1. Optical Coherence Tomography News

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    1. Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives a 2021 NIH Grant for $468,446 for Multi-contrast dynamic optical imaging to advance live developmental biology. The principal investigator is Shang Wang. Below is a summary of the proposed work. Imaging is essential for the study of developmental biology. In particular, optical imaging, with its high resolution, has been making revolutionary impacts on our understanding of biological development. To a large degree, the imaging capability defines what can be studied in developmental biology. From 2D to 3D, from static to dynamic, advancements in optical imaging have enabled us to connect molecular genetics with volumetric ...

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    2. New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives a 2021 NIH Grant for $468,446 for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography. The principal investigator is Vivek Srinivasan. Below is a summary of the proposed work. The earliest changes in the photoreceptors, retinal pigment epithelium, and Bruch’s membrane in age-related macular degeneration (AMD) are subtle and challenging to detect non-invasively. Here, we will develop and validate a new in vivo imaging technology, visible light Optical Coherence Tomography (OCT), which, if implemented carefully, delineates these layers with unprecedented depth resolution and functional contrast. The ability to precisely ...

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    3. Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives a 2021 NIH Grant for $468,446 for Enabling technology for image-guided robot-assisted sub-retinal injections. The principal investigator is Iulian Iordachita. Below is a summary of the proposed work. The goal of this proposal is to design, develop and evaluate a novel clinically compatible surgical platform for enhancing the retina surgeon's ability to provide therapy to the subretinal domain. Efficient, safe, reproducible delivery methods would enable safe and precise delivery of stem cell, nanoparticle and gene therapies for prevalent ocular diseases including but not limited to Age-related Macular Degeneration (AMD). The proposed cooperative surgical robot ...

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    4. Mechanical Engineer Endoscopy Job Opening at Glannaventa

      Mechanical Engineer Endoscopy Job Opening at Glannaventa

      Glannaventa is currently seeking an enthusiastic, creative medical device engineer to design, develop and implement critical components of the next-generation GEODE™ micro-endoscope and associated delivery system as part of our quest to develop an outpatient screening test for high-grade serous ovarian cancer. The majority of HGSOC, the most lethal histotype of ovarian cancer, is believed to originate in the epithelia of the distal Fallopian tubal structures, and then moves to the ovary and peritoneum, becoming aggressive and metastatic. Contemporary imaging and screening techniques do not have the resolution, sensitivity or specificity to permit early detection of the disease, so it ...

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    5. Wasatch Photonics announces the appointment of Neil Anderson as Vice President, Gratings and OCT

      Wasatch Photonics announces the appointment of Neil Anderson as Vice President, Gratings and OCT

      Wasatch Photonics is pleased to announce and welcome Neil Anderson, Ph.D. as the new Vice President of Gratings and OCT. In this role, Neil will be responsible for commercial leadership and growth of the company’s transmission gratings and optical coherence tomography business, working with the teams in Logan, UT, and Morrisville, NC, to develop innovative product solutions matched to current and emerging market needs in laser pulse compression, optical coherence tomography (OCT), astronomy, and photonics. Neil is a well-known and respected figure in the optics and photonics industry and brings 15 years of experience supporting customers with optical ...

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    6. Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital

      Employer Description Guillermo J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities ...

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    7. Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Employer Description Guillermo J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities ...

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    8. Ophthalmic Systems Architect at Zeiss

      Ophthalmic Systems Architect at Zeiss

      JOB SUMMARY: The Ophthalmic Systems Architect is responsible for driving systems architecture design, trade-off analysis, implementation, and validation across cloud-ready ophthalmic diagnostics products. This role collaborates with various functions within ZEISS to define systems requirements for performance, cost, manufacturability, serviceability, and reliability from hardware through software and user experience. The Ophthalmic Systems Architect works from concept phase through commercial launch to ensure meeting customer needs and exceeding their expectations. Deep passion and experience in developing consumer products from prototyping through productization is crucial for success in this role. ESSENTIAL FUNCTIONS: (Responsibilities that are central to the job and MUST be ...

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    9. Senior Scientist Opening at Carl Zeiss Meditec, Inc-Dublin, CA

      Senior Scientist  Opening at Carl Zeiss Meditec, Inc-Dublin, CA

      JOB SUMMARY: The Senior Scientist is responsible for the initiation, design, development, and implementation of scientific research projects to explore technology for future platform concepts and support the development and execution of product roadmaps. Will investigate the feasibility of applying scientific principles and concepts to potential inventions and products. Maintains substantial knowledge of state-of-the-art principles and theories and may contribute to scientific literature and conferences. May participate in development of intellectual property and visit clinical sites and interact with the market to provide inputs to the R&D teams about various possible system design improvements. May identify and work with ...

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    10. University of Arizona Receives NIH Grant for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting

      University of Arizona Receives NIH Grant for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting

      University of Arizona Receives a 2021 NIH Grant for $693,571 for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting . The principal investigator is Rongguang Liang. Below is a summary of the proposed work. Oral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancer worldwide, accounting for 400,000 new cancer cases each year. Two-thirds of these cancers occur in low- and middle-income countries (LMICs). While the 5-year survival rate in the U.S. is 62%, the survival rate is only 10- 40% and cure rate around 30% in ...

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    11. University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement

      University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement

      University of North Carolina Receives a 2021 NIH Grant for $797,092 for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement. The principal investigator is Amy Oldenburg. Below is a summary of the proposed work. Subglottic stenosis (SGS) is one of the most common life-threatening airway disorders in infants and children. Current treatment methods are based on airway endoscopy, which provides only qualitative information. Surgical treatment failures for the most severe grades of SGS range toward 50%, often due to post-operative airway collapse in new, unpredicted locations. Treatment ...

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    12. MGH Receives NIH Grant for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging

      MGH Receives NIH Grant for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging

      Massachusetts General Hospital Receives a 2021 NIH Grant for $210,000 for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging. The principal investigator is Hui Wang. Below is a summary of the proposed work. Development of the human cerebellum undergoes a precisely programmed sequence of processes, spanning from the third trimester of pregnancy into the first postnatal year. Due to advances in neonatal imaging techniques, cerebellar injury has been increasingly detected in premature infants and full-terms with birth complications. Although perinatal cerebellar injury and malformation have been broadly associated with developmental delays in motor, language, cognition, and ...

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    13. University of Alabama Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama Receives NIH Grant  for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama at Birmingham Receives a 2021 NIH Grant for $258,726 for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease. The principal investigator is Yuqiang Bai. Below is a summary of the proposed work. In humans, the precorneal tear film (PCTF) is a thin layer (~3-5 µm) of a complex biological fluid coating the ocular surface, that serves to nourish and protect the ocular surface and provide a smooth refractive optical surface for vision. In dry eye disease, the PCTF becomes thinner, and destabilizes (evaporates ...

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    14. MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2021 NIH Grant for $198,000 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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    15. Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT evaluation to reveal early-stage changes in glaucoma

      Legacy Emanuel Hospital and Health Center Receives NIH Grant for Advancing OCT evaluation to reveal early-stage changes in glaucoma

      Legacy Emanuel Hospital and Health Center Receives a 2021 NIH Grant for $683,321 for Advancing OCT evaluation to reveal early-stage changes in glaucoma. The principal investigator is Brad Fortune. Below is a summary of the proposed work. Currently, diagnosis of glaucoma and patient management decisions are often informed by thinning of the optic nerve head (ONH) neuro-retinal rim, peripapillary retinal nerve fiber layer (RNFL), and macular inner retinal layers, as detected using optical coherence tomography (OCT). These measurements are useful because they are predictive of subsequent visual field decline, and of faster rates of subsequent thinning. However, by the ...

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    16. Washington University Receives NIH Grant for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids

      Washington University Receives NIH Grant for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids

      Washington University Receives a 2021 NIH Grant for $347,287 for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids. The principal investigator is Chao Zhou. Below is a summary of the proposed work. More than 90% of the drugs being developed fail because of lack of efficacy or unexpected toxicity in clinical trials. This failure rate in the late stages of clinical development is in large part due to the use of overly simplistic in vitro cell assays, and in vivo animal models with limited predictive value during the various stages ...

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    17. Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives a 2021 NIH Grant for $683,321 for Optically guided catheter ablation of atrial fibrillation. The principal investigator is Andrew Rollins. Below is a summary of the proposed work. Atrial fibrillation (AF) affects approximately 3 million patients and its prevalence is expected to rise as the population ages. Catheter ablation, the preferred treatment strategy for symptomatic patients, creates local regions of tissue necrosis in the atria called lesions that are meant to abolish abnormal electrical activity that causes AF. However, AF recurrence is significant in these patients mostly due to inadequate lesions formed by ablation ...

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    18. UCSD Receives NIH Grant for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

      UCSD Receives NIH Grant for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

      University of California at San Diego Receives a 2021 NIH Grant for $117,347 for Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography . The principal investigator is Mark Christopher. Below is a summary of the proposed work. Primary open angle glaucoma (POAG) is a leading cause of blindness in the United States and worldwide. It is estimated that over 2.2 million Americans suffer from POAG and that over 130,000 are legally blind from the disease. As the population ages, the number of people with POAG in the United States will increase ...

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    19. Avinger Announces 510(k) Filing for New Lightbox 3 Imaging Console

      Avinger Announces 510(k) Filing for New Lightbox 3 Imaging Console

      Smaller Footprint, Improved User Experience and Lower Cost to Drive Adoption Avinger, Inc. (NASDAQ:AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the submission of a 510(k) application to the U.S. Food & Drug Administration (FDA) for its new Lightbox 3 imaging console. "Avinger's Lightbox 3 represents an important leap forward in imaging, portability and capability," commented Jeff Soinski, Avinger's President and CEO. "The Lightbox 3's compact size, next generation laser system and streamlined workflows are anticipated to ...

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      Mentions: Avinger
    20. Abbott Receives FDA Clearance for its Imaging Technology Using Artificial Intelligence for Vessels in the Heart

      Abbott Receives FDA Clearance for its Imaging Technology Using Artificial Intelligence for Vessels in the Heart

      Ultreon™ 1.0 Software, the first-of-its-kind imaging software, merges optical coherence tomography with the power of automation using Artificial Intelligence The new intuitive interface provides step-by-step guidance to enhance ease of use When combined with Abbott's Dragonfly OpStar™ imaging catheter and PressureWire X™, the platform provides physicians with a comprehensive set of tools to provide better patient care Abbott (NYSE: ABT ) today announced it has received U.S. Food and Drug Administration (FDA) clearance for its latest optical coherence tomography (OCT) imaging platform powered by the company's new Ultreon Software. This innovative imaging software combines OCT with artificial ...

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      Mentions: Abbott FDA
    21. Optical (OCT) Physicist Opening at Cylite Pty Ltd

      Optical (OCT) Physicist Opening at Cylite Pty Ltd

      Cylite: Cylite is a technology company operating at the cutting edge of optical imaging systems for ophthalmic and related markets. We are in the process of launching a highly innovative product based on Hyper-Parallel Optical Coherence Tomography (HP-OCT) for high-speed imaging of the eye. Production of these instruments is done at our cleanroom facility, using highly sophisticated optical alignment and manufacturing processes. The company is based in Notting Hill, Melbourne, adjacent to the Monash University Science and Technology Precinct, and provides a collaborative, inclusive, and stimulating work environment. We are looking for a talented Optical (OCT) Physicist to join our ...

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      Mentions: Cylite
    22. Carl Zeiss Meditec Takes Insight Photonics Solutions to Court for Breach of Contract Seeking $150M in Damages

      Carl Zeiss Meditec Takes Insight Photonics Solutions to Court for Breach of Contract Seeking $150M in Damages

      UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF NEW YORK CARL ZEISS MEDITEC, INC., Civil Action No. Plaintiff, Complaint v. INSIGHT PHOTONICS SOLUTIONS, INC., Defendant. Plaintiff Carl Zeiss Meditec, Inc. ("Zeiss"), by its attorneys, Dorsey & Whitney LLP, for its Complaint against Defendant Insight Photonics Solutions, Inc. ("Insight"), states as follows: INTRODUCTION 1. This action arises out of Insight's willful and bad faith breaches of a 2017 development agreement (the "Development Agreement") by and among Zeiss, Insight, and a joint venture between Zeiss and Insight, called Ophthalmic Laser Engines, LLC ("OLE"). Under the Development Agreement, Insight was obligated to develop ophthalmic ...

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    23. Massachusetts General Hospital Receives NIH Grant for Blood flow-based guidance and diagnostics using OCT

      Massachusetts General Hospital Receives NIH Grant for Blood flow-based guidance and diagnostics using OCT

      Massachusetts General Hospital Receives a 2021 NIH Grant for $128,304 for Blood flow-based guidance and diagnostics using OCT. The principal investigator is Nestor Uribe-Patarroyo Below is a summary of the proposed work. Diseases diagnosed with assessment of blood flow account for 29% of deaths in the US and are leading causes of premature morbidity, including visual disorders which carry an economic burden of $35 billion per year. The heart disease with the most impact on public health is coronary artery disease (CAD); more than one million percutaneous coronary interventions (PCI) are performed in the US every year. Among visual ...

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    24. White Paper on Superluminscent Diodes by Anritsu

      White Paper on Superluminscent Diodes  by Anritsu

      Sensing systems using optical fibers as well as spectroscopic techniques using light absorption in the near-infrared domain of organic molecules are making remarkable advances and the need for light sources for even higher-performance sensing is accelerating. In these circumstances, the Super Luminescent Diode (SLD) is being adopted as a light source for optical-fiber sensing applications due to its broad optical spectrum with an output power matching LDs and low coherence, while featuring excellent optical fiber coupling efficiency.

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