1. Articles in category: Ophthalmology

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    1. PARAFOVEAL MICROVASCULAR FEATURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

      PARAFOVEAL MICROVASCULAR FEATURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

      Purpose: To evaluate parafoveal microvasculature in eyes with circumscribed choroidal hemangioma using optical coherence tomography angiography. Methods: Fourteen eyes with unilateral circumscribed choroidal hemangioma were imaged using OCT for central macular thickness and optical coherence tomography angiography for superficial and deep foveal avascular zone area, and superficial and deep capillary density (CD), comparing affected and paired fellow eyes. Results: Mean patient age was 53 years, and mean visual acuity was 20/60 in the involved eye and 20/25 in the fellow eye. In the affected eye, clinical findings included cystoid macular edema (CME) in 1, parafoveal/subfoveal subretinal fluid ...

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    2. Anterior segment optical coherence tomography and retained vegetal intraocular foreign body masquerading as chronic anterior uveitis

      Anterior segment optical coherence tomography and retained vegetal intraocular foreign body masquerading as chronic anterior uveitis

      Background The purpose of this single case report was to report the use of anterior segment optical coherence tomography for the diagnosis and management of a retained vegetal intraocular foreign body. Results A 23-year-old otherwise healthy male presented with a progressive vision loss in the right eye (RE). He reported a mild ocular trauma with a tree leaf 1 year ago followed by recurrent episodes of redness and pain in the RE that partially resolved after a self-medication with topical steroids. Visual acuity of the RE was limited to light perception. Slit-lamp examination of the RE showed an iris granuloma ...

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    3. MORPHOFUNCTIONAL EVALUATION IN DOME-SHAPED MACULA: A MICROPERIMETRY AND OPTICAL COHERENCE TOMOGRAPHY STUDY

      MORPHOFUNCTIONAL EVALUATION IN DOME-SHAPED MACULA: A MICROPERIMETRY AND OPTICAL COHERENCE TOMOGRAPHY STUDY

      Purpose: To investigate retinal sensitivity (Se) in dome-shaped macula (DSM) using microperimetry and to correlate functional findings to specific spectral domain optical coherence tomography features. Methods: Patients affected by DSM in at least 1 eye were consecutively enrolled in a prospective, cross-sectional study. All studied eyes performed best-corrected visual acuity measurement, microperimetry to assess Se and optical coherence tomography to investigate DSM pattern and to measure bulge height and retinal and choroidal thicknesses. Results: Fifty-three eyes of 29 patients were studied. Dome-shaped macula was vertically oriented (V-DSM) in 23 (43.4%), symmetric (S-DSM) in 17 (32.1%), and horizontally oriented ...

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    4. MULTIMODAL IMAGING OF ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY

      MULTIMODAL IMAGING OF ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY

      Purpose: To report a case of acute exudative polymorphous vitelliform maculopathy including the findings of optical coherence tomography angiography and adaptive optics scanning laser ophthalmoscopy. Methods: Findings on clinical examination, color fundus photography, spectral-domain optical coherence tomography, infrared reflectance, autofluorescence, optical coherence tomography angiography, and adaptive optics scanning laser ophthalmoscopy. Results: A 54-year-old white man with no significant medical history and history of smoking presented with bilateral multiple serous and vitelliform detachments consistent with acute exudative polymorphous vitelliform maculopathy. Extensive infectious, inflammatory, and malignancy workup was negative. Spectral-domain optical coherence tomography showed thickened, hyperreflective ellipsoid zone, subretinal fluid, and focal ...

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    5. A Case of Retinal Cavernous Hemangioma Diagnosed with Spectral Domain Optical Coherence Tomography

      A Case of Retinal Cavernous Hemangioma Diagnosed with Spectral Domain Optical Coherence Tomography

      Dear Editor, Retinal cavernous hemangioma (RCH) is a rare, benign, congenital vascular anomaly, incidentally diagnosed in asymptomatic patients. Its characteristics were first reported by Gass [ 1 ] in 1971, as multiple saccular intraretinal aneurysms with dark red color. In most cases, RCH presents with no symptoms, but sometimes it causes visual deterioration when the lesion involves macular and/or vitreous hemorrhage. Several reports have demonstrated that RCH may accompany cutaneous and central nervous system angiomatous lesions, so that RCH could be classified as part of a neuro-oculocutaneous syndrome [ 2 , 3 ]. The lesions are mostly located in the inner retinal layer or ...

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    6. Optical coherence tomography angiography wide-field montage in branch retinal vein occlusion before and after anti-vascular endothelial-derived growth factor injection

      Optical coherence tomography angiography wide-field montage in branch retinal vein occlusion before and after anti-vascular endothelial-derived growth factor injection

      The wide-field montage technique of optical coherence tomography angiography provides good delineation of the improvement in microvascular disturbance associated with branch retinal vein occlusion after treatment with anti-vascular endothelial-derived growth factor injection. It may be further evaluated for the assessment of treatment progress in patients with retinal vein occlusion.

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    7. New algorithm helps interpret vision loss

      New algorithm helps interpret vision loss

      Researchers at the University of Melbourne have developed technology that can take a three-dimensional image of the inside of the human eye , revolutionising eye care. These images are especially suited to detecting and monitoring two of the most common causes of progressive vision loss: glaucoma and age-related macular degeneration. Advances in computing power and LCD screen technology have both contributed to the adoption of digital imaging in eye care. However, the brain plays such a powerful role in generating our sense of sight that damage to the light-sensing retina does not necessarily result in a one-to-one corresponding loss of vision ...

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    8. A Potential of Mechanism of Retinal Injury

      A Potential of Mechanism of Retinal Injury

      Purpose: To investigate the structural optical coherence tomography and related microvascular flow characteristics in eyes with retinal vasculitis. Methods: Regions involved with perivascular infiltration in eyes with retinal vasculitis, but no evidence of large vessel occlusion were evaluated with optical coherence tomography (OCT), OCT angiography, and fluorescein angiography. Results: Ten eyes of 5 patients with a variety of etiologies of retinal vasculitis were evaluated. These patients did not have either cotton wool spots or deeper placoid areas of retinal ischemia. Around large vessels there was perivascular infiltration with leakage and staining seen during fluorescein angiography. Structural OCT showed slight thickening ...

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    9. B-Scan and En Face Spectral Domain Optical Coherence Tomography Evaluation

      B-Scan and En Face Spectral Domain Optical Coherence Tomography Evaluation

      Purpose: To evaluate hyperreflective retinal spots (HRS), in normal subjects and diabetic patients without and with macular edema (diabetic macular edema, DME), on linear B-scans and corresponding en face image of spectral-domain optical coherence tomography. Methods: Retrospective evaluation of images of 54 eyes/subjects (16 normal subjects, 19 diabetic patients without DME, and 19 with DME). On horizontal B-scan spectral-domain optical coherence tomography, passing through the center of the fovea, the following characteristics of HRS were evaluated: location (inner retina or outer retina), size (≤30 or >30 μ m), reflectivity (similar to nerve fiber layer or to retinal pigment epithelium–Bruch ...

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    10. A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration

      A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration

      Purpose: To evaluate choroidal structural changes in exudative age-related macular degeneration (AMD) using choroidal vascularity index computed from image binarization on spectral domain optical coherence tomography with enhanced depth imaging. Methods: This prospective case series included 42 consecutive patients with unilateral exudative AMD. Choroidal images were segmented into luminal area and stromal area. Choroidal vascularity index was defined as the ratio of luminal area to total choroid area. Mean choroidal vascularity index and mean choroidal thickness between study and fellow eyes of the same patient with dry AMD were compared using Student's t -test. Results: There was a significantly ...

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    11. Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      Purpose: To evaluate changes of vascular flow of patients treated with intravitreal injections of anti-vascular endothelial growth factor for macular edema secondary to retinal vein occlusion (RVO) with optical coherence tomography angiography (OCTA). Methods: Patients with RVO with macular edema and treated with intravitreal injections of anti-vascular endothelial growth factors were retrospectively evaluated. The following examinations were performed before and after treatment: best-corrected visual acuity, spectral domain optical coherence tomography, fluorescein angiography, and OCTA (Optovue, Inc). Automatic measurement of vascular density of the superficial and deep capillary plexus was also performed and compared with age- and sex-matched healthy subjects. Results ...

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    12. Detection of progression of glaucomatous retinal nerve fibre layer defects using optical coherence tomography-guided progression analysis

      Detection of progression of glaucomatous retinal nerve fibre layer defects using optical coherence tomography-guided progression analysis

      Purpose The aim was to investigate the agreement for detection of progression of glaucomatous retinal nerve fibre layer defects (RNFLD) between optical coherence tomography-guided progression analysis (OCT GPA) and conventional red-free fundus photography. Methods Four hundred and fifteen glaucomatous eyes that underwent at least four serial red-free photographic and OCT examinations were included in the study. Based on the inspection of the red-free fundus photographs and GPA maps, RNFLD progression was defined as the development of a new defect, widening or deepening of a pre-existing RNFLD in red-free fundus photography (photographic progression) or ‘Likely Loss’ on a GPA map (GPA ...

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    13. Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography

      Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography

      Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third ...

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    14. Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis

      Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis

      This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as well as parameters useful for evaluating the properties. The methods and systems described herein are useful as eye disease diagnostic tools and eye surgery planning tools.

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    15. Ganglion Cell–Inner Plexiform Layer Change Detected by Optical Coherence Tomography Indicates Progression in Advanced Glaucoma

      Ganglion Cell–Inner Plexiform Layer Change Detected by Optical Coherence Tomography Indicates Progression in Advanced Glaucoma

      Purpose To examine the performance of Guided Progression Analysis (GPA; Carl Zeiss Meditec, Dublin, CA) in spectral-domain optical coherence tomography (OCT) in detecting progressive thinning of ganglion cell–inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in glaucoma. Design Longitudinal, observational study. Participants A total of 196 eyes of 123 primary open-angle glaucoma patients (mean follow-up, 5.0 years). Methods Macular GCIPL and peripapillary RNFL thicknesses were measured by Cirrus HD-OCT (Zeiss, Dublin, CA), and progressive GCIPL and RNFL thinning were assessed by GPA. The reference standard of glaucoma progression was determined by visual field (VF) progression. Glaucomatous ...

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    16. Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy

      Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy

      Purpose To quantify retinal structure and progression using spectral-domain optical coherence tomography (SDOCT) in patients with retinitis pigmentosa (RP) associated with retinitis pigmentosa GTPase regulator gene ( RPGR ) mutations. Design Retrospective observational case series. Methods Setting : Moorfields Eye Hospital, London, United Kingdom. Subjects : Both eyes of 32 patients. SDOCT follow-up period of >1 year (3.1 ± 1.4 years). Main Outcome Measures : Ellipsoid zone (EZ) width (EZW) and outer nuclear layer (ONL) and inner retinal layer (IRL) thickness measurements. Progression rates, interocular symmetry, and association with age and genotype were investigated. Results Significant differences were observed between baseline and final measurements ...

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      Mentions: Joseph Carroll
    17. OCT rollout announced for all Specsavers stores

      OCT rollout announced for all Specsavers stores

      Specsavers is to invest in a multi-million pound programme to offer optical coherence tomography (OCT) to patients in each of its 740 practices across the UK. The nationwide rollout begins next month and is expected to be completed within two years. Around 35 practices already offer OCT. Specsavers co-founder and optometrist, Doug Perkins , says: ‘This is simply the right thing to do in terms of offering our patients a choice of the best possible technology in their eye examination. ‘By allowing us to examine the eye in more detail than ever before, the OCT scan will help us to identify ...

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    18. Bartonella Quintana–associated Neuroretinitis: Longitudinal Spectral-Domain Optical Coherence Tomographic Findings

      Bartonella Quintana–associated Neuroretinitis: Longitudinal Spectral-Domain Optical Coherence Tomographic Findings

      Purpose: To report an unusual case of neuroretinitis caused by Bartonella quintana and its spectral-domain optical coherence tomographic (SD-OCT) features. Methods: A 12-year-old girl presented with unilateral neuroretinitis with stellate maculopathy. Bartonellosis was confirmed after serologic testing for antibodies to B. quintana . Results: Color photograph of the right eye revealed papillitis and stellate macular exudation. spectral-domain optical coherence tomography of the right eye revealed hyperreflective dots in the outer nuclear and outer plexiform layers, as well as disruption and loss of the external limiting membrane, ellipsoid zone, and interdigitation zone in the foveal area. Conclusion: The authors report an unusual ...

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    19. Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography

      Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography

      Purpose To describe the retinochoroidal vascular alterations in patients with human immunodeficiency virus (HIV) infection using en face OCT angiography (OCTA). Design Cross-sectional study. Participants Twenty-six patients with HIV infection (5 women, with and without HIV retinopathy) were included in the study. Nineteen healthy participants (7 women) with no known ocular disease were recruited as healthy controls. Methods Multimodal imaging was performed using OCTA (Optovue RTVue XR Avanti; Optovue, Inc, Fremont, CA), enhanced-depth imaging OCT (Heidelberg Spectralis; Heidelberg Engineering, Heidelberg, Germany), color fundus photography, and fluorescein angiography (FA). Vessel flow density (VFD) was calculated automatically by the OCTA software. Morphologic ...

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    20. Foveal Curvature and Asymmetry Assessed Using Optical Coherence Tomography

      Foveal Curvature and Asymmetry Assessed Using Optical Coherence Tomography

      Purpose: The aims of this study were to use cross-sectional optical coherence tomography imaging and custom curve fitting software to evaluate and model the foveal curvature as a spherical surface and to compare the radius of curvature in the horizontal and vertical meridians and test the sensitivity of this technique to anticipated meridional differences. Methods: Six 30-degree foveal-centered radial optical coherence tomography cross-section scans were acquired in the right eye of 20 clinically normal subjects. Cross sections were manually segmented, and custom curve fitting software was used to determine foveal pit radius of curvature using the central 500, 1000, and ...

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    21. RE: Traber et al.: Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss (Ophthalmology. 2017;124:66-73)

      RE: Traber et al.: Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss (Ophthalmology. 2017;124:66-73)

      To the Editor: We read with interest the study by Traber et al, where the presence or absence of visual field defects was correlated with optic nerve head drusen (ONHD) morphology. 1 The ONHD were classified using enhanced depth imaging optical coherence tomography (OCT) morphologic characteristics as either peripapillary, granular, or confluent. The hyperreflective structures classified as peripapillary ONHD in the present study have previously been labeled as ONHD 2 ; however, we do not find substantial evidence for this suggestion. First, we regularly see similar hyperreflective mass-like peripapillary changes in OCT volume scans of patients with papilledema from idiopathic intracranial ...

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    22. Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      To the Editor: We read with interest the study by Goto et al, 1 who described a new formula to predict the postoperative position of the intraocular lens (IOL). Although their results are interesting and might be useful for IOL power calculation, we feel that some comments are necessary. First, comparing what they define as the “postoperative external anterior chamber depth,” either measured or predicted by anterior segment optical coherence tomography, to the IOL position, as predicted by thin lens formulas, is not the proper method. The measurements performed by the authors, in fact, refer to a thick lens system ...

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      Mentions: Giacomo Savini
    23. Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy

      Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy

      A 24-year-old woman with type I diabetes mellitus with significant macular ischemia in her left eye with a large net of neovascularization of the disc (Fig 1A). There is profound retinal capillary nonperfusion contrasting with perfusion of the neovascularization of the disc demonstrated on a full thickness 6×6-mm optical coherence tomography−angiography scan (Fig 1B), using Angiovue software (Optovue, Inc. Fremont, CA).

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      Mentions: Optovue
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