All Articles from David Huang -Optical Coherence Tomography News

Articles from David Huang

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1. Systems and methods for retinal layer segmentation in OCT imaging and OCT angiography
  
  Explore uspto.gov Nov 13 2018 Ophthalmology , Patents
  
  Disclosed herein are methods and systems for segmenting, visualizing, and quantifying the layered structure of retina in optical coherence tomography datasets. The disclosed methods have particular application to OCT angiography data, where specific retina layers have distinct vascular structures and characteristics that can be altered in various pathological conditions of the eye.
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  Mentions: David Huang Oregon Health & Science University Yali Jia
2. Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography
  
  Explore OSA | OSA Publishing Nov 3 2018 Ophthalmology
  
  Visible light optical coherence tomography (vis-OCT) is an emerging label-free and high-resolution 3-dimensional imaging technique that can provide retinal oximetry, angiography, and flowmetry in one modality. In this paper, we studied the organization of the arterial and venous retinal circulation in rats using vis-OCT. Arterioles were found predominantly in the superficial vascular plexus whereas veins tended to drain capillaries from the deep capillary plexus. After that, we determined the oxygen metabolic rate supported by retinal microcirculation by combining retinal vessel oxygen saturation and blood flow measurements. The ability to visualize and monitor retinal circulation organization and oxygen metabolism by vis-OCT ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
3. Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report
  
  Explore LWW Online Oct 9 2018 Ophthalmology
  
  Rationale: Retinal artery occlusion (RAO) results in painless, catastrophic vision loss in a period of seconds. Optical coherence tomography angiography (OCTA) can image retinal microcirculation, which is helpful to evaluate treatment response during the follow-up period. Using a single case with central RAO, we report its retinal perfusion changes before and after treatment using OCTA. Patient concerns: A 36-year-old Chinese man came to our clinic with a sudden, painless loss of vision (hand motion) in his left eye. A vasodilator (nicotinic acid) was used as the primary treatment. OCTA imaging and a visual field examination were performed to assess the ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
4. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University
  
  Explore Optical Coherence Tomography News Sep 8 2018 Jobs & Studentships
  
  A postdoctoral research fellowship/research associate position is immediately available in the Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University. The fellowship will focus on interdisciplinary projects in the field of optical imaging and real-time image processing. Ph.D. in Optics, Biomedical Engineering, Electrical Engineering, Computer Science or a related field is required. Demonstrated excellence in one or more of the following areas is required: expertise in optical coherence Tomography, scanning laser ophthalmoscope and adaptive optics, optical/electrical system design, prototyping and simulation, data acquisition and system control/synchronization, and C++/GPU ...
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
5. Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography
  
  Explore OSA | OSA Publishing Aug 28 2018 Ophthalmology
  
  Advances in the retinal layer segmentation of structural optical coherence tomography (OCT) images have allowed the separation of capillary plexuses in OCT angiography (OCTA). With the increased scanning speeds of OCT devices and wider field images (≥10 mm on fast-axis), greater retinal curvature and anatomic variations have introduced new challenges. In this study, we developed a novel automated method to segment seven retinal layer boundaries and two retinal plexuses in wide-field OCTA images. The algorithm was initialized by a series of points forming a guidance point array that estimates the location of retinal layer boundaries. A guided bidirectional graph search ...
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  Mentions: David Huang Topcon Medical Systems Oregon Health & Science University
6. Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography
  
  Explore IOVS Journal Aug 28 2018 Ophthalmology
  
  Purpose : To evaluate if projection-resolved optical coherence tomographic angiography (PR-OCTA) reduces projection artifact with less attenuation of choroidal neovascularization (CNV) flow signal compared to conventional OCTA with slab subtraction. Methods : In this retrospective cross-sectional study, participants with subfoveal treatment-naïve CNV secondary to age-related macular degeneration underwent OCTA. Scans were exported for custom processing including manual segmentation as necessary, application of slab subtraction and PR-OCTA algorithm, and calculation of CNV vascular area and connectivity. CNV was classified as type 1, minimally type 2, or predominantly type 2 based on fluorescein angiography (FA) and OCT. Two masked retina specialists independently classified ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
7. Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases
  
  Explore OSA | OSA Publishing Jun 16 2018 Ophthalmology
  
  The objective quantification of photoreceptor loss in inherited retinal degenerations (IRD) is essential for measuring disease progression, and is now especially important with the growing number of clinical trials. Optical coherence tomography (OCT) is a non-invasive imaging technology widely used to recognize and quantify such anomalies. Here, we implement a versatile method based on a convolutional neural network to segment the regions of preserved photoreceptors in two different IRDs (choroideremia and retinitis pigmentosa) from OCT images. An excellent segmentation accuracy (~90%) was achieved for both IRDs. Due to the flexibility of this technique, it has potential to be extended to ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
8. Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes
  
  Explore The JAMA Network Jun 14 2018 Ophthalmology
  
  Importance Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants Cross-sectional study at a tertiary academic center comprising 1 eye each from healthy control individuals and patients with diabetes at different severity stages of retinopathy. Data were acquired and analyzed between January 2015 and ...
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  Mentions: National Institutes of Health Optovue David Huang
9. Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography
  
  Explore uspto.gov May 29 2018 Ophthalmology , Patents
  
  Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.
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  Mentions: David Huang Oregon Health & Science University Yali Jia
10. Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography
  
  Explore IOVS Journal May 5 2018 Ophthalmology
  
  Purpose : To describe an automated algorithm to quantify the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), and to compare its performance for diagnosis of diabetic retinopathy (DR) and association with best-corrected visual acuity (BCVA) to that of extrafoveal avascular area (EAA). Methods : We obtained 3 × 3-mm macular OCTA scans in diabetic patients with various levels of DR and healthy controls. An algorithm based on a generalized gradient vector flow (GGVF) snake model detected the FAZ, and metrics assessing FAZ size and irregularity were calculated. We compared the automated FAZ segmentation to manual delineation and tested the within-visit ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
11. Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT
  
  Explore OSA | OSA Publishing May 2 2018
  
  Phase-based optical coherence tomography (OCT), such as OCT angiography (OCTA) and Doppler OCT, is sensitive to the confounding phase shift introduced by subject bulk motion. Traditional bulk motion compensation methods are limited by their accuracy and computing cost-effectiveness. In this Letter, to the best of our knowledge, we present a novel bulk motion compensation method for phase-based functional OCT. Bulk motion associated phase shift can be directly derived by solving its equation using a standard deviation of phase-based OCTA and Doppler OCT flow signals. This method was evaluated on rodent retinal images acquired by a prototype visible light OCT and ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
12. Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
  
  Explore m4.healio.com Apr 28 2018 Ophthalmology
  
  Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may be used as noninvasive imaging modalities for IP and similar retinal vascular disorders in supine young children.
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
13. OCT in Diagnosis of Irregular Corneas
  
  Explore Home - ClinicalTrials.gov Apr 25 2018 Ophthalmology , Clinical Trials
  
  This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: Develop an OCT-based system to classify and evaluate corneal-shape irregularities. Develop OCT metrics for more sensitive detection of keratoconus progression. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
14. Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
  
  Explore Healio.com Apr 20 2018 Ophthalmology
  
  Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may be used as noninvasive imaging modalities for IP and similar retinal vascular disorders in supine young children.
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
15. Automated spectroscopic retinal oximetry with visible-light optical coherence tomography
  
  Explore OSA | OSA Publishing Apr 16 2018 Ophthalmology
  
  Accurate, quantitative assessment of retinal blood oxygen saturation ( sO 2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO 2 within the retinal arteries (A- sO 2 ) and veins (V- sO 2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was validated in vitro with flow phantoms and in vivo in rats by comparing the sO 2 results, respectively, to those obtained using a blood gas analyzer and pulse oximetry. We ...
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  Mentions: Optovue David Huang Oregon Health & Science University
16. Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography
  
  Explore uspto.gov Mar 20 2018 Ophthalmology , Patents
  
  A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.
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  Mentions: David Huang Oregon Health & Science University Ou Tan
17. Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography
  
  Explore TVST Journal Feb 13 2018 Ophthalmology
  
  Purpose : To devise a method to quantify nerve fibers over their arcuate courses over an extended peripapillary area using optical coherence tomography (OCT). Methods : Participants were imaged with 8 × 8-mm volumetric OCT scans centered at the optic disc. A new quantity, nerve fiber flux (NFF), represents the cross-sectional area transected perpendicular to the nerve fibers. The peripapillary area was divided into 64 tracks with equal flux. An iterative algorithm traced the trajectory of the tracks assuming that the relative distribution of the NFF was conserved with compensation for fiber connections to ganglion cells on the macular side. Average trajectory was ...
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  Mentions: David Huang Oregon Health & Science University Ou Tan
18. Post-Doctoral Fellowship on Ophthalmic Imaging and Lasers at Oregon Science & Health University
  
  Explore Optical Coherence Tomography News Jan 23 2018 Jobs & Studentships
  
  A postdoctoral research fellowship/research associate position is immediately available in the Center for Ophthalmic Optics and Lasers (COOL), Casey Eye Institute, Oregon Health & Science University. The fellowship will focus on the development and clinical applications of novel ophthalmic OCT/OCT angiography systems and laser therapeutic devices. Ph.D in Optics, Biomedical Engineering, Electrical Engineering or a related field is required. Demonstrated excellence in one or more of the following area is required: optical system set-up, image acquisition control software, optical design/simulation using Zemax software and C++/GPU programming for real-time processing. Broad experience in optics, signal processing, image ...
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
19. Post-Doctoral Fellowship on Image Processing (OCT and OCTA) at Oregon Health & Science University
  
  Explore Optical Coherence Tomography News Jan 23 2018 Jobs & Studentships
  
  A postdoctoral research fellowship is immediately available in the Center for Ophthalmic Optics and Lasers, Casey Eye Institute, Oregon Health & Science University. The researcher on this position will work alongside experts in clinical and engineering disciplines to develop image processing algorithms for artifact reduction, registration, segmentation, detection, analysis and modelling of OCT and OCT angiography data. PhD degree in Computer Science, Biomedical Engineering, Electrical Engineering, Physics, Optics or a related field is required. Experience on image processing, modelling algorithms or machine learning is required. Broad experiences with optical systems, signal processing, concepts particularly coherence, interferometry and Fourier transform are also ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
20. Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning
  
  Explore Wiley Online Library Jan 17 2018 Ophthalmology
  
  Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRD). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in sixteen eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected separately by a local active contour routine. The algorithm is implemented on en face images with minimum segmentation requirements, only needing delineation of the Bruch's membrane, thus evading the ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
21. Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma
  
  Explore ScienceDirect Jan 13 2018 Ophthalmology
  
  Purpose To report a case of age-related hypertrophy of the nonpigmented ciliary epithelium (ARH-NPCE) clinically resembling a ciliary body melanoma and report the optical coherence tomography angiography (OCTA) findings associated with this lesion. Observations A 51-year-old male was referred for evaluation of a deeply pigmented ciliary body mass with extension through the iris root. Iridocyclectomy was performed due to concern for ciliary body melanoma. Histopathologic analysis was instead consistent with ARH-NPCE, also known as Fuchs' adenoma. Prior to surgery, OCTA images revealed abnormal vasculature in the area of the lesion. Vessels in the peripheral iris approaching the lesion appeared more ...
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  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
22. Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy
  
  Explore American Journal of Ophthalmology Dec 7 2017 Ophthalmology
  
  Purpose To compare patient and Medicare savings from the use of optical coherence tomography (OCT) in guiding therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in developing OCT by the National Institutes of Health (NIH) and the National Science Foundation (NSF). Design Observational cohort study. Methods Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology codes on intravitreal injections (67028), retinal OCT imaging (92134), and anti–vascular endothelial growth factor (anti-VEGF) treatment–specific J-codes (J0178, J2778, J9035, J3490, and J3590). These claims were identified from the Medicare Provider Utilization and Payment Data ...
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  Mentions: Philip J. Rosenfeld National Institutes of Health David Huang
23. Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography
  
  Explore Wiley Online Library Dec 6 2017 Ophthalmology
  
  A polarization-multiplexed, dual-beam setup is proposed to expand the field of view for a swept source optical coherence tomography angiography (OCTA) system. This method used a Wollaston prism to split sample path light into two orthogonal-polarized beams. This allowed two beams to shine on the cornea at an angle separation of ~ 14 degrees, which led to a separation of ~ 4.2 mm on the retina. A 3-mm glass plate was inserted into one of the beam paths to set a constant path length difference between the two polarized beams so the interferogram from the two beams are coded at different ...
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  Mentions: David Huang Oregon Health & Science University Yali Jia
24. Imaging of Iris Lesions With High-Speed Optical Coherence Tomography
  
  Explore m4.healio.com Dec 3 2017 Ophthalmology
  
  n BACKGROUND AND OBJECTIVES:To image and measure iris tumors with optical coherence tomography (OCT). n PATIENTS AND METHODS:High-speed(2,000– 4,000 axial-scan/sec and 4–16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy. n RESULTS: OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion ...
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  Mentions: Joseph A. Izatt Andrew M. Rollins David Huang
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