1. Articles in category: Ophthalmology

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    1. Choroidal Thickness Analysis in Patients with Usher Syndrome Type 2 Using EDI OCT

      Choroidal Thickness Analysis in Patients with Usher Syndrome Type 2 Using EDI OCT

      To portray Usher Syndrome type 2, analyzing choroidal thickness and comparing data reported in published literature on RP and healthy subjects. Methods . 20 eyes of 10 patients with clinical signs and genetic diagnosis of Usher Syndrome type 2. Each patient underwent a complete ophthalmologic examination including Best Corrected Visual Acuity (BCVA), intraocular pressure (IOP), axial length (AL), automated visual field (VF), and EDI OCT. Both retinal and choroidal measures were measured. Statistical analysis was performed to correlate choroidal thickness with age, BCVA, IOP, AL, VF, and RT. Comparison with data about healthy people and nonsyndromic RP patients was performed. Results ...

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    2. Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials

      Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials

      Background . The lack of segmentation algorithms operative across optical coherence tomography (OCT) platforms hinders utility of retinal layer measures in MS trials. Objective . To determine cross-sectional and longitudinal agreement of retinal layer thicknesses derived from an open-source, fully-automated, segmentation algorithm, applied to two spectral-domain OCT devices. Methods . Cirrus HD-OCT and Spectralis OCT macular scans from 68 MS patients and 22 healthy controls were segmented. A longitudinal cohort comprising 51 subjects (mean follow-up: 1.4 ± 0.9 years) was also examined. Bland-Altman analyses and interscanner agreement indices were utilized to assess agreement between scanners. Results . Low mean differences (−2.16 to ...

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    3. Comparing Structure-Function Correlations in Superior Segmental Optic Nerve Hypoplasia and Juvenile Open Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

      Comparing Structure-Function Correlations in Superior Segmental Optic Nerve Hypoplasia and Juvenile Open Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

      Superior segmental optic nerve hypoplasia (SSOH) is a congenital anomaly of the optic nerve that is commonly misdiagnosed as normal tension glaucoma (NTG) and/or juvenile open angle glaucoma (JOAG). We demonstrate the utility of SD-OCT in assessing the structure-function correlation when differentiating between SSOH and JOAG.

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    4. The Presence of Intra- or Subretinal Fluid during the Loading Phase in the Treatment of Exudative Age-Related Macular Degeneration with Intravitreal Ranibizumab Assessed by Optical Coherence Tomography

      The Presence of Intra- or Subretinal Fluid during the Loading Phase in the Treatment of Exudative Age-Related Macular Degeneration with Intravitreal Ranibizumab Assessed by Optical Coherence Tomography

      Purpose: To assess intra- and subretinal fluid during the loading phase with intravitreal ranibizumab in exudative age-related macular degeneration and to quantify the accuracy of crosshair scan spectral-domain optical coherence tomography with regard to retinal fluid. Methods: This is a retrospective study of 31 treatment-naive patients who received 3 monthly intravitreal ranibizumab injections. Visual acuity and the presence of retinal fluid were assessed at each visit using volume and crosshair scan protocols. Results: Visual acuity improved and central retinal thickness decreased significantly during the loading phase. However, retinal fluid persisted in two thirds of the patients. The accuracy of the ...

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    5. Doppler Optical Coherence Tomography Imaging of Feeder Vessels in Exudative Macular Disease

      Doppler Optical Coherence Tomography Imaging of Feeder Vessels in Exudative Macular Disease

      We evaluated the three-dimensional vascular architecture of feeder vessels in exudative macular disease. A case of polypoidal choroidal vasculopathy with choroidal neovascularization was examined with Doppler optical coherence tomography (OCT), and the three-dimensional architecture of the feeder vessels could be clearly visualized in the Doppler OCT angiography image, showing the site of growth of the feeder vessels passing through Bruch’s membrane. Together, the results demonstrated in this case report that Doppler OCT was useful for the noninvasive assessment of feeder vessels in exudative macular disease.

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    6. En Face Imaging of Posterior Precortical Vitreous Pockets Using Swept-Source Optical Coherence Tomography

      En Face Imaging of Posterior Precortical Vitreous Pockets Using Swept-Source Optical Coherence Tomography

      PURPOSE. To obtain sequential flat (en face) images of posterior precortical vitreous pockets (PPVPs) using swept-source optical coherence tomography (SS-OCT). METHODS. We performed SS-OCT in the right eyes of 112 volunteers (mean age, 30.1 years; mean refraction, 2.5 diopters) while sitting using 12-mm horizontal, vertical scans of the 12- 3 9-mm plane 3 2.6-mm depth through the macula and optic disc. En face images of the posterior vitreous were obtained by En-View, a SS-OCT program. RESULTS. Swept-source OCT visualized the PPVPs and Cloquet’s canals in all subjects; the PPVPs appeared as boat-shaped lacunae in the horizontal ...

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      Mentions: Gunma University
    7. Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography

      Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography

      Keratoconus is typically diagnosed through changes at the anterior ocular surface. However, we wished to assess if macular parameter changes might also occur in these patients. We assessed posterior changes through the use of optical coherence tomography and compared to a nonkeratoconus patient group. All subjects underwent clinical examination including macular thickness measurements. The generalized estimation equation model was used to estimate the means and compare the differences in various measurements between keratoconus and nonkeratoconus patients. A total of 129 keratoconus eyes of 67 cases and 174 nonkeratoconus eyes of 87 controls were analysed. Keratoconus individuals presented with a significantly ...

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    8. UTILIZATION OF FUNDUS AUTOFLUORESCENCE, SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY, AND ENHANCED DEPTH IMAGING IN THE CHARACTERIZATION OF BIETTI CRYSTALLINE DYSTROPHY IN DIFFERENT STAGES

      UTILIZATION OF FUNDUS AUTOFLUORESCENCE, SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY, AND ENHANCED DEPTH IMAGING IN THE CHARACTERIZATION OF BIETTI CRYSTALLINE DYSTROPHY IN DIFFERENT STAGES

      Purpose: To characterize Bietti crystalline dystrophy (BCD) in different stages using multiple imaging modalities. Methods: Sixteen participants clinically diagnosed as BCD were included in the retrospective study and were categorized into 3 stages according to fundus photography. Eleven patients were genetically confirmed. Fundus autofluorescence, spectral domain optical coherence tomography, and enhanced depth imaging features of BCD were analyzed. Results: On fundus autofluorescence, the abnormal autofluorescence was shown to enlarge in area and decrease in intensity with stages. Using spectral domain optical coherence tomography, the abnormalities in Stage 1 were observed to localize in outer retinal layers, whereas in Stage 2 ...

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    9. Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography

      Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography

      Purpose To evaluate the diagnostic ability of macular ganglion cell and inner plexiform layer measurements in glaucoma, obtained using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) and to compare to circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements. Methods The study included 106 glaucomatous eyes of 80 subjects and 41 eyes of 22 healthy subjects from the Diagnostic Innovations in Glaucoma Study. Macular ganglion cell and inner plexiform layer (mGCIPL), macular ganglion cell complex (mGCC) and cpRNFL thickness were assessed using SS-OCT and SD-OCT, and area under the receiver operating characteristic curves (AUCs) were calculated to ...

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    10. INTRASURGICAL MICROSCOPE-INTEGRATED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-ASSISTED MEMBRANE PEELING

      INTRASURGICAL MICROSCOPE-INTEGRATED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-ASSISTED MEMBRANE PEELING

      Purpose: To evaluate microscope-integrated intrasurgical spectral domain optical coherence tomography during macular surgery in a prospective monocenter study. Methods: Before pars plana vitrectomy and before, during, and after membrane peeling, 512 x 128 macular cube scans were performed using a Carl Zeiss Meditec Cirrus high-definition OCT system adapted to the optical pathway of a Zeiss OPMI VISU 200 surgical microscope and compared with retinal staining. Results: The study included 51 patients with epiretinal membranes, with 8 of those having additional lamellar macular holes, 11 patients with vitreomacular traction, and 8 patients with full-thickness macular holes. Intraoperative spectral domain optical coherence ...

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    11. OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy

      OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy

      Purpose To study the precise structural aspects of a type 2 neovascular membrane in a patient with age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography and perform sequential quantitative analysis of the membrane after ranibizumab therapy. Patients and methods Split-spectrum amplitude-decorrelation (SSADA) OCT angiography macular cubes (3 × 3   mm) were acquired with a light source centered at 840   nm, a bandwidth of 45   nm, and an A-scan-rate of 70   000 scans per second. Visible pathologic vessels were outlined manually on average intensity projection en face images, and the area of the lesion and the vessel density were measured ...

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    12. Symposium: Incorporation of OCT Angiography into Clinical Practice, Drug Development and Clinical Trials: Opportunities and Pitfalls. June 6th 2015, Rome, Italy

      Symposium: Incorporation of OCT Angiography into Clinical Practice, Drug Development and Clinical Trials: Opportunities and Pitfalls.  June 6th 2015, Rome, Italy

      A symposium is scheduled on June 6th in Rome Italy on the Incorporation of OCT Angiography into Clinical Practice, Drug Development and Clinical Trials: Opportunities and Pitfalls. For more information click HERE .

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    13. Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

      Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

      Purpose To describe qualitative characteristics of drusen in eyes with non-advanced age-related macular degeneration (AMD) using polarization-sensitive optical coherence tomography (OCT). Design Cross-sectional study Methods 25 eyes of 25 patients with early to intermediate (non-advanced) AMD were imaged with polarization-sensitive OCT using macular volume scans. All individual drusen in each B-scan were manually delineated by experts certified by a reading center and graded for six different morphological characteristics based on a defined classification scheme, including the presence of internal depolarizing structures and associated depolarizing foci. With the use of a custom-made software, the central B-scan of each individual druse was ...

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    14. Retinal nerve fiber layer and ganglion cell complex thicknesses measured with spectral-domain optical coherence tomography in eyes with no light perception due to nonglaucomatous optic neuropathy

      Retinal nerve fiber layer and ganglion cell complex thicknesses measured with spectral-domain optical coherence tomography in eyes with no light perception due to nonglaucomatous optic neuropathy

      PURPOSE: To measure retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex thickness (GCCT) in eyes with no light perception due to nonglaucomatous optic neuropathy using spectral-domain optical coherence tomography. METHODS: Fourteen eyes of 14 patients (9 women, 5 men; mean age 56.0 ± 16.6 (standard deviation) years] with no light perception due to optic neuropathy were recruited to this retrospective study. Only clinically stable eyes were included. Eyes were imaged at least 6 months after the onset of the disease. Five patients lost light perception due to traumatic optic neuropathy, four patients had ischemic optic neuropathy, two ...

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    15. Optical Coherence Tomography for the Identification of a Rare Case of Keratoconus in Albino Donor Cornea

      Optical Coherence Tomography for the Identification of a Rare Case of Keratoconus in Albino Donor Cornea

      Introduction Keratoconus (KC) is a corneal ectatic disorder characterized by irregular corneal surface elevation, interruptions in the Bowman’s layer, stromal thinning and degeneration [1-3]. Irregular astigmatism and myopia can cause severe visual impairment. Oculocutaneous albinism (OCA) is a group of inherited disorders of melanin biosynthesis characterized by a generalized reduction in pigmentation of hair, skin and eyes. The inheritance pattern of albinism is autosomal recessive. Mutations in the tyrosinase [TYR] gene on chromosome 11 q14-q21 are reportedly common in most cases of OCA. The inheritance patterns of keratoconus are more complex than albinism due to the involvement of environmental ...

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    16. Association of Spectral-Domain Optical Coherence Tomography Findings with Visual Outcome of Macula-Off Rhegmatogenous Retinal Detachment Surgery

      Association of Spectral-Domain Optical Coherence Tomography Findings with Visual Outcome of Macula-Off Rhegmatogenous Retinal Detachment Surgery

      Purpose: To identify prognostic factors for the visual outcome for patients with macula-off rhegmatogenous retinal detachment (RRD). Methods: The medical records of 27 patients (27 eyes) with macula-off RRD were retrospectively investigated. In addition to clinical characteristics, spectral-domain optical coherence tomography (SD OCT) images were analyzed. Results: The central foveal thickness at baseline was 923 ± 499.5 µm, and the mean height of the subretinal fluid was 697.8 ± 463.6 µm. Dropout of backreflection at the fovea was detected on preoperative SD OCT in 8 patients (29.6%). The external limiting membrane was disrupted in 5 patients (18.5 ...

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    17. Effects of Retinal Angiography on Optical Coherence Tomography Measurements

      Effects of Retinal Angiography on Optical Coherence Tomography Measurements

      Purpose: To evaluate the effects of retinal angiography, using fluorescein and indocyanine green dyes, on optical coherence tomography (OCT) measurements. Methods: In total, 76 eyes from 76 consecutive patients were included. Macular cube 512 × 128 combination scanning and optic disc 200 × 200 scanning using spectral-domain (SD)-OCT were performed twice, before and after retinal angiography, with fluorescein or indocyanine green. Signal strength, regional retinal thickness of the 9 Early Treatment Diabetic Retinopathy Study subfields, total macular volume, and retinal nerve fiber layer thickness obtained before and after angiography were compared. Repeatability was also investigated. Results: Comparing the results of OCT ...

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    18. NIDEK launches MP-3 Microperimeter

      NIDEK launches MP-3 Microperimeter

      NIDEK CO., LTD., a global leader in the design, manufacture, and distribution of ophthalmic, optometric, and lens edging equipment, is pleased to announce the launch of the MP-3 Microperimeter. Assessment of retinal morphology has advanced significantly due to the introduction of Optical Coherence Tomography into clinical practice. Advances in the functional evaluation of retinal pathology are due to the use of the microperimeter. The MP-3 measures local retinal sensitivity for functional assessment of the retina. The results can be displayed over a color fundus image, correlating retinal anatomy to retinal function. For enhanced clinical assessment, the MP-3 now includes a ...

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      Mentions: Nidek
    19. Computer-aided analyses of mouse retinal OCT images – an actual application report

      Computer-aided analyses of mouse retinal OCT images – an actual application report

      Purpose There is a need for automated retinal optical coherence tomography (OCT) image analysis tools for quantitative measurements in small animals. Some image processing techniques for retinal layer analysis have been developed, but reports about how useful those techniques are in actual animal studies are rare. This paper presents the use of a retinal layer detection method we developed in an actual mouse study that involves wild type and mutated mice carrying photoreceptor degeneration. Methods Spectral domain OCT scanning was performed by four experimenters over 12 months on 45 mouse eyes that were wild-type, deficient for ephrin-A2 and ephrin-A3, deficient ...

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    20. Macular morphologic findings on optical coherence tomography after microincision vitrectomy for proliferative diabetic retinopathy

      Macular morphologic findings on optical coherence tomography after microincision vitrectomy for proliferative diabetic retinopathy

      Purpose To investigate macular morphology on spectral-domain optical coherence tomography (SD-OCT) images after microincision vitrectomy for vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). Methods In this retrospective case series, 69 eyes (57 consecutive patients) that underwent 23-gauge microincision vitrectomy for vitreous hemorrhage due to PDR were investigated. Qualitative and quantitative characteristics on SD-OCT images [central retinal thickness, external limiting membrane (ELM), and the ellipsoid zone, epiretinal membranes involving the fovea, and hyperreflective foci at the fovea] were assessed 6 months postoperatively. Their association with the logarithm of the minimum angle of resolution visual acuity (logMAR VA) was evaluated. Results ...

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    21. Repeatability of tear meniscus evaluation using spectral-domain Cirrus® HD-OCT and time-domain Visante® OCT

      Repeatability of tear meniscus evaluation using spectral-domain Cirrus® HD-OCT and time-domain Visante® OCT

      Purpose To investigate the intra-rater, inter-rater and inter-device repeatability of a spectral-domain OCT (Cirrus) and a time-domain OCT (Visante) for tear meniscus height (TMH) and area (TMA) measurements. Methods 20 participants with no known eye disease were recruited. Both eyes of participants were imaged with both OCTs under the similar conditions. The inferior tear meniscus was imaged at 6 o’clock position whereas the superior meniscus was imaged at 12 o’clock position. Data from the right eyes was analyzed. Two raters independently measured TMH and TMA using the OCT images, and one rater repeated the measurements. Intra-rater, inter-rater and ...

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    22. Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry

      Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry

      Optical coherence tomography (OCT) oximetry explores the possibility to measure retinal hemoglobin oxygen saturation level (sO2). We investigated the accuracy of OCT retinal oximetry using Monte Carlo simulation in a commonlyused four-layer retinal model. After we determined the appropriate number of simulated photon packets, we studied the effects of blood vessel diameter, signal sampling position, physiological sO2 level, and the blood packing factor on the accuracy of sO2 estimation in OCT retinal oximetry . The simulation results showed that a packing factor between 0.2 and 0.4 yields a reasonably accurate estimation of sO2 within a 5% error tolerance, which ...

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    23. Normative data for macular volume with high-definition spectral-domain optical coherence tomography (Spectralis)

      Normative data for macular volume with high-definition spectral-domain optical coherence tomography (Spectralis)

      To establish normative data for macular volume by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease. In an academic institutional setting, 50 subjects (age range 20-84 years) with no known retinal disease, best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. The subjects were divided into 3 age groups: group 1 included subjects 20-40 years of age, group 2 included subjects 41-60 years of age, and group 3 included subjects 61 years of age and older. All subjects underwent a complete ophthalmologic examination and testing, if needed, to rule out any retinal diseases or ...

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