1. Optical Coherence Tomography News

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    1. Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign

      Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign

      The Biophotonics Imaging Laboratory at the Beckman Institute for Advanced Science and Technology on the campus of the University of Illinois Urbana-Champaign has immediate openings for a post-doctoral research associate and a graduate student in the area of otologic (ear) imaging using optical coherence tomography (OCT). Headed by Prof. Stephen Boppart, the Biophotonics Imaging Laboratory is a dynamic and productive interdisciplinary research and training environment focused on developing novel optical biomedical imaging technologies, translating them into clinical applications, and driving them toward commercialization for improving healthcare. 

      Successful candidates are expected to have a strong experimental research background in OCT hardware ...

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    2. Two Postdoc Openings at the Physical Optics and Biophotonics Group at Institute of Physical Chemistry, Warsaw, Poland

      Two Postdoc Openings at the Physical Optics and Biophotonics Group at Institute of Physical Chemistry, Warsaw, Poland

      This project aims to introduce and experimentally verify the authors' original description of physical processes related to the influence of light with partial spatial coherence on image reconstruction in the presence of optical heterogeneity. The proposed research works will allow for a better understanding of physical and technical limitations for imaging with partially spatially coherent light in systems with phase-sensitive (interferometric or holographic) detection. In this fundamental research program, we would like to solve one of the most basic problems of optics, which is in-vivo microscopic imaging in biological samples. This project aims to broaden our knowledge about the image ...

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    3. Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives NIH Grant for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging

      Ohio State University Receives a 2021 NIH Grant for $582,395 for Full Field OCT for Cellular Level Structural and Functional Retinal Imaging. The principal investigator is Nathan Doble. Below is a summary of the proposed work. The proposed design and construction of an optical coherence tomography (OCT) system, namely, a full-field (FF)-swept-source (SS)-OCT will allow rapid structural and functional measures of individual cone and rod photoreceptors (PRCs), the sub-retinal space (SRS) and retinal pigment epithelial (RPE) cells to an external light stimulus. Current OCT systems either have limited temporal resolution i.e. they are not fast enough ...

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    4. Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives NIH Grant for OCT Angiography for Neovascular Age-related Macular Degeneration

      Oregon Health and Science University Receives a 2021 NIH Grant for $471,602 for OCT Angiography for Neovascular Age-related Macular Degeneration. The principal investigator is Yali Jia. Below is a summary of the proposed work. Neovascular age-related macular degeneration (AMD), characterized by the presence of choroidal neovascularization (CNV), accounts for the majority of AMD related vision loss. Invasive dye-based fluorescein angiography (FA) remains the gold standard for CNV detection. Using high-speed OCT systems, we have developed novel OCT angiography (OCTA) technologies to image CNV as well as vascular plexuses associated with AMD. Our recent clinical studies have demonstrated that (1 ...

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    5. Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hospital Receives NIH Grant for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection

      Massachusetts General Hospital Receives a 2021 NIH Grant for $46,036 for Volumetric mapping of tissue microstructure with OCT for enhanced dysplasia detection. The principal investigator is Taylor Cannon. Below is a summary of the proposed work. Better imaging-based screening and surveillance methods stand to improve patient outcomes in cancers that are typically diagnosed at late stages, such as esophageal adenocarcinoma (EAC). Although success- ful proactive treatment options are available to patients diagnosed with low- or high-grade dysplasia, many at-risk patients are diagnosed at later stages with few effective treatment options, leading to high mortality rates. Dysplasia is diagnosed based ...

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    6. University of California at Los Angeles Receives NIH Grant for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery.

      University of California at Los Angeles Receives NIH Grant for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery.

      University of California at Los Angeles Receives a 2021 NIH Grant for $557,751 for Intraocular Robotic Interventional and Surgical System for Automated Cataract Surgery. The principal investigator is Jean-Pierre Hubschman. Below is a summary of the proposed work. The long-term goals of the present study are to improve surgical outcomes and reduce the risk of surgical complications of cataract surgery. It is our central hypothesis that intraoperative stabilization of the ocular structures, complete lens extraction, and accurate positioning of the intraocular lens implant through robotic manipulations and optical coherence tomography (OCT) feedback will significantly improve the safety of critical ...

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    7. New England College of Optometry Receives NIH Grant for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo

      New England College of Optometry Receives NIH Grant for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo

      New England College of Optometry Receives a 2021 NIH Grant for $196,651 for Development of a Scheimpflug imaging equipped OCT system to measure gradient refractive index of the lens in the human eye in vivo. The principal investigator is Ji Change He. Below is a summary of the proposed work. The crystalline lens of the human eye grows throughout life with continuous change in its size, shape and internal structure. The lifetime growth of the lens generates a special structure inside the lens: the gradient distribution. From the lens surface to the lens center, the gradient distribution is characterized ...

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    8. Massachusetts General Hospital Receives NIH Grant for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT

      Massachusetts General Hospital Receives NIH Grant for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT

      Massachusetts General Hosptial Receives a 2021 NIH Grant for $199,976 for Lithium Niobate on Insulator (LNOI) Photonic Circuit Lasers for High-Speed, Wide-field OCT. The principal investigator is Benjamin Vakoc. Below is a summary of the proposed work. Despite advances in OCT technology over the past two decades, retinal OCT systems are still limited by their speed. This has many consequences on how OCT is used. Perhaps most significantly, current speeds restrict the imaged field to a fraction of the total retinal area. This prevents diseases of the peripheral retina from being imaged in routine OCT scans. Two recent technologies ...

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    9. University of Southern California Receives NIH Grant for Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives NIH Grant for Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography

      University of Southern California Receives a 2021 NIH Grant for $193,633 for Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography. The principal investigator is Brian Applegate. Below is a summary of the proposed work. There is a growing interest in the development of functional imaging with Optical Coherence Tomography (OCT). Many of these approaches to functional imaging rely on the exquisite phase sensitivity of the OCT interferometer. These include well established techniques like Doppler OCT for measuring blood flow as well as emerging applications like OCT elastography for measuring mechanical properties, and Magnetomotive OCT and ...

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    10. Oregon Health & Science University Receives NIH Grant for Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma

      Oregon Health & Science University Receives NIH Grant for Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma

      Oregon Health & Science University Receives a 2021 NIH Grant for $500,718 for Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma. The principal investigator is Yali Jia. Below is a summary of the proposed work. Glaucoma damage to the optic nerve and impairment of vision are progressive and irreversible. Understanding mechanisms of glaucomatous injury will help to develop new approaches for treatments that can be used along with traditional therapies that lower intraocular pressure (IOP). Recent developments in optical coherence tomography (OCT) angiography have brought increased attention to the role of the inner retinal circulation ...

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    11. Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives NIH Grant for Multi-contrast dynamic optical imaging to advance live developmental biology

      Stevens Institute of Technology Receives a 2021 NIH Grant for $468,446 for Multi-contrast dynamic optical imaging to advance live developmental biology. The principal investigator is Shang Wang. Below is a summary of the proposed work. Imaging is essential for the study of developmental biology. In particular, optical imaging, with its high resolution, has been making revolutionary impacts on our understanding of biological development. To a large degree, the imaging capability defines what can be studied in developmental biology. From 2D to 3D, from static to dynamic, advancements in optical imaging have enabled us to connect molecular genetics with volumetric ...

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    12. New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives NIH Grant for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography

      New York University School of Medicine Receives a 2021 NIH Grant for $468,446 for True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence Tomography. The principal investigator is Vivek Srinivasan. Below is a summary of the proposed work. The earliest changes in the photoreceptors, retinal pigment epithelium, and Bruch’s membrane in age-related macular degeneration (AMD) are subtle and challenging to detect non-invasively. Here, we will develop and validate a new in vivo imaging technology, visible light Optical Coherence Tomography (OCT), which, if implemented carefully, delineates these layers with unprecedented depth resolution and functional contrast. The ability to precisely ...

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    13. Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives a 2021 NIH Grant for $468,446 for Enabling technology for image-guided robot-assisted sub-retinal injections. The principal investigator is Iulian Iordachita. Below is a summary of the proposed work. The goal of this proposal is to design, develop and evaluate a novel clinically compatible surgical platform for enhancing the retina surgeon's ability to provide therapy to the subretinal domain. Efficient, safe, reproducible delivery methods would enable safe and precise delivery of stem cell, nanoparticle and gene therapies for prevalent ocular diseases including but not limited to Age-related Macular Degeneration (AMD). The proposed cooperative surgical robot ...

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    14. Mechanical Engineer Endoscopy Job Opening at Glannaventa

      Mechanical Engineer Endoscopy Job Opening at Glannaventa

      Glannaventa is currently seeking an enthusiastic, creative medical device engineer to design, develop and implement critical components of the next-generation GEODE™ micro-endoscope and associated delivery system as part of our quest to develop an outpatient screening test for high-grade serous ovarian cancer. The majority of HGSOC, the most lethal histotype of ovarian cancer, is believed to originate in the epithelia of the distal Fallopian tubal structures, and then moves to the ovary and peritoneum, becoming aggressive and metastatic. Contemporary imaging and screening techniques do not have the resolution, sensitivity or specificity to permit early detection of the disease, so it ...

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    15. Wasatch Photonics announces the appointment of Neil Anderson as Vice President, Gratings and OCT

      Wasatch Photonics announces the appointment of Neil Anderson as Vice President, Gratings and OCT

      Wasatch Photonics is pleased to announce and welcome Neil Anderson, Ph.D. as the new Vice President of Gratings and OCT. In this role, Neil will be responsible for commercial leadership and growth of the company’s transmission gratings and optical coherence tomography business, working with the teams in Logan, UT, and Morrisville, NC, to develop innovative product solutions matched to current and emerging market needs in laser pulse compression, optical coherence tomography (OCT), astronomy, and photonics. Neil is a well-known and respected figure in the optics and photonics industry and brings 15 years of experience supporting customers with optical ...

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    16. Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital

      Employer Description Guillermo J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities ...

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    17. Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Employer Description Guillermo J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities ...

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    18. Ophthalmic Systems Architect at Zeiss

      Ophthalmic Systems Architect at Zeiss

      JOB SUMMARY: The Ophthalmic Systems Architect is responsible for driving systems architecture design, trade-off analysis, implementation, and validation across cloud-ready ophthalmic diagnostics products. This role collaborates with various functions within ZEISS to define systems requirements for performance, cost, manufacturability, serviceability, and reliability from hardware through software and user experience. The Ophthalmic Systems Architect works from concept phase through commercial launch to ensure meeting customer needs and exceeding their expectations. Deep passion and experience in developing consumer products from prototyping through productization is crucial for success in this role. ESSENTIAL FUNCTIONS: (Responsibilities that are central to the job and MUST be ...

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    19. Senior Scientist Opening at Carl Zeiss Meditec, Inc-Dublin, CA

      Senior Scientist  Opening at Carl Zeiss Meditec, Inc-Dublin, CA

      JOB SUMMARY: The Senior Scientist is responsible for the initiation, design, development, and implementation of scientific research projects to explore technology for future platform concepts and support the development and execution of product roadmaps. Will investigate the feasibility of applying scientific principles and concepts to potential inventions and products. Maintains substantial knowledge of state-of-the-art principles and theories and may contribute to scientific literature and conferences. May participate in development of intellectual property and visit clinical sites and interact with the market to provide inputs to the R&D teams about various possible system design improvements. May identify and work with ...

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    20. University of Arizona Receives NIH Grant for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting

      University of Arizona Receives NIH Grant for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting

      University of Arizona Receives a 2021 NIH Grant for $693,571 for Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting . The principal investigator is Rongguang Liang. Below is a summary of the proposed work. Oral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancer worldwide, accounting for 400,000 new cancer cases each year. Two-thirds of these cancers occur in low- and middle-income countries (LMICs). While the 5-year survival rate in the U.S. is 62%, the survival rate is only 10- 40% and cure rate around 30% in ...

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    21. University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement

      University of North Carolina Receives NIH Grant for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement

      University of North Carolina Receives a 2021 NIH Grant for $797,092 for Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement. The principal investigator is Amy Oldenburg. Below is a summary of the proposed work. Subglottic stenosis (SGS) is one of the most common life-threatening airway disorders in infants and children. Current treatment methods are based on airway endoscopy, which provides only qualitative information. Surgical treatment failures for the most severe grades of SGS range toward 50%, often due to post-operative airway collapse in new, unpredicted locations. Treatment ...

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    22. MGH Receives NIH Grant for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging

      MGH Receives NIH Grant for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging

      Massachusetts General Hospital Receives a 2021 NIH Grant for $210,000 for Developmental sensorimotor and cognitive pathways in infant cerebellum with multi-scale imaging. The principal investigator is Hui Wang. Below is a summary of the proposed work. Development of the human cerebellum undergoes a precisely programmed sequence of processes, spanning from the third trimester of pregnancy into the first postnatal year. Due to advances in neonatal imaging techniques, cerebellar injury has been increasingly detected in premature infants and full-terms with birth complications. Although perinatal cerebellar injury and malformation have been broadly associated with developmental delays in motor, language, cognition, and ...

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    23. University of Alabama Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama Receives NIH Grant  for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama at Birmingham Receives a 2021 NIH Grant for $258,726 for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease. The principal investigator is Yuqiang Bai. Below is a summary of the proposed work. In humans, the precorneal tear film (PCTF) is a thin layer (~3-5 µm) of a complex biological fluid coating the ocular surface, that serves to nourish and protect the ocular surface and provide a smooth refractive optical surface for vision. In dry eye disease, the PCTF becomes thinner, and destabilizes (evaporates ...

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    24. MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hospital Receives a 2021 NIH Grant for $198,000 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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