1. Articles in category: Ophthalmology

    1-24 of 5954 1 2 3 4 ... 246 247 248 »
    1. Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

      Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

      Purpose To evaluate the effect of optic nerve head drusen (ONHD) on the retinal nerve fiber layer (RNFL) and macular ganglion cell–inner plexiform layer (GCIPL) using Cirrus optical coherence tomography (OCT). Methods Fifty-seven eyes of thirty patients with ONHD and thirty-eight eyes of twenty age-matched and sex-matched control subjects underwent circumpapillary and macular scanning using Cirrus OCT. The percentages of eyes with abnormal GCIPL and RNFL values according to the Cirrus normative data were analysed and compared. Results Overall, eyes with ONHD showed abnormally reduced values for average and minimum GCIPL thicknesses in 35 % and 45 % of cases compared ...

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    2. Retinal vessel diameter measurements by spectral domain optical coherence tomography

      Retinal vessel diameter measurements by spectral domain optical coherence tomography

      Purpose To describe a spectral domain optical coherence (OCT)-assisted method of measuring retinal vessel diameters. Methods All Patients with an OCT circle scan centered at the optic nerve head using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels both on IR and spectral domain OCT (SD-OCT). Vessel width and vessel types obtained by IR were documented as ground truth. From OCT, measurements of each vessel, including horizontal vessel contour diameter, vertical vessel contour diameter, horizontal hyperreflective core diameter, and reflectance shadowing width, were ...

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    3. System and method with refractive corrections for controlled placement of a laser beam's focal point

      System and method with refractive corrections for controlled placement of a laser beam's focal point

      A methodology is provided for correcting the placement of a laser beam's focal point. Specifically, this correction is done to compensate for displacements of the focal point that may be caused when implant material (e.g. an Intraocular Lens (IOL)) is positioned on the optical path of the laser beam. The methodology of the present invention then determines a deviation of the laser beam's refracted target position (uncompensated) from its intended target position. A calculation of the deviation includes considerations of the laser beam's wavelength and refractive/diffractive characteristics introduced by the implant material. This deviation is ...

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    4. Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years

      Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years

      Purpose To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma. Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, −14.83 ± 4.50 diopters) using swept-source optical coherence tomography. Scleral and choroidal thicknesses were measured at the fovea and four parafoveal locations 2000 μm from the foveal center. Height of the macular bulge was measured as well. Results During the mean follow-up of 24.8 ± 2.5 months, the scleral thickness significantly decreased at the ...

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    5. SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN LONG-TERM SILICONE OIL-RELATED VISUAL LOSS

      SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN LONG-TERM SILICONE OIL-RELATED VISUAL LOSS

      Purpose: To investigate spectral domain optical coherence tomography findings in long-term silicone oil-related visual loss. Methods: Four symptomatic patients were reviewed 4 years to 9 years after vitrectomy with silicone oil tamponade for macula-on retinal detachment. Three lost vision with oil in situ, with one at the time of oil removal. Eleven control eyes with good vision were included. Patients underwent assessment of best-corrected visual acuity, contrast sensitivity, Farnsworth-Munsell 100 Hue testing, static perimetry, and spectral domain optical coherence tomography imaging of the macula and disk. Results: Long-term best-corrected visual acuity was significantly reduced in affected eyes (range, 0.44-1 ...

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    6. Anterior segment optical coherence tomography measurement after neodymium yttrium aluminum garnet laser capsulotomy

      Anterior segment optical coherence tomography measurement after neodymium yttrium aluminum garnet laser capsulotomy

      Purpose To evaluate changes in anterior chamber depth (ACD) and angle width after Neodymium: yttrium aluminum garnet (Nd: YAG) laser capsulotomy. Design Prospective interventional case series. Methods In a single institution, 43 eyes of 43 consecutive pseudophakic patients with symptomatic posterior capsule opacification (PCO) underwent Nd: YAG laser capsulotomy. Anterior chamber depth and angle width in pseudophakic eyes with posterior capsule opacification were measured with Anterior Segment Optical Coherence Tomography (AS-OCT) before and three days after Nd:YAG laser capsulotomy. Pre-operative and post-operative measurements of anterior chamber depth and angle width included the angle opening distance, measured as the perpendicular ...

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    7. Three-dimensional automated choroidal volume assessment on standard spectral-domain optical coherence tomography and correlation with the level of diabetic macular edema

      Three-dimensional automated choroidal volume assessment on standard spectral-domain optical coherence tomography and correlation with the level of diabetic macular edema

      Purpose To measure choroidal thickness on spectral-domain optical coherence tomography (SD-OCT) images using automated algorithms and to correlate choroidal pathology with retinal changes due to diabetic macular edema (DME). Design Post-hoc analysis of multicenter clinical trial baseline data. Methods SD-OCT raster scans/fluorescein angiograms were obtained from 284 treatment naïve eyes of 142 patients with clinically significant DME and from 20 controls. Three-dimensional (3D) SD-OCT images were evaluated by a certified independent reading center analyzing retinal changes associated with diabetic retinopathy. Choroidal thicknesses were analyzed using a fully automated algorithm. Angiograms were assessed manually. Multiple endpoint correction according to ...

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    8. Wound Healing Process After Corneal Stromal Thinning Observed With Anterior Segment Optical Coherence Tomography

      Wound Healing Process After Corneal Stromal Thinning Observed With Anterior Segment Optical Coherence Tomography

      Purpose: The aim of this study was to observe the wound healing process after corneal stromal thinning by using anterior segment optical coherence tomography (AS-OCT) and a slit lamp. Methods: Four patients with corneal stromal thinning (2 patients: corneal iron foreign bodies; 2 patients: keratitis) were included. Serial AS-OCT and slit-lamp examinations were used to follow up the progress of these patients. The thicknesses of the whole cornea and the corneal stroma were measured with AS-OCT and compared with the findings observed during the slit-lamp examination. Results: AS-OCT showed that epithelial hypertrophy and hyperplasia initially occurred in the area of ...

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    9. Evaluation of the Macular Choroidal Thickness Using Spectral Optical Coherence Tomography in Pseudoexfoliation Glaucoma

      Evaluation of the Macular Choroidal Thickness Using Spectral Optical Coherence Tomography in Pseudoexfoliation Glaucoma

      Purpose: To evaluate the choroidal thickness (CT) in pseudoexfoliative (PEX) glaucoma and age-matched healthy subjects using spectral optical coherence tomography (SD-OCT). Patients and Methods: In this prospective study, 32 eyes of 32 PEX glaucoma patients and 30 eyes of 30 age-matched healthy subjects were enrolled. The CT is measured perpendicularly (from the outer edge of the hyperreflective retinal pigment epithelium to the inner sclera) at the fovea, and 1.5 mm temporal, 3.0 mm temporal, 1.5 mm nasal, and 3.0 mm nasal to the fovea using SD-OCT (RTVue-100). Results: The groups were similar regarding the mean age ...

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    10. SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-GUIDED LASER TREATMENT OF CENTRAL SEROUS CHORIORETINOPATHY IN A PREGNANT WOMAN

      SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-GUIDED LASER TREATMENT OF CENTRAL SEROUS CHORIORETINOPATHY IN A PREGNANT WOMAN

      Purpose: To report a case of central serous chorioretinopathy treated with focal laser photocoagulation guided by spectral domain optical coherence tomography (SD-OCT) without fluorescein angiography. Methods: In this interventional case report, a 27-year-old pregnant lady with central serous chorioretinopathy was evaluated with fundus photography and SD-OCT. She was treated with focal laser photocoagulation to the area of micro rip on the summit of pigment epithelial detachment identified by SD-OCT. Results: Successful treatment of serous macular detachment using SD-OCT in a pregnant lady. Conclusion: We report a case of central serous chorioretinopathy evaluated and treated successfully with SD-OCT without the use ...

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    11. Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome

      Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome

      Background The study aims to investigate whether retinal nerve fibre layer (RNFL) abnormalities can be detected in patients with obstructive sleep apnoea/hypopnoea syndrome with normally appearing optic disc. Design This is an observational case-control study. Participants One hundred and eight consecutive patients with moderate or severe obstructive sleep apnoea/hypopnoea syndrome (OSAHS) as determined by overnight polysomnography and normal looking discs and 108 age-matched healthy controls were included in the study. Methods All patients underwent RNFL examinations by optical coherence tomography using fast retinal nerve fibre layer thickness scan. Main Outcome Measures The main outcome measure was RNFL thickness ...

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    12. Biometry of Anterior Segment of Human Eye on Both Horizontal and Vertical Meridians during Accommodation Imaged with Extended Scan Depth Optical Coherence Tomography

      Biometry of Anterior Segment of Human Eye on Both Horizontal and Vertical Meridians during Accommodation Imaged with Extended Scan Depth Optical Coherence Tomography

      Purpose To determine the biometry of anterior segment dimensions of the human eye on both horizontal and vertical meridians with extended scan depth optical coherence tomography (OCT) during accommodation. Methods Twenty pre-presbyopic volunteers, aged between 24 and 30, were recruited. The ocular anterior segment of each subject was imaged using an extended scan depth OCT under non- and 3.0 diopters (D) of accommodative demands on both horizontal and vertical meridians. All the images were analyzed to yield the following parameters: pupil diameter (PD), anterior chamber depth (ACD), anterior and posterior surface curvatures of the crystalline lens (ASC and PSC ...

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    13. Early axonal damage detection by ganglion cell complex analysis with optical coherence tomography in nonarteritic anterior ischaemic optic neuropathy

      Early axonal damage detection by ganglion cell complex analysis with optical coherence tomography in nonarteritic anterior ischaemic optic neuropathy

      Purpose To investigate the ability of ganglion cell complex (GCC) analysis by optical coherence tomography (OCT) to detect early axonal damage in nonarteritic anterior ischaemic optic neuropathy (NAION), and to assess the relationship of GCC measurements with visual field defects and function parameters. Methods Twenty-two patients with NAION participated in this retrospective case-series study. Patients underwent spectral-domain OCT measurement of retinal nerve fibre layer (RNFL) and GCC average and minimum thicknesses, best-corrected visual acuity, Ishihara test and Humphrey visual field (SITA Standard 24–2). These measurements were recorded in the acute (2–6 weeks after the ischaemic episode) and chronic ...

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    14. Influence of Pseudophakic Lens Capsule Opacification on Spectral Domain and Time Domain Optical Coherence Tomography Image Quality

      Influence of Pseudophakic Lens Capsule Opacification on Spectral Domain and Time Domain Optical Coherence Tomography Image Quality

      Purpose : To evaluate the influence of posterior capsule opacification (PCO) on optical coherence tomography (OCT) acquisition of macular retinal thickness (RT) and volume using time domain OCT (TD-OCT) and spectral domain OCT (SD-OCT). Materials and methods : We studied 37 eyes of 31 patients with PCO. Each patient underwent an evaluation with TD-OCT and with SD-OCT before and after Nd:YAG capsulotomy. We recorded RT and retinal volume in the macular area using only good quality images . Results : Best corrected visual acuity improved in all eyes after Nd:YAG capsulotomy, with the degree of improvement ranging from 0.3 ±   0.7 ...

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    15. Automated volumetric analysis of interface fluid in Descemet stripping automated endothelial keratoplasty utilizing intraoperative optical coherence tomography

      Automated volumetric analysis of interface fluid in Descemet stripping automated endothelial keratoplasty utilizing intraoperative optical coherence tomography

      Purpose: To demonstrate a novel automated algorithm for segmentation of intraoperative optical coherence tomography (iOCT) imaging of fluid interface gap in Descemet stripping automated endothelial keratoplasty (DSAEK) and to evaluate the effect of intraoperative maneuvers to promote graft apposition on interface dimensions. Methods: 30 eyes of 29 patients from the anterior segment arm of the PIONEER study were included in this analysis. iOCT scans were entered into an automated algorithm which delineated the spatial extent of the fluid interface gap in three dimensions between donor and host cornea during surgery. The algorithm was validated against manual segmentation and performance was ...

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    16. CHOROIDAL GRANULOMAS VISUALIZED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      CHOROIDAL GRANULOMAS VISUALIZED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To assess the visualization of choroidal granulomas (CG) by enhanced depth imaging optical coherence tomography (EDI-OCT) and to describe their EDI-OCT characteristics. Methods: Combined indocyanine green (ICG) angiography and EDI-OCT images of 44 CG (sarcoid, tubercular, or Vogt-Koyanagi-Harada related) were reviewed. By ICG angiography, CG were classified as full thickness or partial thickness and as small or large. Two independent operators evaluated EDI-OCT scans over granulomas to record their characteristics (full thickness/partial thickness, shape, reflectivity, internal pattern, margins, and shadowing/increased transmission effect). The agreement between ICG angiography and EDI-OCT, the interobserver agreement, and the correlations between EDI-OCT ...

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    17. ENHANCED DEPTH IMAGING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY VERSUS ULTRASONOGRAPHY B-SCAN FOR MEASURING RETINOCHOROIDAL THICKNESS IN NORMAL EYES

      ENHANCED DEPTH IMAGING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY VERSUS ULTRASONOGRAPHY B-SCAN FOR MEASURING RETINOCHOROIDAL THICKNESS IN NORMAL EYES

      Purpose: To assess the accuracy of retinochoroidal thickness measurements obtained by ultrasonography (USG) B-Scan (over eyelids) and high-resolution immersion USG (with lids open) compared with enhanced depth imaging optical coherence tomography (EDI-OCT) in normal subjects. Methods: Retinochoroidal thickness measurements were performed in normal subjects using USG over eyelids and high-resolution immersion USG (with lids open) using the 20-MHz probe keeping EDI-OCT as the gold standard. Mean retinochoroidal thickness at the fovea, 1.5 mm nasally and temporally were analyzed for interobserver agreement using intraclass correlation coefficient test. Paired t-test was used to compare the values obtained by the three techniques ...

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      Mentions: Amod Gupta
    18. System for the improved imaging of eye structures

      System for the improved imaging of eye structures

      A system for the improved imaging of eye structures based on optical coherence tomography. The system includes an interferometric measuring arrangement, which has an optical element arranged in the measurement arm or reference arm for influencing the polarization state of the light before the light is interferometrically superimposed, a scanning unit arranged in the measurement arm for implementing OCT scans, a detector for recording the produced interference pattern, and an evaluating and documenting unit. At least two different polarization states of the light are produced. The interference patterns produced in the interferometric measuring arrangement are recorded and forwarded to the ...

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    19. Ophthalmic tomographic imager with corneo-retinal image analysis

      Ophthalmic tomographic imager with corneo-retinal image analysis

      An optical image measuring device 1 splits low-coherence light L0 into signal light LS and reference light LR, and splits an optical path of the reference light LR into two optical paths having different optical path lengths to split the reference light LR into two reference lights LRa, LRb. Furthermore, the optical image measuring device 1 makes the reference lights LRa, LRb interfere with the signal light LS propagated through an eye E, generates an interference light LC reflecting a morphology in each of two depth positions (fundus oculi Ef and cornea Ec) of an eye E, and detects the ...

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    20. University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      University of Pittsburgh Receives a 2014 NIH Grant for $726,299 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2000 and ends in 2019. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of utmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project is to precisely ...

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    21. Cleveland Clinic / CWRU NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic / CWRU NIH Grant for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic/ Case Western Reserve University Receiver 2014 NIH Grant for $203,124 for Intraoperative Optical Coherence Tomography for Ophthalmic Surgery. The principal investigator is Justis Ehlers. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Optical coherence tomography (OCT) has revolutionized the management of ophthalmic diseases with the precise anatomic information it provides with non-invasive imaging. The high-resolution cross-sectional tissue details make OCT a natural complement to ophthalmic surgery. Intraoperative OCT (iOCT) has the potential to provide real-time feedback to surgeons thus improving surgical care and outcomes. This research activity will ...

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    22. Spectral-domain optical coherence tomography features preceding new-onset neovascular membrane formation

      Spectral-domain optical coherence tomography features preceding new-onset neovascular membrane formation

      Objective To determine the frequency and characteristic spectral-domain optical coherence tomography (SD-OCT) features preceding new-onset choroidal neovascularization (CNV) in the fellow eye of neovascular age-related macular degeneration (AMD) with SD-OCT. Design A prospective, observational study. Participants Sixty-eight fellow eyes of patients with unilateral CNV. Methods SD-OCT was performed at baseline and then monthly. The main outcome measure is the description of retinal morphology 1 month before new onset of neovascularization. Results During the 48-month observation period, new-onset CNV was observed in 27 fellow eyes. Several morphologic features characterized SD-OCT images ≥1 months before new onset of CNV. These included new ...

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    23. OPTICAL COHERENCE TOMOGRAPHIC REFLECTIVITY OF CYSTOID SPACES IS RELATED TO RECURRENT DIABETIC MACULAR EDEMA AFTER TRIAMCINOLONE

      OPTICAL COHERENCE TOMOGRAPHIC REFLECTIVITY OF CYSTOID SPACES IS RELATED TO RECURRENT DIABETIC MACULAR EDEMA AFTER TRIAMCINOLONE

      Purpose: To determine the association between reflectivity levels in foveal cystoid spaces on optical coherence tomography images and the course of the logarithm of the minimum angle of resolution (logMAR) after triamcinolone acetonide treatment for diabetic macular edema. Methods: We retrospectively reviewed 58 consecutive eyes treated with an intravitreal or sub-Tenon's injection of triamcinolone acetonide for diabetic macular edema. The foveal cystoid spaces within central 1 mm were circumscribed, followed by measurement of optical coherence tomography reflectivity. The correlation between the reflectivity and visual outcome was investigated. Results: The optical coherence tomography reflectivity levels in foveal cystoid spaces increased ...

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    1. (4 articles) Medical University of Vienna
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