1. Articles in category: Ophthalmology

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    1. Optovue’s AngioVue Imaging System Receives FDA Clearance

      Optovue’s AngioVue Imaging System Receives FDA Clearance

      Optovue, the global leader in the development and commercialization of optical coherence tomography angiography (OCTA), today announced FDA clearance and immediate U.S. commercial availability of the AngioVue™** Imaging System, a groundbreaking technology that provides a non-invasive way to visualize abnormal blood vessels to help physicians determine an appropriate course of treatment. “We are thrilled to announce FDA clearance of our AngioVue System, which will bring the significant benefits of our innovative, non-invasive retinal imaging to patients in the U.S. who suffer from retinal diseases that lead to progressive blindness,” said Jay Wei, founder and chief executive officer at ...

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      Mentions: Optovue Jay Wei FDA
    2. Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000

      Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000

      Background Optical coherence tomography (OCT), can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance. Methods Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. Repeatability was evaluated by use of the coefficient of repeatability (CR) and the coefficient of repeatability as a percentage of the mean (CR ...

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    3. Glaucoma Tube Changes After Suture Lysis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography

      Glaucoma Tube Changes After Suture Lysis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography

      This Ophthalmic Image shows swept-source optical coherence tomography of glaucoma tube changes after Baerveldt glaucoma implant into the ciliary sulcus. A woman developed Takayasu disease and neovascular glaucoma in her early 20s. She underwent cardiovascular bypass surgery, but lost vision in her left eye. When another cardiovascular bypass was planned in her mid-40s, 95% of her right eye angle was closed, but her intraocular pressure (IOP) did not exceed the high teens while receiving glaucoma medications, probably because of reduced ocular circulation. 1 In preparation for the IOP increase with circulation improvement, we performed a Baerveldt glaucoma implant into the ...

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    4. Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration

      Purpose To determine whether angiography with swept-source (SS) optical coherence tomography (OCT) identifies subclinical type 1 neovascularization in asymptomatic eyes with intermediate age-related macular degeneration (iAMD). Design Prospective, observational, consecutive case series. Participants Patients with asymptomatic iAMD in one eye and neovascular age-related macular degeneration (AMD) in their fellow eye. Methods The patients underwent SS OCT angiography (OCTA), fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the images from these 3 angiographic techniques were compared. Main Outcome Measures Identification of subclinical type 1 neovascularization with SS OCTA in asymptomatic eyes with iAMD. Results Eleven consecutive patients with iAMD in ...

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    5. The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT

      The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT

      Purpose To determine whether retinal nerve fiber layer (RNFL), macula and macular ganglion cell layer (mGCL)-inner plexiform layer (IPL) thickness differ in the amblyopic and normal fellow eyes of unilateral amblyopic patients using spectral domain optical coherence tomography (SD-OCT). Methods 80 patients with 160 eyes were included in this study; the distribution of patients was 17 patients with strabismic amblyopia, 17 patients with strabismic non-amblyopia, 23 patients with anisometropic amblyopia, and 23 patients with anisometropic non-amblyopia. Macular, RNFL, and mGCL-IPL thickness were obtained by SD-OCT, and the interocular thickness differences of each group were analyzed. After treatment, the changes ...

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    6. Macular Choroidal Thickness and Volume Measured by Swept-source Optical Coherence Tomography in Healthy Korean Children

      Macular Choroidal Thickness and Volume Measured by Swept-source Optical Coherence Tomography in Healthy Korean Children

      Purpose To evaluate the thickness and volume of the choroid in healthy Korean children using swept-source optical coherence tomography. Methods We examined 80 eyes of 40 healthy children and teenagers (<18 years) using swept-source optical coherence tomography with a tunable long-wavelength laser source. A volumetric macular scan protocol using the Early Treatment Diabetic Retinopathy Study grid was used to construct a choroidal thickness map. We also examined 44 eyes of 35 healthy adult volunteers (≥18 years) and compared adult measurements with the findings in children. Results The mean age of the children and teenagers was 9.47 ± 3.80 (4 ...

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    7. Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis

      Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis

      Purpose To analyze the structural and morphological characteristics of retinal astrocytic hamartomas in tuberous sclerosis patients using fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography. Case summary Fundus examination, fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography were performed in three patients with tuberous sclerosis and the morphological and structural characteristics of retinal astrocytic hamartomas were analyzed. In the fundus autofluorescence, type 1 retinal astrocytic hamartoma showed hypofluorescence and type 3 showed central hyperfluorescence and surrounding hypofluorescence. Spectral domain optical coherence tomography showed dome-shaped hyper-reflectivity within the nerve fiber layer and focal adhesion of the vitreous cortex in ...

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    8. Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems

      Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems

      PURPOSE: To compare corneal thickness measurements between three imaging systems. METHODS: In this retrospective study of 81 virgin and 58 post-laser refractive surgery corneas, central and minimum corneal thickness were measured using optical coherence tomography (OCT), very high-frequency digital ultrasound (VHF digital ultrasound), and a Scheimpflug imaging system. Agreement between methods was analyzed using mean differences (bias) (OCT – VHF digital ultrasound, OCT – Scheimpflug, VHF digital ultrasound – Scheimpflug) and Bland–Altman analysis with 95% limits of agreement (LoA). RESULTS: Virgin cornea mean central corneal thickness was 508.3 ± 33.2 µ m (range: 434 to 588 µ m) for OCT, 512.7 ± 32 ...

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    9. Repeatability and Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements of Retinal Thickness in Rats

      Repeatability and Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements of Retinal Thickness in Rats

      Purpose : To evaluate the in vivo repeatability and reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurements of total retinal thickness (TRT) and retinal nerve fiber layer (RNFL) thickness in rats. Methods : Retinal thickness was measured using an RNFL circular scan with AutoRescan and TruTracking modes in 20 eyes of Long-Evans Tokushima Otsuka rats. Three RNFL circular scan images were acquired with a brief rest between measurements to evaluate intra-session repeatability. Three additional RNFL circular scans were acquired 1 day later to evaluate intersession repeatability. Two experienced examiners independently measured TRT using automatic alignment and RNFL thickness using manual alignment according ...

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    10. Macular Thickness in Myopia: An OCT Study of Young Chinese Patients

      Macular Thickness in Myopia: An OCT Study of Young Chinese Patients

      Purposes : To investigate macular thickness (MT) in young myopic Chinese patients using Spectralis optical coherence tomography (OCT) and to assess its association with gender, axial length (AL), spherical equivalent (SE), and intraocular pressure (IOP). Methods : Included in this study were 133 myopic Chinese patients, aged 18–30 years. All underwent complete ophthalmic examinations and Spectralis OCT. Inner, central, and outer foveal regions of the macula were measured. Results : The central fovea was the thinnest of the three macular regions (mean thickness, 250.1 ± 15.3 μm). Women had consistently thinner MTs than did men, except in the outer superior and ...

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    11. A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      Purpose/Aim : Pseudotumor cerebri, or idiopathic intracranial hypertension (IIH), is characterized by increased intracranial pressure of unknown etiology. A subset of patients has shown benefit from endovascular dural venous sinus stenting (DVSS). We sought to identify a population of IIH patients who underwent DVSS to assess outcomes. Materials and Methods : A retrospective study was performed to identify IIH patients with dural sinus stenosis treated with DVSS. Outcome measures included dural sinus pressure gradients, peripapillary retinal nerve fiber layer thickness using optical coherence tomography, and improvement in symptoms. Results : Seventeen patients underwent DVSS. Average pre- and post-intervention pressure gradients were 23 ...

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    12. Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Purpose To investigate the profile and determinants of retinal optical intensity in normal subjects using 3D spectral domain optical coherence tomography (SD OCT). Methods A total of 231 eyes from 231 healthy subjects ranging in age from 18 to 80 years were included and underwent a 3D OCT scan. Forty-four eyes were randomly chosen to be scanned by two operators for reproducibility analysis. Distribution of optical intensity of each layer and regions specified by the Early Treatment of Diabetic Retinopathy Study (ETDRS) were investigated by analyzing the OCT raw data with our automatic graph-based algorithm. Univariate and multivariate analyses were ...

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    13. Zeiss AngioPlex Optical Coherence Tomography Angiography of the Retinal Microvasculature May Help Enhance Understanding of Retinal Diseas

      Zeiss AngioPlex Optical Coherence Tomography Angiography of the Retinal Microvasculature May Help Enhance Understanding of Retinal Diseas

      AngioPlexTM optical coherence tomography (OCT) is a new approach to diagnostic imaging in retinal disease. This technology uses amplitude and phase aspects of the OCT signal and novel algorithms to enable highly detailed visualisation of the retinal microvasculature. This system detects capillary flow rather than the presence of an injected dye. Unlike fluorescein angiography (FA), AngioPlex OCT imaging can discriminate capillaries at the superficial and deep retina and can also generate a colour map of the retinal vessels providing unparalleled views of diseased capillaries and net structures. Retinal and choroidal pathologies that are amenable to AngioPlex OCT examination include diabetic ...

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      Mentions: FDA
    14. Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Background: A cross-sectional study to investigate the morphological and functional changes of the visual pathway, taking place in patients with migraine. Methods: Fifteen patients (14 female, 1 male) diagnosed with migraine with aura (MA group) and 23 patients (21 female, 2 male) diagnosed with migraine without aura (MO group) were compared to 20 healthy volunteers (18 Female, 2 male). All the participants underwent optical coherence tomography (OCT) scan, electroretinogram (ERG), visual evoked potentials (VEP), and multifocal electroretinogram (mf-ERG) recording. Results: Assessing ERG recordings, no significant differences in mean N1-P1 amplitudes were measured among the groups. The mean VEP N80-P100 amplitudes ...

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    15. Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography

      Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography

      AIM : To assess quantitative changes of the macula in diabetic eyes after cataract surgery using optical coherence tomography (OCT) and to estimate the incidence of development or worsening of macular edema (ME) in diabetic eyes with or without pre-existing ME. METHODS : In this prospective, observational study, 92 eyes of 60 diabetic patients who underwent cataract surgery were evaluated before surgery and 1, 3mo after surgery using OCT. Macular thickness was measured with OCT at nine macular subfields defined by the 9 zones early treatment of diabetic retinopathy study (ETDRS), as well as total macular volume obtained by OCT at 1 ...

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    16. Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

      Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

      Dear Sir, I write to present the correlation between microperimetric (MP) values and the density of myelinated retinal nerve fibers (MNFs) in optical coherence tomography (OCT) imaging. MNFs appear as white or gray-white striated patches that correspond in shape to the distribution of retinal nerve fibers and demonstrate frayed borders[1] . Visual system myelination normally begins at the optic tracts at 7mo of gestational age and progresses anteriorly, finishing within 3mo after birth and stopping at the lamina cribrosa. However, this process may progress beyond this level and cause retinal nerve fibers to become myelinated [2-4] . The incidence of MNFs ...

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    17. Optical Coherence Tomography Angiography of the Retinal Microvasculature using the Zeiss AngioPlex

      Optical Coherence Tomography Angiography of the Retinal Microvasculature using the Zeiss AngioPlex

      AngioPlex optical coherence tomography (OCT) is a new approach to diagnostic imaging in retinal disease. This technology uses amplitude and phase aspects of the OCT signal and novel algorithms to enable highly detailed visualisation of the retinal microvasculature. This system detects capillary flow rather than the presence of an injected dye. Unlike fluorescein angiography (FA), AngioPlex OCT imaging can discriminate capillaries at the superficial and deep retina and can also generate a colour map of the retinal vessels providing unparalleled views of diseased capillaries and net structures. Retinal and choroidal pathologies that are amenable to AngioPlex OCT examination include diabetic ...

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      Mentions: FDA
    18. Retinal Imaging Techniques for Diabetic Retinopathy Screening

      Retinal Imaging Techniques for Diabetic Retinopathy Screening

      Due to the increasing prevalence of diabetes mellitus, demand for diabetic retinopathy (DR) screening platforms is steeply increasing. Early detection and treatment of DR are key public health interventions that can greatly reduce the likelihood of vision loss. Current DR screening programs typically employ retinal fundus photography, which relies on skilled readers for manual DR assessment. However, this is labor-intensive and suffers from inconsistency across sites. Hence, there has been a recent proliferation of automated retinal image analysis software that may potentially alleviate this burden cost-effectively. Furthermore, current screening programs based on 2-dimensional fundus photography do not effectively screen for ...

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    19. A pilot study to image the vascular network of small melanocytic choroidal tumors with speckle noise-free 1050-nm swept source optical coherence tomography (OCT choroidal angiography)

      A pilot study to image the vascular network of small melanocytic choroidal tumors with speckle noise-free 1050-nm swept source optical coherence tomography (OCT choroidal angiography)

      Purpose To visualize and measure the vascular network of melanocytic choroidal tumors with speckle noise-free swept source optical coherence tomography (SS-OCT choroidal angiography). Methods Melanocytic choroidal tumors from 24 eyes were imaged with 1050-nm optical coherence tomography (Topcon DRI OCT-1 Atlantis). A semi-automated algorithm was developed to remove speckle noise and to extract and measure the volume of the choroidal vessels from the obtained OCT data. Results In all cases, analysis of the choroidal vessels could be performed with SS-OCT without the need for pupillary dilation. The proposed method allows speckle noise-free, structure-guided visualization and measurement of the larger choroidal ...

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    20. A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal “tumoropsy”)

      A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal “tumoropsy”)

      Purpose The purpose was to illustrate small melanocytic choroidal tumors with speckle-noise free swept-source optical coherence tomography (SSOCT). Methods Twenty-five small melanocytic choroidal tumors in 24 eyes underwent 1050 nm OCT. All tumors were measured manually with the built-in caliper tool and compared to data derived from a semiautomated algorithm that removed speckle noise but preserved the structure of the tumors from the SSOCT data. Results The average manual measurements for the horizontal, vertical, and axial diameters were 1535.28 μm (range, 547–2807 μm), 1713.8 μm (range, 574–3921 μm), and 227.28 μm (range, 115–489 μm ...

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    21. Subfoveal choroidal thickness in eyes with diabetic macular oedema using swept source optical coherence tomography

      Subfoveal choroidal thickness in eyes with diabetic macular oedema using swept source optical coherence tomography

      Purpose To compare subfoveal choroidal thickness (GCSF) in patients with diabetic macular oedema (DMO) and healthy subjects using swept source optical coherence tomography (SS-OCT). Method Cross-sectional study including 50 eyes of 36 patients with DMO, and 47 eyes of 34 patients as a control group. GCSF was measured in both groups, analysing between the eyes with DMO according to the type of oedema (predominantly cystic or diffuse). Results The study groups were homogeneous in terms of mean age (63.4 years for DMO and 62.65 years for controls; P =.36) and the mean axial length (23.21 mm for ...

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    22. Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Purpose To describe the use of a novel intra-ocular side-scanning probe enabling the acquisition of spectral-domain optical coherence tomography (SD-OCT) images during surgery in a series of patients with complex forms of retinal detachment. Methods A 23-gauge, side-scanning SD-OCT probe (C7 System; LightLab Imaging, Inc/St Jude Medical, St. Paul, MN, USA) in a 20-gauge catheter, was used to acquire the intra-operative OCT images in seven patients with vitreoretinal diseases. Twenty-five gauge pars plana vitrectomy (PPV) was performed in every patient in a standard fashion. After enlarging the temporal sclerotomy to a 20-gauge port, all the patients were scanned with ...

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    23. Segmentation Errors in Macular Ganglion Cell Analysis as Determined by Optical Coherence Tomography

      Segmentation Errors in Macular Ganglion Cell Analysis as Determined by Optical Coherence Tomography

      Purpose To investigate the prevalence, features, associated factors, and reproducibility of segmentation errors in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement as determined by optical coherence tomography (OCT). Design Cross-sectional study. Participants Five hundred thirty-eight glaucomatous and healthy eyes from 290 subjects with OCT-measured macular GCIPL thickness were enrolled. Eyes with macular disorders, including epiretinal membrane, macular degeneration, macular hole, and myopic maculopathy, were excluded. Methods By inspecting 128 cross-sectional OCT B-scan images per eye, the presence (yes vs. no), layer (anterior vs. posterior border), location (quadrants), and area (diffuse vs. focal) of macular GCIPL segmentation error were ...

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    24. Macular Changes Following Strabismus Surgery Confirmed by the Use of Optical Coherence Tomography

      Macular Changes Following Strabismus Surgery Confirmed by the Use of Optical Coherence Tomography

      Although temporary changes in corneal curvature following strabismus surgery have been described, there has been little known about macular changes occurring as well. Optical coherence tomography (OCT) can detect even subclinical postoperative changes. In this issue, Mintz et al. have documented subclinical increases in the foveal and perifoveal macular thickness following strabismus surgery using OCT. The etiology of these OCT findings is currently unclear. Perhaps, as expressed by the authors, it might be due to changes in the mechanical forces or postoperative inflammation and changes in the blood–retinal barrier. The macular thickness changes following strabismus surgery were relatively small ...

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