1. Articles in category: Ophthalmology

    577-600 of 6246 « 1 2 ... 22 23 24 25 26 27 28 ... 259 260 261 »
    1. Short coherence interferometer

      Short coherence interferometer

      A short coherence interferometer apparatus for measuring multiple axially spaced regions of a specimen, in particular the eye, which has at least one measuring beam path, through which multiple individual measuring beams are incident on the specimen, and one reference beam path, through which a reference beam runs, with which the individual measuring beams are superimposed and brought into interference. The individual measuring beams are axially offset to one another upon incidence on the specimen by an amount which is adapted to the axial spacing. The interferometer apparatus superimposes each individual measuring beam with the reference beam in an interfering ...

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    2. Apparatus and method for imaging an eye

      Apparatus and method for imaging an eye

      The present invention is a slit lamp mounted eye imaging, a slit lamp integrated, a handheld, OCT integrated, or attached to a separate chinrest-joystick assembly apparatus and method for producing a wide field and/or magnified views of the posterior or the anterior segments of an eye through an undilated or dilated pupil. The apparatus images sections and focal planes and utilizes an illumination system that uses one or more LEDs, shifting optical elements, flipping masks, and/or aperture stops where the light can be delivered into the optical system on optical axis or off axis from center of optical ...

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    3. A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography

      A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography

      Purpose To evaluate a simplified method to measure choroidal thickness (CT) using commercially available enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods We measured CT in 31 subjects without ocular diseases using Spectralis EDI SD-OCT. The choroid-scleral interface of the acquired images was first enhanced using a post-processing compensation algorithm. The enhanced images were then analysed using Photoshop. Two graders independently graded the images to assess inter-grader reliability. One grader re-graded the images after 2 weeks to determine intra-grader reliability. Statistical analysis was performed using intra-class correlation coefficient (ICC) and Bland-Altman plot analyses. Results Using adaptive compensation ...

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    4. Johns Hopkins University Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosis

      Johns Hopkins University Receives  NIH Grant for Imaging Neurodegeneration in Multiple Sclerosis

      Johns Hopkins University Receives a 2014 NIH Grant for $436,412 for Imaging Neurodegeneration in Multiple Sclerosis. The principle investigator is Peter Calabresi. The program begain in 2013 and ends in 2018. Below is a summary of the proposed work. There is emerging evidence that gray matter (GM) degeneration is common in multiple sclerosis (MS), and more closely linked with disability than white matter (WM) injury. Indeed, WM volumes, as measured by high resolution MRI, wax and wane as a reflection of inflammation, whereas GM atrophy accelerates with time in MS. Whether GM degeneration purely results from WM injury or ...

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    5. Bioptigen Receives NIH Grant for Pediatric Spectral Domain Optical Coherence Tomography

      Bioptigen Receives NIH Grant for Pediatric Spectral Domain Optical Coherence Tomography

      Bioptigen Receives 2014 NIH grant for $99,516 for Pediatric Spectral Domain Optical Coherence Tomography. The principle investigator is Eric Buckland. The program began in 2008 and ends in 2015. Below is a summary of the proposed work. Acquiring diagnostic images of the retina in children is necessary to the prevention and treatment of pediatric eye disease, but it is often difficult due to the large range of eye shapes and sizes from preemies to older children and the inability of most children within this range to fixate. Fundus photography only provides a two- dimensional surface picture of the retina ...

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    6. Modern technologies for retinal scanning and imaging: an introduction for the biomedical engineer

      Modern technologies for retinal scanning and imaging: an introduction for the biomedical engineer

      This review article is meant to help biomedical engineers and nonphysical scientists better understand the principles of, and the main trends in modern scanning and imaging modalities used in ophthalmology. It is intended to ease the communication between physicists, medical doctors and engineers, and hopefully encourage "classical" biomedical engineers to generate new ideas and to initiate projects in an area which has traditionally been dominated by optical physics. Most of the methods involved are applicable to other areas of biomedical optics and optoelectronics, such as microscopic imaging, spectroscopy, spectral imaging, opto-acoustic tomography, fluorescence imaging etc., all of which are with ...

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    7. Sequential Spectral Domain Optical Coherence Tomography Imaging of An Eye After Successful Removal of Subfoveal Perfluorcarbon Liquid Collection

      Sequential Spectral Domain Optical Coherence Tomography Imaging of An Eye After Successful Removal of Subfoveal Perfluorcarbon Liquid Collection

      Purpose: To evaluate retinal restoration after subfoveal perfluorcarbon liquid (PFCL) bubble removal by means of autofluorescence, infrared, and spectral domain optical coherence tomography over 2 years of follow-up. Methods: A 62-year-old patient underwent two 23-gauge vitrectomies in attempt to remove subretinal PFCL retained under the fovea secondary to retinal detachment surgery in the left eye. We assessed best-corrected visual acuity, fundus biomicroscopy, retinal imaging by autofluorescence, infrared, and spectral domain optical coherence tomography at the first observation of retained PFCL, 1 day after the first attempt of PFCL removal, and 1, 30, 90, and 180 days, and 2 years after ...

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    8. Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Purpose: To analyze the influence of ocular magnification on the peripapillary retinal nerve fiber layer (RNFL) thickness measurement and its performance as acquired with spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT measurements from 108 normal eyes (59 subjects) and 72 glaucoma eyes (58 patients) were exported and custom software was used to correct RNFL measurements for ocular magnification. RNFL prediction limits in normal subjects, structure-function relationships, and RNFL performance for detection of glaucoma were compared before and after correction for ocular magnification (Bennett's formula). Association of disc area with cross-sectional RNFL area was explored. Results: The median (interquartile range ...

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    9. Sectoral variations of iridocorneal angle width and iris volume in Chinese Singaporeans: a swept-source optical coherence tomography study

      Sectoral variations of iridocorneal angle width and iris volume in Chinese Singaporeans: a swept-source optical coherence tomography study

      Purpose To assess variations in the iridocorneal angle width and iris volume in Chinese subjects using swept-source optical coherence tomography (SS-OCT). Methods Consecutive subjects, aged 40–80 years, with no previous ophthalmic problems were recruited from a population-based study of Chinese Singaporeans. All subjects underwent 360° SS-OCT (SS-1000 CASIA, Tomey Corporation, Nagoya, Japan) angle imaging and gonioscopy in one randomly selected eye in the dark. For each eye, 16 frames (11.25° apart) were selected for analysis from 128 cross-sectional images, and measurements of the trabecular iris space area 750 μm from the scleral spur (TISA750) and iris volume were ...

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    10. Improvement of visual acuity based on optical coherence tomography patterns following intravitreal bevacizumab treatment in patients with diabetic macular edema

      Improvement of visual acuity based on optical coherence tomography patterns following intravitreal bevacizumab treatment in patients with diabetic macular edema

      AIM: To report the visual outcome based on various patterns of optical coherence tomography (OCT) morphology in diabetic macular edema (DME), following treatment with anti-VEGF intravitreal bevacizumab (IVB) injection. METHODS: Sixty-seven consecutive subjects with centre involving DME underwent intravitreal injection of Bevacizumab (1.25 mg/0.05 mL) in this retrospective, comparative, non randomized study. The DME was classified into one of four categories:focal, diffuse, focal cystoid and neurosensory detachment based on OCT. Best corrected visual acuity (BCVA), macular appearance, and OCT findings were used to decide whether the subject should have a repeat injection of intravitreal bevacizumab. Outcome ...

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    11. Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy

      Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy

      AIM: To discuss and compare the fundus autofluorescence (FAF) and optical coherence tomography (OCT) in acute or chronic central serous chorioretinopathy (CSCR). METHODS: Medical records of 100 cases of CSCR were reviewed. Acute and chronic cases were evaluated according to the duration of decreased visual acuity, serous retinal detachment (RD) and focal leakage on fluorescein angiography (FA). Chi-square test was used for statistical analysis. RESULTS: Forty cases had acute and 60 cases had chronic CSCR. FAF showed focal hypo-autofluorescence in 34 (85%) and iso-autofluorescence in 6 (15%) of acute cases and hypo-autofluorescence in 51 (85%), hyper-autofluorescence in 6 (10%) and ...

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    12. Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Background To investigate the image quality of wide-angle cross-sectional and reconstructed fundus images based on ultra-megahertz swept-source Fourier domain mode locking (FDML) OCT compared to current generation diagnostic devices. Methods A 1,050 nm swept-source FDML OCT system was constructed running at 1.68 MHz A-scan rate covering approximately 70° field of view. Twelve normal eyes were imaged with the device applying an isotropically dense sampling protocol (1,900 × 1,900 A-scans) with a fill factor of 100 %. Obtained OCT scan image quality was compared with two commercial OCT systems (Heidelberg Spectralis and Stratus OCT) of the same 12 eyes ...

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    13. Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Purpose: To describe the imaging characteristics and to investigate the prognostic factors of acute retinal pigment epitheliitis. Methods: In this retrospective observational case series, a total of 18 patients (18 eyes) with acute retinal pigment epitheliitis were included. The features of acute retinal pigment epitheliitis were analyzed by spectral-domain optical coherence tomography (SD-OCT). Results: SD-OCT images obtained at baseline revealed abnormal reflectivity in the retinal pigment epithelium (RPE) inner layer in every case (18 eyes, 100%). The line corresponding to the RPE inner layer, the inner segment ellipsoid (ISe), showed abnormal reflectivity in 16 cases (89%). Among patients with ISe ...

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    14. Influence of image compression on the interpretation of spectral-domain optical coherence tomography in exudative age-related macular degeneration

      Influence of image compression on the interpretation of spectral-domain optical coherence tomography in exudative age-related macular degeneration

      Purpose To evaluate the effect of image compression of spectral-domain optical coherence tomography (OCT) images in the examination of eyes with exudative age-related macular degeneration (AMD). Methods Thirty eyes from 30 patients who were diagnosed with exudative AMD were included in this retrospective observational case series. The horizontal OCT scans centered at the center of the fovea were conducted using spectral-domain OCT. The images were exported to Tag Image File Format (TIFF) and 100, 75, 50, 25 and 10 % quality of Joint Photographic Experts Group (JPEG) format. OCT images were taken before and after intravitreal ranibizumab injections, and after relapse ...

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    15. Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter

      Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter

      IM: To compare the RTVue spectral optical coherence tomography (SD-OCT), Sirius Scheimpflug-Placido topographer, Lenstar optical low coherence reflectometry (OLCR) and ultrasound pachymetry (USP) devices in terms of their agreement and repeatability of measuring central corneal thickness (CCT). METHODS: In this prospective study, 50 eyes of 50 patients were included. Three repeated measures were obtained using SD-OCT, Scheimpflug-Placido topographer and USP and five measurements were determined with the OLCR. Bland-Altman plots were used to assess agreement among the instruments, and 95% limits of agreement (LoA) for each comparison were calculated. Intra-examiner repeatability was assessed using intraclass correlation coefficients (ICCs). RESULTS: The ...

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    16. A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      To estimate the potential outcomes of spectral domain optical coherence tomography (SD-OCT) screening among African American patients in the US, a decision analysis model was used to synthesize the current evidence and to project visual function outcomes over a 10 year time horizon. The secondary intent of this study was to assess the cost of the screening implementation. Methods: Using a Monte Carlo micro-simulation model with a 10 year time horizon, we evaluated the impact of SD-OCT screening among African American patients on visual field loss and evaluated the associated costs of screening and treatment. Results: Based upon the model ...

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    17. Scanning laser ophthalmoscopy and optical coherence tomography imaging of spectacular ecdysis in the corn snake (Pantherophis guttatus) and the California king snake (Lampropeltis getulus californiae) - Cazalot - 2014 - Veterinary Ophthalmology

      Scanning laser ophthalmoscopy and optical coherence tomography imaging of spectacular ecdysis in the corn snake (Pantherophis guttatus) and the California king snake (Lampropeltis getulus californiae) - Cazalot - 2014 - Veterinary Ophthalmology

      Purpose One of the singularities of the eyes of snakes is the presence of the spectacle, a transparent and vascularized integument covering the cornea. The spectacle is completely renewed during ecdysis. Combined scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and conventional macrophotography were used to image this phenomenon. Material and Methods A spectral OCT/SLO examination and macrophotography were performed in four healthy adult corn snakes ( Pantherophis guttatus ) and one healthy adult California king snake ( Lampropeltis getulus californiae ) the day before the start of ecdysis and then daily during ecdysis. Results In all animals, ecdysis lasted 5 days. The ...

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    18. Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography (SD-OCT) is a widely used method to observe retinal layers and follow pathological events in human. Recently, this technique has been adapted for animal imaging. This non-invasive technology brings a cross-sectional visualization of the retina, which permits to observe precisely each layer. There is a clear expansion of the use of this imaging modality in rodents, thus, a precise characterization of the different outer retinal layers observed by SD-OCT is now necessary to make the most of this technology. The identification of the inner strata until the outer nuclear layer has already been clearly established, while ...

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      Mentions: Michel Pâques
    19. Voxeleron introduces Orion, advanced optical coherence tomography (OCT) analysis software.

      Voxeleron introduces Orion, advanced optical coherence tomography (OCT) analysis software.

      Voxeleron introduces Orion, advanced optical coherence tomography (OCT) analysis software. Orion is fully-automated soft-ware, rapidly and accurately segmenting seven retinal layers in OCT images. The limited functionality of existing OCT analysis tools has meant that only two or three retinal layers are analyzed, despite the overwhelming evidence for the clinical importance of the inner retinal layers in disease detection and prognosis. Orion address-es exactly this technology gap, providing researchers much needed biomarkers for the early detection and prognosis of ophthalmic and neurological diseases. Orion is device independent, processing data from different OCT vendors. Orion will be featured in two posters ...

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      Mentions: Voxeleron
    20. Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

      Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

      Background: The aim of this study was to evaluate the reproducibility of the posterior pole asymmetry analysis (PPAA) in glaucomatous eyes and healthy controls in comparison to retinal nerve fiber layer measurements (RNFL) with spectral domain optical coherence tomography (SD-OCT). Patients and Methods: Prospectively, in a single session by one operator, three measurements were taken of the retinal thickness with the PPAA and three measurements of the RNFL with the eye-tracker function of the Heidelberg Spectralis SD-OCT. Results: The mean intraclass correlation coefficient (ICC) and lower confidence intervals (in parentheses) for PPAA were 0.98 (0.96) in both healthy ...

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    21. Heidelberg completes CET programme

      Heidelberg completes CET programme

      Heidelberg Engineering has completed a three-month national peer discussion programme that provided OCT training for 300 practitioners. Peer discussion sessions entitled OCT in Acute Vision Loss took place in the Wirral, Oxford, Manchester, Sheffield, Hemel Hempstead, Leeds, Epsom and Wolverhampton. A variety of case studies and peer discussions were presented by Christopher Mody (pictured), Heidelberg Engineering’s clinical programme manager.

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    22. Anterior segment optical coherence tomography documentation of a case of topiramate induced acute angle closure

      We present a case report of a 31-year-old female patient who presented to us with a 1 day history of acute bilateral eye pain, blurred vision and headache. She was found to have a myopic shift, raised intraocular pressure (IOP) and shallow anterior chambers in both eyes. She had been commenced on oral topiramate 1 week previously. A number of investigations, including anterior segment optical coherence tomography (AS-OCT) were done and a diagnosis of topiramate induced bilateral acute angle closure (TiAAC) was made. Topiramate was discontinued and she was managed with topical and oral antiglaucoma medications, topical steroids and cyclopegics ...

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    23. Morphological changes in spectral domain optical coherence tomography guided bevacizumab injections in wet age-related macular degeneration, 12-months results

      Morphological changes in spectral domain optical coherence tomography guided bevacizumab injections in wet age-related macular degeneration, 12-months results

      Purpose: To describe retinal changes during Spectral Domain Optical Coherence Tomography (SD-OCT) guided bevacizumab treatment for neovascular age- related macular degeneration (AMD). Settings and Design: Single center observational study. Materials and Methods: We confirmed wet AMD in 47 eyes of 45 patients by fluorescein angiography and SD-OCT. After bevacizumab injection, we examined the patients at 4-week intervals. During each follow-up control, we performed SD-OCT and a complete ophthalmic examination. Criteria for reinjection were visual acuity loss of more than five ETDRS letters, and/or increase of central retinal thickness, sub-retinal fluid, intra-retinal fluid, pigment epithelium detachment. If reinjection criteria were ...

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