1. Articles from Darius M. Moshfeghi

    1-3 of 3
    1. Speckle-modulating optical coherence tomography in living mice and humans

      Speckle-modulating optical coherence tomography in living mice and humans

      Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo . As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution. Using SM-OCT, we reveal small structures in the tissues of living animals, such as ...

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    2. High-resolution contrast-enhanced optical coherence tomography in mice retinae

      High-resolution contrast-enhanced optical coherence tomography in mice retinae

      Optical coherence tomography (OCT) is a noninvasive interferometric imaging modality providing anatomical information at depths of millimeters and a resolution of micrometers. Conventional OCT images limit our knowledge to anatomical structures alone, without any contrast enhancement. Therefore, here we have, for the first time, optimized an OCT-based contrast-enhanced imaging system for imaging single cells and blood vessels in vivo inside the living mouse retina at subnanomolar sensitivity. We used bioconjugated gold nanorods (GNRs) as exogenous OCT contrast agents. Specifically, we used anti-mouse CD45 coated GNRs to label mouse leukocytes and mPEG-coated GNRs to determine sensitivity of GNR detection in vivo ...

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    3. Spectral-Domain Optical Coherence Tomography of Emulsified Subretinal Silicone Oil Presenting as a Macular Inverted Pseudohypopyon

      Spectral-Domain Optical Coherence Tomography of Emulsified Subretinal Silicone Oil Presenting as a Macular Inverted Pseudohypopyon

      The authors present a rare case of an inverted pseudohypopyon due to subretinal emulsified silicone oil in the macula of a patient who underwent pars plana vitrectomy surgery for repair of retinal detachment with proliferative vitreoretinopathy 1 year prior to presentation of this finding. The patient’s predisposing diagnosis is pathologic myopia.

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Stanford University
    2. (2 articles) Adam de la Zerda
    3. (2 articles) Debasish Sen
    4. (2 articles) Elliott D. SoRelle
    5. (2 articles) Orly Liba
    6. (1 articles) Optovue
    7. (1 articles) Thorlabs
    8. (1 articles) Bausch & Lomb
    9. (1 articles) Gunma University
    10. (1 articles) Movu
    11. (1 articles) Tomey Corporation
    12. (1 articles) Carl Zeiss Meditec
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