1. Articles from Michael Kalloniatis

    1-10 of 10
    1. Assessment of angle closure spectrum disease as a continuum of change using gonioscopy and anterior segment optical coherence tomography

      Assessment of angle closure spectrum disease as a continuum of change using gonioscopy and anterior segment optical coherence tomography

      Purpose Studies examining the anterior chamber angle and angle closure disease often compare quantitative angle information obtained using anterior segment optical coherence tomography (ASOCT) with one of several ordinal scales derived using gonioscopy. We test the assumption that the ordinal gonioscopic angle grades have equal step sizes and can be analysed using metric statistics. Methods The medical records of 214 consecutive patients who were referred for assessment of the anterior chamber angle were prospectively examined using gonioscopy and ASOCT (Spectralis Optical Coherence Tomography, OCT, www.heidelbergengineering.com ). Anterior chamber angle parameters (angle opening distance, AOD, and trabecular‐iris space area ...

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    2. Multimodal imaging characteristics of congenital grouped hyper‐ and hypo‐pigmented fundus lesions

      Multimodal imaging characteristics of congenital grouped hyper‐ and hypo‐pigmented fundus lesions

      Background The imaging characteristics of congenital grouped pigmentation of the retinal pigment epithelium (CGP‐RPE) and its non‐pigmented variant – grouped congenital albinotic retinal pigment epithelial spots (GCARPES) are poorly defined in the literature. Our case series reports their multimodal imaging characteristics across a spectrum of presentations. Methods A retrospective review of patient records was conducted on patients seen at the Centre for Eye Health between January and December 2016. The multimodal imaging findings across four cases is described using optical coherence tomography (OCT), infrared imaging, ultra‐widefield imaging, fundus photography and fundus autofluorescence (FAF). Results Case 1 is a ...

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    3. Remote Grading of the Anterior Chamber Angle Using Goniophotographs and Optical Coherence Tomography: Implications for Telemedicine or Virtual Clinics

      Remote Grading of the Anterior Chamber Angle Using Goniophotographs and Optical Coherence Tomography: Implications for Telemedicine or Virtual Clinics

      Purpose : To evaluate the agreement and accuracy of grading goniophotographs and anterior segment optical coherence tomography (AS-OCT) results for assessment of the anterior chamber angle, and elicit factors driving concordance between perceived grade and ground truth. Methods : Three clinicians evaluated the goniophotographs and AS-OCT results of 75 patients. Graders' impressions of the angle grade, trabecular pigmentation, and iris contour were compared with the ground truth gonioscopic examination result when physically performed by a senior optometrist. Percentage agreement and kappa statistics were calculated. Binary logistic regression was used to elicit factors for accurate grading. Results : Exact angle matches and binary (open ...

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    4. Vascular Changes in Intermediate Age-Related Macular Degeneration Quantified Using Optical Coherence Tomography Angiography

      Vascular Changes in Intermediate Age-Related Macular Degeneration Quantified Using Optical Coherence Tomography Angiography

      Purpose : To examine changes in retinal vasculature and ganglion cell layer (GCL) thickness in intermediate age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Methods : Zeiss Cirrus Angioplex OCTA 6 × 6 mm scans and a macula 512 × 128 cube scans of the central retina were taken of 63 eyes with intermediate AMD and 51 control eyes. For OCTA scans, the superficial and deep capillary plexus were automatically segmented and vascular density quantified as total number of pixels contributing to the blood flow signal detectable by OCTA. Images were then skeletonized and vessel length, diameter index, morphology, and branching complexity ...

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    5. Development of a spatial model of age-related change in the macular ganglion cell layer to predict function from structural changes

      Development of a spatial model of age-related change in the macular ganglion cell layer to predict function from structural changes

      Purpose To develop location specific models of normal, age-related changes in the macular ganglion cell layer (GCL) from optical coherence tomography (OCT). Using these OCT-derived models, we predicted visual field (VF) sensitivity and compared these results to actual VF sensitivities. Design Retrospective cohort study Methods Single eyes of 254 normal participants were retrospectively enrolled from the Centre for Eye Health (Sydney, Australia). Macular GCL measurements were obtained using Spectralis OCT. Cluster algorithms were performed to identify spatial patterns demonstrating similar age-related change. Quadratic and linear regression models were subsequently utilized to characterize age-related GCL decline. 40 participants underwent additional testing ...

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    6. An evidence-based approach to the routine use of optical coherence tomography

      An evidence-based approach to the routine use of optical coherence tomography

      Optical coherence tomography is an imaging technology that has revolutionised the detection, assessment and management of ocular disease. It is now a mainstream technology in clinical practice and is performed by non-specialised personnel in some settings. This article provides a clinical perspective on the implications of that movement and describes best practice using multimodal imaging and an evidence-based approach. Practical, illustrative guides on the interpretation of optical coherence tomography are provided for three major diseases of the ocular fundus, in which optical coherence tomography is often crucial to management: age-related macular degeneration, diabetic retinopathy and glaucoma. Topics discussed include: cross-sectional ...

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    7. An evidence‐based approach to the routine use of optical coherence tomography

      An evidence‐based approach to the routine use of optical coherence tomography

      Optical coherence tomography is an imaging technology that has revolutionised the detection, assessment and management of ocular disease. It is now a mainstream technology in clinical practice and is performed by non‐specialised personnel in some settings. This article provides a clinical perspective on the implications of that movement and describes best practice using multimodal imaging and an evidence‐based approach. Practical, illustrative guides on the interpretation of optical coherence tomography are provided for three major diseases of the ocular fundus, in which optical coherence tomography is often crucial to management: age‐related macular degeneration, diabetic retinopathy and glaucoma. Topics ...

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    8. OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

      OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

      Purpose: White dot syndromes (WDS) are a group of inflammatory conditions characterized by white lesions at the retina and choroid level. Detection and monitoring of these syndromes are currently hampered by the subtlety of these lesions, making them difficult to image using traditional clinical techniques. New imaging modalities such as optical coherence tomography (OCT) and fundus autofluorescence (FAF) offer new opportunities for clinicians to noninvasively image WDS. Methods: A literature search was performed using a variety of WDS as the search terms. All articles from January 2004 to May 2014 were analyzed for clinical information regarding imaging of the diseases ...

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    9. Cirrus HD-OCT Short-Term Repeatability of Clinical Retinal Nerve Fiber Layer Measurements

      Cirrus HD-OCT Short-Term Repeatability of Clinical Retinal Nerve Fiber Layer Measurements

      Purpose: The detection of changes in the retinal nerve fiber layer (RNFL) as measured by optical coherence tomography (OCT) is crucial in glaucoma diagnosis and management. We investigated the short-term repeatability of peripapillary RNFL measurements in a commercially available spectral domain OCT focusing on a broad clinical spectrum of patients. Methods: Two consecutive peripapillary RNFL measurements were taken on 227 eyes with Cirrus HD-OCT (Carl Zeiss Meditec, Version 6.5 software) using the optic disc 200 x 200 protocol. Repeatability was assessed as Bland-Altman limits of agreement and intraclass coefficients (ICCs). Results: Limits of agreement showed the greatest variability in ...

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    10. The usefulness of multimodal imaging for differentiating pseudopapilloedema and true swelling of the optic nerve head: a review and case series

      The usefulness of multimodal imaging for differentiating pseudopapilloedema and true swelling of the optic nerve head: a review and case series

      Ophthalmic practitioners have to make a critical differential diagnosis in cases of an elevated optic nerve head. They have to discriminate between pseudopapilloedema (benign elevation of the optic nerve head) and true swelling of the optic nerve head. This decision has significant implications for appropriate patient management. Assessment of the optic disc prior to the advanced imaging techniques that are available today (particularly spectral domain optical coherence tomography and fundus autofluorescence), has mainly used diagnostic tools, such as funduscopy and retinal photography. As these traditional methods rely on the subjective assessment by the clinician, evaluation of the elevated optic nerve ...

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    1-10 of 10
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  2. Topics in the News

    1. (6 articles) University of New South Wales
    2. (2 articles) Carl Zeiss Meditec
    3. (1 articles) Heidelberg Engineering
    4. (1 articles) Optos
    5. (1 articles) Academic Medical Center at the University of Amsterdam
    6. (1 articles) Jichi Medical University
    7. (1 articles) University of Milan
    8. (1 articles) Bern University Hospital
    9. (1 articles) Capital Medical University
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    The usefulness of multimodal imaging for differentiating pseudopapilloedema and true swelling of the optic nerve head: a review and case series Cirrus HD-OCT Short-Term Repeatability of Clinical Retinal Nerve Fiber Layer Measurements OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes An evidence‐based approach to the routine use of optical coherence tomography An evidence-based approach to the routine use of optical coherence tomography Development of a spatial model of age-related change in the macular ganglion cell layer to predict function from structural changes Vascular Changes in Intermediate Age-Related Macular Degeneration Quantified Using Optical Coherence Tomography Angiography Remote Grading of the Anterior Chamber Angle Using Goniophotographs and Optical Coherence Tomography: Implications for Telemedicine or Virtual Clinics Multimodal imaging characteristics of congenital grouped hyper‐ and hypo‐pigmented fundus lesions Assessment of angle closure spectrum disease as a continuum of change using gonioscopy and anterior segment optical coherence tomography Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections