1. Articles from Yanping Huang

    1-6 of 6
    1. Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography

      Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography

      Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method. Intra-ocular pressure was changed from 10 to 90 mmHg using two different loading rates to observe the pressure-apex displacement relationship and calculate the apparent ...

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    2. Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging

      Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging

      The recent development of optical coherence tomography in ophthalmology has shown great interests in using the system in 1 µm in contrast to 800 nm wavelength range due to the less reflection and absorption of retinal pigment epithelium and pigmented choroidal melanocytes in 1 µm wavelength. The clinical value of using 1 µm system has been demonstrated in choroid imaging, retinal and choroidal microcirculation, etc. By examining different aspects of the posterior eye, the specificity and sensitivity of diagnosis can be increased. On the other hand, higher speed can greatly reduce the measuring time and motion artifacts, which brings comfort ...

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    3. Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.

      Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.

      Optical coherence tomography (OCT)-based optical microangiography (OMAG) is a high-resolution, noninvasive imaging technique capable of providing three-dimensional in vivo blood flow visualization within microcirculatory tissue beds in the eye. Although the technique has demonstrated early clinical utility by imaging diseased eyes, its limited field of view (FOV) and the sensitivity to eye motion remain the two biggest challenges for the widespread clinical use of the technology. Here, we report the results of retinal OMAG imaging obtained from a Zeiss Cirrus 5000 spectral domain OCT system with motion tracking capability achieved by a line scan ophthalmoscope (LSO). The tracking LSO ...

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    4. Efficient method to suppress artifacts caused by tissue hyper-reflections in optical microangiography of retina in vivo

      Efficient method to suppress artifacts caused by tissue hyper-reflections in optical microangiography of retina in vivo

      Optical microangiography (OMAG) is an optical coherence tomography (OCT)-based imaging technique that is capable of achieving the angiographic imaging of biological tissues in vivo with a high imaging resolution and no need for dye injection. OMAG has a potential to become a clinical tool for the diagnosis and treatment monitoring of various retinopathies. In principle, OMAG extracts blood flow information based on a direct differentiation of complex or intensity OCT signals between repeated B-scans acquired at the same cross section, which is sensitive to blood cell movement. In practice, this method is prone to artifacts due to tissue hyper-reflection ...

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    5. Swept-Source OCT Angiography of Macular Telangiectasia Type 2

      Swept-Source OCT Angiography of Macular Telangiectasia Type 2

      BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm × 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS: OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in ...

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    6. Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms

      Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms

      To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-µm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 × 3–mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature ...

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    1-6 of 6
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  2. Topics in the News

    1. (5 articles) University of Washington
    2. (5 articles) Ruikang K. Wang
    3. (3 articles) Utkarsh Sharma
    4. (3 articles) Lin An
    5. (3 articles) Carl Zeiss Meditec
    6. (2 articles) University of Miami
    7. (2 articles) Mary K. Durbin
    8. (2 articles) Giovanni Gregori
    9. (2 articles) Philip J. Rosenfeld
    10. (2 articles) Harvard University
    11. (2 articles) Massachusetts General Hospital
    12. (2 articles) Carl Zeiss Meditec
    13. (1 articles) George Washington University
    14. (1 articles) Medical University of Vienna
    15. (1 articles) University of Hong Kong
    16. (1 articles) Guillermo J. Tearney
    17. (1 articles) Desmond C. Adler
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    Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms Swept-Source OCT Angiography of Macular Telangiectasia Type 2 Efficient method to suppress artifacts caused by tissue hyper-reflections in optical microangiography of retina in vivo Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking. Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront Detecting glaucoma based on spectral domain optical coherence tomography imaging of peripapillary retinal nerve fiber layer: a comparison study between hand-crafted features and deep learning model Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients Optical coherence tomography of retinal and choroidal layers in patients with familial hypercholesterolaemia treated with lipoprotein apheresis SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND INDOCYANINE GREEN ANGIOGRAPHY COMPARISONS REVISITED