1. Articles in category: Ophthalmology

    577-600 of 8378 « 1 2 ... 22 23 24 25 26 27 28 ... 347 348 349 »
    1. Optical Coherence Tomography in Multiple Sclerosis

      Optical Coherence Tomography in Multiple Sclerosis

      Retinal optical coherence tomography (OCT) has recently become a vital tool for clinicians and researchers in ophthalmology and, increasingly, in neurology. Optical coherence tomography is quickly and easily performed, well-tolerated by patients, and allows high-resolution viewing of unmyelinated axons and other retinal structures in vivo. These factors have led OCT to find favor as a method of quantifying neuroaxonal loss in multiple sclerosis (MS), and the increasing acceptance of the anterior visual pathway as a model to investigate MS in humans. In this short review, the authors discuss OCT findings in MS research, and the relationships of these structural findings ...

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    2. Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography

      Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography

      Optical coherence tomography (OCT) dramatically changed the way of diagnostic assessment in retinal diseases during the last years. Using this technique in-vivo in-depth analysis of the retina and its layers is possible. Since animal research is changing by intrinsic and extrinsic pressure to animal-( in-vivo )-free methods, we adapted OCT-measurements to organotypic cultures. An easy to use protocol was generated to assess standardized OCT assessments in organotypic culture. First, two custom-made devices need to be made to change any commercially available OCT for examinations in humans into a device allowing ex-vivo analyses of organotypic culture. The modification is feasible within ...

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    3. The Diagnostic Accuracy of Optical Coherence Tomography Angiography for Neovascular Age-Related Macular Degeneration: A Comparison with Fundus Fluorescein Angiography

      The Diagnostic Accuracy of Optical Coherence Tomography Angiography for Neovascular Age-Related Macular Degeneration: A Comparison with Fundus Fluorescein Angiography

      Purpose. To describe the morphological characteristics and efficacy of OCTA in detecting CNV in nAMD. We retrospectively reviewed 53 patients (86 eyes) with suspected CNV secondary to wet AMD. All the patients underwent a multimodal assessment for CNV. Two independent readers calculated the sensitivity and specificity of OCTA in detecting CNV compared with FA. A qualitative analysis of OCTA was also performed to describe the morphological appearance of CNV. Among 86 eyes of 53 patients, 52 eyes were diagnosed as having CNV based on the FA imaging analysis. According to FA, CNV was classified as classic in 28 eyes, predominantly ...

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    4. High-Resolution Optical Coherence Tomography–Guided Donor Tissue Preparation for Descemet Membrane Endothelial Keratoplasty Using the Reverse Big Bubble Technique

      High-Resolution Optical Coherence Tomography–Guided Donor Tissue Preparation for Descemet Membrane Endothelial Keratoplasty Using the Reverse Big Bubble Technique

      Purpose: The aim of this study was to assess the feasibility of high-resolution spectral domain optical coherence tomography (HR-SDOCT) to guide donor tissue preparation in Descemet membrane endothelial keratoplasty using the reverse big bubble technique. Methods: Three corneoscleral discs were included in this ex vivo experimental study. A 27-G cannula was introduced into each cornea at the periphery by 3 different surgeons. Each surgeon attempted to achieve the ideal depth (pre-Descemetic plane) of the tip of the cannula for air injection to produce the reverse big bubble to separate the Descemet membrane (DM) from the posterior stroma. A supine optical ...

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    5. The fundus photo has met its match: optical coherence tomography and adaptive optics ophthalmoscopy are here to stay

      The fundus photo has met its match: optical coherence tomography and adaptive optics ophthalmoscopy are here to stay

      Purpose Over the past 25 years, optical coherence tomography (OCT) and adaptive optics (AO) ophthalmoscopy have revolutionised our ability to non-invasively observe the living retina. The purpose of this review is to highlight the techniques and human clinical applications of recent advances in OCT and adaptive optics scanning laser/light ophthalmoscopy (AOSLO) ophthalmic imaging. Recent findings Optical coherence tomography retinal and optic nerve head (ONH) imaging technology allows high resolution in the axial direction resulting in cross-sectional visualisation of retinal and ONH lamination. Complementary AO ophthalmoscopy gives high resolution in the transverse direction resulting in en face visualisation of retinal ...

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    6. Neuroretinal rim in non-glaucomatous large optic nerve heads: a comparison of confocal scanning laser tomography and spectral domain optical coherence tomography

      Neuroretinal rim in non-glaucomatous large optic nerve heads: a comparison of confocal scanning laser tomography and spectral domain optical coherence tomography

      Background/aims To compare margin-based rim area measurements from confocal scanning laser tomography (CSLT) with Bruch's membrane opening (BMO)-based measurements from spectral domain optical coherence tomography (SD-OCT) by analysis of a group of non-glaucomatous eyes with large optic discs, so-called macrodiscs (disc size >2.45 mm 2 in CSLT). Objective is to create a reference base for large optic nerve heads in SD-OCT diagnostics. Methods 102 eyes received CSLT and SD-OCT measurements and clinical examination on the same day. Visual field testing confirmed absence of glaucomatous defects. Statistical and correlation analysis was performed for rim area by CSLT ...

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    7. Method and device for detecting deposits in the eye

      Method and device for detecting deposits in the eye

      A method and devices for detecting deposits, in particular amyloid plaques, in the eye, in particular in the human eye. The subject is an optical method for detecting deposits, in particular .beta.-amyloid, in the retina, which is locally resolved and wherein the local resolution is better than the layer thickness of individual layers of the retina. The invention includes a device for optically detecting .beta.-amyloid in the retina, which generates a locally resolved image of the retina and wherein the local resolution is better than the layer thickness of individual layers of the retina.

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    8. Combination optical and ultrasonic imaging of an eye

      Combination optical and ultrasonic imaging of an eye

      A method and apparatus are disclosed for integrating optical coherence tomography (OCT) and very high frequency ultrasound (VHFU) imaging systems. An OCT probe and reference arm are mounted along with an ultrasound probe on a carriage capable of rotational, linear, and/or arcuate motion. The probe carriage may be immersed in water or other suitable medium. The OCT and VHFU probes move about the cornea surface such that the probe axes are substantially perpendicular relative to the cornea surface throughout a scan. The probes are able to be scanned in an arcuate path across the entire cornea surface. The method ...

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    9. The short-term effects of aflibercept on the size of choroidal neovascularization lesion in treatment-resistant neovascular age-related macular degeneration as determined by spectral-domain optical coherence tomography

      The short-term effects of aflibercept on the size of choroidal neovascularization lesion in treatment-resistant neovascular age-related macular degeneration as determined by spectral-domain optical coherence tomography

      Background and Objectives To evaluate the changes in the size of choroidal neovascularization (CNV) lesion using spectral domain-optical coherence tomography (SD-OCT) in patients with treatment-resistant neovascular age-related macular degeneration (AMD) who were switched from ranibizumab to aflibercept. Materials and Methods In this prospective case-series, 33 eyes of 30 patients with treatment-resistant neovascular AMD were included. Treatment-resistant neovascular AMD was defined as choriodal neovascularization secondary to AMD determined by subretinal fluid and/or intraretinal fluid/cysts after more than 6 months of monthly ranibizumab therapy. Enrolled eyes were received intravitreal aflibercept injections at weeks 0, 4, and 8. Maximum area of ...

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    10. Macular Thickness Measurements with Frequency Domain-OCT for Quantification of Retinal Neural Loss and its Correlation with Cognitive Impairment in Alzheimerʼs Disease

      Macular Thickness Measurements with Frequency Domain-OCT for Quantification of Retinal Neural Loss and its Correlation with Cognitive Impairment in Alzheimerʼs Disease

      Purpose To evaluate the ability of frequency domain optical coherence tomography (fd-OCT) to estimate retinal neural loss in eyes with Alzheimer’s disease (AD). We also verified the existence of a correlation between AD-related cognitive impairment and macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements. Methods fd-OCT scans were obtained from 45 eyes of 24 patients with AD and 48 control eyes. Peripapillary RNFL, macular full-thickness and segmented inner macular thickness parameters were calculated. The inner macular parameters included macular retinal nerve fiber layer (mRNFL) thickness, ganglion cell layer (GCL) plus inner plexiform layer thickness (GCL+), and RNFL ...

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    11. En face swept-source optical coherence tomographic analysis of X-linked juvenile retinoschisis

      En face swept-source optical coherence tomographic analysis of X-linked juvenile retinoschisis

      Purpose To clarify the area of retinoschisis by X-linked juvenile retinoschisis (XLRS) using swept-source optical coherence tomography (SS-OCT) en face images. Observations We report two cases of XLRS in the same family. The patients presented with bilateral blurred vision. The posterior segment examination showed a spoked-wheel pattern in the macula. SS-OCT cross-sectional images revealed widespread retinal splitting at the level of the inner nuclear layer bilaterally. We diagnosed XLRS. To evaluate the area of retinoschisis, we obtained en face SS-OCT images, which clearly visualized the area of retinoschisis seen as a sunflower-like structure in the macula. Conclusion and Importance We ...

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    12. Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: Optical coherence tomography findings in major depression

      Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: Optical coherence tomography findings in major depression

      • OCT has been used in various neurodegenerative diseases to visualize the process of neurodegeneration. • We assessed 58 patients with major depression and 57 healthy controls in terms of optical coherence tomography. • Depressed patients were not diferent from the healthy controls with regard to OCT parameters. • Ganglion cell-inner plexiform layer and nasal retinal fiber layer were correlated with the duration of the latest depressive episode.

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    13. Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography

      Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography

      Purpose To investigate the influence of various risk factors on thinning of the lamina cribrosa (LC), as measured with swept-source optical coherence tomography (SS-OCT; Topcon). Methods This retrospective study comprised 150 eyes of 150 patients: 22 normal subjects, 28 preperimetric glaucoma (PPG) patients, and 100 open-angle glaucoma patients. Average LC thickness was determined in a 3 x 3 mm cube scan of the optic disc, over which a 4 x 4 grid of 16 points was superimposed (interpoint distance: 175 μm), centered on the circular Bruch’s membrane opening. The borders of the LC were defined as the visible limits ...

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    14. Essentials of OCT in Ocular Disease (Textbook)

      Essentials of OCT in Ocular Disease (Textbook)

      Written by the leading authorities in the field, Essentials of OCT in Ocular Disease is a core clinical reference on this important new technology used to examine the structure of the eye. It provides residents and practicing ophthalmologists with essential information on how to use OCT in various clinical scenarios and guidance on patient management. Chapters include coverage of recent innovative diagnostic applications as well as OCT-guided surgical procedures,including IOL position, DMEK, PDEK, GLUED IOL, and subtenon injection. Key Features: Edited by Amar Agarwal, a pioneer in OCT research, with chapters written by world-renowned experts in the use of ...

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    15. Haag-Streit UK to host Ophthalmic Ultrasound & OCT Course

      Haag-Streit UK to host Ophthalmic Ultrasound & OCT Course

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is delighted to confirm that it will be hosting an Ophthalmic Ultrasound & OCT Course on Monday 20th June, 2016. The course will be held at Crewe Hall in Cheshire and is aimed at those working with ophthalmic ultrasound in their daily practice and those using OCT in medical retina. The course will be beneficial for those with an interest in the emerging technology of Optical Coherence Tomography Angiography (OCT-A). The expert Faculty includes Tarek El-Khashab, Consultant Ophthalmologist & Lead for Ophthalmic Ultrasound services at Mid-Cheshire Hospitals NHS ...

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      Mentions: Haag-Streit
    16. Post-Doctoral Opening in Adaptive Optics at The University of Houston, College of Optometry

      Post-Doctoral Opening in Adaptive Optics at The University of Houston, College of Optometry

      Job Description: A postdoctoral position is available in Jason Marsack's laboratory at the University of Houston College of Optometry (UHCO). The successful applicant will be involved in the design, construction, alignment and operation of an adaptive optics system that allows for the presentation of visual stimuli and assessment of subjective visual performance. The system will be used to perform these psychophysical experiments under various levels of aberration compensation. The successful applicant will be an integral member of a team conducting a family of experiments characterizing the visual limits of individuals with highly aberrated ocular optics. UHCO ( http://www.opt ...

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    17. Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Importance Optical coherence tomographic angiography (OCTA) is a recently developed noninvasive imaging technique that can visualize the retinal and choroidal microvasculature without the injection of exogenous dyes. Objective To evaluate the potential clinical utility of OCTA using a prototype swept-source OCT (SS-OCT) device and compare it with fluorescein angiography (FA) for analysis of the retinal microvasculature in diabetic retinopathy. Design, Setting, and Participants Prospective, observational cross-sectional study conducted at a tertiary care academic retina practice from November 2013 through November 2014. A cohort of diabetic and normal control eyes were imaged with a prototype SS-OCT system. The stage of diabetic ...

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    18. Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into surgical microscopes to provide monoscopic viewing of OCT data through one microscope ocular. To take full advantage of our previously reported real-time volumetric microscope-integrated OCT (4D MIOCT) system, we describe a stereoscopic HUD which projects a stereo pair of OCT volume renderings into both oculars simultaneously. The stereoscopic HUD uses a novel optical design employing spatial multiplexing to project dual OCT volume renderings utilizing a single micro-display ...

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    19. Optical Coherence Tomography Angiography in a Patient with Optic Atrophy After Non-arteritic Anterior Ischaemic Optic Neuropathy

      Optical Coherence Tomography Angiography in a Patient with Optic Atrophy After Non-arteritic Anterior Ischaemic Optic Neuropathy

      A 75-year-old female noticed a lower visual field (VF) defect in the right eye. A diagnosis of non-arteritic anterior ischaemic optic neuropathy (NAION) was made. The lower VF defect in the right eye did not change after onset. Optical coherence tomography (OCT) angiograms on the disc and the macula showed decreased retinal perfusion in the upper retina of the right eye. Retinal nerve fibre layer loss and ganglion cell complex loss in the upper retina were also seen in the right eye. OCT angiography could non-invasively detect the decrease of the retinal perfusion due to NAION.

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    20. Targeted Screening of Macular Edema by Spectral Domain Optical Coherence Tomography for Progression of Diabetic Retinopathy

      Targeted Screening of Macular Edema by Spectral Domain Optical Coherence Tomography for Progression of Diabetic Retinopathy

      Background: Spectral domain optical coherence tomography (SD-OCT) is a highly sensitive, reliable, non invasive imaging tool. It is widely prevalent for application in diagnosis and management of various vitreoretinal diseases including diabetic retinopathy. This study aims to establish target screening of macular edema by SD-OCT for progression of diabetic retinopathy. Methods: One hundred and seventy seven consecutive cases of type 2 diabetes mellitus were divided into three groups: diabetes without retinopathy (No DR; n=59), non-proliferative diabetic retinopathy (NPDR; n=59), and proliferative diabetic retinopathy (PDR; n=59). Fifty nine healthy controls were included. Central subfield thickness (CST) and cube ...

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      Mentions: Sandeep Saxena
    21. Comparing Macular Thickness Measurements in Patients with Diabetic Macular Edema with the Optos Spectral OCT/SLO and Heidelberg Spectralis HRA + OC

      Comparing Macular Thickness Measurements in Patients with Diabetic Macular Edema with the Optos Spectral OCT/SLO and Heidelberg Spectralis HRA + OC

      The aim of this study was to compare measurements of macular thickness, obtained from patients with diabetic macular edema, using two spectral-domain optical coherence tomography (SD-OCT) devices. These were the Spectralis Heidelberg Retina Angiograph + Optical Coherence Tomography (HRA + OCT) (Heidelberg Engineering), which is often considered the gold-standard for OCT measurement, and the Spectral Optical Coherence Tomography/Scanning Laser Ophthalmoscopy (OCT/SLO) (Optos plc), which can additionally perform microperimetry, a useful measure of visual function. In this prospective observational study, each eye had SD-OCT performed with both devices on the same day by the same investigator. Mean retinal thickness was calculated ...

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    22. Depth-Resolved Full-Field Measurement of Corneal Deformation by Optical Coherence Tomography and Digital Volume Correlation

      Depth-Resolved Full-Field Measurement of Corneal Deformation by Optical Coherence Tomography and Digital Volume Correlation

      The study of vertebrate eye cornea is an interdisciplinary subject and the research on its mechanical properties has significant importance in ophthalmology. The measurement of depth-resolved 3D full-field deformation behaviour of cornea under changing intraocular pressure is a useful method to study the local corneal mechanical properties. In this work, optical coherence tomography was adopted to reconstruct the internal structure of a porcine cornea inflated from 15 to 18.75 mmHg (close to the physical porcine intraocular pressure) in the form of 3D image sequences. An effective method has been developed to correct the commonly seen refraction induced distortions in ...

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    23. The 24-2 Visual Field Test Misses Central Macular Damage Confirmed by the 10-2 Visual Field Test and Optical Coherence Tomography

      The 24-2 Visual Field Test Misses Central Macular Damage Confirmed by the 10-2 Visual Field Test and Optical Coherence Tomography

      Purpose : To determine the extent to which the 24-2 visual field (VF) misses macular damage confirmed with both 10-2 VF and optical coherence tomography (OCT) tests and to evaluate the patterns of damage missed. Methods : One hundred forty-one eyes of 141 glaucoma patients or suspects underwent 24-2 VF (mean deviation [MD] better than −6 dB), 10-2 VF, and OCT testing. Retinal nerve fiber layer (RNFL) and retinal ganglion cell plus inner plexiform (RGC+) probability plots were combined with 10-2 VF probability plots. Eyes were classified as “abnormal macula” if abnormal regions on both the 10-2 VF and OCT plots agreed ...

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    24. Correlation of Retinal Nerve Fiber Layer Thickness and Axial Length on Fourier Domain Optical Coherence Tomography

      Correlation of Retinal Nerve Fiber Layer Thickness and Axial Length on Fourier Domain Optical Coherence Tomography

      Introduction: The assessment of the peripapillary Retinal Nerve Fiber Layer (RNFL) thickness has been an important tool for evaluating and diagnosing glaucoma and its progression. Literature suggests that myopic eyes are at an increased risk for developing glaucoma. This study gives an insight into the relationship of RNFL thickness to the axial length in normal population. Aim: To correlate the RNFL thickness and the axial length in normal individuals with Fourier domain Optical Coherence Tomography (OCT). Materials and Methods: In the current study, 298 eyes of 149 normal individuals (10 years or older) with or without refractive error were recruited ...

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