1. Articles from Anett Jannasch

    1-4 of 4
    1. 4D optical coherence tomography for imaging aortic valve dynamics ex vivo

      4D optical coherence tomography for imaging aortic valve dynamics ex vivo

      The mechanical components of the heart, especially the valves, are enormously stressed during lifetime and undergo different pathophysiological tissue transformations, which affect cardiac output and in consequence living comfort of affected patients. Calcific aortic valve stenosis (AVS) is the most common valve disease in modern industrial countries but the pathogenesis and progression of this disease is still unknown. Therefore, animal models, especially mouse models, are a powerfull tool to investigate this disease in more detail with high resolution imaging techniques like optical coherence tomography and video microscopy. A custom-made pump was used for artificial stimulation of aortic valves ex vivo ...

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    2. Imaging of aortic valve dynamics in 4D OCT New insights into murine aortic valve diseases

      Imaging of aortic valve dynamics in 4D OCT  New insights into murine aortic valve diseases

      The mechanical components of the heart, especially the valves and leaflets, are enormous stressed during lifetime. Therefore, those structures undergo different pathophysiological tissue transformations which affect cardiac output and in consequence living comfort of affected patients. These changes may lead to calcific aortic valve stenosis (AVS), the major heart valve disease in humans. The knowledge about changes of the dynamic behaviour during the course of this disease and the possibility of early stage diagnosis is of particular interest and could lead to the development of new treatment strategies and drug based options of prevention or therapy. 4D optical coherence tomography ...

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    3. 4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

      4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

      The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain during lifetime. Like all highly stressed materials, also these biological components undergo fatigue and signs of wear, which impinge upon cardiac output and in the end on health and living comfort of affected patients. Thereby pathophysiological changes of the aortic valve leading to calcific aortic valve stenosis (AVS) as most frequent heart valve disease in humans are of particular interest. The knowledge about changes of the dynamic behavior during the course of this disease and the possibility of early stage diagnosis could lead to ...

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    4. Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography

      Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography

      The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new treatment strategies. Animal models are suited for the development and evaluation of new experimental approaches and therefor innovative imaging techniques are necessary. In this study, we present the time resolved visualization of healthy and calcified aortic valves in an ex vivo artificially stimulated heart model with 4D optical coherence tomography and high-speed video microscopy.

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    1-4 of 4
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    1. (4 articles) Dresden University of Technology
    2. (4 articles) Edmund Koch
    3. (2 articles) Harbin Medical University
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