1. Articles in category: Ophthalmology

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    1. SHORT-TERM EFFECTS OF EXERCISE ON OPTIC NERVE AND MACULAR PERFUSION MEASURED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      SHORT-TERM EFFECTS OF EXERCISE ON OPTIC NERVE AND MACULAR PERFUSION MEASURED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To evaluate the effects of exercise on optic nerve and macular perfusion using optical coherence tomography angiography. Methods: Thirteen eyes of 13 healthy volunteers were examined using a high-speed and high-resolution spectral-domain optical coherence tomography XR Avanti with a split-spectrum amplitude-decorrelation angiography algorithm. Blood pressure, heart rate, the mean area of the foveal avascular zone , and flow density on the optic nerve head and macula, before and after exercise were measured and analyzed. Results: Mean patient age was 27.3 +/- 3.5 years. Heart rate, systolic and diastolic blood pressure increased significantly after exercise (P < 0.001). The mean ...

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    2. EN-FACE OPTICAL COHERENCE TOMOGRAPHY IMAGING IN A CASE OF CHOROIDAL RUPTURE

      EN-FACE OPTICAL COHERENCE TOMOGRAPHY IMAGING IN A CASE OF CHOROIDAL RUPTURE

      Purpose: To report a case of choroidal rupture resulting due to blunt trauma using en-face optical coherence tomography (OCT) imaging. Methods: Case report. Results: A 22-year-old man sustained a blunt trauma to his right eye. At the initial examination, four lesions with a subretinal hemorrhage were observed during a fundus examination of the macular area including the fovea, but the findings under the lesions were unclear. The authors observed the extent of the minute findings noninvasively by en-face OCT imaging from the initial examination. Six months after the trauma, the fine crescent-shaped lines seen by angiography and OCT B-scan images ...

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    3. Optical coherence tomography angiography (OCTA) and retinal microvascular ramification in AMN and PAMM

      Optical coherence tomography angiography (OCTA) and retinal microvascular ramification in AMN and PAMM

      The recent review by Bhavsar and colleagues 2 on Acute macular neuroretinopathy (AMN) makes important points drawing on the availability of new multimodal imaging modalities. We agree with the concept that capillary plexus ischemia causes AMN and Paracentral acute middle maculopathy (PAMM). In this context the authors make a convincing point for the future role optical coherence tomography (OCT) angiography (OCTA) likely will play in the diagnostic work up.

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      Mentions: Axel Petzold
    4. Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme

      Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme

      Abstract Purpose To describe the presence of continuous ectopic inner foveal layers associated with epiretinal membranes (ERMs) and to present a new optical coherence tomography (OCT) staging system of ERMs. Design Retrospective multicenter observational case series. Methods Clinical charts and Spectral-Domain OCT images of 194 eyes of 172 consecutive patients diagnosed with ERMs were reviewed and analyzed. Results The presence of continuous ectopic inner foveal layers was identified in 63 out of 194 eyes (32.5%) and this morphology was significantly associated with lower visual acuity. ERMs were divided in four stages. Stage 1 (43 out of 194 eyes, 22 ...

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    5. Ultra-wide Field Imaging and Swept Source Optical Coherence Tomography of Ocular Electrical Injury in a Child

      Ultra-wide Field Imaging and Swept Source Optical Coherence Tomography of Ocular Electrical Injury in a Child

      History of trauma in children may be obscured and physicians often rely on signs for diagnosis. The authors discuss a case of electrical injury where ocular signs led to diagnosis of the cause of macular atrophy. A high index of suspicion must always be maintained in such atypical cases, and the setting of electrical injury to the body requires meticulous ocular examination.

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    6. Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography

      Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography

      Purpose: To compare the lamina cribrosa (LC) intensity in glaucoma-suspect eyes and eyes with mild to moderate glaucoma using swept-source optical coherence tomography. Methods: Optic disc volume scans were collected using swept-source optical coherence tomography in 19 clinically defined glaucoma-suspect eyes and 29 eyes with mild to moderate glaucoma. LC intensity was measured using Image J software, and the resultant values were normalized using the retinal pigment epithelium and vitreous signal. Results: Mean age was 53.7+/-18.5 years in the glaucoma-suspect eyes and 63.0+/-16.1 years in the eyes with mild to moderate glaucoma (P=0 ...

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    7. USC Roski Eye Institute Joins the ARVO Campaign to Promote the Impact of Optical Coherence Tomography, USC Clinician/Scientist one of OCT Inventors

      USC Roski Eye Institute Joins the ARVO Campaign to Promote the Impact of Optical Coherence Tomography, USC Clinician/Scientist one of OCT Inventors

      Celebrating 25 years of the revolutionary impact of optical coherence tomography (OCT) on eye care around the world, the University of Southern California (USC) Roski Eye Institute , which helped pioneer OCT, has partnered with the Association for Research in Vision and Ophthalmology ( ARVO ) on an OCT education and advocacy campaign. The ARVO campaign includes a series of public-friendly videos , educational tools and advocacy resources on the discovery and development of OCT, an imaging technology used to visualize the back of the eye (i.e., the retina) without the need for dilation. The short videos feature testimony from patients, clinicians and ...

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    8. Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye

      Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye

      While fs-lasers are clinically established for surgery in the anterior eye, their use in the posterior eye is impeded by aberrations and focus position errors. We implemented a laboratory system to investigate whether fs-laser surgery in the posterior eye is made more feasible by aberration correction and tomographic image guidance. Aberration correction is obtained by adaptive optics (AO) and the image guidance is accomplished by optical coherence tomography (OCT). System characteristic measurements and cutting experiments were performed inside an eye model. By aberration correction, wavefront errors were reduced from 270 nm root-mean-square (rms) to 64 nm rms, ignoring Zernike terms ...

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    9. Latest Developments in OCT Enhance Its Role in Glaucoma Care

      Latest Developments in OCT Enhance Its Role in Glaucoma Care

      N ow that spectral-domain OCT (SD-OCT) has made its way into nearly every glaucoma practice, doctors and patients are benefitting from its advanced capabilities. Its faster image acquisition speed improves resolution, reproducibility and repeatability, enabling new strategies for achieving the ultimate goal in glaucoma care: objective detection of disease progression. “Determining whether a patient is getting worse or not getting worse is our holy grail,” says Robert J. Noecker, MD, a glaucoma specialist with Ophthalmic Consultants of Connecticut. “Today’s OCT instruments give us more confidence in what we’re seeing from scan to scan.” The basis for how Dr ...

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    10. Macular Vascular Flow Area and Vascular Density in Healthy Population Using Optical Coherence Tomography Angiography

      Macular Vascular Flow Area and Vascular Density in Healthy Population Using Optical Coherence Tomography Angiography

      We read with interest the paper from Coscas et al. 1 regarding the normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography (OCT-A). The authors state that using the AngioVue OCT-A system (Optovue, Inc., Fremont, CA, USA), the total vascular density in superficial capillary plexus in healthy adults is 52.58 ± 3.22% and for the deep vascular density is 57.87 ± 2.82%. Optical coherence tomography angiography technology has some major limitations in clinical practice nowadays: variable segmentation, motion artifact, and project artifact. 2 We must take into ...

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      Mentions: Optovue Nidek
    11. Morphological differences between optic disc collaterals and neovascularization on optical coherence tomography angiography

      Morphological differences between optic disc collaterals and neovascularization on optical coherence tomography angiography

      Background To study morphological features of optic disc venous collaterals (OVCs) and neovascularization of optic disc (NVD) on optical coherence tomography angiography (OCTA). Methods Patients with OVCs and NVDs secondary to ischemic retinal diseases were prospectively enrolled. Multimodal imaging was performed using color fundus photography, fluorescein angiography (FA), and OCTA. Morphological evaluation of en-face structural OCT, cross-sectional and en-face OCTA was performed. Results Twenty eyes (20 patients; OVCs: n  = 10 and NVD: n  = 10) were included. OVCs appeared as small, loopy vessels distinct from surrounding peripapillary capillaries on OCTA in the radial peripapillary capillary frame. NVDs appeared as a mesh ...

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      Mentions: Vishali Gupta
    12. Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging

      Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging

      Purpose To present en face optical coherence tomography (OCT) images generated by graph-search theory algorithm-based custom software and examine correlation with other imaging modalities. Methods En face OCT images derived from high density OCT volumetric scans of 3 healthy subjects and 4 patients using a custom algorithm (graph-search theory) and commercial software (Heidelberg Eye Explorer software (Heidelberg Engineering)) were compared and correlated with near infrared reflectance, fundus autofluorescence, adaptive optics flood-illumination ophthalmoscopy (AO-FIO) and microperimetry. Results Commercial software was unable to generate accurate en face OCT images in eyes with retinal pigment epithelium (RPE) pathology due to segmentation error at ...

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    13. Retinal nerve fiber layer thickness in a healthy Turkish population measured by optical coherence tomograph

      Retinal nerve fiber layer thickness in a healthy Turkish population measured by optical coherence tomograph

      BACKGROUND: Normative optical coherence tomography (OCT) data is required for different subsets of the population as ethnic differences in retinal nerve fiber layer (RNFL) thickness have been reported. An OCT database for the normal Turkish population is not commercially available. OBJECTIVES: Quantify peripapillary RNFL thickness in a Turkish population. DESIGN: Cross-sectional, descriptive study. SETTING: Numune Training and Research Hospital, Adana, Turkey. SUBJECTS AND METHODS: RNFL measurements performed by Spectral OCT with a circular scan with 3.4 mm circle were centered around the optic disc of the right eye of each subject. Correlation of the effects of age and gender ...

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    14. Dispersion measurements in ocular media using a dual-wavelength swept source optical coherence tomography system

      Dispersion measurements in ocular media using a dual-wavelength swept source optical coherence tomography system

      Optical coherence tomography (OCT) has proved to be a powerful tool for the detection of microstructure in tissue. Label-free tissue differentiation on a micron scale is a promising and powerful technique for segmentation. This Letter describes a technique using a dual-wavelength OCT system to image the eye. We measure the walk-off between interfaces in A-scans, taken at two different wavelengths, to calculate the average group velocity dispersion parameter of each segment of the eye. We present measurements of the dispersion of the cornea and the aqueous humour in rat eyes.

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    15. Characterizing the Occluded Lacrimal Punctum Using Anterior Segment Optical Coherence Tomography

      Characterizing the Occluded Lacrimal Punctum Using Anterior Segment Optical Coherence Tomography

      Purpose: Epiphora is sometimes associated with an absent or occluded lacrimal drainage punctum (or puncta). This study uses noninvasive "enhanced depth" anterior segment optical coherence tomography (OCT) to give improved characterization and understanding of absent or fully occluded puncta and the underlying canaliculus. Methods: Anterior segment spectral domain OCT images were collected prospectively from 9 lower puncta of 6 patients with epiphora and absent or fully occluded puncta, not amenable to dilation in clinic, to see if a canaliculus was visible on OCT imaging below the occluded punctum. Results: An epithelial lined canalicular lumen was visible on OCT in 4 ...

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      Mentions: Pearse A. Keane
    16. VISUAL FUNCTION CORRELATES OF FOVEAL SLOPE CHANGES ON OPTICAL COHERENCE TOMOGRAPHY IN MACULAR TELANGIECTASIA TYPE 2

      VISUAL FUNCTION CORRELATES OF FOVEAL SLOPE CHANGES ON OPTICAL COHERENCE TOMOGRAPHY IN MACULAR TELANGIECTASIA TYPE 2

      Purpose: To evaluate changes in foveal and parafoveal thickness measured using optical coherence tomography across five stages of macular telangiectasia 2 (MacTel 2) and to correlate the foveal slope angle with best-corrected visual acuity (BCVA). Methods: A multicentered, cross-sectional study of 90 patients with bilateral MacTel 2 was carried out. We reviewed medical records of patients who had undergone optical coherence tomography. Mean retinal thickness foveal and subfoveal were noted from ETDRS (Early Treatment Diabetic Retinopathy Study) mapping and later used for calculating foveal slope angle. The change in retinal thickness and foveal angle across five stages of MacTel 2 ...

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    17. NOVEL FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH TUBERCULAR SERPIGINOUS-LIKE CHOROIDITIS

      NOVEL FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH TUBERCULAR SERPIGINOUS-LIKE CHOROIDITIS

      Purpose: To analyze and describe the imaging characteristics of tubercular serpiginous-like choroiditis using optical coherence tomography angiography (OCTA) and to compare these findings with multimodal imaging. Methods: In this prospective cross-sectional study, multimodal imaging was performed in subjects with tubercular serpiginous-like choroiditis using OCTA (Optovue RTVue XR Avanti), enhanced-depth imaging OCT (Heidelberg Spectralis), fundus autofluorescence, fluorescein angiography, and indocyanine green angiography. Distinct morphologic features of the retinochoroidal vasculature at the sites of choroiditis lesions were analyzed on OCTA imaging. Multimodal imaging analysis was performed to study the changes observed on OCTA. Results: Eighteen eyes (18 subjects, 16 males) were included ...

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    18. Clinical Findings of Anterior Segment Spectral Domain Optical Coherence Tomography Images in Cytomegalovirus Corneal Endotheliitis

      Clinical Findings of Anterior Segment Spectral Domain Optical Coherence Tomography Images in Cytomegalovirus Corneal Endotheliitis

      Purpose: To evaluate the morphological characteristics of posterior corneal regions including keratic precipitates in eyes with cytomegalovirus (CMV) corneal endotheliitis using anterior segment spectral domain optical coherence tomography (SD-OCT). Methods: Thirteen eyes of 13 patients with polymerase chain reaction-proven CMV corneal endotheliitis were included in this study. Slit-lamp images and anterior segment SD-OCT images of the posterior cornea were obtained to analyze the clinical characteristics of corneal structures and keratic precipitates. Morphological changes in the posterior cornea throughout the course of an antiviral treatment were also investigated. Results: Anterior SD-OCT images showed protruding structures at the posterior cornea. These protruding ...

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    19. REPRODUCIBILITY OF VESSEL DENSITY MEASUREMENT WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH AND WITHOUT RETINOPATHY

      REPRODUCIBILITY OF VESSEL DENSITY MEASUREMENT WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH AND WITHOUT RETINOPATHY

      Purpose: To determine the intravisit and intervisit reproducibility of optical coherence tomography angiography measurements of macular vessel density in eyes with and without retinal diseases. Methods: Fifteen healthy volunteers and 22 patients with retinal diseases underwent repeated optical coherence tomography angiography (Angiovue Imaging System, Optovue Inc) scans after pupil dilation on 2 separate visit days. For each visit day, the eyes were scanned twice. Vessel density defined as the proportion of vessel area with flowing blood over the total measurement area was calculated using Angiovue software. Intravisit and intervisit reproducibility were summarized as coefficient of variations and intraclass correlation coefficients ...

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    20. 'Galahad' project to develop OCT for glaucoma diagnosis

      'Galahad' project to develop OCT for glaucoma diagnosis

      Multiple UK and Danish partners involved in €4M effort to develop high-res system based around supercontinuum source . Glaucoma: high-res imaging needed for diagnosis Gooch & Housego and NKT Photonics are among eight partners from the UK and Denmark who have just started work on a new €4 million European project to develop a high-resolution optical coherence tomography (OCT) system for glaucoma diagnosis. The “GALAHAD” (short for Glaucoma - Advanced, Label-free High Resolution Automated OCT Diagnosis) effort, funded through the European Commission’s Horizon 2020 innovation platform, officially kicked off this month and runs for three years. High-res requirements Current OCT systems offer ...

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    21. Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD

      Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD

      This comparative study between a SD- and SS-OCTA system for visualizing neovascular patterns in AMD, also assessed the influence of cataract on OCTA imaging. 25 eyes with active CNV (AMD) were documented by FA, ICGA and SD-OCT. Two OCTA devices were used: A custom built SS-OCTA (1050 nm, 400,000 A-scans/s, 5 × 5 mm, no image segmentation); AngioVue (OptoVue, CA, USA) SD-OCTA (840 nm, 70.000 A-scans/s, 3 × 3 mm, SSADA technology). Two retina experts graded CNV types and vascular patterns. Cataract influence on OCTA image quality was reported for the superficial retinal plexus (6 eyes). The SS-OCTA ...

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    22. Optical coherence tomography in glaucoma-I

      Optical coherence tomography in glaucoma-I

      It is a well-established fact that more than 40% ganglion cells are lost before the white-on-white perimetry shows defects. Hence, the importance of modalities which can image the structures of optic nerve and surrounding retinal nerve fiber layer in the early diagnosis of glaucoma cannot be overemphasized. However, the appropriate interpretation of these imaging modalities is of paramount importance. Out of the three machines such as HRT, scanning laser polarimeter (GDx VCC), and the OCT, the OCT has made a remarkable progress and can be incorporated judiciously in the clinical practice of glaucoma management. The purpose of this article is ...

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    23. Spectralis optical coherence tomography normal macular thickness in Egyptians

      Spectralis optical coherence tomography normal macular thickness in Egyptians

      Purpose The aim of this study was to determine the normative data of macular thickness in the Egyptian population and to assess the effect of different demographic data and ocular parameters on it using spectral-domain optical coherence tomography (SD-OCT). Patients and methods This cross-sectional study included 105 healthy Egyptian patients who underwent a comprehensive ophthalmic examination, including Spectralis SD-OCT scanning, at Alexandria Main University Hospital. One eye from each patient was chosen randomly to be included in the study. Macular thickness was calculated based on center thickness and nine areas that corresponded to the Early Treatment Diabetes Retinopathy Study map ...

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    24. To Study and Determine the Role of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in Corneal and Conjunctival Tumors

      To Study and Determine the Role of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in Corneal and Conjunctival Tumors

      Purpose . To analyze and describe corneal and conjunctival tumor thickness and internal characteristics and extension in depth and size and shape measured by two noninvasive techniques, anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Design . Systematic review. Methods . This systematic review is based on a comprehensive search of 4 databases (Medline, Embase, Web of Science, and Cochrane Library). Articles published between January 1, 1999, and December 31, 2015, were included. We searched for articles using the following search terms in various combinations: “optical coherence tomography”, “ultrasound biomicroscopy”, “corneal neoplasm”, “conjunctival neoplasm”, “eye”, “tumor” and “anterior segment tumors”. Inclusion ...

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