1. Optical Coherence Tomography News

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    1. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dynamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dynamics

      University of Washington Receives a 2020 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dynamics. The principal investigator is Tueng Shen. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not been a topic of major research interest. Topography, tonometry ...

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    2. Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives a 2020 NIH Grant for $188,771for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation. The principal investigator is Joseph Izatt. Below is a summary of the proposed work. This is an application for an Exploratory/Developmental Research Grant which brings together a team of experts in ophthalmic imaging, surgery and robotics to advance the state of the art in image-guided robotic microsurgical intervention. Corneal transplants are one of the most commonly performed allograft procedures worldwide, although there remains a substantial risk of immune rejection or graft failure. An alternative form of corneal transplantation ...

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    3. LighTopTech Corp. Receives Small Business Innovation Research Phase II Award from the US National Institutes of Health (NIH)

      LighTopTech Corp. Receives Small Business Innovation Research Phase II Award from the US National Institutes of Health (NIH)

      LighTopTech Corp., an upstate New York-based company building innovative optical instruments to bring to market disruptive imaging technologies industrial and medical fields, has been awarded a Phase II Small Business Innovation Research (SBIR) award by the National Eye Institute of the National Institutes of Health (NIH). The NIH Phase II award will allow LighTopTech to develop the first 3D high-definition imaging instrument based on Gabor-Domain Optical Coherence Microscopy (GDOCM) for quantitative assessment of corneal tissue at eye banks. LighTopTech will develop and apply machine learning methods to automatically segment the endothelial cells of the cornea and count them to assess ...

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    4. Research Assistant in Optical Coherence Tomography (OCT) to Image the Eye at University of Kent

      Research Assistant in Optical Coherence Tomography (OCT) to Image the Eye at University of Kent

      School of Physical Sciences Location: Canterbury Salary: £28,331 to £32,817 per annum Grade: Grade 6 Post Type: Full Time Contract Type: Fixed Term - Ends 31/03/2022 - to start as soon as possible Release Date: Wednesday 27 May 2020 Closing Date: 23.59 hours BST on Thursday 25 June 2020 (unless otherwise stated) Interview Date: To be confirmed Reference: STM-164-20 The School of Physical Sciences is seeking a motivated and organised Research Assistant, to work on a project which aims to tackle advancements of Optical Coherence Tomography (OCT) set-ups, applied to eye imaging. As a Research Assistant, working ...

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    5. Simon Poole, Cylite co-founder, elected as Fellow of Australian Academy of Science

      Simon Poole, Cylite co-founder, elected as Fellow of Australian Academy of Science

      Recognised for achievements in Photonics and his role in the development of an export-competitive photonics industry in Australia Melbourne, Australia, May 25, 2020 – Cylite Pty Ltd, a company developing the next generation of diagnostic OCT systems for Ophthalmology and Optometry, is delighted to announce Dr Simon Poole AO, one of Cylite’s co-founders and VP Business Development, has been elected as a Fellow of the Australian Academy of Science. Dr Poole is one of 24 new Fellows elected each year to the Academy. The citation for his election reads as follows: Simon Poole is an outstanding researcher and entrepreneur in ...

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      Mentions: Cylite
    6. PhD position on tunable lasers for optical coherence tomography at the University of Kent

      PhD position on tunable lasers for optical coherence tomography at the University of Kent

      We are recruiting for a PhD Studentship in the fields of Optics and Laser Physics, with emphasis on optical coherence tomography for a period of 36 months starting up to 31 January 2021, within the Applied Optics Group, School of Physical Sciences. This is supported by the Marie Curie Innovative Training Network scheme, 860807, EU funded, jointly organised with 14 other universities, companies and hospitals in Europe. You will spend time at the University of Kent and at the other beneficiaries or associated partners. Supervision will be provided in an European setting where specialized and complementary training will be provided ...

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    7. Perimeter Medical Imaging Receives $7.44 Million CPRIT Grant To Further Develop AI ImgAssist Technology at Leading Cancer Centers in Texas

      Perimeter Medical Imaging Receives $7.44 Million CPRIT Grant To Further Develop AI ImgAssist Technology at Leading Cancer Centers in Texas

      Perimeter Medical Imaging , a medical device company, today announces that it has received a $7.44 million grant from CPRIT, a leading state body funding cancer research, to continue developing its artificial intelligence technology that can help surgeons identify if cancer is still present post-tumor removal surgery. The sponsored technology, known as OTIS™, is designed to provide real-time information during breast cancer surgery. The platform’s ability to deliver ultra-high resolution and sub-surface image volumes across the surface of the removed tissue allows surgeons to assess if they have achieved the successful removal of the entire tumor. Should a surgeon ...

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    8. Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...

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    9. Doctoral Student in Optical Coherence Tomography at the Center for Medical Physics and Biomedical Engineering – Medical University of Vienna

      Doctoral Student in Optical Coherence Tomography at the Center for Medical Physics and Biomedical Engineering – Medical University of Vienna

      Position: PhD, Doctoral student in optical coherence tomography Location: Center for Medical Physics and Biomedical Engineering – Medical University of Vienna Description: The Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna has an immediate opening for PhD positions. The Center for Medical Physics and Biomedical Engineering is located in one of the largest European University hospitals (AKH Vienna) enabling multi-disciplinary innovative, vibrant science from bench to bedside. The research fields focus on the development, design, realization and application of novel biomedical optical imaging technologies (multimodal optical microscopy and endoscopy) as well as miniaturization of optical coherence ...

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    10. NinePoint Medical Receives NIH Grant for AI Computer Aided Diagnosis (CAD) Algorithm for Identification of Dysplasia in Patients with Barrett Esophagus

      NinePoint Medical Receives NIH Grant for AI Computer Aided Diagnosis (CAD) Algorithm for Identification of Dysplasia in Patients with Barrett Esophagus

      NinePoint Medical Receives a 2020 NIH Grant for $852,440 for AI Computer Aided Diagnosis (CAD) Algorithm for Identification of dysplasia in Patients with Barrett Esophagus. The principal investigator is Eman Namati. Below is a summary of the proposed work. The goal of this project is to develop a based computer aided diagnosis (CAD) algorithm for identification of regions at risk for developing esophageal adenocarcinoma (EAC) in optical coherence tomography (OCT) scans of the esophagus. EAC is one of the deadliest cancers with a 5-year survival rate of less than 20%; yet the standard of care for detecting precursors to ...

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    11. University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk

      University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk

      University of Pittsburg Receives a 2020 NIH Grant for $437,317 for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk. The principal investigator is Yang Liu. Below is a summary of the proposed work. The effectiveness of colorectal cancer (CRC) screening, with a concomitant increased emphasis on detection of even the smallest adenomas, has resulted in a new clinical challenge. An increased number of people are being identified as harboring an adenomatous polyp, the benign precursor to CRC. These patients are recommended to undergo surveillance, or repeated colonoscopy for monitoring for recurrence ...

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    12. Florida International University Receives NIH Grant for Imaging the Functional Biomarkers of Photoreceptors

      Florida International University Receives NIH Grant for Imaging the Functional Biomarkers of Photoreceptors

      Florida International University Receives a 2020 NIH Grant for $485,580 for Imaging the Functional Biomarkers of Photoreceptors. The principal investigator is Shuliang Jiao. Below is a summary of the proposed work. Vision is the most fundamental of our senses and it is perhaps the greatest tragedy of all when blindness robs us of this modality”. Photoreceptors are light-detecting cells initiating vision. Loss of photoreceptor leads to loss of vision. This happens in millions of Americans with hereditary retinal degenerations or age-related macular degeneration (AMD). Loss of vision is not only a personal tragedy but also a burden to the ...

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    13. Johns Hopkins University Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosi

      Johns Hopkins University Receives NIH Grant for Imaging Neurodegeneration in Multiple Sclerosi

      Johns Hopkins University Receives a 2020 NIH Grant for $585,102 for Imaging Neurodegeneration in Multiple Sclerosis. The principal investigator is Peter Calabresi. Below is a summary of the proposed work. One of the significant challenges facing treatment of people with multiple sclerosis (MS) is determining their individual likelihood of progression, as this information would significantly influence the type of therapy selected. Thus, developing specific tools to monitor and predict progression is critical to better manage patient care and to understand mechanisms of disease. We have been developing a multi-faceted approach to more readily monitor (through imaging) and predict (through ...

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    14. Postdoctoral Position in Optical Imaging and Image-Guided Surgery in Ophthalmology at Vanderbilt University

      Postdoctoral Position in Optical Imaging and Image-Guided Surgery in Ophthalmology at Vanderbilt University

      The Diagnostic Imaging and Image-Guided Interventions Lab (PI: Kenny Tao) at Vanderbilt University is seeking applicants for a postdoctoral position to develop novel technologies to visualize and quantify structural and functional changes in the retina during ophthalmic surgery. Previous system implementations included combinations of OCT and reflectance confocal imaging with machine-learning based tracking algorithms. Additional functionality to be integrated include OCT angiography, OCT elastography, and augmented-reality feedback. Quantifications: Applicants should have a Ph.D. in Electrical Engineering & Computer Science, Computer Engineering, or Biomedical Engineering and a strong background and publication record in optical engineering, electronics, and hardware design/translation. Previous ...

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    15. Postdoctoral Research Fellow In Ocular Imaging Program at the Singapore Eye Research Institute

      Postdoctoral Research Fellow In Ocular Imaging Program at the Singapore Eye Research Institute

      The Singapore Eye Research Institute (SERI) serves as Singapore’s national research institute for ophthalmic and vision research. SERI functions as the research arm of the various clinical ophthalmic centres in Singapore, including the Singapore National Eye Centre (SNEC), the national clinical centre for ophthalmology in Singapore. SERI has developed a world-leading reputation in broad-based clinical translational research programmes for eye diseases. Recently SERI has established an ocular imaging program together with Nanyang Technological University (NTU) under the directorship of Prof. Leopold Schmetterer. SERI is seeking a highly qualified individual to take on a significant role in this rapidly expanding ...

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    16. Indiana University Receives NIH Grant for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells

      Indiana University Receives NIH Grant for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells

      Indiana University Receives a 2020 NIH Grant for $409,668 for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells. The principal investigator is Donald Miller. Below is a summary of the proposed work. Ganglion cells (GCs) and other inner retinal neurons are fundamental to retinal neural circuitry, processing photoreceptor signals relayed from intermediate neurons for transmission to the brain. Yet, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. GCs in particular are lost to neurodegenerative disorders such as glaucoma, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We also know ...

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    17. University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging.

      University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging.

      University of Houston Receives a 2020 NIH Grant for $757,340 for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging. The principal investigator is David Mayerich. Below is a summary of the proposed work. The ability to correlate between large-scale developmental milestones and micro-scale cellular and protein- specific changes is a significant unmet need in the study of developmental biology. The overall objective of this work is to develop a multi-modality imaging platform that can provide time resolved three-dimensional images of tissue development, with high temporal and spatial resolutions at a molecular level. Current studies rely on ...

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    18. Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2020 NIH Grant for $483,246 for Novel Optical Diagnostics with Optical Coherence Tomography. The principal investigator is James Fujimoto. Below is a summary of the proposed work. T his proposal is a renewal of an ongoing collaborative program among investigators at the Massachusetts Institute of Technology (MIT) and New England Eye Center (NEEC). The program focuses on the development of optical coherence tomography (OCT) technology and its application to investigate structural alterations and blood flow impairment in age-related macular degeneration (AMD). Aim 1. Next Generation OCT Technology for Imaging Structure and Blood Flow ...

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    19. Yale University Receives a NIH Grant for Xenopus As A Model System for Hydrocephaly and Ependymal Ciliogenesis

      Yale University Receives a NIH Grant for Xenopus As A Model System for Hydrocephaly and Ependymal Ciliogenesis

      Yale University Receives a 2020 NIH Grant for $236,175 for Xenopus As A Model System for Hydrocephaly and Ependymal Ciliogenesis. The principal investigator is Engin Deniz. Below is a summary of the proposed work. Congenital Hydrocephalus (CH), the pathological expansion of the cerebral ventricles due to cerebrospinal fluid (CSF) accumulation, is a common birth defect (1 in every 1000 births) with high mortality and morbidity. In fact, CH is the most common disease treated by pediatric neurosurgeons and despite advances in surgical technique, palliation in many patients remains inadequate. In part, these challenging cases may be due to our ...

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    20. University of Minnesota Receives NIH Grant for Optical Imaging of Neural Activity Based on Lorentz Effect

      University of Minnesota Receives NIH Grant for Optical Imaging of Neural Activity Based on Lorentz Effect

      University of Minnesota Receives a 2020 NIH Grant for $275,000 for Optical Imaging of Neural Activity Based on Lorentz Effect. The principal investigator is Taner Akkin. Below is a summary of the proposed work. The development of label-free imaging technologies that directly assess neural activity remains a pressing need. Among a variety of techniques that aim to detect transient signals associated with action potential (AP) propagation, optical techniques have the potential for revealing and locating APs with high spatio- temporal resolution. For instance, differential-phase interferometry and then phase-sensitive measurements of spectral-domain optical coherence tomography (OCT) have allowed us to ...

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    21. Open Rank Tenure Track Faculty Position in Retina Research, University of Rochester, Rochester, NY

      Open Rank Tenure Track Faculty Position in Retina Research, University of Rochester, Rochester, NY

      Open Rank Tenure Track Faculty Position in Retina Research, University of Rochester, Rochester, NY The University of Rochester Flaum Eye Institute has a tenure-track position available for scientists working in retina research with a desire to utilize high resolution retinal imaging. A strategic goal of the Flaum Eye Institute is to develop and apply innovative new capabilities to study the structure and function of the retina in healthy and diseased eyes. This includes basic research on a number of animal model systems including (but not limited to) mouse and non-human primate systems. Research may also involve human imaging and the ...

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    22. Children's Hospital of Philadelphia Receives NIH Grant for Biomarkers of Vision Loss in Children with Optic Pathway Gliomas

      Children's Hospital of Philadelphia Receives NIH Grant for Biomarkers of Vision Loss in Children with Optic Pathway Gliomas

      Children's Hospital of Philadelphia Receives a 2020 NIH Grant for $611,652 for Biomarkers of Vision Loss in Children with Optic Pathway Gliomas. The principal investigator is Rogbert Avery. Below is a summary of the proposed work. Low-grade gliomas are the most common brain tumor in children and frequently involve the optic nerve, chiasm, and tract—so they are referred to as optic pathway gliomas (OPGs). OPGs cause vision loss, typically between 1 and 8 years of age, resulting in lifelong disability as well as reduced academic and vocational achievement. The long term goal of this research proposal is ...

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    23. Massachusetts Eye and Ear Infirmary Receives NIH Grant for Human Cochlear Structure & Function

      Massachusetts Eye and Ear Infirmary Receives NIH Grant for Human Cochlear Structure & Function

      Massachusetts Eye and Ear Infirmary Receives a 2020 NIH Grant for $544,982 for Human Cochlear Structure & Function. The principal investigator is Hideko Nakajima . Below is a summary of the proposed work. Although the inner workings of the cochlea are responsible for the most fundamental aspects of hearing, including hearing sensitivity and frequency tuning, our direct knowledge of human cochlear mechanics is limited. This lack of information has forced researchers to rely on animal experiments to make inferences about cochlear behavior in humans, under the assumption that the motions of the cochlear partition (CP), including the basilar membrane (BM) and ...

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    24. UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

      UIUC Receives NIH Grant for A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

      University of Illinois at Urbana-Champaign Receives a 2020 NIH Grant for $445,996 for A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD). The principal investigator is Liang Gao. Below is a summary of the proposed work. An imaging modality that allows for fast, simultaneous, noninvasive probing of both 3D cellular resolution retinal morphology by optical coherence tomography (OCT) and molecular-specific functions by autofluorescence (AF) could substantially improve both basic understanding and the early diagnosis of age- related macular degeneration (AMD), the leading cause of blindness in the developed world. The evaluation and management of ...

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