1. Optical Coherence Tomography News

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    1. Feature Of The Week 07/22/2019: Tsinghua University Demonstrates A “Sparse Sampled” Smart CCD Camera for Compressed Sensing Optical Coherence Tomography.

      Feature Of The Week 07/22/2019: Tsinghua University Demonstrates A “Sparse Sampled” Smart CCD Camera for Compressed Sensing Optical Coherence Tomography.

      Optical coherence tomography (OCT) is a promising imaging technique in medicine and biology, which allows for obtaining high-resolution, cross-sectional images of biological tissues. In the past decade, the imaging speed of OCT is consistently increasing, and currently OCT can acquire three-dimensional (3D) images in real time with imaging speed up to 10-MHz A-scan rate. With such a high imaging rate, OCT system has to acquire a large amount of data, which is too massive for data transmission and storage. Compressed sensing (CS) technique is a powerful method to solve this problem. It exploits the sparsity property of the signal and ...

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    2. Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex

      Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex

      Massachusetts General Hospital Receives a 2019 NIH Grant for $463,473 for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex. The principal investigator is Anastasia Yendiki. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The objective of the proposed research is to map the organization of human white matter (WM) with cutting-edge ex vivo imaging technologies. This work will produce microscopic-level information on several long-range WM projections, as well as a more targeted mapping of circuits that serve the prefrontal cortex (PFC). These circuits are of particular interest in ...

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    3. Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives a 2019 NIH Grant for $300,000 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy ...

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    4. Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT

      Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT

      Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable Vertical Cavity Surface Emitting Lasers for Low-Cost Ophthalmic Swept Source Optical Coherence Tomography. The principal investigator is Christopher Burgner. The program began in 2012 and ends in 2020. Below is a summary of the proposed work. The ultimate goal of this effort is to bring advanced ophthalmic swept source optical coherence tomography (SS-OCT) imaging to low cost broadly accessible environments. SS-OCT is a powerful non-invasive diagnostic imaging modality, and an increasingly valuable tool in the early detection and monitoring of a number ...

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    5. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives a 2019 NIH Grant for $299,221 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...

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    6. 7th International Meeting on OCT Angiography and Advances in Imaging will be organized by Bruno Lumbroso M.D. in Rome December 13 and 14, 2019

      7th International Meeting on OCT Angiography and Advances in Imaging will be organized by Bruno Lumbroso M.D. in Rome December 13 and 14, 2019

      The 7 th International Meeting on OCT Angiography and Advances in Imaging will be organized by Bruno Lumbroso M.D. in Rome December 13 and 14, 2019. The meeting will present 75 sessions and 330 papers on clinical scientific and technological topics of OCT, OCT Angiography and other ocular imaging techniques, vascular anatomy and physiology. Latest progresses in OCT, OCT angiography, Wide angle retinography, Artificial Intelligence in Ocular Imaging will be underlined. The role of ocular circulation in chorio capillaris, choroid, retina, optic nerve will be given specific consideration. Location Hotel ERGIFE, Rome Italy Date Friday December 13 and Saturday ...

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      Mentions: Bruno Lumbroso
    7. Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests

      Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests

      Notal Vision, Inc., a company focused on advancing eye care with precision medicine by extending disease management from the clinic to the home, celebrates the completion of six million patient tests performed with ForeseeHome, the first FDA-cleared home-monitoring device for patients with intermediate dry Age-related Macular Degeneration (AMD) at risk for developing wet AMD. ForeseeHome uses a patented technology, Preferential Hyperacuity Perimetry® (PHP), that can identify minute changes in the central 14 degrees of visual field before the patient has any visual symptoms. During the test, which takes about three minutes, the central macula is evaluated for changes in metamorphopsia ...

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      Mentions: Notal Vision
    8. MGH Receives NIH Grant for Quantitative Biomechanics Imaging

      MGH Receives NIH Grant for Quantitative Biomechanics Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $340,916 for Quantitative Biomechanics Imaging. The principal investigator is Seok-Hyun Andy Yun. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. TRD 1 The proposed research in TRD Project 1 is to develop novel optical coherence tomography (OCT)-based techniques and tools for measuring the mechanical properties and parameters as well as acoustic transduction in tissues. The focus on tissue biomechanics responds to the emerging opportunity to harness OCT's unique capabilities to obtain quantitative maps of tissue vibration, deformation, strain, and ...

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    9. MGH Receives NIH Grant for: Percutaneous and Interstitial Imaging

      MGH Receives NIH Grant for: Percutaneous and Interstitial Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $317,085 for TRD23: Percutaneous and Interstitial Imaging. The principal investigator is Martin Villiger. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. TRD 3 The overall goal of TRD 3 is to enable advanced OCT imaging, with high resolution and functional and dynamic contrast, inside the living body, through narrow diameter, rotational probes. Instruments and algorithms will be developed that overcome fundamental barriers, intrinsic to flexible, rotational fiber-optic probes, that have previously compromised image quality and prohibited the integration of functional and ...

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    10. MGH Receives NIH Grant for TRD: Functional Imaging

      MGH Receives  NIH Grant  for TRD: Functional Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $338,551 for TRD: Functional Imaging. The principal investigator is Benjamin Vakoc. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. TRD 2 TRD project 2 will develop novel optical coherence tomography (OCT) technologies to address unmet needs in the functional imaging of tissue. Specific Aim #1 addresses the need for high-speed and high- resolution angiographic imaging systems for preclinical research. A new high-speed optical architecture for high-resolution optical coherence microscopy (OCM) will be constructed that is 100 times faster than existing OCM ...

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    11. MGH Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      MGH Receives  NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2019 NIH Grant for $749,999 for the Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource ...

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    12. UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT for In-vivo identification of Bacterial Otitis Media

      UIUC Receives NIH Grant for Integration of Raman Spectroscopy and OCT  for In-vivo identification of Bacterial Otitis Media

      University of Illinois at Urbana Champaign Receives a 2019 NIH Grant for $648,154 for Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-vivo identification of Bacterial Otitis Media. The principal investigator is Stephen Boppart. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Otitis media (middle ear infection) is a highly prevalent disease, especially in young children. It has been documented that more than 75% of children will have at least one episode of otitis media (OM) by age 3, and many children will have recurrent or chronic OM ...

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    13. Senior Scientist on Topcon Milpitas California

      Senior Scientist on Topcon Milpitas California

      Overview Topcon is a comprehensive ophthalmic device manufacturer within the worldwide ophthalmic community. It introduced the world’s first commercial back-of-the-eye spectral domain (SD) and swept source (SS) optical coherence tomography (OCT) systems, which have driven innovation in eye-care. More recently, Topcon Healthcare Solutions started to enhance not only its hardware but also its software solutions. To become the leader in diagnostic software, Topcon has developed a new strategic division whose primary objective is to create world-class software solutions for the eye-care industry and beyond. Our products enable the collection and visualization of a wide range of imaging and clinical ...

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    14. International Ocular Circulation Society Inaugural Meeting, August 10, 2019 Portland Oregon

      International Ocular Circulation Society Inaugural Meeting, August 10, 2019 Portland Oregon

      The International Ocular Circulation Society (IOCS) was co-founded by a group of leading researchers in America, Asia, and Europe in 2018. The inaugural meeting of the new Society will be hosted by David Huang, M.D. and Yali Jia, Ph.D. of the Casey Eye Institute in Portland Oregon on August 10, 2019. The meeting will present 28 papers and 35 posters on technologies on the topics of imaging and measurement of ocular blood flow and oxygen metabolism, vascular anatomy and physiology, and the roles of ocular circulation in retina, optic nerve, neurological, and systemic diseases. The Oregon Health & Science ...

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    15. Veterans Affairs Medical Center in San Francisco Receives a 2019 NIH Grant for Collateral Flow and Stroke Outcome

      Veterans Affairs Medical Center in San Francisco Receives a 2019 NIH Grant for Collateral Flow and Stroke Outcome

      Veterans Affairs Medical Center in San Francisco Receives a 2019 NIH Grant for Collateral Flow and Stroke Outcome. The principal investigator is Jialing Liu. . Below is a summary of the proposed work. Collateral status is an independent predictor of stroke outcome, as well as response to thrombolytic therapies in patients with ischemic stroke. Genetic factors contribute to the extent and development of native collaterals, whereas patients with metabolic syndromes are associated with poor collateral status during acute ischemic stroke. Diabetes increases the risk of stroke and exacerbates ischemic brain damage, although the impact of diabetes on collateral dynamics remains to ...

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    16. Baylor College of Medicine Receives NIH Grant for Biomechanics of Early Cardiogenesis

      Baylor College of Medicine Receives NIH Grant for Biomechanics of Early Cardiogenesis

      Baylor College of Medicine Receives a 2019 NIH Grant for $554,542 for Biomechanics of Early Cardiogenesis. The principal investigator is Irina Larina. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Human congenital heart defects (CHD) are very common, occurring in nearly 1% of live births. Moreover, cardiovascular (CV) failures are the leading cause of birth defect- related deaths in infants. It is well established that biomechanical stimuli are important regulators of CV development. Thus, defining how mechanical factors are integrated with genetic pathways to coordinate mammalian heart tube function and ...

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    17. University of Washington Receives NIH Grant for Biomechanics of Neural Tube Development Using Brillouin-OCT Multimodality

      University of Washington Receives NIH Grant for Biomechanics of Neural Tube Development Using Brillouin-OCT Multimodality

      University of Washington Receives a 2019 NIH Grant for $663,429 for Biomechanics of Neural Tube Development Using Brillouin-OCT Multimodality. The principal investigator is Kirill Larin. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. The objective of this proposal is to develop a non-contact, all-optical imaging technology to map elastic moduli and forces involved in critical aspects of embryonic development with high 3D resolution. The proposed technology is based on combined Brillouin spectroscopy and Optical Coherence Tomography (OCT), which will be used to gain fundamental understanding of biomechanical factors involved during ...

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    18. Case Western Reserve University Receives NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives a 2019 NIH Grant for $493,857 for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects. The principal investigator is Michael Jenkins. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Congenital heart defects (CHDs) are one of the most common and devastating birth defects, afflicting 32,000 babies born in the United States each year, and over 1 million Americans alive today. Altered hemodynamics during development has been shown to be a contributing factor to CHDs, regardless of whether ...

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    19. Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives a 2019 NIH Grant for $499,978 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system suitable for diagnostic retinal imaging at the point of care. The target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systems ...

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    20. Avinger Enrolls First 50 Patients in INSIGHT Clinical Trial

      Avinger Enrolls First 50 Patients in INSIGHT Clinical Trial

      Avinger, Inc. (NASDAQ: AVGR), a commercial-stage medical device company marketing the first-ever image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the 50 th patient enrolled in its INSIGHT clinical trial. The INSIGHT trial is a prospective, global, single arm, multi-center study to evaluate the safety and effectiveness of the Pantheris ® Lumivascular atherectomy system for treating in-stent restenosis (ISR) in lower extremity arteries. Dr. Jaafer Golzar, Avinger’s Chief Medical Officer and a highly experienced interventionalist, noted, “We are pleased to have the first 50 cases completed as part of our INSIGHT IDE study. Early ...

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    21. Avinger Announces Commercial Launch of Ocelot in Australia

      Avinger Announces Commercial Launch of Ocelot in Australia

      First Patients Treated Successfully in Australia with Image-Guided CTO-Crossing Device REDWOOD, CA / ACCESSWIRE / July 8, 2019 / Avinger, Inc. (NASDAQ: AVGR ), a commercial-stage medical device company marketing the first-ever image-guided, catheter-based system for the diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the commercial launch of its Ocelot image-guided chronic total occlusion (CTO) crossing system in Australia. As part of the Company’s exclusive distribution agreement with Diverse Devices Pty Ltd. for Avinger’s proprietary Lumivascular products in Australia, Ocelot completed the registration process with the Therapeutic Goods Administration (TGA) and is included on the Australian Register of Therapeutic ...

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    22. 7^ INTERNATIONAL CONGRESS ON OCT ANGIOGRAPHY AND ADVANCES IN OCT - Rome, December 13 and 14, 2019

      7^ INTERNATIONAL CONGRESS ON OCT ANGIOGRAPHY AND ADVANCES IN OCT - Rome, December 13 and 14, 2019

      The Rome OCT Angiography meeting returns for its 7th edition. OCT Angiography has come a long way since its early days five ago. The preliminary program is outstanding! It can be accessed now on the website. You will get the most recent research results, everyday applications and observe personally the newest devices. Program is mainly Clinical. However, we will have scientific, histology, technology, imaging (5 sessions), wide field, artificial intelligence (4 sessions), a zoom on the treatments of retinal diseases and retinal degeneration. OCTA technology has hugely improved and industrial antagonism is even more dynamic and passionate. World best experts ...

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      Mentions: Bruno Lumbroso
    23. University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy

      University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy

      University of Washington Receives a 2019 NIH Grant for $364,428 for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy. The principal investigator is Ruikang Wang. The program began in 2018 and ends in 2022. Below is a summary of the proposed work. The increasing incidence of diabetes in the US population and the inertial wave of aging in Americans will ensure that diabetic retinopathy (DR) remains one of the principal threats to the sight of adult patients and a significant management challenge for the clinical community. It is now clear that the peripheral retina is the ...

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    24. Aeon Imaging Receives NIH Grant for Confocal and Autofluorescence Imaging of Macular Degeneration Using a Low Cost Digital Imager

      Aeon Imaging Receives  NIH Grant for Confocal and Autofluorescence Imaging of Macular Degeneration Using a Low Cost Digital Imager

      Aeon Imaging Receives a 2019 NIH Grant for Confocal and Autofluorescence Imaging of Macular Degeneration Using a Low Cost Digital Imager. The principal investigator is Mathew Muller. Below is a summary of the proposed work. The overall goal of the proposed SBIR Phase II research is to build and evaluate a low cost, multi-mode retinal camera used to detect and manage causes of macular impairment. Age-related macular degeneration (AMD) remains the most common cause of permanent vision loss in the US and many industrialized countries. Treatments with portable lasers and injectable drugs can save sight, but early detection and careful ...

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