1. Articles from Steven Padilla

    1-2 of 2
    1. Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

      Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

      Glaucoma is a leading cause of blindness worldwide and results from damage to the optic nerve. Currently, intraocular pressure is the only treatable risk factor. Changes in aqueous outflow regulate pressure; regulation becomes abnormal in glaucoma. From inside the eye aqueous flows out through the trabecular meshwork into a venous sinus called Schlemm's canal, next into collector channels and finally returns to the episcleral vessels of the venous system. The location of aqueous outflow regulation is unknown. Ex vivo and in vivo studies implicate both pressure-dependent trabecular tissue motion and tissues distal to Schlemm's canal in regulation of ...

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    2. Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      The aqueous outflow system (AOS) is responsible for maintaining normal intraocular pressure (IOP) in the eye. Structures of the AOS have an active role in regulating IOP in healthy eyes and these structures become abnormal in the eyes with glaucoma. We describe a newly developed system platform to obtain high-resolution images of the AOS structures. By incorporating spectral domain optical coherence tomography (SD-OCT), the platform allows us to systematically control, image, and quantitate the responses of AOS tissue to pressure with a millisecond resolution of pulsed flow. We use SD-OCT to image radial limbal segments from the surface of the ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Washington
    2. (2 articles) Ruikang K. Wang
    3. (2 articles) Massachusetts General Hospital
    4. (1 articles) Sepideh Hariri
    5. (1 articles) Roberto Reif
    6. (1 articles) Harvard University
    7. (1 articles) The Chinese University of Hong Kong
    8. (1 articles) University of Miami
    9. (1 articles) VU University Amsterdam
    10. (1 articles) David A. Boas
    11. (1 articles) Brett E. Bouma
    12. (1 articles) Johannes F. de Boer
    13. (1 articles) Frank D. Verbraak
    14. (1 articles) Apollo Medical Optics
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