1. Articles in category: Ophthalmology

    1-24 of 11508 1 2 3 4 ... 478 479 480 »
    1. Macular OCT-angiography parameters to predict the clinical stage of nonproliferative diabetic retinopathy: an exploratory analysis

      Macular OCT-angiography parameters to predict the clinical stage of nonproliferative diabetic retinopathy: an exploratory analysis

      Background To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. Methods Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with nonproliferative DR (up to ETDRS Level 53) were evaluated with OCTA (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Seven-field photographs of the fundus were taken for DR staging according to the ETDRS-grading scheme. The vessel density in the superficial and deep capillary plexus (SCP and DCP, respectively ...

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    2. Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Purpose: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula. Methods: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Best-corrected visual acuity assessment, standard Amsler grid test, biomicroscopic examination and macular spectral-domain optical coherence tomography were performed. Results: We examined three men and one woman, aged 56 to 91 years (average age: 75.25 years). Spectral-domain optical coherence tomography showed a hyperreflective central perpendicular line in five eyes accompanied by vitreofoveal adhesion in all of them ...

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    3. Optovue Launches New AngioWellness™ Scan at Vision Expo East

      Optovue Launches New AngioWellness™ Scan at Vision Expo East

      Optovue , the global leader in the development of optical coherence tomography (OCT) and OCT angiography (OCTA), will launch its new AngioWellness™ scan at Vision Expo East in New York , March 21-24, 2019 . The AngioWellness scan utilizes Optovue's advanced AngioVue ® OCTA technology to quickly assess and diagnose new pathologies in patients, including diabetic patients and those who may be at risk for glaucoma. Sample AngioWellness Report AngioWellness combines structural information on retinal and ganglion cell thickness with objective metrics on retinal vasculature into one easy-to-read report. The first of its kind patient-monitoring tool was designed to help eye care professionals ...

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      Mentions: Optovue
    4. Distance measuring device and method for measuring distances

      Distance measuring device and method for measuring distances

      A device for measuring a distance to an object comprises a beam splitter for splitting broadband coherent light emitted by a light source in measuring light which is guided through an object arm to the object to be measured and in reference light which is guided to a reference arm. The object arm includes a focusing optics with a focus movable along an optical axis of the object arm. The focusing optics comprises a movable optical element and is configured such that a movement of the movable optical element along the optical axis causes a higher movement of the focus ...

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    5. Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the ...

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    6. Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.

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    7. Interdisciplinary UCLA team wins funding for laser eye research

      Interdisciplinary UCLA team wins funding for laser eye research

      A n interdisciplinary team of UCLA engineers and medical professionals has won an award from the UCLA Innovation Fund for their work in advancing efforts to image structures of the eye using lasers. The endeavor is a collaboration between Kouros Nouri-Mahdavi , an assistant professor of ophthalmology in the glaucoma division of the UCLA Jules Stein Eye Institute, Chee Wei Wong , professor of electrical and computer engineering in the UCLA Samueli School of Engineering, and Jinghui Yang and Yoon-Soo Jang, two research scientists in Wong’s lab . Organized by the UCLA Technology Development Group, the UCLA Innovation Fund ’s goal is ...

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    8. Longitudinal changes in outer nuclear layer thickness in soft drusen and reticular pseudodrusen

      Longitudinal changes in outer nuclear layer thickness in soft drusen and reticular pseudodrusen

      Background Drusen are seen in the early and intermediate stages of age‐related macular degeneration. A retrospective, two‐year observational study at a tertiary centre was designed to assess outer nuclear layer thickness in different types of drusen. Methods Patients over 50 years of age with predominant soft drusen or reticular pseudodrusen were included in the study. Fundus photography, infrared, fundus autofluorescence and spectral domain optical coherence tomography were performed at baseline, years one and two. Outer nuclear layer thickness was measured in the nine Early Treatment Diabetic Retinopathy Study subfields, and the rate of thinning was determined using generalised ...

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    9. Repeatability of wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Repeatability of wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Background To examine the repeatability of choroidal thickness measurements across a 55° field, in a sample of healthy young adults using wide‐field enhanced‐depth imaging optical coherence tomography. Methods High‐resolution wide‐field volumetric enhanced‐depth imaging scans were obtained from the right eye of 27 adults (mean age 27 ± 5 years) during two sessions, separated by 19 ± 15 days, using the follow‐up feature of the Spectralis instrument, while controlling for confounding factors known to influence choroidal thickness. Semi‐automatic segmentation of the choroidal boundaries was corrected by a single masked observer. This process was repeated on images ...

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    10. Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography

      Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography

      Purpose To investigate the potential of handheld optical coherence tomography (HH-OCT) in assessing the anterior segment of the eye in patients with primary congenital glaucoma. Design A prospective, case-controlled observational study. Participants Twenty-two patients with primary congenital glaucoma (PCG, 9 females and 13 males; mean age 4.36 ± 3.4 years) and age-, gender- and ethnicity-matched healthy participants. Methods Anterior OCT was performed in all participants using a high-resolution HH SD-OCT device (Envisu 2300, Leica Microsystems, Germany) without anaesthesia or sedation. Results Anterior HH-OCT in PCG visualised Haab’s striae in 14.3%, uneven internal cornea in 9.5% and ...

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    11. Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Purpose: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). Methods: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV). Results: ICCs for the macular VD measurements in ...

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    12. Optical coherence elastography of cold cataract in porcine lens

      Optical coherence elastography of cold cataract in porcine lens

      Cataract is one of the most prevalent causes of blindness around the world. Understanding the mechanisms of cataract development and progression is important for clinical diagnosis and treatment. Cold cataract has proven to be a robust model for cataract formation that can be easily controlled in the laboratory. There is evidence that the biomechanical properties of the lens can be significantly changed by cataract. Therefore, early detection of cataract, as well as evaluation of therapies, could be guided by characterization of lenticular biomechanical properties. In this work, we utilized optical coherence elastography (OCE) to monitor the changes in biomechanical properties ...

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    13. Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition

      Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition

      Defocusing, vignetting, and bulk motion degrade the image quality of optical coherence tomography angiography (OCTA) more significantly than structural OCT. The assessment of focus, alignment conditions, and stability of imaging subjects in commercially available OCTA systems are currently based on OCT signal quality alone, without knowledge of OCTA signal quality. This results in low yield rates for further quantification. In this Letter, we developed a novel OCTA platform based on a graphics processing unit (GPU) for a real-time, high refresh rate, B-san-by-B-scan split-spectrum amplitude-decorrelation angiography. The GPU provides a real-time display of both cross-sectional and en face images to assist ...

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    14. Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

      Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

      Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the treatment could exacerbate choriocapillary rarefaction, necessitating advanced treatment for fundamental recovery from NV-AMD. In this study, Tie2 activation by angiopoietin-2–binding and Tie2-activating antibody (ABTAA) presents a therapeutic strategy for NV-AMD. Conditional Tie2 deletion impeded choriocapillary maintenance, rendering eyes susceptible to NV-AMD development. Moreover, in a NV-AMD mouse model, ABTAA not only suppressed choroidal neovascularization (CNV) and vascular leakage but ...

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    15. Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

      Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

      Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. Furthermore, this imaging modality has been widely adopted to investigate different ocular and systemic diseases. In this review, a discussion of the fundamental principles of OCTA is followed by the application of this imaging modality to study the retinal and choroidal vessels. A proper comprehension of this imaging modality is essential for the interpretation of OCTA imaging applications in retinal and choroidal disorders.

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    16. Optical Coherence Tomography Angiography of Retinal-Choroidal Anastomosis in Toxoplasmosis Chorioretinitis

      Optical Coherence Tomography Angiography of Retinal-Choroidal Anastomosis in Toxoplasmosis Chorioretinitis

      A young adult was examined for follow-up of toxoplasmosis chorioretinitis that was diagnosed and treated during early childhood. Two subsequent flare-ups were treated with atovaquone, combined trimethoprim and sulfamethoxazole, and oral prednisone. Visual acuity was 20/20 OD. Ophthalmoscopic examination results demonstrated an inactive temporal chorioretinal scar with an apparent retinal-choroidal anastomosis ( Figure ). Optical coherence tomography angiography was performed through the anastomosis. Enface images ( Figure ) of the retinal and choroidal circulations confirmed that there was an anastomotic flow between the retinal venous and choroidal circulations ( Figure ). We postulate that this anastomosis resulted from the structural damage that was caused by ...

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    17. Foveal Neovascularization Detected by Optical Coherence Tomography Angiography in Incontinentia Pigmenti

      Foveal Neovascularization Detected by Optical Coherence Tomography Angiography in Incontinentia Pigmenti

      A 5-year-old girl received a diagnosis of incontinentia pigmenti by skin biopsy results. Her best-corrected visual acuity was 20/32 OD. Fluorescein angiography showed nonperfusion and leakage from neovascularization (NV) in the temporal peripheral retina in that eye. Optical coherence tomography (OCT) angiography results showed foveal NV and parafoveal capillary nonperfusion ( Figure ). Another OCT image demonstrated inner retinal thinning that corresponded to the region of parafoveal capillary nonperfusion. Scatter laser photocoagulation was applied to the peripheral nonperfusion areas of the retina.

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    18. Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Purpose Binarization is a critical technique in OCTA image analysis, but there is no consistency in the method used in published OCTA studies. This study assessed whether differences in OCTA binarization and brightness/contrast adjustments affect quantification metrics. Design Prospective cross-sectional validity study Methods This was a single-center study examining 21 eyes of 11 healthy individuals. All eyes were imaged using the Carl Zeiss PLEX Elite 9000 swept source-OCTA, and quantitative metrics resulting from five binarization thresholding and five brightness/contrast adjustment methodologies were compared. All metrics were calculated for the superficial plexus and choriocapillaris (CC), as well as unaveraged ...

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    19. Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study

      Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study

      Objective To determine the optimal thresholds for inter‐eye differences in retinal nerve fiber and ganglion cell+inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Background Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multi‐center international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected ...

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    20. Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome

      Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome

      Purpose: To report a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome and the changes seen in the optical coherence tomography angiography before and after treatment with eculizumab. Case description: A 22-year-old man with an unremarkable medical history presented with acute, bilateral blurred vision and headache of 1-week duration. Best corrected visual acuity of 20/50 and 20/40, respectively, in the patient’s right eye and left eye. Funduscopy revealed multiple cotton-wool spots associated with intrarretinal fluid. Swept source optical coherence tomography revealed multifocal retinal detachments with increased choroidal thickness. Optical coherence tomography angiography showed areas of ...

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    21. Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time

      Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time

      Précis: There are errors in automated segmentation of the retinal nerve fiber layer in glaucoma suspects or patients with mild glaucoma that appear to persist over time; however, automated segmentation has greater repeatability than manual segmentation. Purpose: To identify whether optical coherence tomography (OCT) segmentation errors in retinal nerve fiber layer (RNFL) thickness measurements persist longitudinally. Methods: This was a cohort study. We used spectral domain OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) to measure RNFL thickness in a 6-degree peripapillary circle, and exported the native “automated segmentation only” results. In addition, we exported RNFL thickness results after “manual refinement ...

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    22. Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      A postdoctoral research fellow position is available in the Center for Ophthalmic Optics & Lasers Lab ( www.coollab.net ), Casey Eye Institute, Oregon Health & Science University. This is an outstanding opportunity for a candidate to use optical coherence tomography to conduct visual optics research in an academic ophthalmology setting. The researcher on this position will work with a team of scientists, engineers and physicians to develop ultrahigh-performance OCT systems for comprehensive optical characterization of the anterior eye and wide-field ocular surface topography, to improve post-refractive surgery intraocular lens power calculation, therapeutic scleral lens design, diagnosis and classification of corneal shape irregularities ...

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    23. Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography

      Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography

      We demonstrate the advantages of optical coherence tomography (OCT) imaging for investigation of spontaneous retinal venous pulsation (SRVP). The pulsatile changes in venous vessel caliber are analyzed qualitatively and quantitatively using conventional intensity-based OCT as well as the functional extension Doppler OCT (DOCT). Single-channel and double-channel line scanning protocols of our multi-channel OCT prototype are employed to investigate venous pulsatile caliber oscillations as well as venous flow pulsatility in the eyes of healthy volunteers. A comparison to recordings of scanning laser ophthalmoscopy (SLO) – a standard en-face imaging modality for evaluation of SRVP – is provided, emphasizing the advantages of tomographic image ...

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