1. Articles in category: Ophthalmology

    577-600 of 5615 « 1 2 ... 22 23 24 25 26 27 28 ... 232 233 234 »
    1. Feature Of The Week 9/15/13: Longitudinal Fundus and Retinal Studies with SD-OCT: A Comparison of Five Mouse Inbred Strains

      Feature Of The Week 9/15/13: Longitudinal Fundus and Retinal Studies with SD-OCT: A Comparison of Five Mouse Inbred Strains

      The mouse is a well established model for studying hereditary disorders, which have an effect on eye structure and function, including frequently occurring degenerative retinal diseases, such as retinitis pigmentosa. However, many of these retinal disorders remain to be characterized functionally to understand the underlying mechanisms and develop strategies for therapeutic intervention. Recently, a commercial third-generation SD-OCT system (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) was adapted for high-resolution in vivo imaging of the mouse fundus and retinal morphology. This system has successfully been implemented into the first-line phenotyping of the German Mouse Clinic I (GMC I; www.mouseclinic.de) as ...

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    2. Changes in Optical Coherence Tomography Findings in Acute Zonal Occult Outer Retinopathy

      Changes in Optical Coherence Tomography Findings in Acute Zonal Occult Outer Retinopathy

      Purpose: To report a case of acute zonal occult outer retinopathy (AZOOR) in a 39-year-old woman. Methods: Images were obtained with fundus photography and optical coherence tomography (OCT). A multifocal electroretinogram (mfERG) was also obtained to evaluate retinal function. Results: The patient's right visual acuity was 0.8. Fundus photographs showed no specific abnormal findings. OCT showed attenuation of the photoreceptor inner segment/outer segment (IS/OS) line and the cone outer segment tip (COST) line in the right eye. The mfERG showed corresponding amplitude reductions. One month after the initial visit, her right visual acuity improved to 1 ...

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    3. Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography

      Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography

      Aqueous leaves the anterior chamber of eye by passing through the trabecular meshwork (TM), a tissue thought to be responsible for increased outflow resistance in glaucoma. Motion assessment could permit characterization of TM biomechanical properties necessary to maintain intra-ocular pressure (IOP) within a narrow homeostatic range. In this paper, we report the first in vivo identification of TM motion in humans. We use a phase-sensitive optical coherence tomography (PhS-OCT) system with sub-nanometer sensitivity to detect and image dynamic pulse-induced TM motion. To permit quantification of TM motion and relationships we develop and apply a phase compensation algorithm permitting removal of ...

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    4. Assessing the effects of ketorolac and acetazolamide on macular thickness by optical coherence tomography following cataract surgery

      Assessing the effects of ketorolac and acetazolamide on macular thickness by optical coherence tomography following cataract surgery

      We aimed to evaluate the efficacy of topical ketorolac 0.5 % solution and oral acetazolamide 250 mg/day delivery during the first month after uneventful phacoemulsification surgery by measuring the macular thickness using optical coherence tomography. Our nonmasked randomized prospective study comprised 87 eyes of 80 patients. Complete follow-up was achieved on 84 eyes of 77 eligible patients. Postoperatively, the patients were divided into three groups. One group received ketorolac 0.5 %, the other group received acetazolamide 250 mg/day, and the control group was given no agent. Macular thickness and volume were measured at 1 week and 1 month ...

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    5. New method for evaluation of early phase tear clearance by anterior segment optical coherence tomography

      New method for evaluation of early phase tear clearance by anterior segment optical coherence tomography

      Purpose To describe a new method of measuring early phase tear clearance by anterior segment optical coherence tomography (AS-OCT). Methods Sixty normal subjects were divided into a young group (30 subjects; 29.6 ± 7.2 years) and an elder group (30 subjects; 71.4 ± 10.8 years). AS-OCT (CASIA SS-1000, Tomey, Japan) with customized software was used to record the tear meniscus at the centre of the lower eyelid. Five microlitres of lukewarm saline solution was dropped into the lower conjunctival sac, and an image of the tear meniscus was obtained immediately and again 30 seconds after natural blinking. The ...

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    6. Branch retinal vein occlusion and vitreovascular traction: a preliminary spectral domain OCT case-control study

      Branch retinal vein occlusion and vitreovascular traction: a preliminary spectral domain OCT case-control study

      Objective Branch retinal vein occlusion (BRVO) typically occurs at an arteriovenous (AV) crossing site. Although the pathogenesis is unclear, vitreovascular traction might have a significant role in some BRVO cases. The purpose of present study was to determine the incidence of vitreoretinal traction at the obstruction site in patients diagnosed with BRVO. Methods In this prospective observational case–control study, 32 consecutive BRVO patients were studied with spectral-domain optical coherence tomography (SD-OCT) to detect the presence of vitreovascular traction or vitreous adherence at the occlusion site. Results SD-OCT directed to the occlusion site revealed a vitreovascular traction at this point ...

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    7. Swept-source anterior segment optical coherence tomography in late-onset capsular block syndrome: High-resolution imaging and morphometric modifications after posterior capsulotomy

      Swept-source anterior segment optical coherence tomography in late-onset capsular block syndrome: High-resolution imaging and morphometric modifications after posterior capsulotomy

      Purpose To study the characteristics of late-onset capsular block syndrome (CBS) using swept-source anterior segment optical coherence tomography (AS-OCT) and assess morphometric variations after treatment with neodymium:YAG (Nd:YAG) laser posterior capsulotomy. Setting Ophthalmology, University of Parma, Parma, Italy. Design Case series. Methods Patients with late-onset CBS had an ophthalmology evaluation, including slitlamp photography and AS-OCT, before and 1 month after ND:YAG laser posterior capsulotomy. The diameter of the anterior capsulorhexis, the posterior displacement of the posterior capsule, and the anterior chamber depth (ACD) were measured using AS-OCT. Measurements before and after Nd:YAG laser posterior capsulotomy were ...

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    8. In vivo Optical Coherence Tomography of Light-Driven Melanosome Translocation in Retinal Pigment Epithelium

      In vivo Optical Coherence Tomography of Light-Driven Melanosome Translocation in Retinal Pigment Epithelium

      Optical coherence tomography (OCT) may revolutionize fundamental investigation and clinical management of age-related macular degeneration and other eye diseases. However, quantitative OCT interpretation is hampered due to uncertain sub-cellular correlates of reflectivity in the retinal pigment epithelium (RPE) and photoreceptor. The purpose of this study was twofold: 1) to test OCT correlates in the RPE, and 2) to demonstrate the feasibility of longitudinal OCT monitoring of sub-cellular RPE dynamics. A high resolution OCT was constructed to achieve dynamic imaging of frog eyes, in which light-driven translocation of RPE melanosomes occurred within the RPE cell body and apical processes. Comparative histological ...

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    9. Inner Macular Hyperreflectivity Demonstrated by Optical Coherence Tomography in Niemann-Pick Disease

      Inner Macular Hyperreflectivity Demonstrated by Optical Coherence Tomography in Niemann-Pick Disease

      We describe spectral-domain optical coherence tomography (OCT; Heidelberg Spectralis) imaging of 3 patients with Niemann-Pick disease type B. This expands the range of previously reported anatomical correlates of the ophthalmoscopic macular halo surrounding the “cherry-red spot.”

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    10. SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years

      SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years

      Purpose: To describe the natural course of type 2 idiopathic macular telangiectasia (MT) using spectral-domain optical coherence tomography (SD-OCT). Methods: Analysis of the different stages of progression of type 2 MT during a period of 3 years using multimodal imaging, including SD-OCT correlated with angiographic and autofluorescence images. The analysis of the different steps was obtained initially from the first eye, then successively from the fellow eye when progressive changes appeared. Results: The earliest visible alteration at SD-OCT was the interruption of the interface between inner segment and ellipsoid (IS/EL) (stage 1). The second stage was characterized by the ...

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    11. Cleveland Clinic Receives NIH Grant for Interoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives NIH Grant for Interoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Received a 2013 NIH Grant for $203,124 for Interoperative Optical Coherence Tomography for Ophthalmic Surgery. The principal investigator is Justis Ehlers. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Project Summary Optical coherence tomography (OCT) has revolutionized the management of ophthalmic diseases with the precise anatomic information it provides with non-invasive imaging. The high-resolution cross-sectional tissue details make OCT a natural complement to ophthalmic surgery. Intraoperative OCT (iOCT) has the potential to provide real-time feedback to surgeons thus improving surgical care and outcomes. This research activity will focus ...

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    12. Macular spectral domain optical coherence tomography findings in Tanzanian endemic optic neuropathy

      Macular spectral domain optical coherence tomography findings in Tanzanian endemic optic neuropathy

      Bilateral optic neuropathy in Dar es Salaam is now considered endemic and is estimated to affect 0.3–2.4% of young adults. The condition is characterized by a subacute bilateral loss of central vision of unknown aetiology. Findings of spectral domain optical coherence tomography have not previously been reported for these patients. All patients diagnosed with endemic optic neuropathy over a 2-year period at the Muhimbili National Hospital underwent spectral domain optical coherence tomography macular imaging. Scans were graded qualitatively for severity of retinal nerve fibre layer loss as well as the presence of microcystic macular changes, which have ...

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    13. Choroidal Thickness Measurement in Children Using Optical Coherence Tomography

      Choroidal Thickness Measurement in Children Using Optical Coherence Tomography

      Purpose: To measure choroidal thickness (CT) in children of various ages by using spectral optical coherence tomography with enhanced depth imaging and to investigate the association between subfoveal CT and ocular axial length, age, gender, weight, and height in children. Methods: Healthy children were prospectively included between May and August 2012. Optical coherence tomography with the enhanced depth imaging system (Spectralis, Heidelberg, Germany) was used for choroidal imaging at nine defined points of the macula of both eyes. Axial length was measured using IOLMaster (Carl Zeiss Meditec, Dublin, CA). Height, weight, and refraction were recorded. Interobserver agreement in readings was ...

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    14. Efficacy of intacs intrastromal corneal ring segment relative to depth of insertion evaluated with anterior segment optical coherence tomography

      Efficacy of intacs intrastromal corneal ring segment relative to depth of insertion evaluated with anterior segment optical coherence tomography

      AIM: To evaluate the effect of implantation depth of Intacs microthin prescription inserts (Addition Technology Inc, Fremont, California) on visual and topographic outcomes in patients with post- laser-assisted in situ keratomileusis (LASIK) ectasias. SETTINGS AND DESIGN: Retrospective, observational case series. MATERIALS AND METHODS: In this case series, 16 eyes of 12 patients were evaluated. All cases were post-LASIK ectasia that had undergone intrastromal corneal ring segment (ICRS) implantation. The planned insertion depth was 70% of stromal thickness using a manual dissector. At least 12 months postoperatively, all eyes underwent Visante (Carl Zeiss Meditec) AS-OCT to determine insertion depth. Cases were ...

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    15. Sclerochoroidal Calcification Is Primarily a Scleral Condition Based on Enhanced Depth Imaging Optical Coherence Tomography

      Sclerochoroidal Calcification Is Primarily a Scleral Condition Based on Enhanced Depth Imaging Optical Coherence Tomography

      Sclerochoroidal calcification (SC) is found in elderly white individuals with calcium pyrophosphate deposition in the sclera and/or choroid, appearing as a typical yellow subretinal mass usually along the retinal vascular arcades. 1 - 4 Most cases are idiopathic, but some have a systemic relationship. 1 - 2 We review multimodal imaging findings of SC.

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    16. Longitudinal spectral domain optical coherence tomography changes in eyes with intraocular lymphoma

      Longitudinal spectral domain optical coherence tomography changes in eyes with intraocular lymphoma

      Background Cases of patients with primary intraocular lymphoma (PIOL) were retrospectively analyzed to describe the longitudinal intra-retinal morphological changes in PIOL as visualized on images obtained by spectral domain optical coherence tomography (SD-OCT). Results In a retrospective case series, Heidelberg Spectralis SD-OCT images obtained in the longitudinal evaluation of patients with biopsy-proven PIOL were analyzed and assessed. The images were graded for the presence of macular edema (ME), pigment epithelial detachment (PED), subretinal fluid (SRF), and hyperreflective signals. SD-OCT scans of five eyes from five patients were assessed. Patients showed signs of inflammation, such as ME and SRF, which were ...

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    17. Assessment of Choroidal Thickness and Volume during the Water Drinking Test by Swept-Source Optical Coherence Tomography

      Assessment of Choroidal Thickness and Volume during the Water Drinking Test by Swept-Source Optical Coherence Tomography

      Objective To evaluate changes in peripapillary and macular choroidal thickness and volume after the water-drinking test (WDT) using swept-source optical coherence tomography (SS OCT). Design Prospective, cross-sectional, observational study. Participants Fifty-six eyes of 28 healthy volunteers. Methods Participants underwent a 3-dimensional optic disc and macula scanning protocol with a prototype SS OCT (Topcon, Inc., Tokyo, Japan) at baseline and 15, 30, 45, and 120 minutes after the start of the WDT. The WDT consisted of drinking 1000 ml of water within 5 minutes. Objective measurements of the choroid were obtained with automated segmentation of the choroidal boundaries. Main Outcome Measures ...

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    18. The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography

      The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography

      Background/Aims: Retinal nerve fiber layer (RNFL) thinning has been observed on histopathology and time-domain optical coherence tomography in many diseases of the central nervous system. In this study, with a higher resolution of spectral-domain optical coherence tomography (SDOCT), we detected RNFL changes in patients with multiple sclerosis (MS) in China, and compared RNFL thickness between eyes with and without optic neuritis (ON). Methods: In this retrospective, nonrandom case study, the patients were recruited from the Affiliated Sir Run Run Shaw Hospital of Zhejiang University. RNFL thickness was measured for each eye using SDOCT. The controls were recruited from the ...

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    19. Normative spectral domain optical coherence tomography data on macular and retinal nerve fiber layer thickness in Indians

      Normative spectral domain optical coherence tomography data on macular and retinal nerve fiber layer thickness in Indians

      Aim : To provide the normative data of macular and retinal nerve fiber layer (RNFL) thickness in Indians using spectral domain OCT (Spectralis OCT, Heidelberg Engineering, Germany) and to evaluate the effects of age, gender, and refraction on these parameters. Design : Observational, cross-sectional study. Materials and Methods : The eyes of 105 healthy patients aged between 20-75 years, with no ocular disease and best corrected visual acuity of 20/20, were scanned using standard scanning protocols by a single examiner. Exclusion criteria included glaucoma, retinal diseases, diabetes, history of prior intraocular surgery or laser treatment. The mean macular and RNFL thickness were ...

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    20. Effect of Contact Lens on Optical Coherence Tomography Imaging of Rodent Retina

      Effect of Contact Lens on Optical Coherence Tomography Imaging of Rodent Retina

      Visibility of optical coherence tomography (OCT) images can be severely degraded by speckle noise. A computationally efficient despeckling approach that strongly reduces the speckle noise is reported. It is based on discrete wavelet transform (DWT), but eliminates the conventional process of threshold estimation. By decomposing an image into different levels, a set of sub-band images are generated, where speckle noise is additive. These sub-band images can be compounded to suppress the additive speckle noise, as DWT coefficients resulting from speckle noise tend to be approximately decorrelated. The final despeckled image is reconstructed by taking the inverse wavelet transform of the ...

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    21. A Fast Algorithm for Automatic Detection of Anterior Chamber Angle Points and Measurement of Central Corneal Thickness for Anterior Chamber OCT Images

      A Fast Algorithm for Automatic Detection of Anterior Chamber Angle Points and Measurement of Central Corneal Thickness for Anterior Chamber OCT Images

      This paper proposed a fast algorithm to detect anterior chamber angle points and measure central corneal thickness for anterior chamber optical coherence tomography (OCT) images automatically. This algorithm uses biggest connected regions method to get the anterior chamber region, and detects the anterior chamber angle points (ACAPs) in this region firstly. Secondly, the algorithm uses ACAPs to obtain the real position of central cornea then measures the central corneal thickness of anterior chamber. The proposed algorithm was tested on 74 anterior chamber OCT images and provided accurate measurements in about 90 milliseconds.

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    22. Comparison of Heidelberg retina tomography, optical coherence tomography and Humphrey visual field in early glaucoma diagnosis

      Comparison of Heidelberg retina tomography, optical coherence tomography and Humphrey visual field in early glaucoma diagnosis

      Objective To determine the value of optic disc parameters and perimetric defects in the early diagnosis of patients with primary open-angle glaucoma (POAG). Methods Optic disc parameters and perimetry were compared among patients in the early stage of POAG, patients with suspected POAG and healthy control subjects, using Heidelberg retina tomography (HRT-II), optical coherence tomography (OCT) and a Humphrey 750 i automatic field analyser, in order to determine whether these parameters could be used for early POAG diagnosis. Results A total of 55 participants were enrolled in the study. Significant differences in the optic disc parameter and perimetry values were ...

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    23. Comparison of ability of time-domain and spectral-domain optical coherence tomography to detect diffuse retinal nerve fiber layer atrophy

      Comparison of ability of time-domain and spectral-domain optical coherence tomography to detect diffuse retinal nerve fiber layer atrophy

      Purpose Our aim was to evaluate and compare diagnostic capabilities of time-domain (Stratus) and spectral-domain (Cirrus) optical coherence tomography (OCT) to detect diffuse retinal nerve fiber layer (RNFL) atrophy. Methods This study assessed 101 eyes from 101 glaucoma patients with diffuse RNFL atrophy and 101 eyes from 101 age-matched healthy individuals. Two experienced glaucoma specialists graded red-free RNFL photographs of eyes with diffuse RNFL atrophy using a four-level grading system. The area under the receiver operating characteristic curves (AUC) of normal eyes was compared with that of eyes with diffuse atrophy. Sensitivity and specificity of each OCT device were calculated ...

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