1. Articles in category: Ophthalmology

    1-24 of 12918 1 2 3 4 ... 537 538 539 »
    1. Assessment of primary open-angle glaucoma peripapillary and macular choroidal area using enhanced depth imaging optical coherence tomography

      Assessment of primary open-angle glaucoma peripapillary and macular choroidal area using enhanced depth imaging optical coherence tomography

      Purpose The current study investigated differences in the peripapillary and macular choroidal areas between patients with primary open-angle glaucoma (POAG) and healthy controls because the choroid may potentially play a role in glaucoma pathophysiology. Methods We assessed 57 healthy controls and 42 POAG patients in a cross-sectional comparative study. We used enhanced depth imaging optical coherence tomography (EDI-OCT) and then converted the luminal and interstitial areas to binary images using the Niblack method to obtain peripapillary and macular choroidal images. The relationship between the choroidal area and demographic and ocular characteristics were determined with univariate and multivariate linear regression analysis ...

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    2. Factors Affecting Repeatability of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography in Pathologic Eyes

      Factors Affecting Repeatability of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography in Pathologic Eyes

      Purpose: To determine factors that may affect the repeatability of the foveal avascular zone (FAZ) measurement obtained using optical coherence tomography angiography (OCTA) including instrument type, image segmentation, image quality, and fundus pathology. Patients and Methods: This prospective single-center study enrolled 43 subjects (85 eyes) with retinal vasculopathy, macular edema, optic pathology or normal contralateral eye. The macula was imaged twice using Optovue Angiovue and once using Cirrus Angioplex to obtain 3x3mm OCTA images centered on the fovea. Images were generated by the same operator within 30 mins. The FAZ size for the entire retinal thickness (“overall FAZ”) was measured ...

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    3. Macular choroidal thickness in patients with pseudoxanthoma elasticum measured by enhanced-depth imaging spectral-domain optical coherence tomography

      Macular choroidal thickness in patients with pseudoxanthoma elasticum measured by enhanced-depth imaging spectral-domain optical coherence tomography

      Background/objectives To analyze macular choroidal thickness in patients with pseudoxanthoma elasticum (PXE) by enhanced depth imaging optical coherence tomography (EDI-OCT). Subjects/methods This is a prospective cross-sectional study. Sixty-eight eyes of 34 patients with PXE and 68 normal eyes of 34 controls were included to study the macular area with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). Eyes with PXE were classified in three groups: those without choroidal neovascularization (CNV) or chorioretinal macular atrophy macular (Group 1); those with active CNV (Group 2) and those with macular atrophy secondary to inactive CNV (Group 3). Results Mean subfoveal choroidal ...

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    4. The use of anterior segment optical coherence tomography in evaluation of punctal stenosisL’utilisation de l’OCT-SA dans la sténose du point lacrymal

      The use of anterior segment optical coherence tomography in evaluation of punctal stenosisL’utilisation de l’OCT-SA dans la sténose du point lacrymal

      Purpose To evaluate the applicability of anterior segment optical coherence tomography (AS-OCT) for objective diagnosis of punctal stenosis. Methods We report the use of AS-OCT in 3 cases of epiphora related to punctal stenosis. We followed the methodology described in previous studies. The examination was performed by a single technician using a single Spectralis OCT with the AS-OCT module. Three patients with complaints of epiphora (mean age = 80 years) were examined. The external punctal diameter was measured on both infrared (IR) and OCT images. The internal diameter was measured on OCT images at a depth of 500 μm. The diagnosis ...

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    5. Using optical coherence tomography angiography in assessment of the anti-vascular endothelial growth factor effect for pathological vascular tissue in age-related macular degeneration and polypoidal choroidal vasculopathy

      Using optical coherence tomography angiography in assessment of the anti-vascular endothelial growth factor effect for pathological vascular tissue in age-related macular degeneration and polypoidal choroidal vasculopathy

      Purpose: Using optical coherence tomography angiography to assess and compare changes in pathological vascular tissue, including choroidal neovascularization in neovascular age-related macular degeneration and polypoidal complex in polypoidal choroidal vasculopathy, after treatment with anti-vascular endothelial growth factor. Methods: This is a retrospective observational case series study. Clinical data were collected, including that on the best-corrected visual acuity and images of spectrum domain optical coherence tomography and optical coherence tomography angiography of consecutive patients with macula-involved lesions, active pathological vascular tissue in neovascular age-related macular degeneration, and polypoidal complex in polypoidal choroidal vasculopathy who were treated with anti-vascular endothelial growth factor ...

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    6. Repeatability of Manual Measurement of Foveal Avascular Zone Area in Optical Coherence Tomography Angiography Images in High Myopia

      Repeatability of Manual Measurement of Foveal Avascular Zone Area in Optical Coherence Tomography Angiography Images in High Myopia

      Purpose To analyze the repeatability of manual measurement of foveal avascular zone (FAZ) area in an optical coherence tomography angiography (OCTA) image in high myopia. Methods This study comprised patients with high myopia and controls. Two consecutive FAZ areas of the superficial and deep capillary plexus were obtained using OCTA. The intraclass correlation coefficient (ICC) and coefficient of variation (CV) were assessed, and univariate and multivariate generalized linear mixed models were conducted to identify factors related to repeatability. Results Thirty eyes with high myopia and 34 eyes of healthy subjects were included in the study. The mean age in high ...

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    7. Fluorescein angiography versus optical coherence tomography angiography: FA vs OCTA Italian Study

      Fluorescein angiography versus optical coherence tomography angiography: FA vs OCTA Italian Study

      Purpose: To assess the current role of fluorescein angiography after the introduction of optical coherence tomography angiography in real-life clinical practice. Methods: This was a multicentric retrospective observational study to evaluate the number of fluorescein angiography and optical coherence tomography angiography procedures performed by different devices from January 2013 to December 2018. The centers involved were Centro Italiano Macula (Rome), and ophthalmology departments of University “G. D’Annunzio” Chieti–Pescara (Chieti) and “Azienda Ospedaliero Universitaria Careggi” (Florence). Results: Out of 19,898 total fluorescein angiography procedures performed in the observation period, 3444 (17.3%) were in 2013, 3972 (19.9 ...

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    8. Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography

      Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography

      Background/aims To evaluate diurnal variations in optic nerve head (ONH) vessel density assessed by optical coherence tomography angiography (OCT-A) in healthy subjects, ocular hypertension (OHT), and open-angle glaucoma (OAG) patients. Methods Forty subjects (OAG, 21; OHT, 6; healthy, 13) were assessed for vessel density percentage (VD%) and flow index in the ONH (NH VD%, NH index), and in the radial peripapillary capillary layer (RPC VD%, RPC index) at 9:00, 11:00, 14:00, 16:00, and 18:00 on a single day. Repeated measures ANOVAs were used to test for changes in the parameters measured at multiple time ...

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    9. Biomarkers in Usher syndrome: ultra-widefield fundus autofluorescence and optical coherence tomography findings and their correlation with visual acuity and electrophysiology findings

      Biomarkers in Usher syndrome: ultra-widefield fundus autofluorescence and optical coherence tomography findings and their correlation with visual acuity and electrophysiology findings

      Purpose To investigate the functional and structural biomarkers and their correlation with Usher syndrome (USH). Methods Medical records, imaging and electrophysiology test results of USH patients attending the Save Sight Institute between 2012 and 2017 were reviewed. Best corrected visual acuity (BCVA), ultra-widefield autofluorescence (UW-FAF), spectral-domain optical coherence tomography (SD-OCT), full-field electroretinogram and pattern electroretinogram (pERG) were performed. SD-OCT scans assessed central macular thickness (CMT), greatest linear diameter of preserved outer retinal layers—macular island (MI) and presence of cystoid macular edema (CME). UW-FAF images were qualitatively graded to identify hypo/hyperfluorescence patterns in the peripheral fundus. Results Thirty-six eyes ...

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    10. Researchers find additional uses for OCT, ERG technologies

      Researchers find additional uses for OCT, ERG technologies

      Research continues to reveal additional uses for evolving technology in the realm of OCT and ERG. These diagnostic tools offer eye care providers noninvasive means to determine signs and features of retinal impairment to better inform prognosis and treatment. Details from a cross-sectional study published in Ophthalmology showed that patients with OCT images displaying a shallow, irregular retinal pigment epithelium elevation (SIRE) sign had a higher risk for nonexudative macular neovascularization (NE-MNV) and neovascular age-related macular degeneration. “SIRE can be detected on the more ubiquitously available structural OCT B-scans and indicate eyes at higher risk of NE-MNV and, thus, subsequently ...

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      Mentions: Optovue Alcon
    11. Imaging retinal structures at cellular-level resolution by visible-light optical coherence tomography

      Imaging retinal structures at cellular-level resolution by visible-light optical coherence tomography

      In vivo high-resolution images are the most direct way to understand retinal function and diseases. Here we report the use of visible-light optical coherence tomography with volumetric registration and averaging to achieve cellular-level retinal structural imaging in a rat eye, covering the entire depth of the retina. Vitreous fibers, nerve fiber bundles, and vasculature were clearly revealed, as well as at least three laminar sublayers in the inner plexiform layer. We also successfully visualized ganglion cell somas in the ganglion cell layer, cells in the inner nuclear layer, and photoreceptors in the outer nuclear layer and ellipsoid zone. This technique ...

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    12. Intraretinal Fluid Pattern Characterization in Optical Coherence Tomography Images

      Intraretinal Fluid Pattern Characterization in Optical Coherence Tomography Images

      Optical Coherence Tomography (OCT) has become a relevant image modality in the ophthalmological clinical practice, as it offers a detailed representation of the eye fundus. This medical imaging modality is currently one of the main means of identification and characterization of intraretinal cystoid regions, a crucial task in the diagnosis of exudative macular disease or macular edema, among the main causes of blindness in developed countries. This work presents an exhaustive analysis of intensity and texture-based descriptors for its identification and classification, using a complete set of 510 texture features, three state-of-the-art feature selection strategies, and seven representative classifier strategies ...

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    13. Quantitative Analysis of Anterior Chamber Inflammation Using the Novel CASIA2 Optical Coherence Tomography

      Quantitative Analysis of Anterior Chamber Inflammation Using the Novel CASIA2 Optical Coherence Tomography

      Purpose We evaluated the clinical utility of a novel anterior segment optical coherence tomography (AS-OCT) device, CASIA2, to evaluate parameters indicative of anterior chamber (AC) inflammation severity in uveitis, including AC cell number, flare, and keratic precipitates (KPs). Design Prospective evaluation of a diagnostic device. Methods Uveitis eyes were classified into active and inactive groups. The number of hyper-reflective dots representing AC cells and optical density ratio (aqueous-to-air relative intensity [ARI] index) for flare qualification were calculated from AS-OCT images. Additionally, a program was designed to quantify the posterior corneal surface smoothness (PCSS) of each image for KPs evaluation. The ...

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    14. The evaluation and correlation of subfoveal choroidal thickness and macular hole apical and basal diameters with enhanced depth imaging optical coherence tomography in patients with idiopathic macular hole

      The evaluation and correlation of subfoveal choroidal thickness and macular hole apical and basal diameters with enhanced depth imaging optical coherence tomography in patients with idiopathic macular hole

      Purpose: To investigate the evaluation and correlation between apical and basal hole diameters and subfoveal choroidal thickness (SCT) in patients with idiopathic macular hole (IMH), using enhanced depth imaging optical coherence tomography (OCT). Methods: This cross-sectional study included 30 eyes of 30 patients with IMH and 30 healthy controls eyes. The SCT of subjects were measured using enhanced depth imaging OCT and the results were compared. In the IMH group, the mean horizontal apical and basal diameters of IMH were calculated and the correlation between mean apical and basal diameters and SCT were investigated. All patients with IMH underwent vitreoretinal ...

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    15. In vivo imaging of human cornea with highspeed and high-resolution Fourier-domain full-field optical coherence tomography

      In vivo imaging of human cornea with highspeed and high-resolution Fourier-domain full-field optical coherence tomography

      : Corneal evaluation in ophthalmology necessitates cellular-resolution and fast imaging techniques allowing accurate diagnoses. Currently, the fastest volumetric imaging technique is Fourier-domain full-field optical coherence tomography (FD-FF-OCT) that uses a fast camera and a rapidly tunable laser source. Here, we demonstrate high-resolution, highspeed, non-contact corneal volumetric imaging in vivo with FD-FF-OCT that can acquire a single 3D volume with a voxel rate of 7.8 GHz. The spatial coherence of the laser source was suppressed to prevent it from focusing to a spot on the retina, and therefore, exceeding the maximum permissible exposure (MPE). Inherently volumetric nature of FD-FF-OCT data enabled ...

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    16. Accuracy of swept source optical coherence tomography and ultrasound biomicroscopy for evaluation of posterior lens capsule in traumatic cataract

      Accuracy of swept source optical coherence tomography and ultrasound biomicroscopy for evaluation of posterior lens capsule in traumatic cataract

      Purpose To assess the efficacy of swept source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM) in detecting posterior capsule (PC) defect in patients with traumatic cataract. Design Observational case-series Methods Sixty-seven eyes from 67 patients, without age limitation and with traumatic cataract severe enough to prevent slit lamp evaluation of the PC, included in a simple sequence without randomization. Patients underwent both 50 MHz UBM and SS-OCT evaluation of the PC by different operators. Then, cataract surgery was performed using a single technique. Results Sixty-seven eyes from 67 patients including 60 men and 7 women were studied. The mean ...

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    17. Fast Retinal Segmentation Based on the Wave Algorithm

      Fast Retinal Segmentation Based on the Wave Algorithm

      The retinal layer segmentation technique of optical coherence tomography (OCT) data is essential for the diagnosis of ophthalmic and systemic diseases. To achieve fast and accurate retinal layer segmentation, a new medical image segmentation method (wave algorithm) is proposed based on the mathematical model of the fluid potential energy equation in fluid mechanics. A change in the gray value in the image is converted into a change in the potential energy in the ideal fluid (wave), thereby transforming the image segmentation problem into a problem that solves the potential energy based on the fluid potential energy equation. In the process ...

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    18. Optical coherence tomography angiography findings in axial spondylarthritis

      Optical coherence tomography angiography findings in axial spondylarthritis

      The aim of this study is to evaluate the density of retinal vascular structures and their relationship with disease duration and activity in patients with axial spondylarthritis (axSpA) using optical coherence tomography angiography (OCT-A). In this case–control study, 56 eyes of 29 axSpA patients and 61 eyes of 31 healthy controls (HCs) were evaluated using OCT-A. The capillary plexus density (CPD) of vessels in the parafovea and perifovea regions was evaluated from the superficial capillary plexus (SCP) and deep capillary plexus (DPC) flow areas. The CPD of vessels in the fundus was evaluated from the radial peripapillary capillary (RPC ...

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    19. Foveal Avascular Zone Measurement Via Optical Coherence Tomography Angiography and its Relationship with the Visual Field in Eyes with Open-angle Glaucoma

      Foveal Avascular Zone Measurement Via Optical Coherence Tomography Angiography and its Relationship with the Visual Field in Eyes with Open-angle Glaucoma

      Précis: The foveal avascular zone in optical coherence tomography angiography is significantly correlated with retinal inner layer thickness, Humphrey field analyzer 10-2 sensitivity threshold, and mean deviation value in open-angle glaucoma patients. Purpose: To measure the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) and investigate its relationship with retinal inner layer thickness and visual field defects in eyes with open-angle glaucoma (OAG). Participants and Methods: A total of 52 eyes with OAG from 52 patients. FAZ area was measured using OCTA in angio-macula mode. Thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer plus ...

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    20. Retinal blood flow reduction in normal-tension glaucoma with single-hemifield damage by Doppler optical coherence tomography

      Retinal blood flow reduction in normal-tension glaucoma with single-hemifield damage by Doppler optical coherence tomography

      Aims To evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT. Methods The Doppler OCT was used to measure temporal artery (TA) RBF and temporal vein (TV) RBF. Retinal nerve fibre layer thickness (RNFLT) was measured by spectral-domain OCT. Results Forty-three consecutive eyes of 43 patients with NTG with VF defect confined to a single hemifield and 24 eyes of 24 age-matched healthy subjects were studied. TA and TV RBF and RNFLT were reduced in the damaged hemisphere compared ...

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    21. Reproducibility and agreement of four anterior segment-optical coherence tomography devices for anterior chamber angle measurements

      Reproducibility and agreement of four anterior segment-optical coherence tomography devices for anterior chamber angle measurements

      Purpose To compare the reproducibility and agreement of anterior chamber angle (ACA) parameters and metrics obtained by four different anterior segment-optical coherence tomography (AS-OCT) devices. Methods In this prospective study, 30 eyes from 15 normal subjects underwent anterior segment angle scanning using the Spectralis, Cirrus, and Optovue spectral domain optical coherence tomography (SD-OCT), as well as the Visante time-domain optical coherence tomography (TD-OCT). For each eye, the scan line was performed perpendicularly on the inferior (270°) angle, and the inferior ACA image was acquired 2 times. Inter-instrument and intra-instrument, as well as inter-observer and intra-observer reproducibility of anterior chamber angle ...

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    22. Evaluating Retinal Angiomatous Proliferation With Optical Coherence Tomography Angiography

      Evaluating Retinal Angiomatous Proliferation With Optical Coherence Tomography Angiography

      BACKGROUND AND OBJECTIVE: To report the imaging features of different stages of retinal angiomatous proliferation (RAP) on optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Patients diagnosed with RAP were included in this study. All patients underwent fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and OCTA. The OCTA features were illustrated and compared with FA, ICGA, and OCT. OCTA was performed at baseline and after injection of anti-vascular endothelial growth factor (VEGF). RESULTS: A total of 12 eyes of 12 consecutive patients were included. Patients' ages ranged from 57 to 82 years. In all cases, the ...

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