clinical domains and will be suitable in both technical and clinical environments. It introduces and develops basic physical methods (in optics, photonics, and metrology) and their applications in the design of optical systems for use in medical technology with a special focus on ophthalmology. Medical applications described in detail demonstrate the advantage of utilizing optical-photonic methods. Exercises and solutions for each chapter help understand and apply basic principles and methods. An associated website ...

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    10. OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

      OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

      Purpose: White dot syndromes (WDS) are a group of inflammatory conditions characterized by white lesions at the retina and choroid level. Detection and monitoring of these syndromes are currently hampered by the subtlety of these lesions, making them difficult to image using traditional clinical techniques. New imaging modalities such as optical coherence tomography (OCT) and fundus autofluorescence (FAF) offer new opportunities for clinicians to noninvasively image WDS. Methods: A literature search was performed using a variety of WDS as the search terms. All articles from January 2004 to May 2014 were analyzed for clinical information regarding imaging of the diseases ...

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    11. Foveal Hypoplasia in Oculocutaneous Albinism and the Role of OCT

      Foveal Hypoplasia in Oculocutaneous Albinism and the Role of OCT

      We describe a case of a 16 year old girl with Oculocutaneous albinism (OCA) who presented to us with photophobia and blurring of vision. She showed typical features of OCA, blonde hair, refractive error, iris transillumination and foveal hypoplasia. Our report highlights the role of macular OCT in diagnosis of foveal hypoplasia which is an essential feature of OCA.

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    12. Correlation Between Visual Function and Photoreceptor Integrity in Diabetic Macular Edema: Spectral-Domain Optical Coherence Tomography

      Correlation Between Visual Function and Photoreceptor Integrity in Diabetic Macular Edema: Spectral-Domain Optical Coherence Tomography

      Purpose : To evaluate the relationship between visual function and (i) microstructural changes in the fovea of the inner segment-outer segment junction (IS/OS) and (ii) external limiting membrane (ELM) in diabetic macular edema (DME). Methods : We conducted a retrospective, observational, cross-sectional study of 40 DME patients (61 eyes), all of whom had been treated at Shanghai First People’s Hospital. Patients were divided into groups based on integrity of the IS/OS or ELM: IS/OS (+, ± and −) and ELM (+, ± and −). We performed best-corrected visual acuity (BCVA), MP1 microperimetry and spectral-domain optical coherence tomography (SD-OCT) on all patients. Several variables, including ...

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    13. COMPARISON OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY PARAMETERS BETWEEN CENTRAL RETINAL VEIN OCCLUSION AND NORMAL EYES: Is Primary Angle Closure a Risk Factor for Central Retinal Vein Occlusion?

      COMPARISON OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY PARAMETERS BETWEEN CENTRAL RETINAL VEIN OCCLUSION AND NORMAL EYES: Is Primary Angle Closure a Risk Factor for Central Retinal Vein Occlusion?

      Purpose: To compare anterior segment parameters in patients with central retinal vein occlusion (CRVO) with normal control subjects by anterior segment optical coherence tomography (AS-OCT). Methods: In this coss-sectional case-control study, 42 eyes from 21 patients with unilateral CRVO and 21 eyes from 21 age- and sex-matched healthy control subjects were recruited. Study eyes were divided into three groups: involved eyes of CRVO patients (CRVO eyes), fellow eyes of CRVO patients (fellow eyes), and control eyes. Complete ocular examination and AS-OCT were performed for each eye. The AS-OCT parameters (anterior chamber depth, scleral spur angle, angle opening distance [AOD] at ...

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    14. Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa

      Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa

      Purpose To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography. Methods An observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion. Results Fifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 ...

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    15. Dr. David Huang Joins the Research to Prevent Blindness (RPB) Scientific Advisory Board

      Dr. David Huang Joins the Research to Prevent Blindness (RPB) Scientific Advisory Board

      David Huang, MD, PhD, Peterson Professor of Ophthalmology and Professor of Biomedical Engineering at Oregon Health & Science University, has joined the Research to Prevent Blindness (RPB) Scientific Advisory Board. This will enhance the ability of RPB to evaluate imaging and engineering based grant applications. For information on RPB grant program, please see https://www.rpbusa.org/rpb/grants/grants/

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    16. Intraoperative OCT improves ophthalmic surgery

      Intraoperative OCT improves ophthalmic surgery

      The most popular examination method in ophthalmology today is optical coherence tomography (OCT ). Traditionally, OCT examinations have been performed pre- and post-operatively in vitreo-retinal surgery. While this application of the technology has enabled outcomes to be measured and results to be documented, surgeons have not had the ability to incorporate the results to improve surgical treatments. But with considerable advances to OCT—including high-definition OCT (HD OCT), 3D visualization , and adaptive optics —the integration of these methods into the surgical microscope is logical. The technology is now helping ophthalmologists carry out delicate eye surgeries. In today's integrated microscopy systems ...

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    17. Haag-Streit UK launch the Optovue AngioVue in the UK

      Haag-Streit UK launch the Optovue AngioVue in the UK

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce the launch of the AngioVue OCT Angiography (OCTA) system, in the UK. The AngioVue is the first commercial OCTA system capable of imaging and displaying the function of the ocular microvasculature, through a non-invasive procedure. The innovative system uses a unique dyeless technique to quickly evaluate the functional blood flow of the retina and optic nerve. This method allows the procedure to be performed in everyday clinical practice and unlike fluorescein angiography, can be repeated as often as required, and with no ...

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      Mentions: Optovue Haag-Streit
    18. Evaluation of retinal nerve fiber layer thickness measured by optical coherence tomography in Moroccan patients with multiple sclerosis

      Evaluation of retinal nerve fiber layer thickness measured by optical coherence tomography in Moroccan patients with multiple sclerosis

      Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal inflammatory infiltrates, demyelinating lesions and axonal injury. The purpose of the study was to evaluate the retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in Moroccan patients with MS and to assess the relationship between RNFL thickness and disease duration, Expanded Disability Status Scale (EDSS) score, visual acuity and automated visual field indices. Materials and methods Thirty-one patients with definite MS and thirty-one disease-free controls were enrolled in the study. After neurologic consultation, ophthalmologic examination including visual acuity, automated visual ...

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    19. Changes in Area of Conjunctiva and Tear Meniscus Measured Using Anterior Segment Optical Coherence Tomography after Conjunctivochalasis Surgery

      Changes in Area of Conjunctiva and Tear Meniscus Measured Using Anterior Segment Optical Coherence Tomography after Conjunctivochalasis Surgery

      Purpose To evaluate cross-sectional areas of conjunctiva and tear meniscus of conjunctivochalasis using Fourier-Domain RTVue-100 optical coherence tomography (OCT) before and after conjunctivochalasis surgery. Methods Thirty-one patients (33 eyes) with symptomatic conjunctivochalasis were recruited for this study between June 2013 and April 2014. All patients underwent crescent-shaped conjunctiva resection and amniotic membrane transplantation. Anterior segment OCT (AS-OCT) imaging was performed and tear break-up time was evaluated prior to and 3 months after the conjunctivochalasis surgery. Cross-sectional areas of conjunctiva and tear meniscus of conjunctivochalasis at 7 locations (1 center, 3 nasal and 3 temporal areas) were measured in all patients ...

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    20. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

      Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

      Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused ...

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    21. Study shows new technology may improve management of leading causes of blindness

      Study shows new technology may improve management of leading causes of blindness

      Research published today in the Proceedings of the National Academy of Sciences (PNAS) demonstrates that technology invented by researchers at Oregon Health & Science University's Casey Eye Institute can improve the clinical management of the leading causes of blindness. Optical coherence tomography (OCT) angiography could largely replace current dye-based angiography in the management of these diseases. OHSU researchers found that OCT angiography has considerable advantages over conventional techniques for the diagnosis and management of macular degeneration, diabetic eye disease and glaucoma, the leading causes of blindness in the United States. "This is a significant breakthrough technology that could fundamentally change ...

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    22. Swept Source Optical Coherence Tomography in Ocular Diseases Special Interest Group at ARVO

      Swept Source Optical Coherence Tomography in Ocular Diseases Special Interest Group at ARVO

      Moderators: Ludwig M. Heindl(Center of Ophthalmology, University Hospital Cologne, Cologne, Germany) Robert J. Zawadzki (UC Davis Eye Center, University of California Davis, Sacramento, California, US) Speakers: Olaf Meiendresch (Topcon Medical, Willich, Germany) Albert Caramoy (Center of Ophthalmology, University Hospital Cologne, Cologne, Germany) Robert J. Zawadzki (UC Davis Eye Center, Sacramento, USA) Ireneusz Grulkowski (Nicolaus Copernicus University, Torun, Poland Wolfgang Drexler (Medical University of Vienna, Vienna Austria) Robert Huber (Institute of Biomedical Optics, University zu Lübeck, Germany) Organizing Section: Anatomy and Pathology/Oncology (AP) Contributing Sections: Cornea (CO), Glaucoma (GL), Retina (RE), Multidisciplinary Ophthalmic Imaging Group (MOI) Imaging using ...

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    23. Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE

      Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE

      Objective Due to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE. Methods Retinal nerve fiber layer (RNFL) and macula scans were performed using SD-OCT on 15 NPSLE patients, 16 SLE patients without NP symptoms (non-NP SLE), and 16 healthy controls. Macular volume and thickness of the central macula and peripapillary RNFL were compared between the groups and to scores on two validated cognitive tests. Results NPSLE ...

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