1. Articles in category: Ophthalmology

    577-600 of 8971 « 1 2 ... 22 23 24 25 26 27 28 ... 372 373 374 »
    1. QUALITATIVE AND QUANTITATIVE FOLLOW-UP USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VEIN OCCLUSION TREATED WITH ANTI-VEGF: Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      QUALITATIVE AND QUANTITATIVE FOLLOW-UP USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VEIN OCCLUSION TREATED WITH ANTI-VEGF: Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      Purpose: To evaluate changes of vascular flow of patients treated with intravitreal injections of anti-vascular endothelial growth factor for macular edema secondary to retinal vein occlusion (RVO) with optical coherence tomography angiography (OCTA). Methods: Patients with RVO with macular edema and treated with intravitreal injections of anti-vascular endothelial growth factors were retrospectively evaluated. The following examinations were performed before and after treatment: best-corrected visual acuity, spectral domain optical coherence tomography, fluorescein angiography, and OCTA (Optovue, Inc). Automatic measurement of vascular density of the superficial and deep capillary plexus was also performed and compared with age- and sex-matched healthy subjects. Results ...

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    2. Primary posterior capsulotomy in femtosecond laser–assisted cataract surgery: In vivo spectral-domain optical coherence tomography study

      Primary posterior capsulotomy in femtosecond laser–assisted cataract surgery: In vivo spectral-domain optical coherence tomography study

      Purpose To evaluate whether the size of Berger space is safely predictable in patients having cataract surgery using 3-dimensional spectral-domain optical coherence tomographic (3-D SD-OCT) image analysis. Setting Ruhr University Eye Hospital, Bochum, Germany. Design Prospective interventional case series. Methods Eyes having routine femtosecond laser–assisted cataract surgery were included. After wound closure, the anterior eye segment was visualized using the incorporated 3-D SD-OCT. Visualization of Berger space was performed in the axial and sagittal planes. Results The study comprised 165 consecutive eyes. In 155 eyes, 3-D SD-OCT visualized Berger space and its dimensions were analyzed. In 72% of the ...

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    3. TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

      TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

      Purpose: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. Methods: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds ...

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    4. Optical coherence tomography angiography: an overview of the technology and an assessment of applications for clinical research

      Optical coherence tomography angiography: an overview of the technology and an assessment of applications for clinical research

      In recent years, ophthalmology has experienced significant developments with respect to imaging modalities. Optical coherence tomography angiography is one such technology that seeks to improve diagnostics for retinal diseases. Using standard structural ocular coherence tomography hardware, optical coherence tomography angiography demonstrates the ability to non-invasively visualise the vasculature in the retina and the choroid with high resolution, allowing greater insight into retinal vascular pathologies. In addition, retinal and choroidal vessel density and blood flow can be quantified, offering potential to assist in the diagnosis of a variety of retinal diseases. To date, numerous retinal diseases, such as open-angle glaucoma, have ...

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    5. New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives a 2016 NIH Grant for $714,891 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2016 and ends in 2019. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of upmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project ...

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    6. Celloptic Incorporated Receives NIH Grant for A New Holographic 3D Camera for Fundus Imaging

      Celloptic Incorporated Receives NIH Grant for A New Holographic 3D Camera for Fundus Imaging

      Celloptic Incorporated Receives a 2016 NIH Grant for $225,635 for A New Holographic 3D Camera for Fundus Imaging. The principal investigator is Gary Brooker. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. A NEW HOLOGRAPHIC 3D CAMERA FOR FUNDUS IMAGING Abstract In the United States, retinal disease is the most common cause of visual impairment, with age-related macular degeneration (AMD) and diabetic retinopathy (DR) being the most common retinal diseases. For each of the above conditions, high resolution and three-dimensional (3D) imaging of the retina, retinal vasculature, choroid and/or ...

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    7. Assessment of Anterior Segment Measurements with Swept Source Optical Coherence Tomography before and after Ab Interno Trabeculotomy (Trabectome) Surgery

      Assessment of Anterior Segment Measurements with Swept Source Optical Coherence Tomography before and after Ab Interno Trabeculotomy (Trabectome) Surgery

      Purpose . To compare the changes of anterior segment parameters, assessed by swept source anterior segment optical coherence tomography (AS-OCT) after combined Trabectome-cataract surgery and Trabectome-only surgery in open angle glaucoma patients. Methods . Thirty-eight eyes of 24 patients with open angle glaucoma were scanned with swept source AS-OCT before and 4 weeks after combined Trabectome-cataract or Trabectome-only surgery. Intraocular pressure, number of medications, and AS-OCT parameters, such as angle opening distance at 500 and 750  μ m from the scleral spur (AOD500 and AOD750), trabecular-iris space area at 500 and 750 mm 2 (TISA500, TISA750), angle recess area at 500 and 750 ...

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      Mentions: Vikas Chopra
    8. Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation

      Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation

      Purpose: Spectral domain optical coherence tomography (SD-OCT) imaging permits in vivo visualization of the choroid with micron-level resolution over wide areas and is of interest for studies of ocular growth and myopia control. We evaluated the speed, repeatability, and accuracy of a new image segmentation method to quantify choroid thickness compared to manual segmentation. Methods: Two macular volumetric scans (25 x 30[degrees]) were taken from 30 eyes of 30 young adult subjects in two sessions, 1 hour apart. A single rater manually delineated choroid thickness as the distance between Bruch's membrane and sclera across three B-scans (foveal, inferior ...

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    9. HYPERREFLECTIVE RETINAL SPOTS IN NORMAL AND DIABETIC EYES: B-Scan and En Face Spectral Domain Optical Coherence Tomography Evaluation

      HYPERREFLECTIVE RETINAL SPOTS IN NORMAL AND DIABETIC EYES: B-Scan and En Face Spectral Domain Optical Coherence Tomography Evaluation

      Purpose: To evaluate hyperreflective retinal spots (HRS), in normal subjects and diabetic patients without and with macular edema (diabetic macular edema, DME), on linear B-scans and corresponding en face image of spectral-domain optical coherence tomography. Methods: Retrospective evaluation of images of 54 eyes/subjects (16 normal subjects, 19 diabetic patients without DME, and 19 with DME). On horizontal B-scan spectral-domain optical coherence tomography, passing through the center of the fovea, the following characteristics of HRS were evaluated: location (inner retina or outer retina), size (<=30 or >30 [mu]m), reflectivity (similar to nerve fiber layer or to retinal pigment epithelium-Bruch ...

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    10. FOVEAL HYPOPLASIA: DIAGNOSIS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      FOVEAL HYPOPLASIA: DIAGNOSIS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To describe the clinical presentations and image findings of a patient with foveal hypoplasia. Methods: Observational case report of one patient. The clinical presentation of the patient was documented by fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography. Results: A 55-year-old healthy white female with bilateral foveal hypoplasia without nystagmus was presented. There were no signs suggestive of ocular albinism. Absence of foveal depression was noted on both clinical examination and optical coherence tomography. Lack of foveal avascular zone was confirmed on fluorescein angiography and optical coherence tomography angiography. Conclusion: To the best of our knowledge this ...

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    11. Clinical Usefulness of Spectral-Domain Optical Coherence Tomography in Glaucoma and NAION

      Clinical Usefulness of Spectral-Domain Optical Coherence Tomography in Glaucoma and NAION

      The development of optical coherence tomography (OCT) has changed the clinical management of ophthalmic diseases by furthering the understanding of pathogenesis, as well as improving the monitoring of their progression and assisting in quantifying the response to treatment modalities in ophthalmic diseases. Initially, the two-dimensional configuration of the optic nerve head (ONH) and the thickness of the retinal nerve fiber layer (RNFL) were the main OCT structural parameters used in clinical management of optic nerve diseases. Now, with higher resolution power and faster acquisition times, the details of ONH and the retina including the macular area can be measured using ...

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    12. Intraoperative Interface Fluid Dynamics and Clinical Outcomes for Intraoperative OCT-Assisted DSAEK from the Pioneer Study

      Intraoperative Interface Fluid Dynamics and Clinical Outcomes for Intraoperative OCT-Assisted DSAEK from the Pioneer Study

      Purpose To correlate intraoperative interface fluid dynamics during Descemet stripping automated endothelial keratoplasty (DSAEK) surgery using intraoperative optical coherence tomography (iOCT) in the PIONEER (Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CohEncE TomogRaphy) study with postoperative outcomes. Design Prospective consecutive, interventional, comparative case series Participants One hundred and seventy-eight eyes of 173 patients undergoing DSAEK from the Cole Eye Institute, Cleveland, USA. Methods Eyes that underwent DSAEK between October 2011 and March 2014 from the PIONEER intraoperative and perioperative OCT study were included. An automated interface fluid segmentation algorithm evaluated intraoperative dynamics of interface fluid before and after surgical ...

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    13. Macular disease detection with a swept-source optical coherence tomography-based biometry device in patients scheduled for cataract surgery

      Macular disease detection with a swept-source optical coherence tomography-based biometry device in patients scheduled for cataract surgery

      Purpose To assess the sensitivity and specificity for detecting macular disease with a new optical biometry device with swept-source optical coherence tomography (SS-OCT) used before cataract surgery. Setting Hanusch Hospital, Vienna, Austria. Design Consecutive case series. Methods This study included patients with or without macular disease. All patients were scanned using the new biometry device (IOLMaster 700), which allows a 1.0 mm central retinal scan using SS-OCT technology. Also, all eyes were assessed using a dedicated retinal OCT device (RTVue) on the same day. Two experienced examiners and 1 ophthalmology resident graded all scans individually. Sensitivity and specificity for ...

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    14. Optical coherence tomography for the preoperative assessment of cataract surgery

      Optical coherence tomography for the preoperative assessment of cataract surgery

      We read with interest the article by Klein et al.1 describing the preoperative use of spectral-domain optical coherence tomography (SD-OCT) to detect subclinical macular disease before implantation of advanced-technology intraocular lenses (IOLs) such as multifocal or toric models. We fully agree with the authors that SD-OCT has an important role to play in the preoperative measures used to identify patients with occult macular disease that might affect visual outcomes after cataract surgery.

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    15. Atlas-based shape analysis and classification of retinal optical coherence tomography images using the functional shape (fshape) framework

      Atlas-based shape analysis and classification of retinal optical coherence tomography images using the functional shape (fshape) framework

      We propose a novel approach for quantitative shape variability analysis in retinal optical coherence tomography images using the functional shape (fshape) framework. The fshape framework uses surface geometry together with functional measures, such as retinal layer thickness defined on the layer surface, for registration across anatomical shapes. This is used to generate a population mean template of the geometry-function measures from each individual. Shape variability across multiple retinas can be measured by the geometrical deformation and functional residual between the template and each of the observations. To demonstrate the clinical relevance and application of the framework, we generated atlases of ...

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    16. Swept Source Optical Coherence Tomography Angiography for Contact Lens-Related Corneal Vascularization

      Swept Source Optical Coherence Tomography Angiography for Contact Lens-Related Corneal Vascularization

      Purpose . To describe a novel technique of adapting a swept-source optical coherence tomography angiography (OCTA) to image corneal vascularization. Methods . In this pilot cross-sectional study, we obtained 3 × 3 mm scans, where 100,000 A-scans are acquired per second with optical axial resolution of 8  μ m and lateral resolution of 20  μ m. This was performed with manual “XYZ” focus without the anterior segment lens, until the focus of the corneoscleral surface was clearly seen and the vessels of interest were in focus on the corresponding red-free image. En face scans were evaluated based on image quality score and repeatability. Results ...

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    17. Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy

      Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy

      This study aimed to assess the relationship between the rate of nerve fiber loss in non-arteritic anterior ischemic optic neuropathy (NAION) and time delay before therapy. Total 24 patients received the same treatment within or after 2wk (early and late groups). There were significantly lower level of destruction of nerve fibers (P=0.0014) and significantly better visual field sensitivity (P=0.039) in early group. The results indicate that therapy should be started within 2wk. The degree of ischemic damage due to NAION correlates well with retinal nerve fiber layer thickness and the ischemia-induced decrease in visual field sensitivity.

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      Mentions: András Berta
    18. OCT upgrade may help improve glaucoma detection

      OCT upgrade may help improve glaucoma detection

      Heidelberg Engineering says the FDA approved its new upgrade for the Spectralis OCT platform , the Glaucoma Module Premium Edition, which allows better diagnostic accuracy through objective measurement parameters. Driven by a proprietary new technology called the Anatomic Positioning system, the module creates detailed maps of each patient’s eyes using the center of the fovea and the center of Bruch’s membrane opening as orienting landmarks. All subsequent scans are automatically aligned to the unique map, allowing for comprehensive and highly precise monitoring of the optic nerve head, retinal nerve fiber layer, and ganglion cell layer over time. The tool ...

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    19. Characteristics and variations of in vivo Schlemm's canal and collector channel microstructures in enhanced-depth imaging optical coherence tomography

      Characteristics and variations of in vivo Schlemm's canal and collector channel microstructures in enhanced-depth imaging optical coherence tomography

      Background/aims To characterise in vivo Schlemm's canal (SC) and collector channels (CC) microstructures using enhanced-depth imaging (EDI) optical coherence tomography (OCT). Methods Serial horizontal EDI OCT B-scans (81 scans, 15×5° rectangle) were prospectively obtained in the nasal and temporal limbus. SC cross-sectional area (CSA) was measured by delineating its lumen in each B-scan. CCs connected to SC were counted. SC CSA and the number of CCs were compared between the nasal and temporal areas. Results Eleven eyes (11 normal subjects) were included (mean age, 28±5 years). SC and CCs were clearly demarcated in EDI OCT B-scans ...

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    20. Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris

      Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris

      Despite the prevalence of optical imaging techniques to measure hemodynamics in large retinal vessels, quantitative measurements of retinal capillary and choroidal hemodynamics have traditionally been challenging. Here, a new imaging technique called dynamic contrast optical coherence tomography (DyC-OCT) is applied in the rat eye to study microvascular blood flow in individual retinal and choroidal layers in vivo. DyC-OCT is based on imaging the transit of an intravascular tracer dynamically as it passes through the field-of-view. Hemodynamic parameters can be determined through quantitative analysis of tracer kinetics. In addition to enabling depth-resolved transit time, volume, and flow measurements, the injected tracer ...

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    21. Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography

      Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography

      Purpose : To evaluate the diagnostic ability of layer-by-layer segmented macular ganglion cell complex (GCC) using spectral-domain optical coherence tomography (OCT) for detection of glaucoma and to analyze the topographic patterns of the segmented thicknesses in open-angle glaucoma. Methods : Seventy-seven open-angle glaucoma patients and 59 healthy subjects were enrolled in this cross-sectional study. Spectral-domain OCT with automated segmentation was used to measure the separate thicknesses of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL). We compared the specific diagnostic abilities of the GCC (RNFL+GCL+IPL), ganglion cell–inner plexiform layer (GCIPL: GCL+IPL ...

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    22. Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia

      Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia

      Purpose : To compare the diagnostic powers of parameters of the RTVue and Cirrus-HD optical coherence tomography (OCT) systems in detecting glaucoma in highly myopic eyes. Methods : For this study, 28 glaucoma patients with high myopia (HM-G) and 28 high-myopia controls (HM-C) were enrolled. The circumpapillary retinal nerve fiber layer (cp-RNFL) and ganglion cell complex (GCC) parameters in the RTVue-OCT, and the ganglion cell–inner plexiform layer (GCIPL) and cp-RNFL parameters in the Cirrus HD-OCT, were obtained for each subject. The receiver operating characteristics curve (ROC) was used to assess the diagnostic ability of each parameter, and the areas under the ...

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    23. Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases

      Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases

      Optical coherence tomography (OCT) is a noncontact technology that produces high-resolution cross-sectional images of ocular tissues. Anterior segment OCT (AS-OCT) enables the precise visualization of anterior segment structure; thus, it can be used in various corneal and ocular surface disorders. In this review, the authors will discuss the application of AS-OCT for diagnosis and management of various corneal and ocular surface disorders. Use of AS-OCT for anterior segment surgery and postoperative management will also be discussed. In addition, application of the device for research using human data and animal models will be introduced.

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