1. Articles in category: Ophthalmology

    577-600 of 5983 « 1 2 ... 22 23 24 25 26 27 28 ... 248 249 250 »
    1. Macular Choroidal Thickness and Volume of Eyes with Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography

      Macular Choroidal Thickness and Volume of Eyes with Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography

      Purpose To investigate the choroidal thickness/volume of eyes with reticular pseudodrusen using high-penetration swept-source optical coherence tomography (SS-OCT) and to evaluate the choroidal vasculature changes using en face images. Design Prospective cross sectional study. Methods Thirty-eight eyes with reticular pseudodrusen and 14 normal eyes were studied with prototype SS-OCT. Eyes with reticular pseudodrusen were classified into 3 subgroups: eyes without late age-related macular degeneration (AMD) (group1), eyes with neovascular AMD (group2), and eyes with geographic atrophy (group3). Mean regional choroidal thickness/volume measurements were obtained by three-dimensional (3D) raster scanning. The choroidal vascular area was measured using en face ...

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    2. Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma

      Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma

      Background: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL). Methods: The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes. Results: The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two ...

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    3. Methods And Systems For Characterizing Angle Closure Glaucoma For Risk Assessment Or Screening

      Methods And Systems For Characterizing Angle Closure Glaucoma For Risk Assessment Or Screening

      A method is proposed for analysing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing ...

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    4. Reproducibility of horizontal extraocular muscle insertion distance in anterior segment optical coherence tomography and the effect of head position

      Reproducibility of horizontal extraocular muscle insertion distance in anterior segment optical coherence tomography and the effect of head position

      Purpose To investigate the reproducibility of horizontal extraocular muscle insertion distance measurements in anterior segment optical coherence tomography (AS-OCT) and to evaluate the effect of eye position on the measurement. Methods The right eyes of 30 healthy young subjects underwent AS-OCT. Varying eye positions were used and the muscle insertion distance was measured by two independent examiners who each measured the insertion distance twice. The measurement was performed for the lateral rectus and medial rectus muscles with the eye rotated 40°, 50°, and 60° to the midline of the instrument. Reproducibility was evaluated with the intraclass correlation coefficient (ICC) and ...

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      Mentions: Samsung
    5. Optical coherence tomography characteristics of epi-iridic membrane in a child with recurrent hyphema and presumed juvenile xanthogranuloma

      Optical coherence tomography characteristics of epi-iridic membrane in a child with recurrent hyphema and presumed juvenile xanthogranuloma

      We report a case of spontaneous hyphema in a 6-month-old girl with no history of trauma and no visible iris mass. Subtle green-blue heterochromia was noted in the right eye. The iris crypts in the right eye appeared flattened by a thin, transparent layer on the iris surface. Anterior segment optical coherence tomography (AS-OCT) disclosed a thin homogenous membrane overlying the entire iris surface in the right eye. Fluorescein angiography revealed diffuse hyperfluorescence without neovascularization. These features were suggestive of diffuse iris juvenile xanthogranuloma. Sub-Tenon's triamcinolone acetate plus topical corticosteroids eyedrops resolved the condition within 1 month

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    6. Evaluation of the macula, retinal nerve fiber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography

      Evaluation of the macula, retinal nerve fiber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography

      Objective : To evaluate the macular, retinal nerve fiber layer (RNFL) and choroidal thickness alterations by using spectral-domain optical coherence tomography (SD-OCT) in preeclampsia and compare with healthy pregnant and healthy non-pregnant controls. Method : The study population included healthy pregnant control group ( n : 25), healthy non-pregnant control group ( n : 26) and study group with preeclampsia ( n : 27). Retinal thickness parameters were measured by SD-OCT. Results : There was a statistically significant difference among all of the groups for choroidal thickness ( p  < 0.001). Choroidal thickness in preeclamptic women was significantly thinner than healthy pregnant women. The most thick choroid layer was detected ...

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    7. Parry-romberg syndrome studied by spectral-domain optical coherence tomography

      Parry-romberg syndrome studied by spectral-domain optical coherence tomography

      Parry-Romberg syndrome is a rare disorder characterized by progressive hemifacial atrophy. Ophthalmic findings are characterized by enophthalmos, strabismus, nerve palsies, anisometropia, glaucoma, and angle abnormalities. Vision loss has also been reported due to retinal changes such as venous dilatation, disc edema, retinal edema, and retinal folds. The authors describe a case of Parry-Romberg syndrome with retinal alterations but a normal macula on spectral-domain optical coherence tomography

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    8. Anterior segment optical coherence tomography in evaluation of severe fungal keratitis infections treated by corneal crosslinking

      Anterior segment optical coherence tomography in evaluation of severe fungal keratitis infections treated by corneal crosslinking

      Purpose: Anterior segment optical coherence tomography (OCT) is a relevant diagnostic tool in the evaluation of corneal changes following corneal crosslinking (CXL) treatment in patients infected by a severe fungal corneal infection. Methods: Two patients with severe fungal keratitis that was unresponsive to medical treatment were treated with CXL. Corneal melting was present in all cases. Anterior segment OCT showed the preoperative depth and extension of the infiltrate and the modification during the follow-up. Results: Blockage of the melting was achieved in one patient and one patient developed a corneal perforation. Anterior segment OCT allowed control of the evolution of ...

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      Mentions: Jorge L. Alio
    9. Tear meniscus volume changes in dacryocystorhinostomy evaluated with quantitative measurement using anterior segment optical coherence tomography

      Tear meniscus volume changes in dacryocystorhinostomy evaluated with quantitative measurement using anterior segment optical coherence tomography

      PURPOSE: To evaluate tear meniscus (TM) changes in external dacryocystorhinostomy (ex-DCR) with quantitative measurement on tear meniscus height (TMH), area (TMA) and volume (TMV) using an anterior segment optical coherence tomography (AS-OCT). METHODS: Twenty-one patients of 25 eyes (11 males and 10 females) with a primary acquired nasolacrimal duct obstruction (PANDO) who received ex-DCR from May 2010 to April 2011 were evaluated prospectively on their TMH, TMA, and TMV changes by AS-OCT. Measurements were performed before surgery (Pre), and 2 weeks (2W), 2 months (2M), and 6 months (6M) after surgery. Data was analyzed using Kruskal-Wallis test, Wilcoxon signed-rank test ...

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    10. Automated Segmentation of Optic Nerve Head Structures with Optical Coherence Tomography

      Automated Segmentation of Optic Nerve Head Structures with Optical Coherence Tomography

      Purpose: To quantify and characterise the difference between automated and manual segmentation of optic nerve head structures with spectral domain-optical coherence tomography (SD-OCT). Methods: Optic nerve head radial scans in 107 glaucoma patients and 48 healthy controls were conducted with SD-OCT. Independent segmentations of the internal limiting membrane (ILM) and Bruch's membrane opening (BMO) were performed manually with custom software and with an automated algorithm in each radial scan. The minimum distance between BMO and ILM, termed BMO-minimum rim width (BMO-MRW) was calculated with each segmentation method. Absolute differences between automated and manual segmentations of ILM (ΔILM) and BMO ...

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    11. Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopathy

      Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopathy

      Purpose: To describe the appearance of acute syphilitic posterior placoid chorioretinitis, a rare ocular manifestation of syphilis, on spectral domain optical coherence tomography (SD OCT) both before and after treatment. Methods: Ophthalmic examination and imaging studies of 30 eyes of 19 confirmed cases were analyzed both at the time of presentation and at each follow-up visit. Patients with SD OCT and fluorescein angiography at the time of presentation, and at least three documented follow-up visits after initiation of therapy, were included in the study. Standard treatment of neurosyphilis was given to each patient, including 4 million units of penicillin G ...

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    12. Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes

      Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes

      We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the validity of the measurements. In accordance with Murray’s law, the log-log regression coefficient between vessel diameter and blood flow was found to be ~3. The blood’s velocity scaled linearly with the vessel diameter at higher diameters (> 60 µm), but showed a clear divergence from the linear dependence at ...

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    13. Eye Biometry Using Quantitative 3-D OCT

      Eye Biometry Using Quantitative 3-D OCT

      Cataracts cause the crystalline lens of the eye to progressively lose its transparency, which decreases vision.   It is one of the major causes of vision loss in our aging population.   Modern cataract surgery involves the replacement of the cloudy lens with an intraocullar lens (IOL).  IOL designs are becomeing more sophisticated, with benefits such as aspheric surfaces, multifocality, and the capability to change position ore shape to restore accommodation.  

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    14. Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema

      Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema

      Purpose To study retrospectively the characteristics of residual indocyanine green (ICG) fluorescence after ICG-assisted vitrectomy and the association with spectral-domain optical coherence tomography (SD-OCT) findings in diabetic macular oedema (DMO). Methods Thirteen consecutive eyes of 12 patients for whom fundus near-infrared fluorescence and 20° retinal sectional images were obtained using HRA2 and Spectralis OCT, respectively, 5 days after vitrectomy combined with ICG-assisted inner limiting membrane peeling for DMO. The relationship between the characteristics of the ICG hyperfluorescence and the cystoid spaces in the outer plexiform layer (OPL) on SD-OCT images was evaluated. Results A total of 390 well-demarcated areas of ...

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    15. OCT evaluation of neuroprotective effects of tafluprost on retinal injury after intravitreal injection of endothelin-1 in the rat eye

      OCT evaluation of neuroprotective effects of tafluprost on retinal injury after intravitreal injection of endothelin-1 in the rat eye

      Purpose: To determine whether optical coherence tomography (OCT) is a useful technique to monitor retinal damage and to evaluate the neuroprotective effect of topical tafluprost in a rat model of intravitreal endothelin-1 (ET-1) injection. Methods: A single intravitreal injection of ET-1 (0.2-200 pmol/eye) was performed in one eye. OCT imaging was performed until 2 weeks after ET-1 injection. Subsequently, an intravitreal injection of ET-1 (20 pmol/eye) was performed in one eye of each rat, which was followed by topical instillation of tafluprost or saline once daily for 4 weeks. OCT imaging was performed until 4 weeks after ...

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    16. Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

      Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

      Purpose:To evaluate early diabetes-induced changes in retinal thickness and microvasculature in a type II diabetic mouse model using OCT/OMAG. Methods:22 week old obese BTBR mice (OB, n=10) and wild type control mice (WT, n=10) were imaged. Three-dimensional data were captured with OCT using an ultrahigh sensitive OMAG scanning protocol for 3D angiography of the retina and dense A-scan protocol for measurement of the total retinal blood flow (RBF) rate. The thickness of the nerve fiber layer (NFL) and NFL to inner plexiform layer (IPL) were measured and compared between OB and WT mice. The linear ...

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    17. Predicting Transepithelial Phototherapeutic Keratectomy Outcomes Using Fourier Domain Optical Coherence Tomography

      Predicting Transepithelial Phototherapeutic Keratectomy Outcomes Using Fourier Domain Optical Coherence Tomography

      PURPOSE:: The aim of this study was to use Fourier domain optical coherence tomography to predict transepithelial phototherapeutic keratectomy outcomes. METHODS:: This is a prospective case series. Subjects with anterior stromal corneal opacities underwent an excimer laser phototherapeutic keratectomy (PTK) combined with a photorefractive keratectomy using the VISX S4 excimer laser (AMO, Inc, Santa Ana, CA). Preoperative and postoperative Fourier domain optical coherence tomography images were used to develop a simulation algorithm to predict treatment outcomes. Main outcome measures included preoperative and postoperative uncorrected distance visual acuities and corrected distance visual acuity. RESULTS:: Nine eyes of 8 patients were treated ...

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    18. Visual Involvement in MS: Optic Neuritis and Optical Coherence Tomography

      Visual Involvement in MS: Optic Neuritis and Optical Coherence Tomography

      This optic neuritis and optical coherence tomography multiple sclerosis webcast identifies the most current clinical trials, treatment options, and the use of optical coherence tomography in patients with multiple sclerosis. To learn more about the Multiple Sclerosis Virtual Grand Rounds series or to claim CME credit, visit

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      Mentions: Cleveland Clinic
    19. Using spectralis and stratus optical coherence tomography devices to analyze the retinal nerve fiber layer in patients with open-angle glaucoma

      Using spectralis and stratus optical coherence tomography devices to analyze the retinal nerve fiber layer in patients with open-angle glaucoma

      BACKGROUND: During the study at the Ophthalmology Clinic of Wroclaw Medical University retinal nerve fiber layer (RNFL) thickness was examined in 35 patients with open-angle glaucoma. OBJECTIVES: The aim of the study was to analyse RNFL thickness measurements by 2 different optical coherence tomography (OCT) devices. MATERIAL AND METHODS: The study group consisted of 35 patients with open-angle glaucoma (aged 48-76 years, including 20 women and 15 men - 70 eyes) with intraocular pressure below 19 mm Hg, treated pharmacologically. The subjects were examined using a Stratus Time Domain OCT (TD-OCT), produced by Zeiss, and a Spectralis Spectral Domain OCT (SD-OCT ...

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    20. Optical Coherence Tomography as a Biomarker in Clinical Trials for Ophthalmology and Neurology (Book Chapter)

      Optical Coherence Tomography as a Biomarker in Clinical Trials for Ophthalmology and Neurology (Book Chapter)

      In the past, clinical trials in neuro-ophthalmology have focused upon functional endpoints including Snellen visual acuity and visual field testing, both of which may have significant test/retest variability because of their dependence upon subject alertness and cognitive function. The introduction of optical coherence tomography (OCT) into the practice of clinical ophthalmology has now extended into clinical trials in both ophthalmology and neurology. Recent advances in the resolution and reproducibility of spectral-domain OCT have now produced algorithms that measure the structural integrity of the optic nerve and retina. OCT is in vivo histopathology and the qualitative and quantitative metrics of ...

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    21. Handbook of Retinal OCT: Optical Coherence Tomography, 1st Edition (Textbook)

      Handbook of Retinal OCT: Optical Coherence Tomography, 1st Edition (Textbook)

      With Handbook of Retinal OCT , you can master the latest imaging methods used to evaluate retinal disease, uveitis, and optic nerve disorders. Ideal at any stage of your career, this easy-to-use, clinically oriented handbook provides a quick, templated, and portable guide for the interpretation of Optical Coherence Tomography scans. Key Features: Locate answers quickly with templated chapters-each focused on one specific diagnosis or group of diagnoses with a particular OCT appearance; Adopt the latest techniques for evaluating age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, and much more; See how the full spectrum of diseases presents through approximately 370 illustrations ...

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    22. Spontaneous resolution of vitreomacular traction demonstrated by spectral-domain optical coherence tomography

      Spontaneous resolution of vitreomacular traction demonstrated by spectral-domain optical coherence tomography

      Purpose To evaluate the natural course of idiopathic vitreomacular traction (VMT) with spectral-domain optical coherence tomography (SDOCT) from the vitreomacular adhesion (VMA) stage to the spontaneous resolution of VMT. Design Prospective observational case series. Methods We studied the natural course of idiopathic VMT in 46 eyes (46 patients) divided into those that proceeded to spontaneous VMT resolution (12 cases) and those that remained at the VMT stage (34 cases). All patients were examined with SDOCT at regular three-monthly intervals. We recorded the vitreomacular angle of VMA nasally and temporally, the horizontal diameter of VMA, macular thickness, visual acuity, photoreceptor layer ...

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    23. Imaging Lens Deposits in Exfoliation Syndrome

      Imaging Lens Deposits in Exfoliation Syndrome

      The purpose of this study is to use a special eye imaging technique, anterior segment optical coherence tomography (AS-OCT), to image the lens (the curved, transparent part of the eye that helps you to see clearly by directing images of light onto the back of your eye) and note any changes in exfoliation syndrome. Exfoliation syndrome is a common condition that has many ways of showing up in the eye, including the formation of deposits in the eye, shakiness of the lens that can complicate cataract surgery, and a higher chance of developing a type of glaucoma called exfoliation glaucoma ...

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      Mentions: Duke University
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