1. Articles in category: Ophthalmology

    577-600 of 8580 « 1 2 ... 22 23 24 25 26 27 28 ... 356 357 358 »
    1. Adaptive Optics for Ophthalmic Technologies

      Adaptive Optics for Ophthalmic Technologies

      This is a feasibility study to assess the use of wide field adaptive optics optical coherence tomography (WF-AO-OCT) to determine whether there are structural differences in the peripheral retina in participants diagnosed with diabetic retinopathy compared to a healthy control group. This study being conducted under an abbreviated IDE. The investigators will analyze data using descriptive statistics. Risks related to light exposure will be managed by ensuring that the exposure to the WF-AO-OCT light source is well below maximum permissible limits for safe exposure.

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    2. Effect of Spectral Domain Optical Coherence Tomography Image Quality on Macular Thickness Measurements and Error Rate

      Effect of Spectral Domain Optical Coherence Tomography Image Quality on Macular Thickness Measurements and Error Rate

      Purpose : To evaluate the effect of Topcon spectral domain optical coherence tomography (OCT) image quality on macular thickness measurements and the error rate in healthy subjects and patients with clinically significant diabetic macular edema (CSME). Methods : In this prospective, comparative case series, macular thickness measurements, and the rate of decentration and segmentation errors were evaluated before and after reducing the image quality factor (QF). The measurements were evaluated again after correcting the decentration and segmentation errors. To reduce the image QF below 45, tetracycline eye ointment was applied on the corneal surface. Results : Forty eyes of 40 subjects including 18 ...

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    3. Using continuous intraoperative optical coherence tomography to classify swirling lens fragments during cataract surgery and to predict their impact on corneal endothelial cell damage

      Using continuous intraoperative optical coherence tomography to classify swirling lens fragments during cataract surgery and to predict their impact on corneal endothelial cell damage

      Purpose To quantify and classify swirling lens fragments during cataract surgery and record their impact on the corneal endothelium using continuous intraoperative optical coherence tomography (OCT). Setting Vienna Institute for Ocular Surgery, Hanusch Hospital, Vienna, Austria. Design Prospective case series. Methods Patients scheduled for cataract surgery without other ophthalmologic comorbidities were included. During surgery, continuous OCT recordings were performed to measure and score swirling lens fragments that came into contact with the corneal endothelium. Endothelial cell density (ECD) was measured preoperatively and 1 month postoperatively. In addition, the central corneal thickness and aqueous flare were measured preoperatively and 1 hour ...

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    4. Cataractous mountain on the corneal horizon: Swept-source optical coherence tomography

      Cataractous mountain on the corneal horizon: Swept-source optical coherence tomography

      Anterior segment optical coherence tomography (AS-OCT) resolves ocular structures to a degree comparable to that of ultrasound (US) biomicroscopy; in some cases, such as visualization of the scleral spur, AS-OCT provides superior images.1 Swept-source AS-OCT is based on time-encoded Fourier-domain OCT technology and uses a rapidly tunable laser light source.

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    5. Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis

      Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis

      Introduction: Optic disc hypoplasia is a common feature in fetal alcohol syndrome. Thus, we aimed to evaluate the optic disc morphology changes and the peripapillary retinal nerve fiber layer thickness in these patients. Material and Methods: We performed spectral-domain optical coherence tomography in a cohort of 11 patients (22 eyes) with fetal alcohol syndrome and in an age-matched control group. We evaluated optic nerve head parameters (optic disc area and diameter, rim area, cup/disc horizontal and vertical ratios) and peripapillary retinal nerve fiber layer thickness. Results: Mean optic disc area, rim area and optic disc diameter were, respectively, in ...

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    6. Relationship between Functional and Structural Changes in Diabetic Vessels in Optical Coherence Tomography Angiography

      Relationship between Functional and Structural Changes in Diabetic Vessels in Optical Coherence Tomography Angiography

      The decorrelation signals in optical coherence tomography angiography (OCTA) are derived from the flow of erythrocytes and concomitantly delineate the retinal vasculature. We compared the structural and functional characteristics of vascular lesions visualized in fluorescein angiography (FA), OCTA, and en-face OCT images in 53 eyes (28 patients) with diabetic retinopathy (DR). The foveal avascular zone (FAZ) areas in OCTA images in the superficial layer almost corresponded to those in FA images. The FAZ areas in the en-face OCT images in the superficial layer were smaller than those in the FA images and correlated with each other, which agreed with the ...

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    7. Study of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema

      Study of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema

      Background 26 million people were estimated to be affected by diabetes in 2010 across the globe. Diabetic macular edema (DME) is the most important cause of visual impairment due to diabetic retinopathy. Optical Coherence Tomography (OCT) is a non-invasive modality which produces cross-sectional or three-dimensional, high-resolution images of the retinal layers and quantitative assessment of retinal thickness Aim of study was to study the incidence of different patterns of diabetic macular edema on Optical coherence tomography (OCT), to decide treatment & follow-up protocol. Material & Methods 200 eyes of 167 patients attending the M & J Institute of Ophthalmology and having diabetic macular ...

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    8. Pitfalls in Optical Coherence Tomography Imaging: Essentials for correct interpretation

      Pitfalls in Optical Coherence Tomography Imaging: Essentials for correct interpretation

      Optical coherence tomography (OCT) is widely used in the diagnosis and detection of glaucomatous progression. Many manufacturers make spectral-domain OCT (SD-OCT) devices, the most widely used type of OCT. In contrast to time-domain OCT, with SD-OCT, a greater area of the retina can be measured without interpolation of data. Additionally, the anterior segment can be imaged using the same machine. Most OCT machines have built-in proprietary software that can measure the peripapillary area as well as the macular region. Most units also have the capability of segmentation analysis, providing data regarding substructures of the retina. These data are presented in ...

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      Mentions: Sanjay G. Asrani
    9. Characteristics of Peripapillary Staphylomas Associated with High Myopia Determined by Swept-source Optical Coherence Tomography

      Characteristics of Peripapillary Staphylomas Associated with High Myopia Determined by Swept-source Optical Coherence Tomography

      Purpose To analyze the morphological features of peripapillary staphylomas associated with high myopia by swept-source optical coherence tomography (OCT). Design Validity analysis. Methods Highly myopic patients (refractive error >8.0 diopters or axial length >26.5 mm) with a peripapillary staphyloma who had undergone swept-source OCT were studied. The non-highly myopic fellow eyes in patients with unilateral high myopia were also studied. The presence of a peripapillary staphyloma was determined by stereoscopic ophthalmoscopic examinations. The OCT features of the peripapillary staphylomas and other peripapillary lesions were evaluated. Results Twenty-five eyes of 16 patients were studied. Twenty-two eyes were highly myopic ...

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    10. LONGITUDINAL FOLLOW-UP OF CHOROIDAL GRANULOMAS USING ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      LONGITUDINAL FOLLOW-UP OF CHOROIDAL GRANULOMAS USING ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To assess the ability of enhanced depth imaging optical coherence tomography (EDI-OCT) in detecting variations in the structure and size of choroidal granulomas in response to treatment and to compare these findings with indocyanine green angiography (ICGA). Methods: EDI-OCT and ICGA images of choroidal granulomas in eyes of patients diagnosed with tubercular or sarcoid uveitis were obtained at baseline and follow-up visits. Two independent masked observers analyzed the lesions to compare changes in their structural features such as shape, reflectivity, and margins, among others, through time. The size of each lesion was manually measured on EDI-OCT and ICGA images ...

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    11. Longitudinal time‑domain optic coherence study of retinal nerve fiber layer in IFNβ‑treated and untreated multiple sclerosis patients

      Longitudinal time‑domain optic coherence study of retinal nerve fiber layer in IFNβ‑treated and untreated multiple sclerosis patients

      Quantification of the retinal nerve fiber layer (RNFL) by optical coherence tomography (OCT) has been proposed to provide an indirect measure for retinal axonal loss. The aim of the present study was to determine whether interferon beta (IFNβ) treatment impedes retinal axonal loss in multiple sclerosis (MS) patients. A total of 48 patients with MS (24 IFNβ‑1b‑treated and 24 untreated subjects) and 12 healthy controls were enrolled in a prospective longitudinal OCT study. OCT measurements were performed for both eyes of each subject at baseline, and at 3‑, 6‑, and 12‑month follow‑up examinations using a time ...

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    12. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES

      Purpose: To demonstrate the clinical utility of optical coherence tomography (OCT) angiography (OCT-A) in inherited retinal dystrophies complicated by choroidal neovascularization (CNV). Methods: Optical coherence tomography angiography and structural OCT were performed using a 70-kHz spectral domain OCT system using the split-spectrum amplitude-decorrelation angiography algorithm. Semiautomated image processing software was used to segment and measure the CNV. Results: Four participants were enrolled to study the following inherited retinal dystrophies complicated by CNV: choroideremia, EFEMP1-related retinopathy, Best vitelliform dystrophy, and adult-onset vitelliform dystrophy. Interpretation of fluorescein angiography was difficult because of abnormal retinal architecture but suggested the presence of CNV. Structural ...

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    13. Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles

      Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles

      Objective To assess the agreement between intraoperative measurements of the limbus-insertion distance of the extraocular muscles with those measured by spectral domain optical coherence tomography. Methods An analysis was made of a total of 67 muscles of 21 patients with strabismus. The limbus-insertion distance of the horizontal rectus muscles were measured using pre-operative SD-OCT and intra-operatively in 2 ways: 1) direct, after a conjunctival dissection in patients who underwent surgery, or 2) transconjunctival in patients who were treated with botulinum toxin, or in those who were not going to be operated. The intraclass correlation coefficient and Bland-Altman plots were calculated ...

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    14. Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters

      Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters

      Background . Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods . A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was performed. In parallel, a broad range of systemic cardiovascular parameters were measured. Associations were analyzed using a generalized estimating equations’ model ...

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    15. Clinical applications of spectral domain optical coherence tomography in retinal diseases

      Clinical applications of spectral domain optical coherence tomography in retinal diseases

      Optical coherence tomography (OCT) was introduced about two decades ago and has revolutionized ophthalmic practice in recent years. It is a noninvasive noncontact imaging modality that provides a high-resolution cross-sectional image of the cornea, retina, choroid and optic nerve head, analogous to that of the histological section. Advances in OCT technology in signal detection technique from time-domain (TD) to spectral-domain (SD) detection have given us the potential to study various retinal layers more precisely and in less time. SD-OCT better delineates structural changes and fine lesions in the individual retinal layers. Thus, we have gained substantial information about the pathologic ...

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    16. Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography

      Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography

      Aims To describe the vascular abnormalities in patients affected by retinitis pigmentosa (RP) by means of optical coherence tomography angiography (OCT-A). Methods Cross-sectional case series; patients with RP presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited. Inclusion criteria were: diagnosis of RP, clear ocular media, adequate pupillary dilation, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, short-wavelength fundus autofluorescence (SW-FAF), and 3×3 Swept Source OCT-A. 30 healthy subjects were chosen as controls. The main outcome was identification of abnormalities in density of the superficial capillary plexus ...

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    17. Optical coherence tomography of outer retinal holes in senile retinoschisis and schisis-detachment

      Optical coherence tomography of outer retinal holes in senile retinoschisis and schisis-detachment

      Purpose On clinical examination, it can be challenging to differentiate retinoschisis with outer retinal hole from schisis-detachment. This study examined the role of outer retinal hole spectral domain optical coherence tomography (SD-OCT) imaging in conjunction with imaging of the posterior schisis cavity edge in differentiating between these conditions. Methods This is a retrospective case series. Out of 500 subjects with ICD-9 diagnoses of senile retinoschisis (361.10, 361.11, 361.12, 361.19) from January 2004 to December 2014, 62 had evidence of retinoschisis on fundus photography or optical coherence tomography (OCT). Six eyes of five patients had outer retinal ...

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    18. Determination and Validation of Thresholds of Anterior Chamber Parameters by Dedicated Anterior Segment Optical Coherence Tomography

      Determination and Validation of Thresholds of Anterior Chamber Parameters by Dedicated Anterior Segment Optical Coherence Tomography

      Purpose To determine and validate thresholds of anterior chamber angle (ACA) parameters in discriminating open versus narrow angle eyes using images from dedicated anterior segment optical coherence tomography (DASOCT). Design Reliability analysis Methods Eyes imaged by DASOCT and examined with gonioscopy were reviewed. By gonioscopy, eyes were classified as narrow if posterior trabecular meshwork was not visible and open if the angle was open to scleral spur and beyond. Imaging was performed in the dark with the CASIA SS-1000 (Tomey, Nagoya, Japan). ACA parameters angle opening distance (AOD), trabecular-iris space area (TISA), trabecular-iris circumference volume (TICV), length of irido-trabecular contact ...

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    19. Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Purpose The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts which might help to distinguish SHRM subtypes. Design Validity analysis. Methods Patients with age-related macular degeneration (AMD), myopia, pachychoroid disease and macular dystrophy, manifesting SHRM on optical coherence tomography (OCT), were recruited. Clinical chart review and multimodal imaging established ...

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    20. Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis with Active Lesions

      Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis with Active Lesions

      Purpose To describe optical coherence tomography angiography (OCTA) findings in multifocal choroiditis (MFC) with active lesions and to characterize the concordance between the OCTA and other traditional imaging modalities. Design Reliability and validity analysis. Methods Patients with suspected choroidal neovascularization (CNV) or acute inflammatory lesions associated with MFC were assessed in this study. All participants underwent preliminary traditional multimodal imaging including color fundus photography, fundus autofluorescence, near-infrared reflectance imaging, spectral-domain optical coherence tomography, and fluorescence angiography (FA). The participants were prospectively recruited to perform OCTA. OCTA findings of active lesions were compared with other traditional imaging results. Vascular flow signal ...

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    21. Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans

      Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans

      Purpose To describe optical coherence tomography angiography (OCTA) findings in multifocal choroiditis (MFC) with active lesions and to characterize the concordance between the OCTA and other traditional imaging modalities. Design Reliability and validity analysis. Methods Patients with suspected choroidal neovascularization (CNV) or acute inflammatory lesions associated with MFC were assessed in this study. All participants underwent preliminary traditional multimodal imaging including color fundus photography, fundus autofluorescence, near-infrared reflectance imaging, spectral-domain optical coherence tomography, and fluorescence angiography (FA). The participants were prospectively recruited to perform OCTA. OCTA findings of active lesions were compared with other traditional imaging results. Vascular flow signal ...

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    22. Optovue announces new AngioVue Retina imaging option commercial availability

      Optovue announces new AngioVue Retina imaging option commercial availability

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce the immediate availability of Optovue AngioVue Retina, a proprietary imaging option that provides retina specialists with a non-invasive, dyeless way to quickly visualise blood flow in the retina. AngioVue Retina is configured with essential OCT-A and OCT features, designed specifically for retinal practices to allow adoption of OCT and OCT-A into the clinical workflow with minimal disruption. John Hawley, Senior Vice President of global sales for Optovue, said, “By adding AngioVue Retina to our product portfolio, we are able to help retinal ...

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      Mentions: Optovue Haag-Streit
    23. The EASE Study - Human Factor and Usability Testing of a Binocular OCT System

      The EASE Study - Human Factor and Usability Testing of a Binocular OCT System

      Ophthalmology is among the most technology driven of all medical specialties, with advanced medical imaging devices - and specialised computer software - increasingly adopted for routine clinical use. While many such devices are capable of completing specific tasks, lack of "usability" prevents their widespread adoption (i.e., such devices are not easy to learn and remember, or are not efficient or subjectively pleasing to use). Moreover, devices that are difficult to use expose patients to clinical risk as a result of human error during usage. With the introduction of a new medical technology, it is essential, therefore, to have a deep understanding ...

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    24. Multimodal Imaging: Redefining Retinal Disease With Current Technology

      Multimodal Imaging: Redefining Retinal Disease With Current Technology

      Ophthalmic imaging has long been a mainstay of the diagnosis and treatment of eye disease. This aspect of retinal specialists’ practice has undergone many recent advances, leading to an expanding structural understanding of disease processes. The combination of multiple imaging modalities has helped retinal physicians to further understand disease progression and treatment response. In the era of multimodal imaging, recent observations have helped to clarify the underlying pathogenesis of many retinal diseases. Each imaging “modality” has tissue-specific characteristics that have allowed for the redefinition of many common retinal conditions and have led to an evolution of our understanding of vitreoretinal ...

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