1. Articles in category: Ophthalmology

    577-600 of 6670 « 1 2 ... 22 23 24 25 26 27 28 ... 276 277 278 »
    1. Automated 3-D Retinal Layer Segmentation of Macular Optical Coherence Tomography Images with Serous Pigment Epithelial Detachments

      Automated 3-D Retinal Layer Segmentation of Macular Optical Coherence Tomography Images with Serous Pigment Epithelial Detachments

      Automated retinal layer segmentation of optical coherence tomography (OCT) images has been successful for normal eyes but becomes challenging for eyes with retinal diseases if the retinal morphology experiences critical changes. We pro-pose a method to automatically segment the retinal layers in 3 - D OCT data with serous retinal pigment epithelial detachments (PED), which is a prominent feature of many chorioretinal disease processes. The proposed framework consists of the following steps: fast denoising and B-scan alignment, multi-resolution graph search based surface detection, PED region detection and surface correction above the PED region. The proposed technique was evaluated on a dataset ...

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    2. Novel optical coherence tomography classification of torpedo maculopathy

      Novel optical coherence tomography classification of torpedo maculopathy

      Background Torpedo maculopathy is a rare condition with a twofold clinical significance. Firstly, it is a differential of atypical congenital hypertrophy of the retinal pigment epithelium. Secondly, visual field loss has been reported. We demonstrate the spectrum of structural abnormality of torpedo maculopathy as seen on optical coherence tomography, and correlate this with age of presentation, fundus autofluorescence, retinal sensitivity loss and visual field abnormality. Design A retrospective, observational case series. Participants Five Australian patients seen between 2008 and 2013. Methods Fundus photography, optical coherence tomography, fundus autofluorescence and visual field analysis. One patient underwent fluorescein angiography. Main Outcome Measures ...

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    3. Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes

      Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes

      Background/aims Choroidal thickness measurements are reported to differ between swept source optical coherence tomography (SS-OCT) and spectral domain OCT (SD-OCT). This study aimed to assess the comparability of choroidal thickness measurements using SS-OCT and SD-OCT devices among patients with retinal diseases and normal participants. Methods In a prospective cohort study of 100 subjects, comprising patients with retinal disease and normal volunteers, OCT scans were performed sequentially with the DRI OCT-1 and Spectralis OCT using standardised imaging protocols. Subfoveal choroidal thicknesses were independently measured by masked reading-centre certified graders. Paired t tests and intraclass correlation coefficients (ICCs) were used to ...

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    4. System For Calculating Center Of Anterior Capsule And Method Therefor

      System For Calculating Center Of Anterior Capsule And Method Therefor

      A method for calculating the center of the anterior capsule includes the steps of: photographing the eyeball of a patient with an optical coherence tomography; generating a 3-dimensional image and coordinates based on the data obtained by the optical coherence tomography; photographing the eyeball of the patient to produce an eyeball image; and matching the 3-dimensional image and coordinates to the eyeball image so as to calculate the center of the anterior capsule of the patient. A system for calculating the center of the anterior capsule includes: an optical coherence tomography apparatus for photographing the eyeball of a patient with ...

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    5. Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography) (Textbook)

      Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography)  (Textbook)

      The book discusses the clinical possibilities of Angio-OCT. Most imaging in the book (77 figures in Chapters 5, 7.1 and 10) has been performed with XR-Avanti Optovue SD-OCT device using SSADA algorithm. A few figures in chapters 3, 7.2 and 8 have been performed with a swept source OCT prototype using SSADA algorithm. Another technique is described in chapter 11, using ultrahigh speed, SS-OCT and its applications to optical coherence tomography-angiography (OCTA). Key Features Angio-OCT (Dyeless OCT Angiography) is a new TECHNOLOGY that gives already useful results, that can be applied to day-to-day clinical ophthalmology. Several different OCT ...

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    6. Hemifield pattern electroretinogram in ocular hypertension: comparison with frequency doubling technology and optical coherence tomography to detect early optic neuropathy

      Hemifield pattern electroretinogram in ocular hypertension: comparison with frequency doubling technology and optical coherence tomography to detect early optic neuropathy

      Background: To assess the sensitivity and specificity of hemifield pattern electroretinogram (HF-PERG) for detecting early retinal ganglion cell (RGC) damage in ocular hypertensive (OH) patients. Methods: Fifty-two OH patients (mean age 56±9.6 years) with an intraocular pressure (IOP) >21 mmHg were assessed. All subjects underwent HF-PERG, optical coherence tomography (OCT), and frequency doubling technology (FDT) visual field. Results: OH patients showed a significant increase of peak-time of the N95 ( P =0.027) compared to controls. The amplitude of the N95 of the lower and upper HF-PERG showed significant differences ( P =0.037 and P =0.023, respectively) between ...

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    7. In Situ Circular Compression and Doppler Optical Coherence Tomography Studies on Effects of Diabetic Mellitus on Vesa Nervonum of Sciatic Nerve

      In Situ Circular Compression and Doppler Optical Coherence Tomography Studies on Effects of Diabetic Mellitus on Vesa Nervonum of Sciatic Nerve

      Diabetes mellitus is one of the most common diseases in the world and can causemany types of neuropathies, and even mortality. It is therefore important to understand how diabetes mellitus alters the mechanical properties of nerve tissues and their blood vessels. In this study, in situ compression-and-hold circular compression tests were applied to the sciatic nerves of both diabetic rats and normal rats. Doppler optical coherence tomography ( Doppler OCT ) was then utilized to monitor the configuration of the arterioles in two groups of rats. The force data acquired in the compression tests were fitted by using Fung’s quasi-linear viscoelastic ...

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    8. Predictive Findings of Visual Outcome in Spectral Domain Optical Coherence Tomography after Ranibizumab Treatment in Age-related Macular Degeneration

      Predictive Findings of Visual Outcome in Spectral Domain Optical Coherence Tomography after Ranibizumab Treatment in Age-related Macular Degeneration

      Purpose To investigate which spectral domain optical coherence tomography (SD-OCT) findings predict visual outcome after anti-vascular endothelial growth factor (VEGF) treatment in neovascular age-related macular degeneration (NV-AMD). Methods We reviewed the medical records of patients with treatment-naïve NV-AMD who underwent three or more consecutive anti-VEGF injections. The patients were divided into three groups according to their changes of visual acuity (VA); improved (group I), static (group S), or worsened (group W). We assessed the incidences and values of all available SD-OCT findings of these groups, compared these findings between the three groups and compared the initial values with the ...

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    9. Analysis of Fundus Shape in Highly Myopic Eyes by Using Curvature Maps Constructed from Optical Coherence Tomography

      Analysis of Fundus Shape in Highly Myopic Eyes by Using Curvature Maps Constructed from Optical Coherence Tomography

      Purpose To evaluate fundus shape in highly myopic eyes using color maps created through optical coherence tomography (OCT) image analysis. Methods We retrospectively evaluated 182 highly myopic eyes from 113 patients. After obtaining 12 lines of 9-mm radial OCT scans with the fovea at the center, the Bruch’s membrane line was plotted and its curvature was measured at 1-µm intervals in each image, which was reflected as a color topography map. For the quantitative analysis of the eye shape, mean absolute curvature and variance of curvature were calculated. Results The color maps allowed staphyloma visualization as a ring ...

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    10. Electrooculography and Optical Coherence Tomography Reveal Late-Onset Best Disease

      Electrooculography and Optical Coherence Tomography Reveal Late-Onset Best Disease

      Purpose: Best vitelliform macular dystrophy, also known as Best disease, is a macular dystrophy characterized by bilateral yellowish egg yolk-like lesion(s) present within the maculae. It is a slowly progressive disease that usually presents at childhood. Best vitelliform macular dystrophy frequently proceeds through stages, beginning with a classic presentation described as vitelliform. A similar condition, known as adult-onset foveomacular vitelliform dystrophy, has been described among adult patients. Although the two maculopathies may look similar, they are considered two separate entities, because of the age of onset and overall clinical presentation. Case Report: A 54-year-old man presented with gradual-onset blurred ...

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    11. Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study

      Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study

      Purpose The purpose of this study was to assess choroidal thickness in migraine patients during acute migraine attacks and compare them with healthy controls, using spectral domain optical coherence tomography (OCT). Patients and methods In this prospective case–control study, choroidal thicknesses of 46 migraine patients during acute migraine attacks and 46 age- and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain-OCT device. All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (0900 hours), in order to minimize the effects of diurnal variation. Results There was ...

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    12. Choroid in Myopic Choroidal Neovascularization Measured Using SD-OCT

      Choroid in Myopic Choroidal Neovascularization Measured Using SD-OCT

      Purpose Using the spectral domain optical coherence tomography (SD-OCT), we studied the difference in the choroidal morphology between the choroidal neovascularization (CNV) area and the area surrounding CNV. Methods This retrospective study consisted of 19 patients with myopic CNV lesion in eye; fellow eyes were used as controls. All eyes were analyzed by measuring the choroidal thickness and large choroidal vessel size using SD-OCT. Eyes with CNV were divided into groups; the neovascular lesion was defined as group 1, the surrounding area as group 2. Subfovea of the fellow eye was defined as group 3. Results The choroidal thickness was ...

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    13. Difference in Subfoveal Choroidal Thickness between Two Spectral-Domain Optical Coherence Tomography Systems

      Difference in Subfoveal Choroidal Thickness between Two Spectral-Domain Optical Coherence Tomography Systems

      Purpose To determine the difference in subfoveal choroidal thickness between two spectral-domain optical coherence tomography (SD-OCT) systems in normal eyes and eyes with retinal diseases. Methods Thirty-three normal eyes and 49 eyes with retinal disease (13 eyes with diabetic retinopathy, 28 eyes with epiretinal membrane and eight eyes with macular hole) were enrolled in the study. Subfoveal choroidal thicknesses were measured by 3 observers using the enhanced depth imaging technique of Heidelberg Spectralis® and the high-definition five-line raster scan of Cirrus HD-OCT® using calipers within the program. Differences between the measured values were analyzed with a paired t -test in ...

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    14. Influence of Image Compression on the Interpretation of Optical Coherence Tomography in Diabetic Macular Edema

      Influence of Image Compression on the Interpretation of Optical Coherence Tomography in Diabetic Macular Edema

      Purpose To evaluate the influence of image compression on optical coherence tomography (OCT) images in eyes with diabetic macular edema (DME). Methods Twenty eyes of 30 patients diagnosed with DME were included in this retrospective observational case series. Horizontal OCT scans centered at the center of the fovea were conducted using spectral-domain OCT (Spectral OCT/SLO®). The images were exported to Tag Image File Format (TIFF) and then transformed to 10, 5, and 1 quality of Joint Photographic Experts Group (JPEG) format using Photoshop. OCT images were taken before and after intravitreal bevacizumab injection. The presence of intraretinal fluid, foveolar ...

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    15. Macular Volume Loss In Huntington’s Disease On Optical Coherence Tomography- A Pilot Biomarker Study

      Macular Volume Loss In Huntington’s Disease On Optical Coherence Tomography- A Pilot Biomarker Study

      Background Optical coherence tomography (OCT) is a novel, non-ionising, retinal nerve fibre layer (RNFL) imaging modality with rapid, consistent data acquisition and a much shorter scan time versus MRI. In Alzheimer’s disease, Parkinson’s disease and multiple sclerosis, RNFL loss is proposed as a surrogate marker of brain neuronal loss. In related polyglutamine disorders, Spinocerebellar Ataxia 7 (SCA 7), retinal degeneration is well established clinically. In a recent OCT study of 9 Spinocerebellar Ataxia 1 (SCA1) patients, significant RNFL loss versus controls was seen. In Huntington’s disease, drosophila models show photoreceptor degeneration, while both R6/1 and R6 ...

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    16. Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Purpose : To evaluate the performance of a full-field optical coherence tomography (FF-OCT) system in the study of human donor and pathological corneas and assess its suitability for use in eye banks. Methods : Our study was carried out using an FF-OCT system developed for non-invasive imaging of tissue structures in depth with ultrahigh resolution (1 µm in all directions). Images were acquired from eight stored human donor corneas (either edematous or after deswelling) and five surgical specimens of corneas with various diseases (bullous keratopathy, lattice corneal dystrophy, stromal scar after keratitis, keratoconus and Fuchs dystrophy). They were compared with standard histology ...

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    17. Outcomes of laser peripheral iridotomy in angle closure subgroups according to anterior segment optical coherence tomography parameters

      Outcomes of laser peripheral iridotomy in angle closure subgroups according to anterior segment optical coherence tomography parameters

      Purpose: To investigate the effect of laser peripheral iridotomy (LPI) in subgroups of angle closure eyes based on anterior segment optical coherence tomography (AS OCT)-derived parameters. Methods: Angle closure (primary angle closure (PAC) or PAC glaucoma (PACG)) eyes were imaged using ASOCT before and 2 weeks after LPI. A hierarchical cluster analysis was performed using AS OCT parameters obtained before LPI, such as anterior chamber depth (ACD), anterior chamber width (ACW), iris cross-sectional area (IA), Angle opening distance and iris thickness at 750 µm from the scleral spur (AOD750 , IT750), iris curvature (IC), lens vault (LV), and anterior chamber ...

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    18. Use of Anterior Segment Optical Coherence Tomography to Predict Corneal Graft Rejection in Small Animal Models

      Use of Anterior Segment Optical Coherence Tomography to Predict Corneal Graft Rejection in Small Animal Models

      Purpose: To correlate the degree of anterior chamber (AC) inflammation and corneal thickness evaluated by anterior segment optical coherence tomography (ASOCT) with corneal graft rejection status and to explore the value of ASOCT in assisting the diagnosis or prediction of graft rejection using a rat penetrating keratoplasty (PK) model. Methods: A total of 40 PKs were performed using Fisher rats (allogeneic groups) and Lewis rats (syngeneic group) as donors and Lewis rats as recipients: isograft control group (n=10), allograft untreated group (n=10), and allograft with 1% prednisolone acetate treatment group (n=20). All the grafts were evaluated for ...

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    19. Associations of macular thickness in spectral-domain OCT with ocular and systemic cardiovascular parameters - The MIPH Eye & Health Study

      Associations of macular thickness in spectral-domain OCT with ocular and systemic cardiovascular parameters - The MIPH Eye & Health Study

      Purpose Beyond in-vivo histological analysis of retinal tissue, optical coherence tomography (OCT) allows quantitative image analysis. This study evaluates associations of macular retinal thickness measured with spectral-domain OCT (SD-OCT) and ocular and systemic cardiovascular parameters in adult subjects. Methods An epidemiological cross-sectional study was performed in the staff of a European high-tech company. Examination of known cardiovascular risk factors including biochemical blood analysis was performed, and ocular parameters such as refraction, tonometry, SD-OCT imaging of the macula and cornea, and fundus photography were evaluated. Retinal thickness measurements were evaluated according to the ETDRS grid. Associations of macular retinal thickness and ...

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    20. "EN FACE" OPTICAL COHERENCE TOMOGRAPHY IMAGING IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

      "EN FACE" OPTICAL COHERENCE TOMOGRAPHY IMAGING IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

      Purpose: To comprehensively evaluate the retinal and choroidal changes in eyes with Type 2 idiopathic macular telangiectasia using “en face” and B-scan spectral domain optical coherence tomography (OCT), and to compare their respective contributions to this evaluation. Methods: Eyes with a diagnosis of proliferative or nonproliferative Type 2 macular telangiectasia were prospectively studied. All patients underwent an extensive ophthalmologic examination including biomicroscopic fundus examination, color photography, fundus autofluorescence, fluorescein angiography, B-scan and en face spectral domain OCT. Results: Twenty eyes of 10 patients were included in this study. En face OCT C-scans and conventional B-scans were both able to show ...

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    21. OCT Angiography in Wet AMD

      OCT Angiography in Wet AMD

      The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) evaluate patients undergoing treatment for wet AMD determine if reduced flow to the choroid is a risk factor for developing wet AMD.

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    22. A physical model eye with 3D resolution test targets for optical coherence tomography

      A physical model eye with 3D resolution test targets for optical coherence tomography

      Optical coherence tomography (OCT) has been widely employed as non-invasive 3D imaging diagnostic instrument, particularly in the field of ophthalmology. Although OCT has been approved for use in clinic in USA, Europe and Asia, international standardization of this technology is still in progress. Validation of OCT imaging capabilities is considered extremely important to ensure its effective use in clinical diagnoses. Phantom with appropriate test targets can assist evaluate and calibrate imaging performance of OCT at both installation and throughout lifetime of the instrument. In this paper, we design and fabricate a physical model eye with 3D resolution test targets to ...

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