1. Articles in category: Ophthalmology

    577-600 of 6591 « 1 2 ... 22 23 24 25 26 27 28 ... 273 274 275 »
    1. Optical coherence tomography derived corneal thickness asymmetry indices: Clinical reference study of normal eyes

      Optical coherence tomography derived corneal thickness asymmetry indices: Clinical reference study of normal eyes

      Purpose To determine 3-dimensional corneal pachymetry distribution characteristics in a large pool of healthy normal patients. Setting Private practice, Athens, Greece. Design Prospective case series. Methods Spectral-domain anterior segment optical coherence tomography (AS-OCT) was used for measurements of central (CCT) and minimum corneal thickness, thickness asymmetry indices for superonasal–inferotemporal (SN–IT) and superior–inferior (S–I), and focal thinning indices (Min–Med focal thinning, Min–Max thickness range). Results The study enrolled 561 eyes. The mean values were CCT, 537.17 μm ± 30.99 (SD) (range 447.0 to 654.0 μm); minimum corneal thickness, 529.01 ± 30.02 ...

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    2. Comparison of iridocorneal angle in infants with retinopathy of prematurity and healthy infants using spectral domain optical coherence tomography

      Comparison of iridocorneal angle in infants with retinopathy of prematurity and healthy infants using spectral domain optical coherence tomography

      Purpose To compare measurements and morphologic characteristics of the iridocorneal angle in preterm infants with retinopathy of prematurity (ROP) and healthy infants using spectral domain optical coherence tomography (SD-OCT). Methods In this observational, case–control study, the eyes of children with ROP and healthy controls under 1 year old were imaged using SD-OCT without sedation to capture the iridocorneal angle. The ROP staging was made by a pediatric retinal specialist. The following measurements were analyzed with custom software: angle opening distance (AOD 500 ) at 500 μm; angle opening in degrees (AOG); and angle recess area (ARA 750 ). Results A total ...

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    3. Megalopapilla in children: a spectral domain optical coherence tomography analysis

      Megalopapilla in children: a spectral domain optical coherence tomography analysis

      Purpose To compare various optic nerve head (ONH) parameters and peripapillary retinal nerve fibre layer (pRNFL) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (SD-OCT) in children. Methods Fifty eyes with megalopapilla and 80 normal control eyes of totally 130 children between the ages of 6 and 15 were examined using SD-OCT. Optic nerve head parameters including disc diameter, cup-to-disc ratio, disc area, cup area, rim area, cup volume and rim volume, and pRNFL thickness were analysed and compared between two groups. Results Megalopapilla group presented larger optic disc diameter, disc and cup area, cup-to-disc ...

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    4. Fractal-based analysis of optical coherence tomography data to quantify retinal tissue damage

      Fractal-based analysis of optical coherence tomography data to quantify retinal tissue damage

      Background The sensitivity of Optical Coherence Tomography (OCT) images to identify retinal tissue morphology characterized by early neural loss from normal healthy eyes is tested by calculating structural information and fractal dimension. OCT data from 74 healthy eyes and 43 eyes with type 1 diabetes mellitus with mild diabetic retinopathy (MDR) on biomicroscopy was analyzed using a custom-built algorithm (OCTRIMA) to measure locally the intraretinal layer thickness. A power spectrum method was used to calculate the fractal dimension in intraretinal regions of interest identified in the images. ANOVA followed by Newman-Keuls post-hoc analyses were used to test for differences between ...

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    5. Characterization of macular thickness changes in Leber's hereditary optic neuropathy by optical coherence tomography

      Characterization of macular thickness changes in Leber's hereditary optic neuropathy by optical coherence tomography

      Background To characterize macular thickness (MT) changes in Leber's hereditary optic neuropathy (LHON) patients by cirrus HD-optical coherence tomography (OCT), and to study the correlation between MT and best corrected visual acuity (BCVA). Methods Fifty-two eyes from 52 consecutive LHON patients and 14 eyes from 14 age- and sex-matched healthy controls were scanned by OCT. Affected eyes were classified into five groups according to disease duration (1st group: <=3 months; 2nd group: 3-6 months; 3rd group: 6-9 months; 4th group: 9-12 months; and 5th group: >12 months). MT was compared and analyzed. The correlation between BCVA and MT was ...

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    6. Morphometric analysis of fovea with spectral-domain optical coherence tomography and visual outcome postsurgery for retinal detachment

      Morphometric analysis of fovea with spectral-domain optical coherence tomography and visual outcome postsurgery for retinal detachment

      The purpose of this study was to correlate the postoperative best-corrected visual acuity (BCVA) with spectral-domain optical coherence tomography (SD-OCT) findings in fovea involving rhegmatogenous retinal detachment (RRD) surgery. Materials and Methods: Thirty eyes with preoperative fovea-involving RRD, who underwent scleral buckling (SB) (6 eyes) and pars plana vitrectomy (PPV) (19 eyes) and combined SB and PPV (5 eyes) were recruited. Patients underwent clinical examination and SD-OCT scan of fovea preoperatively and at 30 days and 90 days postoperatively. The correlations between SD-OCT findings and BCVA were analyzed. Results: Inner segment/outer segment (IS/OS) junction integrity was the indicator ...

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    7. Improved User Interface For Acquistion, Display And Analysis Of Ophthalmic Diagnostic Data

      Improved User Interface For Acquistion, Display And Analysis Of Ophthalmic Diagnostic Data

      Improvements to user interfaces for ophthalmic imaging systems, in particular Optical Coherence Tomography (OCT) systems are described to improve how diagnostic data are displayed, analyzed and presented to the user. The improvements include user customization of display and reports, protocol driven work flow, bookmarking of particular B-scans, accessing information from a reference library, customized normative databases, and ordering of follow-up scans directly from a review screen.

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    8. Systems And Methods For Variable Mode Optical Coherence Tomography Imaging

      Systems And Methods For Variable Mode Optical Coherence Tomography Imaging

      Systems and methods for improvements to optical coherence tomography systems for operating in different imaging modes are presented. In one embodiment, a system for identifying the presence and type of an adjunct lens operably connected to the OCT instrument for changing between imaging modes in the system is described. In a second embodiment, a system for dynamically autofocusing the OCT system depending on the layer of interest is presented.

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    9. System And Method For Ophthalmic Laser Surgery Employing Eye Tracking Without Eye Docking

      System And Method For Ophthalmic Laser Surgery Employing Eye Tracking Without Eye Docking

      A system and method for performing ophthalmic surgery using an ultra-short pulsed laser is provided. The system includes a laser engine configured to provide an ultra-short pulsed laser beam, optics configured to direct the laser beam to an undocked eye of a patient, an eye tracker configured to measure five degrees of freedom of movement of the undocked eye, an optical coherence tomography module configured to measure depth of the undocked eye, and a controller configured to control laser beam position on the undocked eye toward a desired laser pattern based on depth and the five degrees of freedom of ...

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    10. Spectral-domain optical coherence tomography findings in polypoidal choroidal vasculopathy suggest a type 1 neovascular growth pattern

      Spectral-domain optical coherence tomography findings in polypoidal choroidal vasculopathy suggest a type 1 neovascular growth pattern

      Purpose: To report spectral-domain optical coherence tomography (SD-OCT) findings in polypoidal choroidal vasculopathy (PCV). Patients and methods: Seventeen eyes of 15 consecutive patients diagnosed with PCV based on typical clinical and angiographic findings were imaged with macular SD-OCT including line scans passing through the polyps. Results: SD-OCT findings included typical and atypical retinal pigment epithelial (RPE) detachments and subretinal and intraretinal fluid in all eyes. In the areas corresponding to the polypoidal lesions, well-delineated round-oval, sub-RPE cavities were present and were adherent to the posterior surface of the detached RPE above Bruch membrane. No retinal or choroidal connections to the ...

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    11. Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

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    12. Predictive Values of Optical Coherence Tomography (OCT) Parameters in Assessment of Glaucoma progression

      Predictive Values of Optical Coherence Tomography (OCT) Parameters in Assessment of Glaucoma progression

      Goal: the purpose of the current study was to estimate the predictive values of optical coherence tomography parameters in early, developed perimetric and terminal glaucoma. Methods: 180 eyes of 120 consecutive patients were evaluated in this retrospective cross sectional pilot study. Copernicus Spectral –domain optical coherence tomography with resolution of 3 mm obtained throught the optic nerve head were included. All examined eyes were divided to four groups (healthy,early, developed perimetric glaucoma and terminal glaucoma). The values of the thicknes of the retinal nerve fibre layer, the size of the disk, the volume of the cup, the E/D ...

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    13. Analysis of peripapilary retinal nerve fiber layer thickness of healthy Chinese from northwestern Shanghai using Cirrus HD-OCT

      Analysis of peripapilary retinal nerve fiber layer thickness of healthy Chinese from northwestern Shanghai using Cirrus HD-OCT

      AIM: To investigate peripapillary retinal nerve fiber layer (RNFL) thickness of healthy Chinese individuals from northwestern Shanghai using Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA, USA). METHODS: The peripapillary RNFL thickness of 720 eyes from 360 healthy Chinese participants were measured using the Optic Disc Cube 200×200 protocol. Each eye was scanned 3 times. Global and each quadrant’s RNFL thickness around the optic nerve were compared between genders, and interocular differences were analyzed. The correlation between global RNFL thickness and age were also assessed in this study. RESULTS: The mean global, superior, nasal, inferior and temporal RNFL ...

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    14. OPTICAL COHERENCE TOMOGRAPHIC HYPERREFLECTIVE FOCI IN EARLY STAGES OF DIABETIC RETINOPATHY

      OPTICAL COHERENCE TOMOGRAPHIC HYPERREFLECTIVE FOCI IN EARLY STAGES OF DIABETIC RETINOPATHY

      Purpose: To analyze the presence of hyperreflective foci in Type 1 and Type 2 diabetic patients, separately, without clinically significant diabetic macular edema and visual impairment. Methods: Noninvasive, observational prospective study. Seventeen and 19 consecutive Type 1 and Type 2 diabetic patients (33 and 38 eyes), respectively, were recruited. All patients had no clinically significant diabetic macular edema or visual impairment. Two age- and sex-matched control groups were also included. Patients underwent an ophthalmologic examination including spectral domain optical coherence tomography. Hyperreflective foci were counted considering horizontal B-scan passing through the fovea. Results: On spectral domain optical coherence tomography, patients ...

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    15. OPTICAL COHERENCE TOMOGRAPHY-GUIDED RANIBIZUMAB INJECTION FOR CYSTOID MACULAR EDEMA IN WELL-CONTROLLED UVEITIS: Twelve-Month Outcomes

      OPTICAL COHERENCE TOMOGRAPHY-GUIDED RANIBIZUMAB INJECTION FOR CYSTOID MACULAR EDEMA IN WELL-CONTROLLED UVEITIS: Twelve-Month Outcomes

      Purpose: To determine whether serial ranibizumab injections are effective in the treatment of cystoid macular edema in patients with chronic controlled noninfectious uveitis. Methods: Five eyes of 5 patients were included in a prospective noncomparative therapeutic trial. They received intravitreal injections of ranibizumab at Day 0 and were followed monthly for 1 year. Injections were repeated monthly if persistent or new cystic edema manifested on optical coherence tomography. The primary outcome measure was the mean change in best-corrected visual acuity from baseline at 12 months. Secondary outcome measures included mean percentage change in central subfield retinal thickness (CST) and incidence ...

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    16. Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis

      Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis

      Background Macular edema is a common cause of visual loss at uveitic patients. The aim of our study was to investigate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis and in healthy individuals using spectral domain optical coherence tomography (SD-OCT). Methods Case-control study of 21 patients with AU and 23 patients with IMU and 34 age-matched healthy controls was performed with Spectralis SD-OCT (Heidelberg Engineering, Germany). High resolution SD-OCT scans and macular mapping were applied for automated measurement of retinal thickness. Standardized, masked manual measurement of the choroidal thickness was performed in the center ...

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    17. Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu wants to figure out how to peer into your soul . . . or at least your brain. An expert in designing computer image processing algorithms, Farsiu is an assistant professor of ophthalmology at Duke Medicine who recently accepted a primary appointment in the Pratt biomedical engineering department with the hopes of strengthening collaborations across the university. “When President Bush said he looked Vladimir Putin in the eye and got a sense of his soul, he was actually on to something,” said Farsiu, who has a long history of collaborating with peers in Duke’s engineering school. “The retina is part ...

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    18. OCT in the Management of Macular Degeneration - Ophthalmology Education Lab

      OCT in the Management of Macular Degeneration - Ophthalmology Education Lab

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

      Read Full Article
    19. Software Postdoctoral Position in Optical imaging at Casey Eye Institute, Oregon Health & Science University

      Software Postdoctoral Position in Optical imaging at Casey Eye Institute, Oregon Health & Science University

      The Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University, is seeking outstanding candidates for the following position in optical imaging research in the field of ophthalmology. Post-Doc (software): optical signal processing, image processing Requirements: PhD degree in a relevant discipline (Biomedical Engineering, Medical Physics, computer science, applied mathematics) is required. Solid background in optical signal processing, (medical) image analysis, segmentation and/or image registration are essential. Experiences in imaging (scanning laser ophthalmoscopy, angiography, microscopy, oximetry, adaptive optics), and software development (GPU programming) are also desirable. The successful candidate will be supervised by ...

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    20. Corneal Topographic Analysis of Patients With Mooren Ulcer Using 3-Dimensional Anterior Segment Optical Coherence Tomography

      Corneal Topographic Analysis of Patients With Mooren Ulcer Using 3-Dimensional Anterior Segment Optical Coherence Tomography

      Purpose: To investigate the corneal topography and visual function of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography (3-D AS-OCT). Methods: Fourteen eyes of 9 patients with Mooren ulcer were studied. Pachymetric and axial power maps were obtained by 3-D AS-OCT. The axial power maps were classified into 3 patterns by visual inspection. The distribution of the corneal dioptric power was analyzed by Fourier harmonic expansion. The magnitudes of the spherical component, asymmetry, regular astigmatism, higher-order irregularity, and radial distance from the corneal vertex to the thinnest point of the lesion were determined. Results: The axial power ...

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