1. Articles in category: Ophthalmology

    577-600 of 6318 « 1 2 ... 22 23 24 25 26 27 28 ... 262 263 264 »
    1. Relationship between the Lamina Cribrosa, Outer Retina, and Choroidal Thickness as Assessed Using Spectral Domain Optical Coherence Tomography

      Relationship between the Lamina Cribrosa, Outer Retina, and Choroidal Thickness as Assessed Using Spectral Domain Optical Coherence Tomography

      Purpose To evaluate the characteristics and relationship between peripapillary choroidal thickness (pCT), lamina cribrosa thickness (LCT), and peripapillary outer retinal layer thickness (pORT) as determined using spectral domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI). Methods In total, 255 participants were included (87 healthy subjects, 87 glaucoma suspects (GS), and 81 glaucoma cases). The pORT, defined as the thickness between the posterior outer plexiform layer and the retinal pigment epithelium (RPE) interface, and the pCT, between the outer margin of the RPE and the choroidal-scleral interface, were manually measured using EDI scanning of the circumpapillary retinal nerve fiber layer ...

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    2. Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Purpose: To assess the reproducibility of iridocorneal angle (ICA) analysis in young, healthy Caucasian subjects using swept-source optical coherence tomography (SS-OCT) by determining variability and inter-observer agreement between expert and non-expert observers. Methods: Thirty-one healthy volunteers (non-experts) acquired 3 consecutive SS-OCT images of the right eyes of their peer non-experts. Images were analyzed by 31 non-experts and additionally by 3 experts, whereby the angle opening distance (AOD) and the trabecular iris space area (TISA) at 500µm and 750µm were calculated. A random intercept model was used to determine the amount of variation between observers. In addition, the intra-observer ...

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    3. Vitreopapillary Traction in Eyes with Idiopathic Epiretinal Membrane: A Spectral Domain Optical Coherence Tomography Study

      Vitreopapillary Traction in Eyes with Idiopathic Epiretinal Membrane: A Spectral Domain Optical Coherence Tomography Study

      Purpose To investigate the prevalence of vitreopapillary traction (VPT) and its effect on peripapillary structure and visual function in eyes with idiopathic epiretinal membrane (ERM). Design Observational, comparative study. Participants Patients with idiopathic ERM (n = 116 eyes) and controls with similar age (n = 62 eyes). Methods Spectral domain optical coherence tomography (SD-OCT) axial optic disc scans were evaluated to identify VPT in eyes with idiopathic ERM. Based on VPT presence/absence, eyes were categorized as ERM with VPT (ERM +VPT , n = 52 eyes) or ERM without VPT (ERM −VPT , n = 64 eyes). Optic nerve head (ONH) parameters, average and sectoral ...

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    4. Researchers Integrate Optical Coherence Tomography Device with Epidural Needle

      Researchers Integrate Optical Coherence Tomography Device with Epidural Needle

      The march of modern medicine is often driven by revolutions in medical imaging. When technology advances, doctors are better able to peer deeply into human tissues, and thus able to detect, diagnose and treat human diseases more effectively. Results of OCT-guided insertion are shown. A)The porcine spine used for experiment. B) Anatomy of lumbar spine (sagittal view). C) Images acquired by GRIN needle device corresponding to different tissues. Credit: Qinggong Tang Now, researchers have taken an established imaging technology called "optical coherence tomography," or OCT, and integrated it with other instruments to bring about the next revolution in imaging ...

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    5. Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT

      Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT

      Purpose . To assess the macular, choroid, and peripapillary nerve fiber layer thickness (RNFL) in Behçet’s disease (BD) patients with and without ocular involvement by means of optical coherence tomography (OCT) and compare these findings with healthy controls. Design . Eighty patients with BD and 40 healthy controls who were followed up at the Uveitis and Retina Clinic of the Kayseri Research and Education Hospital in Turkey were enrolled in this prospective study. Subjects and Controls . The patients with BD were divided into two groups according to the presence of ocular involvement. Group 1 consisted of 40 eyes of 40 ...

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    6. Calculating the predicted retinal thickness from spectral domain and time domain optical coherence tomography – comparison of different methods

      Calculating the predicted retinal thickness from spectral domain and time domain optical coherence tomography – comparison of different methods

      Purpose To compare the accuracy of different methods of calculating predicted central retinal thickness values in order to allow comparison between results of spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) devices. Methods In a prospective cohort study, 100 consecutive healthy individuals without ocular disease underwent sequential scanning with SD-OCT (Spectralis OCT) and TD-OCT (Stratus OCT). A group of 60 eyes was used to generate the conversion equations, which were tested on the remaining 140 eyes. Four equations were used: 1. Mean difference between SD-OCT and TD-OCT; 2. Multiplying a ratio by the original retinal thickness; 3. Linear regression ...

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    7. Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Recently, many authors have propagated the notion that a specific form of “microcystic macular edema” occurs in patients with optic neuritis and optic atrophy of various etiology and is due to retrograde synaptic degeneration. The finding is isolated to the inner nuclear layer on spectral-domain optical coherence tomography in most cases, and is present in a parafoveal, circumferential, and central macular distribution. This perspective critically reviews the evidence and suggests that inner nuclear layer cystoid changes are an early and nonspecific indicator of typical cystoid macular edema of any cause, and that the finding is likely not a distinct entity.

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    8. MORPHOLOGIC FEATURES AND EVOLUTION OF INNER RETINAL DIMPLES ON OPTICAL COHERENCE TOMOGRAPHY AFTER INTERNAL LIMITING MEMBRANE PEELING

      MORPHOLOGIC FEATURES AND EVOLUTION OF INNER RETINAL DIMPLES ON OPTICAL COHERENCE TOMOGRAPHY AFTER INTERNAL LIMITING MEMBRANE PEELING

      Purpose: To evaluate morphologic features and the evolution of inner retinal dimples using spectral domain optical coherence tomography after internal limiting membrane peeling. Methods: A single-center retrospective study of spectral domain optical coherence tomography features in 43 eyes after full-thickness macular hole surgery with internal limiting membrane peeling without adjunctive internal limiting membrane staining. Results: Postoperatively, a total of 210 dimples were noted in 37 eyes (86%), with a mean of 5.7 dimples per eye (median, 5; range, 1-20), most frequently located in the inferotemporal quadrant (n = 122, 58%, P < 0.0001). At initial detection, mean dimple dimensions were ...

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      Mentions: UCLA
    9. Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging

      Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging

      Purpose: The purpose of this study was to compare images of the retina and choroid obtained with Spectralis 1050-nm spectral-domain optical coherence tomography (SD-OCT) with and without enhanced depth imaging (EDI) to the commercially available 870-nm SD-OCT with and without EDI. Methods: Full-length 30° line scans were obtained with both 870- and 1050-nm Spectralis OCT instruments, with and without EDI. Two trained retina physicians masked to wavelength and EDI status assessed the ability to visualize the vitreoretinal interface and full-thickness choroid, and subfoveal choroidal thickness (SFCT) was measured. Results: Included in the study were 21 eyes. The vitreoretinal interface was ...

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    10. Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography for Monitoring Anti-VEGF Therapy in Myopic Choroidal Neovascularization

      Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography for Monitoring Anti-VEGF Therapy in Myopic Choroidal Neovascularization

      Iacono P.

      Battaglia Parodi M.

      Papayannis A.

      Kontadakis S.

      Da Pozzo S.

      Cascavilla M.L.

      La Spina C.

      Varano M.

      Bandello F.

      Aim: To evaluate the agreement between fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) in detecting myopic choroidal neovascularization (CNV) activity during bevacizumab treatment. Methods: Thirty-four patients with subfoveal myopic CNV were prospectively enrolled. FA and SD-OCT were performed at baseline and at all planned monthly visits.

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    11. Methods and devices for measuring tear film and diagnosing tear disorders

      Methods and devices for measuring tear film and diagnosing tear disorders

      Methods and devices measure eye blinks and tear film lipid and aqueous layer thickness before and following ophthalmic formula application onto the ocular surface, especially wherein the ophthalmic formula is an artificial tear. The methods and devices are suitable for dry eye diagnosis. The methods and devices are suitable for use to evaluate ophthalmic formula effects on the tear film and to use such information to diagnose ophthalmic formula treatment of ocular disease conditions such as dry eye in the absence of contact lens wear or post-surgical eye drop treatment and diagnosis. The methods and devices are also suitable for ...

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    12. Ophthalmologic apparatus and blood flow velocity calculation method

      Ophthalmologic apparatus and blood flow velocity calculation method

      An ophthalmologic apparatus includes an irradiation unit irradiating a subject's eye with a measuring beam emitted by a scanning unit that performs scanning, a first acquisition unit acquiring a first image of the subject's eye based on the returned measuring beam from the subject's eye when the scanning unit performs scanning in a first sub scanning direction, a second acquisition unit acquiring a second image of the subject's eye based on the returned measuring beam travelling from the subject's eye, at timing different from that for the first image, while the scanning unit performs scanning ...

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    13. Instrument for examining or machining a human eye

      Instrument for examining or machining a human eye

      An instrument is proposed for examining or machining a human eye, with an eye-tracker for acquiring eye movements and for outputting a signal that is representative of the acquired eye movements, the eye-tracker including an interferometric image-acquisition device that has been set up for time-resolved acquisition of sectional images of the eye and that operates on the basis of two-dimensional or three-dimensional optical coherence tomography, and also an evaluating module ascertaining the eye movements solely from the sectional images.

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    14. Optical deflection device for scanning, ophthalmologic measurement and therapy system

      Optical deflection device for scanning, ophthalmologic measurement and therapy system

      An optical deflection unit for targeted radiation, e.g., produced by laser or superluminescent diodes, in scanning, ophthalmological measuring and therapy systems, comprises a deflection mirror, a position sensor and a control unit, which form a control circuit for minimizing the deviation of the actual positions, detected by the position sensor, from the desired positions of the deflection mirror, whereby the optical deflection unit comprises a deflection mirror, oscillatingly movable by means of non-contacting electromagnetic drives around at least one rotation axis, and which is positioned in the direction of the, at least, one rotation axis between at least two ...

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    15. Evaluating the Short-Term Results of KAMRA Inlay Implantation Using Real-Time Optical Coherence Tomography-Guided Femtosecond Laser Technology

      Evaluating the Short-Term Results of KAMRA Inlay Implantation Using Real-Time Optical Coherence Tomography-Guided Femtosecond Laser Technology

      PURPOSE: To evaluate the outcomes from using real-time optical coherence tomography (OCT)-guided femtosecond laser technology for pocket creation for KAMRA inlay (Acufocus, Inc., Irvine, CA) implantation surgery. METHODS: One hundred fifty-one eyes underwent KAMRA inlay implantation using the real-time OCT-guided femtosecond laser for pocket creation. All patients had a history of prior LASIK. Uncorrected distance visual acuity, corrected distance visual acuity, uncorrected near visual acuity, corrected near visual acuity, and manifest refraction spherical equivalent were evaluated preoperatively and postoperatively. The follow-up period was 3 months. RESULTS: Mean manifest refraction spherical equivalent, uncorrected distance visual acuity, and uncorrected near visual ...

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    16. Automated retinal layer segmentation and characterization

      Automated retinal layer segmentation and characterization

      Spectral Domain Optical Coherence Tomography (SD-OCT) is a valuable diagnostic tool in both clinical and research settings. The depth-resolved intensity profiles generated by light backscattered from discrete layers of the retina provide a non-invasive method of investigating progressive diseases and injury within the eye. This study demonstrates the application of steerable convolution filters capable of automatically separating gradient orientations to identify edges and delineate tissue boundaries. The edge maps were recombined to measure thickness of individual retinal layers. This technique was successfully applied to longitudinally monitor changes in retinal morphology in a mouse model of laser-induced choroidal neovascularization (CNV) and ...

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    17. Analysis of the Time and Location of the Silicone Oil Emulsification by Spectral-Domain Optical Coherence Tomography after Silicone Oil Tamponade

      Analysis of the Time and Location of the Silicone Oil Emulsification by Spectral-Domain Optical Coherence Tomography after Silicone Oil Tamponade

      Purpose . To estimate localization and the period up to the appearance of small hyperreflective round-shaped droplets using spectral-domain optical coherence tomography (SD-OCT) after pars plana vitrectomy with silicone oil tamponade. Methods . A retrospective observational study included 24 patients who had undergone pars plana vitrectomy with silicone oil tamponade for proliferative vitreoretinopathy (PVR) retinal detachment. SD-OCT analysis was performed 1, 3, and 6 months after surgery. We characterized the emulsified silicone oil in the SD-OCT as the small hyperreflective round-shaped droplets. Results . In SD-OCT examination, none of the patients had hyperreflective round-shaped droplets visible one month after vitrectomy with silicone oil ...

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    18. Radial versus raster spectral-domain optical coherence tomography scan patterns for detection of macular pathology

      Radial versus raster spectral-domain optical coherence tomography scan patterns for detection of macular pathology

      Purpose To compare the 6-line radial versus the 25-line raster spectral-domain optical coherence tomography (SD-OCT) acquisition patterns at detecting intraretinal fluid, subretinal fluid, vitreomacular traction, and full-thickness macular hole (MH). Design Retrospective cross-sectional analysis. Methods Series of 365 eyes with neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), central and branch retinal vein occlusion (CRVO/BRVO), central serous chorioretinopathy, vitreomacular traction, and full-thickness MH. Sequential 6-line radial and 25-line raster scans were evaluated for intraretinal/subretinal fluid and when applicable, vitreomacular traction and MH. Results For neovascular AMD (133 scans), seven 25-line raster scans confirmed subretinal/intraretinal fluid not ...

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    19. PREVALENCE AND SPATIAL DISTRIBUTION OF CYSTOID SPACES IN RETINITIS PIGMENTOSA: Investigation With Spectral Domain Optical Coherence Tomography

      PREVALENCE AND SPATIAL DISTRIBUTION OF CYSTOID SPACES IN RETINITIS PIGMENTOSA: Investigation With Spectral Domain Optical Coherence Tomography

      Purpose: To investigate the prevalence and spatial distribution of cystoid spaces (CS) in retinitis pigmentosa patients with spectral domain optical coherence tomography. Methods: A total of 529 eyes of 275 patients with retinitis pigmentosa were examined with spectral domain optical coherence tomography. The presence or absence of CS was judged for each eye. Retinal layer and outer retinal status where the CS existed were also investigated. Statistical analysis was performed using 1 eye per 1 patient. Results: Cystoid spaces were present in 119 of 529 eyes (22.5%) of 74 of 275 patients (26.9%). There were no significant differences ...

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    20. Central and midperipheral corneal thickness measured with scheimpflug imaging and optical coherence tomography

      Central and midperipheral corneal thickness measured with scheimpflug imaging and optical coherence tomography

      Purpose To compare corneal thickness measurements using Pentacam (Oculus, Germany), Sirius (CSO, Italy), Galilei (Ziemer, Switzerland), and RTVue-100 OCT (Optovue Inc., USA). Methods Sixty-six eyes of 66 healthy volunteers were enrolled. Three consecutive measurements were performed with each device. The mean value of the three measurements was used for subsequent analysis. Central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT; measured at superior, inferior, nasal, and temporal locations with a distance of 1 mm (CT 2mm ) or 2.5 mm (CT 5mm ) from the corneal apex) were analyzed. Differences and agreement between measurements were assessed using ...

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    21. Artifacts in optical coherence tomography

      Artifacts in optical coherence tomography

      Optical coherence tomography (OCT) is now an integral part of management for numerous retinal diseases for diagnosis, treatment planning and follow up. OCT interpretation must involve the understanding of the associated artifacts. These artifacts can mislead physicians to wrong diagnosis or inappropriate management. This review article discusses the various types of artifacts in OCT scans obtained from various devices in various retinal diseases. This article would help to improve the understanding about the various artifacts and their clinical importance.

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    22. Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

      Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

      We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.

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    23. Volcano like pattern in optical coherence tomography in chronic diabetic macular edema

      Volcano like pattern in optical coherence tomography in chronic diabetic macular edema

      In this article we herein report an interesting vitreo-macular interface abnormality associated with chronic diabetic cystoid macular edema. It is an observational case study of three diabetic patients examined in the diabetic clinic. All the patients had proliferative diabetic retinopathy with chronic macular edema. A serial cross sectional OCT examination and tracking of both the longitudinal progression of macular thickening and vitreo-macular interface revealed cystoid macular edema with a characteristic hyperreflective vitreous shadow emerging from the vitreofoveal interface. All the patients had dehiscence of inner retinal layers. This particular morphological feature at the vitreo-foveolar interface, which we name as “volcano ...

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    24. Scanning laser ‘en face’ retinal imaging of epiretinal membranes

      Scanning laser ‘en face’ retinal imaging of epiretinal membranes

      Purpose Comparison of scanning laser ophthalmoscopy (SLO) based ‘en face’ imaging techniques of patients with epiretinal membranes (ERM) and evaluation of the accuracy of preoperative diagnostic imaging. Methods A consecutive, prospective series of 53 study eyes of 46 patients with clinically diagnosed and in optical coherence tomography (OCT) confirmed symptomatic ERMs were included in this study. Spectral domain (SD-) OCT volume scans (20° × 20° with 49 horizontal sections, ART 15) including SLO en face and fundus autofluorescence (FAF) images of the macula were obtained with HRA2 (Heidelberg Retina Angiograph-Optical Coherence Tomography, Heidelberg Engineering, Heidelberg, Germany). In addition, wide-field SLO color ...

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