1. Articles in category: Ophthalmology

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    1. Postdoctoral Position in Advanced Ophthalmic imaging at Johns Hopkins

      Postdoctoral Position in Advanced Ophthalmic imaging at Johns Hopkins

      Description : The Yi and Johnson labs at the Johns Hopkins Wilmer Eye Institute and Dept of Biomedical Engineering are seeking candidates for one fully-funded postdoctoral position focused on developing multimodal 3D retinal imaging . The retina is the visual sensory organ and perceives >80% of information about the world around us. Retinal and optic nerve pathologies, such as glaucoma, can cause severe vision loss and blindness. Optical retinal imaging is particularly valuable in enabling high resolution rendering of 3D anatomical structures and functions using light, and thus plays important translational and clinical roles in evaluating and treating retinal disease. As an ...

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    2. Repeatability and Agreement of Two Swept-Source Optical Coherence Tomographers for Anterior Segment Parameter Measurements

      Repeatability and Agreement of Two Swept-Source Optical Coherence Tomographers for Anterior Segment Parameter Measurements

      Purpose: The aim was to evaluate the repeatability and agreement of two swept-source optical coherence tomographers for anterior segment parameters in healthy subjects. Patients and methods: Automated mark of scleral spur and angle recess for the CASIA2 and manual mark of scleral spur and angle recess for the Anterion were performed, and then the measurement values of the related parameters were automatically generated. Subjects with pupil diameter (PD) differing by <15% between the 2 devices were included. PD, lens vault (LV), anterior chamber depth (ACD), angle to angle distance (ATA), anterior chamber width (ACW), anterior chamber angle (ACA), angle opening ...

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    3. The Role of OCT Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis

      The Role of OCT Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis

      Background and objectives: Recent studies have suggested that inter-eye differences (IEDs) in peripapillary retinal nerve fiber layer (pRNFL) or ganglion cell+inner plexiform (GCIPL) thickness by spectral-domain optical coherence tomography (SD-OCT) may identify people with a history of unilateral optic neuritis (ON). However, this requires further validation. Machine learning classification may be useful for validating thresholds for OCT IEDs and for examining added utility for visual function tests, such as low-contrast letter acuity (LCLA), in the diagnosis of people with multiple sclerosis (PwMS) and for unilateral ON history. Methods: Participants were from 11 sites within the International Multiple Sclerosis Visual ...

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    4. Ray Tracing versus Thin-Lens Formulas for IOL Power Calculation Using Swept-Source Optical Coherence Tomography Biometry

      Ray Tracing versus Thin-Lens Formulas for IOL Power Calculation Using Swept-Source Optical Coherence Tomography Biometry

      Purpose: To evaluate the ray tracing method's accuracy employing Okulix ray tracing software and thin-lens formulas to calculate intraocular lens (IOL) power using a swept-source optical coherence tomography (SS-OCT) biometer (OA2000). Methods: A total of 188 eyes from 180 patients were included in this study. An OA-2000 optical biometer was used to collect biometric data. The predicted postoperative refraction based on thin-lens formulas including SRK/T, Hoffer Q, Holladay 1, and Haigis formulas and the ray tracing method utilizing the OKULIX software was determined for each patient. To compare the accuracy of approaches, the prediction error and the absolute ...

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    5. Asymptomatic Unilateral Full-Thickness Macular Hole in a Patient with Bietti Crystalline Dystrophy During 13-Year Follow-up with Optical Coherence Tomography

      Asymptomatic Unilateral Full-Thickness Macular Hole in a Patient with Bietti Crystalline Dystrophy During 13-Year Follow-up with Optical Coherence Tomography

      A 39-year-old woman with progressive bilateral visual decline was diagnosed as having Bietti crystalline dystrophy in 2008. The disease course was monitored with optical coherence tomography until 2021. During the last routine eye examination in 2021, a full-thickness, slightly eccentric, visually asymptomatic macular hole with an intact foveola was noted in the left eye. No surgical treatment was recommended. The pathogenesis of full-thickness macular hole remained unclear as there were only subtle signs of prior very mild macular edema and vitreomacular interface abnormality. A degenerative process was also possible.

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    6. Optical coherence tomography angiography of conjunctival and episcleral vessels in carotid cavernous fistula

      Optical coherence tomography angiography of conjunctival and episcleral vessels in carotid cavernous fistula

      A 44-year-old man, who had craniofacial trauma due to a motorcycle accident 1 month ago and cerebral arteriography that revealed a right carotid-cavernous fistula, presented with unilateral proptosis and diplopia. On ocular examination, the best-corrected visual acuity was 20/20 in both eyes. In the right eye, examination revealed restricted ocular motility, mild ptosis, 2-mm proptosis, dilation of the conjunctival and episcleral vessels in a medusa’s head ( Fig. 1A ). Intraocular pressure was 30 mmHg in the right eye. Dilated fundus examination showed dilated retinal veins but no venous stasis retinopathy, intraretinal hemorrhages, central retinal vein occlusion, choroidal folds, choroidal ...

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    7. Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters

      Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters

      Cerebral hypoxia is a serious consequence of several cardiorespiratory illnesses. Measuring the retinal microvasculature at high altitude provides a surrogate for cerebral microvasculature, offering potential insight into cerebral hypoxia in critical illness. Additionally, while sex-specific differences in cardiovascular diseases are strongly supported, few have focused on differences in ocular blood flow. We evaluated the retinal microvasculature in males (n=11) and females (n=7) using functional optical coherence tomography at baseline (1,130m) (Day 0), following rapid ascent (Day 2) and prolonged exposure (Day 9) to high altitude (3,800m). Retinal vascular perfusion density (rVPD; an index of total blood ...

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    8. Agreement Between Two Swept-source Optical Coherence Tomography Biometers and A Partial Coherence Interferometer

      Agreement Between Two Swept-source Optical Coherence Tomography Biometers and A Partial Coherence Interferometer

      Purpose To evaluate the level of agreement between ANTERION (Heidelberg Engineering, Heidelberg, Germany), OA-2000 (Tomey, Nagoya, Japan), and IOL Master 500 (Carl Zeiss Meditec AG, Jena, Germany). Methods Fifty-one eyes of 51 patients were included in the study. Flat and steep keratometry (K), vector component of astigmatism (J0 and J45), anterior chamber depth (ACD), and axial length (AL) were compared using the three devices. Repeated-measures analysis of variance was conducted to compare the mean values of the biometrics. Pearson’s correlation test was conducted to analyze the correlations of the measured values, and a Bland–Altman plot was used to ...

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    9. Volume Rendering of Deep Retinal Age-Related Microvascular Anomalies

      Volume Rendering of Deep Retinal Age-Related Microvascular Anomalies

      Purpose To characterize and distinguish non-neovascular deep retinal age-related microvascular anomalies (DRAMA) from type 3 macular neovascularization (MNV) using volume rendering of optical coherence tomography (OCT) and OCT angiography (OCTA). Design Retrospective, consecutive case series. Subjects Consecutive patients with age-related macular degeneration (AMD) exhibiting de novo non-neovascular abnormalities within the deep vascular plexus (DCP) on high-resolution (High-Res) spectral domain and swept-source OCT/OCTA. Patients with retinal vascular alterations attributable to other disease entities were excluded. Methods Complete ophthalmologic examination and multimodal imaging including confocal fundus photography (CFP), spectral domain OCT (SD-OCT), High-Res SD-OCT and OCTA, and volume-averaged swept-source OCTA (SS-OCTA ...

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    10. Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices

      Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices

      Purpose To evaluate the clinical availability of a multifunctional ocular biometric unit, MR-6000 (Tomey Corporation, Nagoya, Japan), for simultaneous keratometry, tonometry, topography, and pachymetry evaluation, and compare anterior segment measurements with five other devices: autokeratometer (KR-1, Topcon, Tokyo, Japan), Scheimpflug camera (Pentacam HR, Oculus, Wetzlar, Germany), swept-source optical coherence tomography (IOLMaster 700, Carl Zeiss, Oberkochen, Germany), Placido disk scanning-slit topography (Orbscan II, Bausch & Lomb, NY, USA), and noncontact tonometry (FT-1000, Tomey Corporation). Methods Thirty patients (30 eyes) who visited our clinic for cataract surgery were examined using MR-6000 and the other devices. The mean keratometry (Km), central corneal thickness (CCT ...

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    11. Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work

      Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work

      Notal Vision, Inc. reported today that numerous scientific and clinical publications and presentations prove the feasibility and efficacy of their patient-operated, home-based optical coherence tomography (OCT) device. As part of a comprehensive remote monitoring service, which includes a monitoring center and artificial intelligence algorithms for information processing, the Notal Home OCT effectively monitors wet age-related macular degeneration (AMD) treatment between doctor’s office visits. Wet AMD is the leading cause of blindness in people over 50 in the United States. Several treatments have been developed over the last two decades and have proven to be extremely beneficial. However, therapy requires ...

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      Mentions: FDA Notal Vision
    12. Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography

      Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography

      The vascular hypothesis of systemic sclerosis (SSc) would predict microvascular alterations should also affect anatomical regions like ocular microvasculature. The objective of this study was to evaluate retinal and choriocapillary vessel density (VD) in patients with definite SSc and very early disease of systemic sclerosis (VEDOSS) using optical coherence tomography angiography (OCTA). 22 eyes of 22 patients and 22 eyes of 22 healthy subjects were included in this study. Patients were classified into patients with definite SSc and patients with VEDOSS. VD data of the superficial OCT angiogram (OCTA-SCP), deep OCT angiogram (OCTA-DCP) and choriocapillaris (OCTA-CC) were analysed. VD in ...

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      Mentions: Visionix
    13. Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy

      Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy

      This cross-sectional study aimed to quantitatively analyze the optical coherence tomography angiography (OCTA) images using MATLAB-based software and evaluate the initial changes in macular vascular density and the distortion of the foveal avascular zone (FAZ), before the clinical appearance of diabetic retinopathy. For this purpose, 21 diabetic patients without any clinical features indicating DR, and 21 healthy individuals matched with patients based on their demographic characteristics were included. Macular thickness, macular vascular density, and morphological changes of FAZ were assessed using OCTA. The diagnostic ability of morphological parameters was evaluated by receiver operating curve analysis. The intraclass correlation coefficient (ICCC ...

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    14. Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study

      Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study

      Objectives: Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical findings have been reported before. This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT). Design: Prospective single-arm diagnostic accuracy study. Setting: Tertiary care centre (University Eye Clinic). Participants: 46 patients with age-related macular degeneration. Interventions: Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. Additionally, all ...

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    15. Treatment of Descemet's membrane detachment after primary Descemet's stripping automated endothelial keratoplasty during surgery using intraoperative optical coherence tomography

      Treatment of Descemet's membrane detachment after primary Descemet's stripping automated endothelial keratoplasty during surgery using intraoperative optical coherence tomography

      Purpose: To present a novel microscope-integrated optical coherence tomography (iOCT)-guided surgical technique wherein Descemet's membrane detachment (DMD), occurring during vitrectomy, was treated intraoperatively in a patient who had previously undergone Descemet's stripping automated endothelial keratoplasty (DSAEK). Observations: The surgical technique was performed on a 75-year-old man with a history of DSAEK to intraoperatively treat DMD, which occurred during vitrectomy in the left eye. A fine needle mounted on a syringe was inserted into the supra-Descemet's space under iOCT guidance. The location of the needle was easily identified by its high reflection. The interface fluid was safely ...

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      Mentions: Osaka University
    16. Reflectance-Based Structural Quantification of the Healthy and Glaucomatous Retinal Nerve ...

      Reflectance-Based Structural Quantification of the Healthy and Glaucomatous Retinal Nerve ...

      Glaucoma is a group of progressive optic neuropathies that can lead to irreversible vision loss if left untreated. Spectral-domain optical coherence tomography (SD-OCT) is an important imaging tool used in the diagnosis and management of glaucoma. It provides thickness measurements of the retinal nerve fiber layer (RNFL), a useful index for monitoring progressive thinning that occurs from damage. However, there exists high between-subject variability in RNFL thickness in people free of eye disease. Another approach is RNFL reflectance, proposed in 1921 when reduction in reflectance was observed in damaged RNFL. Despite numerous reports from the past century supporting this, clinically ...

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    17. Optical Coherence Tomography Angiography in Chiasmitis

      Optical Coherence Tomography Angiography in Chiasmitis

      A 29-year-old girl presented complaining of acute bilateral visual loss associated with mild headache and retrobulbar pain. She was diagnosed with chiasmal optic neuritis caused by multiple sclerosis. Her visual acuity and visual field defect promptly improved after steroid therapy. However optical coherence tomography angiography showed a progressive reduction of superficial capillary plexus density of the retina and optic nerve consistent with the progressive impairment of the retinal ganglionar cell layer. Contrary to chiasmal compression, in chiasmal optic neuritis, the superficial capillary plexus density reduction is diffuse and does not reflect the peculiar anatomy of the chiasm.

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    18. Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia

      Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia

      Background: Structural ophthalmologic findings have been reported in patients with β-thalassemia due to chronic anemia, iron overload, and iron chelation therapy toxicity in few previous studies. We aimed to investigate structural ocular findings and their relationship with hematological parameters in patients with transfusion-dependent β-thalassemia (TDT). Methods: In this cross-sectional study, from January 2018 to January 2019, 39 patients with TDT over the age of 18 participated. Multicolor fundus imaging, optical coherence tomography (OCT), and blue light fundus autofluorescence imaging were performed for all patients and 27 age- and sex-matched controls. Results: The mean age of patients was 28.6 ± 6 ...

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    19. Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea

      Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea

      Significance: Optical coherence tomography (OCT) allows high-resolution volumetric three-dimensional (3D) imaging of biological tissues in vivo. However, 3D-image acquisition can be time-consuming and often suffers from motion artifacts due to involuntary and physiological movements of the tissue, limiting the reproducibility of quantitative measurements. Aim: To achieve real-time 3D motion compensation for corneal tissue with high accuracy. Approach: We propose an OCT system for volumetric imaging of the cornea, capable of compensating both axial and lateral motion with micron-scale accuracy and millisecond-scale time consumption based on higher-order regression. Specifically, the system first scans three reference B-mode images along the C-axis before ...

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    20. Optical coherence tomography image based eye disease detection using deep convolutional neural network

      Optical coherence tomography image based eye disease detection using deep convolutional neural network

      Over the past few decades, health care industries and medical practitioners faced a lot of obstacles to diagnosing medical-related problems due to inadequate technology and availability of equipment. In the present era, computer science technologies such as IoT, Cloud Computing, Artificial Intelligence and its allied techniques, etc. play a crucial role in the identification of medical diseases, especially in the domain of Ophthalmology. Despite this, ophthalmologists have to perform the various disease diagnosis task manually which is time-consuming and the chances of error are also very high because some of the abnormalities of eye diseases possess the same symptoms. Furthermore ...

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    21. Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants

      Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants

      Purpose: To identify optical coherence tomography (OCT) biomarkers that may predict functional and anatomical outcomes in diabetic macular edema (DME) patients treated with intravitreal dexamethasone (DEX) implant. Materials and methods: Sixty-four eyes from 50 patients with DME were enrolled. Best-corrected visual acuity (BCVA) and OCT biomarkers including central retinal thickness (CRT), subretinal fluid (SRF), intraretinal cysts (IRC), ellipsoid zone disruption (EZD), disorganization of retinal inner layers (DRIL), hard exudate (HE), hyperreflective foci (HRF), epiretinal membrane (ERM), and vitreomacular interface (VMI) changes were evaluated at baseline and at 3, 6, and 12 months after treatment. Multiple logistic analysis was performed to ...

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    22. Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images

      Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images

      The aim of this study was to investigate the characteristics of macular and optic disc parameters in children with amblyopic and nonamblyopic eyes, using fundus images under optical coherence tomography (OCT). 36 patients with anisometropic amblyopia were selected in the experimental group, and another 36 healthy volunteers were selected in the control group, OCT examinations were performed in all groups, and the mean diopter, mean corrected visual acuity (CVA), mean axial length, mean optic disc retinal nerve fiber layer (RNFL) thickness, and mean macular fovea thickness were recorded in the two groups. The results found that the average diopter of ...

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    23. Optical coherence tomography assessment of the enamel surface after debonding the ceramic brackets using three different techniques

      Optical coherence tomography assessment of the enamel surface after debonding the ceramic brackets using three different techniques

      Objective: To assess the enamel surface damage and residual adhesive remnant [adhesive remnant index (ARI)] on extracted premolars after debonding the ceramic brackets using three different debonding techniques, with optical coherence tomography (OCT). Methods: Ninety extracted premolars were bonded with ceramic brackets and divided into three groups of 30 teeth each based on debonding techniques used. Twenty-four hours later, they were debonded using three different debonding techniques: debonding pliers, ultrasonic scalers, and Er-YAG laser. A baseline scan was obtained prior to bonding using OCT. The teeth were evaluated for the adhesive remnant on the tooth surface using ARI score, and ...

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