1. Optical Coherence Tomography News

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    1. Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral research fellowship immediately available at Yale on NIH funded T32 training grant focused on providing multi-disciplinary multi-modality training in molecular and translational cardiovascular imaging for highly qualified fellows holding either a MD or/and PhD, in preparation for academic careers as independent investigators in the highly clinically relevant field of cardiovascular imaging. Post-doctoral fellowship training will be 2-3 years in duration. There are three primary research focuses in the post-doctoral training, 1) cardiovascular molecular imaging, 2) cardiovascular imaging technologies and analyses, and 3) translational cardiovascular imaging. Applicants will have full access to resources available through the Yale Translational Research ...

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    2. Rowe Technical Design, Inc. announces that Whole Model Eye for OCT (Tissue Phantom) is now in production!

      Rowe Technical Design, Inc. announces that Whole Model Eye for OCT (Tissue Phantom) is now in production!

      Rowe Technical Design, Inc. (RTD), developers of the 1st commercial optical tissue phantom for OCT, announces that their latest version of the Whole Model Eye complete with Cornea, Crystalline Lens and Retina tissue phantoms for OCT has now been released for full serial production. “We’re excited because this is our third serial production model eye, following up on the very successful anterior chamber and OCT model eyes with retina tissue phantom” notes T. Scott Rowe, company founder and president. “We are extremely pleased with the customer feedback so far, and we are ready for serial production. This is the ...

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      Mentions: T. Scott Rowe
    3. University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.

      University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.

      The University of Alabama at Birmingham Receives a 2015 NIH Grant for $498,330 to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT. The principal investigator is Steven Mark Rowe. The program began in 2012 and elndsi nin 2016. Below is a summary of the proposed work. Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an anion transporter of chloride and bicarbonate. Defective or deficient CFTR leads to severe mucoobstructive lung disease and severe morbidity and early mortality due to lung infections. Even though substantial advances in ...

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    4. Perimeter Medical Imaging Closes Oversubscribed $5 Million Series A Financing Round Led By Roadmap Capital

      Perimeter Medical Imaging Closes Oversubscribed $5 Million Series A Financing Round Led By Roadmap Capital

      Perimeter Medical Imaging, Inc., a developer of real time imaging systems for in-surgery tissue assessment, is pleased to announce the closing of their $5 million Series A financing. The round was led by Roadmap Capital with participation from EPIC Capital, NorthView Ventures and Pathfinder Asset Management. Funds will support the completion of their current clinical study at Princess Margaret Cancer Centre as well as product development and FDA regulatory clearance for their first tissue imaging product. Perimeter’s ground-breaking new Optical Tissue Imaging System (OTIS™) is an intraoperative medical imaging tool that provides clinicians with the ability to visualize the ...

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    5. FedDev Ontario Supports Commercialization of Perimeter Medical Imaging’s OTIS™ Surgical Tissue Imaging System

      FedDev Ontario Supports Commercialization of Perimeter Medical Imaging’s OTIS™ Surgical Tissue Imaging System

      Perimeter Medical Imaging, Inc., a developer of real time imaging systems for in-surgery tumour margin assessment, today announced it is receiving up to $980,000 from the Government of Canada through the Federal Economic Development Agency for Southern Ontario (FedDev Ontario). The announcement was made at Perimeter’s new location in Toronto by John Carmichael, Member of Parliament for Don Valley West, on behalf of the Honourable Gary Goodyear, Minister of State for the Federal Economic Development Agency for Southern Ontario (FedDev Ontario). This investment will support the next phase of product and clinical development as well as accelerate regulatory ...

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    6. Case Western Reserve University Receives NIH Grant for Cardiac Radiofrequency Ablation Catheter with Integrated OCT Imaging

      Case Western Reserve University Receives NIH Grant for Cardiac Radiofrequency Ablation Catheter with Integrated OCT Imaging

      Case Western Reserve University Receives a 2015 NIH grant for $198,125 for Cardiac Radiofrequency Ablation Catheter with Integrated OCT Imaging. The principal investigator is Andrew Rollins. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. The long-term goal of this research program is to develop catheter-based optical coherence tomography (OCT) imaging tools that will improve the care of patients suffering from cardiac arrhythmias. This project aims to improve radiofrequency ablation (RFA) therapy, which is the standard of care for many arrhythmias, by providing microscopic image guidance at the tip of the ...

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    7. Johns Hopkins University Receives NIH Grant for Studying OCT to Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer.

      Johns Hopkins University Receives NIH Grant for Studying OCT to Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer.

      Johns Hopkins University Receives a 2015 NIH Grant for $48,120 for OCT to Distinguish B/T Tumor &Non-Tumor Tissue in Infiltrating Brain Cancer. The principal investigator is Carmen Kut. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. In brain cancers such as gliomas, aggressive removal of the solid tumor through surgery is associated with improved overall survival. In fact, i has been shown that at least 78% of the tumor has to be removed to make a meaningful difference in the patient's survival. Current techniques for tumor removal are ...

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    8. Serving unmet needs with OCT Webcast with Dr. Mark Brezinski

      Serving unmet needs with OCT Webcast with Dr. Mark Brezinski

      To view this webcast click HERE . This webcast was originally broadcast on July 16, 2015 and is now available for on demand viewing. What Steve Jobs referred to as “the unmet need” is a barrier to effective treatment, scientific discovery—and equipment sales. Traditionally, developers (engineers) strive for precision, elegance, and maximum theoretical performance (e.g. resolution), whereas the end user (physician or researcher) often has very different requirements. Unfortunately, efforts to bridge this gap can easily become confused. In this webcast, biophotonics pioneer Mark Brezinski MD explores unmet needs in biomedicine, using examples in OCT to illustrate how developers ...

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    9. Massachusetts General Hospital Receives NIH grant for the center for Biomedical OCT Research and Translation.

      Massachusetts General Hospital Receives  NIH grant for the center for Biomedical OCT Research and Translation.

      Massachusetts General Hospital Receives a 2015 NIH grant for $1,086,563 for the Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by ...

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    10. Stanford University Receives NIH Grant for Molecular Imaging of Protein Glycoslation in Living Subjects

      Stanford University Receives NIH Grant for Molecular Imaging of Protein Glycoslation in Living Subjects

      Stanford University Receives a 2015 NIH Grant For $392,576 for Molecular Imaging of Protein Glycoslation in Living Subjects. The principal investigator is Adam De La Zerda. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. The broad objective of this project is to develop instrumentation and chemistry imaging technologies to advance the study of protein glycosylation in living subjects. Protein glycosylation is the most abundant and complex posttranslational modification (PTM). Changes in protein glycosylation have been correlated with cancer progression, neurological disorders and many other diseases. Moreover, glycans are dynamic in ...

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    11. Stanford University Receives NIH Grant to Study Enhalnced Clinical Diagnosis of Early Osteoarthritis

      Stanford University Receives  NIH Grant  to Study Enhalnced Clinical Diagnosis of Early Osteoarthritis

      Stanford University Receives a 2015 NIH Grant for $461,667 to Study Enhalnced Clinical Diagnosis of Early Osteoarthritis. The principal investigator is Constance Chu. The program began in 2005 and ends in 2016. Below is a summary of the proposed work. Osteoarthritis is a leading cause of disability, and a major public health issue. Progressive loss of articular cartilage due to injury and degeneration are important etiological factors in the development of osteoarthritis. While laboratory studies show a potential to reverse pathological changes in articular cartilage prior to breakdown of the articular surface, a major barrier to clinical translation of ...

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    12. UIUC Receives a NIH Grant for a Partnership for Primary Care Imaging

      UIUC Receives a NIH Grant for a Partnership for Primary Care Imaging

      University of Illinois Urbana-Champaign Receives a 2015 NIH Grant for $925,920 for a Partnership for Primary Care Imaging. The principal investigaror is Stephen Boppart. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Primary Care Medicine, including Family Practice and Pediatrics, has traditionally relied on physical exam skills and simplistic instruments for critical diagnostic decision making, monitoring, and referral to medical specialists. The otoscope and ophthalmoscope are two historical and ubiquitous instruments that largely only illuminate and magnify tissue surfaces in the ear and eye, respectively. This Partnership will develop a ...

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    13. University of California Riverside Receives NIH Grant to Study Optical Detection of the Pre-Seizure State.

      University of California Riverside Receives NIH Grant to Study Optical Detection of the Pre-Seizure State.

      University of California Riverside received a 2015 NIH Grant for $441,942 to Study Optical Detection of the Pre-Seizure State. The principal investigator is Kevin Binder. The program began in 2013 and ends in 2016. Below is a summary of the proposed work. Reliable means of detecting changes which occur during the "pre-seizure state" could serve as a method of seizure prediction, a benchmark in epilepsy research (NIH Curing Epilepsy Conferences, 2000 and 2007). Our preliminary data indicate pre-seizure constriction in brain extracellular space (ECS) accompanied by reduction in near-infrared (NIR) optical scattering prior to detection of seizure by electroencephalography ...

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      Mentions: UC Riverside
    14. Feature Of The Week 7/6/2015: Ultra-Widefield Retinal MHz-OCT Imaging With up to 100 Degrees Viewing Angle

      Feature Of The Week 7/6/2015: Ultra-Widefield Retinal MHz-OCT Imaging With up to 100 Degrees Viewing Angle

      We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes and analyze the problems caused by the increased scan angle. Three imaging modes are tested: Single volume imaging with 85° FOV as well as with 100° and stitching of five 60° images to a 100° mosaic (measured as usually from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused ...

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    15. Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the Center for Ophthalmic Optics & Lasers, Oregon Health & Science University

      Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the Center for Ophthalmic Optics & Lasers, Oregon Health & Science University

      Postdoctoral research opportunities are available in the area of biomedical optics at the Center for Ophthalmic Optics & Lasers ( www.COOLLab.net ) in the Casey Eye Institute, Oregon Health & Science University (OHSU). The COOL laboratory is a multidisciplinary team that incorporates optical scientists, image processing experts, ophthalmologists, statisticians, managers, and technicians. The group collaborates with several institutions to develop novel OCT technology, develop diagnostic and surgical planning software, and conduct clinical trials. The laboratory is well supported by the National Institutes of Health ( http://www.octnews.org/articles/2920025/optical-coherence-tomography-used-500m-of-federall/ ) and industry, and has brought many novel diagnostic technology into clinical ...

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    16. St. Jude Medical Announces Launch of the First International Trial to Compare OCT-Guided Stent Implantation to IVUS or Angiography-Guided PCI

      St. Jude Medical Announces Launch of the First International Trial to Compare OCT-Guided Stent Implantation to IVUS or Angiography-Guided PCI

      St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the launch of the ILUMIEN III clinical trial, a prospective, international, randomized trial evaluating the clinical benefits of the company’s optical coherence tomography (OCT) guidance during stent implantation. The ILUMIEN III study will compare OCT-guided stent implantation to implantation guided by intravascular ultrasound (IVUS) or angiography alone, diagnostic tools that offer less resolution than OCT during intravascular assessments and percutaneous coronary intervention (PCI). The ILUMIEN III study is the largest multicenter randomized study to date to compare PCI outcomes associated with all three imaging tools. By ...

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    17. Optovue Introduces AngioVue OCTA in Glaucoma

      Optovue Introduces AngioVue OCTA in Glaucoma

      Optovue, a pioneer in optical coherence tomography angiography (OCTA) and leader in commercialization of the technology, announced that it has expanded the application of its OCT Angiography technology into glaucoma. After a successful introduction of the revolutionary AngioVue Imaging System to retina last year, Optovue has worked to develop clinical applications in glaucoma as well.

      The use of the AngioVue Imaging System in glaucoma was introduced at a highly successful symposium at the 6th World Glaucoma Congress in Hong Kong. The Optovue-hosted event featured presentations on the clinical applications of OCTA in glaucoma research using the company's AngioVue OCTA ...

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    18. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives NIH Grant  for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      The University of Illinois Urbana-Champaign Receives a 2015 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investigator is Stephen Boppart. The program begain in 2012 and ends in 2017. Below is a summary of the proosed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...

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    19. MGH Postdoctoral Research Fellowship (Optical Coherence Tomography)

      MGH Postdoctoral Research Fellowship (Optical Coherence Tomography)

      Postdoctoral Research Fellowship (Optical Coherence Tomography) Massachusetts General Hospital , Boston, MA, United States Employer Description The Wellman Center is driven by a focus on solving medical problems. We have assembled a multi-disciplinary faculty with expertise in the biological, physical and clinical sciences. By cultivating inter-disciplinary collaboration, we strive to span the research spectrum from basic biological studies through the development and testing of novel diagnostic and treatment technologies to their integration into mainstream clinical practice. Job Description A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital ...

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    20. Transformative clinical results with VivoSight in the diagnosis of Basal Cell Carcinoma: Data to be presented at the World Congress of Dermatology in Vancouver

      Transformative clinical results with VivoSight in the diagnosis of Basal Cell Carcinoma: Data to be presented at the World Congress of Dermatology in Vancouver

      Michelson Diagnostics, a medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that data showing significant improvement in the diagnosis of basal-cell carcinoma (BCC) using its VivoSight multibeam OCT scanner will be presented at the World Congress of Dermatology (Vancouver, June 8-13). In addition to being an efficient, non-invasive way to diagnose BCC and other non-melanoma skin cancers, using the VivoSight OCT scanner has the potential to reduce biopsies and surgery, thereby reducing scarring for patients. Joint lead investigator, Dr Martina Ulrich, CMB Collegium, Berlin, Germany, will outline the results of this independent multi-centre, prospective clinical ...

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    21. MGH Receives NIH Grant To Study Natural History of Barrett's Esophagus Using Capsule Endomicroscopy

      MGH Receives NIH Grant To Study Natural History of Barrett's Esophagus Using Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2015 NIH Grant for $472,417 To Study Natural History of Barrett's Esophagus Using Capsule Endomicroscopy. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. Barrett's esophagus (BE) is a condition where normal esophageal squamous mucosa changes to metaplastic columnar mucosa in response to chronic acid reflux. BE can progress to esophageal adenocarcinoma (EAC), a prevalent (~12,000 cases per year) and deadly cancer (~15% 5-year mortality rate). Current BE management strategies of anti-reflux therapy, endoscopic screening, and regular endoscopic biopsy surveillance and ablation therapy ...

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    22. MGH Receives a 2015 NIH Grant for Studying Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      MGH Receives a 2015 NIH Grant for Studying Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives a 2015 NIH Grant for $733,578 to Study Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function. The principal investigator is David Sosnovik. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. Pressure overload of the left and right ventricles initially leads to adaptive hypertrophy. This, however, is frequently followed by maladaptive hypertrophy, heart failure and death. We hypothesize here that changes in 3D myocardial fiber architecture play a significant role in the deleterious transition from adaptive to maladaptive hypertrophy and heart failure. We further hypothesize ...

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    23. Case Western University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western University Receives a 2015 NIH Grant for $359,023 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of altered ...

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    24. Stanford University Receives NIH Grant to study Molecular Imaging of Protein Glycoslation in Living Subjects

      Stanford University Receives NIH Grant to study Molecular Imaging of Protein Glycoslation in Living Subjects

      Stanford University Receives a 2015 NIH Grant for $392,576 to study Molecular Imaging of Protein Glycoslation in Living Subjects. The principal investigator is Adan De La Zerda. The program began in 2012 and ends in 2017. Below is a summary of the propose work. The broad objective of this project is to develop instrumentation and chemistry imaging technologies to advance the study of protein glycosylation in living subjects. Protein glycosylation is the most abundant and complex posttranslational modification (PTM). Changes in protein glycosylation have been correlated with cancer progression, neurological disorders and many other diseases. Moreover, glycans are dynamic ...

      Read Full Article
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