1. Articles in category: Ophthalmology

    577-600 of 6234 « 1 2 ... 22 23 24 25 26 27 28 ... 258 259 260 »
    1. Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Background To investigate the image quality of wide-angle cross-sectional and reconstructed fundus images based on ultra-megahertz swept-source Fourier domain mode locking (FDML) OCT compared to current generation diagnostic devices. Methods A 1,050 nm swept-source FDML OCT system was constructed running at 1.68 MHz A-scan rate covering approximately 70° field of view. Twelve normal eyes were imaged with the device applying an isotropically dense sampling protocol (1,900 × 1,900 A-scans) with a fill factor of 100 %. Obtained OCT scan image quality was compared with two commercial OCT systems (Heidelberg Spectralis and Stratus OCT) of the same 12 eyes ...

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    2. Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Purpose: To describe the imaging characteristics and to investigate the prognostic factors of acute retinal pigment epitheliitis. Methods: In this retrospective observational case series, a total of 18 patients (18 eyes) with acute retinal pigment epitheliitis were included. The features of acute retinal pigment epitheliitis were analyzed by spectral-domain optical coherence tomography (SD-OCT). Results: SD-OCT images obtained at baseline revealed abnormal reflectivity in the retinal pigment epithelium (RPE) inner layer in every case (18 eyes, 100%). The line corresponding to the RPE inner layer, the inner segment ellipsoid (ISe), showed abnormal reflectivity in 16 cases (89%). Among patients with ISe ...

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    3. Influence of image compression on the interpretation of spectral-domain optical coherence tomography in exudative age-related macular degeneration

      Influence of image compression on the interpretation of spectral-domain optical coherence tomography in exudative age-related macular degeneration

      Purpose To evaluate the effect of image compression of spectral-domain optical coherence tomography (OCT) images in the examination of eyes with exudative age-related macular degeneration (AMD). Methods Thirty eyes from 30 patients who were diagnosed with exudative AMD were included in this retrospective observational case series. The horizontal OCT scans centered at the center of the fovea were conducted using spectral-domain OCT. The images were exported to Tag Image File Format (TIFF) and 100, 75, 50, 25 and 10 % quality of Joint Photographic Experts Group (JPEG) format. OCT images were taken before and after intravitreal ranibizumab injections, and after relapse ...

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    4. Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter

      Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter

      IM: To compare the RTVue spectral optical coherence tomography (SD-OCT), Sirius Scheimpflug-Placido topographer, Lenstar optical low coherence reflectometry (OLCR) and ultrasound pachymetry (USP) devices in terms of their agreement and repeatability of measuring central corneal thickness (CCT). METHODS: In this prospective study, 50 eyes of 50 patients were included. Three repeated measures were obtained using SD-OCT, Scheimpflug-Placido topographer and USP and five measurements were determined with the OLCR. Bland-Altman plots were used to assess agreement among the instruments, and 95% limits of agreement (LoA) for each comparison were calculated. Intra-examiner repeatability was assessed using intraclass correlation coefficients (ICCs). RESULTS: The ...

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    5. A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      To estimate the potential outcomes of spectral domain optical coherence tomography (SD-OCT) screening among African American patients in the US, a decision analysis model was used to synthesize the current evidence and to project visual function outcomes over a 10 year time horizon. The secondary intent of this study was to assess the cost of the screening implementation. Methods: Using a Monte Carlo micro-simulation model with a 10 year time horizon, we evaluated the impact of SD-OCT screening among African American patients on visual field loss and evaluated the associated costs of screening and treatment. Results: Based upon the model ...

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    6. Scanning laser ophthalmoscopy and optical coherence tomography imaging of spectacular ecdysis in the corn snake (Pantherophis guttatus) and the California king snake (Lampropeltis getulus californiae) - Cazalot - 2014 - Veterinary Ophthalmology

      Scanning laser ophthalmoscopy and optical coherence tomography imaging of spectacular ecdysis in the corn snake (Pantherophis guttatus) and the California king snake (Lampropeltis getulus californiae) - Cazalot - 2014 - Veterinary Ophthalmology

      Purpose One of the singularities of the eyes of snakes is the presence of the spectacle, a transparent and vascularized integument covering the cornea. The spectacle is completely renewed during ecdysis. Combined scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and conventional macrophotography were used to image this phenomenon. Material and Methods A spectral OCT/SLO examination and macrophotography were performed in four healthy adult corn snakes ( Pantherophis guttatus ) and one healthy adult California king snake ( Lampropeltis getulus californiae ) the day before the start of ecdysis and then daily during ecdysis. Results In all animals, ecdysis lasted 5 days. The ...

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    7. Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography (SD-OCT) is a widely used method to observe retinal layers and follow pathological events in human. Recently, this technique has been adapted for animal imaging. This non-invasive technology brings a cross-sectional visualization of the retina, which permits to observe precisely each layer. There is a clear expansion of the use of this imaging modality in rodents, thus, a precise characterization of the different outer retinal layers observed by SD-OCT is now necessary to make the most of this technology. The identification of the inner strata until the outer nuclear layer has already been clearly established, while ...

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      Mentions: Michel Pâques
    8. Voxeleron introduces Orion, advanced optical coherence tomography (OCT) analysis software.

      Voxeleron introduces Orion, advanced optical coherence tomography (OCT) analysis software.

      Voxeleron introduces Orion, advanced optical coherence tomography (OCT) analysis software. Orion is fully-automated soft-ware, rapidly and accurately segmenting seven retinal layers in OCT images. The limited functionality of existing OCT analysis tools has meant that only two or three retinal layers are analyzed, despite the overwhelming evidence for the clinical importance of the inner retinal layers in disease detection and prognosis. Orion address-es exactly this technology gap, providing researchers much needed biomarkers for the early detection and prognosis of ophthalmic and neurological diseases. Orion is device independent, processing data from different OCT vendors. Orion will be featured in two posters ...

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      Mentions: Voxeleron
    9. Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

      Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

      Background: The aim of this study was to evaluate the reproducibility of the posterior pole asymmetry analysis (PPAA) in glaucomatous eyes and healthy controls in comparison to retinal nerve fiber layer measurements (RNFL) with spectral domain optical coherence tomography (SD-OCT). Patients and Methods: Prospectively, in a single session by one operator, three measurements were taken of the retinal thickness with the PPAA and three measurements of the RNFL with the eye-tracker function of the Heidelberg Spectralis SD-OCT. Results: The mean intraclass correlation coefficient (ICC) and lower confidence intervals (in parentheses) for PPAA were 0.98 (0.96) in both healthy ...

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    10. Heidelberg completes CET programme

      Heidelberg completes CET programme

      Heidelberg Engineering has completed a three-month national peer discussion programme that provided OCT training for 300 practitioners. Peer discussion sessions entitled OCT in Acute Vision Loss took place in the Wirral, Oxford, Manchester, Sheffield, Hemel Hempstead, Leeds, Epsom and Wolverhampton. A variety of case studies and peer discussions were presented by Christopher Mody (pictured), Heidelberg Engineering’s clinical programme manager.

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    11. Anterior segment optical coherence tomography documentation of a case of topiramate induced acute angle closure

      We present a case report of a 31-year-old female patient who presented to us with a 1 day history of acute bilateral eye pain, blurred vision and headache. She was found to have a myopic shift, raised intraocular pressure (IOP) and shallow anterior chambers in both eyes. She had been commenced on oral topiramate 1 week previously. A number of investigations, including anterior segment optical coherence tomography (AS-OCT) were done and a diagnosis of topiramate induced bilateral acute angle closure (TiAAC) was made. Topiramate was discontinued and she was managed with topical and oral antiglaucoma medications, topical steroids and cyclopegics ...

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    12. Morphological changes in spectral domain optical coherence tomography guided bevacizumab injections in wet age-related macular degeneration, 12-months results

      Morphological changes in spectral domain optical coherence tomography guided bevacizumab injections in wet age-related macular degeneration, 12-months results

      Purpose: To describe retinal changes during Spectral Domain Optical Coherence Tomography (SD-OCT) guided bevacizumab treatment for neovascular age- related macular degeneration (AMD). Settings and Design: Single center observational study. Materials and Methods: We confirmed wet AMD in 47 eyes of 45 patients by fluorescein angiography and SD-OCT. After bevacizumab injection, we examined the patients at 4-week intervals. During each follow-up control, we performed SD-OCT and a complete ophthalmic examination. Criteria for reinjection were visual acuity loss of more than five ETDRS letters, and/or increase of central retinal thickness, sub-retinal fluid, intra-retinal fluid, pigment epithelium detachment. If reinjection criteria were ...

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    13. Influence of disc area on retinal nerve fiber layer thickness measurement by spectral domain optical coherence tomography

      Influence of disc area on retinal nerve fiber layer thickness measurement by spectral domain optical coherence tomography

      Background: To examine the effect of optic disc area on peripapillary RNFLT (retinal nerve fiber layer thickness) measurement at circle diameter of 3.4 mm around optic nerve head using spectral OCT/SLO (Optical coherence tomography/scanning laser ophthalmoscope). Materials and Methods : In this prospective, cross sectional study, one hundred and two eyes of 102 normal subjects underwent RNFLT and disc area measurement using spectral OCT/SLO. Based on disc area, subjects were divided into three groups i.e., <3 mm 2 (32 eyes), 3-4 mm 2 (36 eyes) and >4 mm 2 (34 eyes). The effect of disc area ...

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    14. Flexible, Multimodal Retina Image Recording System And Measurement System

      Flexible, Multimodal Retina Image Recording System And Measurement System

      The proposed solution serves for diagnosing retinal disorders, in which conventional fundus recordings are complemented by 2D slice data records or 3D data records obtained by means of optical coherence tomography (OCT). To this end, the device according to the invention consists of a fundus camera with an OCT measurement module, in which, after the focusing objective, a mirror switches the light to be detected either to the OCT measurement module or an image detector. This design also renders it possible to carry out a method for improved focusing in order to improve the recording quality of the individual modalities ...

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    15. Qualitative and quantitative analysis of filtering blebs with optical coherence tomography

      Qualitative and quantitative analysis of filtering blebs with optical coherence tomography

      Objective To provide a qualitative and quantitative analysis of filtering blebs with optical coherence tomography (OCT) in patients after primary trabeculectomy. Design Evaluation of diagnostic technology. Participants We retrospectively studied 20 eyes of 20 patients who had a fornix-based flap in primary trabeculectomy: 14 with mitomycin C (MMC) and 6 without MMC. Methods Filtering blebs were examined using 2 types of OCTs working at a wavelength of 840 and 1310 nm. In this study, we analyzed both the OCT morphologic pattern and the internal structures of blebs, including bleb wall thickness, scleral flap thickness, and the route under the scleral ...

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    16. Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography

      Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography

      Purpose To noninvasively evaluate the effects of corneal hydration and collagen crosslinking (CXL) on the mechanical behavior of the cornea. Setting Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA. Design Experimental study. Methods An optical coherence elastography (OCE) technique was used to measure the displacement behavior of 5 pairs of debrided human donor globes in 3 serial states as follows: edematous, normal thickness, and after riboflavin–ultraviolet-A–mediated CXL. During micromotor-controlled axial displacements with a curved goniolens at physiologic intraocular pressure (IOP), serial optical coherence tomography scans were obtained to allow high-resolution intrastromal speckle tracking and displacement measurements over the ...

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    17. Hyperreflective Foveal Lesion Observed With Optical Coherence Tomography in Cases of Epiretinal Membranes With A Firm Foveal Attachment

      Hyperreflective Foveal Lesion Observed With Optical Coherence Tomography in Cases of Epiretinal Membranes With A Firm Foveal Attachment

      Purpose: To report the optical coherence tomography (OCT) findings of the firmly attached foveal area and to investigate the functional results and predictive values in correlation to the degree of firmness of the foveal adherence of the epiretinal membrane (ERM). Methods: We retrospectively reviewed the medical records regarding 167 eyes of 166 patients who underwent vitrectomy for the removal of the ERM between January 2009 and December 2012. We evaluated the degree of foveal attachment in all the patients based on the surgical video and reviewed the OCT images. The main and secondary outcome measures were OCT findings including the ...

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    18. Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study

      Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study

      Significant integrative advances are needed for intraoperative optical coherence tomography ( i OCT) to achieve widespread use across ophthalmic surgery. A surgeon feedback system that provides microscope integration, heads-up display and foot pedal control of the OCT scan location represents a major interval advance in ophthalmic surgery. In this report, we describe the preliminary findings of the Determination of feasibility of Intraoperative Spectral domain microscope Combined/integrated OCT Visualisation during En face Retinal and ophthalmic surgery (DISCOVER) study, a multisurgeon investigational device study examining the role of microscope integrated i OCT systems with surgeon heads-up display feedback (eg, Carl Zeiss Meditec ...

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    19. Retinal nerve fibre layer and macular thickness analysis with Fourier domain optical coherence tomography in subjects with a positive family history for primary open angle glaucoma

      Retinal nerve fibre layer and macular thickness analysis with Fourier domain optical coherence tomography in subjects with a positive family history for primary open angle glaucoma

      Aim To detect early structural changes of retinal nerve fibre layer (RNFL) and macular ganglion cell complex (GCC) in subjects with a positive family history for primary open angle glaucoma (POAG) using Fourier domain optical coherence tomography (FD-OCT) (RTVue-100). Methods This was a cross-sectional observational study. First and second degree relatives of POAG patients, healthy subjects, and subjects with preperimetric glaucoma (PPG) without a family history for glaucoma, were enrolled. All participants underwent complete ophthalmic examination, visual field test and FD-OCT (RTVue-100) imaging. Average RNFL and GCC thicknesses were measured and a pattern analysis was applied to the GCC map ...

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    20. Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has revolutionises the diagnosis of retinal disease based on the detection of microscopic rather than subcellular changes in retinal anatomy. However, currently the technique is limited to the detection of microscopic rather than subcellular changes in retinal anatomy. However, coherence based imaging is extremely sensitive to both changes in optical contrast and cellular events at the micrometer scale, and can generate subtle changes in the spectral content of the OCT image. Here we test the hypothesis that OCT image speckle (image texture) contains information regarding otherwise unresolvable features such as organelle changes arising in the early ...

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    21. “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

      “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

      Purpose . The recent use of “en-face” enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS). Methods . Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan (“en-face”) EDI SD-OCT at the initial visit and during follow-up. Results . C-scans combined with the other multimodal imaging enabled the visualization of retinal damage. Acute lesions appeared as diffuse and focal disruptions occurring in the ellipsoid and interdigitation zones. The match between autofluorescence imaging, indocyanine green angiography, and “en-face” OCT helped identify the acute microstructural damages in ...

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    22. Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      PURPOSE: To measure macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and to correlate these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve. METHODS: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), the combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were qualitatively assessed for microcysts in the ...

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    23. A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      Purpose: The purpose of this work was to gather preliminary data on tear film stability and the adhesive properties of the corneal surface in dry eye patients and control-group subjects, using a new, minimally invasive OCT imaging method. Methods: Eighty-five human subjects were screened for dry eye and classified in two groups, as dry eye or normal patients. Sodium carboxymethylcellulose (NaCMC) adhesiveness over the central cornea was measured using Fourier Domain anterior segment optical coherence tomography (OCT). The corneal adhesiveness for NaCMC was compared between the two groups, correlated with classical tests, and analyzed for diagnostic validity and repeatability. Results ...

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