1. Articles in category: Ophthalmology

    1-24 of 5902 1 2 3 4 ... 244 245 246 »
    1. Anterior segment optical coherence tomography in acute anterior uveitis

      Anterior segment optical coherence tomography in acute anterior uveitis

      Purpose: To analyze the corneal thickness and anterior chamber (AC) angle using anterior segment optical coherence tomography (AS-OCT) in patients with acute anterior uveitis (AAU). Methods: Twenty two patients (24 eyes) were included. All patients underwent complete ophthalmological examination, applanation tonometry and AS-OCT at diagnosis and fifteen days after treatment. Results: Average corneal thickness before treatment was 564.2 ± 44.2 µm, 580.0 ± 44.3 µm and 580.1 ± 2.9 µm, respectively in central, pericentral and paracentral cornea. Fifteen days after treatment a significant decrease of corneal thickness was observed, with 529.5 ± 33.1 µm (p=0 ...

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    2. EFFECT OF RANIBIZUMAB ON HIGH-SPEED INDOCYANINE GREEN ANGIOGRAPHY AND MINIMUM INTENSITY PROJECTION OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

      EFFECT OF RANIBIZUMAB ON HIGH-SPEED INDOCYANINE GREEN ANGIOGRAPHY AND MINIMUM INTENSITY PROJECTION OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

      Purpose: The purpose of this 1-year prospective study was to investigate how induction/pro re nata ranibizumab intravitreal treatment of eyes with neovascular age-related macular degeneration affects the anatomy of choroidal neovascularization (CNV) and the overlying outer retinal tissue. Methods: High-speed indocyanine green (HS-ICG) angiography measurements provided quantification of the CNV size in 60 patients followed for 1 year. Minimum intensity projection optical coherence tomography (MinIP OCT), a novel algorithm assessing minimum optical intensity between the internal limiting membrane and retinal pigment epithelium, measured the area of outer retinal disruption overlying the CNV. Fluorescein angiography was also assessed to evaluate ...

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    3. MACULAR AND PERIPAPILLARY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHANGES IN SICKLE CELL RETINOPATHY

      MACULAR AND PERIPAPILLARY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHANGES IN SICKLE CELL RETINOPATHY

      Purpose: To assess peripapillary retinal nerve fiber layer, macular ganglion cell complex, and total macular thicknesses using spectral domain optical coherence tomography on sickle cell disease patients with and without sickle retinopathy. Method: Nineteen eyes of 11 patients with hemoglobin sickle cell disease, 65 eyes of 36 patients with hemoglobin SS disease, and 48 eyes of 24 healthy subjects underwent spectral domain optical coherence tomography scanning (RTVue). Eyes of patients with sickle cell disease were classified into 3 groups according to posterior segment changes: no retinopathy (n = 64), nonproliferative retinopathy (n = 12), and proliferative retinopathy (n = 8). Results: The central ...

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    4. Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Purpose: Evaluation of bleb morphology using anterior segment optical coherence tomography (OCT) can offer important information regarding bleb function after glaucoma surgery. However, analysis of tissue properties, such as scar fibrosis of blebs, is difficult with conventional OCT. The birefringence of the blebs as susceptible measure of fibrosis scar was evaluated using polarization-sensitive OCT (PS-OCT) and its relation with bleb function was assessed. Methods: One hundred and fifty-three blebs of 122 patients that had undergone trabeculectomy or an Ex-Press tube shunt were examined. Also, in 14 blebs of 12 patients, consecutive measurements were performed for 2 months after surgery. The ...

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    5. Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration

      Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration

      Purpose: Previously, we have shown that age-related macular degeneration (AMD) influences glaucoma classification with the ganglion cell complex (GCC) parameters of the RTVue-100 optical coherence tomograph (RTVue-OCT) in nonglaucomatous eyes. Now, we reevaluated the influence of AMD on GCC image segmentation and classification for glaucoma on the same eyes, using a new version of the software. Methods: GCC images of nonglaucomatous eyes [30 healthy, 19 with early/intermediate AMD, 16 with subfoveal choroidal neovascularization (CNV), and 19 after intravitreal antiangiogenic treatment of CNV, CNV-anti-VEGF] were reanalyzed with software versions 6.3 (the currently available version) and 6.12 (a version ...

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    6. Automatic tracking of pupillary dynamics from in vivo functional optical coherence tomography images

      Automatic tracking of pupillary dynamics from in vivo functional optical coherence tomography images

      A major challenge currently faced in measuring visually evoked optical changes in different retinal layers using in vivo and non-invasive functional optical coherence tomography (fOCT) is the need for pupillary dilation drugs to enable reliable measurement of the retinal functional responses. However, there are situations where the use of pupillary dilation drugs is not suitable in both clinical and animal ophthalmic research situations. To overcome this challenge, we propose a new approach to tracking visually evoked pupillary dynamics, based on the use of a fast scanning fOCT system and a novel computerised framework, which can then be used to isolate ...

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    7. Choroidal vessel characterization using en-face optical coherence tomography measurement

      Choroidal vessel characterization using en-face optical coherence tomography measurement

      The choroid plays an important role in the pathogenesis of many diseases of the back section of the eye. A comprehensive visualization and knowledge of the choroid is still lacking despite advances in imaging technologies. En-face Optical Coherence Tomography (OCT) provides detailed images useful to understand choroidal vasculature. In the paper, in order to get essential information about circulation-related ocular diseases, an image processing and measurement procedure is presented, capable of providing an efficient choroidal vessel segmentation and caliber estimation starting from en-face OCT images.

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    8. Preoperative Progression of Macular Holes

      Preoperative Progression of Macular Holes

      Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre- optical coherence tomography era. By observing macular holes preoperatively we are able to determine the extent of the preoperative macular hole progression. At our institution macular holes are treated in an elective setting. The majority of macular holes undergo a 2-step sequence of phacoemulsification and intraocular lens implantation followed by vitrectomy. We wish to observe the effect of time and cataract surgery on the progression of macular holes prior to vitrectomy.

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    9. Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease - Schneider - 2014 - Movement Disorders - Wiley Online Library

      Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease - Schneider - 2014 - Movement Disorders - Wiley Online Library

      Background Optical coherence tomography (OCT) is a noninvasive procedure for analysis of retinal morphology. Significant changes in the thickness of the peripapillary retinal nerve fiber layer (RNFL) in Parkinson's disease (PD) have been reported, and the current study was performed to examine whether such changes can also be detected in an animal model of PD. Methods Optical coherence tomography measurements of peripapillary RNFL thickness, macula volume, and foveal thickness were obtained from 10 normal and five 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated cynomolgus monkeys with stable Parkinsonian signs. Results Average RNFL thickness was significantly decreased in Parkinsonian monkeys compared ...

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    10. The Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy (PIONEER) Study: 2-year Results

      The Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy (PIONEER) Study: 2-year Results

      Purpose To evaluate the feasibility, safety, and utility of intraoperative optical coherence tomography (OCT) for use during ophthalmic surgery. Design Prospective, consecutive, case series Methods A prospective, single-center, consecutive, case series was initiated to assess intraoperative OCT in ophthalmic surgery. Intraoperative scanning was performed with a microscope mounted spectral domain OCT system. Disease specific or procedure-specific imaging protocols (e.g., scan type, pattern, size, orientation, density) were utilized for anterior and posterior segment applications. A surgeon feedback form was recorded as part of the study protocol to answer specific questions regarding intraoperative OCT utility immediately after the surgical procedure was ...

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    11. Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      The aim of this study was to compare the central and peripheral pachymetric measurements determined with Sirius system and Visante OCT and evaluate the agreement between them at different stages of keratoconus. Measurements were not significantly different in all patients and subgroups and showed high correlation for the corneal thicknesses of the entire cornea in different stages of keratoconus.

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    12. Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) are cross-sectional, noncontact, highresolution diagnostic modalities for posterior and anterior segment (AS) imaging.The AS-OCT provides tomographic imaging of the cornea, iris, lens, and anterior chamber (AC) angle in several ophthalmic diseases. In glaucoma, AS-OCT is utilized to evaluate the morphology of AS structures involved in the pathogenesis of the disease, to obtain morphometric measures of the AC, to evaluate the suitability for laser or surgical approaches, and to assess modifications after treatment. In patients undergoing surgery, AS-OCT is crucial in the evaluation of the filtering bleb functionality, permitting ...

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    13. OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      Purpose: To demonstrate the ability to monitor geographic atrophy (GA) volumetrically through all retinal layers with high-resolution optical coherence tomography difference maps and average macular volume. Methods: Observational case report. Results: Two patients diagnosed with GA were followed up for multiple years with consecutive high-resolution optical coherence tomography studies along with fundus photography and fluorescein angiography or fundus autofluorescence. Difference maps visually reflect macular thinning associated with expansion of GA witnessed on alternative studies. In addition, these maps show progressive macular thinning within previously delineated areas of GA. Average macular volume quantitatively demonstrates the decreasing volume associated with the expanding ...

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    14. Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Importance Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings. Objective To evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain (SD) (Cirrus; Carl Zeiss Meditec, and Spectralis; Heidelberg Engineering) instruments and formulate equations to convert retinal thickness measurements from SD-OCT to equivalent values on TD-OCT. Design, Setting, and Participants A cross-sectional observational study was conducted in private and institutional practices. Persons with diabetes mellitus who had at least 1 eye with central-involved diabetic macular ...

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    15. A FALSE COLOR FUSION STRATEGY FOR DRUSEN AND GEOGRAPHIC ATROPHY VISUALIZATION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES

      A FALSE COLOR FUSION STRATEGY FOR DRUSEN AND GEOGRAPHIC ATROPHY VISUALIZATION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES

      Purpose: To display drusen and geographic atrophy (GA) in a single projection image from three-dimensional spectral domain optical coherence tomography images based on a novel false color fusion strategy. Methods: We present a false color fusion strategy to combine drusen and GA projection images. The drusen projection image is generated with a restricted summed-voxel projection (axial sum of the reflectivity values in a spectral domain optical coherence tomography cube, limited to the region where drusen is present). The GA projection image is generated by incorporating two GA characteristics: bright choroid and thin retina pigment epithelium. The false color fusion method ...

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    16. DISTRIBUTION OF INTRARETINAL EXUDATES IN DIABETIC MACULAR EDEMA DURING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OBSERVED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FUNDUS PHOTOGRAPHY

      DISTRIBUTION OF INTRARETINAL EXUDATES IN DIABETIC MACULAR EDEMA DURING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OBSERVED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FUNDUS PHOTOGRAPHY

      Purpose: To evaluate changes in the distribution and morphology of intraretinal microexudates and hard exudates (HEs) during intravitreal anti-vascular endothelial growth factor therapy in patients with persistent diabetic macular edema. Methods: Twenty-four patients with persistent diabetic macular edema after photocoagulation were investigated in this prospective cohort study. Each eye was assigned to a loading dose of three anti-vascular endothelial growth factor treatments at monthly intervals. Additional single treatments were performed if diabetic macular edema persisted or recurred. Intraretinal exudates were analyzed over 6 months using spectral domain optical coherence tomography (SD-OCT) and fundus photography. Results: Before treatment, microexudates were detected ...

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    17. Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas

      Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas

      Purpose To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or Neurofibromatosis type 1 (NF1). Design Prospective longitudinal cohort study Methods Children with sporadic optic pathway gliomas and/or NF1 who had ≥ 2 volumes acquired over the macula using handheld OCT during sedation for a clinically indicated MRI were eligible for the intra-visit cohort. Children with repeat handheld OCT imaging within 6 months were eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using ...

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    18. Astronaut Using Optical Coherence Tomography during an Ocular Health vision Test on the International Space Station

      Astronaut Using Optical Coherence Tomography during an Ocular Health vision Test on the International Space Station

      Flight Engineer Alexander Gerst uses the Optical Coherence Tomography camera during an Ocular Health vision test in the Harmony node of the International Space Station. Commander Steve Swanson (left) assists Gerst. Image credit: NASA. Larger image (1 MB): http://www.nasa.gov/sites/default/files/oh_vision_test.jpg

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    19. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Purpose: To investigate exudative macular disease, multi-functional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. Methods: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm 2 around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA) and cumulative phase retardation images were obtained ...

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    20. Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Purpose:To compare Subfoveal Choroidal Thickness (SFCT) before and after unenventful cataract surgery using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT). Methods:A prospective study was conducted on 115 eyes of 95 patients who had phacoemulsification. Measurements of SFCT were performed preoperatively and one day (D1), seven days (D7), one month (M1) and three months (M3) after surgery using the EDI OCT technique. Central Retinal Thickness (CRT) was measured before surgery and at M1 and M3. Results:The 95 patients had a mean age of 76±8.3 years. The mean SFCT at baseline was 224±75μm. It ...

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    21. Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Purpose: To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT). Methods: 180 normal subjects (180 healthy eyes) were enrolled and divided into four groups according to age: A (0-20 years), B (21-40 years), C (41-60 years), D (>60 years). Cornea and limbus were imaged with OCT. Corneal ET (CET) was obtained automatically by the built-in analysis software of the OCT system. Limbal ET (LET) in four quadrants was manually measured from OCT images. Results: CET of central 2-mm diameter zone in groups A ...

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    22. Neural Network Analysis of Different Segmentation Strategies of Nerve Fiber Layer Assessment for Glaucoma Diagnosis

      Neural Network Analysis of Different Segmentation Strategies of Nerve Fiber Layer Assessment for Glaucoma Diagnosis

      Purpose: To compare the diagnostic performance of different segmentations of the nerve fiber layer (NFL) thickness measurements using an artificial neural network and to define the optimal number of sectors with best diagnostic ability for glaucoma diagnosis. Methods: A total of 117 glaucoma patients and 123 normal subjects were included in the study. NFL thickness measurements were performed using the Spectralis-OCT (Heidelberg Engineering) to obtain the NFL thickness average; measurements from 2 semicircles, 4 quadrants, and 6, 8, 12, 16, 24, 32, and 64 sectors; and 768 uniformly divided locations around the peripapillary NFL. An artificial neural network evaluation was ...

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    23. Association Between Transient Interface Fluid on Intraoperative OCT and Textural Interface Opacity After DSAEK Surgery in the PIONEER Study

      Association Between Transient Interface Fluid on Intraoperative OCT and Textural Interface Opacity After DSAEK Surgery in the PIONEER Study

      Purpose: The aim of this study was to examine the association between transient interface fluid (TIF) and textural interface opacity (TIO) after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery using intraoperative optical coherence tomography (iOCT) in the PIONEER (Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy) study. Methods: All consecutive eyes that underwent DSAEK between October 2011 and September 2013 from the PIONEER intraoperative and perioperative OCT study were included. iOCT images were captured after lenticule apposition with complete air fill and after air-fluid exchange. Postoperative day 1 OCT images were obtained. Outcome variables included the presence of ...

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    24. Misguided Progression Analysis by Optical Coherence Tomography: A Report of Two Cases

      Misguided Progression Analysis by Optical Coherence Tomography: A Report of Two Cases

      Spectral domain optical coherence tomography (SOCT) is an important tool for the diagnosis and management of glaucoma. In an effort to help automate the detection of progressive structural glaucomatous optic nerve damage, Carl Zeiss Meditec has developed Guided Progression Analysis (GPA) software in conjunction with the Cirrus SOCT (Carl Zeiss Meditec, Dublin, Calif., USA). Here, we report a case in which the GPA merged information from 2 different patients, and another case in which data from alternate eyes was compared, making the final analysis invalid.

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