1. Optical Coherence Tomography News

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    1. Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing

      Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing

      Perimeter Medical Imaging, Inc., the leader in real-time tissue imaging in the operating suite is pleased to announce the completion of a pre-public financing round raising $C4.4million. Perimeter intends to go public via a reverse takeover (RTO) with New World Resources (NW) in Q4 of this year. Funds raised in this pre-public round and anticipated RTO will support the commercialization of Perimeter's U.S. Food and Drug Administration (FDA) cleared OTISTM medical imaging technology. OTISTM is deployed in the surgical suite, empowering surgeons with real-time tissue imaging to help optimize cancer surgery outcomes. "We are pleased to have ...

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    2. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2019 NIH Grant for $1,230,507 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease .The principal investigator is Danny Wang. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are inaccessible to existing imaging technologies. Characteristic parenchymal lesions on ...

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    3. Columbia University Receives NIH Grant for Measures of Human Receptor and post Receptor Activity

      Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity

      Columbia University Receives a 2019 NIH Grant for $636,552 for Measures of Human Receptor and post Receptor Activity. The principal investigator is Donald Hood. Below is a summary of the proposed work. Our long-term objective has been to develop noninvasive techniques for studying the human retina for both basic science and clinical purposes. By applying current theories of phototransduction to the full-field electroretinogram (ERG), we successfully developed widely used techniques for studying the global activity of the rod and cone receptors, as well as the rod bipolar cells. These indices of objective retinal function are appropriate outcome measures for ...

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    4. Avinger Announces Presentations by Key Opinion Leaders at AMP 2019 Clinical Conference

      Avinger Announces Presentations by Key Opinion Leaders at AMP 2019 Clinical Conference

      Avinger, Inc. (NASDAQ: AVGR ), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for the diagnosis and treatment of Peripheral Artery Disease (PAD), today announced four podium presentations featuring the Company’s Lumivascular technology at the annual AMP (Amputation Prevention Symposium) conference occurring last week. Key opinion leaders in the fields of interventional cardiology highlighted Avinger ’s Lumivascular technology, which includes the Pantheris family of image-guided atherectomy products and the Ocelot family of image-guided chronic total occlusion (CTO) crossing products, in the following sessions: Dr. Thomas Davis, an interventional cardiologist at Eastlake Cardiovascular and one ...

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      Mentions: Avinger
    5. Senior Manufacturing Engineer(ing) Opening Conavi

      Senior Manufacturing Engineer(ing) Opening Conavi

      See your future at Conavi! Join our collaborative and entrepreneurial team designing and manufacturing minimally invasive innovative imaging solutions to improve cardiac care around the world. Conavi Medical’s Foresight ICE catheter is the world's first intracardiac echo system with the capability to acquire 2D and 3D images with a broad field-of-view that includes both side-viewing and forward-looking capabilities. Our Novasight Hybrid System enables simultaneous imaging of coronary arteries with both intravascular ultrasound (IVUS) and Optical Coherence Tomography (OCT). If you would like to be a part of our growing and talented team that is making a difference in ...

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    6. Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory

      Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory

      Immediate opening at Duke University Biomedical Engineering Department for a postdoc interested in interdisciplinary applications of image analysis and computer vision with emphasis on optical coherence tomography image analysis. Postdoc will be supervised by Prof. Sina Farsiu ( http://people.duke.edu/~sf59/ ). The candidate must have a demonstrated strong background in image processing as evidenced by publication of papers in high-impact peer-reviewed journals. Programming skill in MATLAB/Python is required. PhD in EE, BME, or CS. Prior experience in ophthalmic sciences, optical coherence tomography, adaptive optics is a plus but not necessary. Projects can be chosen based on the interests ...

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    7. University of Alabama Receives NIH Grant for Clinical and Translational Core.

      University of Alabama Receives NIH Grant  for Clinical and Translational Core.

      University of Alabama Receives a 2019 NIH Grant for $225,529 for Clinical and Translational Core. The principal investigator is Steven Rowe. Below is a summary of the proposed work. Experimental techniques that require measurements in cystic fibrosis (CF) patients and tissues have demonstrated clear utility in CF science. Such capabilities have enabled advances including important contributions to our understanding of basic aspects of disease pathogenesis, characterization of novel therapeutics directed towards CF ion transport defects, and the evaluation of CFTR modulators in human subjects. The purpose of Core C is to provide resources, expertise, and support to a wide ...

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    8. University of Alabama Receives NIH Grant for Cell Model Evaluation Core.

      University of Alabama Receives NIH Grant for Cell Model Evaluation Core.

      University of Alabama Receives a 2019 NIH Grant for $241,719 for Cell Model Evaluation Core. The principal investigator is Bradford Woodworth. Below is a summary of the proposed work. A Well-differentiated primary human airway epithelial cells and the assays that can be used with them are an instrumental model for understanding epithelial biology and are highly predictive of in vivo results in clinical trials. Primary cells can be used with methodologies that translate readily to assays of airway function in vivo, including measures of CFTR activity or other ion transporters, airway surface liquid depth and mucus hydration, and mucus ...

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    9. NinePoint Medical Announces FDA Clearance for Pancreatic and Biliary Applications of the NvisionVLE® Imaging System

      NinePoint Medical Announces FDA Clearance for Pancreatic and Biliary Applications of the NvisionVLE® Imaging System

      NinePoint Medical, Inc ., a transformative medical device company pioneering the use of a real-time optical imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) clearance to market the NvisionVLE® Imaging System for use in the pancreas and bile duct. These anatomical indications add to the previously existing esophageal applications for NinePoint’s state-of-the-art Optical Coherence Tomography (OCT) imaging platform. The NvisionVLE Imaging System provides physicians real-time, high-resolution volumetric images of the tissue surface and subsurface. This allows gastroenterologists to thoroughly evaluate tissue for regions of interest that may not be visible ...

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    10. Doheny Eye Institute Receives NIH Grant for Discovery and Validation of AMD Biomarkers for Progression Using Deep Learning

      Doheny Eye Institute Receives NIH Grant for Discovery and Validation of AMD Biomarkers for Progression Using Deep Learning

      Doheny Eye Institute Receives a 2019 NIH Grant for $235,500 for Discovery and Validation of AMD Biomarkers for Progression Using Deep Learning. The principal investigator is Zhihong Hu. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is the leading cause of blindness among elderly individuals. Currently there are no proven effective therapies for treatment of advanced non-neovascular AMD, termed geographic atrophy (GA). Earlier intervention may be preferable, but this would require identification of those individuals with the highest risk for progression to atrophy. Over the last two decades, various studies including ours have identified several ...

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      Mentions: UCSF Zhihong Hu
    11. Massachusetts General Hospital Receives NIH Grant for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant  for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $179,280 for Low Risk In Vivo Diagnosis of IPF with Optical Imaging. The principal investigator is Lida Hariri. Below is a summary of the proposed work. Idiopathic pulmonary fibrosis (IPF) is a progressive, ultimately fatal form of idiopathic interstitial pneumonitis (IIP), with a 3 year survival rate of 0%. Diagnostic certainty of IPF is critical to patient management and therapeutic decision-making. Two new FDA-approved therapies, pirfenidone and nintedanib, have been shown to slow disease progression in IPF and brought new hope to IPF patients. Due to their high costs, side ...

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    12. Indiana University Receives NIH Grant for Objective Outcome Measure for clinical Assessment of Erosive Tooth Wear

      Indiana University Receives NIH Grant for Objective Outcome Measure for clinical Assessment of Erosive Tooth Wear

      Indiana University Receives a 2019 NIH Grant for $198,747 for Objective Outcome Measure for clinical Assessment of Erosive Tooth Wear. The principal investigator is Anderson Hara. Below is a summary of the proposed work. Erosive tooth wear (ETW) is a multifactorial and cumulative condition of growing prevalence that leads to substantial loss of dental structure, resulting in pain and harm to dental function and esthetics. Specifically in the USA, it affects approximately 46% of teenagers and 80% of adults. Despite these alarming numbers, USA dental professionals are largely unaware of this condition, and specific diagnostic set rules and management ...

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    13. Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2019 NIH Grant for $186,711 for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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    14. Altris AI algorithm for retinal conditions detection on Optical Coherence Tomography (OCT) scans gets European CE-mark certification

      Altris AI algorithm for retinal conditions detection on Optical Coherence Tomography (OCT) scans gets European CE-mark certification

      Altris AI (Altris, Inc), a global artificial intelligence (AI) healthcare company, announced that it has received the CE Mark approval for its Standard Functionality for retinal conditions detection on Optical Coherence Tomography (OCT) scans. Altris AI Standard Functionality is ready for preliminary screening of retinal diseases in clinical practice. Altris AI detects retinal pathological signs of more than 30 retinal diseases and classifies them according to severities. Altris AI Standard Functionality for OCT scans interpretation, the first of multiple Altris AI versions, is now approved for commercial sale within the European Union. Altris AI diagnostic software is based on computer ...

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      Mentions: Altris AI Huvitz
    15. Avinger Announces Pantheris SV Limited Launch and Successful Treatment of First Patients in the United States

      Avinger Announces Pantheris SV Limited Launch and Successful Treatment of First Patients in the United States

      Avinger, Inc. ( Nasdaq: AVGR ), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced that physicians in four U.S. sites have successfully treated several patients with the Pantheris SV (Small Vessel) image-guided atherectomy system. These initial cases are part of a limited launch at up to 13 leading clinical centers prior to expanding commercial distribution to additional treatment facilities in the U.S. Pantheris SV, a product line extension of Avinger’s onboard image-guided atherectomy platform, expands Avinger’s portfolio of atherectomy devices for ...

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      Mentions: Avinger
    16. PhD Position on Biomedical Optics, Vrije University Amsterdam

      PhD Position on Biomedical Optics, Vrije University Amsterdam

      JOB DESCRIPTION Due to ageing, the impact of vision threatening diseases such as diabetic retinopathy (DR) and age-related macular degeneration ( AMD ) on the health care system will only increase. In this project we will develop techniques to quantitatively assess the oxygen saturation status of the retinal microvasculature. Reduced blood oxygen levels may lead to hypoxia, which is one of the key drivers of the formation of new blood vessels. These new blood vessels are often leaky, which leads to complications such as vision loss and, ultimately, to blindness. The development of techniques to detect the onset of retinal hypoxia will ...

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    17. Feature Of The Week 07/22/2019: Tsinghua University Demonstrates A “Sparse Sampled” Smart CCD Camera for Compressed Sensing Optical Coherence Tomography.

      Feature Of The Week 07/22/2019: Tsinghua University Demonstrates A “Sparse Sampled” Smart CCD Camera for Compressed Sensing Optical Coherence Tomography.

      Optical coherence tomography (OCT) is a promising imaging technique in medicine and biology, which allows for obtaining high-resolution, cross-sectional images of biological tissues. In the past decade, the imaging speed of OCT is consistently increasing, and currently OCT can acquire three-dimensional (3D) images in real time with imaging speed up to 10-MHz A-scan rate. With such a high imaging rate, OCT system has to acquire a large amount of data, which is too massive for data transmission and storage. Compressed sensing (CS) technique is a powerful method to solve this problem. It exploits the sparsity property of the signal and ...

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    18. Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex

      Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex

      Massachusetts General Hospital Receives a 2019 NIH Grant for $463,473 for Multimodal Mapping of the Neurocircuitry of the Human Prefrontal Cortex. The principal investigator is Anastasia Yendiki. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The objective of the proposed research is to map the organization of human white matter (WM) with cutting-edge ex vivo imaging technologies. This work will produce microscopic-level information on several long-range WM projections, as well as a more targeted mapping of circuits that serve the prefrontal cortex (PFC). These circuits are of particular interest in ...

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    19. Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives a 2019 NIH Grant for $300,000 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy ...

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    20. Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT

      Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT

      Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable Vertical Cavity Surface Emitting Lasers for Low-Cost Ophthalmic Swept Source Optical Coherence Tomography. The principal investigator is Christopher Burgner. The program began in 2012 and ends in 2020. Below is a summary of the proposed work. The ultimate goal of this effort is to bring advanced ophthalmic swept source optical coherence tomography (SS-OCT) imaging to low cost broadly accessible environments. SS-OCT is a powerful non-invasive diagnostic imaging modality, and an increasingly valuable tool in the early detection and monitoring of a number ...

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    21. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives a 2019 NIH Grant for $299,221 for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes. The principal investigator is Jennifer Barton. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional ...

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    22. 7th International Meeting on OCT Angiography and Advances in Imaging will be organized by Bruno Lumbroso M.D. in Rome December 13 and 14, 2019

      7th International Meeting on OCT Angiography and Advances in Imaging will be organized by Bruno Lumbroso M.D. in Rome December 13 and 14, 2019

      The 7 th International Meeting on OCT Angiography and Advances in Imaging will be organized by Bruno Lumbroso M.D. in Rome December 13 and 14, 2019. The meeting will present 75 sessions and 330 papers on clinical scientific and technological topics of OCT, OCT Angiography and other ocular imaging techniques, vascular anatomy and physiology. Latest progresses in OCT, OCT angiography, Wide angle retinography, Artificial Intelligence in Ocular Imaging will be underlined. The role of ocular circulation in chorio capillaris, choroid, retina, optic nerve will be given specific consideration. Location Hotel ERGIFE, Rome Italy Date Friday December 13 and Saturday ...

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      Mentions: Bruno Lumbroso
    23. Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests

      Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests

      Notal Vision, Inc., a company focused on advancing eye care with precision medicine by extending disease management from the clinic to the home, celebrates the completion of six million patient tests performed with ForeseeHome, the first FDA-cleared home-monitoring device for patients with intermediate dry Age-related Macular Degeneration (AMD) at risk for developing wet AMD. ForeseeHome uses a patented technology, Preferential Hyperacuity Perimetry® (PHP), that can identify minute changes in the central 14 degrees of visual field before the patient has any visual symptoms. During the test, which takes about three minutes, the central macula is evaluated for changes in metamorphopsia ...

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      Mentions: Notal Vision
    24. MGH Receives NIH Grant for Quantitative Biomechanics Imaging

      MGH Receives NIH Grant for Quantitative Biomechanics Imaging

      Massachusetts General Hospital Receives a 2019 NIH Grant for $340,916 for Quantitative Biomechanics Imaging. The principal investigator is Seok-Hyun Andy Yun. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. TRD 1 The proposed research in TRD Project 1 is to develop novel optical coherence tomography (OCT)-based techniques and tools for measuring the mechanical properties and parameters as well as acoustic transduction in tissues. The focus on tissue biomechanics responds to the emerging opportunity to harness OCT's unique capabilities to obtain quantitative maps of tissue vibration, deformation, strain, and ...

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