1. Optical Coherence Tomography News

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    1. Post-doctoral Research Fellowship at FDA – Microglial imaging

      Post-doctoral Research Fellowship at FDA – Microglial imaging

      A postdoctoral research fellowship is available at the Food and Drug Administration (FDA), Center for Devices and Radiological Health (CDRH), Office of Science and Engineering Laboratories (OSEL), Division of Biomedical Physics (DBP). The fellow will participate in an FDA inter-center collaborative research project in the lab of Dr. Ethan Cohen to optically evaluate the sensitivity of microglia at detecting toxins in retinal tissue using fluorescent and reflectance techniques. The fellow should be familiar with handling live retinal tissue, optical system design, and immunocytochemistry. The qualified candidate should have a Ph.D. in Neuroscience, Engineering, Physiology, Pharmacology, or a Vision-related field ...

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      Mentions: FDA Ethan D. Cohen
    2. University of Illinois at Chicago Receives NIH Grant for Functional Imaging of Retinal Photoreceptors

      University of Illinois at Chicago Receives NIH Grant  for Functional Imaging of Retinal Photoreceptors

      The University of Illinois at Chicago Received at 2017 NIH Grant for $299,044 for Functional Imaging of Retinal Photoreceptoers. The principal investigator is Zincheng Yao. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. Many eye diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR) and glaucoma, involve pathological changes in retinal photoreceptors and/or inner retinal neurons. It is well known that different diseases can target different cell types. In principle, physiological modification must occur in diseased cells, before detectable abnormality of retinal morphology. Therefore, functional evaluation of retinal ...

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    3. UC Irvine Receives at NIH for Combined OCT/US/PAT System for Intravascular Imaging

      UC Irvine Receives at  NIH for Combined OCT/US/PAT System for Intravascular Imaging

      University of California at Irvine Received at 2017 NIH Grant for $686,184 for Combined OCT/US/PAT System for Intravascular Imaging. The principal investigator is Zhongping Chen. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, cholesterol, fibrous constituents, monocytes, and various other inflammatory cells in the arterial wall. Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. The major cause of deaths from heart attacks (86%) and brain aneurysm (45%) are due ...

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    4. Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada

      Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada

      Location : Ottawa, ON and Boucherville, QC Optical coherence tomography (OCT) is an imaging technique that captures volumetric images of a scattering medium. Because of its interferometric nature, it is robust to local variations of light intensities and only requires a direct line of sight. Triangulation-based 3D imaging (laser scanning or structured-light systems), on the other hand, can perform fast surface measurements on large working volumes but requires two lines of sight. A hybrid technology would allow fast acquisition speed, large coverage, and capability of inspecting hard-to-reach surfaces. We thus seek a postdoctoral fellow (PDF) to lead the development of this ...

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    5. Postdoc Opening in Image Processing and/or GUI Development at University of California, Los Angeles

      Postdoc Opening in Image Processing and/or GUI Development  at University of California, Los Angeles

      RESEARCH FIELDS: Ophthalmic image segmentation, registration, and/or web-based GUI development RESEARCH LABORATORY: Doheny Image Analysis Laboratory (DIAL) at Doheny Eye Institute, University of California, Los Angeles ACTIVITY: DIAL is a rapidly growing and interdisciplinary group to investigate new approaches for image segmentation, registration, visualization, and analysis in various multimodal ophthalmic images at Doheny Eye Institute, standing among the top recipients of medical research grants from the National Institutes of Health, which fund 80% of all vision research in America. We are particularly interested in the development of various novel image segmentation, registration algorithms, and/or web-based GUI development, and ...

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    6. Mechanical Design Engineer Opening at Optovue

      Mechanical Design Engineer Opening at Optovue

      Scope: TheMechanical Engineer role provides an opportunity to work with a highly cross-functional group of scientists and engineers to contribute towards next generation products in the field of ophthalmic imaging. The candidate will lead mechanical and opto-mechanical aspects of the sub-systems design in new product development as well as sustaining engineering projects. Strong verbal and written communications skills are essential, and you must be able to multitask and work effectively at all levels in a fluid environment. Interested candidates please contact: sarika_gulhar@optovue.com and/or renata_bartula@optovue.com. Responsibilities: Design of machines, mechanism, machined, sheet-metal, die casting and injection ...

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    7. Columbia University Receives NIH Grant for Ultrasound Perfusion Imaging in Glaucoma

      Columbia University Receives NIH Grant for Ultrasound Perfusion Imaging in Glaucoma

      Columbia University Receives a 2017 NIH Grant for $411,119 for Ultrasound Perfusion Imaging in Glaucoma. The principal investigator is Ronald Silverman. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Glaucoma is an optic neuropathy and the leading cause of blindness, affecting over 3 million people in the United States. Elevated intraocular pressure (IOP) is a well-known risk factor for this disease, but reduced ocular perfusion is also now appreciated to be an important risk factor in primary open-angle glaucoma (POAG), the most common form of glaucoma. While optical methods such ...

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    8. USC Receives NIH Grant for 3D OCT Angiography for Quantitative Characterization of Diabetic Retinopathy

      USC Receives NIH Grant for 3D OCT Angiography for Quantitative Characterization of Diabetic Retinopathy

      University of Southern California Receives a 2017 NIH Grant for $206,250 for 3D OCT Angiography for Quantitative Characterization of Diabetic Retinopathy. The principal investigator is Youngang Shi. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. In the clinical diagnosis of diabetic retinopathy (DR), fluorescein angiography (FA) is currently the only method used routinely for the detection and treatment of ischemia, but it is an invasive method and not sensitive to early microvascular changes before the onset of visual symptoms. For the early detection and management of ischemia in DR, Optical ...

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    9. University of Washington Received NIH Grant Optical Coherence Elastography of Corneal Dynamics

      University of Washington Received NIH Grant Optical Coherence Elastography of Corneal Dynamics

      The University of Washington Received a 2017 NIH Grant for $529,475 Optical Coherence Elastography of Corneal Dynamics. The principal investigator is Tueng Shen. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not ...

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    10. Pennsylvania State University Receives NIH Grant for Score2 Comparative Trial (SCT)

      Pennsylvania State University Receives NIH Grant for Score2 Comparative Trial (SCT)

      Pennsylvania State University Received a 2017 NIH Grant for $769,262 for Score2 Comparative Trial (SCT). The principal investigator is Ingrid Scott. The program began in 2013 and ends in 2019. Below is a summary of the proposed work. This comparative effectiveness research proposal aims to support a multicenter, prospective, randomized, NIH-defined phase III clinical trial to compare treatment protocols for decreased vision due to macular edema secondary to central retinal vein occlusion (CRVO) based on results of recent randomized trials. This application is an investigator-initiated project in response to Program Anouncement Number PAR-10-207. The trial is designed to assess ...

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    11. OHSU Receives NIH Grant for Dynamic Changes in the Chick Developing Heart in Response to Altered Hemodynamics

      OHSU Receives NIH Grant for Dynamic Changes in the Chick Developing Heart in Response to Altered Hemodynamics

      Oregon Health & Science University Receives a 2017 NIH Grant for $414,360 for Dynamic Changes in the Chick Developing Heart in Response to Altered Hemodynamics. The principal investigator is Sandra Rugonyi. The program began in 2008 and ends in 2018. Below is a summary of the proposed work. Project Summary About 1% newborn babies have congenital heart disease (CHD), the leading cause of death among children. The majority of CHD cases are believed not to have a genetic cause. Other factors, such as abnormal blood flow during embryonic and fetal stages can lead to heart malformations and thus CHD through ...

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    12. Stanford Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      Stanford Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      Stanford University Receives a 2017 NIH Grant for $364,249 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay between passive mechanical structures and active OHC- based processes. While laser Doppler vibrometry has added tremendously to our understanding of cochlear physiology, this technique is limited. Only motion from one ...

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    13. OHSU Receives NIH Grant for Studies in Glaucomatous Optic Nerve Damage

      OHSU Receives NIH Grant  for Studies in Glaucomatous Optic Nerve Damage

      Oregon Health & Science University Receives a 2017 NIH Grant for $562,073 for Studies in Glaucomatous Optic Nerve Damage. The principal investigator is John Morrison. The program began in 1993 and ends in 2018. Below is a summary of the proposed work. Understanding cellular mechanisms of axonal injury from elevated intraocular pressure (IOP) is essential for developing glaucoma treatments that will protect the optic nerve. We have determined that an 8- hour exposure to Controlled Elevation of IOP (CEI) in anesthetized rats will reproduce optic nerve injury and gene expression changes within the optic nerve head (ONH) that are characteristic ...

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    14. Florida International University Receives NIH Grant for Imaging The Functional Biomarkers of Photoreceptors

      Florida International University Receives  NIH Grant  for Imaging The Functional Biomarkers of Photoreceptors

      Florida International University Receives a 2017 NIH Grant for $495,185 for Imaging The Functional Biomarkers of Photoreceptors. The principal investigator is Shuliang Jiao. The program began in 2017 and ends in 2021. Below is summary of the proposed work. “Vision is the most fundamental of our senses and it is perhaps the greatest tragedy of all when blindness robs us of this modality”. Photoreceptors are light-detecting cells initiating vision. Loss of photoreceptor leads to loss of vision. This happens in millions of Americans with hereditary retinal degenerations or age-related macular degeneration (AMD). Loss of vision is not only a ...

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    15. Stanford Receives NIH Grant f for Influence of Hair Bundle Properties on Cochlear Mechanics

      Stanford Receives NIH Grant f for Influence of Hair Bundle Properties on Cochlear Mechanics

      Stanford University Receives a 2017 NIH Grant for $56,694 for Influence of Hair Bundle Properties on Cochlear Mechanics. The principal investigator is James Dewey. The program began in 20-17 and ends in 2020. Below is a summary of the proposed work. Normal hearing depends on the delicate mechanotransduction apparatus of inner ear hair cells – the stereociliary hair bundle. Cochlear vibrations deflect the hair bundle, which converts mechanical stimulation to electrical signals via gating of mechanosensitive ion channels. Hair bundle transduction is critical for hearing, as it is required for afferent signaling by inner hair cells, and for activation of ...

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    16. UCDavis Receives NIH Grant for Improving Penetration Depth and Spatial Resolution for In Vivo Deep Imaging of Mouse Brain Using 2200nm Optical Coherence Microscopy

      UCDavis Receives NIH Grant for Improving Penetration Depth and Spatial Resolution for In Vivo Deep Imaging of Mouse Brain Using 2200nm Optical Coherence Microscopy

      University of California at Davis Receives a 2017 NIH Grant for $78,500 for Improving Penetration Depth and Spatial Resolution for In Vivo Deep Imaging of Mouse Brain Using 2200nm Optical Coherence Microscopy. The principal investigator is Shau Chong. The program began in 20-17 and ends in 2-019. Below is a summary of the proposed work. Subcortical pathology is a common feature in aging, Alzheimer's disease and vascular dementia but has been challenging to study with micron resolution in vivo. Optical methods such as two-photon microscopy image the superficial cortex at the micron-scale, but the resolution of these conventional ...

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    17. Georgetown University Receives NIH Grant for Non-Invasive Evaluation f Transplant Kidney using OCT

      Georgetown University Receives NIH Grant  for Non-Invasive Evaluation f Transplant Kidney using OCT

      Georgetown University Receives a 2017 NIH Grant for $349,058 for Non-Invasive Evaluation f Transplant Kidney using OCT. The principal investigator is Peter Andrews. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. There is currently a worldwide shortage of kidneys for transplantation due mainly to the fact that there is no reliable means to determine their viability (i.e., kidneys stored for long periods of time, etc.). Also, following transplantation, kidneys oftn do not function immediately and their status is unclear. Previously, we have shown that the histopathology of living, superficial ...

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    18. Opportunity Research Assistant/Associate in Biophotonics and Endoscopic Imaging at Imperial College London

      Opportunity Research Assistant/Associate in Biophotonics and Endoscopic Imaging at Imperial College London

      Job Title: Research Assistant/Associate in Biophotonics and Endoscopic Imaging Department/Division/Faculty: The Hamlyn Centre for Robotic Surgery in association with Department of Computing, Faculty of Engineering Department of Surgery and Cancer, Faculty of Medicine Advert: Research Assistant salary: £31,740 to £33,370 per annum Research Associate salary: £36,070 to £43,350 per annum S outh Kensington Campus Fixed term appointment until 31 st May 2019 Applicants are invited to apply for a new vacancy at either Research Assistant (pre-doctoral) or Research Associate (post-doctoral) level for biophotonics and endoscopic imaging. The Hamlyn Centre is dedicated to developing ...

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    19. MIT Receives a 2017 NIH Grant for Novel Diagnostics with Optical Coherence Tomography

      MIT Receives a 2017 NIH Grant for Novel Diagnostics with Optical Coherence Tomography

      MIT Receives a 2017 NIH Grant for $395,107 for Novel Diagnostics with Optical Coherence Tomography. The principal investigatyor is James Fujimoto. THe program began in 1985 adn ends in 2020/ Below is a summary of hte proposed workd This proposal is a resubmission of a competing renewal application for an ongoing collaborative program among investigators at the Massachusetts Institute of Technology, New England Eye Center and University of Pittsburgh Medical Center Eye Center. This is a multidisciplinary program which integrates imaging technology research, clinical and small animal imaging studies. The specific aims are: Aim 1. Next generation OCT technology ...

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    20. Feature of The Week 03/26.2017: Segmentation of nucleus and cytoplasm of a single cell in 3D tomogram using OCT

      Feature of The Week 03/26.2017: Segmentation of nucleus and cytoplasm of a single cell in 3D tomogram using OCT

      uclear-to-cytoplasmic (N/C) ratio is an effective feature to distinguish cancer cells from their normal counterparts. In conventional cytopathology, cells printed or smeared on a glass slide were stained and then evaluated by two-dimensional (2D) images through light microscopy. A random rayburst sampling (RRBS) framework was developed to detect the nucleus and cell membrane boundaries in three-dimensional (3D) space. Raw images were acquired through a full-field optical coherence tomography (FF-OCT) system with submicron resolution—i.e. 0.8 µm in lateral and 0.9 µm in axial direction. The near isometric resolution enables 3D segmentation of nucleus and cell membrane ...

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    21. Columbia University Receives NIH Grant for Studying Models and Mechanisms of Optic Nerve Diseases

      Columbia University Receives NIH Grant  for Studying Models and Mechanisms of Optic Nerve Diseases

      Columbia University Receives at 2017 NIH Grant for $460,107 for Studying Models and Mechanisms of Optic Nerve Diseases. The principal investigato ris Donald Hood. The program began in 1977 and ends in 2019. Below is a summary of the proposed work. Glaucoma is the second leading cause of blindness in the world, but, with proper treatment, blindness can be avoided in the overwhelming majority of individuals. Our long-term goal is to improve the detection of early glaucomatous damage, as well as the detection of progression of such damage. We focus in large part on damage to the macula, the ...

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    22. MedLumics Secures 34.4 Million Euros in Series B Funding for OCT Guided Treatment of Atrial Fibrillation

      MedLumics Secures 34.4 Million Euros in Series B Funding for OCT Guided Treatment of Atrial Fibrillation

      MedLumics, a cardiac device company specializing in optically guided minimally invasive instruments, announced today that it has raised 34.4 million Euros in financing that will be used to help advance the product and clinical development of the company’s AblaView catheter, intended for the treatment of atrial fibrillation (AF) and other arrhythmias. This financing is the largest in the history of medtech in Spain and one of the largest in Europe this year. Led by Edmond de Rothschild Investment Partners (EdRIP), the Series B round included funding from new investors Seroba Life Sciences, Innogest Capital and a strategic investor ...

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    23. Share your OCT Thesis on OCT News

      Share your OCT Thesis on OCT News

      OCT News is seeking links to bachelors, masters, and PhD theses in the area of "Optical Coherence Tomography". Traditionally student theses contain a great wealth of information but are rarely accessible to the OCT community. If you or someone you know wrote an OCT thesis and would like to share it with the community please submit a link or PDF using the "Contact OCT News" tab in the main menu bar or the feedback link in the footer and we will include it here: Student Theses. Thesis will only be included if the link is free of charge to users.

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    24. Feature Of The Week 03/12/2017: Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT

      Feature Of The Week 03/12/2017: Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT

      Breast cancer is one of the leading cause of mortality in women. Optical coherence tomography (OCT) enables three dimensional visualization of biological tissue with micrometer level resolution at high speed, and can play an important role in early diagnosis and treatment guidance of breast cancer. In this study, we imaged human breast tissue using two spectral domain OCT systems at different wavelengths: a home-built ultra-high resolution (UHR) OCT system at 840nm (measured as 2.72 µm axial and 5.52 µm lateral) and a commercial OCT system at 1300nm with standard resolution (measured as 6.5 µm axial and 15 ...

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