1. Articles in category: Ophthalmology

    577-600 of 7816 « 1 2 ... 22 23 24 25 26 27 28 ... 324 325 326 »
    1. Capillary Network Anomalies In Branch Retinal Vein Occlusion On Optical Coherence Tomography Angiography

      Capillary Network Anomalies In Branch Retinal Vein Occlusion On Optical Coherence Tomography Angiography

      Purpose: To analyze the foveal microvasculature features in eyes with branch retinal vein occlusion (BRVO) using optical coherence tomography angiography based on split spectrum amplitude decorrelation angiography technology. Methods: A total of 10 BRVO eyes (mean age 64.2 ± 8.02 range between 52 years and 76 years) were evaluated by optical coherence tomography angiography (XR-Avanti; Optovue). The macular angiography scan protocol covered a 3 mm × 3 mm area. The focus of angiography analysis were two retinal layers: superficial vascular network and deep vascular network. The following vascular morphological congestion parameters were assessed in the vein occlusion area in both ...

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    2. NONINVASIVE GRADING OF RADIATION RETINOPATHY: The Use of Optical Coherence Tomography Angiography

      NONINVASIVE GRADING OF RADIATION RETINOPATHY: The Use of Optical Coherence Tomography Angiography

      Purpose: Previous studies have shown that spectral domain optical coherence tomography can diagnose radiation retinopathy (RR) before ophthalmoscopic findings. Recently, optical coherence tomography angiography (OCT-A) has been helpful in seeing vascular findings undetected by spectral domain optical coherence tomography. The authors wish to demonstrate the OCT-A grading at varying levels of RR. Methods: The OCT-A, spectral domain optical coherence tomography, and ophthalmoscopic findings on 7 patients from December 2014 to March 2015 with varying levels of RR are demonstrated. Results: Findings on OCT-A could be demonstrated before spectral domain optical coherence tomography findings. Patients can be graded on a scale ...

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    3. Leading Edge Collaboration in Eye-Related Research Earns Investigators at NYU Langone Medical Center, Johns Hopkins, and the UT Southwestern Medical Center the 2015 Barancik Prize for Innovation in MS Research

      Leading Edge Collaboration in Eye-Related Research Earns Investigators at NYU Langone Medical Center, Johns Hopkins, and the UT Southwestern Medical Center the 2015 Barancik Prize for Innovation in MS Research

      The collaborative team of Drs. Laura Balcer , Peter Calabresi and Elliot Frohman have been selected as the winners of the 2015 Barancik Prize for Innovation in MS Research. This team of physician-scientists have worked together for almost 10 years to produce novel, ground-breaking and impactful research about the anatomy and biology of the retina and other structures of the eye in people with multiple sclerosis (MS). In their more than 50 publications, the team has literally "written the book" when it comes to applying optical coherence tomography (OCT), a common and easy-to-use eye scanning technique, to study MS. Thanks in ...

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    4. A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography

      A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography

      Objective To test the feasibility of using frequency-domain optical coherence tomography (FD-OCT) and a region-of-interest (ROI) approach to measure progressive changes in glaucomatous damage. Design, Setting, and Participants Among a group of patients in an institutional glaucoma practice who were likely to show glaucoma progression, eyes with a history of an optic disc hemorrhage (DH) confirmed by stereophotography were followed up with FD-OCT cube scans of the optic disc. All patients underwent FD-OCT scans on at least 2 occasions separated by at least 1 year (mean, 3.45 years; range, 1.42-6.39 years). Because we were not studying the ...

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    5. OPTIC NERVE HEAD SEGMENTATION USING FUNDUS IMAGES AND OPTICAL COHERENCE TOMOGRAPHY IMAGES FOR GLAUCOMA DETECTION

      OPTIC NERVE HEAD SEGMENTATION USING FUNDUS IMAGES AND OPTICAL COHERENCE TOMOGRAPHY IMAGES FOR GLAUCOMA DETECTION

      Background: Glaucoma is a common causes of blindness. The associated elevation in intra ocular pressure leads to progressive degeneration of the optic nerve and resultant structural changes with functional failure of the visual field. Since, glaucoma is asymptomatic in the early stages and the associated vision loss is irreparable, its early detection and timely medical treatment is essential to prevent further visual damage. Objective: This paper presents a novel method for glaucoma detection using digital fundus image and optical coherence tomography (OCT) image. Method: The first section focuses on the features such as cup to disc ratio (CDR) and the ...

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    6. A Diagnostic Calculator for Detecting Glaucoma on the Basis of Retinal Nerve Fiber Layer, Optic Disc, and Retinal Ganglion Cell Analysis by Optical Coherence Tomography

      A Diagnostic Calculator for Detecting Glaucoma on the Basis of Retinal Nerve Fiber Layer, Optic Disc, and Retinal Ganglion Cell Analysis by Optical Coherence Tomography

      Purpose : The purpose of this study was to develop and validate a multivariate predictive model to detect glaucoma by using a combination of retinal nerve fiber layer (RNFL), retinal ganglion cell-inner plexiform (GCIPL), and optic disc parameters measured using spectral-domain optical coherence tomography (OCT). Methods : Five hundred eyes from 500 participants and 187 eyes of another 187 participants were included in the study and validation groups, respectively. Patients with glaucoma were classified in five groups based on visual field damage. Sensitivity and specificity of all glaucoma OCT parameters were analyzed. Receiver operating characteristic curves (ROC) and areas under the ROC ...

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    7. Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe

      Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe

      We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26.1 mm and a measured axial resolution of 8 μm (in air). In posterior segment mode, the design has a lateral resolution of 9 μm, 7.4 mm imaging depth ...

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    8. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial resolution of 1.78 μm was combined with an SRT system and time-resolved OCT M-scans of the target area were recorded from four patients undergoing SRT. Optical coherence tomography scans ...

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    9. Optical coherence tomography imaging apparatus, imaging system, and control apparatus and control method for controlling imaging range in depth direction of optical coherence tomography

      Optical coherence tomography imaging apparatus, imaging system, and control apparatus and control method for controlling imaging range in depth direction of optical coherence tomography

      An optical coherence tomography imaging apparatus that acquires a tomographic image from interference light between a reference beam and a measuring beam obtained via an object includes a control unit configured to control a difference in optical path length between the reference beam and the measuring beam by a control method according to an imaging target region, and a signal processing unit configured to generate image data of the object based on an electrical signal obtained by detecting the interference light with the difference in optical path length controlled by the control method.

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    10. Optical Coherence Tomography Reliable Monitor of MS Disease Progression

      Optical Coherence Tomography Reliable Monitor of MS Disease Progression

      Optical coherence tomography (OCT) may be useful in monitoring multiple sclerosis (MS) disease progression, and may be suitable as an investigative outcome in trials, research indicates. The study, published in Annals of Neurology, aimed to determine whether brain atrophy — as seen with OCT — was a valid indicator of neuronal tissue damage in multiple sclerosis. Shiv Saidha, MD, of Johns Hopkins University, and colleagues analyzed individual rates of change in retinal and brain structure measures using 3T MRI and cirrus high-definition OCT in 107 patients with MS.

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    11. The Ability of SD-OCT to Differentiate Early Glaucoma With High Myopia From Highly Myopic Controls and Nonhighly Myopic Controls

      The Ability of SD-OCT to Differentiate Early Glaucoma With High Myopia From Highly Myopic Controls and Nonhighly Myopic Controls

      Purpose : Optical coherence tomography (OCT) instruments do not embed a normative database from highly myopic normal (HMN) eyes. The abilities of three OCT instruments to detect early glaucoma with high myopia were compared using the two controls with or without high myopia. Methods : A total of 52 early glaucomatous eyes (mean deviation > −6.0 dB) with high myopia (spherical equivalent ≤ −6.0 diopters [HMG]), 54 HMN eyes, and 90 nonhighly myopic normal (NHMN) eyes were enrolled. Each participant was imaged using Cirrus, RTVue, and Topcon 3D OCT to evaluate the thicknesses of the circumpapillary retinal nerve fiber layer (cpRNFL), the ...

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    12. Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography

      Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography

      Purpose : To differentiate diabetic macular edema (DME) from pseudophakic cystoid macular edema (PCME) based solely on spectral-domain optical coherence tomography (SD-OCT). Methods : This cross-sectional study included 134 participants: 49 with PCME, 60 with DME, and 25 with diabetic retinopathy (DR) and ME after cataract surgery. First, two unmasked experts classified the 25 DR patients after cataract surgery as either DME, PCME, or mixed-pattern based on SD-OCT and color-fundus photography. Then all 134 patients were divided into two datasets and graded by two masked readers according to a standardized reading-protocol. Accuracy of the masked readers to differentiate the diseases based on ...

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    13. A neural network approach to retinal layer boundary identification from optical coherence tomography images

      A neural network approach to retinal layer boundary identification from optical coherence tomography images

      In this paper, we propose a method by which the boundaries of retinal layers in optical coherence tomography (OCT) images can be identified from a simple initial user input. The proposed method is a neural network approach in which the neural networks are trained to identify points within each layer, from which, the boundaries between the retinal layers are estimated. This method focuses on training neural networks to identify layers themselves, instead of boundaries, because the available date is richer and more cohesive as compared to boundary identification. Results are presented, demonstrating the effectiveness of this method.

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    14. Assessment of the Tear Meniscus Using Optical Coherence Tomography in Patients With Type 2 Diabetes Mellitus

      Assessment of the Tear Meniscus Using Optical Coherence Tomography in Patients With Type 2 Diabetes Mellitus

      Purpose: To analyze tear meniscus dimensions with Fourier domain-optical coherence tomography (FD-OCT) in patients with type 2 diabetes mellitus. Methods: Patients with type 2 diabetes without diabetic retinopathy (DR) (n = 54), with nonproliferative DR (n = 45), with proliferative DR (PDR) (n = 25), and controls (n = 45) were enrolled. Hemoglobin A1c and Early Treatment Diabetic Retinopathy Study (ETDRS) stages of DR were evaluated. Schirmer test (ST), tear breakup time test, and fluorescein corneal staining were carried out. Tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) were obtained by FD-OCT. Results: TMH, TMD, and TMA in the ...

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    15. Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization

      Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization

      Purpose . To assess the ability of optical coherence tomography-angiography (OCT-A) to show and analyze retinal vascular patterns and the choroidal neovascularization (CNV) in retinal vascular diseases. Methods . Seven eyes of seven consecutive patients with retinal vascular diseases were examined. Two healthy subjects served as controls. All eyes were scanned with the SD-OCT XR Avanti (Optovue Inc, Fremont CA, USA). Split spectrum amplitude decorrelation angiography algorithm was used to identify the blood flow within the tissue. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) with Spectralis HRA + OCT (Heidelberg Engineering GmbH) were performed. Results . In healthy subjects OCT-A visualized major macular ...

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    16. Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography

      Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography

      NaCl based solutions were applied as osmotic stress agents to alter the hydration state of the mouse eye. Full-eye responses to these osmotic challenges were monitored in vivo using a custom-built optical coherence tomography (OCT) with an extended imaging range of 12.38 mm. Dynamic changes in the mouse eye were quantified based on the OCT images using several parameters, including the central corneal thickness (CCT), the anterior chamber depth (ACD), the crystalline lens thickness (LT), the cornea-retina distance (CRD), the iris curvature (IC), and the lens scattering intensity (LSI). Apparent but reversible changes in the morphology of almost all ...

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    17. Depth evaluation of intended vs actual intacs intrastromal ring segments using optical coherence tomography

      Depth evaluation of intended vs actual intacs intrastromal ring segments using optical coherence tomography

      Purpose Evaluation of actual vs intended intrastromal corneal ring segments (ICRS) implantation depth as measured by anterior segment optical coherence tomography (OCT) Methods Prospective study evaluating 30 Intacs segments implanted manually in 19 eyes of 15 patients suffering from keratoconus. Segment depth evaluation was performed using anterior segment OCT. Measurements were performed above and below the segment at 3 points in relation to the incision site. Statistical analysis was performed using the SAS software for ANOVA, matched t-test, and GLIMMIX procedure. Results Intacs segment depth was 153-μm shallower than intended (58 % vs 80 % ). Segment layout demonstrated the proximal and ...

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    18. Retinal vessel structure measurement using spectral-domain optical coherence tomography

      Retinal vessel structure measurement using spectral-domain optical coherence tomography

      Purpose To assess the reliability and validity of spectral-domain optical coherence tomography (SD-OCT) measurements of retinal vessel lumen diameters and wall thicknesses. Methods SD-OCT was used to characterize the circular region around the optic disc of 40 eyes (20 subjects). The inner and outer sides (vitreal and choroidal sides) of the vessel wall and the luminal diameter were measured using intensity graphs. Results Mean arterial and venous luminal diameters were 95.1±16.1 and 132.6±17.8   μm, respectively. The wall thicknesses of inner and outer sides of the artery were 23.9±4.9 and 21.2 ...

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    19. Investigating the Choriocapillaris and Choroidal Vasculature with New Optical Coherence Tomography Technologies

      Investigating the Choriocapillaris and Choroidal Vasculature with New Optical Coherence Tomography Technologies

      The body of knowledge of in vivo investigation of the choroid has been markedly enhanced by recent technological advances in optical coherence tomography (OCT). New insights elucidating the morphological features of the choriocapillaris and choroidal vasculature, in both physiological and pathological conditions, indicate that the choroid plays a pivotal role in many posterior segment diseases. In this article, a review of the histological characteristics of the choroid, which must be considered for the proper interpretation of in vivo imaging, is followed by a comprehensive discussion of fundamental principles of the current state-of-the-art in OCT, including cross-sectional OCT, en face OCT ...

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    20. Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

      Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

      Objective: To evaluate the choroidal thickness in patients with multiple sclerosis (MS) using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: In this observational comparative study, 68 eyes of 34 MS patients and 60 eyes of 30 healthy subjects were evaluated. All participants underwent complete ophthalmologic examination and OCT scanning. Choroidal thickness measurements were performed at seven points. Results: The mean subfoveal choroidal thickness was reduced significantly in MS patients (310.71 ± 61.85 μm) versus healthy controls (364.85 ± 41.81 μm) (p < 0.001). The difference was also significant at all six measurement points (p < 0.001 for ...

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    21. Changes in Japanese eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study

      Changes in Japanese eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study

      Background To investigate the changes in anterior segment parameters, as assessed by anterior segment optical coherence tomography (ASOCT) in Japanese subjects after laser peripheral iridotomy (LPI). Design Prospective observational study Participants 72 subjects with angle closure including primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG). Methods Customized software was used to measure ASOCT parameters. Complete data of 51 subjects were available for final analysis. Main Outcome Measures Angle opening distance (AOD), trabecular-iris space area (TISA), anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV), iris thickness, curvature, and area, and lens ...

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    22. Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of Superficial and Deep Capillary Plexa

      Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of Superficial and Deep Capillary Plexa

      Purpose To evaluate the optical coherence tomography angiography(OCT-angiography) appearance of the superficial and deep capillary plexa in eyes with retinal vein occlusion (RVO) and to compare these findings with those of fluorescein angiography(FA) and spectral-domain optical coherence tomography(SD-OCT). Design : Retrospective observational case series. Method Patients presenting with RVO to Creteil University Eye Clinic were retrospectively evaluated. All patients had undergone a comprehensive ophthalmic examination including FA, SD-OCT and OCT-angiography. Results There were 54 (31 male, 57%) RVO patients with a mean age of 70 years. The perifoveal capillary arcade was visible in 52 eyes (96%) on OCT-angiography ...

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    23. Optical buffering methods, apparatus, and systems for increasing the repetition rate of tunable light sources

      Optical buffering methods, apparatus, and systems for increasing the repetition rate of tunable light sources

      In one embodiment, the invention relates to an apparatus for increasing the repetition rate in a light source. The apparatus includes a first optical coupler comprising a first arm, a second arm and a third arm; a first mirror in optical communication with the second arm of the first optical coupler; and a first optical delay line having a first end in optical communication with the third arm of the first optical coupler and a second end in optical communication with a second mirror, wherein light entering the first arm of the first optical coupler leaves the first arm of ...

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    24. Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy - Ophthalmology

      Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy - Ophthalmology

      Purpose To investigate ultrahigh-speed, swept-source optical coherence tomography (SSOCT) angiography for visualizing vascular changes in eyes with nonexudative age-related macular degeneration (AMD) with geographic atrophy (GA). Design Observational, prospective, cross-sectional study. Participants A total of 63 eyes from 32 normal subjects and 12 eyes from 7 patients with nonexudative AMD with GA. Methods A 1050-nm, 400-kHz A-scan rate SSOCT system was used to perform volumetric optical coherence tomography angiography (OCTA) of the retinal and choriocapillaris (CC) vasculatures in normal subjects and patients with nonexudative AMD with GA. Optical coherence tomography angiography using variable interscan time analysis (VISTA) was performed to ...

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