1. Articles from Jennifer E. Phipps

    1-7 of 7
    1. Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber

      Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber

      We present a novel fiber-based imaging platform that allows simultaneous fluorescence lifetime imaging (FLIm) and optical coherence tomography (OCT) using a double-clad fiber. This platform acquires co-registered images showing structural and compositional contrast in unlabeled biological samples by scanning the fiber tip across the sample surface. In this Letter, we report a characterization of each modality and show examples of co-registered FLIm and OCT images acquired from a lemon segment and a section of human coronary artery. The close comparison between the combined FLIm and OCT images and a co-registered histology section provides a qualitative validation of the technique and ...

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    2. Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images Effects of Light Scattering

      Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images Effects of Light Scattering

      Background— Intravascular optical coherence tomography (IVOCT) images are recorded by detecting light backscattered within coronary arteries. We hypothesize that non–thin-capped fibroatheroma (TCFA) causes may scatter light to create the false appearance of IVOCT TCFA. Methods and Results— Ten human cadaver hearts were imaged with IVOCT (n=14 coronary arteries). IVOCT and histological TCFA images were coregistered and compared. Of 21 IVOCT TCFAs (fibrous cap <65 μm, lipid arc >1 quadrant), only 8 were true histological TCFA. Foam cell infiltration was responsible for 70% of false IVOCT TCFA and caused both thick-capped fibroatheromas to appear as TCFA, and the appearance ...

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    3. Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study

      Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study

      To investigate the clinical significance of bright spots in coronary plaque detected by optical coherence tomography (OCT) in patients with coronary artery disease. We identified 112 patients [acute coronary syndromes (ACS): n = 50, stable angina pectoris (SAP): n = 62] who underwent OCT imaging of the culprit lesion. A novel OCT algorithm was applied to detect bright spots representing the juxtaposition of a variety of plaque components including macrophages. The density of bright spots within the most superficial 250 μm of the vessel wall was measured at the site of culprit lesion. Bright spot density in the culprit lesion was significantly ...

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    4. Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool

      Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool

      Intravascular optical coherence tomography (IVOCT) continues to be a hot topic as a method for studying vulnerable plaque in research laboratories across the globe. It is also growing in popularity as a tool for interventional cardiologists to guide percutaneous coronary intervention (PCI). The power of IVOCT for diagnosis of thin-capped fibroatheromas (TCFAs) has yet to receive mainstream clinical attention due to the fact that clinicians still do not have a protocol to follow if TCFA are identified and that TCFA identification requires extensive training in IVOCT image analysis—it is not yet an automated process. In this review, we will ...

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    5. Can Multimodal Invasive Imaging Be Used to Predict Periprocedural Myocardial Infarctions?

      Can Multimodal Invasive Imaging Be Used to Predict Periprocedural Myocardial Infarctions?

      More than 1 million percutaneous coronary interventions (PCIs) are performed per year in the United States. Although technological advances have significantly improved outcomes following PCI, 5% to 44% of PCI patients still experience periprocedural myocardial infarction (PMI). PMI can be either macro-sized (coronary dissection or occlusion of a side branch) or microvascular such as distal embolization and/or microvascular plugging. PMIs have recently been defined as Type 4a: cardiac troponin (cTn) levels >5× elevation above the 99th percentile upper reference limit (URL), but only if the baseline cTn levels were normal (≤99th percentile URL) 1 . In addition to the elevated ...

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    6. Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis

      Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis

      Aims The aim of this study was to validate novel imaging technology for simultaneous morphological and biochemical endogenous optical imaging of coronary atherosclerotic plaque. Methods and results Optical coherence tomography (OCT) generates high-resolution 3D images of plaque morphology and endogenous fluorescence lifetime imaging microscopy (FLIM) characterizes biochemical composition. Both imaging modalities rely on plaque's intrinsic optical characteristics, making contrast agents unnecessary. A multimodal OCT/FLIM system was utilized to generate luminal biochemical maps superimposed on high-resolution (7 µm axial and 13 µm lateral) structural volumetric images. Forty-seven fresh postmortem human coronary segments were imaged: pathological intimal thickening (PIT, n ...

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    7. Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Objectives We hypothesized that bright spots in intravascular optical coherence tomography (IVOCT) images may originate by co-localization of plaque materials of differing indices of refraction (IR). To quantitatively identify bright spots, we developed an algorithm that accounts for factors including tissue depth, distance from light source, and signal-to-noise ratio. We used this algorithm to perform a bright spot analysis of IVOCT images, and compared these results with histologic examination of matching tissue sections. Background Although bright spots are thought to represent macrophages in IVOCT images, studies of alternative etiologies have not been reported. Methods Fresh human coronary arteries (n=14 ...

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    1-7 of 7
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    1. (6 articles) University of Texas at Austin
    2. (6 articles) Marc D. Feldman
    3. (4 articles) Thomas E. Milner
    4. (2 articles) Harvard University
    5. (2 articles) University of Texas Health Science Center
    6. (2 articles) Massachusetts General Hospital
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    Macrophages and intravascular optical coherence tomography bright spots: a quantitative study Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis Can Multimodal Invasive Imaging Be Used to Predict Periprocedural Myocardial Infarctions? Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images Effects of Light Scattering Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study Short-term healing response after implantation of the thin-strut, fast-releasing sirolimus-eluting biodegradable polymer-coated Alex Plus stent: optical coherence tomography study