1. Articles in category: Ophthalmology

    1-24 of 6234 1 2 3 4 ... 258 259 260 »
    1. Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma

      Diagnostic accuracy of the parameters from ganglion cell  complex map, evaluated with SD-OCT in primary open-angle  glaucoma

      Purpose: To evaluate the sensitivity and specificity of ganglion cell complex (GCC) parameters, obtained with optical coherence tomography (OCT) and to determine their role in diagnosis of primary open-angle glaucoma patients. Materials and methods: The study included 84 eyes of patients with primary open-angle glaucoma (POAG) and 40 eyes of healthy individuals. All of them underwent complete eye examination, including standard automated perimetry (HFA II) and OCT (RTVue-100). Avg. GCC (average GCC), Sup. GCC (superior GCC), Inf. GCC (inferior GCC), GLV (globаl loss volume), FLV (focal loss volume) and RNFL (retinal nerve fiber layer — ONH map) were measured. ROC curves ...

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    2. Intraocular optical coherence tomography

      Intraocular optical coherence tomography

      Since its introduction as a diagnostic instrument, optical coherence tomography (OCT) has become an essential instrument for ophthalmologists as it offers accurate details on both the vitreoretinal interface and the retinal layers. Initially designed as a pre- and post-operative instrument, today we are attending to its introduction as an intraoperative tool. Inspired by the intravascular use of the OCT, we developed a prototype spectral domain OCT probe for intraocular use. It is therefore possible to make dynamic real-time scans from the vitreous and retina at the posterior pole and in the peripheral retina. This type of endo-OCT may therefore help ...

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    3. Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy

      Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy

      Purpose The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA). Methods The study was a retrospective, institutional, and comparative case series. Thirty-six consecutive patients with ADOA and 72 age-matched normal controls were compared with regard to RNFLT, best-corrected visual acuity (BCVA), and visual field. Results The relative reduction of RNFLT of ADOA patients was most evident in the temporal quadrant (56.8 %), followed by the inferior (35.5 %), superior (27.2 %), and nasal quadrants ...

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    4. Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease: a controlled study

      Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease: a controlled study

      Purpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Methods: Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and ...

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    5. Assessment of Corneal Epithelial Thickness in Dry Eye Patients

      Assessment of Corneal Epithelial Thickness in Dry Eye Patients

      Purpose To investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients. Methods In this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology. Several epithelium statistics for each eye, including central, superior, inferior, minimum, maximum, minimum − maximum, and map standard deviation, were averaged. Correlations of epithelial thickness with the symptoms of dry eye were calculated. Results The mean ...

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    6. Optical coherence tomography for an in-vivo study of posterior-capsule-opacification types and their influence on the total-pulse energy required for Nd:YAG Capsulotomy: a case series

      Optical coherence tomography for an in-vivo study of posterior-capsule-opacification types and their influence on the total-pulse energy required for Nd:YAG Capsulotomy: a case series

      Background Posterior capsule opacification (PCO) is the most common post-operative complication associated with cataract surgery and is mostly treated with Nd:YAG laser capsulotomy. Here, we demonstrate the use of high-resolution spectral-domain optical coherence tomography (OCT) as a technique for PCO analysis. Additionally, we evaluate the influence of PCO types and the distance between the intraocular lens (IOL) and the posterior capsule (PC), i.e., the IOL/PC distance, on the total-pulse energy required for the Nd:YAG laser posterior capsulotomy. Methods 47 eyes with PCO scheduled for the Nd:YAG procedure were examined and divided into four categories: fibrosis ...

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    7. Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Purpose To determine the repeatability, reproducibility, and agreement of anterior chamber depth (ACD) measurements obtained with 3 Scheimpflug cameras and an anterior segment optical coherence tomography (AS-OCT) device. Setting Eye Hospital of Wenzhou Medical University, Zhejiang, China. Design Observational cross-sectional study. Methods Two observers took 3 consecutive measurements in healthy right eyes using each device to assess intraoperator repeatability. The mean values obtained at different sessions by the first operator were used to determine the intersession reproducibility. Three consecutive measurements obtained by the first operator at the first session were averaged and used to assess agreement. Results The ACD measurements ...

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    8. Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence

      Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence

      Background : “ Poppers ” is a slang term for a group of alkyl nitrites that are used as recreational drugs . Their inhalative intoxication leads to muscle relaxation, analgesia, and euphoria. Maculopathy is a rare but serious side-effect. Patients/Methods : Clinical, imaging, and electrophysiological findings of seven patients with maculopathy after consumption of poppers were presented. Results : All seven patients were male with a median age of 35 years (range 28–45 years), the median duration of periodical poppers use until the onset of symptoms was 9.8 years (one day to 25 years). Five of seven patients were HIV-positive, one patient was ...

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    9. A New OCT-based Method to Generate Virtual Maps of Vitreomacular Interface Pathologies

      A New OCT-based Method to Generate Virtual Maps  of Vitreomacular Interface Pathologies

      Optical coherence tomography (OCT) is the most accurate modality for noninvasive assessment of vitreoretinal interface (VRI). The scientific objective of research presented in this paper was to develop a new OCT-based method for investigation of vitreomacular interface pathologies in human eyes. We propose a new approach for the automatic generation of virtual maps representing the distance between the posterior surface of the hyaloid (PSH) and the inner limiting membrane (ILM) in the vitreomacular traction (VMT) pathology. Volumetric data was acquired from 3 adult patients with VMT. OCT B-scans were processed frame-by-frame and refined by advanced digital imaging algorithms, including application ...

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    10. Glaucoma Module Premium Edition for SPECTRALIS to be Showcased at Annual Optometric Press Conference

      Glaucoma Module Premium Edition for SPECTRALIS to be Showcased at Annual Optometric Press Conference

      Heidelberg Engineering GmbH, the global ophthalmic imaging company, is presenting the Glaucoma Module Premium Edition for SPECTRALIS at the annual 2014 American Academy of Optometry Professional Press Conference in Denver, CO. The Glaucoma Module Premium Edition for SPECTRALIS* module combines a proprietary technology called Anatomic Positioning System (APS) with a series of unique scan patterns. The APS creates an anatomic map of each eye. The center of the optic nerve head and the fovea are detected via a short pre-scan function. The map is aligned according to these anatomical landmarks, individually for each eye. Subsequent scans are oriented to this ...

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    11. The impact of multifocal intraocular lens in retinal imaging with optical coherence tomography

      The impact of multifocal intraocular lens in retinal imaging with optical coherence tomography

      Multifocal intraocular lenses (MF IOLs) have concentric optical zones with different dioptric power, enabling patients to have good visual acuity at multiple focal points. However, several optical limitations have been attributed to this particular design. The purpose of this study is to access the effect of MF IOLs design on the accuracy of retinal optical coherence tomography (OCT). Cross-sectional study conducted at the Refractive Surgery Department of Central Lisbon Hospital Center. Twenty-three eyes of 15 patients with a diffractive MF IOL and 27 eyes of 15 patients with an aspheric monofocal IOL were included in this study. All patients underwent ...

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    12. Automated detection of choroid boundary and vessels in optical coherence tomography images

      Automated detection of choroid boundary and vessels in optical coherence tomography images

      Structural changes in the choroid, a layer located between the retina and sclera, could indicate various vision impairments. Consequently, ophthalmologists inspect optical coherence tomography (OCT) scans of the posterior section of the eye towards making diagnosis. With a view to assist diagnosis, we propose an automated technique for segmentation of the choroid layer. Specifically, we detect the upper and lower boundaries of the choroid using structural similarity and adaptive Hessian analysis. Subsequently, we detect choroid vessels within those boundaries using a level set method. Experimental results are presented using spectral domain (SD) OCT images.

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    13. A hierarchical framework for estimating neuroretinal rim area using 3D spectral domain optical coherence tomography (SD-OCT) optic nerve head (ONH) images of healthy and glaucoma eyes

      A hierarchical framework for estimating neuroretinal rim area using 3D spectral domain optical coherence tomography (SD-OCT) optic nerve head (ONH) images of healthy and glaucoma eyes

      Glaucoma is a chronic neurodegenerative disease characterized by loss of retinal ganglion cells, resulting in distinctive changes in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL). Important advances in technology for non-invasive imaging of the eye have been made providing quantitative tools to measure structural changes in ONH topography, a crucial step in diagnosing and monitoring glaucoma. 3D spectral domain optical coherence tomography (SD-OCT), an optical imaging technique, has been commonly used to discriminate glaucomatous from healthy subjects. In this paper, we present a new approach for locating the Bruch’s membrane opening BMO and then estimating ...

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    14. Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part II. Correlations and Relationship to Clinical Features

      Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part II. Correlations and Relationship to Clinical Features

      Purpose: The accepted method to evaluate and monitor papilledema, Frisén grading, is an ordinal approach based on descriptive features. Part I showed spectral domain (SD) optical coherence tomography (OCT) in a clinical trial setting provides reliable measurement of the effects of papilledema on the optic nerve head (ONH) and peripapillary retina, particularly if a 3D-segmentation method is used for analysis.1 We evaluated how OCT parameters are interrelated and how they correlate with vision and other clinical features in idiopathic intracranial hypertension (IIH). Methods: 126 subjects in the IIH Treatment Trial (IIHTT) OCT substudy had Cirrus SD-OCT optic disc ...

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    15. State-of-the-Art in Retinal Optical Coherence Tomography Image Analysis

      State-of-the-Art in Retinal Optical Coherence Tomography Image Analysis

      Optical Coherence Tomography (OCT) is one of the most emerging imaging modalities that has been used widely in the eld of biomedical imaging. From its emergence in 1990's, plenty of hardware and software improvements have been made. Its applications range from ophthalmology to dermatology to coronary imaging etc. Here, the focus is on applications of OCT in ophthalmology and retinal imaging. OCT is able to non- invasively produce cross-sectional volume images of the tissues which are further used for analysis of the tissue structure and its properties. Due to the underlying physics, OCT images usually su er from a ...

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    16. Relationship Between Optic Nerve Appearance and Retinal Nerve Fiber Layer Thickness as Explored with Spectral Domain Optical Coherence Tomography

      Relationship Between Optic Nerve Appearance and Retinal Nerve Fiber Layer Thickness as Explored with Spectral Domain Optical Coherence Tomography

      Purpose: To study the relationship between the appearance of the optic nerve and the retinal nerve fiber layer (RNFL) thickness determined by spectral domain optical coherence tomography (OCT). Methods: Records from patients with spectral domain -OCT imaging in a neuro-ophthalmology practice were reviewed. Eyes with glaucoma/glaucoma suspicion, macular/ optic nerve edema, pseudophakia, and with refractive errors > 6D were excluded. Optic nerve appearance by slit lamp biomicroscopy was related to the RNFL thickness by spectral domain -OCT and to visual field results. Results: Ninety-one patients (176 eyes; mean age: 49 ± 15 years) were included. Eighty-three eyes (47%) showed optic nerve ...

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    17. Evaluation of Choroidal Thickness in Amblyopia Using Enhanced Depth Imaging Optical Coherence Tomography

      Evaluation of Choroidal Thickness in Amblyopia Using Enhanced Depth Imaging Optical Coherence Tomography

      Purpose : To evaluate the choroidal thickness (CT) in hyperopic anisometropic amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical coherence tomography (SD-OCT). Materials and methods : In total 53 subjects (17.8 ± 11.0 years, mean ± SD) with hyperopic anisometropic amblyopia (AE) and 53 age-matched controls (17.7 ± 11.0 years) were included in this prospective study. Each subject underwent a dilated eye examination, cycloplegic refraction and axial length (AL) measurement using Nidek AL-Scan optical biometer (Nidek CO, Aichi, Japan). The CT of subfoveal area and at a radius of 1 and 3 mm around the fovea was ...

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    18. COLOCALIZATION OF PSEUDODRUSEN AND SUBRETINAL DRUSENOID DEPOSITS USING HIGH-DENSITY EN FACE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      COLOCALIZATION OF PSEUDODRUSEN AND SUBRETINAL DRUSENOID DEPOSITS USING HIGH-DENSITY EN FACE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To determine if pseudodrusen seen in fundus photography, particularly infrared scanning laser ophthalmoscopy, colocalize with subretinal drusenoid deposits imaged by optical coherence tomography. Methods: The patients were scanned with spectral domain optical coherence tomography having an A-scan spacing of 5.9 [mu]m and a B-scan spacing of 11 [mu]m. En face slabs were derived from this data set at distances 50 [mu]m to 90 [mu]m above the Bruch membrane reference plane to image the subretinal drusenoid deposit and also 6 [mu]m below Bruch membrane to image the level of the choriocapillaris. The corresponding infrared ...

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    19. Difference in correspondence between visual field defect and inner macular layer thickness measured using three types of spectral-domain OCT instruments

      Difference in correspondence between visual field defect and inner macular layer thickness measured using three types of spectral-domain OCT instruments

      Purpose To compare the relationship between visual field sensitivity (VFS) and macular parameters measured using three spectral-domain optical coherence tomography (SD-OCT) instruments and to determine a base level (=floor effect) for macular parameters. Methods We imaged 127 glaucomatous eyes (1 eye per subject) using three different OCT instruments, i.e., the Cirrus , RTVue and 3D OCT devices; 76 normal eyes were evaluated as controls using the same instruments. The thicknesses of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer+inner plexiform layer (GCL/IPL), and mRNFL+GCL/IPL (GCC) were analyzed. The VFS of the area analyzed by ...

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    20. Drusen and RPE atrophy automated quantification by optical coherence tomography in an elderly population

      Drusen and RPE atrophy automated quantification by optical coherence tomography in an elderly population

      Purpose Correlate OCT-derived measures of drusen and retinal pigment epithelium (RPE) atrophy areas (RAs) with demographic features in an elderly population. Patients and methods Subjects aged 50 years and older underwent Cirrus OCT scanning. Drusen area and volume were obtained from the macula within a central circle (CC) of 3   mm and a surrounding perifoveal ring (PR) of 3–5   mm, using the RPE analysis software (6.0). RA measurements were generated for the 6 × 6   mm 2 retinal area. Gender, age, smoking status, and systolic blood pressure (SBP) were considered. Results A total of 434 eyes were included. RA ...

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    21. Spectral domain optical coherence tomography characteristics in diabetic retinopathy

      Spectral domain optical coherence tomography characteristics in diabetic retinopathy

      Purpose: To report the appearance of diabetic retinopathy lesions using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: A total of 287 eyes of 199 subjects were included. All the subjects underwent complete ophthalmic examination including SD-OCT. Results: The appearance of various lesions of diabetic retinopathy and the retinal layers involved were reported. In subjects with macular edema the prevalence of incomplete PVD was 55.6%. Conclusion: SD-OCT brings new insights into the morphological changes of the retina in diabetic retinopathy.

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    22. Evaluation of Retinal Nerve Fiber Layer Thickness in Acromegalic Patients Using Spectral-Domain Optical Coherence Tomography

      Evaluation of Retinal Nerve Fiber Layer Thickness in Acromegalic Patients Using Spectral-Domain Optical Coherence Tomography

      Purpose : To evaluate retinal nerve fiber layer (RNFL) thickness in acromegalic patients . Methods : A study group of 29 patients with acromegaly and a control group of 38 age-matched healthy individuals were enrolled in a cross-sectional study. The study group was further divided by tumor size into two subgroups, a macroadenoma group and a microadenoma group. Serum growth hormone (GH) and insulin-like growth factor-1 (IGF-I) levels were detected at the time of ophthalmological examination in the study group. In both the study and control group, the RNFL thickness in the four quadrants was measured by optical coherence tomography . The relationship between ...

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