Ophthalmology -Optical Coherence Tomography News

Articles in category: Ophthalmology

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1. Vascular and Structural Alterations of the Choroid Evaluated by Optical Coherence Tomography Angiography and Enhanced-Depth Imaging Optical Coherence Tomography in Eyes with Reticular Pseudodrusen and Soft Drusen
  
  Explore ScienceDirect Sep 26 2021 Ophthalmology
  
  Background To assess the vascularity of choriocapillaris and structural choroidal differences in eyes with reticular pseudodrusen (RPD) and soft drusen. Methods 21 eyes with RPD (group 1), 17 eyes with soft drusen (group 2), and 19 eyes as a control group (group 3) were included in this study. Choriocapillaris vascular density and flow area were measured by optical coherence tomography angiography. Total choroidal area, luminal area, stromal area, and lumen/stroma ratios were measured on optical coherence tomography B-scans converted to binary images. Results Mean choriocapillaris vascular density was higher in group 3 than other groups (group 1 vs 3 ...
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2. Total venous nature of retinal deep capillary plexus inferred by continuity of prominent middle limiting membrane sign in optical coherence tomography
  
  Explore Journals | PLOS Sep 26 2021 Ophthalmology
  
  This study aimed to theoretically identify the vascular nature of the deep capillary plexus (DCP) by examining patients presenting with both paracentral acute middle maculopathy (PAMM) and prominent middle limiting membrane (p-MLM) sign and p-MLM sign alone in spectral-domain optical coherence tomography (SD-OCT). A retrospective review of the medical records of patients with retinal vein or artery occlusion from two tertiary medical centers was performed. Consecutive patients with a clinical diagnosis of all categories of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) (branch or central and ischemic or non-ischemic) who had undergone SD-OCT imaging from January 2015 to ...
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3. A New Method for Automating the Diagnostic Analysis of Human Fundus Images Obtained Using Optical Coherent Tomography Angiography
  
  Explore Home - Springer Sep 26 2021 Ophthalmology
  
  This article presents the results of the joint work of image analysis specialists and ophthalmologists on the problem of analyzing images obtained by optical coherence tomography (angiography). A descriptive algorithmic scheme for analyzing images obtained using optical coherence tomography angiography was constructed to automate detection of pathological changes in the morphometric characteristics of the fundus. The algorithmic scheme is based on the image processing, analysis, and recognition methods. A feature space has been developed that makes it possible to identify pathological changes in the structure of the vascular plexuses of the human retina. It was possible to achieve high-accuracy classification ...
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4. Quantifying Retinal Microvascular Morphology in Schizophrenia Using Swept-Source Optical Coherence Tomography Angiography
  
  Explore Journals Sep 26 2021 Neurology , Ophthalmology
  
  Background: Retinovascular changes are reported on fundus imaging in schizophrenia (SZ). This is the first study to use swept-source optical coherence tomography angiography (OCT-A) to comprehensively examine retinal microvascular changes in SZ. Methods: This study included 30 patients with SZ/schizoaffective disorder (8 early and 15 chronic) and 22 healthy controls (HCs). All assessments were performed at Beth Israel Deaconess Medical Center and Massachusetts Eye and Ear. All participants underwent swept-source OCT-A of right (oculus dextrus [OD]) and left (oculus sinister [OS]) eye, clinical, and cognitive assessments. Macular OCT-A images (6 × 6 mm) were collected with the DRI Topcon Triton ...
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  Mentions: Beth Israel Deaconess Medical Center Topcon Medical Systems
5. Human Foveal Cone and Müller Cells Examined by Adaptive Optics Optical Coherence Tomography
  
  Explore TVST Journal Sep 26 2021 Ophthalmology
  
  Purpose: The purpose of this study was to image and investigate the foveal microstructure of human cone and Müller cells using adaptive optics-optical coherence tomography. Methods: Six healthy subjects underwent the prototype adaptive optics-optical coherence tomography imaging, which allowed an axial resolution of 3.4 µm and a transverse resolution of approximately 3 µm. The morphological features of the individual retinal cells observed in the foveola were qualitatively and quantitatively evaluated. Results: In the six healthy subjects, the image B-scans showed hyper-reflective dots that were densely packed in the outer nuclear layer. The mean number, diameter, and density of ...
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  Mentions: Kyoto University Graduate School of Medicine
6. Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography
  
  Explore American Journal of Ophthalmology Sep 26 2021 Ophthalmology
  
  We read with interest the manuscript by Bansal and associates 1 regarding optical coherence tomography (OCT) to assess retinal reattachment following successful pneumatic retinopexy (PnR). The authors propose that retinal reattachment occurs through 5 specific stages: approach of the neurosensory retina towards the retinal pigment epithelium (RPE, stage 1), improvement of outer retinal corrugations (stage 2), contact of the neurosensory retina to the RPE (stage 3), deturgescence of the photoreceptors (stage 4) and recovery of photoreceptor integrity (stage 5). An incomplete resolution of outer retinal corrugations before retinal reattachment may lead, according to the authors, to the formation of outer ...
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7. Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning
  
  Explore American Journal of Ophthalmology Sep 25 2021 Ophthalmology
  
  Purpose To develop deep learning models for identification of sex and age from macular optical coherence tomography (OCT), and to analyze the features for differentiation of sex and age. Design Algorithm development using database of macular OCT. Setting One eye center in Taiwan. Study Population 6147 sets of macular optical coherence tomography (OCT) images from the healthy eyes of 3134 persons. Main Outcome Measures Deep learning based algorithms were used to develop models for identification of sex and age, and 10-fold cross-validation was applied. Gradient-weighted class activation mapping (Grad-CAM) was used for feature analysis. Results The accuracy for sex prediction ...
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8. Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography
  
  Explore American Journal of Ophthalmology Sep 25 2021 Ophthalmology
  
  Purpose To evaluate the ocular and systemic determinants of the choriocapillaris flow deficits percentage (CC FD%) in normal eyes. Design Observational cross-sectional study. Methods Healthy Chinese participants without ocular or systemic diseases underwent detailed ophthalmic evaluations, including swept-source optical coherence tomography angiography (SS-OCTA) with 6 × 6 mm macular choriocapillaris images. The CC FD% was assessed in circular regions with diameters of 1.0 and 5.0 mm, rings with 1.0–2.5-mm and 2.5–5.0-mm diameters. Results The study included 830 individuals (mean age: 58.66±8.75 years). CC FD% (mean: 22.05%±1.13%) was ...
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  Mentions: Topcon Medical Systems Sun Yat-Sen University Haag-Streit
9. OCTA Insights in CNVM, Morphological Characteristics and Correlation With Structural OCT.
  
  Explore Home - ClinicalTrials.gov Sep 24 2021 Ophthalmology , Clinical Trials
  
  To suggest a novel classification of choroidal neovascular membrane based on optical coherence tomography angiography and to correlate morphological characteristics based on optical coherence tomography with clinical criteria of disease activity.
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10. Comparison of inner macular thickness and superficial macular capillary vessel density acquired using classic and high-definition optical coherence tomography angiography scans
  
  Explore maio-journal.com Sep 24 2021 Ophthalmology
  
  Background: In ophthalmology, thickness and vessel density (VD) measurements for the 6 x 6 mm inner macular retinal area have received increasing attention in glaucomatous progression research. For this area, the Angiovue optical coherence tomography system introduced a 304 x 304 A/B scans function (classic Angio Retina scan) in 2014, and a 400 x 400 A/B scans function (high-definition [HD] Angio Retina scan) in 2017. These scan types cannot be used in combination for the software provided for progression analysis. Purpose: Since losing data for 3 years may negatively influence progression analysis, we investigated whether clinically significant differences ...
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11. Neuro-ophthalmological diseases masquerading as glaucoma in the Optical Coherence Tomography era: A case series
  
  Explore Journal Sep 24 2021 Ophthalmology
  
  Background: Intracranial compressive lesions masquerading as glaucomatous optic neuropathy have been previous ly described in the literature but remain a diagnosis challenge for trained physicians. We present a case series of patients referred to our center as glaucoma suspects or diagnosed with glaucoma, looking for a second opinion. We aim to highlight how clini cal clues and Optical Coherence Tomography (OCT) findings helped identify a condition different from glaucoma. Case presentation: A 55 - year - old male presented a painless decrease in his visual acuity and elevated intraocular pressure of both eyes. His OCT revealed Ganglion Cell Layer thinning, and Humphrey ...
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12. Uncertainty-guided self-ensembling model for semi-supervised segmentation of multiclass retinal fluid in optical coherence tomography images
  
  Explore Wiley Online Library Sep 24 2021 Ophthalmology
  
  Macular edema is the accumulation of fluid leakage from retinal capillaries. Optical coherence tomography (OCT) images can show changes in the retinal tissue caused by ophthalmological diseases, such as fluid accumulation. Therefore, the segmentation of retinal fluid is important. Some methods based on image processing and machine learning often require large amounts of labeled data and rich domain knowledge. This study proposes a self-ensembling semi-supervised model based on uncertainty guidance, namely, UGNet. The model is trained end-to-end with a few labeled data and plenty of unlabeled data, and contains a teacher model and a student model with the same architecture ...
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13. Deep-learning based retinal fluid segmentation in optical coherence tomography images using a cascade of ENets
  
  Explore bioRxiv.org Sep 24 2021 Ophthalmology
  
  Optical coherence tomography (OCT) is a non-invasive, painless and reproducible examination which allows ophthalmologists to visualize retinal layers. This imaging modality is useful to detect diseases such as diabetic macular edema (DME) or age related macular degeneration (AMD), which are associated with fluid accumulations. In this paper, a cascade of deep convolutional neural networks is proposed using ENets for the segmentation of fluid accumulations in OCT B-Scans. After denoising the B-Scans, a first ENet extracts the region of interest (ROI) between the inner limiting membrane (ILM) and the Bruch's membrane (BM), whereas the second ENet segments the fluid in ...
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14. Standardization of Optical Coherence Tomography Angiography Imaging Biomarkers in Diabetic Retinal Disease
  
  Explore Karger Publishers Sep 24 2021 Ophthalmology
  
  Optical coherence tomography Angiography (OCT-A) represents a revolution in the noninvasive evaluation of retinal and choroidal circulation especially in detecting early clinical signs of diabetic retinal disease (DRD). With appropriate use, OCT-A characteristics and measurements have the potential to become new imaging biomarkers in managing and treating DRD. Major challenges include (a) provision of standardized outputs from different OCT-A instruments providing standardized terminology to correctly interpret data; (b) the presence of artifacts; (c) the absence of standardized grading or interpretation method in the evaluation of DRD, similar to that already established in fundus photography; and (d) establishing how OCT-A might ...
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15. Retinal optical coherence tomography and magnetic resonance imaging in neuromyelitis optica spectrum disorders and MOG-antibody associated disorders: an updated review
  
  Explore Taylor & Francis Online Sep 23 2021 Ophthalmology
  
  Introduction: Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein IgG antibody associated disorders (MOGAD) comprise two groups of rare neuroinflammatory diseases that cause attack-related damage to the central nervous system (CNS). Clinical attacks are often characterized by optic neuritis, transverse myelitis, and to a lesser extent, brainstem encephalitis/area postrema syndrome. Retinal optical coherence tomography (OCT) is a non-invasive technique that allows for in vivo thickness quantification of the retinal layers. Apart from OCT, magnetic resonance imaging (MRI) plays an increasingly important role in NMOSD and MOGAD diagnosis based on the current international diagnostic criteria. Retinal OCT and brain ...
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16. Modular deep neural networks for automatic quality control of retinal optical coherence tomography scans
  
  Explore ScienceDirect Sep 23 2021 Ophthalmology
  
  Retinal optical coherence tomography (OCT) with intraretinal layer segmentation is increasingly used not only in ophthalmology but also for neurological diseases such as multiple sclerosis (MS). Signal quality influences segmentation results, and high-quality OCT images are needed for accurate segmentation and quantification of subtle intraretinal layer changes. Among others, OCT image quality depends on the ability to focus, patient compliance and operator skills. Current criteria for OCT quality define acceptable image quality, but depend on manual rating by experienced graders and are time consuming and subjective. In this paper, we propose and validate a standardized, grader-independent, real-time feedback system for ...
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  Mentions: UC Irvine
17. Anterior segment OCT application in quantifying posterior capsule opacification severity with varied intraocular lens designs
  
  Explore ies.ijo.cn Sep 23 2021 Ophthalmology
  
  Aim: To evaluate the application of anterior segment-optical coherence tomography (AS-OCT) in posterior capsule opacification (PCO) severity assessment and analyse the relationship between PCO severity and intraocular lens (IOL) characters. Methods: PCO patients were prospectively recruited. Cross-sectional images of the anterior segment at horizontal and vertical meridians were acquired with AS-OCT. The area of the IOL-PC (posterior capsular) space and PCO severity (area, thickness, and density at 3 mm and 5 mm IOL optic regions) were measured. The relationship between PCO severity and visual acuity, comparisons of PCO severity and IOL-PC space using varied IOL designs were analysed. Results: One ...
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18. Retinal Optical Coherence Tomography in Neuromyelitis Optica
  
  Explore Neurology Sep 23 2021 Neurology , Ophthalmology
  
  Background and objectives: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts. Methods: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs). Participants underwent OCT with central reading including quality control and intraretinal segmentation. The primary outcome was thickness of combined ganglion cell and inner plexiform (GCIP) layer; secondary ...
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  Mentions: University of Michigan UC Irvine University of Utah
19. Comparison of the Thickness of the Fiber Layer of the Retinal Nerves in Spectral Domain Optical Coherence Tomography in Normal Eyes Older Than 40 Years
  
  Explore thieme-connect.de Sep 23 2021 Ophthalmology
  
  Purpose: To compare measurements of the thickness of the retinal nerve fibre layer (RNFL) and assess the agreement between three different devices for spectral domain optical coherence tomography. Material and methods: The RNFL thickness of both eyes of 23 normal subjects older than 40 years was measured using Canon HS100, Topcon Maestro, and NIDEK RS-3000 devices. Both eyes of each subject were scanned in random order. All scans were completed on the same day in the morning. The average and four quadrants (superior, inferior, nasal, and temporal) of RNFL thickness were measured. To determine the differences in RNFL thickness, analysis ...
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  Mentions: Nidek Topcon Medical Systems
20. OCT-A evaluation of radiation vasculopathy following slotted plaque brachytherapy
  
  Explore SAGE Journals Sep 22 2021 Ophthalmology
  
  Purpose: To determine a reliable diagnostic method to reveal and monitor subclinical progression of neural and perineural radiation vasculopathy. Methods: A retrospective cross-sectional study, where optical coherence tomography angiography (OCT-A) imaging data was collected and analyzed from 22 consecutive patients that had been treated with circumneural slotted plaque brachytherapy for peripapillary, juxtapapillary, or circumpapillary choroidal melanomas. Pre-operative dosimetry of palladium-103 radiation dose to the optic nerve and fovea were collected. Quantified differences in OCT-A-measured vessel density and length in treated verses untreated contralateral control eyes were collected. Vessel density and length were correlated to radiation dose, plaque slot depth, visual ...
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21. Spectral domain optical coherence tomography-based retinochoroidal cystine crystal score: a window into infantile nephropathic cystinosis
  
  Explore BJO Online Sep 22 2021 Ophthalmology
  
  PRÉCIS: Cystinosis is a lysosomal storage disease leading to an accumulation of cystine crystals in several organs. We aim to comprehensively describe chorioretinal cystine crystals via spectral domain optical coherence tomography (SD-OCT) and elaborate a new biomarker for systemic disease control. Background/aims: Cystinosis is a rare lysosomal storage disease leading to an accumulation of cystine crystals in several organs. This study aims to describe the deposition of retinochoroidal crystals in infantile nephropathic cystinosis and to elucidate their potential value as an objective biomarker for systemic disease control. Methods: This cross-sectional study was carried out by the University Eye ...
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  Mentions: Ludwig Maximilian University of Munich
22. Prediction of keratoconus progression using deep learning of anterior segment optical coherence tomography maps
  
  Explore Home Sep 22 2021 Ophthalmology
  
  Background: To predict keratoconus progression using deep learning of the color-coded maps measured with a swept-source anterior segment optical coherence tomography (As-OCT) device. Methods: We enrolled 218 keratoconic eyes with and without disease progression. Using deep learning of the 6 color-coded maps (anterior elevation, anterior curvature, posterior elevation, posterior curvature, total refractive power, and pachymetry map) obtained by the As-OCT (CASIA, Tomey), we assessed the accuracy, sensitivity, and specificity of prediction of keratoconus progression in such eyes. Results: Deep learning of the 6 color-coded maps exhibited an accuracy of 0.794 in discriminating keratoconus with and without progression. For a ...
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  Mentions: Tomey Corporation
23. Age and signal strength-related changes in vessel density in the choroid and the retina: an OCT angiography study of the macula and optic disc
  
  Explore Wiley Online Library Sep 22 2021 Ophthalmology
  
  Purpose: To investigate the effects of ageing and signal strength index (SSI) on vessel density (VD) measurements of the radial peripapillary capillaries (RPC) in the optic disc, the retinal superficial (SCP) and deep (DCP) capillary plexi and the choriocapillaris (CC) of the macular area using optical coherence tomography angiography (OCT-A) imaging. Methods: This cross-sectional study included 138 eyes from 77 healthy participants. High-definition (HD) disc Angio scan (4.5X4.5 mm) and HD Angio retina scan (6X6 mm) were acquired. Whole image (WI) VDs, inside disc (ID) VD and global and hemifield peripapillary RPC VDs were evaluated from the Angio ...
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24. Implications of SS-OCT-anterior scleral thickness biometry on the definition of nanophthtalmos
  
  Explore Taylor & Francis Online Sep 22 2021 Ophthalmology
  
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