1. Articles in category: Ophthalmology

    577-600 of 8134 « 1 2 ... 22 23 24 25 26 27 28 ... 337 338 339 »
    1. Method for measuring an eye

      Method for measuring an eye

      A method for measuring the axial length of an eye using optical coherence tomography, during which a plurality of A-scans of the OCT measurement are combined to an axial length, taking into account the alignment with which they were obtained, and taking into account the topography of the cornea. The distance of the front of the cornea from the retina is determined using OCT while measuring or controlling the alignment of the measuring device to the eye in that the topography of the front of the cornea is measured or made available. The calculation of an axial length from an ...

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    2. Uveo-scleral outflow pathways after ultrasonic cyclocoagulation in refractory glaucoma: an anterior segment optical coherence tomography and in vivo confocal study

      Uveo-scleral outflow pathways after ultrasonic cyclocoagulation in refractory glaucoma: an anterior segment optical coherence tomography and in vivo confocal study

      Aims To evaluate, using anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM), the uveo-scleral aqueous humour (AH) outflow pathways after ultrasonic circular cyclocoagulation (UCCC). Methods Forty-four patients with refractory glaucoma underwent 4 or 6 s UCCC (group 1, 24 eyes; group 2, 20 eyes). UCCC was successful when the preoperative intraocular pressure (IOP) reduced by one-third. AS-OCT and IVCM were performed at baseline and at month 1 to evaluate the sclera and conjunctiva. The main outcomes were mean intra-scleral hyporeflective spaces area (MIHSA: mm 2 ) at AS-OCT, mean density and area of conjunctival microcysts (MMD: cysts ...

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    3. The use of macular optical coherence tomography thickness in the diagnosis and follow-up of glaucoma

      The use of macular optical coherence tomography thickness in the diagnosis and follow-up of glaucoma

      Glaucoma is the leading cause of irreversible blindness worldwide. Glaucoma optic neuropathy results in the death of retinal ganglion cells, which are most densely populated in the macular region with 30% of the total number of these cells occupying only 2% of the retina's area. On the basis of this anatomic relationship, Zeimer and colleagues 1 reported large losses in total macular thickness in patients with known glaucomatous damage. Recent data suggest that glaucoma affects the macular thickness early in its course.

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    4. Correlation of spectral domain optical coherence tomography findings in sub-silicone oil foveal depression space and visual outcomes in eyes undergoing silicone oil removal

      Correlation of spectral domain optical coherence tomography findings in sub-silicone oil foveal depression space and visual outcomes in eyes undergoing silicone oil removal

      Background/Purpose To describe small hyper-reflective spherical bodies in sub-silicone oil-foveal depression (SSO-FD) space using spectral domain optical coherence tomography (SD-OCT) and its effect on visual outcomes in eyes undergoing silicone oil removal (SOR). Methods This was a prospective interventional comparative study comprising 42 eyes undergoing SOR with clear media. All patients underwent detailed clinical examination and SD-OCT scan of fovea preoperatively and at 30 days and 90 days postoperatively. Patients were divided into Group A ( n = 21) and Group B ( n = 21) depending on presence or absence, respectively, of small hyper-reflective spherical bodies in the SSO-FD space in preoperative ...

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    5. Optovue’s AngioVue Imaging System Receives FDA Clearance

      Optovue’s AngioVue Imaging System Receives FDA Clearance

      Optovue, the global leader in the development and commercialization of optical coherence tomography angiography (OCTA), today announced FDA clearance and immediate U.S. commercial availability of the AngioVue™** Imaging System, a groundbreaking technology that provides a non-invasive way to visualize abnormal blood vessels to help physicians determine an appropriate course of treatment. “We are thrilled to announce FDA clearance of our AngioVue System, which will bring the significant benefits of our innovative, non-invasive retinal imaging to patients in the U.S. who suffer from retinal diseases that lead to progressive blindness,” said Jay Wei, founder and chief executive officer at ...

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      Mentions: Optovue Jay Wei FDA
    6. Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000

      Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000

      Background Optical coherence tomography (OCT), can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance. Methods Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. Repeatability was evaluated by use of the coefficient of repeatability (CR) and the coefficient of repeatability as a percentage of the mean (CR ...

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    7. Glaucoma Tube Changes After Suture Lysis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography

      Glaucoma Tube Changes After Suture Lysis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography

      This Ophthalmic Image shows swept-source optical coherence tomography of glaucoma tube changes after Baerveldt glaucoma implant into the ciliary sulcus. A woman developed Takayasu disease and neovascular glaucoma in her early 20s. She underwent cardiovascular bypass surgery, but lost vision in her left eye. When another cardiovascular bypass was planned in her mid-40s, 95% of her right eye angle was closed, but her intraocular pressure (IOP) did not exceed the high teens while receiving glaucoma medications, probably because of reduced ocular circulation. 1 In preparation for the IOP increase with circulation improvement, we performed a Baerveldt glaucoma implant into the ...

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    8. Characteristics and Limitations of Intraoperative OCT Supported Membrane Peeling in Macular Diseases

      Characteristics and Limitations of Intraoperative OCT Supported Membrane Peeling in Macular Diseases

      During the last decade optical coherence tomography (OCT) extended the possibilities for in vivo macula diagnostic and was increasingly used for pre- and post-operative imaging of retinal diseases. Spectral-domain optical coherence tomography (SD-OCT) with its increased scanning speed and image-resolution provides more detailed information of microstructures in the macula. Epiretinal membrane (ERM), pseudomaculaforamen, maculaforamen and vitreomacular traction syndrome are disorders involving the posterior pole of the eyeball with consecutive vision loss. In patients with loss of vision and metamorphopsia disturbing their lifestyle, vitrectomy and membrane peeling is usually performed to remove traction and the ERM. Different study groups showed that ...

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    9. Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration

      Purpose To determine whether angiography with swept-source (SS) optical coherence tomography (OCT) identifies subclinical type 1 neovascularization in asymptomatic eyes with intermediate age-related macular degeneration (iAMD). Design Prospective, observational, consecutive case series. Participants Patients with asymptomatic iAMD in one eye and neovascular age-related macular degeneration (AMD) in their fellow eye. Methods The patients underwent SS OCT angiography (OCTA), fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the images from these 3 angiographic techniques were compared. Main Outcome Measures Identification of subclinical type 1 neovascularization with SS OCTA in asymptomatic eyes with iAMD. Results Eleven consecutive patients with iAMD in ...

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    10. The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT

      The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT

      Purpose To determine whether retinal nerve fiber layer (RNFL), macula and macular ganglion cell layer (mGCL)-inner plexiform layer (IPL) thickness differ in the amblyopic and normal fellow eyes of unilateral amblyopic patients using spectral domain optical coherence tomography (SD-OCT). Methods 80 patients with 160 eyes were included in this study; the distribution of patients was 17 patients with strabismic amblyopia, 17 patients with strabismic non-amblyopia, 23 patients with anisometropic amblyopia, and 23 patients with anisometropic non-amblyopia. Macular, RNFL, and mGCL-IPL thickness were obtained by SD-OCT, and the interocular thickness differences of each group were analyzed. After treatment, the changes ...

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    11. Macular Choroidal Thickness and Volume Measured by Swept-source Optical Coherence Tomography in Healthy Korean Children

      Macular Choroidal Thickness and Volume Measured by Swept-source Optical Coherence Tomography in Healthy Korean Children

      Purpose To evaluate the thickness and volume of the choroid in healthy Korean children using swept-source optical coherence tomography. Methods We examined 80 eyes of 40 healthy children and teenagers (<18 years) using swept-source optical coherence tomography with a tunable long-wavelength laser source. A volumetric macular scan protocol using the Early Treatment Diabetic Retinopathy Study grid was used to construct a choroidal thickness map. We also examined 44 eyes of 35 healthy adult volunteers (≥18 years) and compared adult measurements with the findings in children. Results The mean age of the children and teenagers was 9.47 ± 3.80 (4 ...

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    12. Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis

      Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis

      Purpose To analyze the structural and morphological characteristics of retinal astrocytic hamartomas in tuberous sclerosis patients using fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography. Case summary Fundus examination, fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography were performed in three patients with tuberous sclerosis and the morphological and structural characteristics of retinal astrocytic hamartomas were analyzed. In the fundus autofluorescence, type 1 retinal astrocytic hamartoma showed hypofluorescence and type 3 showed central hyperfluorescence and surrounding hypofluorescence. Spectral domain optical coherence tomography showed dome-shaped hyper-reflectivity within the nerve fiber layer and focal adhesion of the vitreous cortex in ...

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    13. Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems

      Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems

      PURPOSE: To compare corneal thickness measurements between three imaging systems. METHODS: In this retrospective study of 81 virgin and 58 post-laser refractive surgery corneas, central and minimum corneal thickness were measured using optical coherence tomography (OCT), very high-frequency digital ultrasound (VHF digital ultrasound), and a Scheimpflug imaging system. Agreement between methods was analyzed using mean differences (bias) (OCT – VHF digital ultrasound, OCT – Scheimpflug, VHF digital ultrasound – Scheimpflug) and Bland–Altman analysis with 95% limits of agreement (LoA). RESULTS: Virgin cornea mean central corneal thickness was 508.3 ± 33.2 µ m (range: 434 to 588 µ m) for OCT, 512.7 ± 32 ...

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    14. Repeatability and Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements of Retinal Thickness in Rats

      Repeatability and Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements of Retinal Thickness in Rats

      Purpose : To evaluate the in vivo repeatability and reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurements of total retinal thickness (TRT) and retinal nerve fiber layer (RNFL) thickness in rats. Methods : Retinal thickness was measured using an RNFL circular scan with AutoRescan and TruTracking modes in 20 eyes of Long-Evans Tokushima Otsuka rats. Three RNFL circular scan images were acquired with a brief rest between measurements to evaluate intra-session repeatability. Three additional RNFL circular scans were acquired 1 day later to evaluate intersession repeatability. Two experienced examiners independently measured TRT using automatic alignment and RNFL thickness using manual alignment according ...

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    15. Macular Thickness in Myopia: An OCT Study of Young Chinese Patients

      Macular Thickness in Myopia: An OCT Study of Young Chinese Patients

      Purposes : To investigate macular thickness (MT) in young myopic Chinese patients using Spectralis optical coherence tomography (OCT) and to assess its association with gender, axial length (AL), spherical equivalent (SE), and intraocular pressure (IOP). Methods : Included in this study were 133 myopic Chinese patients, aged 18–30 years. All underwent complete ophthalmic examinations and Spectralis OCT. Inner, central, and outer foveal regions of the macula were measured. Results : The central fovea was the thinnest of the three macular regions (mean thickness, 250.1 ± 15.3 μm). Women had consistently thinner MTs than did men, except in the outer superior and ...

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    16. A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      Purpose/Aim : Pseudotumor cerebri, or idiopathic intracranial hypertension (IIH), is characterized by increased intracranial pressure of unknown etiology. A subset of patients has shown benefit from endovascular dural venous sinus stenting (DVSS). We sought to identify a population of IIH patients who underwent DVSS to assess outcomes. Materials and Methods : A retrospective study was performed to identify IIH patients with dural sinus stenosis treated with DVSS. Outcome measures included dural sinus pressure gradients, peripapillary retinal nerve fiber layer thickness using optical coherence tomography, and improvement in symptoms. Results : Seventeen patients underwent DVSS. Average pre- and post-intervention pressure gradients were 23 ...

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    17. Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Purpose To investigate the profile and determinants of retinal optical intensity in normal subjects using 3D spectral domain optical coherence tomography (SD OCT). Methods A total of 231 eyes from 231 healthy subjects ranging in age from 18 to 80 years were included and underwent a 3D OCT scan. Forty-four eyes were randomly chosen to be scanned by two operators for reproducibility analysis. Distribution of optical intensity of each layer and regions specified by the Early Treatment of Diabetic Retinopathy Study (ETDRS) were investigated by analyzing the OCT raw data with our automatic graph-based algorithm. Univariate and multivariate analyses were ...

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    18. Zeiss AngioPlex Optical Coherence Tomography Angiography of the Retinal Microvasculature May Help Enhance Understanding of Retinal Diseas

      Zeiss AngioPlex Optical Coherence Tomography Angiography of the Retinal Microvasculature May Help Enhance Understanding of Retinal Diseas

      AngioPlexTM optical coherence tomography (OCT) is a new approach to diagnostic imaging in retinal disease. This technology uses amplitude and phase aspects of the OCT signal and novel algorithms to enable highly detailed visualisation of the retinal microvasculature. This system detects capillary flow rather than the presence of an injected dye. Unlike fluorescein angiography (FA), AngioPlex OCT imaging can discriminate capillaries at the superficial and deep retina and can also generate a colour map of the retinal vessels providing unparalleled views of diseased capillaries and net structures. Retinal and choroidal pathologies that are amenable to AngioPlex OCT examination include diabetic ...

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      Mentions: FDA
    19. Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Background: A cross-sectional study to investigate the morphological and functional changes of the visual pathway, taking place in patients with migraine. Methods: Fifteen patients (14 female, 1 male) diagnosed with migraine with aura (MA group) and 23 patients (21 female, 2 male) diagnosed with migraine without aura (MO group) were compared to 20 healthy volunteers (18 Female, 2 male). All the participants underwent optical coherence tomography (OCT) scan, electroretinogram (ERG), visual evoked potentials (VEP), and multifocal electroretinogram (mf-ERG) recording. Results: Assessing ERG recordings, no significant differences in mean N1-P1 amplitudes were measured among the groups. The mean VEP N80-P100 amplitudes ...

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    20. Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography

      Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography

      AIM : To assess quantitative changes of the macula in diabetic eyes after cataract surgery using optical coherence tomography (OCT) and to estimate the incidence of development or worsening of macular edema (ME) in diabetic eyes with or without pre-existing ME. METHODS : In this prospective, observational study, 92 eyes of 60 diabetic patients who underwent cataract surgery were evaluated before surgery and 1, 3mo after surgery using OCT. Macular thickness was measured with OCT at nine macular subfields defined by the 9 zones early treatment of diabetic retinopathy study (ETDRS), as well as total macular volume obtained by OCT at 1 ...

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    21. Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

      Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

      Dear Sir, I write to present the correlation between microperimetric (MP) values and the density of myelinated retinal nerve fibers (MNFs) in optical coherence tomography (OCT) imaging. MNFs appear as white or gray-white striated patches that correspond in shape to the distribution of retinal nerve fibers and demonstrate frayed borders[1] . Visual system myelination normally begins at the optic tracts at 7mo of gestational age and progresses anteriorly, finishing within 3mo after birth and stopping at the lamina cribrosa. However, this process may progress beyond this level and cause retinal nerve fibers to become myelinated [2-4] . The incidence of MNFs ...

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    22. Optical Coherence Tomography Angiography of the Retinal Microvasculature using the Zeiss AngioPlex

      Optical Coherence Tomography Angiography of the Retinal Microvasculature using the Zeiss AngioPlex

      AngioPlex optical coherence tomography (OCT) is a new approach to diagnostic imaging in retinal disease. This technology uses amplitude and phase aspects of the OCT signal and novel algorithms to enable highly detailed visualisation of the retinal microvasculature. This system detects capillary flow rather than the presence of an injected dye. Unlike fluorescein angiography (FA), AngioPlex OCT imaging can discriminate capillaries at the superficial and deep retina and can also generate a colour map of the retinal vessels providing unparalleled views of diseased capillaries and net structures. Retinal and choroidal pathologies that are amenable to AngioPlex OCT examination include diabetic ...

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      Mentions: FDA
    23. Retinal Imaging Techniques for Diabetic Retinopathy Screening

      Retinal Imaging Techniques for Diabetic Retinopathy Screening

      Due to the increasing prevalence of diabetes mellitus, demand for diabetic retinopathy (DR) screening platforms is steeply increasing. Early detection and treatment of DR are key public health interventions that can greatly reduce the likelihood of vision loss. Current DR screening programs typically employ retinal fundus photography, which relies on skilled readers for manual DR assessment. However, this is labor-intensive and suffers from inconsistency across sites. Hence, there has been a recent proliferation of automated retinal image analysis software that may potentially alleviate this burden cost-effectively. Furthermore, current screening programs based on 2-dimensional fundus photography do not effectively screen for ...

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    24. A pilot study to image the vascular network of small melanocytic choroidal tumors with speckle noise-free 1050-nm swept source optical coherence tomography (OCT choroidal angiography)

      A pilot study to image the vascular network of small melanocytic choroidal tumors with speckle noise-free 1050-nm swept source optical coherence tomography (OCT choroidal angiography)

      Purpose To visualize and measure the vascular network of melanocytic choroidal tumors with speckle noise-free swept source optical coherence tomography (SS-OCT choroidal angiography). Methods Melanocytic choroidal tumors from 24 eyes were imaged with 1050-nm optical coherence tomography (Topcon DRI OCT-1 Atlantis). A semi-automated algorithm was developed to remove speckle noise and to extract and measure the volume of the choroidal vessels from the obtained OCT data. Results In all cases, analysis of the choroidal vessels could be performed with SS-OCT without the need for pupillary dilation. The proposed method allows speckle noise-free, structure-guided visualization and measurement of the larger choroidal ...

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