1. Articles in category: Ophthalmology

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    1. Swept Source Optical Coherence Tomography Angiography for Contact Lens-Related Corneal Vascularization

      Swept Source Optical Coherence Tomography Angiography for Contact Lens-Related Corneal Vascularization

      Purpose . To describe a novel technique of adapting a swept-source optical coherence tomography angiography (OCTA) to image corneal vascularization. Methods . In this pilot cross-sectional study, we obtained 3 × 3 mm scans, where 100,000 A-scans are acquired per second with optical axial resolution of 8  μ m and lateral resolution of 20  μ m. This was performed with manual “XYZ” focus without the anterior segment lens, until the focus of the corneoscleral surface was clearly seen and the vessels of interest were in focus on the corresponding red-free image. En face scans were evaluated based on image quality score and repeatability. Results ...

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    2. Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy

      Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy

      This study aimed to assess the relationship between the rate of nerve fiber loss in non-arteritic anterior ischemic optic neuropathy (NAION) and time delay before therapy. Total 24 patients received the same treatment within or after 2wk (early and late groups). There were significantly lower level of destruction of nerve fibers (P=0.0014) and significantly better visual field sensitivity (P=0.039) in early group. The results indicate that therapy should be started within 2wk. The degree of ischemic damage due to NAION correlates well with retinal nerve fiber layer thickness and the ischemia-induced decrease in visual field sensitivity.

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      Mentions: András Berta
    3. Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris

      Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris

      Despite the prevalence of optical imaging techniques to measure hemodynamics in large retinal vessels, quantitative measurements of retinal capillary and choroidal hemodynamics have traditionally been challenging. Here, a new imaging technique called dynamic contrast optical coherence tomography (DyC-OCT) is applied in the rat eye to study microvascular blood flow in individual retinal and choroidal layers in vivo. DyC-OCT is based on imaging the transit of an intravascular tracer dynamically as it passes through the field-of-view. Hemodynamic parameters can be determined through quantitative analysis of tracer kinetics. In addition to enabling depth-resolved transit time, volume, and flow measurements, the injected tracer ...

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    4. Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography

      Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography

      Purpose : To evaluate the diagnostic ability of layer-by-layer segmented macular ganglion cell complex (GCC) using spectral-domain optical coherence tomography (OCT) for detection of glaucoma and to analyze the topographic patterns of the segmented thicknesses in open-angle glaucoma. Methods : Seventy-seven open-angle glaucoma patients and 59 healthy subjects were enrolled in this cross-sectional study. Spectral-domain OCT with automated segmentation was used to measure the separate thicknesses of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL). We compared the specific diagnostic abilities of the GCC (RNFL+GCL+IPL), ganglion cell–inner plexiform layer (GCIPL: GCL+IPL ...

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    5. Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia

      Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia

      Purpose : To compare the diagnostic powers of parameters of the RTVue and Cirrus-HD optical coherence tomography (OCT) systems in detecting glaucoma in highly myopic eyes. Methods : For this study, 28 glaucoma patients with high myopia (HM-G) and 28 high-myopia controls (HM-C) were enrolled. The circumpapillary retinal nerve fiber layer (cp-RNFL) and ganglion cell complex (GCC) parameters in the RTVue-OCT, and the ganglion cell–inner plexiform layer (GCIPL) and cp-RNFL parameters in the Cirrus HD-OCT, were obtained for each subject. The receiver operating characteristics curve (ROC) was used to assess the diagnostic ability of each parameter, and the areas under the ...

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    6. Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases

      Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases

      Optical coherence tomography (OCT) is a noncontact technology that produces high-resolution cross-sectional images of ocular tissues. Anterior segment OCT (AS-OCT) enables the precise visualization of anterior segment structure; thus, it can be used in various corneal and ocular surface disorders. In this review, the authors will discuss the application of AS-OCT for diagnosis and management of various corneal and ocular surface disorders. Use of AS-OCT for anterior segment surgery and postoperative management will also be discussed. In addition, application of the device for research using human data and animal models will be introduced.

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    7. Fractal Dimensional Analysis of Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy

      Fractal Dimensional Analysis of Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy

      Purpose : We used fractal dimensional analysis to analyze retinal vascular disease burden in eyes with diabetic retinopathy using spectral-domain optical coherence tomography angiography (OCTA). Methods : A retrospective study was performed of 13 eyes with diabetic retinopathy without diabetic macular edema and 56 control eyes. Optical coherence tomography angiography images were acquired using the RTVue XR Avanti. Automated segmentation was obtained through the superficial and deep capillary plexuses for each eye. Grayscale OCTA images were standardized and binarized using ImageJ. Fractal box-counting analyses were performed using Fractalyse. Fractal dimensions (FD) as well as software-generated vascular density analyses of the superficial and ...

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    8. Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Background To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects, and evaluate the consistency between them. Methods Thirty-eight normal subjects (17 men and 21 women) were enrolled in this study. AS-OCT was performed at central cornea and the superior, inferior, nasal and temporal limbus. Then followed by IVCM examination performed at the same location. Agreement was analyzed by mean difference (AS-OCT minus IVCM), 95 % limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland-Altman analysis. Results The average ...

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    9. The effectiveness of optical coherence tomography for evaluating peri-implant tissue: A pilot study

      The effectiveness of optical coherence tomography for evaluating peri-implant tissue: A pilot study

      Purpose Optical coherence tomography (OCT) has been investigated as a novel diagnostic imaging tool. The utilisation of this equipment has been evaluated through several studies in the field of dentistry. The aim of this preliminary study was to determine through basic experiments the effectiveness of OCT in implant dentistry. Materials and Methods To assess detection ability, we captured OCT images of implants in each of the following situations: (1) implants covered with mucosae of various thicknesses that were harvested from the mandibles of pigs; (2) implants installed in the mandibles of pigs; and (3) implants with abutments and crowns fixed ...

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    10. SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT

      SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT

      Purpose: Swept Source Optical Coherence Tomography validates lamina cribrosa anomaly in optic disk pit. Method: Observational case report. Results: A 25-year-old African American male presented with decreased vision in right eye of 4 days duration. Best corrected visual acuity (BCVA) for distance in right eye was 20/200 and in left eye was 20/20. Dilated fundus examination of right eye showed serous macular detachment of entire posterior pole along with an optic pit on temporal margin of optic disk. En-face image of the optic disk on Swept source OCT (SS-OCT) confirmed defect in the lamina cribrosa in the right ...

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    11. Segmentation Based Sparse Reconstruction of Optical Coherence Tomography Images

      Segmentation Based Sparse Reconstruction of Optical Coherence Tomography Images

      We demonstrate the usefulness of utilizing a segmentation step for improving the performance of sparsity based image reconstruction algorithms. In specific, we will focus on retinal optical coherence tomography (OCT) reconstruction and propose a novel segmentation based reconstruction framework with sparse representation, termed segmentation based sparse reconstruction (SSR). The SSR method uses automatically segmented retinal layer information to construct layer-specific structural dictionaries. In addition, the SSR method efficiently exploits patch similarities within each segmented layer to enhance the reconstruction performance. Our experimental results on clinical-grade retinal OCT images demonstrate the effectiveness and efficiency of the proposed SSR method for both ...

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    12. Medical image processing apparatus for examining an eye to determine the stage of glaucoma

      Medical image processing apparatus for examining an eye to determine the stage of glaucoma

      This invention is directed towards a medical image processing apparatus capable of providing effective information on glaucoma by integrating the tomographic image of the retina obtained by an optical coherence tomograph (OCT: Optical Coherence Tomography) and visual function information obtained by a perimeter. The medical image processing apparatus associates visual field measurement results with a fundus camera image (S420). The medical image processing apparatus registers, on the fundus camera image associated with the visual field measurement results, a layer thickness distribution which is obtained from an OCT tomographic image and indicates the thickness of the nerve fiber layer in the ...

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    13. Heidelberg receives FDA clearance to market Spectralis OCT glaucoma module

      Heidelberg receives FDA clearance to market Spectralis OCT glaucoma module

      Heidelberg Engineering received 510(k) clearance from the FDA to market the Spectralis OCT Glaucoma Module Premium Edition, which creates an anatomic map unique to each patient’s eye. The module provides clinicians with objective and automatic measurement parameters for increased diagnostic accuracy, according to a company press release. It utilizes a new technology called Anatomic Positioning System, which uses the center of the fovea and the center of Bruch’s membrane opening to create an anatomic map of the eye. Each scan thereafter is automatically oriented according to each patient’s unique anatomic eye map. In addition, the module ...

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    14. Optical coherence tomography angiography in age-related macular degeneration: persistence of vascular network in quiescent choroidal neovascularization

      Optical coherence tomography angiography in age-related macular degeneration: persistence of vascular network in quiescent choroidal neovascularization

      This study was supported by the Werner H. Spross Foundation (Zurich, Switzerland). The ‘Stiftung wissenschaftliche Forschung, Fonds Ophthalmologie, City Hospital Triemli’ received research grants from Novartis Schweiz AG and Bayer Schweiz AG and payments for invited talks or advisory board participations for M.B and S.M. from Allergan, Novartis, Alimera, Bayer, Roche and Clanotech. None of the authors above has any conflict of interest related to this research. This study was presented as an e-poster (POS- 6771) at the 15th EURETINA Congress in Nice, France (17. – 20.09.2015).

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      Mentions: Stephan Michels
    15. In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to understand anatomic and physiological sources of retinal IOSs and to establish the relationship between IOS distortions and eye diseases. The purpose of this study was designed to demonstrate the feasibility of in vivo IOS imaging of mouse models. A high spatiotemporal resolution spectral domain optical coherence tomography (SD-OCT) was employed for depth-resolved retinal imaging. A custom-designed animal holder equipped with ear bar and bite bar was used to minimize eye movements. Dynamic OCT imaging revealed ...

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      Mentions: Xincheng Yao
    16. Granular Hyperreflective Specks By Spectral Domain Optical Coherence Tomography As Signs Of West Nile Virus Infection: The Stardust Sign

      Granular Hyperreflective Specks By Spectral Domain Optical Coherence Tomography As Signs Of West Nile Virus Infection:  The Stardust Sign

      Purpose: To report the retinal findings and evolution of a visually symptomatic case of West Nile virus meningoencephalitis. Methods: Case report. Main outcome measures include serologic testing for West Nile virus as well as longitudinal funduscopic examination, fluorescein angiography, and spectral domain optical coherence tomography. Results: A 47-year-old diabetic man was referred for ophthalmic evaluation after hospitalization and treatment for West Nile meningoencephalitis. The patient presented with decreased vision and black spots in the right eye. Baseline visual acuity was 20/100 in the right eye and 20/40 in the left. Funduscopic examination and fluorescein angiography revealed multiple outer-retinal ...

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      Mentions: Rui Wang
    17. Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Purpose To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. Methods This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5–18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively. Clinical features and OCT findings, along with their impact on surgical decision-making were analysed. Results Of 27 patients, 10 had unilateral and 17 had bilateral disease. Two patients with mild disease (three eyes) had ...

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    18. Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      The Glaucoma Module Premium Edition for SPECTRALIS provides a comprehensive analysis of the optic nerve head, retinal nerve fiber layer, and ganglion cell layer by precisely matching unique scan patterns to the fine anatomic structures relevant in glaucoma diagnostics. By means of a new proprietary technology called the Anatomic Positioning System, the module creates an anatomic map unique to each patient’s eye using two fixed, structural landmarks: the center of the fovea and the center of Bruch’s membrane opening. All subsequent scan protocols are automatically oriented according to each eye’s unique anatomic map, enabling a precise examination ...

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    19. Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

      Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

      Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from ...

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    20. Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)

      Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)

      This is a 3-year, pharmacologically non-interventional study to evaluate OCT as an outcome measure in patients with relapsing remitting multiple sclerosis (RRMS). Approximately 350 RRMS patients, either untreated or treated with an approved MS disease-modifying therapy and approximately 70 reference subjects without ophthalmologic or neurologic disease are enrolled. No study medications are provided. Patients on disease-modifying therapy are treated according to the local prescribing information. For each MS patient and each reference subject, the study consists of Screening (up to 1 month), Baseline, and a 36-month longitudinal data collection phase. Eligibility will be confirmed during Screening.

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    21. Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects

      Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects

      To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions. The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm 2 and 0.270 ± 0.090 mm 2 , respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the ...

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    22. Axial length measurement failure rates with biometers using swept source optical coherence tomography compared to partial coherence interferometry and optical low-coherence interferometry

      Axial length measurement failure rates with biometers using swept source optical coherence tomography compared to partial coherence interferometry and optical low-coherence interferometry

      Purpose To compare a new swept source optical coherence tomography (SS-OCT) based biometer (OA-2000) with the IOLMaster v5.4 (partial coherence interferometry) and Aladdin (optical low-coherence interferometry) biometers in terms of axial length measurement and failure rate in eyes with cataract. Design Reliability study Methods A total of 377 eyes of 210 patients were scanned with the three biometers in a random order. For each biometer, the number of unobtainable axial length measurements was recorded and grouped as per the type and severity of cataract based on the Lens Opacities Classification System III by the same experienced ophthalmologist. The Bland-Altman ...

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    23. Optical Coherence Tomography (OCT) and Predicting Multiple Sclerosis (MS) Progression (Video)

      Optical Coherence Tomography (OCT) and Predicting Multiple Sclerosis (MS) Progression (Video)

      Retinal thickness is a significant independent predictor of worsening disability in multiple sclerosis (MS) and should be incorporated into clinical trials and treatment decisions, according to a large longitudinal cohort study presented at the American Academy of Neurology (AAN) Annual Meeting Optical coherence tomography (OCT), which is used to measure retinal thickness, can help clinicians predict multiple sclerosis (MS) progression two to five years later, according to an international longitudinal cohort study presented at the 2016 AAN Annual Meeting and published in Lancet Neurology. Overall, the researchers found that thinning in the peripapillary retinal nerve fiber of patients with either ...

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