1. Optical Coherence Tomography News

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    1. Feature Of The Week 06/27/2017: Depth-of-Focus Extension in Optical Coherence Tomography via Multiple Aperture Synthesis

      Feature Of The Week 06/27/2017: Depth-of-Focus Extension in Optical Coherence Tomography via Multiple Aperture Synthesis

      In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture radar (SAR). Using numerical simulations and imaging experiments, we verified that this technique can maintain a diffraction-limited transverse resolution along a DOF that is ∼10 times larger than the confocal ...

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    2. University of California at Berkeley Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives a 2017 NIH Grant for $618,742 for Interferometric Optophysiology of the Human Retina. The principal investigato is Austin Roorda. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Our goal is to develop a new technology for non-invasive optical monitoring of activity of individual retinal neurons and their light-driven inputs at cellular resolution, in the living human retina. If successful, this technology will provide an entirely new and objective approach to understand and monitor treatment of retinal disease, thereby transforming scientific studies of the eye ...

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    3. Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives NIH Grant for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo

      Johns Hopkins University Receives a 2017 NIH Grant for $750,287 for Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease In Vivo. The principal investigator is Robert Brown. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. This Biomedical Research Partnership (BRP) proposal involves a partnership among a biomedical engineering team, a pulmonary physiology team, and a clinical pulmonary medicine team. This research program will incorporate state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human obstructive lung diseases (OLD). Optical coherence tomography (OCT) is ...

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    4. Compact Imaging Teams with SRI International for Dynamic Biometrics Development under IARPA Odin Program

      Compact Imaging Teams with SRI International for  Dynamic Biometrics Development under IARPA Odin Program

      Compact Imaging, Inc. (CI) today announced that SRI International has selected CI’s non-invasive depth scanning sensor, MRO™, as a critical component in the development of “dynamic biometrics” for improved detection of attempts to evade or deceive biometric security systems, such as fingerprint scanners. The development is being performed under a multi-year contract awarded to SRI as part of IARPA’s (Intelligence Advanced Research Projects Activity, National Intelligence Directorate) Odin Program. The goal of the Odin Program is to develop advanced technologies to detect “presentation attacks,” as attempts to deceive biometric security systems are often called. Conventional biometrics, such as ...

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    5. Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives NIH Grant for Quantitative Optical Imaging of Cilia-Driven Fluid Flow

      Yale University Receives a 2017 NIH Grant for $416,250 for Quantitative Optical Imaging of Cilia-Driven Fluid Flow. The principal investigator is Mustafa Khokha. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Respiratory diseases are major causes of pediatric morbidity and mortality. These diseases are incompletely understood, which is a barrier to improving clinical care. Therefore, new mechanisms of disease need to be discovered. Optical imaging (e.g. optical coherence tomography [OCT]) will enable these discoveries since traditional imaging (e.g. x-ray, CT, MRI) cannot visualize structures smaller than ~1 mm ...

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    6. Columbia University Receives NIH Grant for Structural and Functional Progression of Glaucomatous Damage or the Macula

      Columbia University Receives NIH Grant for Structural and Functional Progression of Glaucomatous Damage or the Macula

      Columbia University Receives a 2017 NIH Grant for $400,000 for Structural and Functional Progression of Glaucomatous Damage or the Macula. The principal investigator is Carlos De Moraes. The program began in 2015 and ends in 2018. Below is a summary of the proposed work. There is compelling evidence that glaucomatous damage to the macula occurs even in early stages of the disease. The macula comprises about 30% of all retinal ganglion cells and its information corresponds to over 50% of the visual cortex. However, glaucomatous damage to the macula is often missed in clinical practice. Some of the reasons ...

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    7. Johns Hopkins Receives a NIH Grant for Eye Determinants of Cognition (EYEDOC) Study

      Johns Hopkins Receives a  NIH Grant for Eye Determinants of Cognition (EYEDOC) Study

      Johns Hopkins Receives a 2017 NIH Grant for $711,223 for Eye Determinants of Cognition (EYEDOC) Study. The principal investigator is Alison Abraham. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Eye Determinants of Cognition (EyeDOC) Study Rationale: Dementia and mild cognitive impairment (MCI) pose enormous health and societal costs in our aging US population. While cerebral neural loss is known to contribute to Alzheimer's dementia, vascular diseases may contribute substantially to the total burden of dementia and its precursor, MCI. Small-vessel cerebrovascular changes, which are most strongly associated with ...

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    8. Beth Israel Deaconess Medical Center Receives NIH Grant for In Vivo Optical Detection of Dysplasia in Esophagus

      Beth Israel Deaconess Medical Center Receives  NIH Grant for In Vivo Optical Detection of Dysplasia in Esophagus

      Beth Israel Deaconess Medical Center Receives a 2017 NIH Grant for $598,587 for In Vivo Optical Detection of Dysplasia in Esophagus. The principal investigator is Lev Perelman. The program began in 2005 and ends in 2020. Below is a summary of the proposed work. Esophageal adenocarcinoma is the most common esophageal malignancy in Western world and the malignancy that is rising the fastest in the United States – approximately 7% per year over the past 30 years. It has very poor prognosis with less than 15% of patients alive 5 years after diagnosis. Worldwide, 482,300 new esophageal cancer cases ...

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    9. Zeiss Acquisition of Insight Ophthalmic Laser Engines for 19.1M Euros

      Zeiss Acquisition of Insight Ophthalmic Laser Engines for 19.1M Euros

      On 24 February 2017 a contract was concluded between Carl Zeiss Meditec, Inc., Dublin USA, and Insight Photonics Solutions, Inc. (hereinafter “Insight”), which domiciled in Lafayette, USA, pertaining to the acquisition of 52 percent of the shares in Ophthalmic Laser Engines, LLC, Lafayette, USA (hereinafter referred to as “OLE”). The main aim of acquiring these shares is to develop and produce an akinetic swept source laser for ophthalmology, and the associated OCT system elements. Departing from the voting rights distribution, a profit distribution of 30% for Insight was agreed until 31 December 2022, which allocated as a performance-related component to ...

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    10. Research Associate in Biomedical Optics and Inverse Problems at University College of London

      Research Associate in Biomedical Optics and Inverse Problems at University College of London

      University College London - Department of Medical Physics & Biomedical Engineering Biomedical Optics Research Laboratory (BORL) UCL’s Department of Medical Physics and Biomedical Engineering conducts internationally leading research across a broad range of biomedical imaging techniques. Funding has recently been awarded to undertake an exciting pilot project known as computed microscopy. This project is a collaboration between the department’s Biomedical Optics Research Laboratory (BORL) and Centre for Medical Image Computing (CMIC) and could have a significant impact upon the fields of optical microscopy and optical coherence tomography. The core aim of the project is to solve the inverse problem of ...

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    11. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography

      Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography

      Northwestern University Receives a 2017 NIH Grant for $48,576 for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography. The Principal Investigator is Brian Soetikno. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The retina is one of the most metabolically active tissues in the human body, making it particularly susceptible to hypoxia. In diabetic retinopathy (DR), aberrant oxygen metabolism has been hypothesized to play a pivotal role its pathogenesis. An improved understanding of how imbalances in oxygen delivery and demand lead to the progression of DR ...

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    12. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      Glaucoma is characterized by an irreversible damage of retinal ganglion cells within the optic nerve head (ONH) at the back of the eye. Currently we know that elevated intraocular pressure (IOP) is associated with increased prevalence of glaucoma but not all glaucoma patients have an elevated IOP. The biomechanical theory of glaucoma hypothesizes that elevated (or fluctuating) IOP deforms the ONH tissues, including the lamina cribrosa (LC), and that these deformations drive retinal ganglion cell injury and death. However, IOP is not the only load that can deform the ONH. Eye movements have recently been hypothesized to be able to ...

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    13. Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography

      Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography

      Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Using shear wave elastography, the shear modulus of a soft tissue can be quantified by tracking the shear wave propagation. In previous measurements, the transverse shear wave propagates perpendicular to the force direction, so the shear modulus in the lateral region of the force can be quantified. However, the shear modulus in the axial region of the force cannot be measured. Dr. Jiang ...

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    14. Faculty Position at Geisinger Medical Center

      Faculty Position  at Geisinger Medical Center

      JOB SUMMARY: The Department of Imaging Science and Innovation within the Biomedical and Translational Informatics Institute at Geisinger Medical Center in Danville, PA is seeking to hire faculty members at all levels (Assistant, Associate and Professor). The ideal candidate will have a background in engineering, computer science, mathematics, radiology, or related field. In particular, emphasis will be placed on applicants with a record of research accomplishments in translational imaging and image processing, machine learning, and the intersection between radiology and genomics. A successful candidate will have high potential to establish a strong individual research program within a highly collaborative environment ...

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    15. Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography

      Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography

      The airway epithelium is coated with a biopolymeric mucus gel which is responsible for trapping inhaled environmental contaminants that are subsequently removed by mucociliary clearance (MCC). MCC is disrupted under high mucus wt%, causing mucus stagnation, chronic infection and inflammation. Normal mucus hydration by the epithelium is impaired in cystic fibrosis (CF) and COPD resulting in high mucus wt% that leads to halted MCC. Hypertonic saline (HS) treatment is a therapeutic approach to reduce mucus wt% for sustained MCC that has gained popularity due to its relative safety, easy administration, and low cost. However, patient to patient variability, conflicting therapeutic ...

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    16. Post-Doctoral Fellowship at York University (Canada) – Optical Coherence Tomography

      Post-Doctoral Fellowship at York University (Canada) – Optical Coherence Tomography

      A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) and clinical device R&D is available in the Hybrid Biomedical Optics Lab (York University, Canada). The fellowship focuses on development of novel photothermal imaging technologies based on OCT and radiometry for diagnostic imaging of soft and hard tissues. The fellowship can be extended up to 3 years . Job Requirements : A PhD (or equivalent) in Electrical Engineering, Physics or a related field is required. Demonstrated excellence in one or more of the following areas is required: optical coherence tomography, optical imaging systems, optical design, optical system fabrication, fiber ...

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    17. PhD Student Position in the Field of Photo-Thermal Optical Coherence Tomography at York University (Canada)

      PhD Student Position in the Field of Photo-Thermal Optical Coherence Tomography at York University (Canada)

      PhD student positions are immediately available in the Hybrid Biomedical Optics Lab (York University, Canada) in the field of optical coherence tomography. HBO Lab’s vision is to overcome the diagnostic shortcomings of the conventional reflectance optical imaging methods by development and advancement of hybrid optical imaging platforms (www.HBOLab.ca). The laboratory is looking for highly motivated students with background in theoretical and experimental optics. Experience in one or more of the following areas is desired: OCT and optical imaging systems, optical design, lasers, fiber optics, digital signal processing, LabView or C++ programming, and circuit design. Positions are fully ...

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    18. PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a PhD position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in October 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government by ...

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    19. USC ReceivesNIH Grant for Defining the Relationship of Retinal MIcrocirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African Americans

      USC ReceivesNIH Grant for Defining the Relationship of Retinal MIcrocirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African Americans

      University of Southern California Receives a 2017 NIH Grant for $223,560 for Defining the Relationship of Retinal MIcrocirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African Americans. The principal investigator is Grace Richter. The program began in 2017 and ends in 2022. Below is a summary of the proposed work. This K23 application is submitted by Grace Richter, MD, MPH, an Assistant Professor of Ophthalmology in the Glaucoma Division at the USC Roski Eye Institute at Keck School of Medicine of University of Southern California. The primary objectives of this K23 career development proposal are: 1) to ...

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    20. University of Miami Receives NIH Grant for Reversible Dysfunction of Retinal Ganglion Cells in Glaucoma

      University of Miami Receives NIH Grant for Reversible Dysfunction of Retinal Ganglion Cells in Glaucoma

      The University of Miami Receives a 2017 NIH Grant for $310,837 for Reversible Dysfunction of Retinal Ganglion Cells in Glaucoma. The principal investigator is Vittorio Porciatti. The program began in 2003 and ends in 2018. Below is a summary of the proposed work. Glaucoma causes progressive damage and death of retinal ganglion cells (RGCs) resulting in blindness. The prevalence of the disease will rise to a projected 3 million Americans by 2020. Our long-term goal is to prevent RGC death in the early stages of glaucoma and preserve vision. The objective of this study is to identify dysfunctional RGCs ...

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    21. Stanford University Receives NIH Grant for Cochlear Mechanics in the Mouse

      Stanford University Receives NIH Grant for Cochlear Mechanics in the Mouse

      Stanford University Receives a 2017 NIH Grant for $307,982 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex biomechanics of ...

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    22. Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients

      Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients

      Massachusetts General Hospital Receives a 2017 NIH Grant for $865,789 for Intracoronary Imaging of Plaque Collagen in Patients. The principal investigator is Seemantini Nadkarni. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The goal of this proposal is to develop and validate an intracoronary imaging device for the assessment of plaque collagen content and architecture in patients. Acute myocardial infarction (AMI), caused by the rupture of unstable plaque, is the leading cause of death worldwide. Collagen and vascular smooth muscle cells (vSMCs) together impart mechanical stability to a plaque, and ...

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    23. Physical Sciences ReceivesNIH Grant for Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 Diabetes

      Physical Sciences ReceivesNIH Grant  for Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 Diabetes

      Physical Sciences Incorporated Receives a 2017 NIH Grant for $230,823 for Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 Diabetes. The principal investigator is Mircea Mujat. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. There is currently a significant need for new non-invasive imaging techniques able to accurately quantify biomarkers for early detection, diagnosis, and quantification of complications in type 1 diabetes (T1D) such as diabetic retinopathy (DR). Physical Sciences Inc. (PSI) proposes to develop an imaging platform based on a new detection arrangement retrofitted to ...

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