1. Optical Coherence Tomography News

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    1. Feature Of The Week 10.16.2017: Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Feature Of The Week 10.16.2017: Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Three-dimensional (3D) tumor spheroid models have gained increased recognition as important tools in cancer research and anti-cancer drug development. However, currently available imaging approaches employed in high-throughput screening drug discovery platforms e.g. bright field, phase contrast, and fluorescence microscopies, are unable to resolve 3D structures deep inside (>50 μm) tumor spheroids. In this study, we established a label-free, non-invasive optical coherence tomography (OCT) imaging platform to characterize 3D morphological and physiological information of multicellular tumor spheroids (MCTS) growing from ~250 μm up to ~600 μm in height over 21 days. In particular, tumor spheroids of two cell lines glioblastoma ...

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    2. NinePoint Medical is featuring the NvisionVLE® Imaging System with Real-time Targeting™ at ACG 2017; Eight Scientific Abstracts to be Presented

      NinePoint Medical is featuring the NvisionVLE® Imaging System with Real-time Targeting™ at ACG 2017; Eight Scientific Abstracts to be Presented

      Visit us at ACG 2017! Booth #825 NinePoint Medical is featuring the NvisionVLE ® Imaging System with Real-time Targeting™ at ACG 2017; Eight Scientific Abstracts to be Presented NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, today announced that new clinical data relating to its proprietary NvisionVLE ® Imaging System with Real-time Targeting™ will be presented at two upcoming major conferences. Seven clinical abstracts will be featured at the World Congress of Gastroenterology @ the ACG 2017 conference taking place October 13-18 in Orlando, FL, and one poster session will be presented ...

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    3. Postdoctoral Fellow Positions at Case Western Reserve University

      Postdoctoral Fellow Positions at Case Western Reserve University

      Location: Case Western Reserve University, Cleveland, OH, 44106-7080 Application Deadline: Open until filled, available immediately Job description: Post-doctoral research training positions available immediately to join a team of biomedical engineers, neurobiologists, and electrophysiologists to assess the mechanisms by which infrared light (infrared neuromodulation - IRN) can modulate axons and neurons in ganglia as a therapeutic alternative to systemic drug delivery, as well as creating novel tools for visualizing and manipulating neurons and axons using infrared light. Successful applicants will be expected to work in an interdisciplinary team, including coordination with research and clinical collaborators and providing leadership to junior researchers. Outstanding ...

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    4. Postdoctoral Research Fellowship in Biomedical Optics at CNRS/Strasbourg University

      Postdoctoral Research Fellowship in Biomedical Optics at CNRS/Strasbourg University

      Applicants are invited to apply for a postdoctoral researcher position in optical imaging systems for biomedical applications. The project involves the development of the novel catheter-based OCT imaging system to enhance the robotized interventional endoscope for diagnosing and treatment of diseases in the digestive system. The successful candidate will work with the research group supported by the ATIP-Avenir grant awarded by the French National Center for Scientific Research (CNRS) and the French National Institute of Health and Medical Research (INSERM). The group is focused on highly interdisciplinary projects that bridge photonics and robotics to improve performance of microscopic imaging modalities ...

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    5. Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos

      Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos

      Imaging of living cells based on traditional fluorescence and confocal laser scanning microscopy has delivered an enormous amount of information critical for understanding biological processes in single cells. However, the requirement for a high numerical aperture and fluorescent markers still limits researchers’ ability to visualize the cellular architecture without causing short- and long-term photodamage. Optical coherence microscopy (OCM) is a promising alternative that circumvents the technical limitations of fluorescence imaging techniques and provides unique access to fundamental aspects of early embryonic development, without the requirement for sample pre-processing or labeling. In the present paper, we utilized the internal motion of ...

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    6. University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives NIH Grant for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue

      University of California at Davis Receives a 2017 NIH Grant for $78,500 for A Fiber-Coupled Multimodal Imaging Platform for In Vitro Assessment of Engineering Tissue. The principal investigator is Benjamin Sherlock. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. Cardiovascular disease is a leading cause of death globally. In vitro engineering of replacement blood vessels has emerged as a promising area of research that has the potential to provide lifesaving therapy in patients where autologous bypass grafts are not possible. The challenges of vascular tissue engineering require the developing samples ...

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    7. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives a 2017 NIH Grant for $225,116 for Method for Accurate Retinal Oxygen Metabolic Rate Extraction. The principal investigator is Wenzhong Liu. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. DR is a secondary complication of diabetes and a leading cause of blindness in the world. Although it is well known that DR is driven by ischemia, the current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non-proliferative DR and angiogenesis in proliferative DR. As a result, when ...

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    8. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant  for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives a 2017 NIH Grant for $559,269 for Functional and Structural Optical Coherence Tomography for Glaucoma. The principal investigator is David Huang. The program began in 2013 and ends in 2021. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnosis and close monitoring of glaucoma are important because the onset is insidious and the damage is irreversible. Advanced imaging modalities such as optical coherence tomography (OCT) have been used in the past 2 decades to improve the objective evaluation of glaucoma. OCT has higher axial spatial resolution ...

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    9. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of treating these devastating diseases is a formidable task. Nevertheless, trials examining novel therapeutic strategies are underway. An important key to success in the early phases of such trials is selection ...

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    10. Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives NIH Grant for Low Cost Retinal Optical Coherence Tomography for Point of Care Use

      Lumedica Receives a 2017 NIH Grant for $25,000 for Low Cost Retinal Optical Coherence Tomography for Point of Care Use. The principal investigator is William Brown. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system for use in point of care settings. The target system price will be one third the price of currently available research OCT system while providing system performance comparable to other entry level OCT imaging systems. By breaking ...

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    11. Massachusetts General Hospital Receives NIH Grant The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2017 NIH Grant for $171,000 The Center for Biomedical OCT Research and Translation. The principal investogator is Brett Bouma. THe progbram began in 2017 and ends in 2018. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource will ...

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    12. Feature Of The Week 10/1/2017: Optical Coherence Tomography: from Healthcare Idea to Healthcare Impact.

      Feature Of The Week 10/1/2017: Optical Coherence Tomography: from Healthcare Idea to Healthcare Impact.

      The commercialization and growth of OCT which has occurred over the past 25 years has been highly impactful scientifically, clinically, and economically. Many factors have helped drive this success starting with the clinical need for new cost-effective high-resolution minimally-invasive imaging solutions for various diagnostic and therapeutic applications. But equally important to this success was the intertwined role of researchers, engineers, clinicians, professional societies, government agencies, government funding, regulatory bodies, entrepreneurs, venture capitalists, and small and large corporate entities within the biomedical optics industry and other industries. This talk will review some of the history of the commercialization of OCT and ...

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    13. Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT on December 15th in Rome Italy which Already has over 1,000 Attendees.

      Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT  on December 15th in Rome Italy which Already has over 1,000 Attendees.

      The fifth international congress on OCT Angiography, "en face" OCT, and advances in OCT will take place in Rome Italy on December 15th an 16th. The meeting has its own personality: it brings together both the clinical and basic science communities, has high scientific contents and good organization, friendly atmosphere, sweet weather and Rome beauty. The conference organizers include Bruno Lumbroso, David Huang, Gabriel Coscas, Yali Jia, K. Bailey Freund, Richard Rosen, Philip Rosenfeld, David Sarraf, Eric Souied, Richard Spaide, Giovanni Staurenghi, Nadia Waheed. Quan Dong Nguyen, SriniVas Sadda, Yves Cohen, Wolfgang Drexler, Joseph Carroll, and Ursula Schmidt Erfurth. The ...

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    14. Postdoctoral Researcher Opening for "Nanosensitive OCT - Biomechanics of the Eye" at the National University of Ireland, Galway

      Postdoctoral Researcher Opening for "Nanosensitive OCT - Biomechanics of the Eye" at the National University of Ireland, Galway

      Applications are invited from suitably qualified candidates for a full-time, fixed term position as a photonics technology postdoctoral research scientist with the Tissue Optics and Microcirculation Imaging Facility Laboratory (TOMI) at the National University of Ireland, Galway. This position is funded by a mix of commercial and public funding. The position is available from the 1st of January 2018 on a two-year fixed term contract. Job Description: The successful candidate will be based in the Tissue Optics and Microcirculation Imaging Facility – part of the research Cluster for Photonics and Imaging - and will work closely with collaboration partners in Susana Marcos ...

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    15. Postdoctoral Researcher Opening For "Nanosensitive OCT - Cells and Tissues" at the National University of Ireland, Galway

      Postdoctoral Researcher Opening For "Nanosensitive OCT - Cells and Tissues" at the National University of Ireland, Galway

      Applications are invited from suitably qualified candidates for a full-time, fixed term position as a photonics technology postdoctoral research scientist with the Tissue Optics and Microcirculation Imaging Facility Laboratory (TOMI) at the National University of Ireland, Galway. This position is funded by the European Union Horizon 2020. The position is available from the 1st of January 2018 on a contract of up to four years. Job Description: The successful candidate will be based in the Tissue Optics and Microcirculation Imaging Facility – part of the research Cluster for Photonics and Imaging - and will work closely with collaboration partners in EU STARSTEM ...

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    16. Postdoctoral Researcher Opening for "Optical Coherence Tomography-Miniature OCT" National University of Ireland, Galway

      Postdoctoral Researcher Opening for "Optical Coherence Tomography-Miniature OCT"  National University of Ireland, Galway

      Postdoctoral Researcher in Photonics technologies ‘Optical Coherence Tomography - Miniature OCT ’ Tissue Optics and Microcirculation Imaging Laboratory School of Physics National University of Ireland, Galway Ref. No. NUIG TOMI02-17 Applications are invited from suitably qualified candidates for a full-time, fixed term position as a photonics technology postdoctoral research scientist with the Tissue Optics and Microcirculation Imaging Facility Laboratory (TOMI) at the National University of Ireland, Galway. This position is funded by a mix of commercial and public funding. The position is available from the 1st of November 2017 on a two-year fixed term contract. Job Description: The successful candidate will be ...

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    17. A postdoctoral research fellowship/research associate position at OHSU

      A postdoctoral research fellowship/research associate position at OHSU

      A postdoctoral research fellowship/research associate position is immediately available in the Center for Ophthalmic Optics and Lasers, Casey Eye Institute, Oregon Health & Science University. The fellowship will focus on the development and clinical application of medical imaging system, especially OCT and related technologies (laser-tissue interaction). Ph.D in Optics, Biomedical Engineering, Electrical Engineering or a related field is required. Demonstrated excellence in one or more of the following area is required: optical system set-up, image acquisition, simulation using Zemax software and C++/GPU programming for real-time processing. Broad experience in optics, signal processing, and image processing are also desirable ...

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    18. Avinger Receives CE Marking Approval for In-Stent Restenosis Treatment Indication With Pantheris Image-Guided Atherectomy

      Avinger Receives CE Marking Approval for In-Stent Restenosis Treatment Indication With Pantheris Image-Guided Atherectomy

      Avinger, Inc. (NASDAQ: AVGR ), a leading developer of innovative treatments for Peripheral Artery Disease (PAD), today announced Conformité Européenne (CE) Marking approval for treating in-stent restenosis with the Pantheris® Lumivascular atherectomy system. In-stent restenosis occurs when a previously blocked artery treated with a stent becomes narrowed again, blocking blood flow. Physicians often face challenges when treating in-stent restenosis both in terms of safety and efficacy. From a safety standpoint, limitations in imaging techniques such as X-ray fluoroscopy and the inability to control the directionality of other treatment modalities’ mechanism of action creates the concern of potentially impacting the integrity ...

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    19. Iowa City VA Receives NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging

      Iowa City VA  Receives NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging

      Iowa City VA Medical Center Receives a 2017 NIH Grant for Automated Assessment of Optical Nerve Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury, and from idiopathic causes. Currently, the diagnosis of papilledema and its severity are assessed by direct funduscopic observation or digital fundus photographs using a six-stage grading scale. The scale ...

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    20. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes. The principal investigator is David Boas. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography (OCT ...

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    21. New study proves advantages of MultiColor imaging over fundus photography for early diagnosis and monitoring of AMD

      New study proves advantages of MultiColor imaging over fundus photography for early diagnosis and monitoring of AMD

      A research group from the Centre for Public Health at the Queen’s University in Belfast, Northern Ireland, has just published the results of a study comparing SPECTRALIS® MultiColor imaging and traditional color fundus photography for the detection of features of early and late age-related macular degeneration (AMD). The study’s findings demonstrate the benefits of SPECTRALIS MultiColor imaging for increased sensitivity and specificity. The study, which was published digitally in August and will appear in the November issue of Retina, is titled: “Identifying features of early and late AMD: A comparison of MultiColor versus traditional color fundus photography”. The ...

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    22. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives a 2017 NIH Grant for $37,696 Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey. The program began in 2017 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for activation ...

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    23. Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives NIH Grant for Imaging Structure and Function

      Stanford University Receives a 2017 NIH Grant for $139,730 for Imaging Structure and Function. The principal investigator is Thomas Clandinin. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Imaging technologies such as confocal microscopy, multiphoton microscopy and super- resolution imaging as well as optical coherence tomography have transformed the ability of scientists to observe structural and functional changes in the visual system, in vivo and ex vivo, in both health and disease. The overarching goal of the imaging core is to transform the ability of vision scientists to use these ...

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    24. Feature Of The Week 09/17/2017: Non-Destructive Analysis of the Internal Anatomical Structures of Mosquito Specimens Using Optical Coherence Tomography

      Feature Of The Week 09/17/2017: Non-Destructive Analysis of the Internal Anatomical Structures of Mosquito Specimens Using Optical Coherence Tomography

      The study of mosquitoes and analysis of their behavior are of crucial importance in the on-going efforts to control the alarming increase in mosquito-borne diseases. Furthermore, a non-destructive and real-time imaging technique to study the anatomical features of mosquito specimens can greatly aid the study of mosquitoes. In this study, we demonstrate the three-dimensional imaging capabilities of optical coherence tomography (OCT) for structural analysis of Anopheles sinensis mosquitoes. The anatomical features of An. sinensis head, thorax, and abdominal regions, along with the morphology of internal structures, such as foregut, midgut, and hindgut, were studied using OCT imaging. Two-dimensional and three-dimensional ...

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