1. Articles from Takao Hirano

    1-9 of 9
    1. Deposits on retinal surface seen on optical coherence tomography in ocular amyloidosis

      Deposits on retinal surface seen on optical coherence tomography in ocular amyloidosis

      Objective: To investigate the tomographic features in patients with hereditary amyloidosis transthyretin (hATTR). Design: Retrospective case series and analysis of B-scan optical coherence tomography (OCT) images. Participants: A total of 120 patients (240 eyes) diagnosed with hATTR. Methods: We performed a retrospective review of the treatment history and retrospective analysis of the OCT images of patients with hATTR. The parameters analyzed were the age at which the last OCT was performed, presence of ocular amyloidosis, history of pars plana vitrectomy (PPV), systemic treatment, and genetic mutations. Two independent evaluators evaluated the OCT images for characteristic needle-shaped pattern deposits on the ...

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    2. Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography

      Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography

      Purpose To evaluate retinal vessel quantity within various retinal structural layers using optical coherence tomography angiography (OCTA). Methods In this IRB-approved study, 22 normal eyes (from 22 subjects) were imaged using the Spectralis OCT2, with a 15 × 15 degree OCTA scan centered on fovea and two additional 15 × 5 degree OCTA scans, displaced temporally and nasally by 15 degrees along the fovea-Bruch’s membrane opening (BMO) axis. Following projection artifact removal (PAR), vessel quantity (i.e., amount of flow signal) within each retinal nuclear and plexiform layer was assessed across the scan and was plotted as a vessel quantity profile ...

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    3. Vitreoretinal interface slab in optical coherence tomography-angiography for detecting diabetic retinal neovascularization

      Vitreoretinal interface slab in optical coherence tomography-angiography for detecting diabetic retinal neovascularization

      Purpose To compare neovascularization (NV) identified in proliferative diabetic retinopathy (PDR) eyes by wide-field swept-source optical coherence tomography angiography (SS-OCTA) using vitreoretinal interface (VRI) slab images, composed by automated and manual segmentation, with that identified by fluorescein angiography (FA). Design Retrospective study. Subjects Forty-two eyes of 30 treatment-naïve PDR patients who visited the outpatient clinic of the Ophthalmology Department of Shinshu University from June 2018 through October 2019. Methods All patients underwent comprehensive ophthalmological examinations, including SS-OCTA and FA. Main Outcome Measures. NV detected by en face SS-OCTA 15 × 15-mm VRI slab images and FA in the same 15 ...

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    4. Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis

      Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis

      Optical coherence tomography angiography (OCTA) allows the retinal microvasculature to be visualized at various retinal depths. Previous studies introduced OCTA axial profile analysis and showed regional variations in the number and location of axially distinct vascular retinal plexuses. OCTA acquisition and processing approaches, however, vary in terms of their resulting transverse and axial resolutions, and especially the latter could potentially influence the profile analysis results. Our study imaged normal eyes using the Spectralis OCT2 with a full-spectrum, probabilistic OCTA algorithm, that, in marked contrast to split-spectrum approaches, preserves the original high OCT axial resolution also within the resulting OCTA signal ...

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    5. Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

      Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

      Aims To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes. Methods Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed. The area under the receiver operating characteristic curve was estimated to assess the ability of each image size ...

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    6. Extended field imaging using swept-source optical coherence tomography angiography in retinal vein occlusion

      Extended field imaging using swept-source optical coherence tomography angiography in retinal vein occlusion

      Purpose To evaluate the degree of ischemia in eyes with retinal vein occlusion (RVO) using swept-source optical coherence tomography angiography (SS-OCTA) with the extended field imaging (EFI) technique, which extends the area encompassed by SS-OCTA by scanning through trial frames fitted with a +20-diopter lens. Study Design Retrospective observational study. Methods Twenty-three consecutive eyes of 22 patients with RVO underwent 12 × 12 mm SS-OCTA imaging both with and without EFI for determination of extension rate. Two graders blinded to the clinical data evaluated the degree of retinal ischemia in paired EFI-SS-OCTA and fluorescein angiography (FA) images, and the concordance rates ...

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    7. Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy

      Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy

      Aims To examine the feasibility of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) with extended field imaging (EFI) for evaluation of the retinal vasculature in diabetic retinopathy (DR). Methods This study included 37 eyes of 27 patients (age, 65±10 years; male patients, 18; female patients, 9) with DR. All patients underwent comprehensive ophthalmological examination, including OCTA and fluorescein angiography (FA). The imaging methods were compared for visible field of view, presence and extent of non-perfused areas (NPAs), presence and number of new blood vessels (NVs), vessel density (VD) and patient comfort level measured by Visual Analogue Scale ...

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    8. Delineation of capillary dropout in the deep retinal capillary plexus using optical coherence tomography angiography in a patient with Purtscher’s retinopathy exhibiting normal fluorescein angiography findings: a case report

      Delineation of capillary dropout in the deep retinal capillary plexus using optical coherence tomography angiography in a patient with Purtscher’s retinopathy exhibiting normal fluorescein angiography findings: a case report

      Background Fat embolism in the deep retinal capillary plexus is one of the reported mechanisms underlying central/paracentral scotoma in patients with Purtscher’s retinopathy. Here we report the clear delineation of capillary dropout in the deep capillary plexus using optical coherence tomography angiography (OCTA) in a chronic case of unexplained scotoma that developed after femoral fracture. The patient exhibited normal fluorescein angiography (FA) findings and a normal retinal appearance. Case presentation A 42-year-old Japanese man with a history of bilateral, unexplained paracentral scotoma that developed after femoral fracture and pulmonary fat embolism due to a car accident 20 years ...

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    9. En face swept-source optical coherence tomography detecting thinning of inner retinal layers as an indicator of capillary nonperfusion

      En face swept-source optical coherence tomography detecting thinning of inner retinal layers as an indicator of capillary nonperfusion

      To report en face swept-source optical coherence tomography (SS-OCT) as a noninvasive detection modality for regions of retinal layer thinning that are potential indicators of retinal nonperfusion areas (NPAs) in patients with branch retinal vein occlusion (BRVO). Thirty-one eyes of 46 patients with BRVO showing a definite retinal NPA larger than 1 disc in diameter within the vascular arcades were included in this study. We calculated the overlapping correspondence ratio between presumed NPA, which appeared as a dark area in en face SS-OCT, and definite NPA in corresponding fluorescein angiography (FA) images. The correlation between brightness in en face SS-OCT ...

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    1-9 of 9
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    En face swept-source optical coherence tomography detecting thinning of inner retinal layers as an indicator of capillary nonperfusion Delineation of capillary dropout in the deep retinal capillary plexus using optical coherence tomography angiography in a patient with Purtscher’s retinopathy exhibiting normal fluorescein angiography findings: a case report Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy Extended field imaging using swept-source optical coherence tomography angiography in retinal vein occlusion Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis Vitreoretinal interface slab in optical coherence tomography-angiography for detecting diabetic retinal neovascularization Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography Deposits on retinal surface seen on optical coherence tomography in ocular amyloidosis Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography Health collaborations forged at CIIE begin to bear fruit Method for determining the topography of the cornea of an eye