1. Articles in category: Ophthalmology

    577-600 of 8253 « 1 2 ... 22 23 24 25 26 27 28 ... 342 343 344 »
    1. Evaluating Efficacy of Aflibercept in Refractory Exudative Age-Related Macular Degeneration With OCT Segmentation Volumetric Analysis

      Evaluating Efficacy of Aflibercept in Refractory Exudative Age-Related Macular Degeneration With OCT Segmentation Volumetric Analysis

      BACKGROUND AND OBJECTIVE: To use automated segmentation software to analyze spectral-domain optical coherence tomography (SD-OCT) scans and evaluate the effectiveness of aflibercept (Eylea; Regeneron, Tarrytown, NY) in the treatment of patients with exudative age-related macular degeneration (AMD) refractory to other treatments. PATIENTS AND METHODS: Retrospective chart review of 16 patients refractory to bevacizumab (Avastin; Genentech, South San Francisco, CA)/ranibizumab (Lucentis; Genentech, San Francisco, CA) treatment was conducted. Visual acuity, central foveal thickness (CFT), maximum fluid height, pigment epithelial detachment (PED) volume, sub-retinal fluid (SRF) volume, fluid-free time interval, and adverse effects were evaluated. Automated segmentation analysis was used to ...

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    2. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany ...

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    3. Is Optical Coherence Tomography a Useful Tool to Objectively Detect Actual Posterior Vitreous Adhesion Status?

      Is Optical Coherence Tomography a Useful Tool to Objectively Detect Actual Posterior Vitreous Adhesion Status?

      Purpose . To objectively detect true posterior vitreous cortex (PVC) adhesion status using a commercially available swept-source OCT device (DRI OCT-1, Atlantis © ). Material and Methods . Case report, review of the literature, and methodical discussion of concepts to improve OCT-guided PVC imaging. Results . Standard OCT imaging misdiagnosed PVC adhesion status as totally detached in this case report when using a horizontal 6 mm scan only. Contrariwise imaging the same eye with a 12 mm horizontal scan, partial posterior vitreous detachment (PVD) and the presence of a bursa premacularis were clearly discernible. Besides a broader scan, specific scan patterns, highest resolution, and contrast ...

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    4. Evaluation of Tear Meniscus Dynamics Using Anterior Segment Swept-Source Optical Coherence Tomography After Topical Solution Instillation for Dry Eye

      Evaluation of Tear Meniscus Dynamics Using Anterior Segment Swept-Source Optical Coherence Tomography After Topical Solution Instillation for Dry Eye

      Purpose: To investigate tear meniscus dynamics using anterior segment swept-source optical coherence tomography (SS-OCT) after the instillation of topical solutions for dry eye. Design: Prospective, observational, cross-sectional study. Methods: Thirty-six healthy subjects (28 men and 8 women; mean age, 34.4 +/- 6.7 years) were enrolled in this study. The lower tear meniscus height, tear meniscus area, and tear meniscus volume were assessed using anterior SS-OCT. After baseline measurements, 40 [mu]L of 0.1% sodium hyaluronate, 0.3% sodium hyaluronate, 3% diquafosol ophthalmic solution, or 2% rebamipide ophthalmic solution was instilled in one eye of 10 subjects each, whereas ...

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    5. OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS OF MACULAR EDEMA AND HARD EXUDATES AND THEIR ASSOCIATION WITH LIPID SERUM LEVELS IN TYPE 2 DIABETES

      OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS OF MACULAR EDEMA AND HARD EXUDATES AND THEIR ASSOCIATION WITH LIPID SERUM LEVELS IN TYPE 2 DIABETES

      Purpose: To determine whether hyperreflective foci (HF) and macular thickness on spectral domain ocular coherence tomography are associated with lipid levels in patients with Type 2 diabetes. Methods: Two hundred and thirty-eight participants from four sites had fundus photographs and spectral domain ocular coherence tomography images graded for hard exudates and HF, respectively. Regression models were used to determine the association between serum lipid levels and 1) presence of HF and hard exudates and 2) central subfield macular thickness, central subfield macular volume, and total macular volume. Results: All patients with hard exudates on fundus photographs had corresponding HF on ...

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    6. Anterior segment optical coherence tomography–guided management of capsular block syndrome following penetrating keratoplasty

      Anterior segment optical coherence tomography–guided management of capsular block syndrome following penetrating keratoplasty

      Capsular block syndrome (CBS) is a recognized complication after cataract surgery. It is caused by fluid accumulation in a closed chamber inside the capsular bag due to the nucleus or intraocular lens (IOL) optic occluding the capsule opening created by the continuous curvilinear capsulorhexis.1,2 We present a case of CBS following penetrating keratoplasty (PKP) with cataract extraction and IOL implantation (triple procedure) that was diagnosed using anterior segment optical coherence tomography (AS-OCT).

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    7. Association of iris surface features with iris parameters assessed by swept-source optical coherence tomography in Asian eyes

      Association of iris surface features with iris parameters assessed by swept-source optical coherence tomography in Asian eyes

      Background/aims To characterise the association of iris surface features (crypts, furrows and colour) with iris volume and curvature assessed by swept-source optical coherence tomography (SSOCT) in Asian eyes. Methods Iris crypts (by number and size) and furrows (by number and circumferential extent) were graded from iris photographs. Iris colour was measured by a customised algorithm written on MATLAB (MathWorks, Natick, Massachusetts, USA). The iris was imaged by SSOCT (SS-1000, CASIA, Tomey, Nagoya, Japan). The associations of surface features with iris parameters were analysed using a generalised estimating equation. Results A total of 1704 subjects (3297 eyes) were included in ...

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    8. Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic Antimalarials

      Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic Antimalarials

      Maculopathy induced by retinal toxicity of synthetic antimalarials is to be screened at the sub-clinical stage. Indeed, when the first visual symptoms appear, macular damage is already irreversible and the clinical picture may even continue to deteriorate for several years after the end of synthetic antimalarial use. In opposition, the early termination of hydroxychloroquine in patients showing recent alterations on the multifocal electroretinogram (nfERG) allowed he reversibility of toxic damage over a six month period. It is therefore critical to detect early retinal anatomic changes during retinotoxicity screening before the occurrence of irreversible anatomical and functional consequences. The usual patient ...

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    9. Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes

      Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes

      Purpose Ruling out glaucoma in myopic eyes often poses a diagnostic challenge because of atypical optic disc morphology and visual field defects that can mimic glaucoma. We determined whether neuroretinal rim assessment based on Bruch's membrane opening (BMO), rather than conventional optic disc margin (DM)-based assessment or retinal nerve fiber layer (RNFL) thickness, yielded higher diagnostic accuracy in myopic patients with glaucoma. Design Case-control, cross-sectional study. Participants Myopic patients with glaucoma (n = 56) and myopic normal controls (n = 74). Methods Myopic subjects with refraction error greater than −2 diopters (D) (spherical equivalent) and typical myopic optic disc morphology ...

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    10. In Vivo 3-Dimensional Strain Mapping of the Optic Nerve Head Following Intraocular Pressure Lowering by Trabeculectomy

      In Vivo 3-Dimensional Strain Mapping of the Optic Nerve Head Following Intraocular Pressure Lowering by Trabeculectomy

      Purpose To map the 3-dimensional (3D) strain of the optic nerve head (ONH) in vivo after intraocular pressure (IOP) lowering by trabeculectomy (TE) and to establish associations between ONH strain and retinal sensitivity. Design Observational case series. Participants Nine patients with primary open-angle glaucoma (POAG) and 3 normal controls. Methods The ONHs of 9 subjects with POAG (pre-TE IOP: 25.3±13.9 mmHg; post-TE IOP: 11.8±8.6 mmHg) were imaged (1 eye per subject) using optical coherence tomography (OCT) (Heidelberg Spectralis, Heidelberg Engineering GmbH, Heidelberg, Germany) before (<21 days) and after (<50 days) TE. The imaging protocol ...

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    11. Ultra-Widefield Steering-Based Spectral-Domain Optical Coherence Tomography Imaging of the Retinal Periphery

      Ultra-Widefield Steering-Based Spectral-Domain Optical Coherence Tomography Imaging of the Retinal Periphery

      Purpose To describe the spectral-domain optical coherence tomography (SD OCT) features of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the retinal periphery. Design Observational study. Participants A total of 68 patients (68 eyes) with 19 peripheral retinal features. Main Outcome Measures Spectral-domain OCT–based structural features. Methods Nineteen peripheral retinal features, including vortex vein, congenital hypertrophy of the retinal pigment epithelium, pars plana, ora serrata pearl, typical cystoid degeneration (TCD), cystic retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rhegmatogenous retinal detachment, typical degenerative senile retinoschisis, peripheral laser coagulation scars, ora tooth ...

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    12. Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives NIH Grant  for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives a 2016 NIH Grant for $691,728 for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care. The principal investigator is Cynthia Toth. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that may impact vision in vulnerable preterm neonates for a lifetime. Clinical care of infants with ROP decreases the likelihood of blindness, but abnormal vision is common, especially in those with disease severe enough to require treatment. Because it has ...

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    13. High-resolution Imaging of Tear Film Thickness in Contact Lenses Wearers With Optical Coherence Tomography (OCT). A Pilot Study

      High-resolution Imaging of Tear Film Thickness in Contact Lenses Wearers With Optical Coherence Tomography (OCT). A Pilot Study

      A refractive error is the most common reason for reduced visual acuity. Myopia, hyperopia, astigmatism and presbyopia belong to the four basic refractive errors and, unfortunately, cannot be prevented. There are different tools to correct them, like spectacles, contact lenses, and refractive surgery. Many different contact lenses are available, the two large groups create rigid contact lenses and soft contact lenses. It is a common knowledge that the presence of a contact lens in the eye divides the tear film into the prelens and postlens tear film layers. In the present study we want to investigate the variability and reproducibility ...

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    14. Automated detection of inflammatory cells in whole anterior chamber of a uveitis mouse from swept-source optical coherence tomography images

      Automated detection of inflammatory cells in whole anterior chamber of a uveitis mouse from swept-source optical coherence tomography images

      Cell grading in a rodent anterior chamber is essential for anterior inflammation evaluation in preclinical vision research. This paper describes a computerized method for detection and counting of the anterior chamber cells from swept-source optical coherence tomography (SS-OCT) images of a experimental rodent model of uveitis. The volumetric anterior segment OCT data is obtained from 100 kHz SS-OCT imaging of mouse eye in vivo. For the OCT cross-sections, each OCT structural image is de-speckled and binarized. After removal of cornea, iris, and crystalline lens structures connected to the binary image border, an area thresholding is then employed for each labeled ...

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    15. Simulation of broad spectral bandwidth emitters at 1060 nm for retinal optical coherence tomography

      Simulation of broad spectral bandwidth emitters at 1060 nm for retinal optical coherence tomography

      The simulation of broad spectral bandwidth light sources (semiconductor optical amplifiers (SOA) and superluminescent diodes (SLD)) for application in ophthalmic optical coherence tomography is reported. The device requirements and origin of key device parameters are outlined, and a range of single and double InGaAs/GaAs quantum well (QW) active elements are simulated with a view to application in different OCT embodiments. We confirm that utilising higher order optical transitions is beneficial for single QW SOAs, but may introduce deleterious spectral modulation in SLDs. We show how an addition QW may be introduced to eliminate this spectral modulation, but that this ...

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    16. Computational adaptive optics of the human retina

      Computational adaptive optics of the human retina

      It is well known that patient-specific ocular aberrations limit imaging resolution in the human retina. Previously, hardware adaptive optics (HAO) has been employed to measure and correct these aberrations to acquire high-resolution images of various retinal structures. While the resulting aberration-corrected images are of great clinical importance, clinical use of HAO has not been widespread due to the cost and complexity of these systems. We present a technique termed computational adaptive optics (CAO) for aberration correction in the living human retina without the use of hardware adaptive optics components. In CAO, complex interferometric data acquired using optical coherence tomography (OCT ...

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    17. Eye motion corrected OCT imaging with Lissajous scan pattern

      Eye motion corrected OCT imaging with Lissajous scan pattern

      Ophthalmic optical coherence tomography (OCT) is a powerful tool which provides high resolution three dimensional (3D) volumetric image of human retina. However, the measurement data of OCT suffer motion artifact due to the involuntary eye motion during data acquisition. To eliminate this motion artifact and provide the true shape of retinal image, an eye motion corrected OCT imaging method based on Lissajous scan pattern is proposed in this paper. In this approach, we adopted Lissajous scan pattern for 3D-OCT imaging and developed motion correction algorithm. To verify the effectiveness of this method, we compare our method with single raster scan ...

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    18. Choroidal vasculature characteristics based choroid segmentation for enhanced depth imaging optical coherence tomography image

      Choroidal vasculature characteristics based choroid segmentation for enhanced depth imaging optical coherence tomography image

      Purpose: In clinical research, it is important to measure choroidal thickness when eyes are affected by various diseases. The main purpose is to automatically segment choroid for enhanced depth imaging optical coherence tomography (EDI-OCT) images with five B-scans averaging. Methods: The authors present an automated choroid segmentation method based on choroidal vasculature characteristics for EDI-OCT images with five B-scans averaging. By considering the large vascular of the Haller’s layer neighbor with the choroid-sclera junction (CSJ), the authors measured the intensity ascending distance and a maximum intensity image in the axial direction from a smoothed and normalized EDI-OCT image. Then ...

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    19. ARVO Special Interest Group (SIG) on:Optical Coherence Tomography Angiography of the Eye, May 4th 2015 Seattle.

      ARVO Special Interest Group (SIG) on:Optical Coherence Tomography Angiography of the Eye, May 4th 2015 Seattle.

      ARVO May 1-5, 2016, Seattle, Washington, USA Association for Research in Vision and Ophthalmology (ARVO) Special Interest Group (SIG) Title: Optical Coherence Tomography Angiography of the Eye – David Huang, Philip Rosenfeld, James Fujimoto, Yoshiaki Yasuno, Srinivas Sadda, Richard Rosen, Bruno Lumbroso, Session Number: 455,Session Date/Start Time: May 4, 2016 from 1:00 PM to 2:30 PM Room: Tahoma 1/2

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    20. Ophthalmic analysis apparatus and ophthalmic analysis program

      Ophthalmic analysis apparatus and ophthalmic analysis program

      There is provided an ophthalmic analysis apparatus configured to acquire an analysis result of a tomographic image of a subject eye which is acquired by using optical coherence tomography (OCT), and to output the analysis result. The apparatus functions as a display control unit configured to control a display unit to display a two-dimensional image based on an OCT tomographic image; an analysis region setting unit configured to set multiple analysis regions on the two-dimensional image displayed on the display unit by the display control unit; and an output control unit configured to acquire an analysis result in the multiple ...

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      Mentions: Nidek
    21. Three-dimensional retina image generator

      Three-dimensional retina image generator

      Provided is a three-dimensional retina image generator that can detect, in a precise manner, the scanning position displacement during scanning of the retina with a simple configuration and, as a result, and can obtain a high-quality retinal image with a reduced influence of speckle noise therein. In order to detect the movement of retina R, the three-dimensional retina image generator has: second light source unit 210 that outputs a line beam to be imaged on retina R; positional displacement detector 220 that detects the line beam reflected from retina R and that detects the "displacement" of the scanning position during ...

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      Mentions: Roy de Kinkelder
    22. Foveal haemorrhage from makeshift 'Lightsaber: funduscopy and optical coherence tomography findings

      Foveal haemorrhage from makeshift 'Lightsaber: funduscopy and optical coherence tomography findings

      A 15-year-old boy presented after being attacked by a ‘Lightsaber’ wielded by his friend. The device in question was a blue laser pointer (450 nm 8000 mW) reflected by his friend off a mirror—the beam caught the patient in the left eye for a mere 1 or 2 s. His vision dropped immediately and he presented the next day with a macular haemorrhage (figure 1) and a vision of 6/60. We treated via observation

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    23. Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography

      Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive method for retinal imaging. In this work, we present an in vivo human retinal microvascular network measurement by an intensity-based Doppler variance (IBDV) based on sweptsource OCT. In addition, an automatic three-dimensional (3-D) segmentation method was used for segmenting intraretinal layers. The microvascular networks were divided into six layers by visualizing of each individual layer with enhanced imaging contrast. This method has potential for earlier diagnosis and precise monitoring in retinal vascular diseases.

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    24. Predicting macular hole closure with ocriplasmin based on spectral domain optical coherence tomography

      Predicting macular hole closure with ocriplasmin based on spectral domain optical coherence tomography

      Purpose To assess the preoperative features of patients with idiopathic macular hole (IMH) and vitreomacular adhesion (VMA) treated with ocriplasmin (OCP) that can predict successful closure. Method Data were prospectively collected on all patients with IMH treated with OCP in three British ophthalmic centres. Several preoperative variables were recorded including the IMH base diameter (BD), minimum linear diameter (MLD), and VMA width measured on spectral domain optical coherence tomography. Several other IMH indices were derived including a ‘width factor’, defined as the BD minus the MLD in μm. The occurrence of VMA release and hole closure were used as the ...

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