1. Optical Coherence Tomography News

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    1. University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives a 2016 NIH Grant for $662,015 for Interferometric Optophysiology of the Human Retina. The principal investigator is Austin Roorda. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Our goal is to develop a new technology for non-invasive optical monitoring of activity of individual retinal neurons and their light-driven inputs at cellular resolution, in the living human retina. If successful, this technology will provide an entirely new and objective approach to understand and monitor treatment of retinal disease, thereby transforming scientific studies of the eye ...

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    2. OCT Medical Imaging Inc. Receives a NIH Grant for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System

      OCT Medical Imaging Inc. Receives a NIH Grant for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System

      OCT Medical Imaging Inc. Receives a 2016 NIH Grant for $1,252,899 for Clinical Evaluation and Development of a Diagnostic Multi-modal Intravascular Imaging System. The principal investigator is Tirunelveli Ramalingam. The program began in 2015 and ends in 2018. Below is a summary of the proposed work. Understanding that not a single imaging technique can alone address needs of all vascular diagnosis, OCT medical imaging Inc. (OCTMI) propose to develop a clinical multimodal intravascular imaging system encompassing ultra-high resolution optical coherence tomography (OCT) and IVUS. This Combined multimodal vascular imaging system will permit cross-sectional visualization of vascular artery with ...

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    3. Johns Hopkins University Receives a NIH Grant for OCT to Distinguish BT Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer

      Johns Hopkins University Receives a NIH Grant for OCT to Distinguish BT Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer

      Johns Hopkins University Receives a 2016 NIH Grant for $48,576 for OCT to Distinguish BT Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer. The principal investigator is Carmen Kut. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. In brain cancers such as gliomas, aggressive removal of the solid tumor through surgery is associated with improved overall survival. In fact, i has been shown that at least 78% of the tumor has to be removed to make a meaningful difference in the patient's survival. Current techniques for tumor removal are limited ...

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    4. Johns Hopkins University Receives a NIH Grant for Tissue Pharmacology Imaging and Modeling

      Johns Hopkins University Receives a NIH Grant for Tissue Pharmacology Imaging and Modeling

      Johns Hopkins University Receives a 2016 NIH Grant for $542,099 for Tissue Pharmacology Imaging and Modeling. The principal investigator is Namandjen Bumpus. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. A successful microbicide product has pharmacokinetics (PK) that effect prophylactic pharmacodynamics (PD). Product design should manipulate candidate compositions, volumes, and drug packaging in a rational manner to yield target PK/PD; but we have limited understanding of this relationship. Further, our methods for experimentally evaluating PK in animals and humans are limited: they do not delineate drug concentration distributions throughout ...

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    5. Feature Of The Week 07/12/2016: OCT_Edit: A Free OCT Image Editor

      Feature Of The Week 07/12/2016: OCT_Edit: A Free OCT Image Editor

      OCT_Edit is a Matlab program with a graphical interface used to edit optical coherence tomography images. It works with raw k-clocked sample files, rather than bitmap images directly. Because of this, it can do background subtraction and dispersion compensation to create new sample files with a minimum loss of information. Windowing functions, color maps, black and white level cropping can be tried out very quickly. Watching the video tutorial within the presentation is the easiest way to learn about the capabilities of OCT_Edit. The editor source code and example image files are available for free upon request. Please email us ...

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    6. Special Issue: 25 Years of Optical Coherence Tomography

      Special Issue: 25 Years of Optical Coherence Tomography

      Commemorating the 25th anniversary of the development of Optical Coherence Tomography (OCT), the journal Investigative Ophthalmology & Visual Science ( IOVS ) has released a special issue with over 70 papers from authors on five continents. The special issue covers a wide range of topics, including OCT technology and methods, cornea/anterior, retina, age-related macular degeneration, diabetic retinopathy and glaucoma. To learn more click this link http://iovs.arvojournals.org/ss/octissue.aspx

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    7. UCLA Receives a NIH Grant for Detection of Glaucoma Progression With Macular OCT Imaging

      UCLA Receives a NIH Grant for Detection of Glaucoma Progression With Macular OCT Imaging

      The University of California at Los Angeles Receives a 2016 NIH Grant for $229,139 for Detection of Glaucoma Progression With Macular OCT Imaging. The principal investigator is Kourous Nouri-Mahdavi. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. This application is a formal request for a career development award (K23) for an academic glaucoma specialist with a serious interest in the role of imaging in glaucoma using optical coherence tomography (OCT). This will allow the candidate to establish a clinical research program with the main goal of improving detection of glaucoma ...

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    8. Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for $573,805 for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy. The principal investigator is Guillermo Tearney. The program began in $2014 and ends in 2019. Below is a summary of the proposed work. Celiac disease (CD) is an autoimmune response to gluten proteins that affects 3M people in the US and 50M worldwide. These proteins incite an inflammatory reaction that eventually destroys the absorptive villi in the duodenum, resulting in gastrointestinal symptoms, malabsorption, malnutrition, and an increased incidence of other autoimmune diseases, diabetes, and cancer. A definitive diagnosis of CD is ...

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    9. Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives a 2016 NIH Grant for $483,717 for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects. The principal investigator is Michael Jenkins. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Congenital heart defects (CHDs) are one of the most common and devastating birth defects, afflicting 32,000 babies born in the United States each year, and over 1 million Americans alive today. Altered hemodynamics during development has been shown to be a contributing factor to CHDs, regardless of whether ...

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    10. Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives NIH Grant for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $590,459 for Algorithms for MR and OCT-Based Architectonic and Laminar Segmentation. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The human brain is made up of an array of functionally and structurally defined regions. Localizing these regions is critical for early diagnosis of an array of diseases such as Alzheimer's disease (AD), as well as for neuroscientific research aimed at understanding the brain's functional and structural properties and clinical intervention in drug-resistant depression ...

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    11. Baylor College of Medicine Receives NIH Grant for Small Animal Visual System Module

      Baylor College of Medicine Receives NIH Grant for Small Animal Visual System Module

      Baylor College of Medicine Receives a 2016 NIH Grant for $139,554 for Small Animal Visual System Module. The principal investigator is Ching-Kang Chen. The program began in 2016 and ends in 2017. Below is a summary of the proposed work. Recent advance in genome editing technology will lead to an explosion of small animal models of human diseases. These animal models, when characterized efficiently and correctly, will benefit investigations that elucidate disease mechanisms and lead to exciting discovery of therapeutic interventions. The small animal visual system analysis module (SAVSAM) of the Baylor College of Medicine (BCM) Vision Core Facilities ...

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    12. Massachusetts General Hospital Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for the Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives a 2016 NIH Grant for $1,460,266 for the Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the propose work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the ...

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    13. Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes

      Massachusetts General Hosptial Receives a 2016 NIH Grant for $616,222 for Microscopic Imaging of Tissue Oxygen Delivery Altered By Microvascular Changes. The principal investigator is David Boas. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. The technology to characterize microvascular network dynamics and assess its impact on tissue oxygen delivery is only now emerging. We have recently demonstrated the unprecedented ability to map oxygen in the microvasculature and cerebral tissue with two-photon microscopy (TPM) [Sakadzic2010] and are proposing to complement this with our novel statistical intensity variation optical coherence tomography ...

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    14. Share your OCT Thesis on OCT News

      Share your OCT Thesis on OCT News

      OCT News is seeking links to bachelors, masters, and PhD theses in the area of "Optical Coherence Tomography". Traditionally student theses contain a great wealth of information but are rarely accessible to the OCT community. If you or someone you know wrote an OCT thesis and would like to share it with the community please submit a link or PDF using the "Contact OCT News" tab in the main menu bar or the feedback link in the footer and we will include it here: Student Theses. Thesis will only be included if the link is free of charge to users.

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    15. PhD Student Position in Optical Coherence Tomography in Biomedical Research at the TU Dresden, Germany

      PhD Student Position in Optical Coherence Tomography in Biomedical Research at the TU Dresden, Germany

      Within the scope of the junior research group “Optical Technologies in Medicine”, new methods in optical imaging are transferred into medical and clinical application. The research is focused on optical coherence tomography and other optical methods for the diagnosis of different diseases. The PHD student will join a group of medical scientists, engineers, information and natural scientists. Requirements You hold, or to be about to receive before starting the contract, a MSc degree in physics, optical engineering, electrical engineering or related areas with high interest in optical imaging. (up to 4 years after MSC degree) You have good programming skills ...

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    16. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of ...

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    17. Research Associate Position in OCT at the University of Maryland

      Research Associate Position in OCT at the University of Maryland

      Position description: A Postdoctoral Research Associate position is available at the University of Maryland, College Park. Research projects include intraoperative imaging of transplant kidney viability using OCT in collaboration with Georgetown University Medical Center, and development of automatic image processing algorithm to predict organ viability. Required expertise: Ph.D. in physics, electrical engineering, optical engineering, or biomedical/bioengineering. Hand-on experience on optical and electronic instrumentation and strong programming skills (Matlab, Labview, and C++). Prior research expertise on OCT and image processing. Application: Interested candidates should submit Curriculum vitae with a list of contact information of 3 references by email to ...

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    18. Postdoctoral Fellow Position at the Advanced Ophthalmic Imaging Laboratory at Indian Universitiy

      Postdoctoral Fellow Position at the Advanced Ophthalmic Imaging Laboratory at Indian Universitiy

      The Advanced Ophthalmic Imaging Laboratory at Indiana University is looking to fill a postdoctoral fellow or research associateposition. The successful candidate will join a team of scientists and engineers that are developing the next-generation adaptive optics–optical coherence tomography (AO-OCT) system for studying structure and function of the living human retina at the cellular level. The system will open up exciting new directions to study both normal and pathological vision. The laboratory ( www.opt.indiana.edu/dtmiller/Index.aspx ) is part of the Indiana University Visual Optics Group, an active and well-funded community of vision scientists and engineers working in ...

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    19. Coin-Sized Scanner to Target Blindness

      Coin-Sized Scanner to Target Blindness

      A European group of scientists are working on the development of a breakthrough, compact, cost-effective retinal scanner that will play a key role in targeting the early diagnosis of retinal diseases that are worldwide leading causes of blindness. Funded by the Photonics PPP platform, OCTChip is set to revolutionise diagnosis of retinal diseases and prevent millions of cases of blindness. Diabetic Retinopathy accounts for the leading cause of blindness, with 200 million cases worldwide, and 60 million affected Europeans. With an ageing population, higher life expectancies and rising levels of diabetes, the number of cases preventable blindness are increasing. The ...

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    20. Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives NIH Grant for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function

      Massachusetts General Hospital Receives a 2016 NIH Grant for $742,986 for Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function. The principal investigator is David Sosnovik. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. Pressure overload of the left and right ventricles initially leads to adaptive hypertrophy. This, however, is frequently followed by maladaptive hypertrophy, heart failure and death. We hypothesize here that changes in 3D myocardial fiber architecture play a significant role in the deleterious transition from adaptive to maladaptive hypertrophy and heart failure. We further hypothesize that ...

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    21. State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received NIH Grant for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents

      State University of New York Stony Brook Received a 2016 NIH Grant for $195,071 for Optical Platform to Image Neuronal And Visual Effects of Cocaine In Awake Rodents. The principal investigator is Congwu Du. The program began in 2016 and ends in 2018. Below is a summary of the propose work. The medial prefrontal cortex (mPFC) plays a critical role in cocaine addiction. The mechanism underlying mPFC dysfunction in cocaine abusers are not well understood and could reflect disruption of cerebral blood flow (cocaine’s vascular effects) and/or disruption of dopaminergic modulation of the prefrontal cortex (cocaine’s ...

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    22. Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives a 2016 NIH Grant for $416,250 for Quantitative Optical Imaging of Cilia-Driven Fluid Flow. The principal investigator is Michael Choma. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Respiratory diseases are major causes of pediatric morbidity and mortality. These diseases are incompletely understood, which is a barrier to improving clinical care. Therefore, new mechanisms of disease need to be discovered. Optical imaging (e.g. optical coherence tomography [OCT]) will enable these discoveries since traditional imaging (e.g. x-ray, CT, MRI) cannot visualize structures smaller than ~1 mm ...

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    23. Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives a 2016 NIH Grant for $746,856 for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo. The principal investigator is Robert Brown. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. This Biomedical Research Partnership (BRP) proposal involves a partnership among a biomedical engineering team, a pulmonary physiology team, and a clinical pulmonary medicine team. This research program will incorporate state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human obstructive lung diseases (OLD). Optical coherence tomography (OCT) is ...

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    24. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives  NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      University of Illionois at Urbana-Champaign Receives a 2016 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investiagator is Stephen Boppart. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...

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