1. Articles in category: Ophthalmology

    577-600 of 6405 « 1 2 ... 22 23 24 25 26 27 28 ... 265 266 267 »
    1. University of Houston Receives NIH Grant for Optical Coherence Elastography of the Cornea

      University of Houston Receives NIH Grant  for Optical Coherence Elastography of the Cornea

      University of Houston Received a 2014 NIH Grant for $388,129 for Optical Coherence Elastography of the Cornea. The principal investigator is Kirill Larin. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement ...

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    2. UIUC Receives NIH Grant for Partnership for Primary Care Imaging

      UIUC Receives NIH Grant for Partnership for Primary Care Imaging

      University of Illinois at Urbana Champaign Received a 2014 NIH Grant for $933,337 for Partnership for Primary Care Imaging. The principal investigator is Stephen Boppart. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Primary Care Medicine, including Family Practice and Pediatrics, has traditionally relied on physical exam skills and simplistic instruments for critical diagnostic decision making, monitoring, and referral to medical specialists. The otoscope and ophthalmoscope are two historical and ubiquitous instruments that largely only illuminate and magnify tissue surfaces in the ear and eye, respectively. This Partnership will develop ...

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    3. Comparison of a MEMS-Based Handheld OCT Scanner With a Commercial Desktop OCT System for Retinal Evaluation

      Comparison of a MEMS-Based Handheld OCT Scanner With a Commercial Desktop OCT System for Retinal Evaluation

      Purpose: The goal of this study was to evaluate the ability of our handheld optical coherence tomography (OCT) scanner to image the posterior and anterior structures of the human eye, and especially the individual layers of the retina, and to compare its diagnostic performance with that of a fixed desktop commercial ophthalmic OCT system. Methods: We compared the clinical imaging results of our handheld OCT with a leading commercial desktop ophthalmic system (RTVue) used in specialist offices. Six patients exhibiting diabetes-related retinal pathology had both eyes imaged with each OCT system. Results: In both sets of images, the structural irregularities ...

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    4. Correlation Of Visual Field Defects And Optical Coherence tomography Finding in Migraine Patients

      Correlation Of Visual Field Defects And Optical Coherence tomography Finding in Migraine Patients

      Aim of work The aim of our work was to detect any structural or functional visual defects during and in between the attacks in patients with migraine. Patient and methods Sixty patients with migraine as well as sixty age and sex matched controls were included. All cases were subjected to full ophthalmological examination. Cases with any previously known optic nerve abnormalities or with history of increased intraocular pressure were excluded from this study. A full threshold 24-2 automated perimetry as well as optical coherence tomography (OCT) were performed for retinal nerve fiber layer (RNFL) thickness. Correlations between results of study ...

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    5. Update on choroidal vascular imaging using optical coherence tomography

      Update on choroidal vascular imaging using optical coherence tomography

      The choroid being the most vascular tissue plays an important role in nutrition of outer retinal structures as well as the visual function. Recent literature provides information about the choroidal thickness and its change in various chorioretinal diseases. Detailed assessment of choroidal vasculature is yet to be explored. This review evaluates the undergoing research in choroidal vascular imaging using various optical coherence tomography techniques such as en-face, phase variance, and swept-source. The authors also discuss automated segmentation of choroidal vessels and its application in choroidal assessment as well as future directions.

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    6. Scanning and processing using optical coherence tomography

      Scanning and processing using optical coherence tomography

      In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 ...

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    7. Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography

      Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography

      Background To assess the chorioretinal thickness changes using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the association between these structural changes and cognitive impairment in Alzheimer's disease (AD). Design Prospective, cross-sectional study Participants 31 eyes of 31 consecutive patients with AD and 30 eyes of 30 cognitively healthy age-matched control subjects were recruited Methods SD-OCT (RTVue-100) was used to measure the macular ganglion cell complex thickness (mGCC), outer retinal thickness (ORL), and the choroidal thickness (CT). Cognitive function was evaluated by Mini-Mental State examination (MMSE) on the same day of the optical examination. Main Outcome Measures chorioretinal thickness ...

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    8. Spectral Optical Coherence Tomography vs. fluorescein pattern for rigid gas-permeable lens fit

      Spectral Optical Coherence Tomography vs. fluorescein pattern for rigid gas-permeable lens fit

      Background : This study aimed to evaluate anterior segment spectral optical coherence tomography (AS SOCT) for assessing the lens-to-cornea fit of rigid gas-permeable (RGP) lenses. The results were verified with the fluorescein pattern method, considered the criterion standard for RGP lens alignment evaluations. Material and Methods : Twenty-six eyes of 14 patients were enrolled in the study. Initial base curve radius (BCR) of each RGP lens was determined on the basis of keratometry readings. The fluorescein pattern and AS SOCT tomograms were evaluated, starting with an alignment fit, and subsequently, with BCR reductions in increments of 0.1 mm, up to 3 ...

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    9. Achromatopsia: case presentation and literature review emphasising the value of spectral domain optical coherence tomography

      Achromatopsia: case presentation and literature review emphasising the value of spectral domain optical coherence tomography

      A literature review and case presentation are used to discuss the diagnostic value of spectral domain optical coherence tomography (SD-OCT) in the assessment and management of congenital achromatopsia. A 24-year-old Hispanic man presented to the clinic with a longstanding history of decreased vision and associated possible recent progression. A comprehensive eye examination and a battery of tests including SD-OCT, fundus photography, electroretinogram (ERG) and Farnsworth D-15 were completed. SD-OCT and photopic ERG confirmed the clinical diagnosis of congenital achromatopsia. There was the classic subfoveal flattened hyporeflective ‘punched out’ zone, resulting from an absence of inner segment/outer segment junction. SD-OCT ...

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    10. Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography

      Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography

      Purpose : To investigate posterior segment (PS) findings in the eye in patients with ankylosing spondylitis (AS). Methods : Eighty-four patients with AS and 63 healthy controls were enrolled. PS evaluations were performed using optical coherence tomography (OCT). Foveal thickness, peripapillary retinal nerve fiber layer thickness, macular volume, ganglion cell complex, and choroidal thickness (CT) values were compared between the groups . Results : Mean CT was higher in patients with AS (326.5 ± 71.5 µm) than in the healthy controls (286.2 ± 59.5 µm) ( p  = 0.001). There was no significant difference between patients with AS and the healthy control group ...

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    11. Evaluation of the macular choroidal thickness using spectral optical coherence tomography in patients with obstructive sleep apnea syndrome

      Evaluation of the macular choroidal thickness using spectral optical coherence tomography in patients with obstructive sleep apnea syndrome

      Background To assess the choroidal thickness (CT) in patients with obstructive sleep apnea syndrome (OSAS) and healthy controls. Design Prospective, cross-sectional study Participants 92 eyes of 92 patients with OSAS and 32 eyes of 32 age- and body mass index-matched healthy subjects were enrolled. Methods OSAS patients were further divided into mild, moderate and severe OSAS groups according to their apnea hypopnea index (AHI) values. The macular CT and peripapillary retinal nerve fiber layer (RNFL) thickness measurements of the subjects were obtained using spectral domain optical coherence tomography (RTVue-100, Optovue). The CT and RNFL thickness measurements of the groups were ...

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    12. 25th RCOphth Congress, President's Session paper: 25 years of progress in medical retina

      25th RCOphth Congress, President's Session paper: 25 years of progress in medical retina

      The quarter century since the foundation of the Royal College of Ophthalmologists has coincided with immense change in the subspecialty of medical retina, which has moved from being the province of a few dedicated enthusiasts to being an integral, core part of ophthalmology in every eye department. In age-related macular degeneration, there has been a move away from targeted, destructive laser therapy, dependent on fluorescein angiography to intravitreal injection therapy of anti-growth factor agents, largely guided by optical coherence tomography. As a result of these changes, ophthalmologists have witnessed a marked improvement in visual outcomes for their patients with wet ...

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    13. Spectral domain optical coherence tomography findings in eyes with acute ischaemic retinal whitening

      Spectral domain optical coherence tomography findings in eyes with acute ischaemic retinal whitening

      Acute retinal ischaemia presents in various forms depending on the type and location of the associated vascular occlusion. Cotton wool spots have been considered one manifestation of ischaemia and represent swelling in the nerve fibre layer. However, clinical retinal whitening also occurs in areas not affected by cotton wool spots, and has distinguishing spectral domain optical coherence tomography (SD-OCT) features. We present SD-OCT findings of hyper-reflectivity and thickening in four eyes with representative retinal arterial or retinal venous occlusions, specifically branch retinal artery occlusion, central retinal vein occlusion, Purtscher-like retinopathy and ophthalmic artery occlusion. The spectrum of retinal ischaemia from ...

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    14. Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Purpose: To analyze in vivo the dynamic changes induced by different artificial tears (ATs) in the precorneal tear film (PCTF) and lower tear meniscus (LTM) by using a Spectral-domain anterior segment optical coherence tomography (SD-OCT). Methods: We prospectively examined forty-two normal human eyes by using SD-OCT imaging. On the day before OCT imaging, all enrolled subjects were evaluated for abnormalities of ocular surface. All tear film images were obtained before and after instillation of three different types of ATs (mucomimetic, lipid-based and saline) in five serial scans: immediately (within 30 seconds), at the 1st, at the 5th, at the 10th ...

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    15. Reliability of manual measurements of corneal thickness obtained from healthy canine eyes using spectral-domain optical coherence tomography (SD-OCT)

      Reliability of manual measurements of corneal thickness obtained from healthy canine eyes using spectral-domain optical coherence tomography (SD-OCT)

      The purpose of this study was to manually measure corneal thickness in canine eyes using a spectral-domain optical coherence tomography (SD-OCT) device and to assess intra- and inter-observer reliability of this technique. Twenty healthy dogs with a mean age of 4.7 y were examined. A 6-mm corneal pachymetry protocol was carried out by 1 operator using 1 SD-OCT device in both eyes of each animal. Measurements were obtained manually and in duplicate by 2 independent investigators (> 24 h apart), using the built-in caliper function. Measurements included epithelial thickness (ET), non-epithelial thickness (NET), and central corneal thickness (CCT). The overall ...

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    16. Reproducibility of Optical Coherence Tomography Retinal Nerve Fiber Layer Thickness Measurements Before and After Pupil Dilation

      Reproducibility of Optical Coherence Tomography Retinal Nerve Fiber Layer Thickness Measurements Before and After Pupil Dilation

      Purpose: To evaluate the intra- and interobserver reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements before and after pupil dilation using spectral-domain optical coherence tomography (SD-OCT). Methods: In this observational case series, 44 eyes of 44 healthy subjects were scanned by two trained operators on the same day, using Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA, USA). Three scans were obtained before and after pupil dilation by each operator. Mean ± standard deviation (SD) and coefficient of variation (CV) were used for description of results and variation of measurements respectively. Intraclass correlation coefficients (ICC) and Bland-Altman plots were used ...

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    17. Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children

      Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children

      Purpose To determine the intra- and intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) measures using handheld optical coherence tomography (OCT) in sedated children. Design Prospective cross-sectional and longitudinal study Methods Children undergoing sedation for a clinically indicated MRI for an optic pathway glioma and or Neurofibromatosis type 1 (NF1) had multiple 6 x 6 mm volumes (isotropic 300x300 or non-isotropic 1000x100 samplings) acquired over the optic nerve. Children with two handheld OCT sessions within 6 months were included in the intervisit cohort. The intra- and inter-visit coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated for ...

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    18. Deferoxamine retinopathy: spectral domain-optical coherence tomography findings

      Deferoxamine retinopathy: spectral domain-optical coherence tomography findings

      Background To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration. Case presentation A 34-year-old man with thalassemia major complained of nyctalopia and decreased vision following high-dose intravenous deferoxamine to treat systemic iron overload. Fundus examination revealed multiple discrete hypo-pigmented lesions at the posterior pole and mid-peripheral retina. Recovery was partial following cessation of desferrioxamine six weeks later. A follow-up SD-OCT showed multiple accumulated hyper-reflective deposits primarily in the choroid, retina pigment epithelium (RPE), and inner segment and outer segment (IS/OS) junction. Conclusion Deferoxamine retinopathy primarily targets the ...

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    19. Long-term outcomes of optical coherence tomography-guided transepithelial phototherapeutic keratectomy for the treatment of anterior corneal scarring

      Long-term outcomes of optical coherence tomography-guided transepithelial phototherapeutic keratectomy for the treatment of anterior corneal scarring

      Aim To report the long-term outcomes of optical coherence tomography (OCT)-guided transepithelial phototherapeutic keratectomy (PTK) for the management of anterior corneal scarring. Methods The charts of 60 patients (64 eyes) who underwent OCT-guided transepithelial PTK for anterior corneal scarring were retrospectively reviewed. The procedure involved a preoperative OCT-measured depth of treatment calculation to reduce or eliminate corneal scarring, followed by a combined myopic and hyperopic transepithelial excimer laser treatment profile established to attain the desired refractive result. The main outcome measures consisted of change in best spectacle-corrected visual acuity (BSCVA), change in OCT-measured parameters, and change in corneal topography ...

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    20. Update on Retinal Vessel Structure Measurement with Spectral-Domain Optical Coherence Tomography

      Update on Retinal Vessel Structure Measurement with Spectral-Domain Optical Coherence Tomography

      This study was conducted to demonstrate a new scan method for retinal vessel structure measurement in a specific region of fundus (zone B) using spectral-domain optical coherence tomography (SD-OCT), and to assess its reliability. One superior temporal retinal vessel pair passing through a concentric ring (zone B), which was defined between half and one disc distance from the optic disc border, was chosen for the measurement using a volume scan in SD-OCT. On the SD-OCT image, retinal arteriolar outer diameter (RAOD), retinal arteriolar lumen diameter (RALD), retinal venular outer diameter (RVOD) and retinal venular lumen diameter (RVLD) were measured. Retinal ...

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    21. Comparison of conjunctival graft thickness after primary and recurrent pterygium surgery: Anterior segment optical coherence tomography study

      Comparison of conjunctival graft thickness after primary and recurrent pterygium surgery: Anterior segment optical coherence tomography study

      Objective: The objective of the following study is to compare the conjunctival graft thickness measured with anterior segment optical coherence tomography (OCT) after primary and recurrent pterygium excision. Design: Prospective, interventional and comparative study. Participants: A total of 20 eyes of 20 patients with primary pterygium (primary group) and 20 eyes of 20 patients with recurrent pterygium (recurrent group) were enrolled. Materials and Methods: All patients underwent pterygium excision with conjunctival autograft transplantation. Conjunctival graft thickness was measured at 1 week, 1 month and 3 months after surgery using the Visante-OCT (Carl-Zeiss Meditec, Dublin, CA, USA). Main outcome measure was ...

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    22. Morphology of functioning trabeculectomy blebs using anterior segment optical coherence tomography

      Morphology of functioning trabeculectomy blebs using anterior segment optical coherence tomography

      Purpose: To image trabeculectomy blebs using anterior segment optical coherence tomography (AS-OCT), and to correlate the bleb morphologic features at one month postoperatively with bleb function at six months. Materials and Methods: This prospective, observational study included 56 eyes undergoing trabeculectomy with MMC, followed up for minimum of six months. Postoperatively, bleb imaging was done using AS-OCT at one and six month. Bleb morphology was assessed for bleb wall reflectivity, bleb pattern in multiform reflectivity, visibility of drainage route and presence of hyper-reflectivity area. Bleb function was considered successful if IOP was <18 mmHg without medication at six month. Bleb ...

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    23. Is the ISNT rule helpful?

      Is the ISNT rule helpful?

      We’re taught from a very young age that, in science, the laws of nature never change. Then, we learn in college physics that, in fact, these laws actually change a great deal. The hallmark example of this would be the comparison of the laws governing the planets to the laws governing subatomic particles. I’ll admit that watching the reprise of the TV series “Cosmos” has been a guilty pleasure of mine as of late, but enough about that. Are there any absolute laws for glaucoma other than the broad few that govern its definition? Well, maybe not. Think ...

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