Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss
  
  Explore Nature Publishing Group Sep 18 2019 Ophthalmology
  
  Aims To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss. Methods Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF ...
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  Mentions: University of São Paulo
2. Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance
  
  Explore Optical Coherence Tomography News Sep 17 2019 Ophthalmology , Other Business News
  
  Expanding the company's lineup of eye-care product offerings, Canon U.S.A. , Inc., a leader in digital imaging solutions, is pleased to announce the new intuitive, user-friendly Xephilio OCT-A1 Optical Coherence Tomography device from Canon Inc. This device features automated acquisition functionality, which makes it easy to use, allowing healthcare professionals to obtain high-quality reproducible scans and images. The Xephilio OCT-A1 Optical Coherence Tomography device has received FDA 510(k) clearance for sale in the United States of America 1. The Xephilio OCT-A1 Optical Coherence Tomography device, together with the required RX Capture software, computer and LCD monitor (collectively ...
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  Mentions: Canon Medical Systems
3. Changes in Amblyopia Using Optical Coherence Tomography
  
  Explore Home - ClinicalTrials.gov Sep 17 2019 Ophthalmology , Clinical Trials
  
  There have been multiple trials to investigate the morphological changes in the macula and retinal nerve fiber layer of amblyopic eyes, due to the different published results and the lack of evident association between these changes and the patients' parameters. So, we perform this study to compare the variations in macular parameters (central thickness, average thickness, macular volume) and peripapillary thickness in different cases of amblyopic eyes versus the normal fellow eyes using spectral-domain optical coherence tomography . In addition, to estimate the relationship of optical coherence tomography variations with different defined patients' parameters (age, sex, best corrected visual acuity, spherical ...
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4. Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes
  
  Explore Wiley Online Library Sep 17 2019 Ophthalmology
  
  Purpose To determine the long‐term repeatability of optical coherence tomography angiography (OCTA) parameters in normal eyes. Methods We prospectively enrolled 104 normal eyes. Participants were divided into three groups based on differences in the signal strength (SS) of OCTA scans obtained at two visits at least 6 months apart: group 1, SS difference = 2; group 2, 1; group 3, 0. We measured a foveal centred scan area of 3 × 3 mm pattern. All measurements were performed twice at 5‐min intervals at the initial visit. The second measurements were performed at least 6 months later. Results In short‐term ...
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  Mentions: Chungnam National University Hospital
5. Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease
  
  Explore TVST Journal Sep 17 2019 Ophthalmology
  
  Purpose : This study assessed agreement between an automated spectral-domain optical coherence tomography (SD-OCT) retinal segmentation software and manually corrected segmentation to validate its use in a prospective clinical study of neurodegenerative diseases (NDD). Methods : The sample comprised 30 subjects with NDD, including vascular cognitive impairment, frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. Macular SD-OCT scans were acquired and segmented using Heidelberg Spectralis. For the central foveal B scan of each eye, eight segmentation lines were examined to determine the proportion of each line that the software erroneously delineated. Errors in four lines were manually corrected in all B ...
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  Mentions: University of Toronto University of Waterloo
6. Detecting and measuring areas of choriocapillaris low perfusion in intermediate, non-neovascular age-related macular degeneration
  
  Explore SPIE Digital Library Sep 17 2019 Ophthalmology
  
  Age-related macular degeneration (AMD) is a vision-threatening disease that affects the outer retina and choroid of elderly adults. Because photoreceptors are found in the outer retina and rely primarily on the trophic support of the underlying choriocapillaris, imaging of flow or lack thereof in choriocapillaris by optical coherence tomography angiography (OCTA) has great clinical potential in AMD assessment. We introduce a metric using OCTA, named “focal perfusion loss” (FPL) to describe the effects of age and non-neovascular AMD on choriocapillaris flow. Because OCTA imaging of choriocapillaris is vulnerable to artifacts—namely motion, projections, segmentation errors, and shadows—they are removed ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
7. Disproportion of lamellar capillary non-perfusion in proliferative diabetic retinopathy on optical coherence tomography angiography
  
  Explore BJO Online Sep 17 2019 Ophthalmology
  
  Purpose To characterise the non-perfused areas (NPAs) in the superficial and deep capillary layers (sNPAs and dNPAs, respectively) in the posterior pole in proliferative diabetic retinopathy (PDR) on wide-field optical coherence tomography angiography (OCTA) images. Methods We retrospectively reviewed 104 eyes of 70 patients with PDR from whom wide-field swept source OCTA images were acquired. sNPAs and dNPAs were manually measured in each quadrant of the inner (1–3 mm diameter), intermediate (3–6 mm), and outer (6–10 mm) rings centred on the fovea. Two qualitative findings, that is, segmented NPAs and periarteriolar NPAs , were also compared. Results The ...
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  Mentions: Akitaka Tsujikawa Kyoto University Graduate School of Medicine
8. Automatic choroidal segmentation in OCT images using supervised deep learning methods
  
  Explore Nature Publishing Group Sep 16 2019 Ophthalmology
  
  The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture highly detailed cross-sectional images of the choroid yet only a very limited number of commercial OCT instruments provide methods for automatic segmentation of choroidal tissue. Manual annotation of the choroidal boundaries is often performed but this is impractical due to the lengthy time taken to analyse large volumes of images. Therefore, there is a pressing need for reliable and accurate methods to automatically segment choroidal tissue boundaries in ...
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  Mentions: University of Queensland University of Western Australia Fred K. Chen
9. Optoretinography: optical measurements of human cone and rod photoreceptor responses to light
  
  Explore bioRxiv.org Sep 15 2019 Ophthalmology
  
  Rods contribute crucially to human vision and their dysfunction precedes cones' in several retinal diseases. Here we describe light-evoked, functional responses of human rods and cones, measured noninvasively using adaptive optics optical coherence tomography.
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  Mentions: John S. Werner UC Davis Robert J. Zawadzki
10. Pattern electroretinogram changes in patients with primary open-angle glaucoma in correlation with visual field and optical coherence tomography changes
  
  Explore SAGE Journals Sep 14 2019 Ophthalmology
  
  Purpose: To study the pattern electroretinogram changes in primary open-angle glaucoma patients in correlation with visual field changes and optical coherence tomography measurements of retinal nerve fiber layer thickness in the peripapillary region in an attempt to evaluate the clinical value of pattern electroretinogram as an objective test of functional deficit in glaucoma. Patients and Methods: The study included 81 eyes of 81 participants: 50 primary open-angle glaucoma patients, 16 primary open-angle glaucoma suspects, and 15 controls. All subjects underwent visual field testing using 24-2 Humphrey standard automated perimetry, peripapillary retinal nerve fiber layer average thickness using the 3.4-mm ...
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11. Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography
  
  Explore ScienceDirect Sep 14 2019 Ophthalmology
  
  Purpose To present the routine use of optical coherence tomography (OCT) and OCT angiography (OCTA) for the objective diagnosis and monitoring of proliferative diabetic retinopathy (PDR). Design Retrospective observational case series. Subjects Patients with diabetic retinopathy imaged using a standardized PDR-protocol Methods Patients routinely imaged with a standardized PDR-protocol between March 2017 and January 2019 were included. This included a 12x9 mm structural OCT volume centered on the macula and a 6x6 mm OCTA scan centered on the optic nerve head obtained using a Topcon swept-source system (DRI OCT-1 Triton, Topcon, Tokyo, Japan). Ultra-widefield fluorescein angiography (FA) was also performed ...
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  Mentions: University College London Praveen J. Patel Pearse A. Keane
12. Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status
  
  Explore Healio.com Sep 14 2019 Ophthalmology
  
  $Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status$
  PURPOSE: To assess the repeatability of epithelial, stromal, and total corneal thickness measurements with spectral-domain optical coherence tomography (SD-OCT; RTVue-XR; Optovue, Inc., Fremont, CA) in patients with myopia, keratoconus, and corneas after transepithelial photorefractive keratectomy (PRK), small incision lenticule extraction (SMILE), and femtosecond laser–assisted in situ keratomileusis (FS-LASIK). METHODS: A total of 352 eyes of 352 patients (75 myopic, 68 post-transepithelial PRK, 61 post-SMILE, 75 post-FS-LASIK, 20 mild keratoconus, and 53 advanced keratoconus eyes) were included. The epithelial, stromal, and total corneal thickness were recorded from the pachymetric map in the following four zones: (1) central 2-mm region, (2 ...
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  Mentions: Optovue
13. Optical coherence tomography diagnostic signs in posterior uveitis
  
  Explore ScienceDirect Sep 14 2019 Ophthalmology
  
  A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into “personalized” medicine. Many new diagnostic signs are being developed that involve imaging technology. Optical coherence tomography is an imaging technique that provides in vivo quasi-histological images of the ocular tissues and as such it's able to capture the structural and functional modifications that accompany ...
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  Mentions: Case Western Reserve University Northwestern University University of Sydney
14. Optical coherence tomography en face analysis of the posterior vitreous reveal topographic relationships between premacular bursa, prevascular fissures and cisterns
  
  Explore ScienceDirect Sep 14 2019 Ophthalmology
  
  Purpose To characterize the topographic relationships among vitreous structures including the premacular bursa, prevascular vitreous fissures, cisterns and lacunae in healthy subjects using en face and cross-sectional swept-source optical coherence tomography (SS-OCT). Design Prospective comparative study. Subjects Sixty eyes of 60 healthy subjects (age range = 4 – 35 years). Eyes of individuals younger than 20 years (n= 29) were compared with eyes of individuals aged 20 years or older (n=31). Testing Twelve x 12-mm SS-OCT volume scans comprised of 1024 x 1024 A-scans centered at the fovea were acquired from each study eye. Main Outcome Measures En face and cross-sectional ...
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  Mentions: LuEsther T. Mertz Retinal Research Center University of Zurich K. Bailey Freund
15. Spatial analysis of thickness changes in ten retinal layers of Alzheimer’s disease patients based on optical coherence tomography
  
  Explore Nature Publishing Group Sep 14 2019 Neurology , Ophthalmology
  
  The retina is an attractive source of biomarkers since it shares many features with the brain. Thickness differences in 10 retinal layers between 19 patients with mild Alzheimer’s disease (AD) and a control group of 24 volunteers were investigated. Retinal layers were automatically segmented and their thickness at each scanned point was measured, corrected for tilt and spatially normalized. When the mean thickness of entire layers was compared between patients and controls, only the outer segment layer of patients showed statistically significant thinning. However, when the layers were compared point-by point, patients showed statistically significant thinning in irregular regions ...
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  Mentions: San Carlos University Hospital
16. Detection of reduced retinal vessel density in eyes with geographic atrophy secondary to age-related macular degeneration using projection-resolved optical coherence tomography angiography
  
  Explore American Journal of Ophthalmology Sep 14 2019 Ophthalmology
  
  Purpose To compare retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to age-matched healthy eyes using projection-resolved optical coherence tomography angiography (PR-OCTA). Design Prospective cross-sectional study. Methods Study participants underwent macular 3×3-mm OCTA scans with spectral domain OCTA. Reflectance-compensated retinal vessel densities were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Quantitative analysis using normalized deviation compared the retinal vessel density in GA regions, 500 μm GA rim regions, and non-GA regions to similar macular locations in control eyes. Results Ten eyes with GA ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
17. Researchers have identified areas of the retina that change in mild Alzheimer's disease
  
  Explore Medical Xpress Sep 13 2019 Neurology , Ophthalmology
  
  Researchers at the Complutense University of Madrid (UCM) have identified changes in retinal layer thickness, inflammation or thinning in patients with mild Alzheimer's disease, confirming that the retina is one of the most important biomarkers for early diagnosis of the disease. For the first time, researchers have determined the shape and size of the areas that present significant thinning in each retinal layer, which tend to occur in the same locations.
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18. Optical coherence tomography and multiple sclerosis: Update on clinical application and role in clinical trials
  
  Explore SAGE Journals Sep 12 2019 Neurology , Ophthalmology
  
  Optical coherence tomography (OCT) has emerged as a fast, non-invasive, inexpensive, high-resolution imaging technique in multiple sclerosis (MS). Retinal layer quantification by OCT facilitates a ‘window’ into not only local retinal pathology but also global neurodegenerative processes, recognised to be the principal substrates of disability accumulation in MS. While OCT measures in MS have been demonstrated to reflect visual function, inflammatory activity outside of the visual pathways, disability measures including the prediction of disability progression, whole brain atrophy, and the differential neuroprotective effects of disease-modifying therapies, debate continues regarding the clinical utility of OCT in everyday practice. This review presents ...
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  Mentions: Johns Hopkins University Cleveland Clinic
19. Postdoc Position at the University of Southern California
  
  Explore Optical Coherence Tomography News Sep 12 2019 Ophthalmology , Jobs & Studentships
  
  A postdoctoral researcher position is available immediately in the Department of Otolaryngology at the University of Southern California. The principal project will be to develop Optical Coherence Tomography (OCT) systems for functional and morphological imaging in the human ear. The utilization of OCT for imaging in the human ear is a growing field with a range of applications from basic science research to the diagnosis and monitoring of disease. The postdoctoral researcher will work within the lab of Brian Applegate, PhD , but in close collaboration with the group of John Oghalai, MD. They occupy adjacent lab space and are part ...
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  Mentions: University of Southern California Brian E. Applegate John S. Oghalai
20. Specsavers Installs the 350th Topcon Maestro Fully Automated OCT
  
  Explore Optical Coherence Tomography News Sep 12 2019 Ophthalmology , Other Business News
  
  Leading OCT Technology Enables Specsavers Optometrists to Provide Unsurpassed Eye Care to Their Patients Topcon Medical Systems (TMS), of Oakland, NJ, USA, a leading provider of diagnostic equipment and software solutions for the eye care industry, and Specsavers, Australia’s #1 optometry practice network, are pleased to announce the installation of the 350th Topcon Maestro Fully Automated OCT/Fundus Camera into Specsavers retail locations across Australia and New Zealand. After careful consideration of several devices, Specsavers chose to incorporate the Maestro OCT into all its locations based on its ease of use, space-saving design, enhanced diagnostic tools and clinical accuracy ...
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  Mentions: Topcon Medical Systems Specsavers
21. Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes
  
  Explore Medical Journals Publisher Sep 12 2019 Ophthalmology
  
  Purpose: To investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of the peripapillary retina and optic nerve head (ONH) in normal eyes and eyes with primary open-angle glaucoma (POAG). Patients and methods: One eye from each of 46 normal subjects and mild and moderate/advanced POAG patients were included. ONH blood flow acquired by LSFG, circumpapillary vessel density (cpVD, a 250 μm-wide elliptical annulus around the optic disc), and intra-papillary vessel density (ipVD, a 1.5×1.5 mm scan field) acquired by OCTA were measured. Their values were compared among normal controls ...
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22. Femtosecond Laser With Integrated Anterior Segment Optical Coherence Tomography As A Tool To Detect PRE-EXISTING Posterior Capsular Dehiscence And Increase Safety In Posterior Polar Cataracts
  
  Explore Journal of Cataract & Refractive Surgery Sep 12 2019 Ophthalmology
  
  Purpose To determine the efficacy of femtosecond integrated anterior segment optical coherence tomography (ASOCT) for the detection of posterior capsular dehiscence in posterior polar cataracts (PPC). To evaluate the safety of phacoemulsification in these eyes undergoing Femtosecond Laser Assisted Cataract Surgery (FLACS). Setting Centre For Sight Group of Eye Hospitals, a chain of tertiary eye care hospitals in India. Design Prospective, interventional case series Methods The study included eyes with PPC undergoing FLACS using the Catalys femtosecond platform (Optimedica, CA, USA). Real time OCT guidance was utilized to image the posterior capsule (PC), which was then classified as “intact” or ...
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23. ZEISS to showcase advancements in digital and surgical technology at ESCRS 2019
  
  Explore PR Newswire Sep 12 2019 Ophthalmology , Other Business News
  
  During the 2019 European Society of Cataract and Refractive Surgery (ESCRS) Annual Meeting in Paris , ZEISS Medical Technology Segment will present new technologies advancing the digitalization of eye care and high-resolution imaging, helping doctors maximize clinical efficiency and performance. ZEISS ARTEVO 800 ZEISS CIRRUS 6000 including application ZEISS SL 800
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  Mentions: Carl Zeiss Meditec
24. Reliability of Intra-Retinal Layer Thickness Estimates
  
  Explore Journals | PLOS Sep 11 2019 Ophthalmology
  
  Purpose Measurement of intra-retinal layer thickness using optical coherence tomography (OCT) has become increasingly prominent in multiple sclerosis (MS) research. Nevertheless, the approaches used for determining the mean layer thicknesses vary greatly. Insufficient data exist on the reliability of different thickness estimates, which is crucial for their application in clinical studies. This study addresses this lack by evaluating the repeatability of different thickness estimates. Methods Studies that used intra-retinal layer segmentation of macular OCT scans in patients with MS were retrieved from PubMed. To investigate the repeatability of previously applied layer estimation approaches, we generated datasets of repeating measurements of ...
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  Mentions: Friedemann Paul Timm Oberwahrenbrock
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