1. Optical Coherence Tomography News

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    1. University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives NIH Grant for Cochlear Mechanics in the Mouse

      University of Southern California Receives a 2019 NIH Grant for $215,469 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex ...

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    2. Stanford University Receives NIH Grant for Structural and Functional Tests of Ganglion cell Damage in Glaucoma

      Stanford University Receives NIH Grant for Structural and Functional Tests of Ganglion cell Damage in Glaucoma

      Stanford University Receives a 2019 NIH Grant for $360,264 for Structural and Functional Tests of Ganglion cell Damage in Glaucoma. The principal investigator is Anthony Morcia. The program began in 2019 and ends in 2023. Below is a summary of the proposed work. This project will use a combination of structural and functional measurements to test the hypothesis that early- stage damage in human glaucoma occurs first in the inner plexiform layer (IPL) of the retina – especially its OFF sub-lamina – as suggested by murine glaucoma models. In the first Aim, we will use a novel visible-light optical coherence tomograph ...

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    3. OHSU Receives NIH Grant ffor Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

      OHSU Receives NIH Grant ffor Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

      Oregon Health and Science University Receives a 2019 NIH Grant for $250,000 for Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas. The principal investigator is Yan Li. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. To see well, the cornea must maintain near perfect clarity and shape. Several disease processes can distort corneal shape and degrade vision. These include ectasia/keratoconus (stromal thinning and bulging), primary epithelial deformation (contact lens-related warpage, dry eye, epithelial basement membrane dystrophy), and stromal changes (scar, stromal dystrophy, surgery). Some of these conditions ...

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    4. University Houston ReceivesNIH Grant for Optical Coherence Elastography of the Cornea

      University Houston ReceivesNIH Grant for Optical Coherence Elastography of the Cornea

      University Houston Receives a 2019 NIH Grant for $379,941 for Optical Coherence Elastography of the Cornea. The principal investigator is Kirill Larin. The program began in 2012 and ends in 2020. Below is a summary of the proposed work. The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement ...

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    5. OHSU Receives NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy

      OHSU Receives NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy

      Oregon Health and Science University Receives a 2019 NIH Grant for $281,474 for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy. The principal investigator is Yali Jia. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. Our group has demonstrated that optical coherence tomography angiography (OCTA) can address many of the disadvantages of fluorescein angiography (FA) in diabetic retinopathy (DR). OCTA uses the intrinsic contrast of blood cell motion and therefore does not require dye injection, making it entirely non-invasive and suitable for routine examination. OCTA is three-dimensional and can ...

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    6. Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation

      Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation

      Duke University Receives a 2019 NIH Grant for $150,000 for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation. The principal investigator is Joseph Izatt. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. This is an application for an Exploratory/Developmental Research Grant which brings together a team of experts in ophthalmic imaging, surgery and robotics to advance the state of the art in image-guided robotic microsurgical intervention. Corneal transplants are one of the most commonly performed allograft procedures worldwide, although there remains a substantial risk of immune ...

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    7. UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Auytoflourescence Fundus Camera For Age-Related Macular Degeneration

      UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Auytoflourescence Fundus Camera For Age-Related Macular Degeneration

      University of Illinois at Urbana Champaign Receives a 2019 NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Auytoflourescence Fundus Camera For Age-Related Macular Degeneration. The principal investigator is Liang Giao. Below is a summary of the proposed work. An imaging modality that allows for fast, simultaneous, noninvasive probing of both 3D cellular resolution retinal morphology by optical coherence tomography (OCT) and molecular-specific functions by autofluorescence (AF) could substantially improve both basic understanding and the early diagnosis of age- related macular degeneration (AMD), the leading cause of blindness in the developed world. The evaluation and management of AMD utilize several ...

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    8. Permanent Professor Position available at University of Lubeck

      Permanent Professor Position available at University of Lubeck

      The Institute of Biomedical Optics at the Department of Computer Science/Engineering and Department of Natural Sciences (STEM) at the Universität zu Lübeck invites applications for a permanent University Professorship (W2) in Biomedical Optics and Photonics commencing as soon as possible. Conditions of the appointment are in accordance with the Higher Education Act (Hochschulgesetz) of Schleswig Holstein. Details will be explained on request. The successful candidate will represent the respective field in research and teaching. The overall focus of the professorship lies on novel physics approaches in optics and their development to the point of application in the ...

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    9. PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc., a medical device company headquartered in Champaign, Illinois, announces successful initiation of a multi-site registered clinical study to evaluate the imaging capabilities and image analysis performance of the PhotoniCare TOMi Scope. Children’s National Health System (Washington, D.C.) is the first initiated of two clinical sites involved in this registered multi-site clinical study, along with Carle Foundation Hospital (Urbana, Illinois). The study is led by Dr. Diego Preciado, Children’s National, and Dr. Ryan Porter, Carle Hospital, along with a team of recognized otitis media experts at both clinical sites. This multi-center study plans to enroll a ...

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    10. Feature Of The Week 04/28/2019: Real-Time High-Resolution Mid-Infrared OCT

      Feature Of The Week 04/28/2019: Real-Time High-ResolutionMid-Infrared OCT

      The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4 µm and an axial resolution of 8.6 µm is demonstrated. The system produces two-dimensional cross-sectional images ...

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    11. Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis

      Position description: The Z-lab led by Prof. Chao Zhou is moving to the Biomedical Engineering Department at the Washington University in St. Louis in the summer of 2019 ! Multiple Postdoctoral Associate positions in Biophotonics / Biomedical Optical Imaging are available. We are looking for highly motivated individuals to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Successful candidates will have opportunities to collaborate with top academic and industry partners . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on hardware and programming experience ...

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    12. Postdoctoral Opportunity in Optics at the Backman Biophotonics Laboratory Northwestern University

      Postdoctoral Opportunity in Optics at the Backman Biophotonics Laboratory Northwestern University

      Our laboratory is a pioneer in the development of novel super-resolution imaging and nano-sensing techniques, and currently has two optics-related openings for postdoctoral fellows as described below. For either role, candidates must have a Ph.D. in biomedical engineering, electrical engineering, medical physics, or a related field. The successful candidates are expected to possess excellent written and oral communication skills in English, a good publication record in peer-reviewed journals, and be highly motivated and with demonstrable experience in modern optics. One position is focused on developing endoscopic optical coherence tomography (OCT) technologies to quantitatively study changes to microvascular function and ...

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    13. ADAPTIVE OPTICS OPHTHALMOSCOPY CONFERENCE SEPTEMBER 4TH, PARIS

      ADAPTIVE OPTICS OPHTHALMOSCOPY CONFERENCE SEPTEMBER 4TH, PARIS

      Late Summer Course - September 4 & 5, 2019 - Paris High resolution imaging technologies, exemplified by adaptive optics ophthalmoscopy (AOO) and optical coherence tomography (OCT) are progressively transferring from the lab to the clinic. This is an opportunity to better understand retinal diseases, to optimize their management but also to provide novel biomarkers for other medical specialities. However, there is still an unmet need in the field of clinical interpretation of AOO images, and more importantly in the integration of AOO into clinical practice. The late summer course on adaptive optics ophthalmoscopy , that will take place in Paris, on September the 4th ...

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    14. Postdoctoral Research Fellow Position within the PARIS High Resolution Retinal Imaging Group

      Postdoctoral Research Fellow Position within the PARIS High Resolution Retinal Imaging Group

      A postdoctoral research fellow position is available within the PARIS high resolution retinal imaging group at the Quinze Vingts National Ophthalmology Hospital and Vision Institute in Paris, France. This is an excellent opportunity for a candidate to use adaptive optics ophthalmoscopy (AOO) and optical coherence tomography to conduct visual optics research in a clinical ophthalmology setting. The postdoc will work with a team of clinicians, engineers and scientists to develop, adapt and apply novel AOO modalities to imaging retinal disease in the context of a multi-centric project funded by the European Research Council (ERC), involving renowned partners expert in high ...

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    15. Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition

      Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition

      Boston Medical Center Receives a 2019 NIH Grant for $197,189 for Eye To Brain: Eye Biomarkers and Cognition. The principal investigator is Manju Subramanian. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. The goal of our research is to identify ocular biomarkers that have diagnostic and potentially prognostic utility in Alzheimer's Disease (AD), and establish a relationship to cognition. We seek to determine this relationship in an already established cohort of patients (the Vitreous Biomarkers Study, or VBS) with eye disease where protein biomarkers have been identified in the ...

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    16. Research Associate / Postdoctoral Fellow in Adaptive Optics and Optical Coherence Tomography at Indiana University

      Research Associate / Postdoctoral Fellow in Adaptive Optics and Optical Coherence Tomography at Indiana University

      The Advanced Ophthalmic Imaging Laboratory at Indiana University is looking to fill a postdoctoral fellow or research associateposition. The successful candidate will join a team of scientists and engineers that are developing adaptive optics–optical coherence tomography (AO-OCT) for studying structure and function of the living human retina at the cellular level. The system is opening exciting new directions to study both normal and pathological vision. The laboratory ( www.opt.indiana.edu/dtmiller/Index.aspx ) is part of an active and well-funded community of vision scientists and engineers working in the areas of visual optics, retinal imaging, OCT, and adaptive ...

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    17. Physical Sciences Receives NIH Grant for Optical Prove for Real-Time Assessment of Periodontal Health Status

      Physical Sciences Receives NIH Grant for Optical Prove for Real-Time Assessment of Periodontal Health Status

      Physical Sciences Incorporated Received a 2019 NIH Grant for $641,715 for Optical Prove for Real-Time Assessment of Periodontal Health Status. The principal investigator is Nicusor Iftimia. The program began in 2013 and ends in 2020. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA is proposing to develop a technology that will address a major unmet medical need in periodontology: the lack of tools to quantitatively and objectively assess the health/disease status of the gingival soft tissues. The proposed technology will combine high resolution micro-Optical Coherence Tomography ...

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    18. Avinger Announces Publication of Study Demonstrating Positive Clinical Outcomes for Patients Treated with Pantheris Prior to Antirestenotic Therapy

      Avinger Announces Publication of Study Demonstrating Positive Clinical Outcomes for Patients Treated with Pantheris Prior to Antirestenotic Therapy

      Avinger, Inc. (NASDAQ: AVGR ), a leading developer of image-guided, catheter-based systems for the diagnosis and treatment of patients with Peripheral Artery Disease (PAD), today announced the publication of very promising clinical outcomes data from a study evaluating the performance of the Pantheris® Lumivascular atherectomy system combined with antirestenotic therapy in the treatment of PAD. This retrospective single-center, single-arm study has been published in the April 2019 issue of the peer-reviewed Journal of Cardiovascular Surgery under the title "Optical Coherence Tomography Guided Directional Atherectomy with Antirestenotic Therapy for Femoropopliteal Arterial Disease." The study analyzed the clinical outcomes of 33 patients (37 ...

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    19. Perimeter Medical Imaging Inc Announces 510(k) Clearance by FDA

      Perimeter Medical Imaging Inc Announces 510(k) Clearance by FDA

      Perimeter Medical Imaging, Inc. (“Perimeter Medical”) announced today that the company received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market the second generation of their platform imaging tool used in the evaluation of human tissue microstructure by providing two-dimensional, cross-sectional, real-time depth visualization. Enhancements to the newly cleared OTIS™ 2.0 system over the previous generation include: A novel specimen positioning consumable feature Touchscreen interface with improved software, designed to streamline integration with existing clinical workflow 10x faster image acquisition speed Perimeter has developed a world class proprietary reference atlas, with correlations between OTIS ...

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    20. Post-doctoral Adaptive Optics Research Fellow at U.S. Food and Drug Administration

      Post-doctoral Adaptive Optics Research Fellow at U.S. Food and Drug Administration

      Seeking a highly motivated post-doctoral Adaptive Optics Research Fellow to work at the U.S. Food and Drug Administration, Center for Devices and Radiological Health. The candidate will work in the Division of Biomedical Physics under the direction of Drs. Zhuolin Liu and Daniel X. Hammer and perform research with the FDA multimodal adaptive optics (mAO) imager. The FDA mAO imaging system allows visualization of different retinal cells, including ganglion cells, retinal pigment epithelial cells, and photoreceptors. The candidate will be expected to: conduct human imaging in healthy and diseased eyes, perform data processing, analysis and presentation, develop new and ...

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    21. University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives NIH Grant for Choroidal Disease Mechanisms in AMD

      University of Iowa Receives a 2019 NIH Grant for $381,250 for Choroidal Disease Mechanisms in AMD. The principal investigator is Elliott Sohn. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. We propose to investigate the pathophysiology of choroidal degeneration in age-related macular degeneration (AMD), the most common form of untreatable central vision loss in the western world. The choroid, the complex vascular system supplying the outer retina, photoreceptors, and retinal pigment epithelium (RPE), can now be visualized in living humans using enhanced depth imaging optical coherence tomography (OCT). Recent studies ...

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    22. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives NIH Grant  for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography.

      Northwestern University Receives a 2019 NIH Grant for $39,955 for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography. The principal investigator is Brian Soetikno. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The retina is one of the most metabolically active tissues in the human body, making it particularly susceptible to hypoxia. In diabetic retinopathy (DR), aberrant oxygen metabolism has been hypothesized to play a pivotal role its pathogenesis. An improved understanding of how imbalances in oxygen delivery and demand lead to the progression of DR ...

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    23. University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives NIH Grant for Understanding Otoacoustic Emissions

      University of Southern California Receives a 2019 NIH Grant for $487,053 for Understanding Otoacoustic Emissions. The principal investigator is Christopher Shera. The program began in 1999 and ends in 2024. Below is a summary of the proposed work. Realizing the potential of otoacoustic emissions (OAEs) as noninvasive probes of cochlear function requires understanding the physical and physiological mechanisms that generate and shape these sounds. To address important unresolved issues of cochlear mechanics while improving our understanding of OAE generation, we propose three aims involving innovative theoretical modeling rigorously tested by experimental measurements. The first Aim studies the action of ...

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    24. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives a 2019 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dyanamics. The principal investigator is Sueng Shen. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not ...

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