1. Articles in category: Ophthalmology

    577-600 of 5899 « 1 2 ... 22 23 24 25 26 27 28 ... 244 245 246 »
    1. OCT determined macular thickness in diabetic retinopathy and relation to colour vision deficiency patterns

      OCT determined macular thickness in diabetic retinopathy and relation to colour vision deficiency patterns

      Background: Diabetic retinopathy is the most common cause of blindness in industrialised nations and the incidence of diabetes is expected to rise over the next 10 years. Early treatment of proliferative diabetic retinopathy and diabetic maculopathy improves visual outcome and with effective screening, blindness could be reduced. Patients suffering from diabetes mellitus show alterations in their colour perception. Colour vision testing provides a sensitive, non-invasive method to assess macular damage in diabetic retinopathy and any deterioration in colour vision often precedes changes in other clinical measures such as visual acuity and morphological changes. Optical coherence tomography (OCT) provides cross-sectional images ...

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    2. The Diagnostic Function of OCT in Diabetic Maculopathy

      The Diagnostic Function of OCT in Diabetic Maculopathy

      Diabetic maculopathy (DM) is one of the major causes of vision impairment in individuals with diabetes. The traditional approach to diagnosis of DM includes fundus ophthalmoscopy and fluorescein angiography. Although very useful clinically, these methods do not contribute much to the evaluation of retinal morphology and its thickness profile. That is why a new technique called optical coherence tomography (OCT) was utilized to perform cross-sectional imaging of the retina. It facilitates measuring the macular thickening, quantification of diabetic macular oedema, and detecting vitreoretinal traction. Thus, OCT may assist in patient selection with DM who can benefit from treatment, identify what ...

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    3. Visante Anterior Segment Optical Coherence Tomography Analysis of Morphologic Changes After Deep Sclerectomy With Intraoperative Mitomycin-C and No Implant Use

      Visante Anterior Segment Optical Coherence Tomography Analysis of Morphologic Changes After Deep Sclerectomy With Intraoperative Mitomycin-C and No Implant Use

      Purpose: To assess long-term intrascleral space maintenance after nonpenetrating deep sclerectomy (NPDS) without implant placement and with application of intraoperative mitomycin-C, using Visante anterior segment optical coherence tomography (AS-OCT). Patients and Methods: This cross-sectional, observational, case series study examined 47 eyes from 47 consecutive patients who had undergone NPDS 58.34±23.77 months earlier. All participants underwent a complete ophthalmologic examination. The presence of intrascleral space and its maximum anteroposterior and transverse lengths, maximum height, and volume were evaluated. The thickness of the trabeculo-Descemet membrane, presence and type of any subconjunctival filtering bleb, as well as scleral and suprachoroidal ...

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    4. Development of a Semi-Automatic Segmentation Method for Retinal OCT Images Tested in Patients with Diabetic Macular Edema

      Development of a Semi-Automatic Segmentation Method for Retinal OCT Images Tested in Patients with Diabetic Macular Edema

      Purpose To develop EdgeSelect, a semi-automatic method for the segmentation of retinal layers in spectral domain optical coherence tomography images, and to compare the segmentation results with a manual method. Methods SD-OCT (Heidelberg Spectralis) scans of 28 eyes (24 patients with diabetic macular edema and 4 normal subjects) were imported into a customized MATLAB application, and were manually segmented by three graders at the layers corresponding to the inner limiting membrane (ILM), the inner segment/ellipsoid interface (ISe), the retinal/retinal pigment epithelium interface (RPE), and the Bruch's membrane (BM). The scans were then segmented independently by the same ...

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    5. Optical Coherence Tomography Monitoring Strategies for A-VEGF Treated Age-Related Macular Degeneration: An Evidence-Based Analysis

      Optical Coherence Tomography Monitoring Strategies for A-VEGF Treated Age-Related Macular Degeneration: An Evidence-Based Analysis

      Background: The emergence of new anti-angiogenesis pharmacotherapies has dramatically altered the treatment of age-related macular degeneration (AMD) the leading cause of blindness in older adults. The monthly intraocular injection treatment regime, however, is extremely burdensome to ophthalmologists, patients and their families and repeated injections also have increased risks of potential complications or adverse events such as infection, injury or immune reactions. Although the pharmacokinetics of A-VEGF drugs are fairly well known, variation in an individuals’ AMD presentation and their pharmacodynamics or response to the drug has been shown to be extremely variable. Therefore treating everyone on the same fixed regime ...

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    6. SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES IN FELLOW EYES OF PATIENTS WITH IDIOPATHIC MACULAR HOLE

      SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES IN FELLOW EYES OF PATIENTS WITH IDIOPATHIC MACULAR HOLE

      Purpose: To describe the vitreomacular interface and foveal structural changes in fellow eyes of patients with idiopathic macular holes using spectral-domain optical coherence tomography (SD-OCT). Methods: Retrospective analysis of consecutive medical records and SD-OCT images of the fellow eyes of patients with macular hole was done. Changes of the vitreoretinal interface and foveal structures on SD-OCT scan of the 101 fellow eyes of 101 subjects with full-thickness macular hole were studied and compared with 101 eyes of 101 age-matched healthy subjects. Results: Sixty-four patients (57.65%) were female. Mean age at presentation was 60.44 ± 12.17 years. The best-corrected ...

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    7. SOLITARY CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM FEATURES BY HIGH-DEFINITION OPTICAL COHERENCE TOMOGRAPHY

      SOLITARY CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM FEATURES BY HIGH-DEFINITION OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To describe the features of solitary congenital hypertrophy of the retinal pigment epithelium (CHRPE) using high-definition optical coherence tomography (HD-OCT). Methods: This was a retrospective, observational, noncomparative case series including 16 consecutive patients with solitary CHRPE. We describe the clinical and OCT features of CHRPE using the 5 radial lines acquisition OCT protocol over the CHRPE and the retina next to the tumor. Results: The mean patient age was 54 years (median 57 years; range 8-76 years). The CHRPE lesion was outside the posterior pole in 14 of the patients (8 temporal, 3 superior, 2 nasal, and 1 inferior ...

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    8. Spectral Domain Optical Coherence Tomography Predictors of Visual Outcome in Diabetic Cystoid Macular Edema After Bevacizumab Injection

      Spectral Domain Optical Coherence Tomography Predictors of Visual Outcome in Diabetic Cystoid Macular Edema After Bevacizumab Injection

      PURPOSE:: To study prognostic spectral domain optical coherence tomography parameters in diabetic cystoid macular edema after anti-vascular endothelial growth factor therapy. METHODS:: Retrospective cohort study included 49 eyes with the new onset diabetic cystoid macular edema that had to have a macular spectral domain optical coherence tomography and fluorescein angiography at presentation. The baseline optical coherence tomography scans were analyzed for variables indicative of the extent of retinal involvement by the cystoid change and its location about the center. Univariate and multivariate analyses were performed comparing the optical coherence tomography findings between the two groups of eyes: the "No improvement ...

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    9. The Dose-Dependent Macular Thickness Changes Assessed By FD-OCT in Patients With Retinitis Pigmentosa Treated With Ciliary Neurotrophic Factor

      The Dose-Dependent Macular Thickness Changes Assessed By FD-OCT in Patients With Retinitis Pigmentosa Treated With Ciliary Neurotrophic Factor

      Purpose: To evaluate the effect of intravitreal ciliary neurotrophic factor (CNTF) implant on mean macular thickness (MMT) in eyes with retinitis pigmentosa using high-resolution Fourier domain optical coherence tomography imaging. Methods: A cohort of 8 patients (CNTF-3: n = 5; CNTF-4: n = 3) enrolled in Neurotech sponsored Phase 2 clinical trial underwent Fourier domain optical coherence tomography imaging. A >=3% change in MMT from baseline or fellow eye was considered as a measurable change. Results: Two patients enrolled in the CNTF-3 study received low-dose implant. At 18 months, a change in MMT from -4.47 [mu]m to 6 [mu]m ...

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    10. Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Purpose : To describe the findings of optical coherence tomography and clinical characteristics in patients of zonal outer retinopathy associated with punctuate inner choroidopathy. Method : Review of consecutive cases on fundus photographs, spectral domain ocular coherence tomography, fluorescein angiography, indocyanine green angiography, visual field, and electrophysiological studies of patients with punctate inner choroidopathy and associated zonal outer retinopathy. Results : This study involves 4 patients suffering visual field defect far beyond the area corresponding to punctate inner choroidopathy lesions. Findings in optical coherence tomography include attenuated signals of photoreceptor inner/outer segment areas corresponding to visual field defect, and increased choroidal thickness ...

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    11. Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography

      Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography

      Purpose: To analyze age-related morphological changes of the iridocorneal angle in normal subjects and glaucomatous cases, using anterior segment optical coherence tomography (AS-OCT). Methods: This study involved 58 eyes of 58 open-angle glaucoma cases and 72 eyes of 72 age-matched normal-open-angle control subjects. Iridocorneal angle structures in nasal and temporal regions and anterior chamber depth (ACD) were measured using AS-OCT. Axial length and refractive error were measured by use of an ocular biometer and auto refractor keratometer. Angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA), measured at 500 µm (TISA500) and 750 µm (TISA750) distant ...

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    12. Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Ocular Coherence Tomographic and Clinical Characteristics in Patients of Punctuate Inner Choroidopathy Associated with Zonal Outer Retinopathy

      Purpose : To describe the findings of optical coherence tomography and clinical characteristics in patients of zonal outer retinopathy associated with punctuate inner choroidopathy . Method : Review of consecutive cases on fundus photographs, spectral domain ocular coherence tomography, fluorescein angiography, indocyanine green angiography, visual field, and electrophysiological studies of patients with punctate inner choroidopathy and associated zonal outer retinopathy . Results : This study involves 4 patients suffering visual field defect far beyond the area corresponding to punctate inner choroidopathy lesions. Findings in optical coherence tomography include attenuated signals of photoreceptor inner / outer segment areas corresponding to visual field defect, and increased choroidal thickness ...

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    13. Glaucoma Diagnostic Accuracy of Machine Learning Classifiers Using Retinal Nerve Fiber Layer and Optic Nerve Data from SD-OCT

      Glaucoma Diagnostic Accuracy of Machine Learning Classifiers Using Retinal Nerve Fiber Layer and Optic Nerve Data from SD-OCT

      To investigate the diagnostic accuracy of machine learning classifiers (MLCs) using retinal nerve fiber layer (RNFL) and optic nerve (ON) parameters obtained with spectral domain optical coherence tomography (SD-OCT). Methods . Fifty-seven patients with early to moderate primary open angle glaucoma and 46 healthy patients were recruited. All 103 patients underwent a complete ophthalmological examination, achromatic standard automated perimetry, and imaging with SD-OCT. Receiver operating characteristic (ROC) curves were built for RNFL and ON parameters. Ten MLCs were tested. Areas under ROC curves (aROCs) obtained for each SD-OCT parameter and MLC were compared. Results . The mean age was years for healthy ...

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    14. Thickness Mapping of Eleven Retinal Layers in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      Thickness Mapping of Eleven Retinal Layers in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      Purpose. This study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Methods. Mean regional retinal thickness of 11 retinal layers were obtained by automatic three-dimensional diffusion-map-based method in 112 normal eyes of 76 Iranian subjects. Results. The thickness map of central foveal area in layer 1, 3, and 4 displayed the minimum thickness (P<0.005 for all). Maximum thickness was observed in nasal to the fovea of layer 1 (P<0.001) and in a circular pattern in ...

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    15. Progress on Developing Adaptive Optics–Optical Coherence Tomography for In Vivo Retinal Imaging: Monitoring and Correction of Eye Motion Artifacts

      Progress on Developing Adaptive Optics–Optical Coherence Tomography for In Vivo Retinal Imaging: Monitoring and Correction of Eye Motion Artifacts

      Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the human retina. Here, we present a short review of progress on developing AO-OCT instruments. Despite significant progress in imaging speed and resolution, eye movements present during acquisition of a retinal image with OCT introduce motion artifacts into the image, complicating analysis and registration. This effect is especially pronounced in high-resolution datasets acquired with AO-OCT instruments. Several retinal tracking ...

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    16. A novel view of punctate inner choroidopathy: Characterizing the serial changes by high resolution spectrum-domain optical coherence tomography

      A novel view of punctate inner choroidopathy: Characterizing the serial changes by high resolution spectrum-domain optical coherence tomography

      Purpose We report a case of punctate inner choroidopathy (PIC) treated with oral prednisolone and intravitreous bevacizumab injection (IVB). Methods One case was studied and followed for 5 months by serial spectrum-domain optical coherence tomography (SD-OCT). Results At the early active phase of PIC, SD-OCT showed dome-shaped retinal pigment epithelium (RPE) elevation with underlying intact Bruch's membrane (BM), overlying photoreceptor inner/outer segment junction (PRJ) disappearance, and homogenous hyperreflective sub-RPE signals. After oral prednisolone and IVB, SD-OCT showed resolution of RPE changes with overlying intact PRJ. Further, the localized outer retinal layers were found to gradually move outward. Conclusions ...

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    17. Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror

      Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror

      We developed an ultrahigh speed, handheld swept source optical coherence tomography (SS-OCT) ophthalmic instrument using a 2D MEMS mirror. A vertical cavity surface-emitting laser (VCSEL) operating at 1060 nm center wavelength yielded a 350 kHz axial scan rate and 10 µm axial resolution in tissue. The long coherence length of the VCSEL enabled a 3.08 mm imaging range with minimal sensitivity roll-off in tissue. Two different designs with identical optical components were tested to evaluate handheld OCT ergonomics. An iris camera aided in alignment of the OCT beam through the pupil and a manual fixation light selected the imaging ...

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    18. Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode

      Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode

      New hand-held optical device to catch early signs of retinal disease WASHINGTON, Dec. 20, 2013—A new optical device puts the power to detect eye disease in the palm of a hand. The tool—about the size of a hand-held video camera—scans a patient’s entire retina in seconds and could aid primary care physicians in the early detection of a host of retinal diseases including diabetic retinopathy, glaucoma and macular degeneration. Researchers at the Massachusetts Institute of Technology (MIT) describe their new ophthalmic-screening instrument in a paper published today in the open-access journal Biomedical Optics Express , published by ...

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    19. Is Handheld Optical Coherence Tomography Reliable in Infants and Young Children With and Without Nystagmus?

      Is Handheld Optical Coherence Tomography Reliable in Infants and Young Children With and Without Nystagmus?

      Purpose. To evaluate the reliability of the spectral domain handheld OCT (HH-OCT) in assessing foveal morphology in children with and without nystagmus. Methods. Forty-nine subjects with nystagmus (mean age 43.83 months; range, 1–82 months) and 48 controls (mean age 43.02 months; range, 0 to 83 months) were recruited and scanned using HH-OCT. A minimum of two separate volumetric scans on the same examination day of the fovea were obtained. The images were imported into ImageJ software where manual retinal layer segmentation of the central foveal B-scan was performed. Agreement between scans was assessed by determining the intraclass ...

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    20. In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      Purpose. The lamina cribrosa (LC) is a prime location of glaucomatous damage. The purpose of this study was to compare LC 3-dimensional micro-architecture between healthy and glaucomatous eyes in vivo by using optical coherence tomography (OCT). Methods. Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47 subjects were scanned in a 3.5 × 3.5 × 3.64-mm volume (400 × 400 × 896 pixels) at the optic nerve head by using swept-source OCT. The LC micro-architecture parameters were measured on the visible LC by an automated segmentation algorithm. The LC parameters were compared to diagnosis and visual field mean deviation (VF MD ...

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    21. Ophthalmology, 4th Edition (Textbook)

      Ophthalmology, 4th Edition (Textbook)

      Get the quick answers you need on every aspect of clinical ophthalmology and apply them in your day-to-day practice . The latest edition of Ophthalmology by Drs. Yanoff and Duker presents practical, expert, concise guidance on nearly every ophthalmic condition and procedure, equipping you to efficiently overcome whatever clinical challenges you may face.

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    22. Choriocapillaris and Choroidal Microvasculature Imaging with Ultrahigh Speed OCT Angiography

      Choriocapillaris and Choroidal Microvasculature Imaging with Ultrahigh Speed OCT Angiography

      We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a 400 kHz A-scan rate is developed for three-dimensional ultrahigh speed imaging of the posterior eye. OCT angiography is used to image three-dimensional vascular structure without the need for exogenous fluorophores by detecting erythrocyte motion contrast between OCT intensity cross-sectional images acquired rapidly and repeatedly from the same location on the retina. En face OCT angiograms of the choriocapillaris and choroidal vasculature are visualized by acquiring cross-sectional OCT angiograms volumetrically ...

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    23. Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma

      Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma

      Purpose To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomography (SD-OCT) in glaucoma. Design Cross-sectional study. Methods 252 eyes of 183 control subjects (mean MD: -1.84 dB) and 207 eyes of 159 glaucoma patients (mean MD: -7.31 dB) underwent ONH, RNFL and GCC scanning with SD-OCT. Scan quality of SD-OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD-OCT was evaluated by receiver operating characteristic (ROC ...

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