1. Optical Coherence Tomography News

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    1. Heidelberg Engineering Supports “Glaucoma / Myopia OCT Phenotyping Consortium”

      Heidelberg Engineering Supports “Glaucoma / Myopia OCT Phenotyping Consortium”

      Heidelberg Engineering is serving as a member of the Glaucoma / Myopia OCT Phenotyping Consortium (GMOPC), in a new effort to support research to improve the detection of glaucoma, the world´s leading cause of irreversible vision loss. The GMOPC was established in February 2020 at an inaugural meeting in Los Angeles, California, as an investigator-initiated clinical research study, with Heidelberg Engineering as an industry partner. The consortium comprises 13 clinical centers in seven countries and provides a new research platform for acquiring OCT images, data storage and retrieval for efficient review, quality control and secure access. Looking beyond established risk ...

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    2. New Jersey Institute of Technology Receives NIH Grant for Optically computed compressive OCT for ultra-high speed phase-resolved dynamic imaging

      New Jersey Institute of Technology Receives NIH Grant for Optically computed compressive OCT for ultra-high speed phase-resolved dynamic imaging

      New Jersey Institute of Technology Received a 2022 NIH Grant for $172,187 for Optically computed compressive OCT for ultra-high speed phase-resolved dynamic imaging. The principal investigator is Xuan Liu. Below is a summary of the proposed work. The objective of this study is to investigate an optically computed compressive optical coherence tomography (OCC- OCT) technology for ultra-high speed phase-resolved dynamic imaging. Optical coherence tomography (OCT) is a cross- sectional imaging modality based on low coherence light interferometry. OCT has been used to image mechanical motion at cellular and tissue level for various biomedical applications. However, the state-of-the-art OCT technology ...

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    3. 4 year funded PhD studentship in Dental OCT at University College London

      4 year funded PhD studentship in Dental OCT at University College London

      Transforming Dental Imaging using Optical Coherence Tomography Primary Supervisor: Dr Peter Munro Clinical Supervisor : Prof Francesco D'Aiuto A 4 year PhD studentship funded by the Royal Society and Department of Medical Physics and Biomedical Engineering is available jointly in the UCL Department of Medical Physics and Biomedical Engineering and the UCL Eastman Dental Institute . Funding will be at least the UCL minimum (£17,609). Ideally, the successful applicant would start as soon as possible. The intended start date is 1st May 2022. The successful candidate will join the UCL CDT in Intelligent, Integrated Imaging in Healthcare (i4health) cohort and ...

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    4. National Eye Institute Receives Intramural 2022 NIH Grant for Evaluation of Visual Function in Animal Models

      National Eye Institute Receives Intramural 2022 NIH Grant for Evaluation of Visual Function in Animal Models

      National Eye Institute Receives Intramural 2022 NIH Grant for $201,678 for Evaluation of Visual Function in Animal Models. The principal investigator is Haohua Qian. Below is a summary of the proposed work. During the past year, we investigated functional regulation of an outer retina hyporeflective band on optical coherence tomography images. In particular, we studied the mechanisms of light-induced OCT responses in rodent eye and examined hypothesis that two light-evoked OCT indices in the outer retina, subretinal space elongation and hyporeflective band reflect two stages in an outer retinal signaling pathway. Human and animal retinal optical coherence tomography (OCT ...

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    5. Avinger Announces $7.6 Million Registered Direct Offering

      Avinger Announces $7.6 Million Registered Direct Offering

      Avinger, Inc. (NASDAQ:AVGR) (the "Company"), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced that it has entered into a definitive agreement with certain institutional investors for the issuance and sale in a registered direct offering of an aggregate of 7,600 shares of Series D convertible preferred stock (the "Preferred Stock") and warrants to purchase up to an aggregate of 16,150,000 shares of common stock for gross proceeds of $7.6 million. The shares of Preferred Stock will have a ...

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      Mentions: Avinger
    6. University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary Motion in PCD

      University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary Motion in PCD

      University of Alabama at Birmingham Received a 2022 NIH Grant for $159,882 for Functional Categorization of Ciliary Motion in PCD. The principal investigator is George Solomon. Below is a summary of the proposed work. Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous disorder of motile cilia that results in progressive lung disease due to abrogated mucociliary clearance. While new understandings of the genetics have been helpful for clinical diagnostics, functional testing of cilia are needed to understand and predict phenotypic variation and response to therapy. Recent work in our laboratory has identified a link between ciliary genetics and novel ...

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    7. Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis

      Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis

      Massachusetts General Hospital Received a 2022 NIH Grant for $480,931 for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis. The principal investigator is Guillermo Tearney. Below is a summary of the proposed work. The diagnosis of most upper GI tract conditions is currently accomplished by upper endoscopy with biopsy (EGD). EGD is costly primarily because it requires conscious sedation, necessitating that procedures be conducted by physicians in a specialized endoscopy suite, and that patients take time away from work and family. Another limitation is sampling error - endoscopic biopsies are frequently random, resulting in many instances ...

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    8. University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

      University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

      University of Southern California Received a 2022 NIH Grant for $516,925 for Mechanisms of cochlear synaptopathy after noise or blast trauma. The principal investigator is John Oghalai. Below is a summary of the proposed work. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic ...

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    9. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      Massachusetts Eye and Ear Infirmary Received a 2022 NIH Grant for $488,619 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear motion, new techniques such as optical coherence tomography (OCT) have instead revealed not only that the reticular lamina (RL) moves in a different pattern from the BM, but that it ...

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    10. Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

      Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

      Washington University Received a 2022 NIH Grant for $492,557 for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart. The principal investigator is Chao Zhou. Below is a summary of the proposed work. Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subsequent sustained episode of ischemia. An emerging body of evidence demonstrated that neural regulated heart rate modulation confers cardiac preconditioning responses. Understanding the mechanism through model systems of preconditioning would help us identify the genes and proteins when ...

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    11. Medical College of Wisconsin Receives 2022 NIH Grant for Otitis Media Diagnosis and Treatment

      Medical College of Wisconsin Receives 2022 NIH Grant for Otitis Media Diagnosis and Treatment

      Medical College of Wisconsin received a 2022 NIH Grant for $576,383 for Otitis Media Diagnosis and Treatment. The principal investigator is Joseph Kerchner. Below is a summary of the proposed work. Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States (1,2), affects 90% of all children (3,4) and is the most common indication for antimicrobial therapy and surgery (5) in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity (1,3,6-30). OM continues ...

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    12. University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes

      University of Southern California Receives NIH Grant for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes

      University of Southern California received a 2022 NIH Grant for $586,520 for Optical Imaging Technologies to Identity Residual Cholesteatoma and Improve Ossiculplasty Outcomes. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There are a number of diseases and conditions in the middle ear that cause hearing loss in both children and adults. In children it is particularly important to expedite interventions to restore hearing since it negatively impacts language development and academic performance. An example is cholesteatoma, a benign lesion due to abnormal skin growth in the middle ear which facilitates erosion of ...

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    13. Massachusetts General Hospital Receives NIH Grant for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives NIH Grant for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives a 2022 NIH Grant for $582,146 for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy. The principal investigator is Melissa Suter. Below is a summary of the proposed work. Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread offering patients little hope for cure (average 5-year survival rate < 15%). The U.S. Preventive Services Task Force recommends individuals at high risk of developing lung cancer undergo yearly screening with low dose computed tomography (LDCT). Screening ...

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    14. Senior Software Engineer, Team Leader Opening at Aquyre Biosciences

      Senior Software Engineer, Team Leader Opening at Aquyre Biosciences

      Job Title: Senior Software Engineer, Team Leader / Manager (Clinical Data, AI, Device) Date: December 2021 Contract: Full-time Location: Paris with trips to Boston Salary: Competitive based on skills and experience Qualification: BS in Computer Science or equivalent engineering fields Minimum experience: 10 years LLTech – Aquyre Biosciences LLTech / Aquyre develops and sells systems that capture data from fresh biopsies, in the operating room, for real-time biopsy assessment and cancer diagnosis. Our unique data provides information on intracellular activity. The main applications are in the diagnosis of cancer such as lung, breast, prostate, liver Principal Duties and Responsibilities: Build and Manage software ...

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    15. PhD Student Opening in Advanced Imaging at Indiana University

      PhD Student Opening in Advanced Imaging at Indiana University

      A PhD student position is available in Don Miller’s laboratory on advanced ophthalmic imaging at Indiana University ( www.MillerImagingLab.org ). The laboratory is looking for a highly motivated student in engineering, optical physics, or a related discipline with an interest to develop cutting-edge optical instrumentation to study noninvasively the retina at the cellular level. The laboratory’s primary focus is on the development and use of adaptive optics and optical coherence tomography, technologies the laboratory has been advancing for the past two decades. Some of our recent work can be found in PNAS: https://www.pnas.org/content/118 ...

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    16. Conavi Medical Enters into Funding Agreements for Over $20 Million to Support Commercialization of its Innovative Intravascular Image Guidance Technology

      Conavi Medical Enters into Funding Agreements for Over $20 Million to Support Commercialization of its Innovative Intravascular Image Guidance Technology

      Conavi Medical Inc. ( www.conavi.com ), a leader of hybrid imaging guidance for common minimally invasive heart procedures, has entered into agreements for over $20 million in funding to support commercialization and growth as it prepares its innovative Novasight Hybrid® System for market. The company aims to raise an additional $10 million as part of an ongoing financing effort. Conavi Medical is leading the way with its Novasight Hybrid System as a new imaging platform for use by interventional cardiologists during common minimally invasive heart procedures. This patented technology is the first and only clinical system that enables simultaneous and ...

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    17. Perimeter Medical Imaging AI Announces Initiation of First Clinical Trial Site at West Cancer Center & Research Institute in Tennessee

      Perimeter Medical Imaging AI Announces Initiation of First Clinical Trial Site at West Cancer Center & Research Institute in Tennessee

      Perimeter Medical Imaging AI, Inc. (TSX-V:PINK)(OTC:PYNKF) (FSE:4PC) (“Perimeter” or the “Company”), a medical technology company driven to transform cancer surgery with ultra-high-resolution, real-time, advanced imaging tools to address high unmet medical needs, announced the initiation of a multi-center, randomized, two-arm pivotal clinical trial to evaluate its Perimeter B-Series OCT with ImgAssist AI for use during breast conservation surgery. The first patient procedures were performed by Richard E. Fine, MD and Michael Berry, MD, leading breast surgeons based out of the Margaret West Comprehensive Breast Center in Germantown, Tennessee. Dr. Richard E. Fine, Director of Education & Research ...

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    18. Perimeter Medical Imaging AI Announces Strategic Private Placement to Social Capital (C$43.4 million)

      Perimeter Medical Imaging AI Announces Strategic Private Placement to Social Capital (C$43.4 million)

      Perimeter Medical Imaging AI, Inc. (TSX-V:PINK)(OTC:PYNKF) (FSE:4PC) (“Perimeter” or the “Company”), a medical technology company driven to transform cancer surgery with ultra-high-resolution, real-time, advanced imaging tools to address high unmet medical needs, today announced that it has entered into a subscription agreement pursuant to which an affiliate of Social Capital Holdings Inc. (“Social Capital”) will make a strategic C$43.4 million investment in the Company. Jeremy Sobotta, Perimeter’s Chief Executive Officer stated, “We believe Social Capital’s investment marks a transformative, pivotal event for Perimeter that will help accelerate our growth. This strategic partnering ...

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    19. Notal Vision Monitoring Center Reports AI Analysis of 10 Million ForeseeHome® AMD Home Monitoring Tests

      Notal Vision Monitoring Center Reports AI Analysis of 10 Million ForeseeHome® AMD Home Monitoring Tests

      The Notal Vision Monitoring Center celebrates the artificial intelligence (AI) based analysis of the ten millionth test performed by over 20,000 patients with the FDA-cleared ForeseeHome device. The device is part of a comprehensive remote monitoring service for intermediate age-related macular degeneration (AMD) patients at risk of developing the sight threatening wet form of the disease. The service monitors patients between office eye exams, when it’s difficult to manage the acute onset of wet disease that requires timely treatment. A recent large scale data analysis showed that the use of ForeseeHome provided a significant benefit to patients by ...

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      Mentions: Notal Vision
    20. Instructor in Optical Coherence Tomography (OCT) in the Tearney Laboratory

      Instructor in Optical Coherence Tomography (OCT) in the Tearney Laboratory

      The Tearney Laboratory at the Wellman Center for Photomedicine, Massachusetts General Hospital, is recruiting for Instructor faculty position at Harvard Medical School. The Tearney Lab pioneers the invention, development, and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body. One of the most powerful such technologies is optical coherence tomography (OCT) that captures cross-sectional and three-dimensional microscopic images of tissue. We are seeking a motivated researcher to join our team to play a direct role in advancing our research and scientific agenda. The Instructor will work in a ...

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    21. Postdoc Position at the University of Southern California

      Postdoc Position at the University of Southern California

      A postdoctoral researcher position is available immediately in the Keck School of Medicine. The successful candidate will work on highly collaborative projects for functional imaging with Optical Coherence Tomography. The collaboration includes researchers in the departments of Otolaryngology (John Oghalai, MD), Ophthalmology (Narsing Rao, MD, Mark Humayun, MD,PhD), and Biomedical Engineering (Scott Fraser, PhD, Qifa Zhou, PhD). The projects involve the development of highly phase-stable optical systems for human in vivo imaging of nanoscale vibrations in the ear, blood flow in the inner ear and blood flow deep in the eye’s choroidal vasculature. There is also opportunity to ...

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    22. Postdoc Opening in Optical Coherence Tomography Angiography at Nanyang Technological University

      Postdoc Opening in Optical Coherence Tomography Angiography at Nanyang Technological University

      We are looking for a postdoc fellow to do Optical Coherence Tomography Angiography (OCTA) projects. Strong knowledge in image processing and image data analysis is preferred. Those interested could send cv to Prof. Liu. Details are as below: Research Interests: My research interests are mainly focused on the development and validation of non-invasive, cellular, and sub-cellular resolution imaging methods for disease diagnosis and life science research. Postdoctoral fellow position in high-resolution optical coherence tomography (OCT) devices. The successful candidate will work on a collaborative research project with a focus on micro-optical coherence tomography, synthetic aperture endoscopy, and point-of-care optical imaging ...

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    23. Avinger Announces FDA Clearance of Pantheris for the Treatment of In-Stent Restenosis

      Avinger Announces FDA Clearance of Pantheris for the Treatment of In-Stent Restenosis

      Avinger, Inc. (NASDAQ:AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced that it has received 510(k) clearance from the U.S. Food & Drug Administration (FDA) for a new clinical indication for the Pantheris image-guided atherectomy system. This clearance allows the company to directly market Pantheris for the treatment of in-stent restenosis (ISR) in the lower extremity arteries. "We are excited to receive FDA clearance for the ISR indication, which expands our addressable market for Pantheris to include a high-incidence disease state ...

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    24. MicroPort® Invests ~$58M for 51% of IV-OCT Imaging Start-up Argus

      MicroPort® Invests ~$58M for 51% of IV-OCT Imaging Start-up Argus

      MicroPort Scientific Corporation (00853.HK, “MicroPort ® ”) signed a strategic investment agreement with Suzhou Argus Medical Technology Co., (“Argus”) and the related parties. Under the agreement, MicroPort ® will directly invest in Argus and acquire part of the equity from the existing shareholders, with total cost of RMB 372.3 million. After completion of the transaction, MicroPort ® will become the controlling shareholder of Argus, with 51% equity interest in Argus. Founded in Suzhou Industrial Park in 2016, Argus focuses on solutions for intravascular OCT systems, and has successfully developed ArgusClarity™ OCT system and Argus NOPURGE TM purge-free disposable imaging catheter independently. ArgusClarity ...

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