1. Optical Coherence Tomography News

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    1. Feature Of The Week 03/29/15: University of Washington Demonstrates In vivo Microvascular Imaging of Human Oral and Nasal Cavities using SS-OCT

      Feature Of The Week 03/29/15: University of Washington Demonstrates In vivo Microvascular Imaging of Human Oral and Nasal Cavities using SS-OCT

      Over decades, optical coherence tomography (OCT) has proven useful in the diagnosis of cavity disorders through in vivo feasibility or clinical studies in human. OCT studies have evaluated changes in cavity tissue morphology and optical properties of backscattered OCT signals from cavity tissue layers for the identification of abnormalities. Notwithstanding, there has been limited discussion regarding the assessment of microvasculature in human cavity tissues. The microcirculation within cavity tissues would be an invaluable indicator for assessing cavity disorders due to vascular malformation associated with disease progression. In this work, we report three-dimensional (3D) imaging of microcirculation within human cavity tissues ...

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    2. Optores Introduces OGOP – the Optores GPU OCT Processing Library

      Optores Introduces OGOP – the Optores GPU OCT Processing Library

      Optores proudly introduces OGOP – the Optores GPU OCT Processing library, an ultra-fast and highly reliable processing library for optical coherence tomography (OCT) data. Based on graphic-processing unit (GPU) optimized code, OGOP enables real-time OCT processing with sustained throughput of several gigabytes per second. The library can be licensed in editions with increasing feature sets and processing capabilities. It covers the whole OCT processing pipeline from raw data to image, and features future-proof cross-platform code. OGOP can been seen in action at Optores's new youtube channel . The video shows sustained and real-time volumetric OCT imaging with 20 entire volumes per ...

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    3. Feature Of The Week 03/22/15: Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens using a Co-Focused Ultrasound and Optical Coherence Elastography System

      Feature Of The Week 03/22/15: Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens using a Co-Focused Ultrasound and Optical Coherence Elastography System

      Presbyopia, the progressive, age-related loss of accommodation power of the eye, is closely related to the viscoelastic properties of the crystalline lens and their alterations by aging. The increase in lens stiffness is generally believed to be responsible for the progressive loss of the ability of the lens to change shape, leading to presbyopia. Noninvasive measurements of mechanical properties of the lens in vivo will promote the comprehensive understandings of the mechanism of accommodation and presbyopia, as well as help in developing new approaches for presbyopia treatment. In this work, we have studied the age-related changes in the biomechanical properties ...

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    4. Vertically Integrated Array-type Mirau-based Oct System for early detection of skin pathologies

      Vertically Integrated Array-type Mirau-based Oct System for early detection of skin pathologies

      VIAMOS proposes an OCT microsystem able to revolutionize the field of microscopes for dermatology imaging. The aim of the project is to develop a new generation of Optical Coherence Tomography micro-system in order to help the diagnosis of skin pathologies thanks to a three dimensional image. The challenge is to provide a hand-held, low-cost and fully parallel spectral domain OCT micro-device. The consequence is a significant upgrade by adding new features such as heterodyne detection and integrated swept source. The project leans on the experience of 8 highly recognized European research institutes and companies such as the FEMTO-ST, University of ...

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    5. Department of Biomedical Engineering Department Chair position at the University of California, Davis

      Department of Biomedical Engineering Department Chair position at the University of California, Davis

      The Department of Biomedical Engineering at the University of California, Davis, is seeking applications and nominations for the position of Department Chair. This is a senior level leadership position intended for candidates with an outstanding track record of research and professional accomplishments, leadership ability, dedication to education and commitment to faculty governance. The Department covers broad areas in Biomedical Engineering, both in teaching and research, with existing strengths in the areas of tissue engineering, cellular and molecular engineering, multi-scale biomechanics, biomedical imaging, therapeutics, micro- and nano-systems, and computational and systems biology, with an integrating theme of molecular and/or genetically ...

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      Mentions: UC Davis
    6. Compact Imaging Selected to Partner with Leading Irish Research Center to Further Develop Disruptive Technology

      Compact Imaging Selected to Partner with  Leading Irish Research Center to Further Develop Disruptive Technology

      Collaboration Will Miniaturize Breakthrough Optical Sensor For Mobile Health Monitoring, Biometric Security Silicon Valley-based Compact Imaging, Inc. today announced a technology collaboration with IPIC (Irish Photonic Integration Center), a Science Foundation Ireland (SFI) research center. The collaboration will provide IPIC’s world class technical expertise, specialized equipment and funding to enable Compact Imaging to transition its MRO™ optical sensor technology from bench-top prototypes to miniaturized low cost photonic modules suitable for integration with mobile devices and high volume production. Compact Imaging’s proprietary MRO™ (Multiple Reference Optical Coherence Tomography) technology is a highly disruptive tissue imaging and analysis system that ...

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    7. Wasatch Photonics Receives NIH SBIR for a Hand-Held Advanced Functional Imaging for Assessing Local Tissue Oxygenation

      Wasatch Photonics Receives NIH SBIR for a Hand-Held Advanced Functional Imaging for Assessing Local Tissue Oxygenation

      Wasatch Photonics Received a 2015 NIH SBIR for $149,950 for a Hand-Held Advanced Functional Imaging for Assessing Local Tissue Oxygenation. The principal investgator is Roman Kuranov. The program began in 2015 and ends in 2015. Below is a summary of the purposed work. We propose development of an advanced functional imager to assess red blood cell (RBC) transfusion. The prototype will be tested in a functional phantom during this SBIR Phase I project. The key features of the imager are the ability to quantify local tissue oxygenation with a handheld probe for easy tissue access. Our preliminarily market research ...

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    8. Florida International University Received a 2015 NIH Grant Multimodal Retinal Functional Imaging for Diabetic Retinopathy

      Florida International University Received a 2015 NIH Grant Multimodal Retinal Functional Imaging for Diabetic Retinopathy

      Florida International University Received a 2015 NIH Grant for $542,882 for Multimodal Retinal Functional Imaging for Diabetic Retinopathy. The principal investigator is Shuliang Jiao. The program begain in 2013 and ends in 2016. Below is a summary of the proposed work. Diabetic retinopathy (DR) is a leading cause of irreversible blindness among working-age adults, which is a typical type of ischemia driven retinal disease characterized by microvascular damage to the retina in patients with diabetes. DR progresses through a sequence of recognizable stages, which begin with structural and functional derangement of the retinal microcirculation even before the early clinical ...

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    9. Bioptigen Receives NIH Grant for Intrasurgical Optical Coherence Tomography

      Bioptigen Receives NIH Grant for Intrasurgical Optical Coherence Tomography

      Bioptigen Received a 2015 NIH Grant for $995,139 for Intrasurgical Optical Coherence Tomography. The principal investigator is Eric Buckland. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. Each year, over 20 million ophthalmic surgeries are performed worldwide. Indications for ophthalmic surgery include potentially blinding diseases, such as cataracts, diabetic retinopathy, macular disease, and retinal detachment. Surgeons performing these delicate procedures are challenged by the translucent nature of tissues in the eye, making it nearly impossible to visualize microstructural changes during surgery. Optical coherence tomography (OCT) is a non-contact, optical imaging ...

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    10. Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Endoscopic imaging technologies such as confocal laser endomicroscopy (CLE) and narrowband imaging (NBI) have been used to investigate vascular changes as hallmarks of early cancer in the GI tract. However, the limited frame rate and field of view make CLE imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high speed volumetric imaging of subsurface features at near-microscopic resolution, and can image microvasculature without exogenous contrast agents such as fluorescein, which obliterates the image in areas of bleeding, or after biopsies and resections. OCT has been ...

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    11. Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics

      Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics

      Columbia research team creating novel technology to improve diagnosis of peripheral arterial disease A comparison between a cross section of a foot in a healthy and a diabetic patient with peripheral artery disease. The optical tomographic imaging technology shows blood perfusion, or the absence of perfusion, in the issue. Approximately 8 to 12 million people in the United States alone are suffering from peripheral arterial disease (PAD) , a common vascular problem that is also one of the most serious complications of diabetes. Andreas Hielscher, professor of biomedical engineering, electrical engineering and radiology (physics) at Columbia Engineering, is developing a novel ...

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    12. Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      As part of the Erlangen Graduate School in Advanced Optical Technologies ( SAOT ) granted by the German Excellence Initiative for Cutting-Edge Research at Institutions of Higher Education, the research group of SAOT Juniorprofessor Maximilian Waldner invites applications for a Postdoc Position Research focus of the Lab/Research projects: The research group focuses on the implementation of new optical technologies for the diagnosis and treatment of gastrointestinal diseases. Current projects evaluate the potential of multiphoton microscopy, optical coherence tomography, hyper-spectral imaging techniques, Raman spectroscopy etc. in preclinical models of inflammatory diseases and cancer of the gastrointestinal tract. Prerequisites for the position are ...

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    13. Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye

      Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye

      The ARVO Special Interest Group meeting on "Optical Coherence Tomography Angiography of the Eye" wwill take place during ARVO 2015 meeting, in Denver Colorado. SIG Session Number: 125 Session Date/Start Time: M ay 3, 2015 from 1:30 PM to 3:00 PM Room: 2C/3C Mile High Ballroom Organizers: David Huang, Philip Rosenfeld, Moderators: Carmen Puliafito, James Fujimoto Participating in the Technology panel: David Huang, Yoshiaki Yasuno, Ruikang Wang, Yali Jia. Clinical panel 1: Phil Rosenfeld, SriniVas Sadda, Jay Duker, Ching-Jygh Chen, Bruno Lumbroso Clinical panel 2: Marco Rispoli, Andre Romano, Richard Rosen, Richard Spaide, Giovanni Staurenghi, Nadia ...

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    14. Feature Of The Week 03/01/15: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

      Feature Of The Week 03/01/15: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is an evolving imaging technology allowing non-destructive imaging of cartilage tissue at near-histological resolution. In this study, the diagnostic value of 3-D OCT in comparison to 2-D OCT in the comprehensive grading of human cartilage degeneration is investigated. In total, 53 human osteochondral samples were harvested. The imaging was performed by obtaining a single B-scan image (2-D OCT) and by collecting 100 consecutive B-scan images to generate a volumetric data set (3-D OCT). OCT images were assessed qualitatively according to a modified version of the DJD classification. OCT images were assessed quantitatively by algorithm-based evaluation of ...

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    15. NASA presents Heidelberg Engineering the NASA Certificate of Appreciation

      NASA presents Heidelberg Engineering the NASA Certificate of Appreciation

      Heidelberg Engineering was honored today by visitors from NASA. The guests from NASA: Dr. Christian Otto, Lead Scientist for the Vision Impairment and Intracranial Pressure (VIIP) project ; Dr. Steven Hart, lead flight surgeon for VIIP ; Rachel Brady, VIIP Science Coordinator; and Jennifer Villarreal, Project Manager came for a ceremony to present Heidelberg Engineering with the NASA Certificate of Appreciation in recognition of Heidelberg Engineering’s support in placing a SPECTRALIS ® OCT system on the International Space Station (ISS). During the ceremony, the NASA guests described the physiological challenges encountered with long duration space flight and the research underway to understand ...

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    16. Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser has now been developed for use in the treatment of atherosclerotic cardio-vascular disease. DWH Systems, Inc. of Seminole Florida working with ELAN Vascular Technologies has developed a system whereby three OCT imaging heads monitor a femtosecond ablation laser in real-time, to perform micro ablation on the outer surface of diseased arteries. OCT is used first to acquire a 3D, C-scan map of the diseased portion of an artery then develops an ablation map for the system to follow. As ablation is performed, OCT again monitors the lasers cutting process from multiple angles in ...

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    17. Feature Of The Week 02/22/15: Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      Feature Of The Week 02/22/15:  Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      The most commonly used method to analyze congenital heart defects involves serial sectioning and histology. However, this is often a time-consuming process where the quantification of cardiac defects can be difficult due to problems with accurate section registration. Here we demonstrate the advantages of using optical coherence tomography, a comparatively new and rising technology, to phenotype avian embryo hearts in a model of Fetal Alcohol Syndrome where a binge-like quantity of alcohol/ethanol was introduced at gastrulation. The rapid, consistent imaging protocols allowed for the immediate identification of cardiac anomalies, including ventricular septal defects and misaligned/missing vessels. Interventricular septum ...

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    18. University of Miami Receives NIH Grant for Advanced Imaging for Diabetic Retinopathy

      University of Miami Receives NIH Grant  for Advanced Imaging for Diabetic Retinopathy

      University of Miami Receives a 2015 NIH Grant for $155,387 for Advanced Imaging for Diabetic Retinopathy. The principal investigator is Delia Cabrera Debuc. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Diabetic retinopathy (DR) is a major cause of visual loss in diabetic individuals that presents a significant diagnostic challenge. Advances in preventing vision loss in these individuals are hindered by limited understanding of mechanisms underlying DR and the altered relationships between the retinal neural tissue and retinal vasculature. Therefore, an objective test for the early diagnosis and evaluation of ...

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    19. Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, is pleased to announce that it has closed the £2.5 million First Tranche of its Series B financing. This was led by strategic investor, global medical technology business Smith & Nephew and included new investor Kent County Council as well as existing investors. The £2.5 million investment will be used to expand the Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-centre clinical biopsy avoidance study and explore further applications of ...

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    20. Feature Of The Week 02/15/15: Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

      Feature Of The Week 02/15/15: Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

      Cystic fibrosis (CF) is a genetic disease that affects multiple organs due to the production of abnormally viscous mucus. Recurring pulmonary infections result in build-up of lung damage which leads to death. Intestinal, pancreatic, and hepatobiliary complications also occur, further aggravating the course of the disease. The molecular basis of CF is the dysfunction of the CF transmembrane conductance regulator (CFTR). CFTR-related disruption of transmembrane ion transport affects the exocrine glands, among which are the labial salivary glands (LSGs). Optical coherence tomography (OCT) enables non-invasive visualization of the internal structures of tissues at micrometer resolution in vivo and in real ...

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    21. Smith & Nephew bets on technology that 'sees through the skin'

      Smith & Nephew bets on technology that 'sees through the skin'

      Smith & Nephew has bet on a new technology that enables doctors to "see through the skin", in the hope that it could be used by the company's growing wound care business. The med tech giant has invested £1.25m in Michelson Diagnostics, a small Kent-based business which uses laser beams to produce high resolution images of cells beneath the surface of the skin. Michelson's Vivosight system is already being used in place of biopsies to diagnose non-melanoma skin cancer , a less aggressive but more common variety of the disease compared with more deadly melanoma skin cancers. But the ...

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    22. University of Washington Receives NIH Grant to Study Non-invasive Real-Time Label-Free 3D Imaging of Retinal Microcirculation.

      University of Washington Receives NIH Grant to Study Non-invasive Real-Time Label-Free 3D Imaging of Retinal Microcirculation.

      University of Washington Received a 2015 NIH Grant to Study Non-invasive real-time label-free 3D imaging of retinal microcirculation. The principal investigator is Ruikang Wang. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. Non-invasive and label-free imaging techniques for assessing retinal blood perfusion in humans - down to capillary-level resolution, are of paramount importance for improved understanding, diagnosis, treatment and management of diseases that have a vascular component in their pathogenesis, e.g., age related macular degeneration (AMD), diabetic retinopathy (DR), and open angle glaucoma (OAG). Invasive imaging techniques, e.g., fluorescein angiography ...

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    23. Medical College of Wisconsin Receives NIH Grant to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Receives NIH Grant  to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Received a 2015 NIH Grant for $317,475 to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins. The prinipal investigator is Laura Kreesty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in the US. Esophageal cancer is an extremely deadly malignancy with 5-year survival rates consistently under 20%. The precise reasons for increasing rates of EAC are an active area of investigation ...

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