1. Articles in category: Ophthalmology

    1-24 of 5265 1 2 3 4 ... 218 219 220 »

    1. Optical coherence tomography (OCT) use in non-Alzheimer’s disease (AD) dementias

      Explore j-alz.com Neurology , Ophthalmology
      Optical coherence tomography (OCT) use in non-Alzheimer’s disease (AD) dementias

      We read with great interest the article by Moreno and colleagues [1]. The authors should be congratulated on enlarging our knowledge on retinal nerve fiber layer (RNFL) thickness measurements in Alzheimer’s disease (AD) and other types of dementia. The results of this study show that optical coherence tomography (OCT) seems to be a useful tool for diagnosing dementia syndromes but does not seem to contribute to the differential diagnosis of different types of dementia. Nevertheless, we believe that some supplementary discussion of the problem is needed. Although the authors stated in their article that there were no studies on ...

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    2. Slit-Lamp Optical Coherence Tomography of the Anterior Segment (SL-OCT)

      Explore Home - Springer Ophthalmology
      Slit-Lamp Optical Coherence Tomography of the Anterior Segment (SL-OCT)

      The recent appearance in the market of a new technology applied to the anterior segment has opened the way to coherent light tomographs. The SL-OCT (slit-lamp optical coherence tomography) is a coherent light tomograph adapted to a conventional slit lamp, produced by Heidelberg Engineering, Germany. The Visante is another version of this instrument by Zeiss, with which we have not had any experience yet.

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      Mentions: Heidelberg Engineering Zeiss Visante OCT

    3. Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research

      Phoenix Research Labs, Inc. today announced a partnership with Voxeleron, LLC to lead in the development of optical coherence tomography (OCT) segmentation software. The parties have entered into a strategic partnership to apply Voxeleron segmentation technology to the Phoenix Image-Guided Optical Coherence Tomography (OCT) data. This will allow users to readily analyze retinal layers, precisely measuring changes to thickness and structure over time. “We’re very excited by the opportunity to work with Phoenix. Clearly they have a strong portfolio of technologies optimized for animal eye research, so the addition of image analysis software can only strengthen their customers’ ability ...

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      Mentions: Jonathan D. Oakley Phoenix Research Laboratories Voxeleron

    4. Reproducibility of macular ganglion cell-inner plexiform layer thickness measurement with cirrus HD-OCT in normal, hypertensive and glaucomatous eyes

      Explore BJO Online Ophthalmology
      Reproducibility of macular ganglion cell-inner plexiform layer thickness measurement with cirrus HD-OCT in normal, hypertensive and glaucomatous eyes

      Aim To evaluate the intraobserver and interobserver reproducibility of macular retinal ganglion cell–inner plexiform layer (GC–IPL) thickness measurement by automated detection on Optical Coherence Tomography (OCT) images in normal, hypertensive (ocular hypertensive (OHT)) and glaucomatous eyes. Methods A total of 138 eyes were enrolled in three groups: 69 normal, 35 OHT and 34 primary open-angle glaucoma eyes. All patients underwent a complete ocular examination, 24-2 automated perimetry, biometry and pachymetry. Macular imaging was performed in each eye using the Cirrus HD-OCT 4000 with software V.6.0. (Carl Zeiss Meditec, Dublin, California, USA) three times on the same ...

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      Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT

    6. In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      Explore iovs.org Ophthalmology
      In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      Purpose: Lamina cribrosa (LC) is a leading location of glaucomatous damage. The purpose of this study is to compare LC 3-dimensional microarchitecture between healthy and glaucomatous eyes in-vivo using optical coherence tomography (OCT). Methods: Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47 subjects were scanned in a 3.5x3.5x3.64mm volume (400x400x896 pixels) at the optic nerve head using swept-source OCT. The LC microarchitecture parameters were measured on the visible LC by an automated segmentation algorithm. The LC parameters were compared to diagnosis and visual field mean deviation (MD) using a linear mixed effects model accounting for age ...

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      Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

    7. Subfoveal choroidal thickness measurements with enhanced depth imaging optical coherence tomography in patients with nanophthalmos

      Explore BJO Online Ophthalmology
      Subfoveal choroidal thickness measurements with enhanced depth imaging optical coherence tomography in patients with nanophthalmos

      Purpose To compare subfoveal choroidal thickness (SFCT) between patients with nanophthalmos and age-matched controls. Methods This prospective, cross-sectional and comparative study included 31 eyes from 31 patients with nanophthalmos (study group) and 31 eyes from 31 healthy subjects (control group). SFCT and central macular thickness (CMT) were measured with spectral domain optical coherence tomography. All participants underwent a standardised ocular examination including best corrected visual acuity (BCVA), central corneal thickness (CCT), anterior chamber depth (ACD) and refractive error (RE) measurements. Results Mean SFCT in the nanophthalmic eyes and in the control eyes were 551.3±87 µm and 330.5 ...

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    8. Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Explore Optical Coherence Tomography News Ophthalmology , Jobs & Studentships
      Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis. One position will be filled by someone with background in vision science while the other will be for a person with experience in a high-resolution imaging modality such as OCT, adaptive optics or scanning laser ophthalmoscope. Strong skills in programming or image processing would be an asset. The positions will be open until filled. Salary will be based on experience and salary scales of the UC. The University of California is committed to diversity. Minorities, women, veterans and persons ...

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      Mentions: John S. Werner UC Davis

    9. Ultra-widefield imaging may improve ability to diagnose, monitor, treat

      Explore Healio.com Ophthalmology
      Ultra-widefield imaging may improve ability to diagnose, monitor, treat

      Ultra-widefield retinal imaging is a viable option that may improve the efficiency of diagnostics for diabetic retinopathy and diabetic macular edema, according to one specialist. Standard methods for assessment and follow-up of DR and DME have included fluorescein angiography, fundus photography and optical coherence tomography. However, novel ultra-widefield (UWF) scanning laser technology ( Optos ) allows wide-angle visualization that includes peripheral areas of the retina ...

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      Mentions: Optos

    10. Epiretinal Membranes in Patients with Uveitis: Morphological and Functional Analysis with Spectral Domain Optical Coherence Tomography

      Explore Hindawi Publishing Corporation Ophthalmology
      Epiretinal Membranes in Patients with Uveitis: Morphological and Functional Analysis with Spectral Domain Optical Coherence Tomography

      Purpose . To correlate the uveitic epiretinal membrane (ERM) features using spectral-domain optical coherence tomography (SD-OCT) with visual acuity (VA). Methods . Forty-one eyes of 32 patients were included in this retrospective study. SD-OCT was performed in all patients and data were collected at the time of ERM diagnosis and at the final visit. Both best corrected visual acuity (BCVA) and ERM thickness were correlated with the morphological and clinical features. Results . Final BCVA was positively correlated with male sex and the focal pattern of ERM attachment and negatively correlated with IS/OS photoreceptor junction disruption . BVCA change showed a positive correlation ...

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      Mentions: Heidelberg Engineering Heidelberg Spectralis Sapienza University of Rome

    11. Can optical coherence tomography replace fluorescein angiography in detection of ischemic diabetic maculopathy?

      Explore Home - Springer Ophthalmology
      Can optical coherence tomography replace fluorescein angiography in detection of ischemic diabetic maculopathy?

      Background We studied the association between (1) the retinal thickness, volume and structure assessed by optical coherence tomography (OCT), and (2) vascular changes around the fovea in FA to define the role of these methods in the detection of ischemic diabetic maculopathy. Methods This retrospective observational study included 51 eyes of 51 patients with severe non-proliferative and proliferative diabetic retinopathy, considering that they present advanced ischemic retinal changes. Based on the clinical examination and presence of leakage on FA, patients with clinically significant macular edema were excluded. On FA, foveal avascular zone (FAZ) corresponds to capillary loss and reflects ischemic ...

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    12. Feature Of The Week 12/1/13: Simultaneous Dual Wavelength Eye-Tracked Ultrahigh Resolution Retinal and Choroidal OCT

      Explore Optical Coherence Tomography News Ophthalmology
      Feature Of The Week 12/1/13: Simultaneous Dual Wavelength Eye-Tracked Ultrahigh Resolution Retinal and Choroidal OCT

      An eye-tracked high resolution OCT device is presented for clinical multimodal imaging of the retina and the deep choroid, based on the platform of a commercial Heidelberg-Engineering SPECTRALIS® OCT device. The system is aimed to drive the development of novel therapeutic approaches for better eye care. The dual spectrometer based frequency domain OCT with built-in confocal scanning laser ophthalmoscope (SLO) operating at 735 nm, corrects for eye-motion in real time and enables arbitrary selection of the location of interest as well as automatic re-positioning of successive measurements or in follow up studies. Common clinical ophthalmic OCT devices perform raster scanning ...

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      Mentions: Wolfgang Drexler Heidelberg Engineering Exalos

    13. Diagnostic Techniques: Optical Coherence Tomography (Book Chapter)

      Explore Home - Springer Ophthalmology , Textbooks
      Diagnostic Techniques: Optical Coherence Tomography (Book Chapter)

      Optical coherence tomography (OCT) is a powerful imaging technique that provides cross-sectional imaging of the internal microstructures of biological tissues. Among several implementations of OCT, spectral-domain OCT (SD-OCT) provides high-resolution, high-sensitivity, and high-speed imaging. Such implementations enable visualization of the microstructures of the human eye by noninvasive and noncontact measurement. High sensitivity of OCT detection enables imaging of structures with very low optical scattering, such as the retina. The high axial and lateral resolution enables the precise morphological investigation of various pathological conditions. Recently, hardware and software upgrades have improved the ability to better evaluate intraocular tumors.

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    14. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes

      Explore BJO Online Ophthalmology
      Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes

      Objective To compare spectral-domain optic coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) in the study of choroidal thickness (CT) in healthy eyes. Methods Prospective, cross-sectional, single-centre study. 82 healthy eyes of 46 patients were included. In a single session, Topcon 3D-2000 SD-OCT and 1050 nm SS-OCT prototype devices were used to perform OCT scans using a single line protocol. Two masked investigators independently, manually determined 13 CT measurements consisting of one subfoveal (SFCT), and six measurements on either side of the fovea (nasal and temporal) taken every 500 microns apart. The mean CT (MCT) was the mean average of these ...

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      Mentions: Topcon Medical Systems Topcon 3D OCT-2000

    15. Optical Coherence Tomography and Visual Field Findings in Patients With Friedreich Ataxia

      Explore LWW Online Neurology , Ophthalmology
      Optical Coherence Tomography and Visual Field Findings in Patients With Friedreich Ataxia

      BACKGROUND:: To investigate the optical coherence tomography (OCT) and visual field findings in Friedreich ataxia (FRDA). METHODS:: Ten eyes of 10 patients with genetically confirmed FRDA were included in this study. Twenty-two eyes of 22 age- and sex-matched volunteers served as controls. All eyes were examined with spectral domain OCT (Retinascan Advanced RS-3000; NIDEK) and Humphrey Field Analyzer (HFA II 750; Zeiss-Humphrey Systems). RESULTS:: OCT measurements of the average peripapillary retinal nerve fiber layer (RNFL) thickness, average peripapillary retinal thickness (RT), and foveal RT showed a statistically significant reduction in patients with FRDA (P < 0.0001). There was no statistically ...

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      Mentions: Nidek Nidek RS-3000

    16. Optical coherence tomography 2014

      Explore Healio.com Ophthalmology
      Optical coherence tomography 2014

      Optical coherence tomography (OCT) is now widely recognized as the most important retinal imaging technique, replacing angiographic techniques as first-line imaging tools. This has largely been driven by widespread application of retinal pharmacotherapy. As a clinical decision-making tool in that setting, OCT has unparalleled value in delivering important information in a matter of seconds. OCT has dramatically improved the productivity of retinal specialists — ie, the number of patients who can be evaluated in a given clinical session. This special issue on OCT highlights its value as a quantitative tool in assessing retinal anatomy in both health and disease, its power ...

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      Mentions: Carmen A. Puliafito University of Southern California

    17. Enhanced Depth Imaging OCT and Indocyanine Green Angiography Changes in Acute Macular Neuroretinopathy

      Explore Healio.com Ophthalmology
      Enhanced Depth Imaging OCT and Indocyanine Green Angiography Changes in Acute Macular Neuroretinopathy

      The authors describe indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a 46-year-old male patient with acute macular neuroretinopathy (AMN). The chief complaint was decreasing visual acuity and metamorphopsia in both eyes of 1-month duration. Visual field assessment, fluorescein angiography, OCT, ICGA, and EDI-OCT were performed initially and at 3 months. ICGA showed choroidal vascular hyperpermeability and punctuate choroidal hyperfluorescent spots, especially in the left eye. EDI-OCT showed increased choroidal macular thickness, with inner and outer retinal layers affected. EDI-OCT and ICGA reveal that both the choroid and retina can be affected in AMN; however ...

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      Mentions: University of Arizona Jerry A. Shields Lawrence A. Yannuzzi

    18. Enhanced Visualization of the Choroido-Scleral Interface Using Swept-Source OCT

      Explore Healio.com Ophthalmology
      Enhanced Visualization of the Choroido-Scleral Interface Using Swept-Source OCT

      An accurate analysis of the thickness and volume of choroid using optical coherence tomography (OCT) requires precise visualization of the choroido-scleral interface. Results of studies that use spectral-domain OCT (SD-OCT) to look at the percent visualization of the choroido-scleral interface for accurate analysis of choroidal thickness show varying success rates. This study assessed the visualization of choroido-scleral interface in 19 healthy participants (19 eyes) prospectively recruited for consecutive high-definition raster scanning with an SD-OCT system with and without enhanced depth imaging (EDI) and a prototype long-wavelength swept-source OCT (SS-OCT) system. Choroido-scleral interface was visualized in all eyes imaged on SS-OCT ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Optovue

    19. Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography

      Explore PLoS ONE Ophthalmology
      Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography

      Purpose Thickness changes of corneal sub-layers after phacoemulsification were investigated by spectral domain ultra-high resolution optical coherence tomography (UHR-OCT). Methods The corneas (n = 26) of 26 age-related cataract surgery patients were studied. UHR-OCT was used to evaluate the thickness of Descemet’s Endothelium Complex (DEC), stroma, Bowman’s layer, epithelium, and full cornea at the center (CCT) before, one day after, and one week after surgery. Non-contact specular microscopy measured CCT, endothelial cell density, and morphology. Results The DEC, stroma, Bowman’s layer, and epithelium were visualized by UHR-OCT. Before surgery, the DEC in all cases appeared as a translucent ...

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      Mentions: Jianhua Wang Wenzhou Medical College University of Miami

    20. Parametric Model for the 3D Reconstruction of Individual Fovea Shape from OCT Data

      Explore ScienceDirect Ophthalmology
      Parametric Model for the 3D Reconstruction of Individual Fovea Shape from OCT Data

      As revealed by optical coherence tomography (OCT), the shape of the fovea may vary greatly among individuals. However, none of the hitherto available mathematical descriptions comprehensively reproduces all individual characteristics such as foveal depth, slope, naso-temporal asymmetry, and others. Here, a novel mathematical approach is presented to obtain a very accurate model of the complete 3D foveal surface of an individual, by utilizing recent developments in OCT. For this purpose, a new formula was developed serving as a simple but very flexible way to represent a given fovea. An extensive description of the used model parameters, as well as, of ...

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      Mentions: University of Leipzig

    21. Combining Spectral Domain Optical Coherence Tomography Structural Parameters for the Diagnosis of Glaucoma with Early Visual Field Loss

      Explore iovs.org Ophthalmology
      Combining Spectral Domain Optical Coherence Tomography Structural Parameters for the Diagnosis of Glaucoma with Early Visual Field Loss

      PURPOSE. To create a multivariable predictive model for glaucoma with early visual field loss using a combination of spectral domain optical coherence tomography (OCT) parameters, and to compare the results with single variable models. METHODS. Two hundred and fifty-three subjects (149 normal controls and 104 with early glaucoma) underwent optic disc and macular scanning using spectral domain OCT in one randomly selected eye per subject. Sixteen parameters (rim area, cup-to-disc area ratio, vertical cup-to-disc diameter ratio, average and quadrant RNFL thicknesses, average, minimum, and sectoral GCIPL thicknesses) were collected and submitted to an exploratory factor analysis (EFA) followed by logistic ...

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      Mentions: University of North Carolina Donald L. Budenz Jean C. Mwanza

    22. Optical coherence tomography as a diagnostic tool for retinal pathologies in avian ophthalmology

      Explore iovs.org Ophthalmology
      Optical coherence tomography as a diagnostic tool for retinal pathologies in avian ophthalmology

      Purpose:Optical coherence tomography (OCT) is an established diagnostic tool for retinal pathologies in human eyes and was adapted to small animal models. However, there are only few attempts to use OCT for examinations of avian eyes and little is known about structural details of healthy or pathologically affected retinas in living birds. Methods:We used SD-OCT (High Resolution Spectral Domain OCT) to investigate eyes of various avian species including birds of prey. The birds were anesthetized by Isofluran application during OCT examination. Eyes of a common buzzard (Buteo buteo) could be used for a comparative analysis of OCT images ...

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      Mentions: University of Leipzig

    23. En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy

      Explore Ophthalmology Ophthalmology
      En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy

      Objective To characterize en face features of the retinal pigment epithelium (RPE) and choroid in eyes with chronic central serous chorioretinopathy (CSCR) using a high-speed, enhanced-depth swept-source optical coherence tomography (SS-OCT) prototype. Design Consecutive patients with chronic CSCR were prospectively examined with SS-OCT. Participants Fifteen eyes of 13 patients. Methods Three-dimensional 6×6 mm macular cube raster scans were obtained with SS-OCT operating at 1050 nm wavelength and 100 000 A-lines/sec with 6 μm axial resolution. Segmentation of the RPE generated a reference surface; en face SS-OCT images of the RPE and choroid were extracted at varying depths every ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker

    24. Analysis of Peripapillary Atrophy According to the Optic Disc Shape Using Spectral Domain OCT

      Explore KoreaMed Synapse Ophthalmology
      Analysis of Peripapillary Atrophy According to the Optic Disc Shape Using Spectral Domain OCT

      Purpose To analyze the structural changes in the β-zone of peripapillary atrophy (PPA-β) using cross-sectional image of the optic disc head from spectral-domain optical coherence tomography (SD-OCT) according to the optic disc shape. Methods One hundred thirty-seven eyes in 137 patients with glaucoma having PPA-β and 31 normal eyes (control group) were evaluated retrospectively. Cross-sectional images of the optic disc were taken using the Cirrus HD-OCT. We classified optic disc patterns into normal, focal, myopic, generalized enlargement and senile sclerotic appearance types and analyzed the shape of Bruch's membrane (BM), composition of retinal layer and retinal slope according to ...

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      Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT
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