1. Optical Coherence Tomography News

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    1. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      University of Southern California Receives a 2019 NIH Grant for $408,735 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion ...

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    2. Indiana University Receives NIH Grant for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells

      Indiana University Receives NIH Grant for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells

      Indiana University Receives a 2019 NIH Grant for $452,718 for Imaging Spatial and Temporal dynamics of Retinal Ganglion Cells. The principal investigator is Donald Miller. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. Ganglion cells (GCs) and other inner retinal neurons are fundamental to retinal neural circuitry, processing photoreceptor signals relayed from intermediate neurons for transmission to the brain. Yet, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. GCs in particular are lost to neurodegenerative disorders such as glaucoma, Alzheimer’s disease ...

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    3. University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging

      University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging

      University of Houston Receives a 2019 NIH Grant for $676,224 for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging. The principal investigator is David Mayerich The program began in 2019 and ends in 2024. Below is a summary of the proposed work. The ability to correlate between large-scale developmental milestones and micro-scale cellular and protein- specific changes is a significant unmet need in the study of developmental biology. The overall objective of this work is to develop a multi-modality imaging platform that can provide time resolved three-dimensional images of tissue development, with high temporal and spatial ...

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    4. University of Alabama at Birmingham Receives NIH Grant for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression

      University of Alabama at Birmingham Receives NIH Grant for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression

      University of Alabama at Birmingham Receives a 2019 NIH Grant for $635,960 for African Decent and Glaucoma Evaluation (ADAGES) IV: Alternations of the Lamina Cribrosa in Progression. The principal investigator is Massimo Fazio. The program began in 2017 and ends in 2021. Below is a summary of the proposed work. This proposal is focused on morphological changes in the lamina cribrosa with glaucoma onset and progression, and how those changes impact visual function, with a focus on racial disparities. This project leverages on the longitudinal monitoring of a subset of glaucoma patients in the existing ADAGES cohort of which ...

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    5. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2019 NIH Grant for $63,746 for Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for ...

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    6. University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes

      University of Southern California Receives a 2019 NIH Grant for $670,541 for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes. The principal investigator is Brian Applegate. The program began in 2019 and ends in 2022. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin ...

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    7. PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago

      PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago

      A PhD position is available in the Biomedical Optics and Functional Imaging group within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), OCT angiography (OCTA), super-resolution ophthalmoscopy, retinal image analysis and classification ( https://yaolab.bioe.uic.edu/ ). The PhD student will be involved for imaging instrument development and/or experimental study of retinal morphology & physiology. The specific study plan of the student can be flexible based on his/her education background and interest. The successful candidate should have a BS/MS degree in Optical ...

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      Mentions: Xincheng Yao
    8. Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      We have developed a multimodal laser scanning microscope (LSM) platform combining optical coherence tomography (OCT), spectral focusing coherent anti-Stokes Raman scattering (SF-CARS), second harmonic generation (SHG) and two-photon excited fluorescence (TPF). Morphological, molecular and biochemical information from tissues can be collected in a non-invasive and label-free manner by merging ultra-fast Ti:sapphire lasers with well-developed optical imaging techniques. The combination of the proposed imaging modalities enables increased sensitivity and specificity for detection of early tissue alteration related to pathological condition and may offer novel insights in the diagnosis of diseases. OCT is fused with nonlinear optical microscopy techniques to perform ...

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    9. Postdoc in Optics and Biophotonics in the Department of Physical Chemistry of Biological Systems at the Polish Academy of Sciences

      Postdoc in Optics and Biophotonics in the Department of Physical Chemistry of Biological Systems at the Polish Academy of Sciences

      We encourage applicants for Assistant professor (post-doc) position in the Department of Physical Chemistry of Biological Systems at Institute of Physical Chemistry PAS, Warsaw, Poland. This position is a part of the RETURNS project funded by the Polish National Agency For Academic Exchange (NAWA). The RETURNS Project is targeted at development of enhanced polarization contrast optical tomography to improve the outcomes of automatic localization and characterization of malignant tissue. Eligibility criteria: PhD degree in engineering, physics, computer science, mathematics, physiology, biology, or similar; Track record of achievements relative to opportunity; Experience (2-4 years) in at least one of: optical coherence ...

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      Mentions: Karol Karnowski
    10. Heidelberg Engineering Introduces the GMPE Hood Glaucoma Report for SPECTRALIS® OCT

      Heidelberg Engineering Introduces the GMPE Hood Glaucoma Report for SPECTRALIS® OCT

      New feature of the Glaucoma Module Premium Edition offers an intuitive and accurate approach to aid diagnosis and management of glaucoma Heidelberg Engineering, a privately-held imaging and healthcare IT technologies company focused on ophthalmic diagnostic solutions that empower clinicians to improve patient care, announced today that the Hood Glaucoma Report is now available with a software update within the SPECTRALIS OCT Glaucoma Module Premium Edition (GMPE).” The GMPE Hood Glaucoma Report highlights essential diagnostic information in an intuitive layout that enables a quick, yet comprehensive assessment. Based on the diagnostic approach developed by Donald C. Hood, PhD, this report also ...

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    11. David Huang Listed on Ophthalmologist Magazine's 2019 Power List as #1 Inventor!

      David Huang Listed on Ophthalmologist Magazine's 2019 Power List as #1 Inventor!

      We are delighted to share The Ophthalmologist’s Power List 2019 with you. This year saw a record number of nominations – almost 2,000 – across five categories: Champions for Change, Inventors, Emerging Leaders, Mentors, and Surgical Pioneers. Each nomination celebrates an individual who has made a significant impact on the field, whether that is through a philanthropic initiative or their ongoing commitment to innovation. The diversity of the categories – and the huge influx of votes – have brought in many new names. In fact, half of this year’s Power Listers have not been featured before. And 16 of the front-runners ...

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    12. Postdoctoral opening in retinal imaging instrumentation within the Department of Bioengineering, University of Illinois at Chicago

      Postdoctoral opening in retinal imaging instrumentation within the Department of Bioengineering, University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group ( https://yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, retinal image analysis and classification. The postdoctoral fellow will be responsible for instrument development and retinal study. The successful candidate should have a Ph.D. degree in Optical Engineering, Electrical Engineering, Applied Physics or a related discipline. Experience with optical design and construction is essential. Proficiency in Labview and Matlab programming is expected. Hand-on experience ...

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      Mentions: Xincheng Yao
    13. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...

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    14. Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      A postdoctoral research fellow position is available in the Center for Ophthalmic Optics & Lasers Lab ( www.coollab.net ), Casey Eye Institute, Oregon Health & Science University. This is an outstanding opportunity for a candidate to use optical coherence tomography to conduct visual optics research in an academic ophthalmology setting. The researcher on this position will work with a team of scientists, engineers and physicians to develop ultrahigh-performance OCT systems for comprehensive optical characterization of the anterior eye and wide-field ocular surface topography, to improve post-refractive surgery intraocular lens power calculation, therapeutic scleral lens design, diagnosis and classification of corneal shape irregularities ...

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    15. Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures

      Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures

      Conavi Medical Inc. is pleased to announce that it has received a Health Canada Medical Device License for the Novasight Hybrid System. This patented technology is the only clinical system that enables simultaneous imaging of coronary arteries with both intravascular ultrasound (IVUS) and optical coherence tomography (OCT), and was invented at Sunnybrook Research Institute. Angioplasty and stenting is performed four million times around the world every year as an important part of the treatment of coronary artery disease, including patients suffering from heart attacks and angina. Recent randomized studies with existing IVUS systems have shown that intravascular imaging has the ...

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    16. Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head

      Emanuel Hospital and Health Center Receives NIH Grant for IOP-Related Force and Failure in the Optical Nerve Head

      Emanuel Hospital and Health Center Receives a 2019 NIH Grant for $579,552 for IOP-Related Force and Failure in the Optical Nerve Head. The principal investigator is Claude Burgoyne. The program began in 2018 and ends in 2021. Below is a summary of the proposed work. In the previous project period we completed our 3D histomorphometric characterization of connective tissue deformation and remodeling in early through end-stage monkey experimental glaucoma (EG). Based on those findings, in this renewal proposal we will seek to identify important molecular and cellular components of optic nerve head (ONH) connective tissue and retrolaminar myelin remodeling ...

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    17. UC San Diego Receives NIH Grant for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Diseas

      UC San Diego Receives NIH Grant for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Diseas

      University of California at San Diego Receives a 2019 NIH Grant for $392,468 for Diagnostic Innovations in Glaucoma Study (DIGS): High Myoptia and Advanced Disease. The principal investigator is Linda Zangwill. The program began in 2017 and ends in 2022. Below is a summary of the proposed work. This new study, Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced Disease, will overcome barriers to detection of progressive OAG in two cohorts of patients who are among the most challenging clinically to manage, OAG patients with advanced disease (advOAG) and OAG patients with high myopia (mypOAG). Determining whether ...

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    18. Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives NIH Grant for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

      Duke University Receives a 2019 NIH Grant for $761,782 for Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care. The principal investigator is Cynthia Toth. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that may impact vision in vulnerable preterm neonates for a lifetime. Clinical care of infants with ROP decreases the likelihood of blindness, but abnormal vision is common, especially in those with disease severe enough to require treatment. Because it has ...

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    19. Vanderbilt University Receives NIH Grant for In Vivo Molecular Imaging of Vascular Disease of the Retina

      Vanderbilt University Receives NIH Grant for In Vivo Molecular Imaging of Vascular Disease of the Retina

      Vanderbilt University Receives a 2019 NIH Grant for $431,513 for In Vivo Molecular Imaging of Vascular Disease of the Retina. The principal investigator is Imam Uddin. The program began in 2019 and ends in 2024. Below is a summary of the proposed work. Neovascularization (NV) is a common complication in age-related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP) and retinal vein occlusion (RVO). Retinal hypoxia plays an important role during NV development and progression. Thus, in vivo molecular imaging of retinal hypoxia at an early stage could be an important predictive tool assessing the risk of ...

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    20. University of Miami Receives NIH Grant for Intraoperative OCT-Based Wavefront Aberrometer

      University of Miami Receives NIH Grant for Intraoperative OCT-Based Wavefront Aberrometer

      University of Miami Receives a 2019 NIH Grant for $191,875 for Intraoperative OCT-Based Wavefront Aberrometer. The principal investigator is Marco Ruggeri. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. The long term goal of the project is to develop a combined intraoperative aberrometer and Optical Coherence Tomography (OCT) system optimized for cataract surgery guidance. Currently, surgeons rely on eye biometry performed before surgery to make their best guess as to the correct intraocular lens (IOL) power and how to position it inside the eye. The current approach does not deliver ...

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    21. Boston Medical Center Receives NIH Grant for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications

      Boston Medical Center Receives NIH Grant for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications

      Boston Medical Center Receives a 2019 NIH Grant for $669,582 for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications. The principal investigator is Hemat Roy. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. The overall goal of this project is to develop a rectal probe for minimally intrusive highly accurate risk stratification with the vision of utilizing it for a precision medicine approach to colon cancer screening and also potentially chemoprevention (companion biomarker). We will employ cutting edge biophotonics (ISOCT) and biological approaches combined with large scale human studies to elucidate ...

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    22. UC Davis Receives NIH Grant for Mechanisms of Visual Transduction

      UC Davis Receives NIH Grant for Mechanisms of Visual Transduction

      University of California at Davis Receives a 2019 NIH Grant for $438,120 for Mechanisms of Visual Transduction. The principal investigator is Edward Pugh. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Human vision operates over a billion-fold range of light intensities ranging from starlight to bright daylight, with night vision subserved by retinal rod photoreceptor cells, and day vision by cone photoreceptor cells. Rods and cones mediate the first steps in vision by capturing light in their G-protein coupled receptors Rhodopsin, and L/M and S-cone opsins, respectively, whose activation ...

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    23. Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives NIH Grant for Auditory Mechanics and Cochlear Amplificatiom

      Columbia University Receives a 2019 NIH Grant for $428,832 for Auditory Mechanics and Cochlear Amplification. The principal investigator is Elizabeth Olson. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. Sound input to the inner ear (cochlea) causes a frequency-segregated wave-pattern of sensory tissue motion that conveys sound information to the auditory neurons, leading to hearing. A currently untreatable aspect of hearing impairment is the deterioration of the cochlea's ability to sharply segregate sound by frequency. The cochlea's healthy frequency tuning is largely provided by the cochlear amplifier, an ...

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    24. Johns Hopkins University Receives NIH Grant for Intra-Operative, Label-Free Detention of Brain Cancer infiltration with Quantitative Optical Imaging

      Johns Hopkins University Receives NIH Grant for Intra-Operative, Label-Free Detention of Brain Cancer infiltration with Quantitative Optical Imaging

      Johns Hopkins University Receives a 2019 NIH Grant for $589,760 for Intra-Operative, Label-Free Detention of Brain Cancer infiltration with Quantitative Optical Imaging. The principal investigator is Xingde Li The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Glioma is the most common adult primary brain cancer, with inevitable recurrence and finite survival times. Safe maximal resection for glioma patients remains the standard of care based on best evidence medicine (coupled with adjuvant therapies such as radiation and chemotherapy). Multiple studies have shown clear relief of symptoms, improvement of life quality, survival ...

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