1. Optical Coherence Tomography News

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    1. St. Jude Medical Announces Launch of OPTIS Integrated System

      St. Jude Medical Announces Launch of OPTIS Integrated System

      The OPTIS™ Integrated System combines OCT imaging with angiography to provide more detailed, on-demand coronary assessment for more accurate PCI guidanc e St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the company has secured CE Mark and FDA clearance for the new OPTISTM Integrated System. The system is a departure from traditional, mobile cart-based diagnostic tools and advances percutaneous coronary intervention (PCI) optimization via direct installation into a hospital’s cardiac catheterization laboratory, fully integrating optical coherence tomography (OCT) and fractional flow reserve (FFR) into PCI workflow. The approval of the OPTIS Integrated system marks ...

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    2. University of Texas at Arlington Receives NIH Grant to Study All Optical Control and Monitoring of Neural Activity.

      University of Texas at Arlington Receives NIH Grant to Study All Optical Control and Monitoring of Neural Activity.

      University of Texas at Arlington Received at 2014 NIH Grant for $206,065 to Study All Optical Control and Monitoring of Neural Activity. The principal investigator is Samarendra Mohanty. The program began in 2014 and ends in 2015. Below is a summary of the propose work. Success of optogenetic intervention of neural activity requires optimization of delivery of genes encoding light sensitive proteins (opsins) to specific cells, and to record the changes in cells and tissue during optogenetic stimulation. The most-commonly used method for delivering opsin(s) is use of viral vector, which is prone to cause unexpected inflammatory responses ...

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    3. New York University School of Medicine Receives 2014 NIH Grant to Study Hyperspectral Imaging of the Normal and Age-Related Macular Degeneration Fundus

      New York University School of Medicine Receives  2014 NIH Grant to Study Hyperspectral Imaging of the Normal and Age-Related Macular Degeneration Fundus

      A team with world-class expertise in ophthalmic disease, imaging, retinal pathology, and biomedical engineering will utilize hyperspectral imaging to provide, for the first time, in vivo molecular probing, validated with histopathologic correlation, of age-related macular degeneration (AMD). Their system, a specially modified fundus camera harnessed to cutting-edge biomedical image analysis techniques, will revolutionize the field by identifying the distribution and spectral signature of the various chromophores and fluorophores associated with AMD lesions. Drusen, the hallmark lesions of AMD, are biochemically heterogeneous and are key to understanding this disease. However, their composition cannot be determined in vivo with even the current ...

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    4. Feature Of The Week 9/14/14: UC Davis Investigates Brain Imaging with Optical Coherence Tomography

      Feature Of The Week 9/14/14: UC Davis Investigates Brain Imaging with Optical Coherence Tomography

      One of the nine high priority research areas in the recent BRAIN Initiative (executive summary available at HERE ) is to “Delineate mechanisms underlying human brain imaging technologies.” While empowering tools such as two-photon microscopy, used in conjunction with dyes and indicators, can image cellular and vascular activity, even measuring activity in all cells and vessels comprising a single voxel in a functional magnetic resonance imaging (fMRI) scanner remains a daunting task. Hence, mesoscopic imaging tools are needed to help bridge the gap between microscopic and macroscopic (human brain level) findings. Here, using Optical Coherence Tomography angiography at 1300 nm, we ...

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    5. Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology

      Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology

      Bioptigen announced today the availability of a newly developed deep imaging OCT system for the optical device metrology and pre-clinical ophthalmic research markets. The Envisu S4410 SDOCT for Contact Lens Metrology is designed for non-destructive, non-contact, full immersion measurements for standard and high complexity contact lens, IOL structures, and donor tissues. The metrology system allows imaging of a complete contact lens immersed in a hydration bath (saline), automated segmentation of anterior and posterior surfaces, and quantification of curvatures across both surfaces. The system delivers 5 um axial pixel resolution, 11 mm scan depth in saline, and a full 20mm lateral ...

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      Mentions: Bioptigen
    6. Tornado Spectral Systems Announces Investment by Beauvest & Roadmap Captial

      Tornado Spectral Systems Announces Investment by Beauvest & Roadmap Captial

      Strategic Growth Round to Accelerate Global Expansion of Process Analyzers and Spectrometers-On-Chip Tornado Spectral Systems Inc., an emerging tech company developing radically superior tools for measuring the chemical composition and structure of materials in real-time for a variety of demanding industrial processes, announced additional funding led by venture capital firms BeauVest and Roadmap Capital. The new investments will be used to finance Tornado’s continued growth in North America and globally. With proprietary optical and nanophotonic technologies that overcome the limitations of conventional spectroscopy-based analyzers, Tornado Spectral Systems has developed a new class of instruments that can acquire chemical signatures ...

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    7. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomgoraphy for Glaucoma

      Oregon Health & Science University Receives NIH Grant  for Functional and Structural Optical Coherence Tomgoraphy for Glaucoma

      Oregon Health & Science University Receives a 2014 NIH Grant for $734,129 for Functional and Structural Optical Coherence Tomgoraphy for Glaucoma. The principal investigator is David Huang. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnosis and close monitoring of glaucoma are important because the onset is insidious and the damage is irreversible. Advanced imaging modalities such as optical coherence tomography (OCT) have been used in the past 2 decades to improve the objective evaluation of glaucoma. OCT has higher axial spatial resolution ...

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    8. Oregon Health & Science University Receives 2014 NIH Guiding The Treatment of Anterior Eye Disease with Optical Coherence Tomography

      Oregon Health & Science University Receives 2014 NIH  Guiding The Treatment of Anterior Eye Disease with Optical Coherence Tomography

      Oregon Health & Science University Receives a 2014 NIH Grant for $713,409 for Guiding The Treatment of Anterior Eye Disease with Optical Coherence Tomography. The principal investigator is David Huang. The program began in 2007 and ends in 2016. Below is a summary of the proposed work. Optical coherence tomography (OCT) is a cross-sectional and 3-dimensional (3-D) imaging technology with very fine spatial resolution (5 um). This project develops the methods and software needed for high-precision OCT measurements of the eye to guide implant, laser, and transplant surgeries in the front part of the eye. In the proposed continuation of ...

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    9. Stanford University Receives Grant for Molecular Imaging of Protein Glycosylation in Living Subjects

      Stanford University Receives Grant for Molecular Imaging of Protein Glycosylation in Living Subjects

      Stanford University Receives 2014 NIH Grant for $392,576 for Molecular Imaging of Protein Glycosylation in Living Subjects. The principal investigator is Adam De La Zerda. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. The broad objective of this project is to develop instrumentation and chemistry imaging technologies to advance the study of protein glycosylation in living subjects. Protein glycosylation is the most abundant and complex posttranslational modification (PTM). Changes in protein glycosylation have been correlated with cancer progression, neurological disorders and many other diseases. Moreover, glycans are dynamic in time ...

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    10. Bioptigen Receives NIH Grant for Measuring Choroidal Blood Flow Imaging with Spectral Domain OCT

      Bioptigen Receives NIH Grant  for Measuring Choroidal Blood Flow Imaging with Spectral Domain OCT

      Bioptigen Receives 2014 NIH Grant for $223,583 for Measuring Choroidal Blood Flow Imaging with Spectral Domain OCT. The principal investigator is Eric Buckland. The program began in 2014 and ends in 2015. Below is a summary of the proposed work. Ophthalmic vascular diseases impact millions of Americans. Age-related macular degeneration and diabetic retinopathy are the two major diseases with a well- known vascular factor. The role of the vascular system in glaucoma and retinopathy of prematurity is more insidious. The vascular theory of glaucoma suggests that the blood supply to the eye is a contributory factor in glaucoma. Advanced ...

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    11. Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives NIH Grant  for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives a 2014 NIH Grant for $681,519 for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo. The principal investigator is Robert Brown. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. This Biomedical Research Partnership (BRP) proposal involves a partnership among a biomedical engineering team, a pulmonary physiology team, and a clinical pulmonary medicine team. This research program will incorporate state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human obstructive lung diseases (OLD). Optical coherence tomography (OCT) is ...

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    12. Postdoctoral and PhD-student positions at Utsunomiya University, Japan

      Postdoctoral and PhD-student positions at Utsunomiya University, Japan

      PhD graduates with experience in retinal imaging, adaptive optics or polarization are invited to apply for a postdoctoral position. PhD positions are available for MSc students with a degree in optics, applied physics, computer science or electrical engineering. We also regularly have students and postdocs visit for a short-term internship (3 months, 6 months, etc). Please inquire if you are interested in an internship. Our goal is to build practical OCT instrumentation for the early detection of retinal diseases such as glaucoma and age related macular degeneration. To achieve this goal, we are using optical technologies: optical coherence tomography, polarization ...

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      Mentions: Barry Cense
    13. Post-Doc Position for biomedical engineer / vision scientist in small animal High-Resolution Retinal Imaging Group at University of California, Davis

      Post-Doc Position for biomedical engineer / vision scientist in small animal High-Resolution Retinal Imaging Group at University of California, Davis

      Applications are invited for a post-doctoral research associate position in the UC Davis EyePod Small Animal Imaging Laboratory in the Department of Cell Biology and Human Anatomy at the UC Davis Main Campus. The goal of our research is to develop the next generation in vivo small animal cellular resolution multimodal retinal imaging instruments to study age-related changes in vision and retinal disorders. The ideal candidate will have strong skills in some combination of retinal/microscopic imaging modalities, including but not limited to adaptive optics (AO), OCT, SLO, multispectral imaging, fluorescence, etc. Knowledge of programming languages (e.g. C++, LabView ...

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    14. Children's Research Institute Receives NIH Grant to Study Visual Outcome Measures in Children with Optic Pathway Gliomas

      Children's Research Institute Receives NIH Grant  to Study Visual Outcome Measures in Children with Optic Pathway Gliomas

      Children's Research Institute Received a 2014 NIH Grant for $229,113 to Study Visual Outcome Measures in Children with Optic Pathway Gliomas. The principal investigator is Robert Avery. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. This Mentored Patient-Oriented Research Career Development Award will prepare a pediatric neuroophthalmologist for an academic career as an independent multidisciplinary clinical researcher with a focus on vision outcomes in children with brain tumors of the visual pathway called optic pathway gliomas (OPGs). The candidate's application provides training needed to establish a clinical research ...

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    15. Second International Symposium on Optical Coherence Tomography for Non-Destructive Testing March 25th, 2015

      Second International Symposium on Optical Coherence Tomography for Non-Destructive Testing March 25th, 2015

      Optical Coherence Tomography (OCT) is a well-qualified tool for contactless, structural imaging of various samples. Already well-established in medical applications, in the last years the usage of OCT has been extended to diverse fields of non-destructive testing as well. In course of this progress, various devices for industrial measurements, process monitoring and research were developed. With our invitation to the second international symposium on Optical Coherence Tomography for Non-Destructive Testing OCT4NDT we like to settle a tradition from the well-founded forum for the OCT community. The symposium is intended to serve as a platform enabling an exchange of information on ...

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      Mentions: RECENDT
    16. Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      In current study, we fully integrated near-infrared fluorescence (NIRF) molecular imaging into intravascular OCT structural imaging. The OCT/NIRF single catheter imaging clearly demonstrated the microstructure of atheromata and simultaneously identified ICG-enhancing macrophage abundant lipid-rich areas of the plaques. Ex vivo NIRF imaging evidently validated in vivo OCT-NIRF imaging. NIRF signals on ex vivo fluorescence reflectance imaging colocalized well with in vivo NIRF imaging. In vitro ICG cell uptake, correlative fluorescence microscopy, and histopathology corroborated the in vivo imaging findings. Herein, our research team have solved the issues critical for application of this OCT/NIRF imaging technology to clinical practice ...

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    17. Software Postdoctoral Position in Optical imaging at Casey Eye Institute, Oregon Health & Science University

      Software Postdoctoral Position in Optical imaging at Casey Eye Institute, Oregon Health & Science University

      The Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University, is seeking outstanding candidates for the following position in optical imaging research in the field of ophthalmology. Post-Doc (software): optical signal processing, image processing Requirements: PhD degree in a relevant discipline (Biomedical Engineering, Medical Physics, computer science, applied mathematics) is required. Solid background in optical signal processing, (medical) image analysis, segmentation and/or image registration are essential. Experiences in imaging (scanning laser ophthalmoscopy, angiography, microscopy, oximetry, adaptive optics), and software development (GPU programming) are also desirable. The successful candidate will be supervised by ...

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    18. This is Your Brain's Blood Vessels on Cocaine

      This is Your Brain's Blood Vessels on Cocaine

      New imaging technique shows how cocaine shuts down blood flow in mouse brains A new method for measuring and imaging how quickly blood flows in the brain could help doctors and researchers better understand how drug abuse affects the brain, which may aid in improving brain-cancer surgery and tissue engineering, and lead to better treatment options for recovering drug addicts. The new method, developed by a team of researchers from Stony Brook University in New York, USA and the U.S. National Institutes of Health, was published today in The Optical Society’s ( OSA ) open-access journal Biomedical Optics Express . The ...

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    19. University of Arizona Receives NIH Grant for Translational Studies and Clinical Pharmacology of New Drugs for Chemoprevention

      University of Arizona Receives NIH Grant for Translational Studies and Clinical Pharmacology of New Drugs for Chemoprevention

      University of Arizona Receives a 2014 NIH Grant for $294,662 for Translational Studies and Clinical Pharmacology of New Drugs for Chemoprevention. The principal investigator is Steven Stratton The program began in 2014 and ends in 2015 Below is a summary of the proposed work. Project 3 will test and clinically validate mechanisms and pharmacologic strategies explored in Projects 1-2, which target Akt-mTOR, AMPK-mTOR, and Fyn/RSK pathways. Advanced clinical/translational study of skin cancer carcinogenesis, biology, and pathophysiology will help reduce morbidity/ mortality, provide insight into keratinocyte signaling, and provide an easily-accessed human model of full-spectrum carcinogenesis for other ...

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    20. Columbia University Receives NIH Grant for Measures Of Human Receptor and Post Receptor Activity

      Columbia University Receives NIH Grant for Measures Of Human Receptor and Post Receptor Activity

      Columbia University Receives 2014 NIH Grant for $532,143 for Measures Of Human Receptor and Post Receptor Activity. The principal investigator is Donald Hood. The program began in 1991 and ends in 2016. Below is a summary of the proposed work. Our long-term objective has been to develop a set of noninvasive techniques for studying the human retina. By applying novel techniques and current theories of phototransduction to the full-field electroretinogram (ERG), we have successfully developed widely-used noninvasive techniques for studying the global activity of the rod and cone receptors, as well as the rod bipolar cells. These indices of ...

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    21. University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas

      University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas

      University of Washington Received a 2014 NIH Grant For $232,550 for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...

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    22. UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California at Irvine Received a 2014 NIH Grant for $598,705 for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging. The principal investigator is Zhongping Chen. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution ...

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    23. Postdoctoral Research Associate at University of Liverpool

      Postdoctoral Research Associate at University of Liverpool

      £31,644 - £36,661 pa Faculty of Science and Engineering, Institute of Electrical Engineering and Electronics, Department of Electrical Engineering and Electronics Location: University Campus Ref: R-585803/WWW Closing date for receipt of applications: Fri, 22 Aug 2014 17:00:00 BST To undertake a project “ I ntelligent Manufacturing of Pharmaceutical Film Coating Using Terahertz Pulsed Imaging, Optical Coherence Tomography and Numerical Modelling ” in collaboration with Cambridge University. You will primarily focus on the development and integration of an optical coherence tomography (OCT) sensor for online monitoring and quality control of pharmaceutical coating process. The duties include OCT sensor instrumentation ...

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    24. Postdoctoral Opening at Biophotonics Laboratory at Yale University

      Postdoctoral Opening at Biophotonics Laboratory at Yale University

      There is an immediate opening at Yale University for a postdoctoral associate to work on a newly-funded research project entitled “Massively parallel interferometric confocal microscopy using degenerate lasers.” The postdoctoral associate will be supervised by Michael A. Choma, MD, PhD (Yale Diagnostic Radiology) in collaboration with Hui Cao, PhD (Yale Applied Physics). The postdoctoral associate will work in a highly collaborative and interdisciplinary environment to develop next-generation laser technologies to enable new kinds of biomedical optical imaging systems. We are particularly interested in candidates who have experience in designing and building solid-state lasers, but candidates with excellent skills in designing ...

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